15 results on '"C. Ahouada"'
Search Results
2. P137 Viral hepatitis prevalence among men who have sex with men recruited in an HIV PrEP demonstration study in Cotonou, Benin
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Frédéric Kintin, C Ahouada, Marcel Zannou, Fernand Guédou, A Akpaka, Marlène Aza-Gnandji, Luc Béhanzin, S Ogoundele, Michel Alary, M Goma, Flore Gangbo, A Dossouvo, E Chagas, and M Olodo
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Hepatitis ,HBsAg ,medicine.medical_specialty ,education.field_of_study ,business.industry ,Population ,Psychological intervention ,virus diseases ,Hepatitis A ,Hepatitis B ,medicine.disease ,digestive system diseases ,Men who have sex with men ,Internal medicine ,medicine ,business ,education ,Viral hepatitis - Abstract
Background Men who have sex with men (MSM) are disproportionally affected by hepatitis worldwide despite the availability of safe and effective vaccines for hepatitis A and B. The aim of this analysis was to estimate the prevalence and risk factors for current and lifetime hepatitis B, and HCV antibodies among MSM in Cotonou. Methods A two-stage cluster sampling procedure was used to recruit 204 MSM in the community-based PrEP demonstration study. First, 7 out of the 13 boroughs in Cotonou were selected using a probability proportional to size method and a fixed number of MSM were then randomly selected from each borough using a random route sampling procedure. A rapid immuno-chromatographic test was used for detecting HBV surface antigen (HBsAg, active infection) and HCV antibodies in whole blood. Enzyme immunoassays were used for detecting HBV core (anti-HBc) and surface (anti-HBs) antibodies (lifetime infection: HBsAg or anti-HBc positivity without anti-HBs). Risk factors analyses controlled for potential confounders using log-binomial regression. Results The prevalence of active and lifetime HBV were 8.8% and 37.7%, respectively. Only two men were HCV-positive (0.98%). Both current (16.7% versus 6.4%, p Conclusion HBV is frequent in this population, especially in older MSM who are more likely to have started their sexual life before the initiation of MSM-specific interventions in Benin (2008). HCV prevalence was low, likely because of the absence of injectable drug use and the fact that all participants were HIV-negative. HBV vaccination, offered free of charge to children in Benin since 2005, should also be systematically offered to MSM susceptible to this infection.
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- 2021
3. Prévalence de l’antigénémie cryptococcique et les facteurs associés chez les patients infectés par le VIH à Cotonou au Bénin
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G. Ayihounton, Aurore Ogouyemi-Hounto, Angèle Azon-Kouanou, C. Ahouada, J. Acakpo, Y. Sissinto Savi de Tove, D. Kinde Gazard, and D.M. Zannou
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Gynecology ,03 medical and health sciences ,medicine.medical_specialty ,0302 clinical medicine ,Infectious Diseases ,business.industry ,030231 tropical medicine ,Human immunodeficiency virus (HIV) ,Medicine ,030212 general & internal medicine ,business ,medicine.disease_cause - Abstract
Resume Objectif Determiner la prevalence de l’antigenemie cryptococique chez les patients infectes par le VIH a Cotonou en vue de la mise en place d’un depistage systematique. Patients et methodes Il s’agit d’une etude transversale, descriptive et analytique menee de juin a septembre 2015 dans quatre centres de traitement ambulatoire aupres des patients adultes vivant avec le VIH, beneficiant ou non d’un traitement antiretroviral avec un nombre de CD4 ≤ 200 cell/μL. Pour chaque patient enrole, apres la signature du formulaire de consentement, il a ete realise un examen clinique, puis l’administration d’un questionnaire permettant de collecter les renseignements generaux, biologiques et therapeutiques. Ensuite un prelevement sanguin pour le comptage des lymphocytes CD4 et la recherche de l’antigenemie cryptococique ont ete faits. Resultats Au total, 355 patients sont inclus dans l’etude avec une moyenne d’âge de 40 ± 10,2 ans. La prevalence globale de l’antigenemie cryptococcique est de 1,7 %. Tous les patients ayant une antigenemie positive ont un taux de CD4 inferieur a 100 cell/μL avec une majorite ayant un taux 2 , un etat general altere avec un taux de lymphocyte CD4 Conclusion Cette etude pilote a montre une faible prevalence de l’antigenemie cryptococcique dans la population d’etude, mais plus elevee chez les patients tres immunodeprimes avec un taux de CD4
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- 2016
4. [Prevalence and factors associated with cryptococcal antigenemia in HIV-infected patients in Cotonou/Benin]
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A, Ogouyèmi-Hounto, D M, Zannou, G, Ayihounton, C, Ahouada, A, Azon-Kouanou, J, Acakpo, Y, Sissinto Savi de Tove, and D, Kinde Gazard
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Adult ,Male ,Antigens, Fungal ,AIDS-Related Opportunistic Infections ,HIV Infections ,Pilot Projects ,Cryptococcosis ,Meningitis, Cryptococcal ,Middle Aged ,CD4 Lymphocyte Count ,Cryptococcus ,Cross-Sectional Studies ,Risk Factors ,HIV-1 ,Prevalence ,Benin ,Humans ,Female - Abstract
Determine the prevalence of cryptococcal antigenemia and associated factors in HIV-infected patients in Cotonou in order to introduce systematic screening in national guidelines.This is a cross-sectional, descriptive and analytical study conducted from June to September 2015 in four outpatient treatment centers with adult patients infected with HIV, receiving or not antiretroviral treatment with a number of CD4≤200cell/μL and who have given their informed consent to participate in the study. For each enrolled patient, after signing the informed consent form, it was made a clinical examination and administration of a questionnaire to collect general information, treatment and biological data. Then a blood sample for counting CD4 lymphocytes and the search of cryptococcal antigenemia were done.In total, 355 patients were included in the study with a mean age of 40±10.2years. The overall prevalence of cryptococcal antigenemia is 1.7%. All patient with cryptococcal antigenemia have a CD4 count below 100cells/μL with a majority having CD4 count below 50cells/μL. Body mass index18.5kg/mThis pilot study showed a low prevalence of cryptococcal antigenemia in the study population, but higher in highly immuno-deficient patients with CD4 counts50cells/μl. Given the results obtained, the introduction of routine screening among patients infected with HIV could be reserved to those with CD4 counts50cells/μl.
