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1. CD1d-dependent immune suppression mediated by regulatory B cells through modulations of iNKT cells

Author: K. Oleinika, E. C. Rosser, D. E. Matei, K. Nistala, A. Bosma, I. Drozdov, and C. Mauri
Subjects: Science
Abstract: Regulatory B cells (Breg) are known to suppress immune responses by secreting interleukin-10 (IL-10). Here the authors show that, alternatively, Bregs may also present lipid antigens on surface CD1d to induce IFN-γ production from invariant natural killer cells to ameliorate experimental arthritis via IL-10-independent pathways.
Published: 2018
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2. O005 Perturbations in gut microbial metabolites promotes a pro-inflammatory state increasing risk of acute rejection post renal transplantation

Author: F Chang, A Vaitkute, M Attrill, S Chong, H Mahdi, P Blair, A Salama, C Mauri, S Eaton, M Bajaj-Elliott, A Pesenacker, and R Motallebzadeh
Subjects: Surgery
Abstract: Introduction Emerging evidence suggests that the gastrointestinal microbiota-immune axis impacts on extra-intestinal health. We aim to identify the influence of microbial metabolites on recipient's immunity; testing the hypothesis that reduced availability of bacterial-derived metabolites associated with immunoregulation e.g., short chain fatty acids (SCFAs) and tryptophan-derivatives promote a pro-inflammatory state increasing risk of acute rejection (AR). Methods Ninety recipients and 21 live-donors were recruited with urine, stool and blood samples collected at baseline and up to 12-months after surgery. Flow cytometry was used to assess for circulating subpopulations of CD19+ B-cells and CD4+ T cells (cTFH - CD3+CD4+CD45RA-CXCR5+ and cTFR -CD3+CD4+CXCR5+FoxP3+). Faecal SCFAs and indole derivatives were identified by mass spectroscopy and high-performance liquid chromatography. Results Patients with AR had an almost 10-fold reduction of FoxP3+ cTFR cells after transplantation compared to baseline (p=0.03). There were lower frequencies of cTFR cells at 3-months when compared to matched recipients without AR (0.009%±0.014% vs 0.10%±0.12%; p=0.01). In AR, there was a trend for higher frequencies of plasmablasts, resting memory B-cells and TFH cells at baseline, with fewer transitional B-cells at 3-months. Despite tryptophan availability increasing after transplantation, patients with AR displayed reduced levels of SCFAs at 1-month. Conclusion Complex changes in microbial metabolites exist after transplantation that may influence the balance of cTFH vs cTFR cells. Despite increase in dietary tryptophan, recipients with AR may harbour gut microbes that are unable to metabolise tryptophan into immune-regulatory metabolites, which predisposes a pro-inflammatory immune state.
Published: 2023
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3. S12.2 Type I interferons and their autoantibodies in the context of systemic lupus erythematosus

Author: L Haljasmägi, H Bradford, M Menon, P Peterson, M Vanker, C Wincup, V Bondet, D Duffy, D Isenberg, K Kisand, and C Mauri
Published: 2022
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4. Design, construction and operation of the ProtoDUNE-SP Liquid Argon TPC

Author: Abud, A. Abed Abi, B. Acciarri, R. Acero, M. A. Adames, M. R. Adamov, G. Adams, D. Adinolfi, M. Aduszkiewicz, A. and Aguilar, J. Ahmad, Z. Ahmed, J. Ali-Mohammadzadeh, B. and Alion, T. Allison, K. Monsalve, S. Alonso Alrashed, M. and Alt, C. Alton, A. Amedo, P. Anderson, J. and Andreopoulos, C. Andreotti, M. Andrews, M. P. Andrianala, F. and Andringa, S. Anfimov, N. Ankowski, A. Antoniassi, M. and Antonova, M. Antoshkin, A. Antusch, S. Aranda-Fernandez, A. and Ariga, A. Arnold, L. O. Arroyave, M. A. Asaadi, J. and Asquith, L. Aurisano, A. Aushev, V Autiero, D. and Ayala-Torres, M. Azfar, F. Back, A. Back, H. Back, J. J. and Backhouse, C. Baesso, P. Bagaturia, I Bagby, L. and Balashov, N. Balasubramanian, S. Baldi, P. Baller, B. and Bambah, B. Barao, F. Barenboim, G. Barker, G. J. and Barkhouse, W. Barnes, C. Barr, G. Barranco Monarca, J. and Barros, A. Barros, N. Barrow, J. L. Basharina-Freshville, A. and Bashyal, A. Basque, V Belchior, E. Battat, J. B. R. and Battisti, F. Bay, F. Alba, J. L. Bazo Beacom, J. F. and Bechetoille, E. Behera, B. Bellantoni, L. Bellettini, G. and Bellini, V Beltramello, O. Belver, D. Benekos, N. and Montiel, C. Benitez Neves, F. Bento Berger, J. Berkman, S. and Bernardini, P. Berner, R. M. Berns, H. Bertolucci, S. and Betancourt, M. Betancur Rodriguez, A. Bevan, A. Bezerra, T. J. C. Bhattacharjee, M. Bhuller, S. Bhuyan, B. Biagi, S. Bian, J. Biassoni, M. Biery, K. Bilki, B. Bishai, M. Bitadze, A. Blake, A. Blaszczyk, F. D. M. Blazey, G. C. Blucher, E. Boissevain, J. Bolognesi, S. Bolton, T. and Bomben, L. Bonesini, M. Bongrand, M. Bonini, F. and Booth, A. Booth, C. Boran, F. Bordoni, S. Borkum, A. and Boschi, T. Bostan, N. Bour, P. Bourgeois, C. Boyd, S. B. and Boyden, D. Bracinik, J. Braga, D. Brailsford, D. and Branca, A. Brandt, A. Bremer, J. Brew, C. Brianne, E. and Brice, S. J. Brizzolari, C. Bromberg, C. Brooijmans, G. and Brooke, J. Bross, A. Brunetti, G. Brunetti, M. and Buchanan, N. Budd, H. Butorov, I Cagnoli, I Caiulo, D. and Calabrese, R. Calafiura, P. Calcutt, J. Calin, M. and Calvez, S. Calvo, E. Caminata, A. Campanelli, M. and Cankocak, K. Caratelli, D. Carini, G. Carlus, B. and Carneiro, M. F. Carniti, P. Terrazas, I. Caro Carranza, H. and Carroll, T. Casta, J. F. Castillo, A. Castromonte, C. and Catano-Mur, E. Cattadori, C. Cavalier, F. Cavanna, F. and Centro, S. Cerati, G. Cervelli, A. Cervera Villanueva, A. Chalifour, M. Chappell, A. Chardonnet, E. and Charitonidis, N. Chatterjee, A. Chattopadhyay, S. Chen, H. and Chen, K. Chen, M. Chen, Y. Chen, Z. Cheon, Y. and Cherdack, D. Chi, C. Childress, S. Chiriacescu, A. and Chisnall, G. Cho, K. Choate, S. Chokheli, D. Chong, P. S. Choubey, S. Christensen, A. Christian, D. and Christodoulou, G. Chukanov, A. Chung, M. Church, E. and Cicero, V Clarke, P. Coan, T. E. Cocco, A. G. Coelho, J. A. B. Conley, E. Conley, R. Conrad, J. M. Convery, M. and Copello, S. Corwin, L. Valentim, R. Cremaldi, L. and Cremonesi, L. Crespo-Anadon, I, J. Crisler, M. Cristaldo, E. and Cross, R. Cudd, A. Cuesta, C. Cui, Y. Cussans, D. and Dabrowski, M. Dalager, O. da Motta, H. Peres, L. Da Silva David, C. David, Q. Davies, G. S. Davini, S. and Dawson, J. De, K. De Almeida, R. M. Debbins, P. De Bonis, I Decowski, M. P. de Gouvea, A. De Holanda, P. C. and Astiz, I. L. De Icaza Deisting, A. De Jong, P. Delbart, A. and Delepine, D. Delgado, M. Dell'Acqua, A. De Lurgio, P. and de Mello Neto, J. R. T. DeMuth, D. M. Dennis, S. and Densham, C. Deptuch, G. W. De Roeck, A. De Romeri, V De Souza, G. Devi, R. Dharmapalan, R. Dias, M. Diaz, F. and Diaz, J. S. Di Domizio, S. Di Giulio, L. Ding, P. Di Noto, L. Distefano, C. Diurba, R. Diwan, M. Djurcic, Z. and Doering, D. Dolan, S. Dolek, F. Dolinski, M. J. and Domine, L. Douglas, D. Douillet, D. Drake, G. Drielsma, F. Duarte, L. Duchesneau, D. Duffy, K. Dunne, P. and Durkin, T. Duyang, H. Dvornikov, O. Dwyer, D. A. and Dyshkant, A. S. Eads, M. Earle, A. Edmunds, D. Eisch, J. and Emberger, L. Emery, S. Ereditato, A. Erjavec, T. and Escobar, C. O. Eurin, G. Evans, J. J. Ewart, E. Ezeribe, A. C. Fahey, K. Falcone, A. Fani, M. Farnese, C. and Farzan, Y. Fedoseev, D. Felix, J. Feng, Y. and Fernandez-Martinez, E. Fernandez Menendez, P. Fernandez Morales, M. Ferraro, F. Fields, L. Filip, P. Filthaut, F. and Fiorentini, A. Fiorini, M. Fitzpatrick, R. S. Flanagan, W. and Fleming, B. Flight, R. Forero, V, D. Fowler, J. Fox, W. Franc, J. Francis, K. Franco, D. Freeman, J. and Freestone, J. Fried, J. Friedland, A. Robayo, F. Fuentes and Fuess, S. Furic, I Furmanski, A. P. Gabrielli, A. Gago, A. Gallagher, H. Gallas, A. Gallego-Ros, A. Gallice, N. and Galymov, V Gamberini, E. Gamble, T. Ganacim, F. and Gandhi, R. Gandrajula, R. Gao, F. Gao, S. Garcia, A. C. B. Garcia-Gamez, D. Garcia-Peris, M. A. Gardiner, S. and Gastler, D. Gauvreau, J. Ge, G. Gelli, B. Gendotti, A. and Gent, S. Ghorbani-Moghaddam, Z. Giammaria, P. Giammaria, T. Gibin, D. Gil-Botella, I Gilligan, S. Girerd, C. and Giri, A. K. Gnani, D. Gogota, O. Gold, M. Gollapinni, S. and Gollwitzer, K. Gomes, R. A. Gomez Bermeo, V, L. Gomez Fajardo, L. S. Gonnella, F. Gonzalez-Cuevas, J. A. Gonzalez Diaz, D. Gonzalez-Lopez, M. Goodman, M. C. Goodwin, O. and Goswami, S. Gotti, C. Goudzovski, E. Grace, C. Graham, M. Gran, R. Granados, E. Granger, P. Grant, A. and Grant, C. Gratieri, D. Green, P. Greenler, L. Greer, J. and Grenard, J. Griffith, W. C. Groh, M. Grudzinski, J. and Grzelak, K. Gu, W. Guardincerri, E. Guarino, V Guarise, M. Guenette, R. Guerard, E. Guerzoni, M. Guglielmi, A. and Guo, B. Guthikonda, K. K. Gutierrez, R. Guzowski, P. and Guzzo, M. M. Gwon, S. Ha, C. Habig, A. Hadavand, H. and Haenni, R. Hahn, A. Haiston, J. Hamacher-Baumann, P. and Hamernik, T. Hamilton, P. Han, J. Harris, D. A. and Hartnell, J. Harton, J. Hasegawa, T. Hasnip, C. Hatcher, R. Hatfield, K. W. Hatzikoutelis, A. Hayes, C. and Hayrapetyan, K. Hays, J. Hazen, E. He, M. Heavey, A. and Heeger, K. M. Heise, J. Hennessy, K. Henry, S. and Morquecho, M. A. Hernandez Herner, K. Hertel, L. Hewes, J. and Higuera, A. Hill, T. Hillier, S. J. Himmel, A. and Hirsch, L. R. Ho, J. Hoff, J. Holin, A. Hoppe, E. and Horton-Smith, G. A. Hostert, M. Hourlier, A. Howard, B. and Howell, R. Hristova, I Hronek, M. S. Huang, J. Huang, J. and Hugon, J. Iles, G. Ilic, N. Iliescu, A. M. and Illingworth, R. Ingratta, G. Ioannisian, A. Isenhower, L. and Itay, R. Izmaylov, A. Jackson, C. M. Jain, V James, E. Jang, W. Jargowsky, B. Jediny, F. Jena, D. Jeong, Y. S. Jesus-Valls, C. Ji, X. Jiang, L. Jimenez, S. and Jipa, A. Johnson, R. Johnston, N. Jones, B. Jones, S. B. and Judah, M. Jung, C. K. Junk, T. Jwa, Y. Kabirnezhad, M. Kaboth, A. Kadenko, I Kalra, D. Kakorin, I and Kalitkina, A. Kamiya, F. Kaneshige, N. Karagiorgi, G. and Karaman, G. Karcher, A. Karolak, M. Karyotakis, Y. and Kasai, S. Kasetti, S. P. Kashur, L. Kazaryan, N. Kearns, E. Keener, P. Kelly, K. J. Kemp, E. Kemularia, O. and Ketchum, W. Kettell, S. H. Khabibullin, M. Khotjantsev, A. and Khvedelidze, A. Kim, D. King, B. Kirby, B. Kirby, M. and Klein, J. Koehler, K. Koerner, L. W. Kohn, S. and Koller, P. P. Kolupaeva, L. Korablev, D. Kordosky, M. and Kosc, T. Kose, U. Kostelecky, V. A. Kothekar, K. and Krennrich, F. Kreslo, I Kropp, W. Kudenko, Y. and Kudryavtsev, V. A. Kulagin, S. Kumar, J. Kumar, P. and Kunze, P. Kuruppu, C. Kus, V Kutter, T. Kvasnicka, J. and Kwak, D. Lambert, A. Land, B. J. Lande, K. Lane, C. E. Lang, K. Langford, T. Langstaff, M. Larkin, J. and Lasorak, P. Last, D. Lastoria, C. Laundrie, A. Laurenti, G. Lawrence, A. Lazanu, I LaZur, R. Lazzaroni, M. and Le, T. Leardini, S. Learned, J. LeBrun, P. LeCompte, T. and Lee, C. Lee, S. Y. Miotto, G. Lehmann Lehnert, R. de Oliveira, M. A. Leigui Leitner, M. Lepin, L. M. Li, L. and Li, S. W. Li, T. Li, Y. Liao, H. Lin, C. S. Lin, Q. and Lin, S. Ling, J. Lister, A. Littlejohn, B. R. Liu, J. Lockwitz, S. Loew, T. Lokajicek, M. Lomidze, I and Long, K. Loo, K. Lord, T. LoSecco, J. M. Louis, W. C. and Lu, X-G Luk, K. B. Luo, X. Luppi, E. Lurkin, N. and Lux, T. Luzio, V. P. MacFarlane, D. Machado, A. A. and Machado, P. Macias, C. T. Macier, J. R. Maddalena, A. and Madera, A. Madigan, P. Magill, S. Mahn, K. Maio, A. and Major, A. Maloney, J. A. Mandrioli, G. Mandujano, R. C. and Maneira, J. Manenti, L. Manly, S. Mann, A. Manolopoulos, K. Plata, M. Manrique Manyam, V. N. Manzanillas, L. and Marchan, M. Marchionni, A. Marciano, W. Marfatia, D. and Mariani, C. Maricic, J. Marie, R. Marinho, F. Marino, A. D. Marsden, D. Marshak, M. Marshall, C. M. Marshall, J. and Marteau, J. Martin-Albo, J. Martinez, N. Caicedo, D. A. Martinez Martynenko, S. Mascagna, V Mason, K. Mastbaum, A. Masud, M. Matichard, F. Matsuno, S. Matthews, J. and Mauger, C. Mauri, N. Mavrokoridis, K. Mawby, I Mazza, R. and Mazzacane, A. Mazzucato, E. McAskill, T. McCluskey, E. and McConkey, N. McFarland, K. S. McGrew, C. McNab, A. and Mefodiev, A. Mehta, P. Melas, P. Mena, O. Menary, S. and Mendez, H. Mendez, P. Menegolli, A. Meng, G. Messier, M. D. Metcalf, W. Mettler, T. Mewes, M. Meyer, H. Miao, T. Michna, G. Miedema, T. Mikola, V Milincic, R. and Miller, G. Miller, W. Mills, J. Milne, C. Mineev, O. and Miranda, O. G. Miryala, S. Mishra, C. S. Mishra, S. R. and Mislivec, A. Mladenov, D. Mocioiu, I Moffat, K. Moggi, N. Mohanta, R. Mohayai, T. A. Mokhov, N. Molina, J. and Bueno, L. Molina Montagna, E. Montanari, A. Montanari, C. and Montanari, D. Montano Zetina, L. M. Moon, J. Moon, S. H. and Mooney, M. Moor, A. F. Moreno, D. Morris, C. Mossey, C. Motuk, E. Moura, C. A. Mousseau, J. Mouster, G. and Mu, W. Mualem, L. Mueller, J. Muether, M. Mufson, S. and Muheim, F. Muir, A. Mulhearn, M. Munford, D. Muramatsu, H. Murphy, S. Musser, J. Nachtman, J. Nagu, S. and Nalbandyan, M. Nandakumar, R. Naples, D. Narita, S. and Nath, A. Navas-Nicolas, D. Navrer-Agasson, A. Nayak, N. and Nebot-Guinot, M. Negishi, K. Nelson, J. K. Nesbit, J. and Nessi, M. Newbold, D. Newcomer, M. Newhart, D. Newton, H. Nichol, R. Nicolas-Arnaldos, F. Niner, E. Nishimura, K. Norman, A. Norrick, A. Northrop, R. Novella, P. and Nowak, J. A. Oberling, M. Ochoa-Ricoux, J. P. Del Campo, A. Olivares Olivier, A. Olshevskiy, A. Onel, Y. Onishchuk, Y. Ott, J. Pagani, L. Pakvasa, S. Palacio, G. and Palamara, O. Palestini, S. Paley, J. M. Pallavicini, M. and Palomares, C. Palomino-Gallo, J. L. Vazquez, W. Panduro and Pantic, E. Paolone, V Papadimitriou, V Papaleo, R. and Papanestis, A. Paramesvaran, S. Parke, S. Parozzi, E. and Parsa, Z. Parvu, M. Pascoli, S. Pasqualini, L. and Pasternak, J. Pater, J. Patrick, C. Patrizii, L. and Patterson, R. B. Patton, S. J. Patzak, T. Paudel, A. and Paulos, B. Paulucci, L. Pavlovic, Z. Pawloski, G. Payne, D. Pec, V Peeters, S. J. M. Pennacchio, E. Penzo, A. and Peres, O. L. G. Perry, J. Pershey, D. Pessina, G. and Petrillo, G. Petta, C. Petti, R. Piastra, F. Pickering, L. Pietropaolo, F. Plunkett, R. Poling, R. Pons, X. and Poonthottathil, N. Poppi, F. Pordes, S. Porter, J. and Potekhin, M. Potenza, R. Potukuchi, B. V. K. S. Pozimski, J. and Pozzato, M. Prakash, S. Prakash, T. Prest, M. and Prince, S. Psihas, F. Pugnere, D. Qian, X. Bazetto, M. C. Queiroga Raaf, J. L. Radeka, V Rademacker, J. Radics, B. Rafique, A. Raguzin, E. Rai, M. Rajaoalisoa, M. and Rakhno, I Rakotonandrasana, A. Rakotondravohitra, L. and Ramachers, Y. A. Rameika, R. Ramirez Delgado, M. A. Ramson, B. Rappoldi, A. Raselli, G. Ratoff, P. Raut, S. and Razakamiandra, R. F. Rea, E. Real, J. S. Rebel, B. and Reggiani-Guzzo, M. Rehak, T. Reichenbacher, J. Reitzner, S. D. Sfar, H. Rejeb Renshaw, A. Rescia, S. Resnati, F. and Reynolds, A. Ribas, M. Riboldi, S. Riccio, C. Riccobene, G. Rice, L. C. J. Ricol, J. Rigamonti, A. Rigaut, Y. and Rivera, D. Robert, A. Rochester, L. Roda, M. Rodrigues, P. Alonso, M. J. Rodriguez Bonilla, E. Rodriguez Rondon, J. Rodriguez Villa, L. A. Romo Rosauro-Alcaraz, S. Rosenberg, M. Rosier, P. Roskovec, B. Rossella, M. Rossi, M. and Rout, J. Roy, P. Roy, S. Rubbia, A. Rubbia, C. and Rubio, F. C. Russell, B. Ruterbories, D. Rybnikov, A. and Saa-Hernandez, A. Saakyan, R. Sacerdoti, S. Safford, T. and Sahu, N. Sala, P. Samios, N. Samoylov, O. Sanchez, M. C. and Sandberg, V Sanders, D. A. Sankey, D. Santana, S. and Santos-Maldonado, M. Saoulidou, N. Sapienza, P. Sarasty, C. and Sarcevic, I Savage, G. Savinov, V Scaramelli, A. and Scarff, A. Scarpelli, A. Schaffer, T. Schellman, H. and Schifano, S. Schlabach, P. Schmitz, D. Scholberg, K. and Schukraft, A. Segreto, E. Selyunin, A. Senise, C. R. and Sensenig, J. Seoane, M. Seong, I Sergi, A. Sgalaberna, D. Shaevitz, M. H. Shafaq, S. Shamma, M. Sharankova, R. and Sharma, H. R. Sharma, R. Kumar, R. Shaw, T. and Shepherd-Themistocleous, C. Sheshukov, A. Shin, S. and Shoemaker, I Shooltz, D. Shrock, R. Siegel, H. Simard, L. Simon, F. Simos, N. Sinclair, J. Sinev, G. Singh, J. Singh, J. Singh, L. Singh, V Sipos, R. Sippach, F. W. Sirri, G. Sitraka, A. Siyeon, K. Skarpaas, K. and Smith, A. Smith, E. Smith, P. Smolik, J. Smy, M. and Snider, E. L. Snopok, P. Snowden-Ifft, D. Nunes, M. Soares and Sobel, H. Soderberg, M. Sokolov, S. Solano Salinas, C. J. Soldner-Rembold, S. Soleti, S. R. Solomey, N. and Solovov, V Sondheim, W. E. Sorel, M. Sotnikov, A. and Soto-Oton, J. Sousa, A. Soustruznik, K. Spagliardi, F. and Spanu, M. Spitz, J. Spooner, N. J. C. Spurgeon, K. and Staley, R. Stancari, M. Stanco, L. Stanley, R. Stein, R. and Steiner, H. M. Lisboa, A. F. Steklain Stewart, J. and Stillwell, B. Stock, J. Stocker, F. Stokes, T. Strait, M. Strauss, T. Striganov, S. Stuart, A. Suarez, J. G. and Sullivan, H. Summers, D. Surdo, A. Susic, V Suter, L. Sutera, C. M. Svoboda, R. Szczerbinska, B. Szelc, A. M. Tanaka, H. A. Oregui, B. Tapia Tapper, A. Tariq, S. and Tatar, E. Tayloe, R. Teklu, A. M. Tenti, M. Terao, K. Ternes, C. A. Terranova, F. Testera, G. Thakore, T. and Thea, A. Thompson, J. L. Thorn, C. Timm, S. C. and Tishchenko, V Todd, J. Tomassetti, L. Tonazzo, A. and Torbunov, D. Torti, M. Tortola, M. Tortorici, F. Tosi, N. Totani, D. Toups, M. Touramanis, C. Travaglini, R. and Trevor, J. Trilov, S. Trzaska, W. H. Tsai, Y. Tsai, Y-T Tsamalaidze, Z. Tsang, V, K. Tsverava, N. Tufanli, S. Tull, C. Tyley, E. Tzanov, M. Uboldi, L. Uchida, M. A. Urheim, J. Usher, T. Uzunyan, S. Vagins, M. R. and Vahle, P. Valdiviesso, G. A. Valencia, E. Pia, V and Vallari, Z. Vallazza, E. Valle, J. W. F. Vallecorsa, S. and Van Berg, R. Van de Water, R. G. Varanini, F. Vargas, D. and Varner, G. Vasel, J. Vasina, S. Vasseur, G. Vaughan, N. and Vaziri, K. Ventura, S. Verdugo, A. Vergani, S. and Vermeulen, M. A. Verzocchi, M. Vicenzi, M. de Souza, H. Vieira Vignoli, C. Vilela, C. Viren, B. Vrba, T. and Wachala, T. Waldron, V, A. Wallbank, M. Wallis, C. Wang, H. Wang, J. Wang, L. Wang, M. H. L. S. Wang, Y. and Wang, Y. Warburton, K. Warner, D. Wascko, M. O. Waters, D. Watson, A. Weatherly, P. Weber, A. Weber, M. Wei, H. Weinstein, A. Wenman, D. Wetstein, M. White, A. and Whitehead, L. H. Whittington, D. Wilking, M. J. Wilkinson, C. Williams, Z. Wilson, F. Wilson, R. J. Wisniewski, W. and Wolcott, J. Wongjirad, T. Wood, A. Wood, K. and Worcester, E. Worcester, M. Wret, C. Wu, W. Wu, W. and Xiao, Y. Xie, F. Yandel, E. Yang, G. Yang, K. Yang, S. Yang, T. Yankelevich, A. Yershov, N. Yonehara, K. and Young, T. Yu, B. Yu, H. Yu, H. Yu, J. Yuan, W. and Zaki, R. Zalesak, J. Zambelli, L. Zamorano, B. Zani, A. and Zazueta, L. Zeller, G. P. Zennamo, J. Zeug, K. and Zhang, C. Zhao, M. Zhivun, E. Zhu, G. Zilberman, P. and Zimmerman, E. D. Zito, M. Zucchelli, S. Zuklin, J. and Zutshi, V Zwaska, R. DUNE Collaboration
Abstract: The ProtoDUNE-SP detector is a single-phase liquid argon time projection chamber (LArTPC) that was constructed and operated in the CERN North Area at the end of the H4 beamline. This detector is a prototype for the first far detector module of the Deep Underground Neutrino Experiment (DUNE), which will be constructed at the Sandford Underground Research Facility (SURF) in Lead, South Dakota, U.S.A. The ProtoDUNE-SP detector incorporates full-size components as designed for DUNE and has an active volume of 7 x 6 x 7.2 m3. The H4 beam delivers incident particles with well-measured momenta and high-purity particle identification. ProtoDUNE-SP's successful operation between 2018 and 2020 demonstrates the effectiveness of the single-phase far detector design. This paper describes the design, construction, assembly and operation of the detector components.
Published: 2022

5. Les anticorps anti-biomédicament sont négativement associés à la réponse au traitement par anti-TNF monoclonaux et anti-IL-6 récepteur dans la polyarthrite rhumatoïde : les résultats de l'étude ABIRISK

Author: S. Bitoun, S. Hassler, N. Szely, A. Gleizes, S. Hacein Bey, C. Richez, M. Soubrier, J. Avouac, O. Brocq, J. Sellam, N. De Vries, T.W. Huizinga, E. Jury, J. Manson, C. Mauri, A. Mattuci, P. Bröet, X. Mariette, and Hässler, Signe
Subjects: [SDV.MHEP.RSOA] Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Rheumatology, [SDV.IMM] Life Sciences [q-bio]/Immunology, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie
Published: 2022

6. 581 Spontaneous, Intrinsic Aging in Organ-Cultured Human Skin as Novel Ex Vivo Assay to Test Candidate Anti-Aging Actives

Author: T. Bíró, M. van Lessen, A. Mardaryev, D. Broadley, C. Mauri, M. Bertolini, J. Edelkamp, and R. Paus
Subjects: Cell Biology, Dermatology, Molecular Biology, Biochemistry
Published: 2022
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7. Risk factors of pelvic pressure ulcer recurrence after primary skin flap surgery in people with spinal cord injury

Author: C. Mauri, Nicolas Frasson, A. Gelis, C. Herlin, Arnaud Dupeyron, B. Amara, C. Verollet, H. Rouays, Jacques Morel, J.-P. Daures, C. Jourdan, Isabelle Almeras, Service de Médecine Physique et Réadaptation [CHU de Grenoble] (MPR), Centre Hospitalier Universitaire [Grenoble] (CHU), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Aide à la Décision pour une Médecine Personnalisé - Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - EA 2415 (AIDMP), Université Montpellier 1 (UM1)-Université de Montpellier (UM), Hôpital Lapeyronie [Montpellier] (CHU), Centre Mutualiste de Réeducation Neurologique Propara (PROPARA), Languedoc Mutualité, Euromov (EuroMov), Université de Montpellier (UM), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), and Institut Universitaire de Recherche Clinique
Subjects: Adult, Male, 030506 rehabilitation, medicine.medical_specialty, Multivariate analysis, medicine.medical_treatment, Spinal cord injury, Surgical Flaps, Pelvis, Young Adult, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, Recurrence, Risk Factors, medicine, Humans, Orthopedics and Sports Medicine, Risk factor, Spinal Cord Injuries, Aged, Proportional Hazards Models, Retrospective Studies, Aged, 80 and over, Pressure Ulcer, business.industry, Flap surgery, Rehabilitation, Hazard ratio, Colostomy, Retrospective cohort study, Skin Transplantation, Middle Aged, medicine.disease, Confidence interval, 3. Good health, Surgery, Treatment Outcome, Regression Analysis, Female, Observational study, 0305 other medical science, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, 030217 neurology & neurosurgery
Abstract: Background Flap surgery for deep pelvic pressure ulcers (PPUs) has been found effective, but the recurrence rate remains high and few risk factors have been identified. Objective We evaluated risk factors for PU recurrence after primary flap surgery in people with spinal cord injury (SCI). Patients and methods This observational retrospective study based on medical charts included all individuals with SCI who underwent primary flap surgery for a PPU in the Herault department in France between 2006 and 2014. Overall, 100 biomedical, psychological, socioeconomic and care management factors were studied. The primary outcome was PPU recurrence (surgical site and/or other pelvic site). The secondary outcome was recurrence at the surgical site. Cox proportional hazards regression was used to determine associated factors, estimating hazard ratios (HRs) and 95% confidence intervals (CIs). Results We included 85 patients. Half had a PPU recurrence, and in one-third, the recurrence was at the surgical site. On multivariate analysis, global PPU recurrence was associated with colostomy (HR = 2.79) and living with a partner (HR = 2.29). Non-traumatic SCI and sacral wound were associated with PPU recurrence (HR = 3.39, HR = 0.48) and recurrence at the surgical site (HR = 3.3, HR = 0.3). Conclusion Risk factors of PPU recurrence are based on both biomedical and social models. After primary flap surgery, the risk of recurrence justifies regular follow-up and strict monitoring.
Published: 2019
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8. 842 Novel human skin organ culture models for the identification and characterization of anti-aging actives ex vivo

Author: M. van Lessen, A. Mardaryev, C. Mauri, D. Broadley, M. Bertolini, J. Edelkamp, R. Paus, and T. Bíró
Subjects: Cell Biology, Dermatology, Molecular Biology, Biochemistry
Published: 2022
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9. Consensus Guidelines for the Definition of Time-to-Event End Points in Image-guided Tumor Ablation: Results of the SIO and DATECAN Initiative

Author: Puijk, Robbert S. Ahmed, Muneeb Adam, Andreas Arai, Yasuaki Arellano, Ronald de Baère, Thierry Bale, Reto Bellera, Carine Binkert, Christoph A. Brace, Christopher L. Breen, David J. Brountzos, Elias Callstrom, Matthew R. Carrafiello, Gianpaolo Chapiro, Julius de Cobelli, Francesco Coupé, Veerle M. H. Crocetti, Laura Denys, Alban Dupuy, Damian E. Erinjeri, Joseph P. Filippiadis, Dimitris Gangi, Afshin Gervais, Debra A. Gillams, Alice R. Greene, Tissy Guiu, Boris Helmberger, Thomas Iezzi, Roberto Kang, Tae Wook Kelekis, Alexis Kim, Hyun S. Kröncke, Thomas Kwan, Sharon Lee, Min Woo Lee, Fred T. Lee, Edward W. Jr Liang, Ping Lissenberg-Witte, Birgit I. Lu, David S. Madoff, David C. Mauri, Giovanni Meloni, Maria Franca Morgan, Robert Nadolski, Gregory Narayanan, Govindarajan Newton, Isabel Nikolic, Boris Orsi, Franco Pereira, Philippe L. Pua, Uei Rhim, Hyunchul Ricke, Jens Rilling, William Salem, Riad Scheffer, Hester J. Sofocleous, Constantinos T. Solbiati, Luigi A. Solomon, Stephen B. Soulen, Michael C. Sze, Daniel Uberoi, Raman Vogl, Thomas J. Wang, David S. Wood, Bradford J. Goldberg, S. Nahum Meijerink, Martijn R.
Abstract: There is currently no consensus regarding preferred clinical outcome measures following image-guided tumor ablation or clear definitions of oncologic end points. This consensus document proposes standardized definitions for a broad range of oncologic outcome measures with recommendations on how to uniformly document, analyze, and report outcomes. The initiative was coordinated by the Society of Interventional Oncology in collaboration with the Definition for the Assessment of Time-to-Event End Points in Cancer Trials, or DATECAN, group. According to predefined criteria, based on experience with clinical trials, an international panel of 62 experts convened. Recommendations were developed using the validated three-step modified Delphi consensus method. Consensus was reached on when to assess outcomes per patient, per session, or per tumor; on starting and ending time and survival time definitions; and on time-to-event end points. Although no consensus was reached on the preferred classification system to report complications, quality of life, and health economics issues, the panel did agree on using the most recent version of a validated patient-reported outcome questionnaire. This article provides a framework of key opinion leader recommendations with the intent to facilitate a clear interpretation of results and standardize worldwide communication. Widespread adoption will improve reproducibility, allow for accurate comparisons, and avoid misinterpretations in the field of interventional oncology research. Published under a CC BY 4.0 license. Online supplemental material is available for this article. See also the editorial by Liddell in this issue.
Published: 2021

