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5. Transplantation pulmonaire en France : actualisation des indications et contre-indications en 2022

Author

Le Pavec, J., Pison, C., Hirschi, S., Bunel, V., Mordant, P., Brugière, O., Le Guen, M., Olland, A., Coiffard, B., Renaud-Picard, B., Tissot, A., Brioude, G., Borie, R., Crestani, B., Deslée, G., Stelianides, S., Mal, H., Schuller, A., Falque, L., Lorillon, G., Tazi, A., Burgel, P.R., Grenet, D., De Miranda, S., Bergeron, A., Launay, D., Cottin, V., Nunes, H., Valeyre, D., Uzunhan, Y., Prévot, G., Sitbon, O., Montani, D., Savale, L., Humbert, M., Fadel, E., Mercier, O., Mornex, J.F., Dauriat, G., and Reynaud-Gaubert, M.

Published
2022
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7. Impact de la période périopératoire sur le pronostic de la transplantation pulmonaire chez les patients ayant des dilatations des bronches non liées à la mucoviscidose

Author

Decaux, S., primary, Roux, A., additional, Mal, H., additional, Glorion, M., additional, Miranda (de), S., additional, Sage, E., additional, Bunel, V., additional, Castier, Y., additional, Roussel, A., additional, Montravers, P., additional, Mordant, P., additional, and Messika, J., additional

Published
2024
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10. (1224) Peripheral Vesicular-Bound Hla-g as Predictor of Graft Tolerance after Lung Transplantation

Author

Brugiere, O., primary, Dreyfuss, D., additional, Guilet, R., additional, Hirschi, S., additional, Renaud-Picard, B., additional, Reynaud-Gaubert, M., additional, Nieves, A., additional, Bunel, V., additional, Messika, J., additional, Demant, X., additional, Jérôme, L., additional, Dauriat, G., additional, Saint-Raymond, C., additional, Falque, L., additional, Mornex, J., additional, Tissot, A., additional, Foureau, A., additional, Leborgne-Krams, A., additional, Boussaud, V., additional, MAgnan, A., additional, Picard, C., additional, Roux, A., additional, Carosella, E. Edgardo, additional, Vallée, A., additional, Freiss, R. Rouas, additional, and MAoult, J. Le, additional

Published
2023
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15. Impact of Candida spp. contamination of preservation solutions in lung transplantation: a national experience over a 10-year period

Author

Noret, C, primary, Bretonnière, C, additional, Morio, F, additional, Degot, T, additional, Bru, V, additional, Picard, C, additional, Cardot, E, additional, Coiffard, B, additional, Ranque, S, additional, Falque, L, additional, Cornet, M, additional, Gazengel, P, additional, Gigandon, A, additional, Senechal, A, additional, Menotti, J, additional, Bunel, V, additional, Bonnal, C, additional, Leborgne, A, additional, Cassaing, S, additional, Demant, X, additional, Gabriel, F, additional, Dannaoui, E, additional, Blanc, F, additional, and Tissot, A, additional

Published
2022
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23. Évolution après transplantation pulmonaire des patients adultes atteints d’une pneumopathie interstitielle diffuse dans un contexte de mutation d’un gène codant pour une protéine du surfactant

Author

Bermudez, J., primary, Nathan, N., additional, Coiffard, B., additional, Roux, A., additional, Hirschi, S., additional, Degot, T., additional, Bunel, V., additional, Le Pavec, J., additional, Macey, J., additional, Le Borgne, A., additional, Legendre, M., additional, Cottin, V., additional, Thomas, P., additional, Borie, R., additional, and Reynaud-Gaubert, M., additional

Published
2022
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25. Patients candidats à la transplantation pulmonaire récusés pour motifs psycho-sociaux : une étude monocentrique

Author

Medraoui, C., primary, Bouchez, C., additional, Jebrak, G., additional, Godet, C., additional, Bunel, V., additional, Weisenburger, G., additional, Goletto, T., additional, Salpin, M., additional, Mouren, D., additional, Thibaut De Ménonville, C., additional, Mordant, P., additional, Tran-Dinh, A., additional, Gounant, V., additional, Mal, H., additional, and Messika, J., additional

Published
2022
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27. Infinitix-BOS Trial: Multi-Center, Randomised, Double-Blind Placebo-Controlled Trial of Nintedanib in Lung Transplant Recipients with Bronchiolitis Obliterans Syndrome (BOS) Grade 0-p and Grade 1-2