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- 2016
5. Detection and management of drug-resistant tuberculosis in HIV-infected patients in lower-income countries
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I. Izabelle, F. Ello, H. Ssemuwemba, S. Phiri, J. Olasode, Marie-Sylvie N’Gbeche, S. Kouadio, Jesper Eugen-Olsen, M. Mpoudi-Etame, Cristin Q. Fritz, S. Dapiap, J. Zoungrana, Antoine Jaquet, Aristophane Tanon, Rasmata Ouédraogo, N. T. Loan, E. J. Carter, Obaseki, F. F. Diakité, H. X. Zhao, Kulkanya Chokephaibulkit, Z. J. da Silva, Peter Aaby, Dewi Kumara Wati, David da Silva, L. Ayangma, K. Jjingo, P. Kim, Romanee Chaiwarith, James Ndirangu, Valériane Leroy, L. P. P. Atmikasari, N. Zobo, H. Chenal, Rita Lyamuya, Catherine C. McGowan, Keswadee Lapphra, Wanatpreeya Phongsamart, B. B. Mwebesa, Théodore Niyongabo, D. Katile, B. Ba, Matthias Egger, L. Mofenson, A. Mounkaila-Harouna, Boris Tchounga, M. Moh, Elom Takassi, Haby Signaté Sy, G. Sagbo, F. Kaeser, Eduardo Gotuzzo, Guillaume Bado, C. C. McGowan, S. Karcher, Constantin T. Yiannoutsos, V. H. Bui, Christopher J. Hoffmann, Didier K. Ekouevi, J. Akakpo, I. Azinyue, S. Kiertiburanakul, S. O. Koule, W. Bishai, Mariam Guindo Traoré, C. Williams, Elise Arrivé, A. Tapsoba, S. Bessekon, Patrick A. Coffie, F. Yuliana, A. Gougounon-Houéto, Somnuek Sungkanuparph, Y. Abo, Q. Vo, Praphan Phanuphak, M. B. Kokora, Kouadio Kouakou, Fla Kouéta, M. E. Dainguy, O. Benson, I. Soré, W. Prasitsuebsai, Harry Moultrie, C. Guehi, Beatriz Grinsztejn, T. Q. Du, L. Diecket Ahoussou, Z. Diallo, N. Traoré, Firas Wehbe, C. V. Do, J. Tatwangire, A. Kotosso, F. Soppi, Amabelia Rodrigues, Juan Sierra Madero, P. S. Sow, Rodolphe Thiébaut, I. Y. Malino, Moussa Seydi, Helena Rabie, A. Dienderé, Geoffrey Somi, Emmanuel Bissagnene, Elizabeth A. Bukusi, H. C. Traoré, David A. Cooper, N. M. Manga, P. Osakede, S. Ajayi, J. Paulo, Marguerite Timite-Konan, Andrew Edmonds, B. Diop, A. M. Traoré, W. Hiembo, A. Koïta, M. Faye, A. Azon-Kouanou, Christian Wejse, Claudia P. Cortes, T. Pety, N. Durier, Thira Sirisanthana, Camille Ndondoki, Karl-Günter Technau, J. S. Elvis Diby, G. Alim, M. D'Almeida, A. Komi, J. Bashi, J. M. Tine, D. Hawerlander, R. Ditangco, Akouda Patassi, A. Kalle, F. J. Zhang, Lorna Renner, N. H. Chau, Janet Giddy, G. Clouet, Samwel O. Ayaya, A. Sohn, Lars Østergaard, Sylvie Ouédraogo, Clement Adebamowo, Azar Kariminia, John Ssali, Joseph Drabo, M. Dembelé, Nicola Maxwell, Albert Minga, M. D.N. Amego, Wilai Kotarathititum, Christian Erikstrup, H. A. Traore, Kapella Zacharia Ngonyani, E. Geng, Lukas Fenner, A. Diagne, Marcelo Wolff, A. I. Assi, A. Sackey, A. R. Yao, M. F. Sami, Edmond Addi Aka, H. Adjide, Pagakrong Lumbiganon, Karen Malateste, L. Diero, M. Gansonré, P. N. An, A. H. Sohn, D. Meless, D. Avit-Edi, D. Walker, L. Hardwicke, A. S. Kaya, Véronique Mea-Assande, G. S. Gottlieb, Denis Padgett, Eric Balestre, Candida Medina, D. Amani, C. Kouakou, C. Shiboski, E Messou, B. G. Kariyare, M. Ballif, W. Wester, J. M. Gonsan, G. Gbadamassi, A. Ba, M. Fomba, Denis Malvy, R. Bantique, S. N. Owiafe, Andrew Kambugu, Festus Igbinoba, M. Y. Maiga, C. Ahomadegbé, A. Berthé, R. D. Gueye, C. C. Bassabi, Djimon Marcel Zannou, Olivia Keiser, Kara Wools-Kaloustian, K. E. Mensah-Zukong, A. Doring, C. Chimbetete, J. Rivenc, V. Andavi, F. Alihonou, S. Datté, S. Pestilli, T. Mengthaisong, Kathryn Anastos, A. D. Mbaye, D. Lameck, Claire Graber, J. Lewis-Kulzer, G. Reubenson, B. Siloué, Marcel Yotebieng, K. T.K. Dung, C. Ahouada, Severin Lenaud, J. Welbeck, D. Dickinsonn, L. Zoungrana, A. Avihingsanon, T. T. Cao, V. K. Nguyen, Morten Sodemann, J. C. Dusingize, B. Okwara, C. Lewden, H. Traoré, Patrick MacPhail, David C Boettiger, G. Oka-Berete, H. K. Truong, F. Houngbé, Robin Wood, Venerandah Nhandu, J. C. Azani, G. Wandeler, K. L. Issouf, K. C. Anzan, Andrea L. Ciaranello, Awachana Jiamsakul, M. T. Ha, K. Brou, M. Maskew, L. Tossa-Bagnan, B. Zerbo, P. Pakpame, Xavier Anglaret, Jean W. Pape, J. B. Essanin, A. Petit, A. Kouakou, E. Rabourdin, Orasri Wittawatmongkol, Daniela Garone, S. El-Hadj Djibril, S. Duda, C. Twizere, K. C. Chan, Annie