10. Deep underground neutrino experiment (DUNE) near detector conceptual design report

Author: Abud, A.A. Abi, B. Acciarri, R. Acero, M.A. Adamov, G. Adams, D. Adinolfi, M. Aduszkiewicz, A. Ahmad, Z. Ahmed, J. Alion, T. Monsalve, S.A. Alrashed, M. Alt, C. Alton, A. Amedo, P. Anderson, J. Andreopoulos, C. Andrews, M.P. Andrianala, F. Andringa, S. Anfimov, N. Ankowski, A. Antonova, M. Antusch, S. Aranda-Fernandez, A. Ariga, A. Arnold, L.O. Arroyave, M.A. Asaadi, J. Aurisano, A. Aushev, V. Autiero, D. Ayala-Torres, M. Azfar, F. Back, A. Back, H. Back, J.J. Backhouse, C. Baesso, P. Bagaturia, I. Bagby, L. Balasubramanian, S. Baldi, P. Baller, B. Bambah, B. Barao, F. Barenboim, G. Barker, G.J. Barkhouse, W. Barnes, C. Barr, G. Monarca, J.B. Barros, N. Barrow, J.L. Basharina-Freshville, A. Bashyal, A. Basque, V. Belchior, E. Battat, J.B.R. Battisti, F. Bay, F. Alba, J.L.B. Beacom, J.F. Bechetoille, E. Behera, B. Bellantoni, L. Bellettini, G. Bellini, V. Beltramello, O. Belver, D. Benekos, N. Neves, F.B. Berkman, S. Bernardini, P. Berner, R.M. Berns, H. Bertolucci, S. Betancourt, M. Rodríguez, A.B. Bhattacharjee, M. Bhuller, S. Bhuyan, B. Biagi, S. Bian, J. Biassoni, M. Biery, K. Bilki, B. Bishai, M. Bitadze, A. Blake, A. Blaszczyk, F.D.M. Blazey, G.C. Blucher, E. Boissevain, J. Bolognesi, S. Bolton, T. Bomben, L. Bonesini, M. Bongrand, M. Bonini, F. Booth, A. Booth, C. Bordoni, S. Borkum, A. Boschi, T. Bostan, N. Bour, P. Bourgeois, C. Boyd, S.B. Boyden, D. Bracinik, J. Braga, D. Brailsford, D. Brandt, A. Bremer, J. Brew, C. Brianne, E. Brice, S.J. Brizzolari, C. Bromberg, C. Brooijmans, G. Brooke, J. Bross, A. Brunetti, G. Brunetti, M. Buchanan, N. Budd, H. Cagnoli, I. Caiulo, D. Calafiura, P. Calcutt, J. Calin, M. Calvez, S. Calvo, E. Caminata, A. Campanelli, M. Cankocak, K. Caratelli, D. Carini, G. Carlus, B. Carniti, P. Terrazas, I.C. Carranza, H. Carroll, T. Castaño Forero, J.F. Castillo, A. Castromonte, C. Catano-Mur, E. Cattadori, C. Cavalier, F. Cavanna, F. Centro, S. Cerati, G. Cervelli, A. Villanueva, A.C. Chalifour, M. Chappell, A. Chardonnet, E. Charitonidis, N. Chatterjee, A. Chattopadhyay, S. Chen, H. Chen, M. Chen, Y. Chen, Z. Cherdack, D. Chi, C. Childress, S. Chiriacescu, A. Chisnall, G. Cho, K. Choate, S. Chokheli, D. Choubey, S. Christensen, A. Christian, D. Christodoulou, G. Chukanov, A. Church, E. Cicero, V. Clarke, P. Coan, T.E. Cocco, A.G. Coelho, J.A.B. Conley, E. Conley, R. Conrad, J.M. Convery, M. Copello, S. Corwin, L. Cremaldi, L. Cremonesi, L. Crespo-Anadón, J.I. Cristaldo, E. Cross, R. Cudd, A. Cuesta, C. Cui, Y. Cussans, D. Dabrowski, M. Dalager, O. Da Motta, H. Da Silva Peres, L. David, C. David, Q. Davies, G.S. Davini, S. Dawson, J. De, K. De Almeida, R.M. Debbins, P. De Bonis, I. Decowski, M.P. De Gouvêa, A. De Holanda, P.C. De Icaza Astiz, I.L. Deisting, A. De Jong, P. Delbart, A. Delepine, D. Delgado, M. Dell’Acqua, A. De Lurgio, P. De Mello Neto, J.R.T. De Muth, D.M. Dennis, S. Densham, C. Deptuch, G.W. De Roeck, A. De Romeri, V. De Souza, G. Dharmapalan, R. Diaz, F. Díaz, J.S. Di Domizio, S. Di Giulio, L. Ding, P. Di Noto, L. Distefano, C. Diurba, R. Diwan, M. Djurcic, Z. Dokania, N. Dolan, S. Dolinski, M.J. Domine, L. Douglas, D. Douillet, D. Drake, G. Drielsma, F. Duchesneau, D. Duffy, K. Dunne, P. Durkin, T. Duyang, H. Dvornikov, O. Dwyer, D.A. Dyshkant, A.S. Eads, M. Earle, A. Edmunds, D. Eisch, J. Emberger, L. Emery, S. Ereditato, A. Escobar, C.O. Eurin, G. Evans, J.J. Ewart, E. Ezeribe, A.C. Fahey, K. Falcone, A. Farnese, C. Farzan, Y. Felix, J. Carneiro Da Silva, M.F. Fernandez-Martinez, E. Fernandez Menendez, P. Ferraro, F. Fields, L. Filthaut, F. Fiorentini, A. Fitzpatrick, R.S. Flanagan, W. Fleming, B. Flight, R. Forero, D.V. Fowler, J. Fox, W. Franc, J. Francis, K. Franco, D. Freeman, J. Freestone, J. Fried, J. Friedland, A. Fuess, S. Furic, I. Furmanski, A.P. Gabrielli, A. Gago, A. Gallagher, H. Gallas, A. Gallego-Ros, A. Gallice, N. Galymov, V. Gamberini, E. Gamble, T. Gandhi, R. Gandrajula, R. Gao, F. Gao, S. Garcia-Gamez, D. García-Peris, M.Á. Gardiner, S. Gastler, D. Ge, G. Gelli, B. Gendotti, A. Gent, S. Ghorbani-Moghaddam, Z. Gibin, D. Gil-Botella, I. Gilligan, S. Girerd, C. Giri, A.K. Gnani, D. Gogota, O. Gold, M. Gollapinni, S. Gollwitzer, K. Gomes, R.A. Gomez Bermeo, L.V. Gomez Fajardo, L.S. Gonnella, F. Gonzalez-Cuevas, J.A. Gonzalez-Diaz, D. Gonzalez-Lopez, M. Goodman, M.C. Goodwin, O. Goswami, S. Gotti, C. Goudzovski, E. Grace, C. Graham, M. Gran, R. Granados, E. Granger, P. Grant, A. Grant, C. Gratieri, D. Green, P. Greenler, L. Greer, J. Griffith, W.C. Groh, M. Grudzinski, J. Grzelak, K. Gu, W. Guarino, V. Guenette, R. Guerard, E. Guerzoni, M. Guglielmi, A. Guo, B. Guthikonda, K.K. Gutierrez, R. Guzowski, P. Guzzo, M.M. Gwon, S. Habig, A. Hadavand, H. Haenni, R. Hahn, A. Haiston, J. Hamacher-Baumann, P. Hamernik, T. Hamilton, P. Han, J. Harris, D.A. Hartnell, J. Harton, J. Hasegawa, T. Hasnip, C. Hatcher, R. Hatfield, K.W. Hatzikoutelis, A. Hayes, C. Hazen, E. Heavey, A. Heeger, K.M. Heise, J. Hennessy, K. Henry, S. Hernandez Morquecho, M.A. Herner, K. Hertel, L. Hewes, J. Higuera, A. Hill, T. Hillier, S.J. Himmel, A. Hoff, J. Hohl, C. Holin, A. Hoppe, E. Horton-Smith, G.A. Hostert, M. Hourlier, A. Howard, B. Howell, R. Huang, J. Huang, J. Hugon, J. Iles, G. Ilic, N. Iliescu, A.M. Illingworth, R. Ingratta, G. Ioannisian, A. Isenhower, L. Itay, R. Izmaylov, A. Jackson, S. Jain, V. James, E. Jargowsky, B. Jediny, F. Jena, D. Jeong, Y.S. Jesús-Valls, C. Ji, X. Jiang, L. Jiménez, S. Jipa, A. Johnson, R. Johnston, N. Jones, B. Jones, S.B. Judah, M. Jung, C.K. Junk, T. Jwa, Y. Kabirnezhad, M. Kaboth, A. Kadenko, I. Kakorin, I. Kamiya, F. Kaneshige, N. Karagiorgi, G. Karaman, G. Karcher, A. Karolak, M. Karyotakis, Y. Kasai, S. Kasetti, S.P. Kashur, L. Kazaryan, N. Kearns, E. Keener, P. Kelly, K.J. Kemp, E. Kemularia, O. Ketchum, W. Kettell, S.H. Khabibullin, M. Khotjantsev, A. Khvedelidze, A. Kim, D. King, B. Kirby, B. Kirby, M. Klein, J. Koehler, K. Koerner, L.W. Kohn, S. Koller, P.P. Kolupaeva, L. Kordosky, M. Kosc, T. Kose, U. Kostelecký, V.A. Kothekar, K. Krennrich, F. Kreslo, I. Kudenko, Y. Kudryavtsev, V.A. Kulagin, S. Kumar, J. Kumar, P. Kumar, R. Kunze, P. Kurita, N. Kuruppu, C. Kus, V. Kutter, T. Lambert, A. Land, B. Lande, K. Lane, C.E. Lang, K. Langford, T. Larkin, J. Lasorak, P. Last, D. Lastoria, C. Laundrie, A. Laurenti, G. Lawrence, A. Lazanu, I. Lazur, R. Le, T. Leardini, S. Learned, J. Lebrun, P. Lecompte, T. Lehmann Miotto, G. Lehnert, R. Leigui De Oliveira, M.A. Leitner, M. Li, L. Li, S.W. Li, T. Li, Y. Liao, H. Lin, C.S. Lin, Q. Lin, S. Lister, A. Littlejohn, B.R. Liu, J. Lockwitz, S. Loew, T. Lokajicek, M. Lomidze, I. Long, K. Loo, K. Lorca, D. Lord, T. Losecco, J.M. Louis, W.C. Lu, X.-G. Luk, K.B. Luo, X. Lurkin, N. Lux, T. Luzio, V.P. Macfarlane, D. Machado, A.A. Machado, P. Macias, C.T. Macier, J.R. Maddalena, A. Madera, A. Madigan, P. Magill, S. Mahn, K. Maio, A. Major, A. Maloney, J.A. Mandrioli, G. Mandujano, R.C. Maneira, J. Manenti, L. Manly, S. Mann, A. Manolopoulos, K. Manrique Plata, M. Manyam, V.N. Manzanillas, L. Marchan, M. Marchionni, A. Marciano, W. Marfatia, D. Mariani, C. Maricic, J. Marie, R. Marinho, F. Marino, A.D. Marsden, D. Marshak, M. Marshall, C.M. Marshall, J. Marteau, J. Martin-Albo, J. Martinez, N. Martinez Caicedo, D.A. Martynenko, S. Mason, K. Mastbaum, A. Masud, M. Matsuno, S. Matthews, J. Mauger, C. Mauri, N. Mavrokoridis, K. Mawby, I. Mazza, R. Mazzacane, A. Mazzucato, E. McAskill, T. McCluskey, E. McConkey, N. McFarland, K.S. McGrew, C. McNab, A. Mefodiev, A. Mehta, P. Melas, P. Mena, O. Menary, S. Mendez, H. Méndez, D.P. Menegolli, A. Meng, G. Messier, M.D. Metcalf, W. Mettler, T. Mewes, M. Meyer, H. Miao, T. Michna, G. Miedema, T. Migenda, J. Mikola, V. Milincic, R. Miller, W. Mills, J. Milne, C. Mineev, O. Miranda, O.G. Miryala, S. Mishra, C.S. Mishra, S.R. Mislivec, A. Mladenov, D. Mocioiu, I. Moffat, K. Moggi, N. Mohanta, R. Mohayai, T.A. Mokhov, N. Molina, J. Molina Bueno, L. Montanari, A. Montanari, C. Montanari, D. Montagna, E. Montano Zetina, L.M. Moon, J. Mooney, M. Moor, A.F. Moreno, D. Morris, C. Mossey, C. Motuk, E. Moura, C.A. Mousseau, J. Mu, W. Mualem, L. Mueller, J. Muether, M. Mufson, S. Muheim, F. Muir, A. Mulhearn, M. Munford, D. Muramatsu, H. Murphy, S. Musser, J. Nachtman, J. Nagu, S. Nalbandyan, M. Nandakumar, R. Naples, D. Narita, S. Navas-Nicolás, D. Navrer-Agasson, A. Nayak, N. Nebot-Guinot, M. Negishi, K. Nelson, J.K. Nesbit, J. Nessi, M. Newbold, D. Newcomer, M. Newhart, D. Newton, H. Niccolo, M. Nichol, R. Nicolas-Arnaldos, F. Nicoletta, M. Niner, E. Nishimura, K. Norman, A. Norrick, A. Northrop, R. Novella, P. Nowak, J.A. Oberling, M. Ochoa-Ricoux, J.P. Olivares Del Campo, A. Olivier, A. Olshevskiy, A. Onel, Y. Onishchuk, Y. Ott, J. Pagani, L. Pakvasa, S. Palacio, G. Palamara, O. Palestini, S. Paley, J.M. Pallavicini, M. Palomares, C. Palomino-Gallo, J.L. Pantic, E. Paolone, V. Papadimitriou, V. Papaleo, R. Papanestis, A. Paramesvaran, S. Parke, S. Parsa, Z. Parvu, M. Pascoli, S. Pasqualini, L. Pasternak, J. Pater, J. Patrick, C. Patrizii, L. Patterson, R.B. Patton, S.J. Patzak, T. Paudel, A. Paulos, B. Paulucci, L. Pavlovic, Z. Pawloski, G. Payne, D. Pec, V. Peeters, S.J.M. Pennacchio, E. Penzo, A. Peres, O.L.G. Perry, J. Pershey, D. Pessina, G. Petrillo, G. Petta, C. Petti, R. Piastra, F. Pickering, L. Pietropaolo, F. Plunkett, R. Poling, R. Pons, X. Poonthottathil, N. Poppi, F. Pordes, S. Porter, J. Potekhin, M. Potenza, R. Potukuchi, B.V.K.S. Pozimski, J. Pozzato, M. Prakash, S. Prakash, T. Prince, S. Pugnere, D. Qian, X. Queiroga Bazetto, M.C. Raaf, J.L. Radeka, V. Rademacker, J. Radics, B. Rafique, A. Raguzin, E. Rai, M. Rajaoalisoa, M. Rakhno, I. Rakotonandrasana, A. Rakotondravohitra, L. Ramachers, Y.A. Rameika, R. Ramirez Delgado, M.A. Ramson, B. Rappoldi, A. Raselli, G. Ratoff, P. Raut, S. Razakamiandra, R.F. Real, J.S. Rebel, B. Reggiani-Guzzo, M. Rehak, T. Reichenbacher, J. Reitzner, S.D. Rejeb Sfar, H. Renshaw, A. Rescia, S. Resnati, F. Reynolds, A. Riccio, C. Riccobene, G. Rice, L.C.J. Ricol, J. Rigamonti, A. Rigaut, Y. Rivera, D. Rochester, L. Roda, M. Rodrigues, P. Rodriguez Alonso, M.J. Rodriguez Bonilla, E. Rodriguez Rondon, J. Rosauro-Alcaraz, S. Rosenberg, M. Rosier, P. Roskovec, B. Rossella, M. Rout, J. Roy, P. Roy, S. Rubbia, A. Rubbia, C. Rubio, F.C. Russell, B. Ruterbories, D. Saakyan, R. Sacerdoti, S. Safford, T. Sahay, R. Sahu, N. Sala, P. Samios, N. Samoylov, O. Sanchez, M.C. Sanders, D.A. Sankey, D. Santana, S. Santos-Maldonado, M. Saoulidou, N. Sapienza, P. Sarasty, C. Sarcevic, I. Savage, G. Savinov, V. Scaramelli, A. Scarff, A. Scarpelli, A. Schaffer, T. Schellman, H. Schlabach, P. Schmitz, D. Scholberg, K. Schukraft, A. Segreto, E. Sensenig, J. Seong, I. Sergi, A. Sgalaberna, D. Shaevitz, M.H. Shafaq, S. Shamma, M. Sharankova, R. Sharma, H.R. Sharma, R. Shaw, T. Shepherd-Themistocleous, C. Shin, S. Shooltz, D. Shrock, R. Simard, L. Simon, F. Simos, N. Sinclair, J. Sinev, G. Singh, J. Singh, J. Singh, V. Sipos, R. Sippach, F.W. Sirri, G. Sitraka, A. Siyeon, K. Skarpaas, K. Smith, A. Smith, E. Smith, P. Smolik, J. Smy, M. Snider, E.L. Snopok, P. Soares Nunes, M. Sobel, H. Soderberg, M. Solano Salinas, C.J. Söldner-Rembold, S. Soleti, S. Solomey, N. Solovov, V. Sondheim, W.E. Sorel, M. Soto-Oton, J. Sousa, A. Soustruznik, K. Spagliardi, F. Spanu, M. Spitz, J. Spooner, N.J.C. Spurgeon, K. Staley, R. Stancari, M. Stanco, L. Stanley, R. Stein, R. Steiner, H.M. Stewart, J. Stillwell, B. Stock, J. Stocker, F. Stokes, T. Strait, M. Strauss, T. Striganov, S. Stuart, A. Suarez, J.G. Sullivan, H. Summers, D. Surdo, A. Susic, V. Suter, L. Sutera, C.M. Svoboda, R. Szczerbinska, B. Szelc, A.M. Talaga, R. Tanaka, H.A. Oregui, B.T. Tapper, A. Tariq, S. Tatar, E. Tayloe, R. Teklu, A.M. Tenti, M. Terao, K. Ternes, C.A. Terranova, F. Testera, G. Thea, A. Thompson, J.L. Thorn, C. Timm, S.C. Todd, J. Tonazzo, A. Torbunov, D. Torti, M. Tortola, M. Tortorici, F. Totani, D. Toups, M. Touramanis, C. Tosi, N. Travaglini, R. Trevor, J. Trilov, S. Trzaska, W.H. Tsai, Y.T. Tsamalaidze, Z. Tsang, K.V. Tsverava, N. Tufanli, S. Tull, C. Tyley, E. Tzanov, M. Uchida, M.A. Urheim, J. Usher, T. Uzunyan, S. Vagins, M.R. Vahle, P. Valdiviesso, G.A. Valencia, E. Valerio, P. Vallari, Z. Valle, J.W.F. Vallecorsa, S. Van Berg, R. Van De Water, R.G. Varanini, F. Vargas, D. Varner, G. Vasel, J. Vasina, S. Vasseur, G. Vaughan, N. Vaziri, K. Ventura, S. Verdugo, A. Vergani, S. Vermeulen, M.A. Verzocchi, M. Vicenzi, M. Vieira De Souza, H. Vignoli, C. Vilela, C. Viren, B. Vrba, T. Wachala, T. Waldron, A.V. Wallbank, M. Wang, H. Wang, J. Wang, L. Wang, M.H.L.S. Wang, Y. Wang, Y. Warburton, K. Warner, D. Wascko, M. Waters, D. Watson, A. Weatherly, P. Weber, A. Weber, M. Wei, H. Weinstein, A. Wenman, D. Wetstein, M. White, A. Whitehead, L.H. Whittington, D. Wilking, M.J. Wilkinson, C. Williams, Z. Wilson, F. Wilson, R.J. Wolcott, J. Wongjirad, T. Wood, A. Wood, K. Worcester, E. Worcester, M. Wret, C. Wu, W. Wu, W. Xiao, Y. Yandel, E. Yang, G. Yang, K. Yang, S. Yang, T. Yankelevich, A. Yershov, N. Yonehara, K. Young, T. Yu, B. Yu, H. Yu, J. Yuan, W. Zaki, R. Zalesak, J. Zambelli, L. Zamorano, B. Zani, A. Zazueta, L. Zeit, G. Zeller, G.P. Zennamo, J. Zeug, K. Zhang, C. Zhao, M. Zhivun, E. Zhu, G. Zilberman, P. Zimmerman, E.D. Zito, M. Zucchelli, S. Zuklin, J. Zutshi, V. Zwaska, R. DUNE Collaboration
Subjects: Physics::Instrumentation and Detectors, High Energy Physics::Experiment
Abstract: The Deep Underground Neutrino Experiment (DUNE) is an international, world-class experiment aimed at exploring fundamental questions about the universe that are at the forefront of astrophysics and particle physics research. DUNE will study questions pertaining to the preponderance of matter over antimatter in the early universe, the dynamics of supernovae, the subtleties of neutrino interaction physics, and a number of beyond the Standard Model topics accessible in a powerful neutrino beam. A critical component of the DUNE physics program involves the study of changes in a powerful beam of neutrinos, i.e., neutrino oscillations, as the neutrinos propagate a long distance. The experiment consists of a near detector, sited close to the source of the beam, and a far detector, sited along the beam at a large distance. This document, the DUNE Near Detector Conceptual Design Report (CDR), describes the design of the DUNE near detector and the science program that drives the design and technology choices. The goals and requirements underlying the design, along with projected performance are given. It serves as a starting point for a more detailed design that will be described in future documents. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Published: 2021

11. Supernova neutrino burst detection with the deep underground neutrino experiment: DUNE Collaboration

Author: Abi, B. Acciarri, R. Acero, M.A. Adamov, G. Adams, D. Adinolfi, M. Ahmad, Z. Ahmed, J. Alion, T. Alonso Monsalve, S. Alt, C. Anderson, J. Andreopoulos, C. Andrews, M.P. Andrianala, F. Andringa, S. Ankowski, A. Antonova, M. Antusch, S. Aranda-Fernandez, A. Ariga, A. Arnold, L.O. Arroyave, M.A. Asaadi, J. Aurisano, A. Aushev, V. Autiero, D. Azfar, F. Back, H. Back, J.J. Backhouse, C. Baesso, P. Bagby, L. Bajou, R. Balasubramanian, S. Baldi, P. Bambah, B. Barao, F. Barenboim, G. Barker, G.J. Barkhouse, W. Barnes, C. Barr, G. Barranco Monarca, J. Barros, N. Barrow, J.L. Bashyal, A. Basque, V. Bay, F. Alba, J.L.B. Beacom, J.F. Bechetoille, E. Behera, B. Bellantoni, L. Bellettini, G. Bellini, V. Beltramello, O. Belver, D. Benekos, N. Bento Neves, F. Berger, J. Berkman, S. Bernardini, P. Berner, R.M. Berns, H. Bertolucci, S. Betancourt, M. Bezawada, Y. Bhattacharjee, M. Bhuyan, B. Biagi, S. Bian, J. Biassoni, M. Biery, K. Bilki, B. Bishai, M. Bitadze, A. Blake, A. Blanco Siffert, B. Blaszczyk, F.D.M. Blazey, G.C. Blucher, E. Boissevain, J. Bolognesi, S. Bolton, T. Bonesini, M. Bongrand, M. Bonini, F. Booth, A. Booth, C. Bordoni, S. Borkum, A. Boschi, T. Bostan, N. Bour, P. Boyd, S.B. Boyden, D. Bracinik, J. Braga, D. Brailsford, D. Brandt, A. Bremer, J. Brew, C. Brianne, E. Brice, S.J. Brizzolari, C. Bromberg, C. Brooijmans, G. Brooke, J. Bross, A. Brunetti, G. Buchanan, N. Budd, H. Caiulo, D. Calafiura, P. Calcutt, J. Calin, M. Calvez, S. Calvo, E. Camilleri, L. Caminata, A. Campanelli, M. Caratelli, D. Carini, G. Carlus, B. Carniti, P. Caro Terrazas, I. Carranza, H. Castillo, A. Castromonte, C. Cattadori, C. Cavalier, F. Cavanna, F. Centro, S. Cerati, G. Cervelli, A. Cervera Villanueva, A. Chalifour, M. Chang, C. Chardonnet, E. Chatterjee, A. Chattopadhyay, S. Chaves, J. Chen, H. Chen, M. Chen, Y. Cherdack, D. Chi, C. Childress, S. Chiriacescu, A. Cho, K. Choubey, S. Christensen, A. Christian, D. Christodoulou, G. Church, E. Clarke, P. Coan, T.E. Cocco, A.G. Coelho, J.A.B. Conley, E. Conrad, J.M. Convery, M. Corwin, L. Cotte, P. Cremaldi, L. Cremonesi, L. Crespo-Anadón, J.I. Cristaldo, E. Cross, R. Cuesta, C. Cui, Y. Cussans, D. Dabrowski, M. da Motta, H. Da Silva Peres, L. David, C. David, Q. Davies, G.S. Davini, S. Dawson, J. De, K. De Almeida, R.M. Debbins, P. De Bonis, I. Decowski, M.P. de Gouvêa, A. De Holanda, P.C. De Icaza Astiz, I.L. Deisting, A. De Jong, P. Delbart, A. Delepine, D. Delgado, M. Dell-Acqua, A. De Lurgio, P. de Mello Neto, J.R.T. DeMuth, D.M. Dennis, S. Densham, C. Deptuch, G. De Roeck, A. De Romeri, V. De Vries, J.J. Dharmapalan, R. Dias, M. Diaz, F. Díaz, J.S. Di Domizio, S. Di Giulio, L. Ding, P. Di Noto, L. Distefano, C. Diurba, R. Diwan, M. Djurcic, Z. Dokania, N. Dolinski, M.J. Domine, L. Douglas, D. Drielsma, F. Duchesneau, D. Duffy, K. Dunne, P. Durkin, T. Duyang, H. Dvornikov, O. Dwyer, D.A. Dyshkant, A.S. Eads, M. Edmunds, D. Eisch, J. Emery, S. Ereditato, A. Escobar, C.O. Escudero Sanchez, L. Evans, J.J. Ewart, E. Ezeribe, A.C. Fahey, K. Falcone, A. Farnese, C. Farzan, Y. Felix, J. Fernandez-Martinez, E. Fernandez Menendez, P. Ferraro, F. Fields, L. Filkins, A. Filthaut, F. Fitzpatrick, R.S. Flanagan, W. Fleming, B. Flight, R. Fowler, J. Fox, W. Franc, J. Francis, K. Franco, D. Freeman, J. Freestone, J. Fried, J. Friedland, A. Fuess, S. Furic, I. Furmanski, A.P. Gago, A. Gallagher, H. Gallego-Ros, A. Gallice, N. Galymov, V. Gamberini, E. Gamble, T. Gandhi, R. Gandrajula, R. Gao, S. Garcia-Gamez, D. García-Peris, M.Á. Gardiner, S. Gastler, D. Ge, G. Gelli, B. Gendotti, A. Gent, S. Ghorbani-Moghaddam, Z. Gibin, D. Gil-Botella, I. Girerd, C. Giri, A.K. Gnani, D. Gogota, O. Gold, M. Gollapinni, S. Gollwitzer, K. Gomes, R.A. Gomez Bermeo, L.V. Gomez Fajardo, L.S. Gonnella, F. Gonzalez-Cuevas, J.A. Goodman, M.C. Goodwin, O. Goswami, S. Gotti, C. Goudzovski, E. Grace, C. Graham, M. Gramellini, E. Gran, R. Granados, E. Grant, A. Grant, C. Gratieri, D. Green, P. Green, S. Greenler, L. Greenwood, M. Greer, J. Griffith, W.C. Groh, M. Grudzinski, J. Grzelak, K. Gu, W. Guarino, V. Guenette, R. Guglielmi, A. Guo, B. Guthikonda, K.K. Gutierrez, R. Guzowski, P. Guzzo, M.M. Gwon, S. Habig, A. Hackenburg, A. Hadavand, H. Haenni, R. Hahn, A. Haigh, J. Haiston, J. Hamernik, T. Hamilton, P. Han, J. Harder, K. Harris, D.A. Hartnell, J. Hasegawa, T. Hatcher, R. Hazen, E. Heavey, A. Heeger, K.M. Heise, J. Hennessy, K. Henry, S. Hernandez Morquecho, M.A. Herner, K. Hertel, L. Hesam, A.S. Hewes, J. Higuera, A. Hill, T. Hillier, S.J. Himmel, A. Hoff, J. Hohl, C. Holin, A. Hoppe, E. Horton-Smith, G.A. Hostert, M. Hourlier, A. Howard, B. Howell, R. Huang, J. Huang, J. Hugon, J. Iles, G. Ilic, N. Iliescu, A.M. Illingworth, R. Ioannisian, A. Itay, R. Izmaylov, A. James, E. Jargowsky, B. Jediny, F. Jesùs-Valls, C. Ji, X. Jiang, L. Jiménez, S. Jipa, A. Joglekar, A. Johnson, C. Johnson, R. Jones, B. Jones, S. Jung, C.K. Junk, T. Jwa, Y. Kabirnezhad, M. Kaboth, A. Kadenko, I. Kamiya, F. Karagiorgi, G. Karcher, A. Karolak, M. Karyotakis, Y. Kasai, S. Kasetti, S.P. Kashur, L. Kazaryan, N. Kearns, E. Keener, P. Kelly, K.J. Kemp, E. Ketchum, W. Kettell, S.H. Khabibullin, M. Khotjantsev, A. Khvedelidze, A. Kim, D. King, B. Kirby, B. Kirby, M. Klein, J. Koehler, K. Koerner, L.W. Kohn, S. Koller, P.P. Kordosky, M. Kosc, T. Kose, U. Kostelecký, V.A. Kothekar, K. Krennrich, F. Kreslo, I. Kudenko, Y. Kudryavtsev, V.A. Kulagin, S. Kumar, J. Kumar, R. Kuruppu, C. Kus, V. Kutter, T. Lambert, A. Lande, K. Lane, C.E. Lang, K. Langford, T. Lasorak, P. Last, D. Lastoria, C. Laundrie, A. Lawrence, A. Lazanu, I. LaZur, R. Le, T. Learned, J. LeBrun, P. Lehmann Miotto, G. Lehnert, R. Leigui de Oliveira, M.A. Leitner, M. Leyton, M. Li, L. Li, S. Li, S.W. Li, T. Li, Y. Liao, H. Lin, C.S. Lin, S. Lister, A. Littlejohn, B.R. Liu, J. Lockwitz, S. Loew, T. Lokajicek, M. Lomidze, I. Long, K. Loo, K. Lorca, D. Lord, T. LoSecco, J.M. Louis, W.C. Luk, K.B. Luo, X. Lurkin, N. Lux, T. Luzio, V.P. MacFarland, D. Machado, A.A. Machado, P. Macias, C.T. Macier, J.R. Maddalena, A. Madigan, P. Magill, S. Mahn, K. Maio, A. Major, A. Maloney, J.A. Mandrioli, G. Maneira, J. Manenti, L. Manly, S. Mann, A. Manolopoulos, K. Manrique Plata, M. Marchionni, A. Marciano, W. Marfatia, D. Mariani, C. Maricic, J. Marinho, F. Marino, A.D. Marshak, M. Marshall, C. Marshall, J. Marteau, J. Martin-Albo, J. Martinez, N. Martinez Caicedo, D.A. Martynenko, S. Mason, K. Mastbaum, A. Masud, M. Matsuno, S. Matthews, J. Mauger, C. Mauri, N. Mavrokoridis, K. Mazza, R. Mazzacane, A. Mazzucato, E. McCluskey, E. McConkey, N. McFarland, K.S. McGrew, C. McNab, A. Mefodiev, A. Mehta, P. Melas, P. Mellinato, M. Mena, O. Menary, S. Mendez, H. Menegolli, A. Meng, G. Messier, M.D. Metcalf, W. Mewes, M. Meyer, H. Miao, T. Michna, G. Miedema, T. Migenda, J. Milincic, R. Miller, W. Mills, J. Milne, C. Mineev, O. Miranda, O.G. Miryala, S. Mishra, C.S. Mishra, S.R. Mislivec, A. Mladenov, D. Mocioiu, I. Moffat, K. Moggi, N. Mohanta, R. Mohayai, T.A. Mokhov, N. Molina, J. Molina Bueno, L. Montanari, A. Montanari, C. Montanari, D. Montano Zetina, L.M. Moon, J. Mooney, M. Moor, A. Moreno, D. Morgan, B. Morris, C. Mossey, C. Motuk, E. Moura, C.A. Mousseau, J. Mu, W. Mualem, L. Mueller, J. Muether, M. Mufson, S. Muheim, F. Muir, A. Mulhearn, M. Muramatsu, H. Murphy, S. Musser, J. Nachtman, J. Nagu, S. Nalbandyan, M. Nandakumar, R. Naples, D. Narita, S. Navas-Nicolás, D. Nayak, N. Nebot-Guinot, M. Necib, L. Negishi, K. Nelson, J.K. Nesbit, J. Nessi, M. Newbold, D. Newcomer, M. Newhart, D. Nichol, R. Niner, E. Nishimura, K. Norman, A. Norrick, A. Northrop, R. Novella, P. Nowak, J.A. Oberling, M. Olivares Del Campo, A. Olivier, A. Onel, Y. Onishchuk, Y. Ott, J. Pagani, L. Pakvasa, S. Palamara, O. Palestini, S. Paley, J.M. Pallavicini, M. Palomares, C. Pantic, E. Paolone, V. Papadimitriou, V. Papaleo, R. Papanestis, A. Paramesvaran, S. Parke, S. Parsa, Z. Parvu, M. Pascoli, S. Pasqualini, L. Pasternak, J. Pater, J. Patrick, C. Patrizii, L. Patterson, R.B. Patton, S.J. Patzak, T. Paudel, A. Paulos, B. Paulucci, L. Pavlovic, Z. Pawloski, G. Payne, D. Pec, V. Peeters, S.J.M. Penichot, Y. Pennacchio, E. Penzo, A. Peres, O.L.G. Perry, J. Pershey, D. Pessina, G. Petrillo, G. Petta, C. Petti, R. Piastra, F. Pickering, L. Pietropaolo, F. Pillow, J. Pinzino, J. Plunkett, R. Poling, R. Pons, X. Poonthottathil, N. Pordes, S. Potekhin, M. Potenza, R. Potukuchi, B.V.K.S. Pozimski, J. Pozzato, M. Prakash, S. Prakash, T. Prince, S. Prior, G. Pugnere, D. Qi, K. Qian, X. Raaf, J.L. Raboanary, R. Radeka, V. Rademacker, J. Radics, B. Rafique, A. Raguzin, E. Rai, M. Rajaoalisoa, M. Rakhno, I. Rakotondramanana, H.T. Rakotondravohitra, L. Ramachers, Y.A. Rameika, R. Ramirez Delgado, M.A. Ramson, B. Rappoldi, A. Raselli, G. Ratoff, P. Ravat, S. Razafinime, H. Real, J.S. Rebel, B. Redondo, D. Reggiani-Guzzo, M. Rehak, T. Reichenbacher, J. Reitzner, S.D. Renshaw, A. Rescia, S. Resnati, F. Reynolds, A. Riccobene, G. Rice, L.C.J. Rielage, K. Rigaut, Y. Rivera, D. Rochester, L. Roda, M. Rodrigues, P. Rodriguez Alonso, M.J. Rodriguez Rondon, J. Roeth, A.J. Rogers, H. Rosauro-Alcaraz, S. Rossella, M. Rout, J. Roy, S. Rubbia, A. Rubbia, C. Russell, B. Russell, J. Ruterbories, D. Saakyan, R. Sacerdoti, S. Safford, T. Sahu, N. Sala, P. Samios, N. Sanchez, M.C. Sanders, D.A. Sankey, D. Santana, S. Santos-Maldonado, M. Saoulidou, N. Sapienza, P. Sarasty, C. Sarcevic, I. Savage, G. Savinov, V. Scaramelli, A. Scarff, A. Scarpelli, A. Schaffer, T. Schellman, H. Schlabach, P. Schmitz, D. Scholberg, K. Schukraft, A. Segreto, E. Sensenig, J. Seong, I. Sergi, A. Sergiampietri, F. Sgalaberna, D. Shaevitz, M.H. Shafaq, S. Shamma, M. Sharma, H.R. Sharma, R. Shaw, T. Shepherd-Themistocleous, C. Shin, S. Shooltz, D. Shrock, R. Simard, L. Simos, N. Sinclair, J. Sinev, G. Singh, J. Singh, J. Singh, V. Sipos, R. Sippach, F.W. Sirri, G. Sitraka, A. Siyeon, K. Smargianaki, D. Smith, A. Smith, E. Smith, P. Smolik, J. Smy, M. Snopok, P. Soares Nunes, M. Sobel, H. Soderberg, M. Solano Salinas, C.J. Söldner-Rembold, S. Solomey, N. Solovov, V. Sondheim, W.E. Sorel, M. Soto-Oton, J. Sousa, A. Soustruznik, K. Spagliardi, F. Spanu, M. Spitz, J. Spooner, N.J.C. Spurgeon, K. Staley, R. Stancari, M. Stanco, L. Steiner, H.M. Stewart, J. Stillwell, B. Stock, J. Stocker, F. Stokes, T. Strait, M. Strauss, T. Striganov, S. Stuart, A. Summers, D. Surdo, A. Susic, V. Suter, L. Sutera, C.M. Svoboda, R. Szczerbinska, B. Szelc, A.M. Talaga, R. Tanaka, H.A. Tapia Oregui, B. Tapper, A. Tariq, S. Tatar, E. Tayloe, R. Teklu, A.M. Tenti, M. Terao, K. Ternes, C.A. Terranova, F. Testera, G. Thea, A. Thompson, J.L. Thorn, C. Timm, S.C. Tonazzo, A. Torti, M. Tórtola, M. Tortorici, F. Totani, D. Toups, M. Touramanis, C. Trevor, J. Trzaska, W.H. Tsai, Y.T. Tsamalaidze, Z. Tsang, K.V. Tsverava, N. Tufanli, S. Tull, C. Tyley, E. Tzanov, M. Uchida, M.A. Urheim, J. Usher, T. Vagins, M.R. Vahle, P. Valdiviesso, G.A. Valencia, E. Vallari, Z. Valle, J.W.F. Vallecorsa, S. Van Berg, R. Van de Water, R.G. Vanegas Forero, D. Varanini, F. Vargas, D. Varner, G. Vasel, J. Vasseur, G. Vaziri, K. Ventura, S. Verdugo, A. Vergani, S. Vermeulen, M.A. Verzocchi, M. Vieira de Souza, H. Vignoli, C. Vilela, C. Viren, B. Vrba, T. Wachala, T. Waldron, A.V. Wallbank, M. Wang, H. Wang, J. Wang, Y. Wang, Y. Warburton, K. Warner, D. Wascko, M. Waters, D. Watson, A. Weatherly, P. Weber, A. Weber, M. Wei, H. Weinstein, A. Wenman, D. Wetstein, M. While, M.R. White, A. Whitehead, L.H. Whittington, D. Wilking, M.J. Wilkinson, C. Williams, Z. Wilson, F. Wilson, R.J. Wolcott, J. Wongjirad, T. Wood, K. Wood, L. Worcester, E. Worcester, M. Wret, C. Wu, W. Wu, W. Xiao, Y. Yang, G. Yang, T. Yershov, N. Yonehara, K. Young, T. Yu, B. Yu, J. Zaki, R. Zalesak, J. Zambelli, L. Zamorano, B. Zani, A. Zazueta, L. Zeller, G.P. Zennamo, J. Zeug, K. Zhang, C. Zhao, M. Zhivun, E. Zhu, G. Zimmerman, E.D. Zito, M. Zucchelli, S. Zuklin, J. Zutshi, V. Zwaska, R.
Subjects: Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, High Energy Physics::Phenomenology, High Energy Physics::Experiment, Physics::Geophysics
Abstract: The deep underground neutrino experiment (DUNE), a 40-kton underground liquid argon time projection chamber experiment, will be sensitive to the electron-neutrino flavor component of the burst of neutrinos expected from the next Galactic core-collapse supernova. Such an observation will bring unique insight into the astrophysics of core collapse as well as into the properties of neutrinos. The general capabilities of DUNE for neutrino detection in the relevant few- to few-tens-of-MeV neutrino energy range will be described. As an example, DUNE’s ability to constrain the νe spectral parameters of the neutrino burst will be considered. © 2021, The Author(s).
Published: 2021

