Detection of early metabolites in rat liver after administration of CCI4 and CBrCI3

Summary After oral administration of CCI4 and CBrCI3, products of reaction of trichloromethyl free radical (CCI3) were identified by electron-capture gas chromatography. In rat livers 15 minutes after treatment with CCI4, the metabolites CHCI3 and C2CI6 were detected. CHCI3, CCI4, CHBrCI2 and C2CI6 were present 15 min after administration of CBrCI3: the possible formation of the radical CBrCI2 in addition to CCI3 by liver metabolism should also be taken into consideration.