J. Sasco, N. Sanmeema, N. V. Lam, J. Conrad, Q. T. Du, P. Tharnprisan, Z. Yao, A. Djeha, Siriatou A. Koumakpai, Joachim Gnokoro, I. Hodonou, Sabine Hermans, Timothy R. Sterling, C. Nchot, D. Minta, E. Yunihastuti, T. F. Eboua, T. Cissé, Revathy Nallusamy, Jeffrey S. A. Stringer, Dabis F, F. Bohossou, Brian Eley, E. Traore, R. McKaig, Matthew Law, Manhattan Charurat, G. M. Kouakou, Madeleine Amorissani Folquet, A. Mandalakas, Sophie Desmonde, S. Eholié, J. K. Assouan, Andrew Boulle, Tuti Parwati Merati, A. Koko Lawson-Evi, Eugene Mutimura, C. A. Bosse, M Dosso, Fred Nalugoda, T. T. Pham, T. Udomphanit, H. L. Ha, N. Kancheya, N. Han, J. Sehonou, S. N. Kangah, R. Huebner, A. Gasser, C. Gilbert, Appolinaire Horo, J. C. Kouakou, D. Yé, P. Acquah, A. Héma, Pope Kosalaraksa, Hans Prozesky, J. James, Fatoumata Dicko, P. Cahn, Moussa Doumbia, I. Oliviera-Souto, Morna Cornell, Elenore Judy B. Uy, G. Hounhoui, J. E. Carter, V. A. Yao, Adrien Sawadogo, B. Petersen, S. E. Reid, B. Goka, G. Carriquiry, M. A. Davies, P. Nipathakosol, J. Le Carrou, M. L. Lindegren, H. Dior, P. Cegielski, E. Baramperanye, Mariam Sylla, Anders Fomsgaard, P. Braitstein, S. T. Coulibaly, D. D. Cuong, C. N'Diaye, M. Kone, Dewa Nyoman Wirawan, A. Gitembagara, Niaboula Koné, K. Ruxrungtham, R. Bognounou, Aissatou Touré, A. Ephoévi-gah, Alex Lund Laursen, and Y. Atakouma
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Male ,Questionnaires ,West African ,Pediatrics ,Asia Pacific ,Antitubercular Agents ,HIV Infections ,Drug resistance ,rifampicin ,South Africa ,drug resistant tuberculosis ,Surveys and Questionnaires ,Tuberculosis, Multidrug-Resistant ,Central Africa ,antiretrovirus agent ,Human immunodeficiency virus infected patient ,clinical practice ,microbial sensitivity test ,Infectious Diseases ,priority journal ,urban population ,Female ,anti human immunodeficiency virus agent ,supply and distribution ,medicine.drug ,Pulmonary and Respiratory Medicine ,Adult ,isoniazid ,medicine.medical_specialty ,Tuberculosis ,Asia ,phenotype ,Anti-HIV Agents ,Developing country ,MDR-TB ,Microbial Sensitivity Tests ,purl.org/pe-repo/ocde/ford#3.03.08 [https] ,preventive medicine ,Article ,South and Central America ,socioeconomics ,medicine ,Humans ,controlled study ,human ,rural population ,drug sensitivity ,Developing Countries ,Directly Observed Therapy ,Preventive healthcare ,ART programs ,Caribbean ,business.industry ,questionnaire ,Drug resistant tuberculosis ,developing country ,CD4 lymphocyte count ,Central africa ,Central America ,South America ,medicine.disease ,major clinical study ,Latin America ,purl.org/pe-repo/ocde/ford#3.02.07 [https] ,Africa ,world health organization ,tuberculostatic agent ,business ,Rifampicin - Abstract
SETTING: Drug resistance threatens tuberculosis (TB) control, particularly among human immunodeficiency virus (HIV) infected persons.OBJECTIVE: To describe practices in the prevention and management of drug-resistant TB under antiretroviral therapy (ART) programs in lower-income countries.DESIGN: We used online questionnaires to collect program-level data on 47 ART programs in Southern Africa (n = 14), East Africa (n = 8), West Africa (n = 7), Central Africa (n = 5), Latin America (n = 7) and the Asia-Pacific (n = 6 programs) in 2012. Patient-level data were collected on 1002 adult TB patients seen at 40 of the participating ART programs.RESULTS: Phenotypic drug susceptibility testing (DST) was available in 36 (77%) ART programs, but was only used for 22% of all TB patients. Molecular DST was available in 33 (70%) programs and was used in 23% of all TB patients. Twenty ART programs (43%) provided directly observed therapy (DOT) during the entire course of treatment, 16 (34%) during the intensive phase only, and 11 (23%) did not follow DOT. Fourteen (30%) ART programs reported no access to second-line anti-tuberculosis regimens; 18 (38%) reported TB drug shortages.CONCLUSIONS: Capacity to diagnose and treat drug-resistant TB was limited across ART programs in lower-income countries. DOT was not always implemented and drug supplies were regularly interrupted, which may contribute to the global emergence of drug resistance.