12. Searching for solar KDAR with DUNE

Author: Abud, A. Abed Abi, B. Acciarri, R. Acero, M. A. Adames, M. R. Adamov, G. Adams, D. Adinolfi, M. Aduszkiewicz, A. and Aguilar, J. Ahmad, Z. Ahmed, J. Ali-Mohammadzadeh, B. and Alion, T. Allison, K. Monsalve, S. Alonso Alrashed, M. and Alt, C. Alton, A. Amedo, P. Anderson, J. and Andreopoulos, C. Andreotti, M. Andrews, M. P. Andrianala, F. and Andringa, S. Anfimov, N. Ankowski, A. Antoniassi, M. and Antonova, M. Antoshkin, A. Antusch, S. Aranda-Fernandez, A. and Ariga, A. Arnold, L. O. Arroyave, M. A. Asaadi, J. and Asquith, L. Aurisano, A. Aushev, V Autiero, D. and Ayala-Torres, M. Azfar, F. Back, A. Back, H. Back, J. J. and Backhouse, C. Baesso, P. Bagaturia, I Bagby, L. and Balashov, N. Balasubramanian, S. Baldi, P. Baller, B. and Bambah, B. Barao, F. Barenboim, G. Barker, G. J. and Barkhouse, W. Barnes, C. Barr, G. Barranco Monarca, J. and Barros, A. Barros, N. Barrow, J. L. Basharina-Freshville, A. and Bashyal, A. Basque, V Belchior, E. Battat, J. B. R. and Battisti, F. Bay, F. Bazo Alba, J. L. Beacom, J. F. and Bechetoille, E. Behera, B. Bellantoni, L. Bellettini, G. and Bellini, V Beltramello, O. Belver, D. Benekos, N. and Benitez Montiel, C. Neves, F. Bento Berger, J. Berkman, S. and Bernardini, P. Berner, R. M. Berns, H. Bertolucci, S. and Betancourt, M. Betancur Rodriguez, A. Bevan, A. Bezerra, T. J. C. Bhatnagar, V Bhattacharjee, M. Bhuller, S. and Bhuyan, B. Biagi, S. Bian, J. Biassoni, M. Biery, K. and Bilki, B. Bishai, M. Bitadze, A. Blake, A. Blaszczyk, F. D. M. Blazey, G. C. Blucher, E. Boissevain, J. and Bolognesi, S. Bolton, T. Bomben, L. Bonesini, M. and Bongrand, M. Bonini, F. Booth, A. Booth, C. Boran, F. and Bordoni, S. Borkum, A. Boschi, T. Bostan, N. Bour, P. Bourgeois, C. Boyd, S. B. Boyden, D. Bracinik, J. and Braga, D. Brailsford, D. Branca, A. Brandt, A. Bremer, J. Brew, C. Brianne, E. Brice, S. J. Brizzolari, C. and Bromberg, C. Brooijmans, G. Brooke, J. Bross, A. and Brunetti, G. Brunetti, M. Buchanan, N. Budd, H. Butorov, I Cagnoli, I Caiulo, D. Calabrese, R. Calafiura, P. and Calcutt, J. Calin, M. Calvez, S. Calvo, E. Caminata, A. and Campanelli, M. Cankocak, K. Caratelli, D. Carini, G. and Carlus, B. Carneiro, M. F. Carniti, P. Terrazas, I. Caro and Carranza, H. Carroll, T. Castano Forero, J. F. Castillo, A. and Castromonte, C. Catano-Mur, E. Cattadori, C. Cavalier, F. Cavanna, F. Centro, S. Cerati, G. Cervelli, A. and Cervera Villanueva, A. Chalifour, M. Chappell, A. and Chardonnet, E. Charitonidis, N. Chatterjee, A. and Chattopadhyay, S. Chen, H. Chen, M. Chen, Y. Chen, Z. and Cheon, Y. Cherdack, D. Chi, C. Childress, S. and Chiriacescu, A. Chisnall, G. Cho, K. Choate, S. and Chokheli, D. Chong, P. S. Choubey, S. Christensen, A. and Christian, D. Christodoulou, G. Chukanov, A. Chung, M. and Church, E. Cicero, V Clarke, P. Coan, T. E. Cocco, A. G. and Coelho, J. A. B. Conley, E. Conley, R. Conrad, J. M. and Convery, M. Copello, S. Corwin, L. Valentim, R. and Cremaldi, L. Cremonesi, L. Crespo-Anadon, I, J. Crisler, M. and Cristaldo, E. Cross, R. Cudd, A. Cuesta, C. Cui, Y. and Cussans, D. Dalager, O. da Motta, H. Peres, L. Da Silva and David, C. David, Q. Davies, G. S. Davini, S. Dawson, J. De, K. Debbins, P. De Bonis, I Decowski, M. P. de Gouvea, A. De Holanda, P. C. Astiz, I. L. De Icaza Deisting, A. De Jong, P. Delbart, A. Delepine, D. Delgado, M. and Dell'Acqua, A. De Lurgio, P. de Mello Neto, J. R. T. DeMuth, D. M. Dennis, S. Densham, C. Deptuch, G. W. De Roeck, A. and De Romeri, V De Souza, G. Devi, R. Dharmapalan, R. and Dias, M. Diaz, F. Diaz, J. S. Di Domizio, S. Di Giulio, L. Ding, P. Di Noto, L. Distefano, C. Diurba, R. and Diwan, M. Djurcic, Z. Doering, D. Dolan, S. Dolek, F. and Dolinski, M. J. Domine, L. Douglas, D. Douillet, D. and Drake, G. Drielsma, F. Duarte, L. Duchesneau, D. Duffy, K. Dunne, P. Durkin, T. Duyang, H. Dvornikov, O. and Dwyer, D. A. Dyshkant, A. S. Eads, M. Earle, A. Edmunds, D. Eisch, J. Emberger, L. Emery, S. Ereditato, A. and Erjavec, T. Escobar, C. O. Eurin, G. Evans, J. J. Ewart, E. Ezeribe, A. C. Fahey, K. Falcone, A. Fani, M. and Farnese, C. Farzan, Y. Fedoseev, D. Felix, J. Feng, Y. and Fernandez-Martinez, E. Fernandez Menendez, P. Fernandez Morales, M. Ferraro, F. Fields, L. Filip, P. Filthaut, F. Fiorentini, A. Fiorini, M. Fitzpatrick, R. S. and Flanagan, W. Fleming, B. Flight, R. Forero, V, D. and Fowler, J. Fox, W. Franc, J. Francis, K. Franco, D. and Freeman, J. Freestone, J. Fried, J. Friedland, A. and Robayo, F. Fuentes Fuess, S. Furic, I. K. Furmanski, A. P. and Gabrielli, A. Gago, A. Gallagher, H. Gallas, A. and Gallego-Ros, A. Gallice, N. Galymov, V Gamberini, E. and Gamble, T. Ganacim, F. Gandhi, R. Gandrajula, R. Gao, F. and Gao, S. Garcia, A. C. B. Garcia-Gamez, D. Garcia-Peris, A. Gardiner, S. Gastler, D. Gauvreau, J. Ge, G. and Gelli, B. Gendotti, A. Gent, S. Ghorbani-Moghaddam, Z. and Giammaria, P. Giammaria, T. Gibin, D. Gil-Botella, I and Gilligan, S. Girerd, C. Giri, A. K. Gnani, D. Gogota, O. and Gold, M. Gollapinni, S. Gollwitzer, K. Gomes, R. A. and Gomez Bermeo, V, L. Gomez Fajardo, L. S. Gonnella, F. and Gonzalez-Cuevas, J. A. Gonzalez Diaz, D. Gonzalez-Lopez, M. and Goodman, M. C. Goodwin, O. Goswami, S. Gotti, C. and Goudzovski, E. Grace, C. Graham, M. Gran, R. Granados, E. Granger, P. Grant, A. Grant, C. Gratieri, D. and Green, P. Greenler, L. Greer, J. Grenard, J. Griffith, W. C. Groh, M. Grudzinski, J. Grzelak, K. Gu, W. and Guardincerri, E. Guarino, V Guarise, M. Guenette, R. and Guerard, E. Guerzoni, M. Guglielmi, A. Guo, B. and Guthikonda, K. K. Gutierrez, R. Guzowski, P. Guzzo, M. M. and Gwon, S. Ha, C. Habig, A. Hadavand, H. Haenni, R. and Hahn, A. Haiston, J. Hamacher-Baumann, P. Hamernik, T. and Hamilton, P. Han, J. Harris, D. A. Hartnell, J. and Harton, J. Hasegawa, T. Hasnip, C. Hatcher, R. Hatfield, K. W. Hatzikoutelis, A. Hayes, C. Hayrapetyan, K. Hays, J. Hazen, E. He, M. Heavey, A. Heeger, K. M. Heise, J. Hennessy, K. Henry, S. Morquecho, M. A. Hernandez and Herner, K. Hertel, L. Hewes, J. Higuera, A. Hill, T. and Hillier, S. J. Himmel, A. Hirsch, L. R. Ho, J. Hoff, J. and Holin, A. Hoppe, E. Horton-Smith, G. A. Hostert, M. and Hourlier, A. Howard, B. Howell, R. Hristova, I Hronek, M. S. Huang, J. Huang, J. Hugon, J. Iles, G. Ilic, N. Iliescu, A. M. Illingworth, R. Ingratta, G. and Ioannisian, A. Isenhower, L. Itay, R. Izmaylov, A. and Jackson, C. M. Jain, V James, E. Jang, W. Jargowsky, B. and Jediny, F. Jena, D. Jeong, Y. S. Jesus-Valls, C. Ji, X. Jiang, L. Jimenez, S. Jipa, A. Johnson, R. and Johnston, N. Jones, B. Jones, S. B. Judah, M. Jung, C. K. Junk, T. Jwa, Y. Kabirnezhad, M. Kaboth, A. and Kadenko, I Kalra, D. Kakorin, I Kalitkina, A. Kamiya, F. and Kaneshige, N. Karagiorgi, G. Karaman, G. Karcher, A. and Karolak, M. Karyotakis, Y. Kasai, S. Kasetti, S. P. and Kashur, L. Kazaryan, N. Kearns, E. Keener, P. Kelly, K. J. Kemp, E. Kemularia, O. Ketchum, W. Kettell, S. H. and Khabibullin, M. Khotjantsev, A. Khvedelidze, A. Kim, D. and King, B. Kirby, B. Kirby, M. Klein, J. Koehler, K. and Koerner, L. W. Kohn, S. Koller, P. P. Kolupaeva, L. and Korablev, D. Kordosky, M. Kosc, T. Kose, U. Kostelecky, V. A. Kothekar, K. Krennrich, F. Kreslo, I Kropp, W. and Kudenko, Y. Kudryavtsev, V. A. Kulagin, S. Kumar, J. and Kumar, P. Kunze, P. Kuruppu, C. Kus, V Kutter, T. and Kvasnicka, J. Kwak, D. Lambert, A. Land, B. J. Lande, K. and Lane, C. E. Lang, K. Langford, T. Langstaff, M. and Larkin, J. Lasorak, P. Last, D. Lastoria, C. Laundrie, A. Laurenti, G. Lawrence, A. Lazanu, I LaZur, R. and Lazzaroni, M. Le, T. Leardini, S. Learned, J. LeBrun, P. and LeCompte, T. Lee, C. Lee, S. Y. Miotto, G. Lehmann and Lehnert, R. de Oliveira, M. A. Leigui Leitner, M. Lepin, L. M. Li, L. Li, S. W. Li, T. Li, Y. Liao, H. Lin, C. S. Lin, Q. Lin, S. Ling, J. Lister, A. and Littlejohn, B. R. Liu, J. Lockwitz, S. Loew, T. and Lokajicek, M. Lomidze, I Long, K. Loo, K. Lord, T. and LoSecco, J. M. Louis, W. C. Lu, X-G Luk, K. B. Luo, X. and Luppi, E. Lurkin, N. Lux, T. Luzio, V. P. and MacFarlane, D. Machado, A. A. Machado, P. Macias, C. T. and Macier, J. R. Maddalena, A. Madera, A. Madigan, P. and Magill, S. Mahn, K. Maio, A. Major, A. Maloney, J. A. and Mandrioli, G. Mandujano, R. C. Maneira, J. Manenti, L. and Manly, S. Mann, A. Manolopoulos, K. Plata, M. Manrique and Manyam, V. N. Manzanillas, L. Marchan, M. Marchionni, A. and Marciano, W. Marfatia, D. Mariani, C. Maricic, J. and Marie, R. Marinho, F. Marino, A. D. Marsden, D. Marshak, M. Marshall, C. M. Marshall, J. Marteau, J. Martin-Albo, J. Martinez, N. Caicedo, D. A. Martinez Martynenko, S. and Mascagna, V Mason, K. Mastbaum, A. Masud, M. Matichard, F. Matsuno, S. Matthews, J. Mauger, C. Mauri, N. and Mavrokoridis, K. Mawby, I Mazza, R. Mazzacane, A. and Mazzucato, E. McAskill, T. McCluskey, E. McConkey, N. and McFarland, K. S. McGrew, C. McNab, A. Mefodiev, A. and Mehta, P. Melas, P. Mena, O. Menary, S. Mendez, H. and Mendez, P. Menegolli, A. Meng, G. Messier, M. D. and Metcalf, W. Mettler, T. Mewes, M. Meyer, H. Miao, T. and Michna, G. Miedema, T. Mikola, V Milincic, R. Miller, G. and Miller, W. Mills, J. Milne, C. Mineev, O. Miranda, O. G. Miryala, S. Mishra, C. S. Mishra, S. R. Mislivec, A. Mladenov, D. Mocioiu, I Moffat, K. Moggi, N. and Mohanta, R. Mohayai, T. A. Mokhov, N. Molina, J. Bueno, L. Molina Montagna, E. Montanari, A. Montanari, C. and Montanari, D. Zetina, L. M. Montano Moon, J. Moon, S. H. and Mooney, M. Moor, A. F. Moreno, D. Morris, C. Mossey, C. and Motuk, E. Moura, C. A. Mousseau, J. Mouster, G. Mu, W. Mualem, L. Mueller, J. Muether, M. Mufson, S. and Muheim, F. Muir, A. Mulhearn, M. Munford, D. Muramatsu, H. Murphy, S. Musser, J. Nachtman, J. Nagu, S. and Nalbandyan, M. Nandakumar, R. Naples, D. Narita, S. and Nath, A. Navas-Nicolas, D. Navrer-Agasson, A. Nayak, N. and Nebot-Guinot, M. Negishi, K. Nelson, J. K. Nesbit, J. and Nessi, M. Newbold, D. Newcomer, M. Newhart, D. Newton, H. Nichol, R. Nicolas-Arnaldos, F. Niner, E. Nishimura, K. Norman, A. Norrick, A. Northrop, R. Novella, P. and Nowak, J. A. Oberling, M. Ochoa-Ricoux, J. P. Del Campo, A. Olivares Olivier, A. Olshevskiy, A. Onel, Y. Onishchuk, Y. Ott, J. Pagani, L. Pakvasa, S. Palacio, G. and Palamara, O. Palestini, S. Paley, J. M. Pallavicini, M. and Palomares, C. Palomino-Gallo, J. L. Vazquez, W. Panduro and Pantic, E. Paolone, V Papadimitriou, V Papaleo, R. and Papanestis, A. Paramesvaran, S. Parke, S. Parozzi, E. and Parsa, Z. Parvu, M. Pascoli, S. Pasqualini, L. and Pasternak, J. Pater, J. Patrick, C. Patrizii, L. and Patterson, R. B. Patton, S. J. Patzak, T. Paudel, A. and Paulos, B. Paulucci, L. Pavlovic, Z. Pawloski, G. Payne, D. Pec, V Peeters, S. J. M. Pennacchio, E. Penzo, A. and Peres, O. L. G. Perry, J. Pershey, D. Pessina, G. and Petrillo, G. Petta, C. Petti, R. Pia, V Piastra, F. and Pickering, L. Pietropaolo, F. Plunkett, R. Poling, R. and Pons, X. Poonthottathil, N. Poppi, F. Pordes, S. Porter, J. Potekhin, M. Potenza, R. Potukuchi, B. V. K. S. and Pozimski, J. Pozzato, M. Prakash, S. Prakash, T. Prest, M. Prince, S. Psihas, F. Pugnere, D. Qian, X. and Bazetto, M. C. Queiroga Raaf, J. L. Radeka, V Rademacker, J. and Radics, B. Rafique, A. Raguzin, E. Rai, M. and Rajaoalisoa, M. Rakhno, I Rakotonandrasana, A. and Rakotondravohitra, L. Ramachers, Y. A. Rameika, R. Delgado, M. A. Ramirez Ramson, B. Rappoldi, A. Raselli, G. and Ratoff, P. Raut, S. Razakamiandra, R. F. Rea, E. Real, J. S. Rebel, B. Reggiani-Guzzo, M. Rehak, T. and Reichenbacher, J. Reitzner, S. D. Sfar, H. Rejeb Renshaw, A. and Rescia, S. Resnati, F. Reynolds, A. Ribas, M. and Riboldi, S. Riccio, C. Riccobene, G. Rice, L. C. J. and Ricol, J. Rigamonti, A. Rigaut, Y. Rivera, D. Robert, A. and Rochester, L. Roda, M. Rodrigues, P. Alonso, M. J. Rodriguez Rodriguez Bonilla, E. Rondon, J. Rodriguez and Rosauro-Alcaraz, S. Rosenberg, M. Rosier, P. Roskovec, B. and Rossella, M. Rossi, M. Rott, C. Rout, J. Roy, P. and Roy, S. Rubbia, A. Rubbia, C. Rubio, F. C. Russell, B. and Ruterbories, D. Rybnikov, A. Saa-Hernandez, A. Saakyan, R. Sacerdoti, S. Safford, T. Sahu, N. Sala, P. and Samios, N. Samoylov, O. Sanchez, M. C. Sandberg, V and Sanders, D. A. Sankey, D. Santana, S. Santos-Maldonado, M. and Saoulidou, N. Sapienza, P. Sarasty, C. Sarcevic, I and Savage, G. Savinov, V Scaramelli, A. Scarff, A. and Scarpelli, A. Schaffer, T. Schellman, H. Schifano, S. and Schlabach, P. Schmitz, D. Scholberg, K. Schukraft, A. and Segreto, E. Selyunin, A. Senise, C. R. Sensenig, J. and Seoane, M. Seong, I Sergi, A. Sgalaberna, D. Shaevitz, M. H. Shafaq, S. Shamma, M. Sharankova, R. Sharma, H. R. and Sharma, R. Kumar, R. Shaw, T. Shepherd-Themistocleous, C. Sheshukov, A. Shin, S. Shoemaker, I Shooltz, D. and Shrock, R. Siegel, H. Simard, L. Simon, F. Sinclair, J. and Sinev, G. Singh, J. Singh, J. Singh, L. Singh, V and Sipos, R. Sippach, F. W. Sirri, G. Sitraka, A. Siyeon, K. Skarpaas, K. Smith, A. Smith, E. Smith, P. and Smolik, J. Smy, M. Snider, E. L. Snopok, P. and Snowden-Ifft, D. Nunes, M. Soares Sobel, H. Soderberg, M. and Sokolov, S. Solano Salinas, C. J. Soldner-Rembold, S. and Soleti, S. R. Solomey, N. Solovov, V Sondheim, W. E. and Sorel, M. Sotnikov, A. Soto-Oton, J. Sousa, A. and Soustruznik, K. Spagliardi, F. Spanu, M. Spitz, J. and Spooner, N. J. C. Spurgeon, K. Staley, R. Stancari, M. and Stanco, L. Stanley, R. Stein, R. Steiner, H. M. Lisboa, A. F. Steklain Stewart, J. Stillwell, B. Stock, J. and Stocker, F. Stokes, T. Strait, M. Strauss, T. Striganov, S. Stuart, A. Suarez, J. G. Sullivan, H. Summers, D. and Surdo, A. Susic, V Suter, L. Sutera, C. M. Svoboda, R. and Szczerbinska, B. Szelc, A. M. Tanaka, H. A. Oregui, B. Tapia Tapper, A. Tariq, S. Tatar, E. Tayloe, R. and Teklu, A. M. Tenti, M. Terao, K. Ternes, C. A. and Terranova, F. Testera, G. Thakore, T. Thea, A. Thompson, J. L. Thorn, C. Timm, S. C. Tishchenko, V Todd, J. and Tomassetti, L. Tonazzo, A. Torbunov, D. Torti, M. and Tortola, M. Tortorici, F. Tosi, N. Totani, D. Toups, M. and Touramanis, C. Travaglini, R. Trevor, J. Trilov, S. and Tripathi, A. Trzaska, W. H. Tsai, Y. Tsai, Y-T and Tsamalaidze, Z. Tsang, V, K. Tsverava, N. Tufanli, S. and Tull, C. Tyley, E. Tzanov, M. Uboldi, L. Uchida, M. A. and Urheim, J. Usher, T. Uzunyan, S. Vagins, M. R. and Vahle, P. Valdiviesso, G. A. Valencia, E. Vallari, Z. and Vallazza, E. Valle, J. W. F. Vallecorsa, S. Van Berg, R. and Van de Water, R. G. Varanini, F. Vargas, D. Varner, G. and Vasel, J. Vasina, S. Vasseur, G. Vaughan, N. Vaziri, K. and Ventura, S. Verdugo, A. Vergani, S. Vermeulen, M. A. and Verzocchi, M. Vicenzi, M. de Souza, H. Vieira Vignoli, C. and Vilela, C. Viren, B. Vrba, T. Wachala, T. Waldron, V, A. Wallbank, M. Wallis, C. Wang, H. Wang, J. and Wang, L. Wang, M. H. L. S. Wang, Y. Wang, Y. Warburton, K. Warner, D. Wascko, M. O. Waters, D. Watson, A. and Weatherly, P. Weber, A. Weber, M. Wei, H. Weinstein, A. and Wenman, D. Wetstein, M. White, A. Whitehead, L. H. and Whittington, D. Wilking, M. J. Wilkinson, C. Williams, Z. and Wilson, F. Wilson, R. J. Wisniewski, W. Wolcott, J. and Wongjirad, T. Wood, A. Wood, K. Worcester, E. Worcester, M. Wret, C. Wu, W. Wu, W. Xiao, Y. Xie, F. and Yandel, E. Yang, G. Yang, K. Yang, S. Yang, T. and Yankelevich, A. Yershov, N. Yonehara, K. Young, T. Yu, B. Yu, H. Yu, H. Yu, J. Yuan, W. Zaki, R. and Zalesak, J. Zambelli, L. Zamorano, B. Zani, A. Zazueta, L. Zeller, G. P. Zennamo, J. Zeug, K. Zhang, C. and Zhao, M. Zhivun, E. Zhu, G. Zilberman, P. Zimmerman, E. D. Zito, M. Zucchelli, S. Zuklin, J. Zutshi, V and Zwaska, R. DUNE Collaboration
Subjects: High Energy Physics::Experiment
Abstract: The observation of 236 MeV muon neutrinos from kaon-decay-at-rest (KDAR) originating in the core of the Sun would provide a unique signature of dark matter annihilation. Since excellent angle and energy reconstruction are necessary to detect this monoenergetic, directional neutrino flux, DUNE with its vast volume and reconstruction capabilities, is a promising candidate for a KDAR neutrino search. In this work, we evaluate the proposed KDAR neutrino search strategies by realistically modeling both neutrino-nucleus interactions and the response of DUNE. We find that, although reconstruction of the neutrino energy and direction is difficult with current techniques in the relevant energy range, the superb energy resolution, angular resolution, and particle identification offered by DUNE can still permit great signal/background discrimination. Moreover, there are non-standard scenarios in which searches at DUNE for KDAR in the Sun can probe dark matter interactions.
Published: 2021

13. 'Doctor, how long will it take?' Results from an historical cohort on surgical pressure ulcer healing delay and related factors in persons with spinal cord injury

Author: Isabelle Almeras, Nicolas Frasson, Jean-Pierre Daurès, Isabelle Laffont, Hélène Rouays, Christian Herlin, C. Verollet, Arnaud Dupeyron, C. Mauri, Anthony Gelis, Juliette Morel, and Bouali Amara
Subjects: Adult, Male, medicine.medical_specialty, Time Factors, medicine.medical_treatment, Dermatology, Pathology and Forensic Medicine, Sepsis, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Acute care, Medicine, Humans, Risk factor, Spinal cord injury, Spinal Cord Injuries, Retrospective Studies, Pressure Ulcer, Wound Healing, Rehabilitation, 030504 nursing, business.industry, Retrospective cohort study, Middle Aged, medicine.disease, Surgery, Female, France, 0305 other medical science, Complication, business, Wound healing
Abstract: Background Flap surgery for deep pelvic pressure ulcers has already shown its effectiveness. Most studies relating to the postoperative period assessed complications rates and associated risk factors, but none focused on delayed wound healing. The objective of this study was to describe wound healing delay after primary flap surgery in patients with spinal cord injury (SCI) and to assess associated risk factors. Methods This observational retrospective study based on medical charts included all persons with SCI operated for primary flap surgery for pelvic PU in the Herault department of France between 2006 and 2014. Overall, 100 biomedical, psychological, socioeconomics and care management factors were studied. The primary outcome was wound healing delay, defined as time from surgery to complete cutaneous closure. Results 85 patients were included. Median healing time was 48 days (R: 20–406). Healing rate was 70% at 3 months and 90% at 4 months. After a multivariate analysis three factors were significantly associated with delayed wound healing: duration of hospitalization in the acute care unit (HR = 2.68; p = 0.004), local post-operative complication (HR = 10.75; p = 0.02), and post-operative sepsis (HR = 2.18; p = 0.02). Conclusion After primary skin flap surgery for PU in persons with SCI, delayed wound healing is related to local or general complications as well as care management organization. The risk of delayed wound healing justifies the implementation of a coordinated pre-operative management to prevent complications and a structured care network for an earlier transfer to a SCI rehabilitation center.
Published: 2020

