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Substrate specificity and excision kinetics of Escherichia coli endonuclease VIII (Nei) for modified bases in DNA damaged by free radicals

Authors :
Dizdaroglu, Miral
Burgess, Sarah M.
Jugara, Pawel
Hazra, Tapas K.
Rodriguez, Henry
Lloyd, R. Stephen
Source :
Biochemistry. Oct 9, 2001, Vol. 40 Issue 40, p12150, 7 p.
Publication Year :
2001

Abstract

Research has been conducted on the endonuclease VIII of Escherichia coli involved in the base-excision repair of DNA oxidative damage. The substrate specificity and excision kinetics of this DNA glycosylase for the DNA bases damaged by the free radicals have been investigated and the results are reported.

Subjects

Subjects :
Biochemistry -- Research
Escherichia coli -- Physiological aspects
DNA damage -- Research
Radicals (Chemistry) -- Physiological aspects
Oxidation-reduction reaction -- Physiological aspects
Biological sciences
Chemistry

Details

ISSN :
00062960
Volume :
40
Issue :
40
Database :
Gale General OneFile
Journal :
Biochemistry
Publication Type :
Academic Journal
Accession number :
edsgcl.79835064

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