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- 2014
6. [ Helicobacter pylori infection: prevalence and associated factors in a study population undergoing Carbon-14 urea breath test].
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Kpossou AR, Kouwakanou HB, Ahouada C, Vignon RK, Sokpon CNM, Zoundjiekpon V, Kodjoh N, and Séhonou J
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- Adult, Breath Tests, Carbon Radioisotopes, Humans, Male, Middle Aged, Prevalence, Prospective Studies, Urea analysis, Helicobacter Infections complications, Helicobacter Infections diagnosis, Helicobacter Infections epidemiology, Helicobacter pylori
- Abstract
Introduction: Helicobacter pylori (H. pylori) infection is common in developing countries such as Benin. This germ may cause the development of gastroduodenal diseases, ranging from gastritis to gastric cancer. Several studies on this bacterium carried out in Benin have used serology, anatomopathological examination of biopsies or antigen detection test on stool sample collections. The purpose of this study was to assess the prevalence of H. pylori infection and factors associated with H. pylori infection using a respiratory test. The bacterium could cause chronic inflammation of the gastric mucosa and peptic ulcer disease or, more rarely, gastric cancer or lymphoma., Methods: we conducted a prospective, descriptive study of 150 patients who performed carbon-14 urea breath test. Only patients admitted for respiratory test and who gave their consent were included. A survey was completed by all patients during the study. Simple univariate logistic regression analysis identified factors associated with H. pylori infection at a threshold of 0.05. Multivariate analysis included in the model all variables with a p-value less than 0.20. Manual top-down procedure was used until the final model was obtained, which allowed the retention of adjusted odds ratios for factors associated., Results: the average age of patients was 44.4±15.8 years, ranging from 5 to 84 years; men accounted for 54% of the study population. Of the 150 subjects, 82 (57.8%) had higher education level, compared with 8 (5.6%) who were not educated, 116 (80.6%) lived with a partner, 24 (36%) lived in a room with more than 10 people and 84 (59.6%) were christians. The main reasons why respiratory tests were performed were: poorly systematized abdominal pain (53.3%; 70/150), epigastric induced pain (35.3%; 53/150), epigastralgia (20.7%; 31/150), ulcer syndrome (16%; 24/150). Respiratory test showed that the prevalence of H. pylori in the study population was 34.7% (52/150). In multivariate analysis, the variables significantly associated with H. pylori infection were: mean age [aOR (95% CI) = 1.02; OR (95% CI) = 1.00-1.05 and p = 0.01] and prior treatment for H. pylori eradication [aOR (95% CI) = 4.79; OR (95% CI) = 1.50-13.86 and p = 0.006]. No comorbidity was associated with H. pylori infection in our series., Conclusion: the prevalence of H. pylori using this method was low (34.7%). It was significantly associated with mean age and prior treatment for H. pylori eradication., Competing Interests: Les auteurs ne déclarent aucun conflit d'intérêts., (Copyright: Aboudou Raïmi Kpossou et al.)
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- 2021
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7. [Seroprevalence of hepatitis C virus (HCV) antibodies and associated factors based on voluntary screening data collection in the general population in Benin in 2016].
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Kpossou AR, Kouwakanou B, Sokpon CNDM, Alassane KS, Bankolé MM, Ahouada C, Vignon RK, Zoundjiekpon V, Sourokou F, Séhonou J, and Kodjoh N
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- Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Alcoholism epidemiology, Benin epidemiology, Child, Child, Preschool, Cross-Sectional Studies, Female, Hepatitis C diagnosis, Humans, Infant, Infant, Newborn, Male, Middle Aged, Risk Factors, Seroepidemiologic Studies, Young Adult, Hepatitis C epidemiology, Hepatitis C Antibodies blood, Mass Screening methods
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Introduction: hepatitis C is a public health problem worldwide, in particular in sub-Saharan Africa. The purpose of this study is to determine the seroprevalence of hepatitis C virus antibodies and associated factors during a voluntary general population screening program in Benin., Method: we conducted a descriptive and analytical cross-sectional study in 4 big cities of 4 different departments in Benin in July 2016. All volunteers of all ages, residing in these targeted cities, who gave their informed consent were included in the study. ImuMed HCV Rapid Diagnostic Test (Healgen Scientific LLC, USA) was used. Logistic regression analysis was also used to identify factors associated with hepatitis C virus infection., Results: a total of 2809 volunteers with an average age of 25.9 ± 16.5 years (ranging from 0 to 86 years) were included in the study; 53.9% (1514/2809) of them were men and 46.1% (1295/2809) were women. More than half of the study population consisted of single (59.1%; 1612/2726); 41.3% (1074/2809) were pupils or students. VHC Seroprevalence was 1.5% (42/2809). In multivariate analysis, the variables significantly associated with anti-HCV carriage were: be 60 years old and older (aOR: 46.9, 95% CI 10.2-216.0; p<0.0001) and a history of alcoholism (aOR: 6.3; 95% CI 95% 3.3-12.1; p < 0.0001)., Conclusion: in the general population, the seroprevalence of anti-HCV antibodies was 1.5%. HCV infection mainly occurred in people aged 60 years and older and in those with a history of alcoholism., Competing Interests: Les auteurs ne déclarent aucun conflit d'intérêts., (Copyright: Aboudou Raïmi Kpossou et al.)