14. Volume IV The DUNE far detector single-phase technology

Author: Abi, B. Acciarri, R. Acero, M. A. Adamov, G. Adams, D. and Adinolfi, M. Ahmad, Z. Ahmed, J. Alion, T. Monsalve, S. Alonso Alt, C. Anderson, J. Andreopoulos, C. Andrews, M. Andrianala, F. Andringa, S. Ankowski, A. Antonova, M. and Antusch, S. Aranda-Fernandez, A. Ariga, A. Arnold, L. O. and Arroyave, M. A. Asaadi, J. Aurisano, A. Aushev, V and Autiero, D. Azfar, F. Back, H. Back, J. J. Backhouse, C. and Baesso, P. Bagby, L. Bajou, R. Balasubramanian, S. and Baldi, P. Bambah, B. Barao, F. Barenboim, G. Barker, G. and Barkhouse, W. Barnes, C. Barr, G. Barranco Monarca, J. and Barros, N. Barrow, J. L. Bashyal, A. Basque, V Bay, F. Bazo Alba, J. Beacom, J. F. Bechetoille, E. Behera, B. Bellantoni, L. Bellettini, G. Bellini, V Beltramello, O. Belver, D. Benekos, N. Neves, F. Bento Berger, J. and Berkman, S. Bernardini, P. Berner, R. M. Berns, H. and Bertolucci, S. Betancourt, M. Bezawada, Y. Bhattacharjee, M. and Bhuyan, B. Biagi, S. Bian, J. Biassoni, M. Biery, K. and Bilki, B. Bishai, M. Bitadze, A. Blake, A. Siffert, B. Blanco Blaszczyk, F. Blazey, G. Blucher, E. and Boissevain, J. Bolognesi, S. Bolton, T. Bonesini, M. and Bongrand, M. Bonini, F. Booth, A. Booth, C. Bordoni, S. and Borkum, A. Boschi, T. Bostan, N. Bour, P. Boyd, S. and Boyden, D. Bracinik, J. Braga, D. Brailsford, D. and Brandt, A. Bremer, J. Brew, C. Brianne, E. Brice, S. J. and Brizzolari, C. Bromberg, C. Brooijmans, G. Brooke, J. and Bross, A. Brunetti, G. Buchanan, N. Budd, H. Caiulo, D. Calafiura, P. Calcutt, J. Calin, M. Calvez, S. and Calvo, E. Camilleri, L. Caminata, A. Campanelli, M. and Caratelli, D. Carini, G. Carlus, B. Carniti, P. and Terrazas, I. Caro Carranza, H. Castillo, A. Castromonte, C. and Cattadori, C. Cavalier, F. Cavanna, F. Centro, S. and Cerati, G. Cervelli, A. Cervera Villanueva, A. Chalifour, M. and Chang, C. Chardonnet, E. Chatterjee, A. Chattopadhyay, S. Chaves, J. Chen, H. Chen, M. Chen, Y. Cherdack, D. Chi, C. Childress, S. Chiriacescu, A. Cho, K. and Choubey, S. Christensen, A. Christian, D. Christodoulou, G. and Church, E. Clarke, P. Coan, T. E. Cocco, A. G. and Coelho, J. Conley, E. Conrad, J. Convery, M. Corwin, L. and Cotte, P. Cremaldi, L. Cremonesi, L. Crespo-Anadon, I, J. Cristaldo, E. Cross, R. Cuesta, C. Cui, Y. and Cussans, D. Dabrowski, M. Da Motta, H. Peres, L. Da Silva and David, Q. Davies, G. S. Davini, S. Dawson, J. De, K. and De Almeida, R. M. Debbins, P. De Bonis, I Decowski, M. and De Gouvea, A. De Holanda, P. C. Astiz, I. L. De Icaza and Deisting, A. De Jong, P. Delbart, A. Delepine, D. and Delgado, M. Dell'Acqua, A. De Lurgio, P. De Mello Neto, J. R. DeMuth, D. M. Dennis, S. Densham, C. Deptuch, G. and De Roeck, A. De Romeri, V De Vries, J. Dharmapalan, R. and Dias, M. Diaz, F. Diaz, J. Di Domizio, S. Di Giulio, L. and Ding, P. Di Noto, L. Distefano, C. Diurba, R. Diwan, M. Djurcic, Z. Dokania, N. Dolinski, M. Domine, L. and Douglas, D. Drielsma, F. Duchesneau, D. Duffy, K. Dunne, P. Durkin, T. Duyang, H. Dvornikov, O. Dwyer, D. and Dyshkant, A. Eads, M. Edmunds, D. Eisch, J. Emery, S. and Ereditato, A. Escobar, C. Sanchez, L. Escudero Evans, J. J. Ewart, E. Ezeribe, A. C. Fahey, K. Falcone, A. and Farnese, C. Farzan, Y. Felix, J. Fernandez-Martinez, E. and Fernandez Menendez, P. Ferraro, F. Fields, L. Filkins, A. and Filthaut, F. Fitzpatrick, R. S. Flanagan, W. Fleming, B. and Flight, R. Fowler, J. Fox, W. Franc, J. Francis, K. and Franco, D. Freeman, J. Freestone, J. Fried, J. and Friedland, A. Fuess, S. Furic, I Furmanski, A. P. Gago, A. Gallagher, H. Gallego-Ros, A. Gallice, N. Galymov, V and Gamberini, E. Gamble, T. Gandhi, R. Gandrajula, R. and Gao, S. Garcia-Gamez, D. Garcia-Peris, M. A. Gardiner, S. and Gastler, D. Ge, G. Gelli, B. Gendotti, A. Gent, S. and Ghorbani-Moghaddam, Z. Gibin, D. Gil-Botella, I Girerd, C. Giri, A. Gnani, D. Gogota, O. Gold, M. and Gollapinni, S. Gollwitzer, K. Gomes, R. A. Gomez Bermeo, L. and Gomez Fajardo, L. S. Gonnella, F. Gonzalez-Cuevas, J. and Goodman, M. C. Goodwin, O. Goswami, S. Gotti, C. and Goudzovski, E. Grace, C. Graham, M. Gramellini, E. Gran, R. Granados, E. Grant, A. Grant, C. Gratieri, D. and Green, P. Green, S. Greenler, L. Greenwood, M. Greer, J. and Griffith, C. Groh, M. Grudzinski, J. Grzelak, K. Gu, W. Guarino, V Guenette, R. Guglielmi, A. Guo, B. and Guthikonda, K. Gutierrez, R. Guzowski, P. Guzzo, M. M. and Gwon, S. Habig, A. Hackenburg, A. Hadavand, H. Haenni, R. Hahn, A. Haigh, J. Haiston, J. Hamernik, T. and Hamilton, P. Han, J. Harder, K. Harris, D. A. Hartnell, J. Hasegawa, T. Hatcher, R. Hazen, E. Heavey, A. and Heeger, K. M. Hennessy, K. Henry, S. Hernandez Morquecho, M. and Herner, K. Hertel, L. Hesam, A. S. Hewes, J. and Pichardo, A. Higuera Hill, T. Hillier, S. J. Himmel, A. and Hoff, J. Hohl, C. Holin, A. Hoppe, E. Horton-Smith, G. A. Hostert, M. Hourlier, A. Howard, B. Howell, R. and Huang, J. Huang, J. Hugon, J. Iles, G. Iliescu, A. M. and Illingworth, R. Ioannisian, A. Itay, R. Izmaylov, A. and James, E. Jargowsky, B. Jediny, F. Jesus-Valls, C. Ji, X. Jiang, L. Jimenez, S. Jipa, A. Joglekar, A. and Johnson, C. Johnson, R. Jones, B. Jones, S. Jung, C. and Junk, T. Jwa, Y. Kabirnezhad, M. Kaboth, A. Kadenko, I and Kamiya, F. Karagiorgi, G. Karcher, A. Karolak, M. and Karyotakis, Y. Kasai, S. Kasetti, S. P. Kashur, L. and Kazaryan, N. Kearns, E. Keener, P. Kelly, K. J. Kemp, E. and Ketchum, W. Kettell, S. Khabibullin, M. Khotjantsev, A. and Khvedelidze, A. Kim, D. King, B. Kirby, B. Kirby, M. and Klein, J. Koehler, K. Koerner, L. W. Kohn, S. and Koller, P. P. Kordosky, M. Kosc, T. Kose, U. Kostelecky, V Kothekar, K. Krennrich, F. Kreslo, I Kudenko, Y. and Kudryavtsev, V Kulagin, S. Kumar, J. Kumar, R. Kuruppu, C. Kus, V Kutter, T. Lambert, A. Lande, K. Lane, C. E. Lang, K. Langford, T. Lasorak, P. Last, D. and Lastoria, C. Laundrie, A. Lawrence, A. Lazanu, I LaZur, R. Le, T. Learned, J. LeBrun, P. Miotto, G. Lehmann and Lehnert, R. de Oliveira, M. Leigui Leitner, M. Leyton, M. and Li, L. Li, S. Li, S. Li, T. Li, Y. Liao, H. and Lin, C. Lin, S. Lister, A. Littlejohn, B. R. Liu, J. and Lockwitz, S. Loew, T. Lokajicek, M. Lomidze, I Long, K. and Loo, K. Lorca, D. Lord, T. LoSecco, J. Louis, W. C. and Luk, K. Luo, X. Lurkin, N. Lux, T. Luzio, V. P. and MacFarland, D. Machado, A. Machado, P. Macias, C. and Macier, J. Maddalena, A. Madigan, P. Magill, S. Mahn, K. and Maio, A. Maloney, J. A. Mandrioli, G. Maneira, J. C. and Manenti, L. Manly, S. Mann, A. Manolopoulos, K. Plata, M. Manrique Marchionni, A. Marciano, W. Marfatia, D. and Mariani, C. Maricic, J. Marinho, F. Marino, A. D. and Marshak, M. Marshall, C. Marshall, J. Marteau, J. and Martin-Albo, J. Martinez, N. Caicedo, D. A. Martinez and Martynenko, S. Mason, K. Mastbaum, A. Masud, M. Matsuno, S. Matthews, J. Mauger, C. Mauri, N. Mavrokoridis, K. and Mazza, R. Mazzacane, A. Mazzucato, E. McCluskey, E. and McConkey, N. McFarland, K. S. McGrew, C. McNab, A. and Mefodiev, A. Mehta, P. Melas, P. Mellinato, M. Mena, O. and Menary, S. Mendez, H. Menegolli, A. Meng, G. and Messier, M. Metcalf, W. Mewes, M. Meyer, H. Miao, T. and Michna, G. Miedema, T. Migenda, J. Milincic, R. Miller, W. Mills, J. Milne, C. Mineev, O. Miranda, O. G. and Miryala, S. Mishra, C. Mishra, S. Mislivec, A. Mladenov, D. Mocioiu, I Moffat, K. Moggi, N. Mohanta, R. and Mohayai, T. A. Mokhov, N. Molina, J. A. Bueno, L. Molina and Montanari, A. Montanari, C. Montanari, D. Montano Zetina, L. M. Moon, J. Mooney, M. Moor, A. Moreno, D. Morgan, B. Morris, C. Mossey, C. Motuk, E. Moura, C. A. and Mousseau, J. Mu, W. Mualem, L. Mueller, J. Muether, M. and Mufson, S. Muheim, F. Muir, A. Mulhearn, M. and Muramatsu, H. Murphy, S. Musser, J. Nachtman, J. Nagu, S. Nalbandyan, M. Nandakumar, R. Naples, D. Narita, S. and Navas-Nicolas, D. Nayak, N. Nebot-Guinot, M. Necib, L. and Negishi, K. Nelson, J. K. Nesbit, J. Nessi, M. and Newbold, D. Newcomer, M. Newhart, D. Nichol, R. Niner, E. Nishimura, K. Norman, A. Northrop, R. Novella, P. and Nowak, J. A. Oberling, M. Del Campo, A. Olivares Olivier, A. and Onel, Y. Onishchuk, Y. Ott, J. Pagani, L. Pakvasa, S. Palamara, O. Palestini, S. Paley, J. M. Pallavicini, M. Palomares, C. Pantic, E. Paolone, V Papadimitriou, V and Papaleo, R. Papanestis, A. Paramesvaran, S. Parke, S. and Parsa, Z. Parvu, M. Pascoli, S. Pasqualini, L. and Pasternak, J. Pater, J. Patrick, C. Patrizii, L. and Patterson, R. B. Patton, S. Patzak, T. Paudel, A. and Paulos, B. Paulucci, L. Pavlovic, Z. Pawloski, G. Payne, D. Pec, V Peeters, S. J. Penichot, Y. Pennacchio, E. and Penzo, A. Peres, O. L. Perry, J. Pershey, D. Pessina, G. and Petrillo, G. Petta, C. Petti, R. Piastra, F. and Pickering, L. Pietropaolo, F. Pillow, J. Plunkett, R. and Poling, R. Pons, X. Poonthottathil, N. Pordes, S. and Potekhin, M. Potenza, R. Potukuchi, V, B. Pozimski, J. and Pozzato, M. Prakash, S. Prakash, T. Prince, S. Prior, G. and Pugnere, D. Qi, K. Qian, X. Raaf, J. Raboanary, R. and Radeka, V Rademacker, J. Radics, B. Rafique, A. and Raguzin, E. Rai, M. Rajaoalisoa, M. Rakhno, I and Rakotondramanana, H. Rakotondravohitra, L. Ramachers, Y. and Rameika, R. Ramirez Delgado, M. Ramson, B. Rappoldi, A. and Raselli, G. Ratoff, P. Ravat, S. Razafinime, H. Real, J. and Rebel, B. Redondo, D. Reggiani-Guzzo, M. Rehak, T. and Reichenbacher, J. Reitzner, S. D. Renshaw, A. Rescia, S. and Resnati, F. Reynolds, A. Riccobene, G. Rice, L. C. and Rielage, K. Rigaut, Y. Rivera, D. Rochester, L. Roda, M. and Rodrigues, P. Alonso, M. Rodriguez Rondon, J. Rodriguez and Roeth, A. Rogers, H. Rosauro-Alcaraz, S. Rossella, M. and Rout, J. Roy, S. Rubbia, A. Rubbia, C. Russell, B. and Russell, J. Ruterbories, D. Saakyan, R. Sacerdoti, S. and Safford, T. Sahu, N. Sala, P. Samios, N. Sanchez, M. and Sanders, D. A. Sankey, D. Santana, S. Santos-Maldonado, M. and Saoulidou, N. Sapienza, P. Sarasty, C. Sarcevic, I and Savage, G. Savinov, V Scaramelli, A. Scarff, A. and Scarpelli, A. Schaffer, T. Schellman, H. Schlabach, P. and Schmitz, D. Scholberg, K. Schukraft, A. Segreto, E. and Sensenig, J. Seong, I Sergi, A. Sergiampietri, F. and Sgalaberna, D. Shaevitz, M. Shafaq, S. Shamma, M. and Sharma, H. R. Sharma, R. Shaw, T. Shepherd-Themistocleous, C. Shin, S. Shooltz, D. Shrock, R. Simard, L. Simos, N. Sinclair, J. Sinev, G. Singh, J. Singh, J. Singh, V Sipos, R. Sippach, F. Sirri, G. Sitraka, A. and Siyeon, K. Smargianaki, D. Smith, A. Smith, A. Smith, E. and Smith, P. Smolik, J. Smy, M. Snopok, P. Nunes, M. Soares Sobel, H. Soderberg, M. Solano Salinas, C. J. and Soldner-Rembold, S. Solomey, N. Solovov, V Sondheim, W. E. and Sorel, M. Soto-Oton, J. Sousa, A. Soustruznik, K. and Spagliardi, F. Spanu, M. Spitz, J. Spooner, N. J. and Spurgeon, K. Staley, R. Stancari, M. Stanco, L. Steiner, H. Stewart, J. Stillwell, B. Stock, J. Stocker, F. and Stokes, T. Strait, M. Strauss, T. Striganov, S. Stuart, A. Summers, D. Surdo, A. Susic, V Suter, L. Sutera, C. Svoboda, R. Szczerbinska, B. Szelc, A. Talaga, R. and Tanaka, H. Oregui, B. Tapia Tapper, A. Tariq, S. Tatar, E. Tayloe, R. Teklu, A. Tenti, M. Terao, K. Ternes, C. A. Terranova, F. Testera, G. Thea, A. Thompson, J. L. and Thorn, C. Timm, S. Tonazzo, A. Torti, M. Tortola, M. and Tortorici, F. Totani, D. Toups, M. Touramanis, C. and Trevor, J. Trzaska, W. H. Tsai, Y. T. Tsamalaidze, Z. and Tsang, K. Tsverava, N. Tufanli, S. Tull, C. Tyley, E. and Tzanov, M. Uchida, M. A. Urheim, J. Usher, T. and Vagins, M. Vahle, P. Valdiviesso, G. Valencia, E. and Vallari, Z. Valle, J. W. Vallecorsa, S. Van Berg, R. Van de Water, R. G. Forero, D. Vanegas Varanini, F. Vargas, D. and Varner, G. Vasel, J. Vasseur, G. Vaziri, K. Ventura, S. Verdugo, A. Vergani, S. Vermeulen, M. A. Verzocchi, M. de Souza, H. Vieira Vignoli, C. Vilela, C. Viren, B. and Vrba, T. Wachala, T. Waldron, V, A. Wallbank, M. and Wang, H. Wang, J. Wang, Y. Wang, Y. Warburton, K. and Warner, D. Wascko, M. Waters, D. Watson, A. Weatherly, P. Weber, A. Weber, M. Wei, H. Weinstein, A. Wenman, D. Wetstein, M. While, M. R. White, A. Whitehead, L. H. and Whittington, D. Wilking, M. J. Wilkinson, C. Williams, Z. Wilson, F. Wilson, R. J. Wolcott, J. Wongjirad, T. and Wood, K. Wood, L. Worcester, E. Worcester, M. Wret, C. Wu, W. Wu, W. Xiao, Y. Yang, G. Yang, T. and Yershov, N. Yonehara, K. Young, T. Yu, B. Yu, J. and Zalesak, J. Zambelli, L. Zamorano, B. Zani, A. Zazueta, L. Zeller, G. Zennamo, J. Zeug, K. Zhang, C. Zhao, M. Zhivun, E. Zhu, G. Zimmerman, E. D. Zito, M. and Zucchelli, S. Zuklin, J. Zutshi, V Zwaska, R. DUNE Collaboration
Published: 2020

15. Volume I. Introduction to DUNE

Author: Abi, B. Acciarri, R. Acero, M. A. Adamov, G. Adams, D. and Adinolfi, M. Ahmad, Z. Ahmed, J. Alion, T. Monsalve, S. Alonso Alt, C. Anderson, J. Andreopoulos, C. Andrews, M. Andrianala, F. Andringa, S. Ankowski, A. Antonova, M. and Antusch, S. Aranda-Fernandez, A. Ariga, A. Arnold, L. O. and Arroyave, M. A. Asaadi, J. Aurisano, A. Aushev, V. and Autiero, D. Azfar, F. Back, H. Back, J. J. Backhouse, C. and Baesso, P. Bayby, L. Bajou, R. Balasubramanian, S. and Baldi, P. Bambah, B. Barao, F. Barenhoim, G. Barker, G. and Barkhouse, W. Barnes, C. Barr, G. Monarca, J. Barranco and Barros, N. Barrow, J. L. Bashyal, A. Basque, V. Bay, F. Alba, J. Bazo Beacom, J. F. Bechetoille, E. Behera, B. Bellantoni, L. Bellettini, G. Bellini, V. and Beltramello, O. Belver, D. Benckos, N. Neves, F. Bento and Berger, J. Berkman, S. Bernardini, P. Berner, R. M. and Berns, H. Bertolucci, S. Betancourt, M. Bezawada, Y. and Bhattacharjee, M. Bhuyan, B. Biagi, S. Bian, J. and Biassoni, M. Bierv, K. Bilki, B. Bishai, M. Bitadze, A. and Blake, A. Siffert, B. Blanco Blaszczyk, F. Blazey, G. and Blucher, E. Boissevain, J. Bolognesi, S. Bolton, T. and Bonesini, M. Bongrand, M. Bonini, F. Booth, A. Booth, C. and Bordoni, S. Borkum, A. Boschi, T. Bostan, N. Bour, P. Boyd, S. Bovden, D. Bracinik, J. Braga, D. and Brailsford, D. Brandt, A. Bremer, J. Brew, C. Brianne, E. Brice, S. J. Brizzolari, C. Bromherg, C. Brooijmans, G. Brooke, J. Bross, A. Brunetti, G. Buchanan, N. and Budd, H. Caiulo, D. Calaftura, P. Calcutt, J. Calin, M. and Calvez, S. Calvo, E. Camilleri, L. Caminata, A. and Campanelli, M. Caratelli, D. Carini, G. Carlus, B. and Carniti, P. Terrazas, I. Caro Carranza, H. Castillo, A. and Castromonte, C. Cattadori, C. Cavalier, F. Cavanna, F. and Centro, S. Cerati, G. Cervelli, A. Cervera Villanueva, A. and Chalifour, M. Chang, C. Chardonnet, E. Chatterjee, A. and Chattopadhyay, S. Chaves, J. Chen, H. Chen, M. Chen, Y. Cherdack, D. Chi, C. Childress, S. Chiriacescu, A. and Cho, K. Choubey, S. Christensen, A. Christian, D. and Christodoulou, G. Church, E. Clarke, P. Coan, T. E. and Cocco, A. G. Coelho, J. Conley, E. Conrad, J. Convery, M. Corwin, L. Cotte, P. Cremaldi, L. Cremonesi, L. and Crespo-Anadon, J. I. Cristaldo, E. Cross, R. Cuesta, C. and Cui, Y. Cussans, D. Dahrowski, M. Da Motta, H. Da Silva Peres, L. David, Q. Davies, G. S. Davini, S. Dawson, J. and De, K. De Almeida, R. M. Debbins, P. De Bonis, I. and Decowski, M. De Gouvea, A. De Holanda, P. C. Astiz, I. L. De Icaza Deistin, A. De Jong, P. Delbart, A. Delepine, D. and Delgado, M. Dell'Acqua, A. De Lurgio, P. De Mello Neto, J. R. DeMuth, D. M. Dennis, S. Densham, C. Deptuch, G. and De Roeck, A. De Romeri, V. De Vries, J. Dharmapalan, R. and Dias, M. Diaz, F. Diaz, J. Di Domizio, S. Di Giulio, L. Ding, P. Di Noto, L. Distefano, C. Diurba, R. and Diwan, M. Djurcic, Z. Dokania, N. Dolinski, M. Domine, L. Douglas, D. Drielsma, F. Duchesneau, D. Duffy, K. and Dunne, P. Durkin, T. Duyang, H. Dvornikov, O. Dwyer, D. and Dyshkant, A. Eads, M. Edmunds, D. Eisch, J. Emery, S. Ereditato, A. Escobar, C. Escudero Sanchez, L. Evans, J. J. Ewart, E. Ezeribe, A. C. Fahey, K. Falcone, A. and Farnese, C. Farzan, Y. Felix, J. Fernandez-Martinez, E. and Menendez, P. Fernandez Ferraro, F. Fields, L. Filkins, A. and Filthaut, F. Fitzpatrick, R. S. Flanagan, W. Fleming, B. and Flight, R. Fowler, J. Fox, W. Franc, J. Francis, K. and Franco, D. Freeman, J. Freestone, J. Fried, J. and Friedland, A. Fuess, S. Furic, I. Furmanski, A. P. Gago, A. Gallagher, H. Gallego-Ros, A. Gallice, N. Galymov, V. and Gamberini, E. Gamble, T. Gandhi, R. Gandrajula, R. and Gao, S. Garcia-Gamez, D. Garcia-Peris, M. A. Gardiner, S. and Gastler, D. Ge, G. Gelli, B. Gendotti, A. Gent, S. and Ghorbani-Moghaddam, Z. Gibin, D. Gil-Botella, L. Girerd, C. Giri, A. Gnani, D. Gogota, O. Gold, M. and Gollapinni, S. Gollwitzer, K. Gomes, R. A. Bermeo, L. Gomez and Fajardo, L. S. Gomez Gonnella, F. Gonzalez-Cuevas, J. and Goodman, M. C. Goodwin, O. Goswami, S. Gotti, C. and Goudzovski, E. Grace, C. Graham, M. Gramellini, E. Gran, R. Granados, E. Grant, A. Grant, C. Gratieri, D. and Green, P. Green, S. Greenler, L. Greenwood, M. Greer, J. and Griffith, C. Groh, M. Grudzinski, J. Grzelak, K. Gu, W. Guarino, V. Guenette, R. Guglielmi, A. Guo, B. and Guthikonda, K. Gutierrez, R. Guzowski, P. Guzzo, M. M. and Gwon, S. Habig, A. Hackenburg, A. Hadavand, H. Haenni, R. Hahn, A. Haigh, J. Haiston, J. Hamernik, T. and Hamilton, P. Han, J. Harder, K. Harris, D. A. Hartnell, J. Hasegawa, T. Hatcher, R. Hazen, E. Heavey, A. and Heeger, K. M. Hennessy, K. Henry, S. Morquecho, Vi. Hernandez Herner, K. Hertel, L. Hesam, A. S. Hewes, J. and Pichardo, A. Higuera Hill, T. Hillier, S. J. Himmel, A. and Hoff, J. Hohl, C. Holin, A. Hoppe, E. Horton-Smith, G. A. Hostert, M. Hourlier, A. Howard, B. Howell, R. and Huang, J. Huang, J. Hugon, J. Iles, G. Iliescu, A. M. and Illingworth, R. Ioannisian, A. Itay, R. Izmaylov, A. and James, E. Jargowsky, B. Jediny, F. Jesus-Valls, C. Ji, X. Jiang, L. Jimenez, S. Jipa, A. Joglekar, A. and Johnson, C. Johnson, R. Jones, B. Jones, S. Jung, C. and Junk, T. Jwa, Y. Kabirnezhad, M. Kaboth, A. Kadenko, I. and Kamiya, F. Karagiorgi, G. Karcher, A. Karolak, M. and Karyotakis, Y. Kasai, S. Kasetti, S. P. Kashur, L. and Kazaryan, N. Kearns, E. Keener, P. Kelly, K. J. Kemp, E. and Ketchum, W. Kettell, S. Kliabibullin, M. Khotjantsev, A. and Khvedelidze, A. Kim, D. King, B. Kirby, B. Kirby, M. and Klein, J. Koehler, K. Koerner, L. W. Kohn, S. and Koller, P. P. Kordosky, M. Kosc, T. Kose, U. Kostelecky, V. Kothekar, K. Krennrich, F. Kreslo, I. Kudenko, Y. and Kudryavtsev, V. Kulagin, S. Kumar, J. Kumar, R. Kuruppu, C. Kus, V. Kutter, T. Lamhert, A. Lande, K. Lane, C. E. Lang, K. Langford, T. Lasorak, P. Last, D. and Lastoria, C. Laundrie, A. Lawrence, A. Lazanu, I. LaZur, R. Le, T. Learned, J. LeBrun, P. Miotto, G. Lehmann and Lehnert, R. de Oliveira, M. Leigui Leitner, M. Leyton, M. and Li, L. Li, S. Li, S. Li, T. Li, Y. Liao, H. and Lin, C. Lin, S. Lister, A. Littlejohn, B. R. Liu, J. and Lockwitz, S. Loew, T. Lokajicek, M. Lomidze, I. Long, K. and Loo, K. Lorca, D. Lord, T. LoSecco, J. Louis, W. C. and Luk, K. Luo, X. Lurkin, N. Lux, T. Luzio, V. P. and MacFarland, D. Machado, A. Machado, P. Macias, C. and Macier, J. Maddalena, A. Madigan, P. Magill, S. Mahn, K. and Maio, A. Maloney, J. A. Mandrioli, G. Maneira, J. C. and Manenti, L. Manly, S. Mann, A. Manolopoulos, K. Plata, M. Manrique Marchionni, A. Marciano, W. Marfatia, D. and Mariani, C. Maricic, J. Marinho, F. Marino, A. D. and Marshak, M. Marshall, C. Marshall, J. Marteau, J. and Martin-Alho, J. Martinez, N. Caicedo, D. A. Martinez and Martynenko, S. Mason, K. Masthaum, A. Masud, M. Matsuno, S. Matthews, J. Mauger, C. Mauri, N. Mavrokoridis, K. and Mazza, R. Mazzacane, A. Mazzucato, E. McCluskey, E. and McConkey, N. McFarland, K. S. McGrew, C. McNab, A. and Mefodiev, A. Mehta, P. Melas, P. Mellinato, V. Mena, O. and Mcnary, S. Mendez, H. Menegolli, A. Meng, G. and Messier, V. Metcalf, W. Mewes, M. Meyer, H. Miao, T. and Michna, G. Miedema, T. Migenda, J. Milincic, R. Miller, W. Mills, J. Milne, C. Mineev, O. Miranda, O. G. and Miryala, S. Mishra, C. Mishra, S. Mislivec, A. Mladenov, D. Mocioiu, I. Moffat, K. Moggi, N. Mohanta, R. and Mohayai, T. A. Mokhov, N. Molina, J. A. Bueno, L. Molina and Montanari, A. Montanari, C. Montanari, D. Montano Zetina, L. M. Moon, J. Mooney, M. Moor, A. Moreno, D. Morgan, B. Morris, C. Mossey, C. Motuk, E. Moura, C. A. and Mousseau, J. Mu, W. Mualem, L. Mueller, J. Muether, M. and Mufson, S. Muheim, F. Muir, A. Mulhearn, M. and Muramatsu, H. Murphy, S. Musser, J. Nachtman, J. Nagu, S. Nalbandyan, M. Nandakumar, R. Naples, D. Narita, S. and Navas-Nicolas, D. Nayak, N. Nebot-Guinot, M. Necib, L. and Negishi, K. Nelson, J. K. Nesbit, J. Nessi, M. and Newbold, D. Newcomer, M. Newhart, D. Nichol, R. Niner, E. Nishimura, K. Norman, A. Northrop, R. Novella, P. and Nowak, J. A. Oberling, M. Del Campo, A. Olivares Olivier, A. and Onel, Y. Onishchuk, Y. Ott, J. Pagani, L. Pakvasa, S. Palamara, O. Palestini, S. Paley, J. M. Pallavicini, M. Palomares, C. Pantic, E. Paolone, V. Papadimitriou, V. Papaleo, R. Papanestis, A. Paramesvaran, S. Parke, S. and Parsa, Z. Parvu, M. Pascoli, S. Pasqualini, L. and Pasternak, J. Pater, J. Patrick, C. Patrizii, L. and Patterson, R. B. Patton, S. Patzak, T. Paudel, A. and Paulos, B. Paulucci, L. Pavlovic, Z. Pawloski, G. Payne, D. Pec, V. Peeters, S. J. Penichot, Y. Pennacchio, E. and Penzo, A. Peres, O. L. Perry, J. Pershey, D. and Pessina, G. Petrillo, G. Petta, C. Petti, R. Piastra, F. and Pickering, L. Pietropaolo, F. Pillows, J. Plunkett, R. and Poling, R. Pons, X. Poonthottathil, N. Pordes, S. and Potekhin, M. Potenza, R. Potukuchi, B. V. Pozimski, J. and Pozzato, M. Prakash, S. Prakash, T. Prince, S. Prior, G. and Pugnere, D. Qi, K. Qian, X. Raaf, J. Raboanary, R. and Radeka, V. Rademacker, J. Radics, B. Rafique, A. and Raguzin, E. Rai, M. Rajarialisoa, M. Rakhno, I. and Rakotondramanana, H. Rakotondravollitra, L. Ramachers, Y. and Rameika, R. Delgado, Vi. Ramirez Ramson, B. Rappoldi, A. and Raselli, G. Ratoff, P. Ravat, S. Razafinime, H. Real, J. and Rebel, B. Redondo, D. Reggiani-Guzzo, M. Rehak, T. and Reichenbacher, J. Reitzner, S. D. Renshaw, A. Rescia, S. and Resnati, F. Reynolds, A. Riccobene, G. Rice, L. C. and Rielage, K. Rigaut, Y. Rivera, D. Rochester, L. Roda, M. and Rodrigues, P. Alonso, M. Rodriguez Rondon, J. Rodriguez and Roeth, A. Rogers, H. Rosauro-Alcaraz, S. Rossella, M. and Rout, J. Roy, S. Rubbia, A. Rubbia, C. Russell, B. and Russell, J. Ruterbories, D. Saakyan, R. Sacerdoti, S. and Safford, T. Sahu, N. Sala, P. Samios, N. Sanchez, M. and Sanders, D. A. Sankey, D. Santana, S. Santos-Maldonado, M. and Saoulidou, N. Sapienza, P. Sarasty, C. Sarcevic, I. and Savage, G. Savinov, V. Scaramelli, A. Scarff, A. and Scarpelli, A. Schaffer, T. Schellman, H. Schlabach, P. and Schmitz, D. Scholberg, K. Schukraft, A. Segreto, E. and Sensenig, J. Seong, I. Sergi, A. Sergiampietri, F. and Sgalaberna, D. Shaevitz, M. Shafaq, S. Shamma, M. and Sharma, H. R. Sharma, R. Shaw, T. Shepherd-Themistocleous, C. Shin, S. Shooltz, D. Shrock, R. Simard, L. Simos, N. Sinclair, J. Sinev, G. Singh, J. Singh, J. Singh, V. Sipos, R. Sippach, F. Sirri, G. Sitraka, A. and Siyeon, K. Smargianaki, D. Smith, A. Smith, A. Smith, E. and Smith, P. Smolik, J. Smy, M. Snopok, P. Nunes, M. Soares Sobel, H. Soderberg, M. Salinas, C. J. Solano and Soldner-Remhold, S. Solomey, N. Solovov, V. Sondheim, W. E. and Sorel, M. Soto-Oton, J. Sousa, A. Soustruznik, K. and Spagliardi, F. Spanu, M. Spitz, J. Spooner, N. J. and Spurgeon, K. Staley, R. Stancari, M. Stanco, L. Steiner, H. Stewart, J. Stillwell, B. Stock, J. Stocker, F. and Stokes, T. Strait, M. Strauss, T. Strianov, S. Stuart, A. Summers, D. Surdo, A. Susic, V. Suter, L. Sutera, C. Svoboda, R. Szczerbinska, B. Szelc, A. Talaga, R. and Tanaka, H. Oregui, B. Tapia Tapper, A. Tariq, S. Tatar, E. Tayloe, R. Teklu, A. Tenti, M. Terao, K. Ternes, C. A. Terranova, F. Testera, G. Thea, A. Thompson, J. L. and Thorn, C. Timm, S. Tonazzo, A. Torti, M. Tortola, M. and Tortorici, F. Totani, D. Toups, M. Touramanis, C. and Trevor, J. Trzaska, Wh. Tsai, Yt. Tsamalaidze, Z. Tsang, K. Tsverava, N. Tufanli, S. Tull, C. Tyley, E. and Tzanov, Vi. Uchida, Vi. A. Urheim, J. Usher, T. Vagins, Vi. Vahle, P. Valdiviesso, G. Valencia, E. Vallari, Z. and Valle, J. W. Vallecorsa, S. Van Berg, R. Van de Water, R. G. Vanegas Forero, D. Varanini, F. Vargas, D. Varner, G. Vasel, J. Vasseur, G. Vaziri, K. Ventura, S. and Verdugo, A. Vergani, S. Vermeulen, M. A. Verzocchi, M. and Vieira de Souza, H. Vignoli, C. Vilela, C. Viren, B. and Vrba, T. Wachala, T. Waldron, A. V. Wallbank, M. Wang, H. Wang, J. Wang, Y. Wang, Y. Warburton, K. Warner, D. Wascko, M. Waters, D. Watson, A. Weatherly, P. and Weber, A. Weber, M. Wei, H. Weinstein, A. Wenman, D. and Wetstein, M. While, M. R. White, A. Whitehead, L. H. and Whittington, D. Wilking, M. J. Wilkinson, C. Williams, Z. and Wilson, F. Wilson, R. J. Wolcott, J. Wongjirad, T. and Wood, K. Wood, L. Worcester, E. Worcester, M. Wret, C. and Wu, W. Wu, W. Xiao, Y. Yang, G. Yang, T. and Yershov, N. Yonehara, K. Young, T. Yu, B. Yu, J. and Zalesak, J. Zambelli, L. Zamorano, B. Zani, A. Zazueta, L. Zeller, G. Zennamo, J. Zeug, K. Zhang, C. Zhao, M. Zhivun, E. Zhu, G. Zimmerman, E. D. Zito, M. and Zuccilelli, S. Zuklin, J. Zuishi, V. Zwaska, R. DUNE Collaboration
Published: 2020

