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Clinical outcome and tolerability of sertraline in major depression
- Source :
- Progress in Neuro-Psychopharmacology and Biological Psychiatry. 26:597-601
- Publication Year :
- 2002
- Publisher :
- Elsevier BV, 2002.
-
Abstract
- Sertraline (SRT) has been shown to be an effective antidepressant in extensive clinical trial programs but data on plasma concentrations regarding clinical outcome and tolerability are lacking. Twenty-one out-patients of both sexes, with mean age of 50.23 years (S.D. = 17.37), affected by major depressive disorder, recurrent (Diagnostic and Statistical Manual of Mental Disorder--IV, DSM-IV), were treated with 25-150 mg of SRT once a day (mean=66.26 mg, S.D.=30.50) for 30 days. Clinical evaluation was assessed at baseline (T0), after 15 days (T15), and then after 30 days (T30). Plasma samples for SRT level determination were collected at T30. Brief Psychiatric Rating Scale (BPRS), Hamilton Rating Scale for Depression (HRS-D), and Hamilton Rating Scale for Anxiety (HRS-A) showed a significant improvement during the study (P
- Subjects :
- Pharmacology
Sertraline
medicine.medical_specialty
book.periodical
Nausea
Hamilton Rating Scale for Depression
medicine.disease
Tolerability
Cephalalgia
Rating scale
Internal medicine
Anesthesia
Brief Psychiatric Rating Scale
medicine
Major depressive disorder
medicine.symptom
Psychology
book
Biological Psychiatry
medicine.drug
Subjects
Details
- ISSN :
- 02785846
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Accession number :
- edsair.doi...........860d7cefb9dfd5de86a5cc6f3cb65dcd