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- 2021
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8. Pre-exposure prophylaxis among men who have sex with men in Côte d'Ivoire: a quantitative study of acceptability.
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Diabaté S, Kra O, Biékoua YJ, Pelletier SJ, Osso DG, Diané B, N'Dhatz-Ebagnitchié M, Ahouada C, Kobena AK, and Alary M
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- Adult, Coitus, Cote d'Ivoire, Cross-Sectional Studies, Homosexuality, Male, Humans, Male, HIV Infections prevention & control, Pre-Exposure Prophylaxis, Sexual and Gender Minorities
- Abstract
This cross sectional study was conducted in 2018 in Côte d'Ivoire to assess PrEP acceptability among men who have sex with men (MSM). Two hundred and one men were asked on their intention to use PrEP if made available. Logistic regression accounting for the sampling design was used to analyze associations between high PrEP acceptability and different independent variables including barriers and facilitators. Participants were mostly young (mean age = 25 years), educated (82% with secondary/postsecondary education) and single (95.5%). On average, 3.4 episodes of anal sex were reported monthly and 37.8% of men did not use a condom at last sex. Most MSM (72.6%) had heard of PrEP before enrollment. Overall, 35.3% reported that they would use PrEP very probably if made available. In multivariate analysis, factors associated with high PrEP acceptability were condom use at last sexual intercourse (Odds ratio (OR) = 2.51; 95%Confidence interval (95%CI) = 1.45-4.33); insertive sex as compared to versatile sex (OR = 2.56; 95%CI = 1.14-5.67); free PrEP delivery (OR = 2.45; 95%CI = 1.07-5.59), concerns about side effects (OR = 0.66; 95%CI = 0.48-0.90), and being preoccupied by the fact that post-PrEP antiretroviral therapy could be inefficient (OR = 0.25; 95%CI = 0.14-0.44). PrEP implementation among MSM in Côte d'Ivoire should be accompanied by awareness raising campaigns explaining its utility.
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- 2021
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9. Acceptability of pre-exposure prophylaxis for HIV prevention: facilitators, barriers and impact on sexual risk behaviors among men who have sex with men in Benin.
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Ahouada C, Diabaté S, Mondor M, Hessou S, Guédou FA, Béhanzin L, Batona G, Gning NN, Zannou DM, and Alary M
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- Adolescent, Adult, Benin, Cities, Condoms, Cross-Sectional Studies, Emtricitabine therapeutic use, Health Services Accessibility, Humans, Logistic Models, Male, Middle Aged, Odds Ratio, Risk-Taking, Safe Sex, Sexual Behavior, Sexual and Gender Minorities, Tenofovir therapeutic use, Young Adult, Anti-HIV Agents therapeutic use, HIV Infections prevention & control, Homosexuality, Male, Patient Acceptance of Health Care, Pre-Exposure Prophylaxis methods
- Abstract
Background: In Benin, men who have sex with men (MSM) do not always use condoms during anal sex. Pre-exposure prophylaxis (PrEP) using Truvada® (tenofovir disoproxil fumarate / emtricitabine) may be a complementary HIV prevention measure for MSM. This study aimed at identifying the potential facilitators and barriers to the use of PrEP., Methods: This was a cross-sectional study conducted in 2018 among male-born MSM aged 18 years or older who reported being HIV-negative or unaware of their HIV status. The participants were recruited by the RDS technique (respondent driven sampling) in six cities of Benin. Logistic regression analyses, adapted to RDS statistical requirements, were performed to identify the factors associated with PrEP acceptability., Results: Mean age of the 400 MSM recruited was 26.2 ± 5.0 years. PrEP was known by 50.7% of respondents. The intention to use PrEP was expressed by 90% of MSM. If PrEP effectiveness were 90% or more, 87.8% of the respondents thought they would decrease condom use. In multivariate analysis, the facilitators associated with PrEP acceptability were: not having to pay for PrEP (odds ratio (OR) = 2.39, 95% CI: 1.50-4.46) and its accessibility within MSM networks (OR = 9.82, 95% CI: 3.50-27.52). Only one barrier was significant: the concern that taking PrEP be perceived as marker of adopting HIV risky behaviors (OR = 0.11, 95% CI: 0.04-0.30)., Conclusion: In Benin, not all MSM know about PrEP. But once well informed, the majority seems willing to use it if made available. The free availability of the drug and its accessibility in the MSM networks are important facilitators. The possibility of decrease in condom use should not be a barrier to the prescription of PrEP if made available.
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- 2020
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10. Acceptability of pre-exposure prophylaxis (PrEP) among men who have sex with men (MSM) in Benin: a qualitative study.