16. Long-baseline neutrino oscillation physics potential of the DUNE experiment: DUNE Collaboration

Author: Abi, B. Acciarri, R. Acero, M.A. Adamov, G. Adams, D. Adinolfi, M. Ahmad, Z. Ahmed, J. Alion, T. Monsalve, S.A. Alt, C. Anderson, J. Andreopoulos, C. Andrews, M.P. Andrianala, F. Andringa, S. Ankowski, A. Antonova, M. Antusch, S. Aranda-Fernandez, A. Ariga, A. Arnold, L.O. Arroyave, M.A. Asaadi, J. Aurisano, A. Aushev, V. Autiero, D. Azfar, F. Back, H. Back, J.J. Backhouse, C. Baesso, P. Bagby, L. Bajou, R. Balasubramanian, S. Baldi, P. Bambah, B. Barao, F. Barenboim, G. Barker, G.J. Barkhouse, W. Barnes, C. Barr, G. Monarca, J.B. Barros, N. Barrow, J.L. Bashyal, A. Basque, V. Bay, F. Alba, J.L.B. Beacom, J.F. Bechetoille, E. Behera, B. Bellantoni, L. Bellettini, G. Bellini, V. Beltramello, O. Belver, D. Benekos, N. Neves, F.B. Berger, J. Berkman, S. Bernardini, P. Berner, R.M. Berns, H. Bertolucci, S. Betancourt, M. Bezawada, Y. Bhattacharjee, M. Bhuyan, B. Biagi, S. Bian, J. Biassoni, M. Biery, K. Bilki, B. Bishai, M. Bitadze, A. Blake, A. Siffert, B.B. Blaszczyk, F.D.M. Blazey, G.C. Blucher, E. Boissevain, J. Bolognesi, S. Bolton, T. Bonesini, M. Bongrand, M. Bonini, F. Booth, A. Booth, C. Bordoni, S. Borkum, A. Boschi, T. Bostan, N. Bour, P. Boyd, S.B. Boyden, D. Bracinik, J. Braga, D. Brailsford, D. Brandt, A. Bremer, J. Brew, C. Brianne, E. Brice, S.J. Brizzolari, C. Bromberg, C. Brooijmans, G. Brooke, J. Bross, A. Brunetti, G. Buchanan, N. Budd, H. Caiulo, D. Calafiura, P. Calcutt, J. Calin, M. Calvez, S. Calvo, E. Camilleri, L. Caminata, A. Campanelli, M. Caratelli, D. Carini, G. Carlus, B. Carniti, P. Terrazas, I.C. Carranza, H. Castillo, A. Castromonte, C. Cattadori, C. Cavalier, F. Cavanna, F. Centro, S. Cerati, G. Cervelli, A. Villanueva, A.C. Chalifour, M. Chang, C. Chardonnet, E. Chatterjee, A. Chattopadhyay, S. Chaves, J. Chen, H. Chen, M. Chen, Y. Cherdack, D. Chi, C. Childress, S. Chiriacescu, A. Cho, K. Choubey, S. Christensen, A. Christian, D. Christodoulou, G. Church, E. Clarke, P. Coan, T.E. Cocco, A.G. Coelho, J.A.B. Conley, E. Conrad, J.M. Convery, M. Corwin, L. Cotte, P. Cremaldi, L. Cremonesi, L. Crespo-Anadón, J.I. Cristaldo, E. Cross, R. Cuesta, C. Cui, Y. Cussans, D. Dabrowski, M. Motta, H. Da Silva Peres, L. David, C. David, Q. Davies, G.S. Davini, S. Dawson, J. De, K. De Almeida, R.M. Debbins, P. De Bonis, I. Decowski, M.P. de Gouvêa, A. De Holanda, P.C. De Icaza Astiz, I.L. Deisting, A. De Jong, P. Delbart, A. Delepine, D. Delgado, M. Dell’Acqua, A. De Lurgio, P. de Mello Neto, J.R.T. DeMuth, D.M. Dennis, S. Densham, C. Deptuch, G. De Roeck, A. De Romeri, V. De Vries, J.J. Dharmapalan, R. Dias, M. Diaz, F. Díaz, J.S. Domizio, S.D. Giulio, L.D. Ding, P. Noto, L.D. Distefano, C. Diurba, R. Diwan, M. Djurcic, Z. Dokania, N. Dolinski, M.J. Domine, L. Douglas, D. Drielsma, F. Duchesneau, D. Duffy, K. Dunne, P. Durkin, T. Duyang, H. Dvornikov, O. Dwyer, D.A. Dyshkant, A.S. Eads, M. Edmunds, D. Eisch, J. Emery, S. Ereditato, A. Escobar, C.O. Sanchez, L.E. Evans, J.J. Ewart, E. Ezeribe, A.C. Fahey, K. Falcone, A. Farnese, C. Farzan, Y. Felix, J. Fernandez-Martinez, E. Menendez, P.F. Ferraro, F. Fields, L. Filkins, A. Filthaut, F. Fitzpatrick, R.S. Flanagan, W. Fleming, B. Flight, R. Fowler, J. Fox, W. Franc, J. Francis, K. Franco, D. Freeman, J. Freestone, J. Fried, J. Friedland, A. Fuess, S. Furic, I. Furmanski, A.P. Gago, A. Gallagher, H. Gallego-Ros, A. Gallice, N. Galymov, V. Gamberini, E. Gamble, T. Gandhi, R. Gandrajula, R. Gao, S. Garcia-Gamez, D. García-Peris, M.Á. Gardiner, S. Gastler, D. Ge, G. Gelli, B. Gendotti, A. Gent, S. Ghorbani-Moghaddam, Z. Gibin, D. Gil-Botella, I. Girerd, C. Giri, A.K. Gnani, D. Gogota, O. Gold, M. Gollapinni, S. Gollwitzer, K. Gomes, R.A. Bermeo, L.V.G. Fajardo, L.S.G. Gonnella, F. Gonzalez-Cuevas, J.A. Goodman, M.C. Goodwin, O. Goswami, S. Gotti, C. Goudzovski, E. Grace, C. Graham, M. Gramellini, E. Gran, R. Granados, E. Grant, A. Grant, C. Gratieri, D. Green, P. Green, S. Greenler, L. Greenwood, M. Greer, J. Griffith, W.C. Groh, M. Grudzinski, J. Grzelak, K. Gu, W. Guarino, V. Guenette, R. Guglielmi, A. Guo, B. Guthikonda, K.K. Gutierrez, R. Guzowski, P. Guzzo, M.M. Gwon, S. Habig, A. Hackenburg, A. Hadavand, H. Haenni, R. Hahn, A. Haigh, J. Haiston, J. Hamernik, T. Hamilton, P. Han, J. Harder, K. Harris, D.A. Hartnell, J. Hasegawa, T. Hatcher, R. Hazen, E. Heavey, A. Heeger, K.M. Heise, J. Hennessy, K. Henry, S. Morquecho, M.A.H. Herner, K. Hertel, L. Hesam, A.S. Hewes, J. Higuera, A. Hill, T. Hillier, S.J. Himmel, A. Hoff, J. Hohl, C. Holin, A. Hoppe, E. Horton-Smith, G.A. Hostert, M. Hourlier, A. Howard, B. Howell, R. Huang, J. Huang, J. Hugon, J. Iles, G. Ilic, N. Iliescu, A.M. Illingworth, R. Ioannisian, A. Itay, R. Izmaylov, A. James, E. Jargowsky, B. Jediny, F. Jesùs-Valls, C. Ji, X. Jiang, L. Jiménez, S. Jipa, A. Joglekar, A. Johnson, C. Johnson, R. Jones, B. Jones, S. Jung, C.K. Junk, T. Jwa, Y. Kabirnezhad, M. Kaboth, A. Kadenko, I. Kamiya, F. Karagiorgi, G. Karcher, A. Karolak, M. Karyotakis, Y. Kasai, S. Kasetti, S.P. Kashur, L. Kazaryan, N. Kearns, E. Keener, P. Kelly, K.J. Kemp, E. Ketchum, W. Kettell, S.H. Khabibullin, M. Khotjantsev, A. Khvedelidze, A. Kim, D. King, B. Kirby, B. Kirby, M. Klein, J. Koehler, K. Koerner, L.W. Kohn, S. Koller, P.P. Kordosky, M. Kosc, T. Kose, U. Kostelecký, V.A. Kothekar, K. Krennrich, F. Kreslo, I. Kudenko, Y. Kudryavtsev, V.A. Kulagin, S. Kumar, J. Kumar, R. Kuruppu, C. Kus, V. Kutter, T. Lambert, A. Lande, K. Lane, C.E. Lang, K. Langford, T. Lasorak, P. Last, D. Lastoria, C. Laundrie, A. Lawrence, A. Lazanu, I. LaZur, R. Le, T. Learned, J. LeBrun, P. Miotto, G.L. Lehnert, R. de Oliveira, M.A.L. Leitner, M. Leyton, M. Li, L. Li, S. Li, S.W. Li, T. Li, Y. Liao, H. Lin, C.S. Lin, S. Lister, A. Littlejohn, B.R. Liu, J. Lockwitz, S. Loew, T. Lokajicek, M. Lomidze, I. Long, K. Loo, K. Lorca, D. Lord, T. LoSecco, J.M. Louis, W.C. Luk, K.B. Luo, X. Lurkin, N. Lux, T. Luzio, V.P. MacFarland, D. Machado, A.A. Machado, P. Macias, C.T. Macier, J.R. Maddalena, A. Madigan, P. Magill, S. Mahn, K. Maio, A. Maloney, J.A. Mandrioli, G. Maneira, J. Manenti, L. Manly, S. Mann, A. Manolopoulos, K. Plata, M.M. Marchionni, A. Marciano, W. Marfatia, D. Mariani, C. Maricic, J. Marinho, F. Marino, A.D. Marshak, M. Marshall, C. Marshall, J. Marteau, J. Martin-Albo, J. Martinez, N. Caicedo, D.A.M. Martynenko, S. Mason, K. Mastbaum, A. Masud, M. Matsuno, S. Matthews, J. Mauger, C. Mauri, N. Mavrokoridis, K. Mazza, R. Mazzacane, A. Mazzucato, E. McCluskey, E. McConkey, N. McFarland, K.S. McGrew, C. McNab, A. Mefodiev, A. Mehta, P. Melas, P. Mellinato, M. Mena, O. Menary, S. Mendez, H. Menegolli, A. Meng, G. Messier, M.D. Metcalf, W. Mewes, M. Meyer, H. Miao, T. Michna, G. Miedema, T. Migenda, J. Milincic, R. Miller, W. Mills, J. Milne, C. Mineev, O. Miranda, O.G. Miryala, S. Mishra, C.S. Mishra, S.R. Mislivec, A. Mladenov, D. Mocioiu, I. Moffat, K. Moggi, N. Mohanta, R. Mohayai, T.A. Mokhov, N. Molina, J. Bueno, L.M. Montanari, A. Montanari, C. Montanari, D. Zetina, L.M.M. Moon, J. Mooney, M. Moor, A. Moreno, D. Morgan, B. Morris, C. Mossey, C. Motuk, E. Moura, C.A. Mousseau, J. Mu, W. Mualem, L. Mueller, J. Muether, M. Mufson, S. Muheim, F. Muir, A. Mulhearn, M. Muramatsu, H. Murphy, S. Musser, J. Nachtman, J. Nagu, S. Nalbandyan, M. Nandakumar, R. Naples, D. Narita, S. Navas-Nicolás, D. Nayak, N. Nebot-Guinot, M. Necib, L. Negishi, K. Nelson, J.K. Nesbit, J. Nessi, M. Newbold, D. Newcomer, M. Newhart, D. Nichol, R. Niner, E. Nishimura, K. Norman, A. Norrick, A. Northrop, R. Novella, P. Nowak, J.A. Oberling, M. Campo, A.O.D. Olivier, A. Onel, Y. Onishchuk, Y. Ott, J. Pagani, L. Pakvasa, S. Palamara, O. Palestini, S. Paley, J.M. Pallavicini, M. Palomares, C. Pantic, E. Paolone, V. Papadimitriou, V. Papaleo, R. Papanestis, A. Paramesvaran, S. Parke, S. Parsa, Z. Parvu, M. Pascoli, S. Pasqualini, L. Pasternak, J. Pater, J. Patrick, C. Patrizii, L. Patterson, R.B. Patton, S.J. Patzak, T. Paudel, A. Paulos, B. Paulucci, L. Pavlovic, Z. Pawloski, G. Payne, D. Pec, V. Peeters, S.J.M. Penichot, Y. Pennacchio, E. Penzo, A. Peres, O.L.G. Perry, J. Pershey, D. Pessina, G. Petrillo, G. Petta, C. Petti, R. Piastra, F. Pickering, L. Pietropaolo, F. Pillow, J. Pinzino, J. Plunkett, R. Poling, R. Pons, X. Poonthottathil, N. Pordes, S. Potekhin, M. Potenza, R. Potukuchi, B.V.K.S. Pozimski, J. Pozzato, M. Prakash, S. Prakash, T. Prince, S. Prior, G. Pugnere, D. Qi, K. Qian, X. Raaf, J.L. Raboanary, R. Radeka, V. Rademacker, J. Radics, B. Rafique, A. Raguzin, E. Rai, M. Rajaoalisoa, M. Rakhno, I. Rakotondramanana, H.T. Rakotondravohitra, L. Ramachers, Y.A. Rameika, R. Delgado, M.A.R. Ramson, B. Rappoldi, A. Raselli, G. Ratoff, P. Ravat, S. Razafinime, H. Real, J.S. Rebel, B. Redondo, D. Reggiani-Guzzo, M. Rehak, T. Reichenbacher, J. Reitzner, S.D. Renshaw, A. Rescia, S. Resnati, F. Reynolds, A. Riccobene, G. Rice, L.C.J. Rielage, K. Rigaut, Y. Rivera, D. Rochester, L. Roda, M. Rodrigues, P. Alonso, M.J.R. Rondon, J.R. Roeth, A.J. Rogers, H. Rosauro-Alcaraz, S. Rossella, M. Rout, J. Roy, S. Rubbia, A. Rubbia, C. Russell, B. Russell, J. Ruterbories, D. Saakyan, R. Sacerdoti, S. Safford, T. Sahu, N. Sala, P. Samios, N. Sanchez, M.C. Sanders, D.A. Sankey, D. Santana, S. Santos-Maldonado, M. Saoulidou, N. Sapienza, P. Sarasty, C. Sarcevic, I. Savage, G. Savinov, V. Scaramelli, A. Scarff, A. Scarpelli, A. Schaffer, T. Schellman, H. Schlabach, P. Schmitz, D. Scholberg, K. Schukraft, A. Segreto, E. Sensenig, J. Seong, I. Sergi, A. Sergiampietri, F. Sgalaberna, D. Shaevitz, M.H. Shafaq, S. Shamma, M. Sharma, H.R. Sharma, R. Shaw, T. Shepherd-Themistocleous, C. Shin, S. Shooltz, D. Shrock, R. Simard, L. Simos, N. Sinclair, J. Sinev, G. Singh, J. Singh, J. Singh, V. Sipos, R. Sippach, F.W. Sirri, G. Sitraka, A. Siyeon, K. Smargianaki, D. Smith, A. Smith, A. Smith, E. Smith, P. Smolik, J. Smy, M. Snopok, P. Nunes, M.S. Sobel, H. Soderberg, M. Salinas, C.J.S. Söldner-Rembold, S. Solomey, N. Solovov, V. Sondheim, W.E. Sorel, M. Soto-Oton, J. Sousa, A. Soustruznik, K. Spagliardi, F. Spanu, M. Spitz, J. Spooner, N.J.C. Spurgeon, K. Staley, R. Stancari, M. Stanco, L. Steiner, H.M. Stewart, J. Stillwell, B. Stock, J. Stocker, F. Stokes, T. Strait, M. Strauss, T. Striganov, S. Stuart, A. Summers, D. Surdo, A. Susic, V. Suter, L. Sutera, C.M. Svoboda, R. Szczerbinska, B. Szelc, A.M. Talaga, R. Tanaka, H.A. Oregui, B.T. Tapper, A. Tariq, S. Tatar, E. Tayloe, R. Teklu, A.M. Tenti, M. Terao, K. Ternes, C.A. Terranova, F. Testera, G. Thea, A. Thompson, J.L. Thorn, C. Timm, S.C. Tonazzo, A. Torti, M. Tortola, M. Tortorici, F. Totani, D. Toups, M. Touramanis, C. Trevor, J. Trzaska, W.H. Tsai, Y.T. Tsamalaidze, Z. Tsang, K.V. Tsverava, N. Tufanli, S. Tull, C. Tyley, E. Tzanov, M. Uchida, M.A. Urheim, J. Usher, T. Vagins, M.R. Vahle, P. Valdiviesso, G.A. Valencia, E. Vallari, Z. Valle, J.W.F. Vallecorsa, S. Van Berg, R. Van de Water, R.G. Forero, D.V. Varanini, F. Vargas, D. Varner, G. Vasel, J. Vasseur, G. Vaziri, K. Ventura, S. Verdugo, A. Vergani, S. Vermeulen, M.A. Verzocchi, M. de Souza, H.V. Vignoli, C. Vilela, C. Viren, B. Vrba, T. Wachala, T. Waldron, A.V. Wallbank, M. Wang, H. Wang, J. Wang, Y. Wang, Y. Warburton, K. Warner, D. Wascko, M. Waters, D. Watson, A. Weatherly, P. Weber, A. Weber, M. Wei, H. Weinstein, A. Wenman, D. Wetstein, M. While, M.R. White, A. Whitehead, L.H. Whittington, D. Wilking, M.J. Wilkinson, C. Williams, Z. Wilson, F. Wilson, R.J. Wolcott, J. Wongjirad, T. Wood, K. Wood, L. Worcester, E. Worcester, M. Wret, C. Wu, W. Wu, W. Xiao, Y. Yang, G. Yang, T. Yershov, N. Yonehara, K. Young, T. Yu, B. Yu, J. Zaki, R. Zalesak, J. Zambelli, L. Zamorano, B. Zani, A. Zazueta, L. Zeller, G.P. Zennamo, J. Zeug, K. Zhang, C. Zhao, M. Zhivun, E. Zhu, G. Zimmerman, E.D. Zito, M. Zucchelli, S. Zuklin, J. Zutshi, V. Zwaska, R.
Subjects: Physics::Instrumentation and Detectors, High Energy Physics::Phenomenology, High Energy Physics::Experiment
Abstract: The sensitivity of the Deep Underground Neutrino Experiment (DUNE) to neutrino oscillation is determined, based on a full simulation, reconstruction, and event selection of the far detector and a full simulation and parameterized analysis of the near detector. Detailed uncertainties due to the flux prediction, neutrino interaction model, and detector effects are included. DUNE will resolve the neutrino mass ordering to a precision of 5σ, for all δCP values, after 2 years of running with the nominal detector design and beam configuration. It has the potential to observe charge-parity violation in the neutrino sector to a precision of 3σ (5σ) after an exposure of 5 (10) years, for 50% of all δCP values. It will also make precise measurements of other parameters governing long-baseline neutrino oscillation, and after an exposure of 15 years will achieve a similar sensitivity to sin 22 θ13 to current reactor experiments. © 2020, The Author(s).
Published: 2020

17. Honey against radiation-induced oral mucositis in head and neck cancer patients. An umbrella review of systematic reviews and meta-analyses of the literature

Author: Gkantaifi, A. Alongi, F. Vardas, E. Cuccia, F. Hajiioannou, J. Kyrodimos, E. Christopoulos, C. Mauri, D. Charalampakis, N. Trogkanis, N. Tsoukalas, N. Iliadis, G. Tolia, M.
Subjects: food and beverages
Abstract: Backround: Oral mucositis (OM) consists of a major side effect of radiotherapy (RT) in head and neck (H-N) cancer patients and natural honey is gaining more and more scientific interest due to its beneficial effects in tissue repair. Objective: The aim of this review is to better clarify the preventive/therapeutic role of honey in the management of OM in patients with H-N cancer undergoing RT with or without chemotherapy (C-T). Methods: We used the PubMed database to retrieve journal articles and the inclusion criteria were only reviews and meta-analyses that illustrated the effective use of honey for either the prevention or treatment of OM in H-N cancer patients receiving either RT alone or in combination with CT. Results: Our search resulted in 92 citations, of which 12 eventually fulfilled the inclusion criteria of our study. Decreased incidence and severity of OM, extended time of occurrence of mucositis, less weight loss and less treatment interruptions were occasionally documented with conventional honey use in the included reviews and meta-analyses. In contrast to conventional honey, manuka honey proved to be weak in improving OM management in the small number of included reviews in our search. Conclusion: Conventional honey might constitute a highly promising natural product against OM attracting much scientific interest due to its easy accessibility and low financial cost. Hence, the lack of studies with high evidence requires further advanced research to enhance the existing knowledge about the potential value of honey in radiation-induced OM in H-N cancer patients. © 2020 Bentham Science Publishers.
Published: 2020

18. Neutrino interaction classification with a convolutional neural network in the DUNE far detector

Author: Abi, B. Acciarri, R. Acero, M. A. Adamov, G. Adams, D. and Adinolfi, M. Ahmad, Z. Ahmed, J. Alion, T. Monsalve, S. Alonso Alt, C. Anderson, J. Andreopoulos, C. Andrews, M. P. Andrianala, F. Andringa, S. Ankowski, A. Antonova, M. Antusch, S. Aranda-Fernandez, A. Ariga, A. Arnold, L. O. Arroyave, M. A. Asaadi, J. Aurisano, A. Aushev, V. and Autiero, D. Azfar, F. Back, H. Back, J. J. and Backhouse, C. Baesso, P. Bagby, L. Bajou, R. and Balasubramanian, S. Baldi, P. Bambah, B. Barao, F. and Barenboim, G. Barker, G. J. Barkhouse, W. Barnes, C. and Barr, G. Monarca, J. Barranco Barros, N. Barrow, J. L. and Bashyal, A. Basque, V. Bay, F. Alba, J. L. Bazo Beacom, J. F. Bechetoille, E. Behera, B. Bellantoni, L. and Bellettini, G. Bellini, V. Beltramello, O. Belver, D. and Benekos, N. Bento Neves, F. Berger, J. Berkman, S. and Bernardini, P. Berner, R. M. Berns, H. Bertolucci, S. and Betancourt, M. Bezawada, Y. Bhattacharjee, M. Bhuyan, B. and Biagi, S. Bian, J. Biassoni, M. Biery, K. Bilki, B. and Bishai, M. Bitadze, A. Blake, A. Blanco Siffert, B. and Blaszczyk, F. D. M. Blazey, G. C. Blucher, E. Boissevain, J. and Bolognesi, S. Bolton, T. Bonesini, M. Bongrand, M. and Bonini, F. Booth, A. Booth, C. Bordoni, S. Borkum, A. and Boschi, T. Bostan, N. Bour, P. Boyd, S. B. Boyden, D. Bracinik, J. Braga, D. Brailsford, D. Brandt, A. and Bremer, J. Brew, C. Brianne, E. Brice, S. J. Brizzolari, C. Bromberg, C. Brooijmans, G. Brooke, J. Bross, A. and Brunetti, G. Buchanan, N. Budd, H. Caiulo, D. Calafiura, P. Calcutt, J. Calin, M. Calvez, S. Calvo, E. and Camilleri, L. Caminata, A. Campanelli, M. Caratelli, D. and Carini, G. Carlus, B. Carniti, P. Terrazas, I. Caro and Carranza, H. Castillo, A. Castromonte, C. Cattadori, C. and Cavalier, F. Cavanna, F. Centro, S. Cerati, G. Cervelli, A. Cervera Villanueva, A. Chalifour, M. Chang, C. and Chardonnet, E. Chatterjee, A. Chattopadhyay, S. Chaves, J. and Chen, H. Chen, M. Chen, Y. Cherdack, D. Chi, C. and Childress, S. Chiriacescu, A. Cho, K. Choubey, S. and Christensen, A. Christian, D. Christodoulou, G. Church, E. and Clarke, P. Coan, T. E. Cocco, A. G. Coelho, J. A. B. and Conley, E. Conrad, J. M. Convery, M. Corwin, L. Cotte, P. Cremaldi, L. Cremonesi, L. Crespo-Anadon, J. I. and Cristaldo, E. Cross, R. Cuesta, C. Cui, Y. Cussans, D. and Dabrowski, M. da Motta, H. Peres, L. Da Silva David, C. and David, Q. Davies, G. S. Davini, S. Dawson, J. De, K. and De Almeida, R. M. Debbins, P. De Bonis, I. Decowski, M. P. de Gouvea, A. De Holanda, P. C. Astiz, I. L. De Icaza and Deisting, A. De Jong, P. Delbart, A. Delepine, D. and Delgado, M. Dell'Acqua, A. De Lurgio, P. Neto, J. R. T. de Mello DeMuth, D. M. Dennis, S. Densham, C. Deptuch, G. and De Roeck, A. De Romeri, V. De Vries, J. J. Dharmapalan, R. Dias, M. Diaz, F. Diaz, J. S. Di Domizio, S. Di Giulio, L. Ding, P. Di Noto, L. Distefano, C. Diurba, R. and Diwan, M. Djurcic, Z. Dokania, N. Dolinski, M. J. and Domine, L. Douglas, D. Drielsma, F. Duchesneau, D. and Duffy, K. Dunne, P. Durkin, T. Duyang, H. Dvornikov, O. and Dwyer, D. A. Dyshkant, A. S. Eads, M. Edmunds, D. and Eisch, J. Emery, S. Ereditato, A. Escobar, C. O. and Sanchez, L. Escudero Evans, J. J. Ewart, E. Ezeribe, A. C. and Fahey, K. Falcone, A. Farnese, C. Farzan, Y. Felix, J. Fernandez-Martinez, E. Menendez, P. Fernandez Ferraro, F. and Fields, L. Filkins, A. Filthaut, F. Fitzpatrick, R. S. and Flanagan, W. Fleming, B. Flight, R. Fowler, J. Fox, W. Franc, J. Francis, K. Franco, D. Freeman, J. and Freestone, J. Fried, J. Friedland, A. Fuess, S. Furic, I. Furmanski, A. P. Gago, A. Gallagher, H. Gallego-Ros, A. Gallice, N. Galymov, V. Gamberini, E. Gamble, T. and Gandhi, R. Gandrajula, R. Gao, S. Garcia-Carballeira, F. and Garcia-Gamez, D. Garcia-Peris, M. A. Gardiner, S. Gastler, D. Ge, G. Gelli, B. Gendotti, A. Gent, S. and Ghorbani-Moghaddam, Z. Gibin, D. Gil-Botella, I. Girerd, C. and Giri, A. K. Gnani, D. Gogota, O. Gold, M. and Gollapinni, S. Gollwitzer, K. Gomes, R. A. Bermeo, L. V. Gomez Fajardo, L. S. Gomez Gonnella, F. Gonzalez-Cuevas, J. A. Goodman, M. C. Goodwin, O. Goswami, S. Gotti, C. and Goudzovski, E. Grace, C. Graham, M. Gramellini, E. Gran, R. Granados, E. Grant, A. Grant, C. Gratieri, D. and Green, P. Green, S. Greenler, L. Greenwood, M. Greer, J. and Griffith, W. C. Groh, M. Grudzinski, J. Grzelak, K. and Gu, W. Guarino, V. Guenette, R. Guglielmi, A. Guo, B. and Guthikonda, K. K. Gutierrez, R. Guzowski, P. Guzzo, M. M. Gwon, S. Habig, A. Hackenburg, A. Hadavand, H. and Haenni, R. Hahn, A. Haigh, J. Haiston, J. Hamernik, T. and Hamilton, P. Han, J. Harder, K. Harris, D. A. and Hartnell, J. Hasegawa, T. Hatcher, R. Hazen, E. Heavey, A. Heeger, K. M. Heise, J. Hennessy, K. Henry, S. and Morquecho, M. A. Hernandez Herner, K. Hertel, L. Hesam, A. S. Hewes, J. Higuera, A. Hill, T. Hillier, S. J. and Himmel, A. Hoff, J. Hohl, C. Holin, A. Hoppe, E. and Horton-Smith, G. A. Hostert, M. Hourlier, A. Howard, B. and Howell, R. Huang, J. Huang, J. Hugon, J. Iles, G. and Ilic, N. Iliescu, A. M. Illingworth, R. Ioannisian, A. and Itay, R. Izmaylov, A. James, E. Jargowsky, B. Jediny, F. and Jesus-Valls, C. Ji, X. Jiang, L. Jimenez, S. Jipa, A. Joglekar, A. Johnson, C. Johnson, R. Jones, B. and Jones, S. Jung, C. K. Junk, T. Jwa, Y. Kabirnezhad, M. and Kaboth, A. Kadenko, I. Kamiya, F. Karagiorgi, G. and Karcher, A. Karolak, M. Karyotakis, Y. Kasai, S. and Kasetti, S. P. Kashur, L. Kazaryan, N. Kearns, E. and Keener, P. Kelly, K. J. Kemp, E. Ketchum, W. Kettell, S. H. Khabibullin, M. Khotjantsev, A. Khvedelidze, A. Kim, D. King, B. Kirby, B. Kirby, M. Klein, J. Koehler, K. Koerner, L. W. Kohn, S. Koller, P. P. Kordosky, M. and Kosc, T. Kose, U. Kostelecky, V. A. Kothekar, K. and Krennrich, F. Kreslo, I. Kudenko, Y. Kudryavtsev, V. A. and Kulagin, S. Kumar, J. Kumar, R. Kuruppu, C. Kus, V. and Kutter, T. Lambert, A. Lande, K. Lane, C. E. Lang, K. and Langford, T. Lasorak, P. Last, D. Lastoria, C. and Laundrie, A. Lawrence, A. Lazanu, I. Lazur, R. Le, T. and Learned, J. LeBrun, P. Miotto, G. Lehmann Lehnert, R. and Leigui de Oliveira, M. A. Leitner, M. Leyton, M. Li, L. and Li, S. Li, S. W. Li, T. Li, Y. Liao, H. Lin, C. S. Lin, S. Lister, A. Littlejohn, B. R. Liu, J. and Lockwitz, S. Loew, T. Lokajicek, M. Lomidze, I. Long, K. and Loo, K. Lorca, D. Lord, T. LoSecco, J. M. Louis, W. C. Luk, K. B. Luo, X. Lurkin, N. Lux, T. Luzio, V. P. MacFarland, D. Machado, A. A. Machado, P. Macias, C. T. Macier, J. R. Maddalena, A. Madigan, P. Magill, S. and Mahn, K. Maio, A. Maloney, J. A. Mandrioli, G. and Maneira, J. Manenti, L. Manly, S. Mann, A. Manolopoulos, K. Manrique Plata, M. Marchionni, A. Marciano, W. and Marfatia, D. Mariani, C. Maricic, J. Marinho, F. Marino, A. D. Marshak, M. Marshall, C. Marshall, J. Marteau, J. and Martin-Albo, J. Martinez, N. Caicedo, D. A. Martinez and Martynenko, S. Mason, K. Mastbaum, A. Masud, M. Matsuno, S. Matthews, J. Mauger, C. Mauri, N. Mavrokoridis, K. and Mazza, R. Mazzacane, A. Mazzucato, E. McCluskey, E. and McConkey, N. McFarland, K. S. McGrew, C. Mcnab, A. and Mefodiev, A. Mehta, P. Melas, P. Mellinato, M. Mena, O. and Menary, S. Mendez, H. Menegolli, A. Meng, G. and Messier, M. D. Metcalf, W. Mewes, M. Meyer, H. Miao, T. and Michna, G. Miedema, T. Migenda, J. Milincic, R. and Miller, W. Mills, J. Milne, C. Mineev, O. Miranda, O. G. and Miryala, S. Mishra, C. S. Mishra, S. R. Mislivec, A. and Mladenov, D. Mocioiu, I. Moffat, K. Moggi, N. Mohanta, R. Mohayai, T. A. Mokhov, N. Molina, J. Bueno, L. Molina and Montanari, A. Montanari, C. Montanari, D. Montano Zetina, L. M. Moon, J. Mooney, M. Moor, A. Moreno, D. and Morgan, B. Morris, C. Mossey, C. Motuk, E. Moura, C. A. Mousseau, J. Mu, W. Mualem, L. Mueller, J. and Muether, M. Mufson, S. Muheim, F. Muir, A. Mulhearn, M. and Muramatsu, H. Murphy, S. Musser, J. Nachtman, J. and Nagu, S. Nalbandyan, M. Nandakumar, R. Naples, D. and Narita, S. Navas-Nicolas, D. Nayak, N. Nebot-Guinot, M. and Necib, L. Negishi, K. Nelson, J. K. Nesbit, J. Nessi, M. and Newbold, D. Newcomer, M. Newhart, D. Nichol, R. and Niner, E. Nishimura, K. Norman, A. Norrick, A. Northrop, R. Novella, P. Nowak, J. A. Oberling, M. Del Campo, A. Olivares Olivier, A. Onel, Y. Onishchuk, Y. Ott, J. and Pagani, L. Pakvasa, S. Palamara, O. Palestini, S. Paley, J. M. Pallavicini, M. Palomares, C. Pantic, E. Paolone, V. Papadimitriou, V. Papaleo, R. Papanestis, A. and Paramesvaran, S. Parke, S. Parsa, Z. Parvu, M. Pascoli, S. Pasqualini, L. Pasternak, J. Pater, J. Patrick, C. and Patrizii, L. Patterson, R. B. Patton, S. J. Patzak, T. and Paudel, A. Paulos, B. Paulucci, L. Pavlovic, Z. and Pawloski, G. Payne, D. Pec, V. Peeters, S. J. M. and Penichot, Y. Pennacchio, E. Penzo, A. Peres, O. L. G. and Perry, J. Pershey, D. Pessina, G. Petrillo, G. Petta, C. and Petti, R. Piastra, F. Pickering, L. Pietropaolo, F. and Pillow, J. Pinzino, J. Plunkett, R. Poling, R. Pons, X. and Poonthottathil, N. Pordes, S. Potekhin, M. Potenza, R. and Potukuchi, B. V. K. S. Pozimski, J. Pozzato, M. Prakash, S. Prakash, T. Prince, S. Prior, G. Pugnere, D. Qi, K. Qian, X. Raaf, J. L. Raboanary, R. Radeka, V. and Rademacker, J. Radics, B. Radovic, A. Rafique, A. and Raguzin, E. Rai, M. Rajaoalisoa, M. Rakhno, I. and Rakotondramanana, H. T. Rakotondravohitra, L. Ramachers, Y. A. and Rameika, R. Delgado, M. A. Ramirez Ramson, B. Rappoldi, A. Raselli, G. Ratoff, P. Ravat, S. Razafinime, H. and Real, J. S. Rebel, B. Redondo, D. Reggiani-Guzzo, M. and Rehak, T. Reichenbacher, J. Reitzner, S. D. Renshaw, A. and Rescia, S. Resnati, F. Reynolds, A. Riccobene, G. Rice, L. C. J. Rielage, K. Rigaut, Y. Rivera, D. Rochester, L. and Roda, M. Rodrigues, P. Alonso, M. J. Rodriguez Rondon, J. Rodriguez Roeth, A. J. Rogers, H. Rosauro-Alcaraz, S. and Rossella, M. Rout, J. Roy, S. Rubbia, A. Rubbia, C. and Russell, B. Russell, J. Ruterbories, D. Saakyan, R. and Sacerdoti, S. Safford, T. Sahu, N. Sala, P. Samios, N. and Sanchez, M. C. Sanders, D. A. Sankey, D. Santana, S. and Santos-Maldonado, M. Saoulidou, N. Sapienza, P. Sarasty, C. and Sarcevic, I. Savage, G. Savinov, V. Scaramelli, A. and Scarff, A. Scarpelli, A. Schaffer, T. Schellman, H. and Schlabach, P. Schmitz, D. Scholberg, K. Schukraft, A. and Segreto, E. Sensenig, J. Seong, I. Sergi, A. and Sergiampietri, F. Sgalaberna, D. Shaevitz, M. H. Shafaq, S. and Shamma, M. Sharma, H. R. Sharma, R. Shaw, T. and Shepherd-Themistocleous, C. Shin, S. Shooltz, D. Shrock, R. and Simard, L. Simos, N. Sinclair, J. Sinev, G. Singh, J. Singh, J. Singh, V. Sipos, R. Sippach, F. W. and Sirri, G. Sitraka, A. Siyeon, K. Smargianaki, D. Smith, A. Smith, A. Smith, E. Smith, P. Smolik, J. Smy, M. and Snopok, P. Soares Nunes, M. Sobel, H. Soderberg, M. and Salinas, C. J. Solano Soldner-Rembold, S. Solomey, N. and Solovov, V. Sondheim, W. E. Sorel, M. Soto-Oton, J. and Sousa, A. Soustruznik, K. Spagliardi, F. Spanu, M. and Spitz, J. Spooner, N. J. C. Spurgeon, K. Staley, R. and Stancari, M. Stanco, L. Steiner, H. M. Stewart, J. and Stillwell, B. Stock, J. Stocker, F. Stokes, T. Strait, M. Strauss, T. Striganov, S. Stuart, A. Summers, D. and Surdo, A. Susic, V. Suter, L. Sutera, C. M. Svoboda, R. and Szczerbinska, B. Szelc, A. M. Talaga, R. Tanaka, H. A. and Oregui, B. Tapia Tapper, A. Tariq, S. Tatar, E. and Tayloe, R. Teklu, A. M. Tenti, M. Terao, K. Ternes, C. A. Terranova, F. Testera, G. Thea, A. Thompson, J. L. and Thorn, C. Timm, S. C. Tonazzo, A. Torti, M. Tortola, M. Tortorici, F. Totani, D. Toups, M. Touramanis, C. and Trevor, J. Trzaska, W. H. Tsai, Y. T. Tsamalaidze, Z. and Tsang, K. V. Tsverava, N. Tufanli, S. Tull, C. Tyley, E. and Tzanov, M. Uchida, M. A. Urheim, J. Usher, T. and Vagins, M. R. Vahle, P. Valdiviesso, G. A. Valencia, E. and Vallari, Z. Valle, J. W. F. Vallecorsa, S. Van Berg, R. and Van de Water, R. G. Vanegas Forero, D. Varanini, F. Vargas, D. Varner, G. Vasel, J. Vasseur, G. Vaziri, K. and Ventura, S. Verdugo, A. Vergani, S. Vermeulen, M. A. and Verzocchi, M. Vieira de Souza, H. Vignoli, C. Vilela, C. and Viren, B. Vrba, T. Wachala, T. Waldron, A. V. Wallbank, M. Wang, H. Wang, J. Wang, Y. Wang, Y. Warburton, K. and Warner, D. Wascko, M. Waters, D. Watson, A. and Weatherly, P. Weber, A. Weber, M. Wei, H. Weinstein, A. and Wenman, D. Wetstein, M. While, M. R. White, A. and Whitehead, L. H. Whittington, D. Wilking, M. J. Wilkinson, C. Williams, Z. Wilson, F. Wilson, R. J. Wolcott, J. and Wongjirad, T. Wood, K. Wood, L. Worcester, E. Worcester, M. Wret, C. Wu, W. Wu, W. Xiao, Y. Yang, G. and Yang, T. Yershov, N. Yonehara, K. Young, T. Yu, B. and Yu, J. Zaki, R. Zalesak, J. Zambelli, L. Zamorano, B. and Zani, A. Zazueta, L. Zeller, G. P. Zennamo, J. Zeug, K. Zhang, C. Zhao, M. Zhivun, E. Zhu, G. Zimmerman, E. D. Zito, M. Zucchelli, S. Zuklin, J. Zutshi, V. and Zwaska, R. DUNE Collaboration
Subjects: Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, High Energy Physics::Phenomenology, High Energy Physics::Experiment
Abstract: The Deep Underground Neutrino Experiment is a next-generation neutrino oscillation experiment that aims to measure CP-violation in the neutrino sector as part of a wider physics program. A deep learning approach based on a convolutional neural network has been developed to provide highly efficient and pure selections of electron neutrino and muon neutrino charged-current interactions. The electron neutrino (antineutrino) selection efficiency peaks at 90% (94%) and exceeds 85% (90%) for reconstructed neutrino energies between 2-5 GeV. The muon neutrino (antineutrino) event selection is found to have a maximum efficiency of 96% (97%) and exceeds 90% (95%) efficiency for reconstructed neutrino energies above 2 GeV. When considering all electron neutrino and antineutrino interactions as signal, a selection purity of 90% is achieved. These event selections are critical to maximize the sensitivity of the experiment to CP-violating effects.
Published: 2020

