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1. Substrate specificity and excision kinetics of Escherichia coli endonuclease VIII (Nei) for modified bases in DNA damaged by free radicals

Author

Dizdaroglu, Miral, Burgess, Sarah M., Jugara, Pawel, Hazra, Tapas K., Rodriguez, Henry, and Lloyd, R. Stephen

Subjects
Biochemistry -- Research, Escherichia coli -- Physiological aspects, DNA damage -- Research, Radicals (Chemistry) -- Physiological aspects, Oxidation-reduction reaction -- Physiological aspects, Biological sciences, Chemistry
Abstract

Research has been conducted on the endonuclease VIII of Escherichia coli involved in the base-excision repair of DNA oxidative damage. The substrate specificity and excision kinetics of this DNA glycosylase for the DNA bases damaged by the free radicals have been investigated and the results are reported.

Published
2001

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