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Ahouada C, Diabaté S, Gning NN, Hessou S, Batona G, Guédou FA, Béhanzin L, Zannou MD, and Alary M
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- Adult, Anti-HIV Agents therapeutic use, Benin, Focus Groups, HIV Infections psychology, Homosexuality, Male ethnology, Humans, Male, Middle Aged, Patient Acceptance of Health Care ethnology, Qualitative Research, Safe Sex, Sexual Behavior, Anti-HIV Agents administration & dosage, HIV Infections prevention & control, Homosexuality, Male psychology, Patient Acceptance of Health Care psychology, Pre-Exposure Prophylaxis methods
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In Benin, consistent condom use among men who have sex with men (MSM) is relatively low and providing them with Pre-exposure prophylaxis (PrEP) could be of great relevance. We aimed to describe PrEP knowledge and intention to use it; identify key facilitators and barriers to PrEP; and describe the perceived impact of PrEP on unsafe sexual behavior. MSM, 18 years or older, HIV-negative or of unknown status, were enrolled in five cities of Benin. Intention to use PrEP was assessed through five focus groups (FG). Data were analyzed using manual thematic sorting. Thirty MSM (six per city) participated in the FG. Mean age (standard deviation) was 27.1 (5.0) years. All participants expressed the intention to use PrEP if made available. Facilitators of PrEP use were: availability of medication, safety, absence of constraints as well as freedom to have multiple sex partners and sex with HIV-positive friends. Barriers were: complex procedures for obtaining medication, size and taste of medication, cost of medication, poor PrEP awareness.. Eighteen men admitted that PrEP could lead to decrease in or even abandonment of condom use. In conclusion, MSM showed openness to use PrEP if available, although they recognized that it could lead to risk compensation.
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- 2020
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11. Impact of Pre-antiretroviral Therapy CD4 Counts on Drug Resistance and Treatment Failure: A Systematic Review.
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Diallo M, Adekpedjou R, Ahouada C, Ngangue P, and Ly BA
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- Drug Resistance, Viral, Humans, Risk Factors, Treatment Failure, Anti-HIV Agents therapeutic use, CD4 Lymphocyte Count, HIV Infections drug therapy
- Abstract
The continuous rising of HIV drug resistance in low- and middle-income countries and its impact on treatment failure is a growing threat for the HIV treatment response. This review aimed to document pre-antiretroviral therapy (ART) CD4 counts, emerging drug resistance, and treatment failure in HIV-infected individuals initiating ART. We performed an online search in PubMed, Embase, Web of Science, African Index Medicus, Cochrane library, and The National Institute for Health Clinical Trials Registry of relevant articles published from January 1996 to June 2019. Of 1755 original studies retrieved, 28 were retained for final analysis. Treatment failure varied between 5% (95% confidence interval [CI]: 2.7-7.4) and 72% (95% CI: 55-89.6), while resistance varied between 1% (95% CI: 0.47-1.5) and 48% (95% CI: 28.4-67.6). Participants with a pre-ART CD4 count below 200 cell/μl and low adherence showed higher percentages of resistance and failure, while those with CD4 count above 200 showed lower resistance and failure regardless adherence levels. Most frequent resistance mutations included the M184I/V for the nucleoside reverse-transcriptase inhibitors (NRTIs), K103N, and Y181 for the non-NRTIs (NNRTIs), and L90M for the Protease inhibitors. Pre-ART CD4 count and adherence to treatment could play a key role in reducing drug resistance and treatment failure. The increased access to ART in resources limited settings should be accompanied by regular CD4 count testing, drug resistance monitoring, and continuous promotion of adherence. In addition, the rising of resistance mutations associated with NRTIs and NNRTIs, suggest that alternative ART regimens should be considered. (AIDS Rev. 2020;22:
-0)., (Copyright: © 2020 Permanyer.) - Published
- 2020
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12. Comparison of the prevalence rates of HIV infection between men who have sex with men (MSM) and men in the general population in sub-Saharan Africa: a systematic review and meta-analysis.
- Author
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Hessou PHS, Glele-Ahanhanzo Y, Adekpedjou R, Ahouada C, Johnson RC, Boko M, Zomahoun HTV, and Alary M
- Subjects
- Acquired Immunodeficiency Syndrome epidemiology, Adult, Africa South of the Sahara epidemiology, Humans, Male, Prevalence, HIV Infections epidemiology, Homosexuality, Male statistics & numerical data
- Abstract
Background: According to the 2015 report of the Joint United Nations Program on Human Immunodeficiency Virus (HIV) and Acquired Immune Deficiency Syndrome (AIDS), the prevalence rates of HIV infection among men who have sex with men (MSM) varied from 6 to 37% depending on the country, far exceeding the national prevalence rates. The present study on HIV infection among men who have sex with men in sub-Saharan Africa was conducted to describe the different sampling methods used to identify this target population and compare the prevalence rates of HIV infection among MSM to that of men in the general population., Methods: The selection of studies to be included was carried out in the principal electronic databases. The 2009 Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) directives were used throughout the entire process. Bias evaluation was performed using the Mixed Methods Appraisal Tool. For each country, HIV prevalence values in both groups were calculated. A prevalence ratio was also calculated to compare the prevalence rates of the two groups., Results: Seventeen articles were selected. Most of the studies (82.35%) used the Respondent-Driven Sampling method. The average prevalence rate was 17.81% (range: 3.7-33.46) for MSM and 6.15% (range: 0.5-19.7) for men in the general population. Overall, the human HIV prevalence rate was 4.94 times higher among MSM than among men in the general population (95%CI: 2.91-8.37). The western and central regions of Africa, as well as low-prevalence countries (prevalence < 1%), had very high prevalence ratios: 14.47 (95% CI: 9.90-21.13) and 28.49 (95% CI: 11.47-72.71), respectively., Conclusion: MSM are at higher risk of HIV infection than men in the general population. The prevalence ratios are particularly elevated in West and Central Africa as well as in low-prevalence countries. Close monitoring of the situation, research and preventive measures are essential to control the epidemic amongst MSM.
- Published
- 2019
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13. [Prevalence and factors associated with cryptococcal antigenemia in HIV-infected patients in Cotonou/Benin].