19. Volume III DUNE far detector technical coordination

Author: Abi, B. Acciarri, R. Acero, M. A. Adamov, G. Adams, D. and Adinolfi, M. Ahmad, Z. Ahmed, J. Alion, T. Monsalve, S. Alonso Alt, C. Anderson, J. Andreopoulos, C. Andrews, M. Andrianala, F. Andringa, S. Ankowski, A. Antonova, M. and Antusch, S. Aranda-Fernandez, A. Ariga, A. Arnold, L. O. and Arroyave, M. A. Asaadi, J. Aurisano, A. Aushev, V and Autiero, D. Azfar, F. Back, H. Back, J. J. Backhouse, C. and Baesso, P. Bagby, L. Bajou, R. Balasubramanian, S. and Baldi, P. Bambah, B. Barao, F. Barenboim, G. Barker, G. and Barkhouse, W. Barnes, C. Barr, G. Barranco Monarca, J. and Barros, N. Barrow, J. L. Bashyal, A. Basque, V Bay, F. Bazo Alba, J. Beacom, J. F. Bechetoille, E. Behera, B. Bellantoni, L. Bellettini, G. Bellini, V Beltramello, O. Belver, D. Benekos, N. Neves, F. Bento Berger, J. and Berkman, S. Bernardini, P. Berner, R. M. Berns, H. and Bertolucci, S. Betancourt, M. Bezawada, Y. Bhattacharjee, M. and Bhuyan, B. Biagi, S. Bian, J. Biassoni, M. Biery, K. and Bilki, B. Bishai, M. Bitadze, A. Blake, A. Siffert, B. Blanco Blaszczyk, F. Blazey, G. Blucher, E. and Boissevain, J. Bolognesi, S. Bolton, T. Bonesini, M. and Bongrand, M. Bonini, F. Booth, A. Booth, C. Bordoni, S. and Borkum, A. Boschi, T. Bostan, N. Bour, P. Boyd, S. and Boyden, D. Bracinik, J. Braga, D. Brailsford, D. and Brandt, A. Bremer, J. Brew, C. Brianne, E. Brice, S. J. and Brizzolari, C. Bromberg, C. Brooijmans, G. Brooke, J. and Bross, A. Brunetti, G. Buchanan, N. Budd, H. Caiulo, D. Calafiura, P. Calcutt, J. Calin, M. Calvez, S. and Calvo, E. Camilleri, L. Caminata, A. Campanelli, M. and Caratelli, D. Carini, G. Carlus, B. Carniti, P. and Terrazas, I. Caro Carranza, H. Castillo, A. Castromonte, C. and Cattadori, C. Cavalier, F. Cavanna, F. Centro, S. and Cerati, G. Cervelli, A. Cervera Villanueva, A. Chalifour, M. and Chang, C. Chardonnet, E. Chatterjee, A. Chattopadhyay, S. Chaves, J. Chen, H. Chen, M. Chen, Y. Cherdack, D. Chi, C. Childress, S. Chiriacescu, A. Cho, K. and Choubey, S. Christensen, A. Christian, D. Christodoulou, G. and Church, E. Clarke, P. Coan, T. E. Cocco, A. G. and Coelho, J. Conley, E. Conrad, J. Convery, M. Corwin, L. and Cotte, P. Cremaldi, L. Cremonesi, L. Crespo-Anadon, I, J. Cristaldo, E. Cross, R. Cuesta, C. Cui, Y. and Cussans, D. Dabrowski, M. Da Motta, H. Peres, L. Da Silva and David, Q. Davies, G. S. Davini, S. Dawson, J. De, K. and De Almeida, R. M. Debbins, P. De Bonis, I Decowski, M. and De Gouvea, A. De Holanda, P. C. Astiz, I. L. De Icaza and Deisting, A. De Jong, P. Delbart, A. Delepine, D. and Delgado, M. Dell'Acqua, A. De Lurgio, P. De Mello Neto, J. R. DeMuth, D. M. Dennis, S. Densham, C. Deptuch, G. and De Roeck, A. De Romeri, V De Vries, J. Dharmapalan, R. and Dias, M. Diaz, F. Diaz, J. Di Domizio, S. Di Giulio, L. and Ding, P. Di Noto, L. Distefano, C. Diurba, R. Diwan, M. Djurcic, Z. Dokania, N. Dolinski, M. Domine, L. and Douglas, D. Drielsma, F. Duchesneau, D. Duffy, K. Dunne, P. Durkin, T. Duyang, H. Dvornikov, O. Dwyer, D. and Dyshkant, A. Eads, M. Edmunds, D. Eisch, J. Emery, S. and Ereditato, A. Escobar, C. Sanchez, L. Escudero Evans, J. J. Ewart, E. Ezeribe, A. C. Fahey, K. Falcone, A. and Farnese, C. Farzan, Y. Felix, J. Fernandez-Martinez, E. and Fernandez Menendez, P. Ferraro, F. Fields, L. Filkins, A. and Filthaut, F. Fitzpatrick, R. S. Flanagan, W. Fleming, B. and Flight, R. Fowler, J. Fox, W. Franc, J. Francis, K. and Franco, D. Freeman, J. Freestone, J. Fried, J. and Friedland, A. Fuess, S. Furic, I Furmanski, A. P. Gago, A. Gallagher, H. Gallego-Ros, A. Gallice, N. Galymov, V and Gamberini, E. Gamble, T. Gandhi, R. Gandrajula, R. and Gao, S. Garcia-Gamez, D. Garcia-Peris, M. A. Gardiner, S. and Gastler, D. Ge, G. Gelli, B. Gendotti, A. Gent, S. and Ghorbani-Moghaddam, Z. Gibin, D. Gil-Botella, I Girerd, C. Giri, A. Gnani, D. Gogota, O. Gold, M. and Gollapinni, S. Gollwitzer, K. Gomes, R. A. Gomez Bermeo, L. and Gomez Fajardo, L. S. Gonnella, F. Gonzalez-Cuevas, J. and Goodman, M. C. Goodwin, O. Goswami, S. Gotti, C. and Goudzovski, E. Grace, C. Graham, M. Gramellini, E. Gran, R. Granados, E. Grant, A. Grant, C. Gratieri, D. and Green, P. Green, S. Greenler, L. Greenwood, M. Greer, J. and Griffith, C. Groh, M. Grudzinski, J. Grzelak, K. Gu, W. Guarino, V Guenette, R. Guglielmi, A. Guo, B. and Guthikonda, K. Gutierrez, R. Guzowski, P. Guzzo, M. M. and Gwon, S. Habig, A. Hackenburg, A. Hadavand, H. Haenni, R. Hahn, A. Haigh, J. Haiston, J. Hamernik, T. and Hamilton, P. Han, J. Harder, K. Harris, D. A. Hartnell, J. Hasegawa, T. Hatcher, R. Hazen, E. Heavey, A. and Heeger, K. M. Hennessy, K. Henry, S. Hernandez Morquecho, M. and Herner, K. Hertel, L. Hesam, A. S. Hewes, J. and Pichardo, A. Higuera Hill, T. Hillier, S. J. Himmel, A. and Hoff, J. Hohl, C. Holin, A. Hoppe, E. Horton-Smith, G. A. Hostert, M. Hourlier, A. Howard, B. Howell, R. and Huang, J. Huang, J. Hugon, J. Iles, G. Iliescu, A. M. and Illingworth, R. Ioannisian, A. Itay, R. Izmaylov, A. and James, E. Jargowsky, B. Jediny, F. Jesus-Valls, C. Ji, X. Jiang, L. Jimenez, S. Jipa, A. Joglekar, A. and Johnson, C. Johnson, R. Jones, B. Jones, S. Jung, C. and Junk, T. Jwa, Y. Kabirnezhad, M. Kaboth, A. Kadenko, I and Kamiya, F. Karagiorgi, G. Karcher, A. Karolak, M. and Karyotakis, Y. Kasai, S. Kasetti, S. P. Kashur, L. and Kazaryan, N. Kearns, E. Keener, P. Kelly, K. J. Kemp, E. and Ketchum, W. Kettell, S. Khabibullin, M. Khotjantsev, A. and Khvedelidze, A. Kim, D. King, B. Kirby, B. Kirby, M. and Klein, J. Koehler, K. Koerner, L. W. Kohn, S. and Koller, P. P. Kordosky, M. Kosc, T. Kose, U. Kostelecky, V Kothekar, K. Krennrich, F. Kreslo, I Kudenko, Y. and Kudryavtsev, V Kulagin, S. Kumar, J. Kumar, R. Kuruppu, C. Kus, V Kutter, T. Lambert, A. Lande, K. Lane, C. E. Lang, K. Langford, T. Lasorak, P. Last, D. and Lastoria, C. Laundrie, A. Lawrence, A. Lazanu, I LaZur, R. Le, T. Learned, J. LeBrun, P. Miotto, G. Lehmann and Lehnert, R. de Oliveira, M. Leigui Leitner, M. Leyton, M. and Li, L. Li, S. Li, S. Li, T. Li, Y. Liao, H. and Lin, C. Lin, S. Lister, A. Littlejohn, B. R. Liu, J. and Lockwitz, S. Loew, T. Lokajicek, M. Lomidze, I Long, K. and Loo, K. Lorca, D. Lord, T. LoSecco, J. Louis, W. C. and Luk, K. Luo, X. Lurkin, N. Lux, T. Luzio, V. P. and MacFarland, D. Machado, A. Machado, P. Macias, C. and Macier, J. Maddalena, A. Madigan, P. Magill, S. Mahn, K. and Maio, A. Maloney, J. A. Mandrioli, G. Maneira, J. C. and Manenti, L. Manly, S. Mann, A. Manolopoulos, K. Plata, M. Manrique Marchionni, A. Marciano, W. Marfatia, D. and Mariani, C. Maricic, J. Marinho, F. Marino, A. D. and Marshak, M. Marshall, C. Marshall, J. Marteau, J. and Martin-Albo, J. Martinez, N. Caicedo, D. A. Martinez and Martynenko, S. Mason, K. Mastbaum, A. Masud, M. Matsuno, S. Matthews, J. Mauger, C. Mauri, N. Mavrokoridis, K. and Mazza, R. Mazzacane, A. Mazzucato, E. McCluskey, E. and McConkey, N. McFarland, K. S. McGrew, C. McNab, A. and Mefodiev, A. Mehta, P. Melas, P. Mellinato, M. Mena, O. and Menary, S. Mendez, H. Menegolli, A. Meng, G. and Messier, M. Metcalf, W. Mewes, M. Meyer, H. Miao, T. and Michna, G. Miedema, T. Migenda, J. Milincic, R. Miller, W. Mills, J. Milne, C. Mineev, O. Miranda, O. G. and Miryala, S. Mishra, C. Mishra, S. Mislivec, A. Mladenov, D. Mocioiu, I Moffat, K. Moggi, N. Mohanta, R. and Mohayai, T. A. Mokhov, N. Molina, J. A. Bueno, L. Molina and Montanari, A. Montanari, C. Montanari, D. Montano Zetina, L. M. Moon, J. Mooney, M. Moor, A. Moreno, D. Morgan, B. Morris, C. Mossey, C. Motuk, E. Moura, C. A. and Mousseau, J. Mu, W. Mualem, L. Mueller, J. Muether, M. and Mufson, S. Muheim, F. Muir, A. Mulhearn, M. and Muramatsu, H. Murphy, S. Musser, J. Nachtman, J. Nagu, S. Nalbandyan, M. Nandakumar, R. Naples, D. Narita, S. and Navas-Nicolas, D. Nayak, N. Nebot-Guinot, M. Necib, L. and Negishi, K. Nelson, J. K. Nesbit, J. Nessi, M. and Newbold, D. Newcomer, M. Newhart, D. Nichol, R. Niner, E. Nishimura, K. Norman, A. Northrop, R. Novella, P. and Nowak, J. A. Oberling, M. Del Campo, A. Olivares Olivier, A. and Onel, Y. Onishchuk, Y. Ott, J. Pagani, L. Pakvasa, S. Palamara, O. Palestini, S. Paley, J. M. Pallavicini, M. Palomares, C. Pantic, E. Paolone, V Papadimitriou, V and Papaleo, R. Papanestis, A. Paramesvaran, S. Parke, S. and Parsa, Z. Parvu, M. Pascoli, S. Pasqualini, L. and Pasternak, J. Pater, J. Patrick, C. Patrizii, L. and Patterson, R. B. Patton, S. Patzak, T. Paudel, A. and Paulos, B. Paulucci, L. Pavlovic, Z. Pawloski, G. Payne, D. Pec, V Peeters, S. J. Penichot, Y. Pennacchio, E. and Penzo, A. Peres, O. L. Perry, J. Pershey, D. Pessina, G. and Petrillo, G. Petta, C. Petti, R. Piastra, F. and Pickering, L. Pietropaolo, F. Pillow, J. Plunkett, R. and Poling, R. Pons, X. Poonthottathil, N. Pordes, S. and Potekhin, M. Potenza, R. Potukuchi, V, B. Pozimski, J. and Pozzato, M. Prakash, S. Prakash, T. Prince, S. Prior, G. and Pugnere, D. Qi, K. Qian, X. Raaf, J. Raboanary, R. and Radeka, V Rademacker, J. Radics, B. Rafique, A. and Raguzin, E. Rai, M. Rajaoalisoa, M. Rakhno, I and Rakotondramanana, H. Rakotondravohitra, L. Ramachers, Y. and Rameika, R. Delgado, M. Ramirez Ramson, B. Rappoldi, A. and Raselli, G. Ratoff, P. Ravat, S. Razafinime, H. Real, J. and Rebel, B. Redondo, D. Reggiani-Guzzo, M. Rehak, T. and Reichenbacher, J. Reitzner, S. D. Renshaw, A. Rescia, S. and Resnati, F. Reynolds, A. Riccobene, G. Rice, L. C. and Rielage, K. Rigaut, Y. Rivera, D. Rochester, L. Roda, M. and Rodrigues, P. Alonso, M. Rodriguez Rondon, J. Rodriguez and Roeth, A. Rogers, H. Rosauro-Alcaraz, S. Rossella, M. and Rout, J. Roy, S. Rubbia, A. Rubbia, C. Russell, B. and Russell, J. Ruterbories, D. Saakyan, R. Sacerdoti, S. and Safford, T. Sahu, N. Sala, P. Samios, N. Sanchez, M. and Sanders, D. A. Sankey, D. Santana, S. Santos-Maldonado, M. and Saoulidou, N. Sapienza, P. Sarasty, C. Sarcevic, I and Savage, G. Savinov, V Scaramelli, A. Scarff, A. and Scarpelli, A. Schaffer, T. Schellman, H. Schlabach, P. and Schmitz, D. Scholberg, K. Schukraft, A. Segreto, E. and Sensenig, J. Seong, I Sergi, A. Sergiampietri, F. and Sgalaberna, D. Shaevitz, M. Shafaq, S. Shamma, M. and Sharma, H. R. Sharma, R. Shaw, T. Shepherd-Themistocleous, C. Shin, S. Shooltz, D. Shrock, R. Simard, L. Simos, N. Sinclair, J. Sinev, G. Singh, J. Singh, J. Singh, V Sipos, R. Sippach, F. Sirri, G. Sitraka, A. and Siyeon, K. Smargianaki, D. Smith, A. Smith, A. Smith, E. and Smith, P. Smolik, J. Smy, M. Snopok, P. Nunes, M. Soares Sobel, H. Soderberg, M. Solano Salinas, C. J. and Soldner-Rembold, S. Solomey, N. Solovov, V Sondheim, W. E. and Sorel, M. Soto-Oton, J. Sousa, A. Soustruznik, K. and Spagliardi, F. Spanu, M. Spitz, J. Spooner, N. J. and Spurgeon, K. Staley, R. Stancari, M. Stanco, L. Steiner, H. Stewart, J. Stillwell, B. Stock, J. Stocker, F. and Stokes, T. Strait, M. Strauss, T. Striganov, S. Stuart, A. Summers, D. Surdo, A. Susic, V Suter, L. Sutera, C. Svoboda, R. Szczerbinska, B. Szelc, A. Talaga, R. and Tanaka, H. Oregui, B. Tapia Tapper, A. Tariq, S. Tatar, E. Tayloe, R. Teklu, A. Tenti, M. Terao, K. Ternes, C. A. Terranova, F. Testera, G. Thea, A. Thompson, J. L. and Thorn, C. Timm, S. Tonazzo, A. Torti, M. Tortola, M. and Tortorici, F. Totani, D. Toups, M. Touramanis, C. and Trevor, J. Trzaska, W. H. Tsai, Y. T. Tsamalaidze, Z. and Tsang, K. Tsverava, N. Tufanli, S. Tull, C. Tyley, E. and Tzanov, M. Uchida, M. A. Urheim, J. Usher, T. and Vagins, M. Vahle, P. Valdiviesso, G. Valencia, E. and Vallari, Z. Valle, J. W. Vallecorsa, S. Van Berg, R. Van de Water, R. G. Forero, D. Vanegas Varanini, F. Vargas, D. and Varner, G. Vasel, J. Vasseur, G. Vaziri, K. Ventura, S. Verdugo, A. Vergani, S. Vermeulen, M. A. Verzocchi, M. de Souza, H. Vieira Vignoli, C. Vilela, C. Viren, B. and Vrba, T. Wachala, T. Waldron, V, A. Wallbank, M. and Wang, H. Wang, J. Wang, Y. Wang, Y. Warburton, K. and Warner, D. Wascko, M. Waters, D. Watson, A. Weatherly, P. Weber, A. Weber, M. Wei, H. Weinstein, A. Wenman, D. Wetstein, M. While, M. R. White, A. Whitehead, L. H. and Whittington, D. Wilking, M. J. Wilkinson, C. Williams, Z. Wilson, F. Wilson, R. J. Wolcott, J. Wongjirad, T. and Wood, K. Wood, L. Worcester, E. Worcester, M. Wret, C. Wu, W. Wu, W. Xiao, Y. Yang, G. Yang, T. and Yershov, N. Yonehara, K. Young, T. Yu, B. Yu, J. and Zalesak, J. Zambelli, L. Zamorano, B. Zani, A. Zazueta, L. Zeller, G. Zennamo, J. Zeug, K. Zhang, C. Zhao, M. Zhivun, E. Zhu, G. Zimmerman, E. D. Zito, M. and Zucchelli, S. Zuklin, J. Zutshi, V Zwaska, R. DUNE Collaboration
Published: 2020

20. Clinical indications for image-guided interventional procedures in the musculoskeletal system: a Delphi-based consensus paper from the European Society of Musculoskeletal Radiology (ESSR)—part I, shoulder

Author: Sconfienza, L.M. Adriaensen, M. Albano, D. Allen, G. Aparisi Gómez, M.P. Bazzocchi, A. Beggs, I. Bignotti, B. Chianca, V. Corazza, A. Dalili, D. De Dea, M. del Cura, J.L. Di Pietto, F. Drakonaki, E. Facal de Castro, F. Filippiadis, D. Gielen, J. Gitto, S. Gupta, H. Klauser, A.S. Lalam, R. Martin, S. Martinoli, C. Mauri, G. McCarthy, C. McNally, E. Melaki, K. Messina, C. Mirón Mombiela, R. Neubauer, B. Olchowy, C. Orlandi, D. Plagou, A. Prada Gonzalez, R. Rutkauskas, S. Snoj, Z. Tagliafico, A.S. Talaska, A. Vasilevska-Nikodinovska, V. Vucetic, J. Wilson, D. Zaottini, F. Zappia, M. Obradov, M.
Abstract: Background: Image-guided interventional procedures around the shoulder are commonly performed in clinical practice, although evidence regarding their effectiveness is scarce. We report the results of a Delphi method review of evidence on literature published on image-guided interventional procedures around the shoulder with a list of clinical indications. Methods: Forty-five experts in image-guided musculoskeletal procedures from the ESSR participated in a consensus study using the Delphic method. Peer-reviewed papers regarding interventional procedures around the shoulder up to September 2018 were scored according to the Oxford Centre for Evidence-based Medicine levels of evidence. Statements on clinical indications were constructed. Consensus was considered as strong if more than 95% of experts agreed and as broad if more than 80% agreed. Results: A total of 20 statements were drafted, and 5 reached the highest level of evidence. There were 10 statements about tendon procedures, 6 about intra-articular procedures, and 4 about intrabursal injections. Strong consensus was obtained in 16 of them (80%), while 4 received broad consensus (20%). Conclusions: Literature evidence on image-guided interventional procedures around the shoulder is limited. A strong consensus has been reached for 80% of statements. The ESSR recommends further research to potentially influence treatment options, patient outcomes, and social impact. Key Points: • Expert consensus produced a list of 20 evidence-based statements on clinical indications of image-guided interventional procedures around the shoulder. • The highest level of evidence was reached for five statements. • Strong consensus was obtained for 16 statements (80%), while 4 received broad consensus (20%). © 2019, European Society of Radiology.
Published: 2020

21. Clinical indications for image guided interventional procedures in the musculoskeletal system: a Delphi-based consensus paper from the European Society of Musculoskeletal Radiology (ESSR)—part III, nerves of the upper limb

Author: Sconfienza, L.M. Adriaensen, M. Albano, D. Allen, G. Aparisi Gómez, M.P. Bazzocchi, A. Beggs, I. Bignotti, B. Chianca, V. Corazza, A. Dalili, D. De Dea, M. del Cura, J.L. Di Pietto, F. Drakonaki, E. Facal de Castro, F. Filippiadis, D. Gielen, J. Gitto, S. Gupta, H. Klauser, A.S. Lalam, R. Martin, S. Martinoli, C. Mauri, G. McCarthy, C. McNally, E. Melaki, K. Messina, C. Mirón Mombiela, R. Neubauer, B. Obradov, M. Olchowy, C. Orlandi, D. Gonzalez, R.P. Rutkauskas, S. Snoj, Z. Tagliafico, A.S. Talaska, A. Vasilevska-Nikodinovska, V. Vucetic, J. Wilson, D. Zaottini, F. Zappia, M. Plagou, A. on behalf of the Ultrasound Interventional Subcommittees of the European Society of Musculoskeletal Radiology (ESSR)
Abstract: Background: Image-guided interventional procedures of the nerves are commonly performed by physicians from different medical specialties, although there is a lack of clinical indications for these types of procedures. This Delphi-based consensus provided a list of indications on image-guided interventional procedures for nerves of the upper limb based on updated published evidence. Methods: An expert panel of 45 members of the Ultrasound and Interventional Subcommittees of the ESSR participated in this Delphi-based consensus study. After revision of the published papers on image-guided interventional procedures for nerves of the upper limb updated to September 2018, the experts drafted a list of statements according to the Oxford Centre for evidence-based medicine levels of evidence. Consensus on statements regarding clinical indications was considered as strong when more than 95% of experts agreed, and broad if more than 80% agreed. Results: Ten statements were drafted on procedures for nerves of the upper limb. Only two statements reached the highest level of evidence (ultrasound guidance is a safe and effective method for brachial plexus block; ultrasound-guided non-surgical approaches are safe and effective methods to treat carpal tunnel syndrome in the short term, but there is sparse evidence on the mid- and long-term effectiveness of these interventions). Strong consensus was obtained on 6/10 statements (60%), while 4/10 statements reached broad consensus (40%). Conclusions: This Delphi-based consensus study reported poor evidence on image-guided interventional procedures for nerves of the upper limb. Sixty percent of statements on clinical indications provided by the expert board reached a strong consensus. Key Points: • An expert panel of the ESSR provided 10 evidence-based statements on clinical indications for image-guided interventional procedures for nerves of the upper limb • Two statements reached the highest level of evidence • Strong consensus was obtained on 6/10 statements (60%), while 4/10 statements reached broad consensus (40%) © 2019, European Society of Radiology.
Published: 2020

22. Clinical indications for image-guided interventional procedures in the musculoskeletal system: a Delphi-based consensus paper from the European Society of Musculoskeletal Radiology (ESSR)—Part II, elbow and wrist

Author: Sconfienza, L.M. Adriaensen, M. Albano, D. Aparisi Gómez, M.P. Bazzocchi, A. Beggs, I. Bignotti, B. Chianca, V. Corazza, A. Dalili, D. De Dea, M. del Cura, J.L. Di Pietto, F. Drakonaki, E. Facal de Castro, F. Filippiadis, D. Gielen, J. Gitto, S. Gupta, H. Klauser, A.S. Lalam, R. Martin, S. Martinoli, C. Mauri, G. McCarthy, C. McNally, E. Melaki, K. Messina, C. Mirón Mombiela, R. Neubauer, B. Obradov, M. Olchowy, C. Orlandi, D. Plagou, A. Prada Gonzalez, R. Rutkauskas, S. Snoj, Z. Tagliafico, A.S. Talaska, A. Vasilevska-Nikodinovska, V. Vucetic, J. Wilson, D. Zaottini, F. Zappia, M. Allen, G. on behalf of the Ultrasound Interventional Subcommittees of the European Society of Musculoskeletal Radiology (ESSR)
Abstract: Background: Although image-guided interventional procedures of the elbow and wrist are routinely performed, there is poor evidence in the literature concerning such treatments. Our aim was to perform a Delphi-based consensus on published evidence on image-guided interventional procedures around the elbow and wrist and provide clinical indications on this topic. Methods: A board of 45 experts in image-guided interventional musculoskeletal procedures from the European Society of Musculoskeletal Radiology were involved in this Delphi-based consensus study. All panelists reviewed and scored published papers on image-guided interventional procedures around the elbow and wrist updated to September 2018 according to the Oxford Centre for Evidence-based Medicine levels of evidence. Consensus on statements drafted by the panelists about clinical indications was considered as “strong” when more than 95% of panelists agreed and as “broad” if more than 80% agreed. Results: Eighteen statements were drafted, 12 about tendon procedures and 6 about intra-articular procedures. Only statement #15 reached the highest level of evidence (ultrasound-guided steroid wrist injections result in greater pain reduction and greater likelihood of attaining clinically important improvement). Seventeen statements received strong consensus (94%), while one received broad consensus (6%). Conclusions: There is still poor evidence in published papers on image-guided interventional procedures around the elbow and wrist. A strong consensus has been achieved in 17/18 (94%) statements provided by the panel on clinical indications. Large prospective randomized trials are needed to better define the role of these procedures in clinical practice. Key Points: • The panel provided 18 evidence-based statements on clinical indications of image-guided interventional procedures around the elbow and wrist. • Only statement #15 reached the highest level of evidence: ultrasound-guided steroid wrist injections result in greater pain reduction and greater likelihood of attaining clinically important improvement. • Seventeen statements received strong consensus (94%), while broad consensus was obtained by 1 statement (6%). © 2019, European Society of Radiology.
Published: 2020

23. Studies on the Absorption of TCDD by Plant Species

Author: G. Frare, S. Facchetti, C. Fichtner, A. Balasso, M. Vasconi, A. Leoni, and C. Mauri
Subjects: Chemistry, Plant species, Absorption (electromagnetic radiation), Photochemistry
Published: 2018
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24. Hallucinations in the Substance-Induced Psychosis

Author: Massimo C. Mauri, Silvia Paletta, and Chiara Di Pace
Subjects: Formication, medicine.medical_specialty, business.industry, Medicine, Substance use, medicine.symptom, business, medicine.disease, Psychiatry, Substance-induced psychosis, Visual Hallucination
Abstract: Substance-induced psychotic disorder is any psychotic episode that is related to the abuse of an intoxicant. Prominent psychotic symptoms are hallucinations and/or delusions. This can be the result of substance use, abuse, intoxication, or withdrawal. The speed of onset and the type of psychotic symptoms vary depending on the type of substance. Regarding symptomatology, auditory hallucinations (specifically, hearing voices), visual hallucinations, and tactile hallucinations are most common in an alcohol-induced psychotic disorder, whereas persecutory delusions and tactile hallucinations (especially formication) are commonly seen in a cocaine- or amphetamine-induced psychotic disorder.
Published: 2018
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25. Chronic Hallucinatory Disorder 'an Equivalent' of Delusional Disorder

Author: Chiara Rovera, Massimo C. Mauri, Alfredo Carlo Altamura, Giorgio Marotta, Silvia Paletta, and Chiara Di Pace
Subjects: medicine.medical_specialty, business.industry, Delusional disorder, Schizophrenia, Chronic hallucinatory psychosis, Medicine, Disease, business, medicine.disease, Psychiatry
Abstract: Chronic hallucinatory psychosis is a disease that has long been considered in the French literature, but it is neglected by the current Anglo-Saxon classification systems, which generally relegate it among the atypical forms of Schizophrenia.
Published: 2018
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26. Suicide attempts in schizophrenic patients: Clinical variables

Author: Alfredo Carlo Altamura, Massimo C. Mauri, Michele Maffini, Silvia Paletta, and D. Moliterno
Subjects: Adult, Male, medicine.medical_specialty, Poison control, Suicide, Attempted, Suicide prevention, Young Adult, medicine, Humans, Age of Onset, Psychiatry, Prospective cohort study, Suicidal ideation, General Psychology, Aged, Retrospective Studies, Depressive Disorder, Suicide attempt, Retrospective cohort study, General Medicine, Middle Aged, medicine.disease, Antidepressive Agents, Psychiatry and Mental health, Psychotic Disorders, Socioeconomic Factors, Schizophrenia, dup, Regression Analysis, Female, Schizophrenic Psychology, medicine.symptom, Psychology, Antipsychotic Agents, Clinical psychology
Abstract: Schizophrenia is associated with a significant risk of suicide: 40-50% of schizophrenic patients report suicidal ideation at some point in their lives, and 4-13% eventually commit suicide. In order to be able to predict and prevent suicide in schizophrenic patients, it is necessary to investigate and characterise suicide victims who meet the criteria for psychotic disorders and risk factors.The aim of this retrospective study was to verify the associations between suicide attempts (SAs) and the demographic and clinical variables of 106 patients who met the DSM-IV-TR criteria for schizophrenia. The patients were divided into two groups on the basis of the presence/absence of lifetime suicide attempts, and their main demographic and clinical characteristics were analysed and compared.The patients with a history of SAs frequently had a duration of untreated psychosis (DUP) of ≥1 year (chi-squared test=9.984, df=1, p=0.0016). They also showed significant associations with the presence of a depressive dimension (chi-squared test=4.439, df=1, p=0.0351), hospitalisations before SAs (chi-squared test=25.515, df=1, p0.001), and a family history of psychiatric disorders (chi-squared test=12.668, df=2, p=0.0018) or suicidal behaviours (chi-squared test=18.241, df=2, p=0.0001). Finally, they were more frequently prescribed typical antipsychotic agents.The severity of psychiatric symptoms indicates a high risk of suicide in schizophrenic patients. Further prospective studies of larger samples should investigate the role of early interventions and atypical antipsychotic treatment in reducing the risk.
Published: 2013
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27. Suppression of TNF-alpha expression, inhibition of Th1 activity, and amelioration of collagen-induced arthritis by rolipram

