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Summary After oral administration of CCI4 and CBrCI3, products of reaction of trichloromethyl free radical (CCI3) were identified by electron-capture gas chromatography. In rat livers 15 minutes after treatment with CCI4, the metabolites CHCI3 and C2CI6 were detected. CHCI3, CCI4, CHBrCI2 and C2CI6 were present 15 min after administration of CBrCI3: the possible formation of the radical CBrCI2 in addition to CCI3 by liver metabolism should also be taken into consideration.

This research was carried on denervated isolated rat stomach. Mechanical response to Ach treated with three different ATN II concentrations was recorded. No competitive antagonism was observed so that no common receptor can be supposed. The apparent noncompetitive antagonism may be ascribed to the action of ATN II on P and T Ca++ activating systems.

The concentrations of gamma-amino-n-butyric acid in brains of rats intoxicated with half intraperitoneal LD50 ethanol were determined at various times and found increased at early times (10 min) and decreased later (1 to 3 hours). The concentration tended to be restored to normal values upon administration of n-dipropylacetate (400 mg/kg) or L-glutamine (340 mg/kg). The treatment with both substances showed a positive interaction with an overall positive effect greater than the sum of each.

It was tested on guinea-pig "Taenia-Coli" the interaction between ATN II and Ach in order to elucidate if there is an antagonism or an independence in the action of the two substances. It was concluded that there is no antagonism but a certain degree of interference.

Male and female rats were treated with estradiol benzoate in the 5 degrees day of life. The avoidance conditioning, tested after 65 days, was significatively impaired in males treated with estradiol, a significative retardation was observed in females treated, but no significant end-difference versus no-treated females. It is supposed that a hormone induced synaptic shaft/spines ratio in preoptic area may be involved in avoidance conditioning.

1-C-(1-Acetylacetonyl)-2-deoxy-2-(1-methyl-3-oxobut-1-enyl)amino -d-galactitol is obtained from the condensation of 2-amino-2-deoxy-d-galactose with pentane-2,4-dione in anhydrous solvent. On treatment with hot alkali it gives 2-methylpyrrole with 37% yield. By acid hydrolysis under mild conditions the compound loses the N substituent and from the resulting unstable derivative 2-methylpyrrole is obtained (52% yield). It is concluded that derivatives of aminohexoses substituted at C-1 with a dioxopentyl chain are the precursors of 2-methylpyrrole in the Cessi & Serafini-Cessi (1963) modification of the Elson–Morgan reaction. As demonstrated previously, products of condensation of aminohexoses with pentane-2,4-dione at the amino group are not converted directly into 2-methylpyrrole, but this step provides protection of the amino group during condensation at C-1.