- Author
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Ogouyèmi-Hounto A, Zannou DM, Ayihounton G, Ahouada C, Azon-Kouanou A, Acakpo J, Sissinto Savi de Tove Y, and Kinde Gazard D
- Subjects
- AIDS-Related Opportunistic Infections blood, AIDS-Related Opportunistic Infections epidemiology, Adult, Benin epidemiology, CD4 Lymphocyte Count, Cross-Sectional Studies, Cryptococcosis complications, Female, HIV Infections complications, HIV-1, Humans, Male, Meningitis, Cryptococcal blood, Meningitis, Cryptococcal complications, Meningitis, Cryptococcal epidemiology, Middle Aged, Pilot Projects, Prevalence, Risk Factors, Antigens, Fungal blood, Cryptococcosis blood, Cryptococcosis epidemiology, Cryptococcus immunology, HIV Infections blood, HIV Infections epidemiology
- Abstract
Objective: Determine the prevalence of cryptococcal antigenemia and associated factors in HIV-infected patients in Cotonou in order to introduce systematic screening in national guidelines., Patients and Methods: This is a cross-sectional, descriptive and analytical study conducted from June to September 2015 in four outpatient treatment centers with adult patients infected with HIV, receiving or not antiretroviral treatment with a number of CD4≤200cell/μL and who have given their informed consent to participate in the study. For each enrolled patient, after signing the informed consent form, it was made a clinical examination and administration of a questionnaire to collect general information, treatment and biological data. Then a blood sample for counting CD4 lymphocytes and the search of cryptococcal antigenemia were done., Results: In total, 355 patients were included in the study with a mean age of 40±10.2years. The overall prevalence of cryptococcal antigenemia is 1.7%. All patient with cryptococcal antigenemia have a CD4 count below 100cells/μL with a majority having CD4 count below 50cells/μL. Body mass index<18.5kg/m
2 , an alteration of the general condition with a CD4 lymphocyte counts<50cells/μL are the main factors associated with the occurrence of cryptococcal antigenemia., Conclusion: This pilot study showed a low prevalence of cryptococcal antigenemia in the study population, but higher in highly immuno-deficient patients with CD4 counts<50cells/μl. Given the results obtained, the introduction of routine screening among patients infected with HIV could be reserved to those with CD4 counts<50cells/μl., (Copyright © 2016 Elsevier Masson SAS. All rights reserved.)- Published
- 2016
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14. Severe morbidity after antiretroviral (ART) initiation: active surveillance in HIV care programs, the IeDEA West Africa collaboration.
- Author
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Abo Y, Zannou Djimon M, Messou E, Balestre E, Kouakou M, Akakpo J, Ahouada C, de Rekeneire N, Dabis F, Lewden C, and Minga A
- Subjects
- Adult, Ambulatory Care Facilities, Anti-HIV Agents therapeutic use, Benin epidemiology, Cooperative Behavior, Cote d'Ivoire epidemiology, Data Collection, Databases, Factual, Female, Fever epidemiology, HIV Infections drug therapy, Hospitalization statistics & numerical data, Humans, Karnofsky Performance Status, Male, Middle Aged, Morbidity, Prospective Studies, Severity of Illness Index, AIDS-Related Opportunistic Infections epidemiology, HIV Infections epidemiology, Malaria epidemiology, Pneumonia epidemiology, Tuberculosis epidemiology
- Abstract
Background: The causes of severe morbidity in health facilities implementing Antiretroviral Treatment (ART) programmes are poorly documented in sub-Saharan Africa. We aimed to describe severe morbidity among HIV-infected patients after ART initiation, based on data from an active surveillance system established within a network of specialized care facilities in West African cities., Methods: Within the International epidemiological Database to Evaluate AIDS (IeDEA)--West Africa collaboration, we conducted a prospective, multicenter data collection that involved two facilities in Abidjan, Côte d'Ivoire and one in Cotonou, Benin. Among HIV-infected adults receiving ART, events were recorded using a standardized form. A simple case-definition of severe morbidity (death, hospitalization, fever>38°5C, Karnofsky index<70%) was used at any patient contact point. Then a physician confirmed and classified the event as WHO stage 3 or 4 according to the WHO clinical classification or as degree 3 or 4 of the ANRS scale., Results: From December 2009 to December 2011, 978 adults (71% women, median age 39 years) presented with 1449 severe events. The main diagnoses were: non-AIDS-defining infections (33%), AIDS-defining illnesses (33%), suspected adverse drug reactions (7%), other illnesses (4%) and syndromic diagnoses (16%). The most common specific diagnoses were: malaria (25%), pneumonia (13%) and tuberculosis (8%). The diagnoses were reported as syndromic in one out of five events recorded during this study., Conclusions: This study highlights the ongoing importance of conventional infectious diseases among severe morbid events occurring in patients on ART in ambulatory HIV care facilities in West Africa. Meanwhile, additional studies are needed due to the undiagnosed aspect of severe morbidity in substantial proportion.
- Published
- 2015
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15. Characteristics of HIV-2 and HIV-1/HIV-2 Dually Seropositive Adults in West Africa Presenting for Care and Antiretroviral Therapy: The IeDEA-West Africa HIV-2 Cohort Study.