Author: S E Ross, R O Williams, L J Mason, C Mauri, L Marinova-Mutafchieva, A M Malfait, R N Maini, and M Feldmann
Subjects: Immunology, Immunology and Allergy
Abstract: Rolipram is a type IV phosphodiesterase inhibitor that suppresses inflammation and TNF-alpha production. As anti-TNF-alpha therapy is effective in rheumatoid arthritis, we investigated the effect of rolipram on collagen-induced arthritis (CIA), a murine model of rheumatoid arthritis. Rolipram was administered after the onset of clinical arthritis at doses of 0.5, 3, 5, or 10 mg/kg twice daily, with a dose-dependent therapeutic effect on clinical severity and joint erosion. Immunohistochemical analysis of joints of rolipram-treated mice revealed 67% reduction in TNF-alpha-expressing cells compared with control arthritic mice. In vitro studies using bone marrow-derived macrophages confirmed that rolipram directly suppressed TNF-alpha and IL-12 production following stimulation with IFN-gamma and LPS. The effect of rolipram on T cell activity was studied by measuring Th1/Th2 cytokine production by collagen-stimulated draining lymph node cells from arthritic mice treated in vivo with rolipram. Rolipram reduced IFN-gamma production and increased IL-10, indicating that rolipram down-regulated the ongoing Th1 response to type II collagen. Finally, the effect on CIA of combination therapy was studied using rolipram plus either anti-TNF-alpha or anti-CD4 mAbs. Rolipram plus anti-TNF-alpha was not therapeutically additive, whereas rolipram plus anti-CD4 mAb was clearly additive. This result indicates that the therapeutic effects of rolipram overlap with TNF-alpha blockade, but are complementary to anti-CD4 treatment. It is therefore proposed that a major mechanism of action of rolipram in CIA is suppression of TNF-alpha activity. These findings suggest that type IV phosphodiesterase inhibitors may be effective in pathologic conditions, such as RA, with overexpression of TNF-alpha.
Published: 2016

28. Poster session 3

Author: O. Nanka, E. Krejci, Z. Pesevski, D. Sedmera, N. Smart, A. Rossdeutsch, K. N. Dube, J. Riegler, A. N. Price, A. Taylor, V. Muthurangu, M. Turner, M. F. Lythgoe, P. R. Riley, S. Kryvorot, T. Vladimirskaya, I. Shved, M. Schwarzl, S. Seiler, S. Huber, P. Steendijk, H. Maechler, M. Truschnig-Wilders, B. Pieske, H. Post, C. Caprio, A. Baldini, E. Chiavacci, L. Dolfi, L. Verduci, F. Meghini, F. Cremisi, L. Pitto, T.-C. Kuan, M.-C. Chen, T.-H. Yang, W.-T. Wu, C. S. Lin, H. Rai, S. Kumar, A. K. Sharma, S. Mastana, A. Kapoor, C. M. Pandey, S. Agrawal, N. Sinha, E. H. Orlowska-Baranowska, G. Placha, J. Gora, R. Baranowski, E. Abramczuk, T. Hryniewiecki, Z. Gaciong, J. J. W. Verschuren, J. A. M. Wessels, S. Trompet, D. J. Stott, N. Sattar, B. Buckley, H. J. Guchelaar, J. W. Jukema, M. Gharanei, A. Hussain, C. J. Mee, H. L. Maddock, W. J. Wijnen, S. Van Den Oever, I. Van Der Made, M. Hiller, A. J. Tijsen, Y. M. Pinto, E. E. Creemers, S. U. Y. Nikulina, A. Chernova, A. Petry, T. Rzymski, D. Kracun, F. Riess, L. Pike, A. L. Harris, A. Gorlach, R. Katare, A. Oikawa, F. Riu, A. P. Beltrami, D. Cesseli, C. Emanueli, P. Madeddu, T. Zaglia, G. Milan, M. Franzoso, P. Pesce, C. Sarais, M. Sandri, M. Mongillo, T. J. Butler, A.-M. L. Seymour, D. Ashford, F. Jaffre, M. Bussen, I. Flohrschutz, G. R. Martin, S. Engelhardt, G. Kararigas, B. T. Nguyen, H. Jarry, V. Regitz-Zagrosek, M. Van Bilsen, A. Daniels, C. Munts, B. J. A. Janssen, G. J. Van Der Vusse, F. A. Van Nieuwenhoven, C. Montalvo, A. V. Villar, D. Merino, R. Garcia, M. Llano, M. Ares, M. A. Hurle, J. F. Nistal, A. Dembinska-Kiec, B. K. W. Beata Kiec-Wilk, A. P. Anna Polus, U. C. Urszula Czech, T. K. Tatiana Konovaleva, G. S. Gerd Schmitz, L. Bertrand, M. Balteau, A. Timmermans, B. Viollet, K. Sakamoto, O. Feron, S. Horman, J. L. Vanoverschelde, C. Beauloye, C. De Meester, E. Martinez, R. Martin, M. Miana, R. Jurado, N. Gomez-Hurtado, M. V. Bartolome, J. A. San Roman, V. Lahera, M. L. Nieto, V. Cachofeiro, F. Rochais, R. Sturny, K. Mesbah, L. Miquerol, R. G. Kelly, S. Messaoudi, B. Gravez, A. Tarjus, V. Pelloux, J. L. Samuel, C. Delcayre, J. M. Launay, K. Clement, N. Farman, F. Jaisser, L. Hadyanto, C. Castellani, G. Vescovo, B. Ravara, R. Tavano, M. Pozzobon, P. De Coppi, E. Papini, R. Vettor, G. Thiene, A. Angelini, M. Meloni, A. Caporali, D. Cesselli, O. Fortunato, E. Avolio, R. Schindler, S. Simrick, T. Brand, N. S. Smart, A. Herman, S. Roura Ferrer, J. Rodriguez Bago, C. Soler-Botija, J. M. Pujal, C. Galvez-Monton, C. Prat-Vidal, A. Llucia-Valldeperas, J. Blanco, A. Bayes-Genis, G. Foldes, M. Maxime, N. N. Ali, M. D. Schneider, S. E. Harding, C. Reni, G. Mangialardi, A. De Pauw, B. Sekkali, A. Friart, H. Ding, A. Graffeuil, D. Catalucci, J. L. Balligand, F. Azibani, F. Tournoux, S. Schlossarek, E. Polidano, L. Fazal, R. Merval, L. Carrier, C. Chatziantoniou, B. Buyandelger, W. Linke, P. Zou, S. Kostin, C. Ku, L. Felkin, E. Birks, P. Barton, M. Sattler, R. Knoell, K. Schroder, S. Benkhoff, H. Shimokawa, O. Grisk, R. P. Brandes, I. R. Parepa, L. Mazilu, A. I. Suceveanu, A. Suceveanu, L. Rusali, L. Cojocaru, L. Matei, M. Toringhibel, E. Craiu, A. L. Pires, M. Pinho, S. Pinho, C. Sena, R. Seica, A. Leite-Moreira, F. Dabroi, S. Schiaffino, E. Kiseleva, N. Krukov, O. Nikitin, L. Ardatova, I. Mourouzis, C. Pantos, A. D. Kokkinos, D. V. Cokkinos, E. Scoditti, M. Massaro, M. A. Carluccio, M. Pellegrino, N. Calabriso, A. Gastaldelli, C. Storelli, R. De Caterina, D. Lindner, C. Zietsch, H.-P. Schultheiss, C. Tschope, D. Westermann, B. R. Everaert, V. J. Nijenhuis, F. C. M. Reith, V. Y. Hoymans, J. P. Timmermans, C. J. Vrints, I. Simova, H. Mateev, T. Katova, L. Haralanov, N. Dimitrov, N. Mironov, S. P. Golitsyn, S. F. Sokolov, Y. U. A. Yuricheva, E. B. Maikov, N. B. Shlevkov, L. V. Rosenstraukh, E. I. Chazov, J. Radosinska, V. Knezl, T. Benova, J. Slezak, L. Urban, N. Tribulova, L. Virag, A. Kristof, Z. S. Kohajda, T. Szel, Z. Husti, I. Baczko, N. Jost, A. Varro, A. Sarusi, A. S. Farkas, S. Z. Orosz, T. Forster, A. Farkas, O. M. Zakhrabova-Zwiauer, M. Hardziyenka, R. Nieuwland, H. L. Tan, A. J. A. Raaijmakers, V. J. A. Bourgonje, G. J. M. Kok, A. A. B. Van Veen, M. E. Anderson, M. A. Vos, M. F. A. Bierhuizen, J. Benes, B. Sebestova, I. A. Ghouri, O. J. Kemi, A. Kelly, F. L. Burton, G. L. Smith, S. Ozdemir, K. Acsai, N. Doisne, R. Van Der Nagel, H. D. M. Beekman, T. A. B. Van Veen, K. R. Sipido, G. Antoons, S. C. Harmer, J. S. Mohal, D. Kemp, A. Tinker, D. Beech, D. S. Burley, C. D. Cox, K. T. Wann, G. F. Baxter, R. Wilders, A. Verkerk, P. Fragkiadaki, G. Germanakis, K. Tsarouchas, C. Tsitsimpikou, M. Tsardi, D. George, A. Tsatsakis, P. Rodrigues, C. Barros, A. K. Najmi, V. Khan, M. Akhtar, K. K. Pillai, M. Mujeeb, M. Aqil, C. R. Bayliss, A. E. Messer, M.-C. Leung, D. Ward, J. Van Der Velden, C. Poggesi, C. S. Redwood, S. Marston, A. Vite, E. Gandjbakhch, F. Gary, V. Fressart, P. Leprince, G. Fontaine, M. Komajda, P. Charron, E. Villard, I. Falcao-Pires, C. Gavina, N. Hamdani, G. J. M. Stienen, H. W. M. Niessens, A. F. Leite-Moreira, W. J. Paulus, M. Memo, S. B. Marston, E. Vafiadaki, J. Qian, D. A. Arvanitis, D. Sanoudou, E. G. Kranias, N. Elmstedt, B. Lind, K. Ferm-Widlund, M. Westgren, L.-A. Brodin, C. Mansfield, T. West, M. Ferenczi, P. J. M. Wijnker, D. B. Foster, A. Coulter, A. Frazier, A. M. Murphy, M. Shah, M. B. Sikkel, T. Desplantez, T. P. Collins, P. O' Gara, A. R. Lyon, K. T. Macleod, A. H. Ottesen, W. E. Louch, C. Carlson, O. J. B. Landsverk, M. Stridsberg, I. Sjaastad, E. Oie, T. Omland, G. Christensen, H. Rosjo, J. Cartledge, L. A. Clark, M. Ibrahim, U. Siedlecka, M. Navaratnarajah, M. H. Yacoub, P. Camelliti, C. M. Terracciano, A. Chester, A. Gonzalez-Tendero, I. Torre, F. Garcia-Garcia, J. Dopazo, E. Gratacos, D. Taylor, S. Bhandari, A.-M. Seymour, D. Fliegner, J. Jost, H. Bugger, R. Ventura-Clapier, A. Carpi, M. Campesan, M. Canton, R. Menabo, P. G. Pelicci, M. Giorgio, F. Di Lisa, M. Hancock, A. Venturini, N. Al-Shanti, C. Stewart, R. Ascione, G. Angelini, M.-S. Suleiman, E. Kravchuk, E. Grineva, M. Galagudza, A. Kostareva, A. Bairamov, K. A. Krychtiuk, L. Watzke, C. Kaun, S. Demyanets, J. Pisoni, S. P. Kastl, K. Huber, G. Maurer, J. Wojta, W. S. Speidl, Z. V. Varga, N. Farago, A. Zvara, G. F. Kocsis, M. Pipicz, C. Csonka, T. Csont, G. L. Puskas, P. Ferdinandy, M. Klevstigova, J. Silhavy, D. Manakov, F. Papousek, J. Novotny, M. Pravenec, F. Kolar, O. Novakova, F. Novak, J. Neckar, J. Barallobre-Barreiro, A. Didangelos, X. Yin, M. Fernandez-Caggiano, I. Drozdov, P. Willeit, N. Domenech, M. Mayr, S. Lemoine, S. Allouche, L. Coulbault, P. Galera, J. L. Gerard, J. L. Hanouz, E. Suveren, M. Whiteman, I. M. Studneva, O. Pisarenko, V. Shulzhenko, L. Serebryakova, O. Tskitishvili, A. Timoshin, J. Fauconnier, A. C. Meli, J. Thireau, S. Roberge, A. M. Lompre, E. Jacotot, A. M. Marks, A. Lacampagne, B. Dietel, R. Altendorf, W. G. Daniel, R. Kollmar, C. D. Garlichs, V. Parente, S. Balasso, G. Pompilio, G. Colombo, G. Milano, L. Squadroni, F. Cotelli, O. Pozzoli, M. C. Capogrossi, Y. Ajiro, N. Saegusa, K. Iwade, W. R. Giles, D. M. Stafforini, K. W. Spitzer, R. Sirohi, L. Candilio, G. Babu, N. Roberts, D. Lawrence, A. Sheikh, S. Kolvekar, J. Yap, D. J. Hausenloy, D. M. Yellon, M. Aslam, S. Rohrbach, K.-D. Schlueter, H. M. Piper, T. Noll, D. Guenduez, L. Malinova, V. P. Ryabukho, D. V. Lyakin, T. P. Denisova, S. Montoro-Garcia, E. Shantsila, G. Y. H. Lip, B. Kalaska, E. Sokolowska, K. Kaminski, K. Szczubialka, K. Kramkowski, A. Mogielnicki, M. Nowakowska, W. Buczko, N. Stancheva, E. Mekenyan, K. Gospodinov, S. Tisheva, A. Darago, I. Rutkai, J. Kalasz, A. Czikora, P. Orosz, H. D. Bjornson, I. Edes, Z. Papp, A. Toth, K. Riches, P. Warburton, D. J. O'regan, S. G. Ball, N. A. Turner, I. C. Wood, K. E. Porter, S. Kogaki, H. Ishida, N. Nawa, K. Takahashi, H. Baden, H. Ichimori, T. Uchikawa, S. Mihara, K. Miura, K. Ozono, R. Lugano, T. Padro, M. Garcia-Arguinzonis, L. Badimon, F. Ferraro, R. Viner, J. Ho, D. Cutler, V. Matchkov, C. Aalkjaer, P. A. J. Krijnen, N. E. Hahn, I. Kholova, J. A. Sipkens, F. P. Van Alphen, S. Simsek, C. G. Schalkwijk, J. D. Van Buul, V. W. M. Van Hinsbergh, H. W. M. Niessen, C. G. Caro, A. Seneviratne, C. Monaco, D. Hou, J. Singh, P. Gilson, M. G. Burke, K. B. Heraty, R. Krams, G. Coppola, K. Albrecht, W. Schgoer, D. Wiedemann, N. Bonaros, C. Steger, M. Theurl, U. Stanzl, R. Kirchmair, S. Amadesi, G. Spinetti, E. Cangiano, M. Valgimigli, A. M. Miller, A. Cardinali, K. Vierlinger, G. Pagano, D. Liccardo, C. Zincarelli, G. D. Femminella, A. Lymperopoulos, C. De Lucia, W. J. Koch, D. Leosco, G. Rengo, R. Hinkel, W. Husada, T. Trenkwalder, Q. Di, S. Lee, B. Petersen, I. Bock-Marquette, H. Niemann, M. Di Maio, C. Kupatt, M. Nourian, Z. Yassin, R. Kelishadi, S. H. Memarian, A. Heidari, A. Leuner, D. M. Poitz, C. Brunssen, U. Ravens, R. H. Strasser, H. Morawietz, F. Vogt, A. Grahl, C. Flege, N. Marx, M. Borinski, B. De Geest, F. Jacobs, I. Muthuramu, S. C. Gordts, E. Van Craeyveld, P. Herijgers, S. Weinert, S. Medunjanin, J. Herold, A. Schmeisser, R. C. Braun-Dullaeus, A. H. Wagner, K. Moeller, O. Adolph, M. Schwarz, C. Schwale, C. Bruehl, R. Nobiling, T. Wieland, S. W. Schneider, M. Hecker, A. Cross, A. Strom, J. Cole, M. Goddard, A. Hultgardh-Nilsson, J. Nilsson, C. Mauri, N. P. Mitkovskaya, T. A. Kurak, E. G. Oganova, E. I. Shkrebneva, Z. H. N. Kot, T. V. Statkevich, F. Molica, F. Burger, C. M. Matter, A. Thomas, C. Staub, A. Zimmer, B. Cravatt, P. Pacher, S. Steffens, R. Blanco, R. Sarmiento, C. Parisi, S. Fandino, F. Blanco, G. Gigena, J. Szarfer, A. Rodriguez, A. Garcia Escudero, M. A. Riccitelli, S. Wantha, S. Simsekyilmaz, R. T. Megens, M. A. Van Zandvoort, E. Liehn, A. Zernecke, D. Klee, C. Weber, O. Soehnlein, L. M. Lima, M. G. Carvalho, K. B. Gomes, I. R. Santos, M. O. Sousa, C. A. S. Morais, S. H. V. Oliveira, I. F. Gomes, F. C. Brandao, M. R. A. Lamego, L. Fornai, A. Kiss, F. Giskes, G. Eijkel, M. Fedrigo, M. L. Valente, R. M. A. Heeren, A. Grdinic, D. Vojvodic, N. Djukanovic, A. G. Grdinic, S. Obradovic, I. Majstorovic, S. Rusovic, Z. Vucinic, D. Tavciovski, M. Ostojic, S.-C. Lai, M.-Y. Chen, H.-T. Wu, L. Gouweleeuw, S. U. Oberdorf-Maass, R. A. De Boer, W. H. Van Gilst, A. H. Maass, I. C. Van Gelder, L. Benard, C. Li, D. Warren, C. M. Shanahan, Q. P. Zhang, A. Bye, R. Vettukattil, S. T. Aspenes, G. Giskeodegaard, I. S. Gribbestad, U. Wisloff, T. F. Bathen, J. Cubedo, R. Alonso, P. Mata, I. Ivic, Z. Vamos, P. Cseplo, D. Kosa, O. Torok, J. Hamar, A. Koller, K. Norita, S. V. De Noronha, M. N. Sheppard, I. Amat-Roldan, I. Iruretagoiena, S. Psilodimitrakopoulos, F. Crispi, D. Artigas, P. Loza-Alvarez, J. C. Harrison, S. D. Smart, E. H. Besely, J. R. Kelly, Y. Yao, I. A. Sammut, M. Hoepfner, W. Kuzyniak, E. Sekhosana, B. Hoffmann, C. Litwinski, A. Pries, E. Ermilov, D. Fontoura, A. P. Lourenco, F. Vasques-Novoa, J. P. Pinto, R. Roncon-Albuquerque, I. P. Oyeyipo, L. A. Olatunji, T. O. Usman, V. A. Olatunji, B. Bacova, C. Viczenczova, V. Dosenko, E. Goncalvesova, J. Vanrooyen, S. K. Maulik, S. Seth, A. K. Dinda, A. Jaiswal, G. Mearini, D. Khajetoorians, E. Kraemer, C. Gedicke-Hornung, G. Precigout, T. Eschenhagen, T. Voit, L. Garcia, S. Lorain, P. Mendes-Ferreira, C. Maia-Rocha, R. Adao, R. J. Cerqueira, M. J. Mendes, P. Castro-Chaves, G. W. De Keulenaer, C. Bras-Silva, G. Ruiter, Y. Y. Wong, M. Lubberink, P. Knaapen, P. Raijmakers, A. A. Lammertsma, J. T. Marcus, N. Westerhof, W. J. Van Der Laarse, A. Vonk-Noordegraaf, N. Steinbronn, E. Koch, G. Steiner, A. Berezin, O. A. Lisovaya, A. M. Soldatova, V. A. Kuznetcov, T. N. Yenina, A. Y. U. Rychkov, P. V. Shebeko, R. Altara, M. H. M. Hessel, J. J. R. Hermans, W. M. Blankesteijn, T. A. Berezina, V. Seden, C. Bonanad, J. Nunez, D. Navarro, M. F. Chilet, F. Sanchis, V. Bodi, G. Minana, F. Chaustre, M. J. Forteza, A. Llacer, G. Galasso, N. Ferrara, A. Akhmedov, R. Klingenberg, C. Brokopp, D. Hof, S. Zoller, R. Corti, S. Gay, A. Von Eckardstein, S. P. Hoerstrup, T. F. Luescher, J. Heijman, A. Zaza, D. M. Johnson, Y. Rudy, R. L. M. Peeters, P. G. A. Volders, R. L. Westra, S. Fujita, R. Okamoto, M. Taniguchi, K. Konishi, I. Goto, K. Sugimoto, M. Nakamura, K. Shiraki, C. Buechler, and M. Ito
Subjects: AMP-activated protein kinase, biology, Physiology, Chemistry, Physiology (medical), Mesenchymal stem cell, biology.protein, Cardiology and Cardiovascular Medicine, Cell biology
Published: 2012
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29. Effect of Quetiapine and Norquetiapine on Anxiety and Depression in Major Psychoses Using a Pharmacokinetic Approach

Author: Massimo C. Mauri, D. Moliterno, Massimiliano Buoli, Silvia Paletta, A. Carlo Altamura, Bernardo Dell'Osso, and Silvio R. Bareggi
Subjects: Adult, Male, Dibenzothiazepines, medicine.medical_specialty, medicine.medical_treatment, Anxiety, Quetiapine Fumarate, Internal medicine, medicine, Humans, Pharmacology (medical), Prospective Studies, Antipsychotic, Psychiatry, Borderline personality disorder, Depression (differential diagnoses), Depression, business.industry, General Medicine, Middle Aged, medicine.disease, Psychotic Disorders, Schizophrenia, Antidepressant, Quetiapine, Female, medicine.symptom, business, Antipsychotic Agents, medicine.drug
Abstract: Background: Quetiapine apparently differs from other antipsychotic drugs in terms of its antidepressant activity and efficacy in bipolar depression. The mechanism of this activity is unknown although it may be mediated by its metabolite N-desalkylquetiapine (norquetiapine). Objective: The aim of the study was to analyse the relationships between quetiapine and norquetiapine plasma concentrations and clinical improvement in depressive and anxious symptoms. Methods: This was a prospective observational study. Recruited patients were evaluated during a clinical post-acute phase. Patients were recruited from patients hospitalized in the Psychiatric Department of Ospedale Maggiore Policlinico of Milan, Italy. After discharge they were followed-up as outpatients. The study involved 41 outpatients (23 males, 18 females; age >18 years) diagnosed as affected by schizophrenia (17 patients), borderline personality disorder (eight patients) or bipolar depression (16 patients) on the basis of the Diagnostic and Statistical Manual of Mental Disorders, fourth text revision (DSM-IV-TR) criteria. Patients were prescribed 50–800 mg of quetiapine (Seroquel®). Patients were evaluated after discharge from the psychiatric department (baseline, T0), after 15 days (T1) and after 3 months (T2) using the Brief Psychiatry Rating Scale (BPRS) with particular reference to the dimensions of depression (items 5, 9 and 13) and anxiety (items 1, 2 and 6). Plasma quetiapine and norquetiapine concentrations were determined by means of high-performance liquid chromatography at T2. Results: There was a significant improvement in the mean BPRS total score, as well as in the dimensions of anxiety and depression. The bipolar patients only showed a significant curvilinear relationship described by a second-order polynomial model between the plasma norquetiapine/quetiapine concentration ratio and the improvement in depression at T2. There was a significant negative linear correlation between the norquetiapine/quetiapine ratio and anxiety in all of the patients. Conclusion: The results of this study confirm the efficacy of quetiapine on both anxious and depressive symptoms. Norquetiapine has a specific effect on anxiety and depressive symptoms, showing a correlation between plasma concentrations and clinical efficacy only in patients with bipolar depression.
Published: 2012
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30. Perfectionism in depression, obsessive-compulsive disorder and eating disorders

Author: Sandra Sassaroli, Leonor J. Romero Lauro, Piergiuseppe Vinai, Massimo C. Mauri, Randy O. Frost, Giovanni Maria Ruggiero, Sassaroli, S, Romero Lauro, L, Maria Ruggiero, G, Mauri, M, Vinai, P, and Frost, R
Subjects: Adult, Male, Obsessive-Compulsive Disorder, medicine.medical_specialty, Compulsive Personality Disorder, medicine.medical_treatment, Experimental and Cognitive Psychology, Personal Satisfaction, medicine.disease_cause, Feeding and Eating Disorders, medicine, Feeding and Eating Disorder, Humans, Psychiatry, Depression (differential diagnoses), Psychiatric Status Rating Scales, Analysis of Variance, Cognitive Behavioral Therapy, Depression, Eating disorder, Perfectionism (psychology), Psychiatric Status Rating Scale, medicine.disease, Anxiety Disorders, Self Concept, Cognitive behavioral therapy, Psychiatry and Mental health, Clinical Psychology, Eating disorders, Case-Control Studies, Anxiety, Female, Perfectionism, medicine.symptom, Case-Control Studie, Psychology, Anxiety Disorder, Anxiety disorder, Human, Psychopathology, Clinical psychology
Abstract: High levels of perfectionism have been observed in major depression, anxiety disorders and eating disorders. Though few studies have compared levels of perfectionism across these disorders, there is reason to believe that different dimensions of perfectionism may be involved in eating disorders than in depression or anxiety [Bardone-Cone, A. M. et al. (2007). Perfectionism and eating disorders: Current status and future directions. Clinical Psychology Review, 27, 84-405]. The present study compared patients with major depression, obsessive-compulsive disorder, and eating disorders on dimensions of perfectionism. Concern over Mistakes was elevated in each of the patient groups while Pure Personal Standards was only elevated in the eating disorder sample. Doubts about Actions was elevated in both patients with obsessive-compulsive disorder and eating disorders, but not in depressed patients. Analyses of covariance indicated that Concern over Mistakes accounted for most of the variance in the relationship of perfectionism to these forms of psychopathology. © 2008 Elsevier Ltd. All rights reserved.
Published: 2008
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31. Depression in schizophrenia: Comparison of first- and second-generation antipsychotic drugs

Author: D. Moliterno, Alessandro Colasanti, Massimo C. Mauri, and M. Rossattini
Subjects: Adult, Male, Olanzapine, medicine.medical_specialty, medicine.drug_class, medicine.medical_treatment, Atypical antipsychotic, Sex Factors, Recurrence, Brief Psychiatric Rating Scale, medicine, Haloperidol, Humans, Fluphenazine Decanoate, Antipsychotic, Psychiatry, Biological Psychiatry, Retrospective Studies, Neurologic Examination, Psychiatric Status Rating Scales, Risperidone, Depression, Middle Aged, Affect, Psychiatry and Mental health, Treatment Outcome, Delayed-Action Preparations, Schizophrenia, Quetiapine, Female, Schizophrenic Psychology, Psychology, Antipsychotic Agents, medicine.drug, Clinical psychology
Abstract: The aim of this study was to compare the effects of different antipsychotics on depressive symptoms in schizophrenic patients. The data were drawn from a retrospective, naturalistic, observational study in which 222 subjects diagnosed as being affected by schizophrenia during a re-exacerbation phase received 6 weeks of monotherapy with fluphenazine decanoate, haloperidol decanoate, haloperidol, clozapine, olanzapine, quetiapine, risperidone or l-sulpiride. The Brief Psychiatric Rating Scale (BPRS), Extrapyramidal Side Effects Rating Scale (EPSE) and Anticholinergic Rating Scale (ACS) were administered at baseline and six weeks after the beginning of the study; depressive symptoms were evaluated using the BPRS items "depressive mood" and "guilt feelings". All of the antipsychotic drugs led to improvements in the depressive dimension, but this was statistically significant only in the case of fluphenazine decanoate, haloperidol, olanzapine, risperidone and l-sulpiride. A clinical improvement in the depressive dimension significantly correlated with the severity of the psychotic picture and its amelioration. Female patients were significantly more likely to show an improvement in depressive symptoms. In conclusion, our findings suggest that atypical antipsychotics as a class do not seem to be more effective on the depressive dimension during the course of schizophrenia than typical ones, at least as far as the collected BPRS data are concerned. The only factor that seemed to influence the improvement in depressive symptoms during our study was gender, as females were significantly more likely to improve although there were no between-gender differences in the baseline severity of the clinical picture.
Published: 2008
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32. Second Generation Antipsychotics in the Treatment of Major Depression

Author: C. Mauri Massimo
Subjects: World Wide Web, medicine.medical_specialty, business.industry, Open access publishing, medicine, Alternative medicine, Dual diagnosis, Psychiatry, business, Depression (differential diagnoses)
Published: 2016
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33. Drug Induced Psychosis or Schizophrenia?

Author: Massimo C. Mauri
Subjects: Hallucinogen, medicine.medical_specialty, Drug induced psychosis, biology, business.industry, Disease, Pharmacology, Psychotomimetic, medicine.disease, biology.organism_classification, Open access publishing, Schizophrenia, Cocaine use, Medicine, Cannabis, business, Psychiatry, medicine.drug
Abstract: Cannabis, cocaine, amphetamines and derivative substances so as hallucinogens and other drugs with psychotomimetic properties has reached an extensive misuse often producing psychotic reactions similar to primary psychotic disease like schizophrenia. In particular cannabis and cocaine use by young people has been increased during these years, and the age of first use is dramatically decreased [1,2].
Published: 2016
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34. Emerging Trends and Prevalences in Dual Diagnosis

Author: Massimo C. Mauri
Subjects: Substance abuse, medicine.medical_specialty, Open access publishing, business.industry, Schizophrenia (object-oriented programming), Family medicine, Alternative medicine, medicine, Library science, Dual diagnosis, Editorial board, medicine.disease, business
Abstract: Dear colleagues: I am very proud to be invited to join as Editorial Board for Dual Diagnosis: Open Access. It is a very interesting journal with an aim to provide rapid and reliable source of information in the mode of original articles, review articles, case reports, and short communications. This scientific publishes all relevant topics in the area of dual diagnosis particularly, Dual Diagnosis, clinical and treatment. The title of Journal is intriguing and topical. The link between substance abuse and psychosis including schizophrenia itself is debated among clinicians, pharmacologists, and it has important social implications.
Published: 2016
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35. Predictors of Clinical Outcome in Schizophrenic Patients Responding to Clozapine

Author: Bernardo Dell'Osso, Massimo C. Mauri, L.S. Volonteri, Pietro Papa, Marialuisa Baldi, Francesca Regispani, and Silvio R. Bareggi
Subjects: Adult, Male, medicine.medical_specialty, Severity of Illness Index, Gastroenterology, Leukocyte Count, Sex Factors, Predictive Value of Tests, Internal medicine, Brief Psychiatric Rating Scale, Severity of illness, medicine, Humans, Pharmacology (medical), Psychiatry, Clozapine, Scale for the Assessment of Negative Symptoms, Middle Aged, Psychiatry and Mental health, Treatment Outcome, Predictive value of tests, Pharmacodynamics, Schizophrenia, Female, Psychology, Pharmacogenetics, Antipsychotic Agents, Psychopathology, medicine.drug
Abstract: Many of the patients who respond better to clozapine (CLZ) than to typical antipsychotics still have residual psychopathology, but CLZ drug resistance data are lacking. The aim of this study was to evaluate the possible predictive factors of a clinical response to CLZ in a group of 20 schizophrenic patients (DSM-IV: 13 males and 7 females with a mean age of 35.5 years +/- 7.1 SD) resistant to typical antipsychotics but CLZ responders as assessed by the Brief Psychiatric Rating Scale (BPRS) (20% improvement). After a 1-week washout period, CLZ was started at a dose of 25 mg/d, which was increased by the third week up to a maximum of 600 mg/d (mean 365.00 +/- 129.88 mg/d SD) and remained unchanged until the end of the study (week 8). The patients showed a significant improvement in the mean scores of the rating scales for positive (SAPS) and negative symptoms of schizophrenia (Scale for the Assessment of Negative Symptoms, SANS) (P0.003, P0.02). All of the patients included in the study were BPRS responders; 65% were also SAPS and 75% SANS responders (20% improvement). The improvement in the SANS score was significantly greater among the female patients (P0.05). The SAPS and SANS responders had a significantly higher mean metabolic ratio [MR = (NCLZ/CLZ)] than the nonresponders (P0.01), and the percentage of improvement significantly correlated with the increase in MR. This finding suggests that the individual pharmacogenetics indicated by metabolic capacity may be related to clinical response. All of the patients showed a reduction in white blood cell counts, but this was significantly less in the SANS responders than the SANS nonresponders (P = 0.047). The SAPS responders had significantly lower neutrophil counts than the nonresponders (P = 0.03). Our results seem to suggest the importance of pharmacodynamic, constitutional, and genetic data over strict pharmacokinetics in determining the clinical response to CLZ.
Published: 2003
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36. Clinical outcome and tolerability of sertraline in major depression

Author: Sergio Manfré, V. Laini, Massimo C. Mauri, G. Panza, Francesca Regispani, Marta E. Scalvini, L. Boscati, Lara Malvini, L.S. Volonteri, and Giancarlo Cerveri
Subjects: Pharmacology, Sertraline, medicine.medical_specialty, book.periodical, Nausea, Hamilton Rating Scale for Depression, medicine.disease, Tolerability, Cephalalgia, Rating scale, Internal medicine, Anesthesia, Brief Psychiatric Rating Scale, medicine, Major depressive disorder, medicine.symptom, Psychology, book, Biological Psychiatry, medicine.drug
Abstract: Sertraline (SRT) has been shown to be an effective antidepressant in extensive clinical trial programs but data on plasma concentrations regarding clinical outcome and tolerability are lacking. Twenty-one out-patients of both sexes, with mean age of 50.23 years (S.D. = 17.37), affected by major depressive disorder, recurrent (Diagnostic and Statistical Manual of Mental Disorder--IV, DSM-IV), were treated with 25-150 mg of SRT once a day (mean=66.26 mg, S.D.=30.50) for 30 days. Clinical evaluation was assessed at baseline (T0), after 15 days (T15), and then after 30 days (T30). Plasma samples for SRT level determination were collected at T30. Brief Psychiatric Rating Scale (BPRS), Hamilton Rating Scale for Depression (HRS-D), and Hamilton Rating Scale for Anxiety (HRS-A) showed a significant improvement during the study (P
Published: 2002
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37. Uso de la farmacogenética como herramienta de precisión en psiquiatría: hacia una medicina personalizada