- Author
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Ekouevi DK, Balestre E, Coffie PA, Minta D, Messou E, Sawadogo A, Minga A, Sow PS, Bissagnene E, Eholie SP, Gottlieb GS, Dabis F, Zannou DM, Ahouada C, Akakpo J, Ahomadegbé C, Bashi J, Gougounon-Houéto A, Azon-Kouanou A, Houngbé F, Koumakpaï S, Alihonou F, d'Almeida M, Hodonou I, Hounhoui G, Sagbo G, Tossa-Bagnan L, Adjide H, Drabo J, Bognounou R, Dienderé A, Traore E, Zoungrana L, Zerbo B, Sawadogo AB, Zoungrana J, Héma A, Soré I, Bado G, Tapsoba A, Yé D, Kouéta F, Ouedraogo S, Ouédraogo R, Hiembo W, Gansonré M, Messou E, Gnokoro JC, Koné M, Kouakou GM, Bosse CA, Brou K, Assi AI, Chenal H, Hawerlander D, Soppi F, Minga A, Abo Y, Bomisso G, Eholié SP, Amego MD, Andavi V, Diallo Z, Ello F, Tanon AK, Koule SO, Anzan KC, Guehi C, Aka EA, Issouf KL, Kouakou JC, N'gbeche MS, Touré P, Avit-Edi D, Kouakou K, Moh M, Yao VA, Folquet MA, Dainguy ME, Kouakou C, Méa-Assande VT, Oka-Berete G, Zobo N, Acquah P, Kokora MB, Eboua TF, Timité-Konan M, Ahoussou LD, Assouan JK, Sami MF, Kouadio C, Renner L, Goka B, Welbeck J, Sackey A, Owiafe SN, Wejse C, Silva ZJ, Paulo J, Rodrigues A, da Silva D, Medina C, Oliviera-Souto I, Ostergaard L, Laursen A, Sodemann M, Aaby P, Fomsgaard A, Erikstrup C, Eugen-Olsen J, Maïga MY, Diakité FF, Kalle A, Katile D, Traore HA, Minta D, Cissé T, Dembelé M, Doumbia M, Fomba M, Kaya AS, Traoré AM, Traoré H, Toure AA, Dicko F, Sylla M, Berthé A, Traoré HC, Koïta A, Koné N, N'diaye C, Coulibaly ST, Traoré M, Traoré N, Charurat M, Ajayi S, Dapiap S, Otu, Igbinoba F, Benson O, Adebamowo C, James J, Obaseki, Osakede P, Olasode J, Sow PS, Diop B, Manga NM, Tine JM, Signate Sy H, Ba A, Diagne A, Dior H, Faye M, Gueye RD, Mbaye AD, Patassi A, Kotosso A, Kariyare BG, Gbadamassi G, Komi A, Mensah-Zukong KE, Pakpame P, Lawson-Evi AK, Atakouma Y, Takassi E, Djeha A, Ephoévi-Gah A, Djibril Sel-H, Dabis F, Bissagnene E, Arrivé E, Coffie P, Ekouevi D, Jaquet A, Leroy V, Lewden C, Sasco A, Azani JC, Allou G, Balestre E, Bohossou F, Karcher S, Gonsan JM, Carrou JL, Lenaud S, Nchot C, Malateste K, Yao AR, Siloué B, Clouet G, Djetouan H, Doring A, Kouakou A, Rabourdin E, Rivenc J, Anglaret X, Ba B, Essanin JB, Ciaranello A, Datté S, Desmonde S, Diby JS, Gottlieb GS, Horo AG, Kangah SN, Malvy D, Meless D, Mounkaila-Harouna A, Ndondoki C, Shiboski C, Thiébaut R, Pac-Ci, and Abidjan
- Subjects
- Adult, Africa, Western epidemiology, Cohort Studies, Female, HIV Infections virology, Humans, Male, Middle Aged, Anti-HIV Agents therapeutic use, HIV Infections drug therapy, HIV-1 isolation & purification, HIV-2 isolation & purification
- Abstract
Background: HIV-2 is endemic in West Africa. There is a lack of evidence-based guidelines on the diagnosis, management and antiretroviral therapy (ART) for HIV-2 or HIV-1/HIV-2 dual infections. Because of these issues, we designed a West African collaborative cohort for HIV-2 infection within the framework of the International epidemiological Databases to Evaluate AIDS (IeDEA)., Methods: We collected data on all HIV-2 and HIV-1/HIV-2 dually seropositive patients (both ARV-naive and starting ART) and followed-up in clinical centres in the IeDEA-WA network including a total of 13 clinics in five countries: Benin, Burkina-Faso Côte d'Ivoire, Mali, and Senegal, in the West Africa region., Results: Data was merged for 1,754 patients (56% female), including 1,021 HIV-2 infected patients (551 on ART) and 733 dually seropositive for both HIV-1 and HIV 2 (463 on ART). At ART initiation, the median age of HIV-2 patients was 45.3 years, IQR: (38.3-51.7) and 42.4 years, IQR (37.0-47.3) for dually seropositive patients (p = 0.048). Overall, 16.7% of HIV-2 patients on ART had an advanced clinical stage (WHO IV or CDC-C). The median CD4 count at the ART initiation is 166 cells/mm(3), IQR (83-247) among HIV-2 infected patients and 146 cells/mm(3), IQR (55-249) among dually seropositive patients. Overall, in ART-treated patients, the CD4 count increased 126 cells/mm(3) after 24 months on ART for HIV-2 patients and 169 cells/mm(3) for dually seropositive patients. Of 551 HIV-2 patients on ART, 5.8% died and 10.2% were lost to follow-up during the median time on ART of 2.4 years, IQR (0.7-4.3)., Conclusions: This large multi-country study of HIV-2 and HIV-1/HIV-2 dual infection in West Africa suggests that routine clinical care is less than optimal and that management and treatment of HIV-2 could be further informed by ongoing studies and randomized clinical trials in this population.
- Published
- 2013
- Full Text
- View/download PDF
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