Author: N. Ana María Wielandt, C. Mauricio Moreno, and L. Lina Ortiz
Subjects: Pharmacogenetics, Pharmacogenomic Variants, Personalized Medicine, Mental Disorders, Genetic Polymorphisms, Cytochrome P450 Enzyme System., Medicine
Abstract: Resumen: A nivel mundial, los problemas de salud mental constituyen una carga de enfermedad importante. En Chile, la depresión ocupa el primer lugar en la carga de enfermedad debida a trastornos mentales; según datos de la Encuesta Nacional de Salud 2016-2017 realizada por el Ministerio de Salud, un 15,8% de la población mayores de 18 años presentan depresión según la definición que emplea el CIDI (Composite International Diagnostic Interview) desarrollado por la OMS para estudios de salud mental. Uno de los principales desafíos que enfrenta la psiquiatría actualmente, es poder mejorar el enfoque de prueba y error para el tratamiento farmacológico de la enfermedad mental, puesto que uno de los problemas más importantes es la falta de respuesta al tratamiento (20-30% de los pacientes), sumado a la falta de adherencia al tratamiento y la presencia de reacciones adversas a las drogas.Dados los avances en la secuenciación del genoma humano, se ha podido establecer que uno de los factores que influyen en el metabolismo de las drogas usadas en pacientes psiquiátricos es la presencia de polimorfismos que afectan distintos genes que modulan la farmacocinética o la farmacodinamia de los fármacos. De ahí que en los últimos años los centros de salud más importantes del mundo realizan estudios de farmacogenética a sus pacientes con el fin de entregarles la mejor terapia de acuerdo con sus características individualesEn este trabajo se presenta una actualización de este tema y, conjuntamente, se comenta la experiencia en Clínica Las Condes de la caracterización realizada en un estudio previo en pacientes que consultan principalmente por trastornos psiquiátricos como cuadros ansiosos y depresivos. Dicho estudio incluyó las variantes genómicas de un grupo de 6 genes pertenecientes a la familia del Citocromo P450 (CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A4 y CYP3A5), responsables en gran medida del metabolismo de la mayoría de las drogas usadas en psiquiatría. Con esta información se ha podido implementar una terapia farmacológica dirigida a cada paciente con el fin de lograr una mejor respuesta terapéutica Summary: Globally, mental health problems constitute a significant disease burden. In Chile, depression ranks first in the burden of disease due to mental disorders, according to data from the 2016-2017 National HealthSurvey conducted by the Ministry of Health, 15,8% of the population over 18 years old present depression according to the definition used by CIDI (Composite International Diagnostic Interview) developed by the WHO for mental health studies. One of the main challenges facing psychiatry today is to improve the trial-and-error approach for the pharmacological treatment of mental illness since one of the most important problems is the lack of response to treatment (20-30% of patients), in addition to the lack of treatment adherence and the presence of adverse drug reactions.Given the advances in the sequencing of the human genome, it has been established that one of the factors that influence the metabolism of drugs used in psychiatric patients is the presence of polymorphisms that affect different genes that modulate the pharmacokinetics or pharmacodynamics of drugs. Hence, in recent years the most important health centers in the world carry out pharmacogenetic studies on their patients to deliver the best therapy according to their individual characteristics.In this review, we present an update on this topic and also comment Clínica Las Condes’ experience in the implementation of a pharmacogenetic study for patients consulting for psychiatric disorders, mainly anxiety and depression, which analyzed the genomic variants of a group of 6 genes belonging to the cytochrome P450 family (CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A4, and CYP3A5), largely responsible for the metabolism of most drugs used in psychiatry. With this information, it has been possible to implement a pharmacological therapy directed at each patient to achieve a better therapeutic response.
Published: 2022
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38. Dosing patterns in Europe: Efficacy and safety of risperidone long-acting injectable in doses of 25, 37.5 and 50 mg

Author: L.S. Volonteri, Massimo C. Mauri, Rossella Medori, Wolfgang Maier, and Martin Turner
Subjects: medicine.medical_specialty, Risperidone, Positive and Negative Syndrome Scale, business.industry, medicine.medical_treatment, Microsphere, Psychiatry and Mental health, Long acting, Anesthesia, medicine, In patient, Dosing, Adverse effect, Antipsychotic, business, Psychiatry, medicine.drug
Abstract: Objective. To assess the dose prescription patterns for risperidone long-acting injectable (RLAI) in patients with schizophrenia who participated in the 6-month, open-label Switch to Risperidone Microspheres (StoRMi) trial. Methods. Clinically stable patients requiring a change in medication were converted to RLAI prescribed using clinically-appropriate doses, as determined by treating clinicians. RLAI 25 mg was recommended as the starting dose, although higher initiation doses were permitted if deemed necessary. RLAI was administered intramuscularly every 2 weeks, with dosage adjustments permitted, and continued for a total of 6 months. Efficacy outcomes included Positive and Negative Syndrome Scale (PANSS) and Clinical Global Impression-Severity (CGI-S). Treatment-emergent adverse events (AEs) were monitored. Results. A total of 1,849 patients were included. Modal dose was 25 mg for 52.9% of patients. At baseline, patients treated with lower RLAI doses were more likely to be female, have shorter disease duration, milder symptoms, and be using less polypharmacy. The strongest predictors that a patient would remain on 25 mg RLAI were baseline PANSS hallucinatory behaviour item score (odds ratio [OR]=0.78), baseline CGI-S score (OR=0.69), female gender (OR=1.56), and country of residence (P0.001 for all). Efficacy measures improved in all dose groups, with the greatest improvement seen in patients treated with lower doses. AEs were more common in patients treated with 50 mg RLAI (68 vs. 57% with lower doses; P0.0001), although most AEs were mild to moderate in severity. Conclusion. In this study, 25 mg RLAI was the most commonly prescribed dose. RLAI was effective and well tolerated over the full range of doses.
Published: 2014

39. Rotator cuff surgery in persons with spinal cord injury: Relevance of a multidisciplinary approach

Author: B. Coulet, Jean-Luc Ducros, C. Verollet, Anthony Gelis, Charles Fattal, H. Rouays-Mabit, Jacques Teissier, and C. Mauri
Subjects: Adult, Male, Shoulder, medicine.medical_specialty, Shoulders, Quadriplegia, Imaging data, Rotator Cuff Injuries, Lesion, Rotator Cuff, Physical medicine and rehabilitation, Tendon Injuries, Multidisciplinary approach, medicine, Humans, Rotator cuff, Relevance (information retrieval), Orthopedics and Sports Medicine, Prospective Studies, Spinal cord injury, Spinal Cord Injuries, Aged, Paraplegia, Patient Care Team, Shoulder Joint, business.industry, Rehabilitation, General Medicine, Middle Aged, medicine.disease, Arthralgia, Surgery, medicine.anatomical_structure, Rotator cuff pathology, SCI, Physical therapy, Female, Functional status, medicine.symptom, business
Abstract: Background This article is a prospective review of patients with spinal cord injury who underwent multidisciplinary consultation from January 2005 to September 2013 for pain in one or both shoulders. Methods We performed clinical, functional, and lesion evaluations of 38 patients with paraplegia and quadriplegia presenting with rotator cuff pathologies. Results Surgery was indicated and performed on 38 shoulders in 28 patients. The lesion assessment during surgery showed injuries that were more severe than one would have thought based on imaging data. The mean pain intensity rating in the operative and nonoperative groups was 0 and 1.6, respectively, at rest and 2 and 4.9, respectively, during paroxysmal peaks. On average, for patients who had surgery, the Functional Independence Measure score decreased by 2.3. The mean satisfaction index in operated patients was 8.5 of 10. Conclusions When the surgical indication was based on a multidisciplinary decision, no negative results were reported that could have challenged the validity of this decision. Pain relief was the primary benefit reported after surgery. The functional status was modified because of the technical aids needed to prevent shoulder overuse. There are several arguments in favor of rotator cuff surgery for wheelchair-bound patients with spinal cord injury. Because of their functional impairments, wheelchair-bound patients will continue to overburden their shoulders after rotator cuff surgery. A multidisciplinary approach emerges as the solution to inform and educate patients to limit the risk of recurrence.
Published: 2014
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40. Tratamiento a largo plazo de la esquizofrenia crónica con risperidona: un estudio con concentraciones plasmáticas

Author: V. Salvi, P. Papa, Renata Rudelli, R. Orlandi, L. Boscati, V. Laini, and Massimo C. Mauri
Subjects: 03 medical and health sciences, 0302 clinical medicine, 05 social sciences, 050109 social psychology, 0501 psychology and cognitive sciences, 030227 psychiatry
Abstract: ResumenSe trató a 24 pacientes ambulatorios esquizofrénicos crónicos con una edad media de 37,21 años ± 9,96 DT con risperidona (RSP) en una dosis de 2-9 mg/día (media = 4,46 mg/día ± 1,30 DT, media = 0,06 mg/kg ± 0,01 DT) durante un año.La evaluación clínica se realizó con la Escala de Evaluación Psiquiátrica Breve (BPRS), la Escala de Síntomas Positivos y Negativos (PANSS), la Escala de Evaluación de los Efectos Secundarios Extrapiramidales (EPSE) y una lista para los Efectos Secundarios Anticolinérgicos (ACS) en T0 y luego después de 1 (TI), 2 (T2), 3 (T3), 6 (T6), 9 (T9) y 12 (TI2) meses. Se determinaron las concentraciones de RSP y 9-hidroxi-risperidona (9OH-RSP) en T12 por el método CLAR. Los valores medios de la BPRS y la PANSS mostraron una mejoría significativa durante el estudio. No resultó ninguna correlación entre la dosis de RSP (mg/kg) y las concentraciones plasmáticas de RSP, de 9OH-RSP o el grupo activo. Se observó una correlación positiva entre la edad y el gmpo activo y también entre las concentraciones plasmáticas de RSP y 9OH-RSP Se observó una relación curvilínea entre el grupo activo y la mejoría en la PANSS (%). Los pacientes con la mejora mayor en la PANSS mostraron concentraciones plasmáticas de RSP + 9OH-RSP de 15-30 ng/mL. La RSP parece ser un fármaco bastante efectivo. Sin embargo, parece difícil idear programas de dosis apropiados y la determinación de la concentración plasmática parece ser necesaria en algunos casos.
Published: 2001
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41. Gabapentin and the Prophylaxis of Bipolar Disorders in Patients Intolerant to Lithium

Author: Veronica Ferrari, Marta E. Scalvini, Anna Caterina Omboni, Giancarlo Cerveri, Virginio Salvi, Massimo C. Mauri, Alessandra Clemente, and V. Laini
Subjects: medicine.medical_specialty, Lithium (medication), Gabapentin, business.industry, medicine.medical_treatment, Hamilton Rating Scale for Depression, General Medicine, medicine.disease, Anticonvulsant, Tolerability, Internal medicine, Anesthesia, Brief Psychiatric Rating Scale, Medicine, Pharmacology (medical), Bipolar disorder, business, Adverse effect, medicine.drug
Abstract: Gabapentin (GBP) is a new anticonvulsant drug that has shown efficacy in the treatment of epilepsy, several neurological disorders (pain syndromes, acquired nystagmus, Huntington’s chorea, amyotrophic lateral sclerosis), and more recently in the treatment of bipolar disorders. The aim of this preliminary study was to assess the efficacy of GBP as a mood stabiliser in bipolar disorders. The adverse events of GBP were also evaluated. 21 outpatients, 13 females and 8 males (mean age ± SD: 51.90 ± 11.51 years) affected by bipolar disorder (BD), in partial remission (DSM IV) and intolerant to lithium, were treated with GBP at a dose ranging from 300 to 2400 mg/day (mean ± SD: 1010.86 ± 268.55mg; 13.81 ± 4.21 mg/kg) for 1 year. Clinical assessments were performed with the Brief Psychiatric Rating Scale (BPRS), the Hamilton Rating Scale for Depression (HRS-D), the Hamilton Rating Scale for Anxiety (HRS-A) and the Manic Rating Scale (MRS) at baseline (T0), after 15 days (T0.5), after 30 days (T1), and then every month for 12 months. Mean HRS-D, HRS-A and MRS scores did not show any significant variation during the study. Only one patient showed a clinical relapse. The most frequent adverse events reported by patients were dizziness (1%), dry mouth (1%) and sedation (0.5%). There was a significant negative correlation between GBP dosage (mg/kg) and HRS-A score. Mean leucocyte and neutrophil counts showed a significant increase during the study. These preliminary data show potential efficacy and good tolerability of GBP in the prophylaxis of BD, but double-blind studies are required.
Published: 2001
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42. Predictive Value of Amino Acids in the Treatment of Major Depression with Fluvoxamine

Author: C. P C Steinhilber, L.S. Volonteri, V. Laini, Massimo C. Mauri, Marta E. Scalvini, Federica Zamberlan, and L. Boscati
Subjects: Adult, Blood Platelets, Male, medicine.medical_specialty, Fluvoxamine, Predictive Value of Tests, Internal medicine, Melancholia, medicine, Humans, Amino Acids, Psychiatry, Biological Psychiatry, Depression (differential diagnoses), Aged, chemistry.chemical_classification, Analysis of Variance, Depressive Disorder, Major, Mean age, Middle Aged, Predictive value, Amino acid, Psychiatry and Mental health, Neuropsychology and Physiological Psychology, chemistry, Predictive value of tests, Female, Analysis of variance, medicine.symptom, Psychology, Selective Serotonin Reuptake Inhibitors, medicine.drug
Abstract: Sixteen outpatients (mean age ± SD 50.18 ± 11.55 years; 11 females and 5 males) affected by major depression without melancholia (DSM-IV) were included in the study. The control group consisted of 11 healthy volunteers (mean age ± SD 39.90 ± 13.39 years; 2 females and 9 males). Patients were treated with fluvoxamine (FVX) 100–300 mg daily. Clinical assessment was performed using the Hamilton Rating Scales for Anxiety and Depression (HRS-A; HRS-D) and the Clinical Global Impression Scale (CGI) at basal time (T₀), after 4 weeks and after 8 weeks (T8). Plasma and platelet amino acid levels were determined at T₀ in all the subjects and also at T8 in depressed patients. A significant clinical improvement was observed in depressed patients according to the HRS-A (p = 0.004), HRS-D (p = 0.008) and CGI (p = 0.002). A negative correlation (r = –0.53, p = 0.049) was found between platelet levels of valine and HRS-D improvement rate. Patients showed significantly higher tyrosine/large neutral amino acids (LNAAs) and lower tryptophan/LNAAs, ratios which could represent an index of good response to a serotonergic drug like FVX.
Published: 2001
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43. Heart rate variability at high altitude in mountain marathon runners during sleep at 3480 m

Author: BANFI , GIUSEPPE, S. Defendi, I. Gritti, C. Mauri, G. Roi, Banfi, Giuseppe, S., Defendi, I., Gritti, C., Mauri, and G., Roi
Subjects: mountain marathon runner, heart rate variability, altitude
Published: 2008

44. Changes in blood chemistry, acid-base, electrolyte, blood lactate and dehydration metabolism and sleep at 3480 m in mountain marathon runners

Author: BANFI , GIUSEPPE, S. Defendi, I. Gritti, C. Mauri, P. Prato, G. Roi, Banfi, Giuseppe, S., Defendi, I., Gritti, C., Mauri, P., Prato, and G., Roi
Published: 2008

45. QUALITY OF LIFE AND TREATMENT SATISFACTION IN PATIENTS WITH TYPE 1 DIABETES: A COMPARISON BETWEEN CONTINUOUS SUBCUTANEOUS INSULIN INJECTION AND MULTIPLE DAILY INJECTIONS

Author: Nicolucci A, Maione A, Franciosi M, Amoretti R, Busetto R, Capani F, Bruttomesso D, Di Bartolo P, Girelli A, Leonetti F, Morviducci L, Ponzi P, VitacolonnaE on behalf of the EQuality Study Group:LV Cassano, N. Tota Ospedale Generale Regionale Miulli, Acquaviva delle Fonti, V. Cherubini, A. Iannilli Università Politecnica di Ancona, AO G. Salesi, Ancona, A. Corsi, P. Ponzani UOC Genova Ponente, SO La Colletta, Arenzano, V. Montani, P. Di Berardino PO di Atri, M. Velussi Casa di Cura Pineta del Carso, Aurisina, F. Giorgino, V. Gigantelli Università degli Studi di Bari, G. Beltramello, A. Pianta CAD Bassano Bassano del Grappa, R. Trevisan, G. Lepore Ospedali Riuniti di Bergamo, G. Forlani, G. Marchesini Università degli Studi di Bologna, D. Crazzolara, M. Marchesi Ospedale di Bolzano, E. Zarra, B. Agosti Spedali Civili di Brescia, G. Careddu Ospedale SS Prosperie Caterina, Camogli, L. Tomaselli, R. Vigneri Ospedale Garibaldi Nesima, Catania, M. Agrusta, V. Di Blasi PO di Cava dei Tirreni, S. Tumini, MT Anzellotti / E. Vitacolonna, F. Capani Università G. D’Annunzio, Chieti e. Pescara, P. Ruggeri Azienda Istituti Ospedalieri, Cremona, P. Foglini, M. Rossana Ospedale A. Murri, Fermo, S. Toni, MF Reali AO Universitaria degli Studi Meyer, Firenze, M. Nizzoli, S. Aquati Ospedale Morgagni, Forlì, G. d'Annunzio, N. Minuto Istituto G. Gaslini, Genova, L. Cataldi, C. Bordone AO Università San Martino, R. Iannarelli, F. Sciarretta PO San Salvatore, L'Aquila, M. Tagliaferri, MA Lezzi Ospedale G. Vietri, Larino, L. Sciangula, A. Ciucci Ospedale di Mariano Comense, M. Bonomo, E. Meneghini AO Ospedale Niguarda Ca' Granda, Milano, G. Mariani, P. Colapinto AO San Carlo Borromeo, G. Testori, P. Rampini AO Fatebenefratelli e. Oftalmico, R. Bonfanti, F. Meschi / G. Galimberti, A. Laurenzi Istituto Scientifico Ospedale San Raffaele, A. Veronelli, C. Mauri Ospedale San Paolo, C. Tortul, AM Cernigoi Ospedale San Paolo, Monfalcone, ME De Feo, M. Piscopo AORN A. Cardarelli, Napoli, G. Annuzzi, L. Bozzetto / A. Franzese, P. Buono / S. Turco, AA Turco AOU Università Federico II, F. Prisco, Seconda Università di Napoli, M. Trovati, P. Massucco AS Ospedale San Luigi Gonzaga, Orbassano, S. Costa, M. Dal Pos Università degli Studi di Padova, V. Provenzano, L. Strazzera Ospedale Civico di Partitico, Palermo, G. Ridola Poliambulatorio Oreto Guadagna, E. Torlone, M. Orsini Federici Università degli Studi di Perugia, A. Bertolotto, M. Aragona AO Universitaria Pisana, Pisa, P. Di Bartolo, F. Pellicano AUSL Provincia di Ravenna, V. Manicardi, M. Michelini Ospedale di Montecchio, Reggio Emilia, M. Parenti, AC Babini Ospedale degli Infermi, Rimini, P. Borboni, A. Di Flaviani / ML Manca Bitti, S. Piccinini AO Universitaria Policlinico Tor Vergata, Roma, A. Clementi, C. Tubili – AO San Camillo Forlanini, C. Suraci, S. Carletti Ospedale Sandro Pertini, ASL RMB, A. Moretti, M. Maiello F. Leonetti, VC Iannucci N. Sulli, B. Shashaj Università La Sapienza, Policlinico Umberto I, D. Fava, F. Massimiani AO S. Giovanni Addolorata, P. Pozzilli, S. Manfrini Università Campus Bio Medico, S. Manfrini, C. Landi ASUR Marche, Zona Territoriale n. 4, Senigallia, I. Tanganelli Università degli Studi di Siena, G. Grassi, M. Tomelini ASO San Giovanni Battista di Torino, R. De Luca, L. Corgiat Mansin Ospedale Oftalmico ASL 1, Torino, R. Candido, E. Manca ASS 1 Triestina, Trieste, L. Tonutti, C. Noacco AO Universitaria, Udine, I. Franzetti, P. Marnini AO Universitaria, Varese, IAFUSCO, Dario, Nicolucci, A, Maione, A, Franciosi, M, Amoretti, R, Busetto, R, Capani, F, Bruttomesso, D, Di Bartolo, P, Girelli, A, Leonetti, F, Morviducci, L, Ponzi, P, VitacolonnaE on behalf of the EQuality Study Group:LV, Cassano, N., Tota Ospedale Generale Regionale Miulli, Acquaviva delle, Fonti, V., Cherubini, A., Iannilli Università Politecnica di Ancona, AO G., Salesi, Ancona, A., Corsi, P., Ponzani UOC Genova Ponente, SO La, Colletta, Arenzano, V., Montani, P., Di Berardino PO di Atri, M., Velussi Casa di Cura Pineta del Carso, Aurisina, F., Giorgino, V., Gigantelli Università degli Studi di Bari, G., Beltramello, A., Pianta CAD Bassano Bassano del Grappa, R., Trevisan, G., Lepore Ospedali Riuniti di Bergamo, G., Forlani, G., Marchesini Università degli Studi di Bologna, D., Crazzolara, M., Marchesi Ospedale di Bolzano, E., Zarra, B., Agosti Spedali Civili di Brescia, G., Careddu Ospedale SS Prosperie Caterina, Camogli, L., Tomaselli, R., Vigneri Ospedale Garibaldi Nesima, Catania, M., Agrusta, V., Di Blasi PO di Cava dei Tirreni, S., Tumini, MT Anzellotti / E., Vitacolonna, F. Capani Università G., D’Annunzio, Chieti e., Pescara, P., Ruggeri Azienda Istituti Ospedalieri, Cremona, P., Foglini, M. Rossana Ospedale A., Murri, Fermo, S., Toni, MF Reali AO Universitaria degli Studi, Meyer, Firenze, M., Nizzoli, S., Aquati Ospedale Morgagni, Forlì, G., D'Annunzio, N. Minuto Istituto G., Gaslini, Genova, L., Cataldi, C., Bordone AO Università San Martino, R., Iannarelli, F., Sciarretta PO San Salvatore, L'Aquila, M., Tagliaferri, MA Lezzi Ospedale G., Vietri, Larino, L., Sciangula, A., Ciucci Ospedale di Mariano Comense, M., Bonomo, E., Meneghini AO Ospedale Niguarda Ca' Granda, Milano, G., Mariani, P., Colapinto AO San Carlo Borromeo, G., Testori, P. Rampini AO Fatebenefratelli e., Oftalmico, R., Bonfanti, F. Meschi / G., Galimberti, A., Laurenzi Istituto Scientifico Ospedale San Raffaele, A., Veronelli, C., Mauri Ospedale San Paolo, C., Tortul, AM Cernigoi Ospedale San, Paolo, Monfalcone, ME De, Feo, M. Piscopo AORN A., Cardarelli, Napoli, G., Annuzzi, L. Bozzetto / A., Franzese, P. Buono / S., Turco, AA Turco AOU Università Federico, Ii, F., Prisco, Iafusco, Dario, Seconda Università di, Napoli, M., Trovati, P., Massucco AS Ospedale San Luigi Gonzaga, Orbassano, S., Costa, M., Dal Pos Università degli Studi di Padova, V., Provenzano, L., Strazzera Ospedale Civico di Partitico, Palermo, G., Ridola Poliambulatorio Oreto Guadagna, E., Torlone, M., Orsini Federici Università degli Studi di Perugia, A., Bertolotto, M., Aragona AO Universitaria Pisana, Pisa, P., Di Bartolo, F., Pellicano AUSL Provincia di Ravenna, V., Manicardi, M., Michelini Ospedale di Montecchio, Reggio, Emilia, M., Parenti, AC Babini Ospedale degli, Infermi, Rimini, P., Borboni, A., Di Flaviani / ML Manca Bitti, S., Piccinini AO Universitaria Policlinico Tor Vergata, Roma, A., Clementi, C., Tubili – AO San Camillo Forlanini, C., Suraci, S., Carletti Ospedale Sandro Pertini, Asl, Rmb, A., Moretti, M. Maiello F., Leonetti, VC Iannucci N., Sulli, B., Shashaj Università La Sapienza, Policlinico Umberto, I, D., Fava, F. Massimiani AO S., Giovanni Addolorata, P., Pozzilli, S., Manfrini Università Campus Bio Medico, S., Manfrini, C., Landi ASUR Marche, Zona Territoriale n., 4, Senigallia, I., Tanganelli Università degli Studi di Siena, G., Grassi, M., Tomelini ASO San Giovanni Battista di Torino, R., De Luca, L., Corgiat Mansin Ospedale Oftalmico ASL 1, Torino, R., Candido, E., Manca ASS 1 Triestina, Trieste, L., Tonutti, C., Noacco AO Universitaria, Udine, I., Franzetti, P., Marnini AO Universitaria, and Varese
Published: 2007

46. Long term efficacy of paroxetine in major depression: A study with plasma levels

Author: Lorenzo Mapelli, Antonella Bitetto, Renata Rudelli, Massimo C. Mauri, L. Boscati, Marta E. Scalvini, and V. Laini
Subjects: medicine.medical_specialty, Plasma levels, medicine.disease, Paroxetine, Psychiatry and Mental health, Tolerability, Rating scale, medicine, Major depressive disorder, Clinical efficacy, Psychology, Psychiatry, Depression (differential diagnoses), medicine.drug
Abstract: Depressive disorders can be regarded as recurrent and chronic conditions that may reduce the quality of life and work output of patients. Data on the long-term efficacy of paroxetine appear to indicate that it is an effective maintenance treatment. Our aim was to measure paroxetine concentrations in plasma in order to optimize its clinical efficacy and tolerability during long-term treatment. We studied 35 patients aged 23-70 years, suffering from Major Depressive Disorder (recurrent). These patients received 10-50 mg of paroxetine once a day for one year; they were evaluated at baseline, after 2 weeks and then after 1,2,6,9 and 12 months by BPRS, HRS-D and HRS-A rating scales, and at the same time, any side-effects were assessed and samples for paroxetine plasma determination were also collected. Results confirmed the efficacy and tolerability of paroxetine for long-term treatment. We observed a curvilinear relationship between plasma paroxetine levels and improvement on the HRS-D with greater clinical amelioration at plasma levels between 20 and 70 ng/ml.
Published: 1999
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47. Clozapine metabolism rate as a possible index of drug-induced granulocytopenia

Author: Renata Rudelli, E. Giuliani, R. Orlandi, A. Guerrini, S. Gianetti, Giordano Invernizzi, Massimo C. Mauri, and Bravin S
Subjects: Adult, Male, Drug, medicine.medical_specialty, Leukocytosis, media_common.quotation_subject, Leukocyte Count, Pharmacokinetics, Risk Factors, Internal medicine, Humans, Medicine, Clozapine, media_common, Pharmacology, Leukopenia, business.industry, Plasma levels, Metabolism, Middle Aged, Endocrinology, Toxicity, Schizophrenia, Absolute neutrophil count, Female, medicine.symptom, business, Agranulocytosis, Antipsychotic Agents, medicine.drug
Abstract: A possible relationship between haematological adverse reactions and clozapine (CLZ) metabolism rate was studied. Sixteen chronic schizophrenic outpatients (mean age 34.62 years +/- 7.56 SD) were treated with CLZ, 75-600 mg/daily for 9 weeks. CLZ and norclozapine (NCLZ) plasma levels were determined weekly, contemporarily with blood cell counts. CLZ plasma levels ranged from 25 to 1270 ng/ml (mean 266.27 ng/ml +/- 197.44 SD), while NCLZ plasma levels ranged from 25 to 1280 ng/ml (mean 169.0 ng/ml +/- 127.94 SD). NCLZ/CLZ ratio ranged from 0.13 to 1.72 (mean 0.72 +/- 0.28 SD). Leukocyte count ranged from 5.2 to 18.8 10(9)/l (mean 9.37 10(9)/l +/- 2.94 SD) and neutrophil count ranged from 1.8 to 13.4 10(9)/l (mean 5.73 +/- 2.57 SD). No correlation was found between CLZ dosage and NCLZ plasma levels. Both CLZ and NCLZ plasma levels correlated positively with neutrophil count (CLZ: P = 0.001, r = 0.26; NCLZ: P = 0.01, r = 0.20). The correlation between NCLZ/CLZ plasma level ratio and neutrophil count was significantly negative (P = 0.002, r = 0.25). These preliminary data suggest that the NCLZ/CLZ ratio, as an index of CLZ metabolism, might be a possible risk factor associated with CLZ treatment.
Published: 1998
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48. Psychopathological and cognitive features in subclinical hypothyroidism

Author: Antonio Vita, Vincenzina Amodei, Bravin S, Massimo C. Mauri, Luigi Cantalamessa, I.Marina Baldini, and Massimiliano Carrisi
Subjects: Adult, endocrine system, medicine.medical_specialty, Pediatrics, Psychometrics, endocrine system diseases, Population, Levothyroxine, Thyrotropin, Anxiety, Hypothyroidism, Memory, Rating scale, Brief Psychiatric Rating Scale, Reaction Time, medicine, Humans, Psychiatry, education, Biological Psychiatry, Aged, Psychiatric Status Rating Scales, Pharmacology, education.field_of_study, Depression, Goiter, Mood Disorders, Cognitive disorder, Wechsler Adult Intelligence Scale, Rating scales for depression, Middle Aged, medicine.disease, Thyroxine, Triiodothyronine, Female, Thyroid function, Cognition Disorders, Psychology, medicine.drug
Abstract: 1. To evaluate effective and cognitive dysfunctions in subjects with a marginal form of thyroid hypofunction the authors studied a population of female goiter patients, divided in two groups on the basis of thyroid function: euthyroidism and subclinical hypothyroidism (SCH). 2. The SCH patients were treated with levothyroxine (LT4) in order to obtain euthyroidism, as demonstrated by normalization of the hormonal pattern. 3. Both groups were evaluated with a wide range of psychometric tests (Wechsler memory test, scribble test, reaction times) and psychopathological rating scales (Hamilton rating scales for depression and anxiety, brief psychiatric rating scale) at admission and after 3 months. 4. At admission, a significant decrease in logical memory was found in SCH patients; no differences in affectivity ratings were found between the groups. 5. After LT4 treatment, SCH patients showed a significant improvement in some items of memory performance. 6. In conclusion, when interfering factors relating to the perception of disease were excluded by employing euthyroid goiter patients as a comparison group, SCH appeared associated only with memory impairment, while the impairment of affective functions described in previous studies comparing SCH patients with normal controls was not confirmed. A significant improvement of memory skills was induced by LT4 treatment in SCH patients.
Published: 1997
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49. A Risk-Benefit Assessment of Sulpiride in the Treatment of Schizophrenia

Author: Bravin S, Giordano Invernizzi, Antonella Bitetto, Renata Rudelli, and Massimo C. Mauri
Subjects: Male, Risk, medicine.medical_specialty, medicine.drug_class, Atypical antipsychotic, Pharmacology, Toxicology, chemistry.chemical_compound, Dopamine, Internal medicine, medicine, Humans, Pharmacology (medical), Risk factor, Receptor, Benzamide, business.industry, medicine.disease, Endocrinology, Mechanism of action, chemistry, Schizophrenia, Female, Sulpiride, medicine.symptom, business, Antipsychotic Agents, medicine.drug
Abstract: Sulpiride is a substituted benzamide with a selective action on receptors of the dopamine D2-like family, and clinical and pharmacological data suggest that it could be considered to be an atypical antipsychotic. Sulpiride penetrates the blood-brain barrier poorly because of its low lipid solubility. It is mainly excreted unchanged in the urine, and accumulation of the drug could occur in patients with renal dysfunction and possibly in elderly patients with declining glomerular filtration rate. At low dosages (50 to 150 mg/day), sulpiride produces a disinhibiting and antidepressant effect, which is probably related to its action on D2 presynaptic autoreceptors, thus facilitating dopaminergic neurotransmission. Data have confirmed the efficacy of sulpiride in patients with acute or chronic schizophrenia during both short and long term treatment, but long term, placebo-controlled trials are still lacking. It is still doubtful whether sulpiride is more effective than typical antipsychotics for the treatment of negative symptoms. Data from clinical studies are controversial; the majority of authors indicate that sulpiride produces a better recovery rate from negative than from positive symptoms at low doses, but it shows a similar efficacy either on negative and positive symptoms at higher doses. The safety profile of sulpiride is similar to that of typical antipsychotics, although the frequency of adverse effects seems to be globally lower. Extrapyramidal reactions appear generally to be mild. Autonomic effects occur less frequently with sulpiride than with typical antipsychotics, showing no clinically relevant influence on cardiovascular parameters and, on the whole, good tolerability in elderly patients. Sulpiride is known to induce prolactin elevation in both serum and CSF, which may be associated with impotence in men and diminished gonadal function in women; these effects appear to be dosage-dependent. Sulpiride can be considered to be an atypical antipsychotic, considering its action on negative, defective symptoms, its partial activity against positive symptoms, and its low incidence of extrapyramidal adverse effects. Sulpiride could find its specific therapeutic role in elderly patients with schizophrenia, as it shows a good margin of safety between therapeutic dosages and toxic concentrations.
Published: 1996
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50. Understanding the pharmacokinetics of anxiolytic drugs

Author: Silvio R. Bareggi, Alfredo Carlo Altamura, D. Moliterno, Silvia Paletta, Michele Maffini, and Massimo C. Mauri
Subjects: medicine.medical_specialty, Cyclohexanecarboxylic Acids, medicine.drug_class, Adrenergic beta-Antagonists, Pregabalin, Histamine Antagonists, Toxicology, Anxiolytic, Buspirone, Benzodiazepines, Sleep Initiation and Maintenance Disorders, medicine, Humans, Amines, Psychiatry, gamma-Aminobutyric Acid, Pharmacology, Bromazepam, business.industry, Lorazepam, General Medicine, Anxiety Disorders, Propranolol, Clonazepam, Alprazolam, Anti-Anxiety Agents, Atenolol, Hydroxyzine, Anticonvulsants, Etizolam, Gabapentin, business, medicine.drug
Abstract: Anxiety disorders are considered the most common mental disorders and they can increase the risk for comorbid mood and substance use disorders, significantly contributing to the global burden of disease. For this reason, anxiolytics are the most prescribed psychoactive drugs, particularly in the Western world.This review aims to analyze pharmacokinetic profile, plasma level variations so as the metabolism, interactions and possible relation to clinical effect of several drugs which are used primarily as anxiolytics. The drugs analyzed include benzodiazepines, anticonvulsants (pregabalin, gabapentin), buspirone, β-blockers and antihistamines (hydroxyzine). Regarding the most frequently used anxiolytic benzodiazepines, data on alprazolam, bromazepam, chlordesmethyldiazepam, chlordiazepoxide, clotiazepam, diazepam, etizolam, lorazepam, oxazepam, prazepam and clonazepam have been detailed.There is a need for a more balanced assessment of the benefits and risks associated with benzodiazepine use, particularly considering pharmacokinetic profile of the drugs to ensure that patients, who would truly benefit from these agents, are not denied appropriate treatment. An optimal pharmacological approach involving an integrative pharmacokinetic and pharmacodynamic optimization strategy would ensure better treatment and personalization of anxiety disorders. So it would be desirable for the development of new anxiolytic drug(s) that are more selective, fast acting and free from the unwanted effects associated with the traditional benzodiazepines as tolerance or dependence.
Published: 2013

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