Author

Brugiere, O., primary, Picard, C., additional, Messika, J., additional, Weisenburger, G., additional, Bunel, V., additional, Demant, X., additional, Bon, c., additional, Macey, C., additional, Le Pavec, J., additional, Dauriat, G., additional, Crutu, A., additional, Hirschi, S., additional, Renaud Picard, b., additional, Degot, T., additional, Reynaud-Gaubert, M., additional, Coiffard, B., additional, Coltey, B., additional, Pison, C., additional, Raymond, C. Saint, additional, Briault, a., additional, Hamid, A., additional, Beaumont, L., additional, and Roux, A., additional

Published
2021
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28. Antifibrosants: risque post-opératoire chez les patients transplantés pour une fibrose pulmonaire idiopathique

Author

Moncomble, E., primary, Weisenburger, G., additional, Picard, C., additional, Degot, T., additional, Reynaud-Gaubert, M., additional, Nieves, A., additional, Mornex, J.F., additional, Dauriat, G., additional, Messika, J., additional, Godet, C., additional, Hirschi, S., additional, Le Pavec, J., additional, Borie, R., additional, Mordant, P., additional, Mal, H., additional, and Bunel, V., additional

Published
2021
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31. Essai multicentrique, randomisé double aveugle contre placebo, évaluant l’efficacité du Nintedanib dans le traitement du syndrome de bronchiolite oblitérante grade 0-p et grade 1-2 chez les patients transplantés pulmonaires

Author

Brugière, O., primary, Couffignal, C., additional, Maurer, Y., additional, Messika, J., additional, Weisenburger, G., additional, Bunel, V., additional, Demant, X., additional, Bon, C., additional, Macey, C., additional, Le Pavec, J., additional, Dauriat, G., additional, Crutu, A., additional, Hirschi, S., additional, Renaud-Picard, B., additional, Degot, T., additional, Reynaud-Gaubert, M., additional, Coltey, B., additional, Pison, C., additional, Saint Raymond, C., additional, Briot, A., additional, Makhlouf, S., additional, Beaumont, L., additional, Picard, C., additional, and Antoine, R., additional

Published
2021
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32. Progression rapide de la fibrose du poumon natif associée à une infection virale sévère après transplantation monopulmonaire pour fibrose

Author

Goletto, T., primary, Decaux, S., additional, Bunel, V., additional, Weisenburger, G., additional, Messika, J., additional, Najem, S., additional, Medraoui, C., additional, Godet, C., additional, Mordant, P., additional, Castier, Y., additional, Bouadma, L., additional, Borie, R., additional, and Mal, H., additional

Published
2021
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33. Cohorte nationale sur l’utilisation du céfiderocol

Author

Bleibtreu, A., primary, Dortet, L., additional, Razazi, K., additional, Bunel, V., additional, Dupont, H., additional, Sacleux, S., additional, Wyplosz, B., additional, Siméon, S., additional, Tattevin, P., additional, and Dinh, A., additional

Published
2020
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34. Characteristics, Survival, and Outcomes of Lung and Heart-Lung Transplantation for Pulmonary Sarcoidosis in a Multicenter European Study Characteristics, Survival, and Outcomes of Lung and Heart-Lung Transplantation for Pulmonary Sarcoidosis in a Multicenter European Study

Author

Pavec, J. Le, primary, Gazengel, P., additional, Valeyre, D., additional, Schultz, H., additional, Magnusson, J., additional, Godinas, L., additional, Hirschi, S., additional, Bunel, V., additional, Picard, C., additional, Reynaud-Gaubert, M., additional, Mornex, J., additional, Blanchard, E., additional, Leborgne, A., additional, Harari, S., additional, Tissot, A., additional, Knoop, C., additional, Savale, L., additional, Fadel, E., additional, and Gottlieb, J., additional

Published
2020
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36. Diagnosis of Restrictive Allograft Syndrome (RAS) in Single-Lung Transplantation Using PFTs and CT-Scan Volumetry and Score

Author

Brugiere, O., primary, Philippot, Q., additional, Bun, R., additional, Couffignal, C., additional, Frijat, J., additional, Bunel, V., additional, Morer, L., additional, Mourin, G., additional, Jebrak, G., additional, Castier, Y., additional, Dauriat, G., additional, Mordant, P., additional, Mal, H., additional, and Debray, M., additional

Published
2019
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37. Difficultés diagnostiques du syndrome restrictif du greffon (RAS) après greffe mono-pulmonaire : caractérisation de l’évolution fonctionnelle, scanographique et immunologique au sein d’une série de 17 patients

Author

Philippot, Q., primary, Debray, M.P., additional, Bun, R., additional, Couffignal, C., additional, Frija, J., additional, Bunel, V., additional, Morer, L., additional, Mourin, G., additional, Marceau, A., additional, Jebrak, G., additional, Mal, H., additional, and Brugière, O., additional

Published
2019
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39. Airway microbiota signals anabolic and catabolic remodeling in the transplanted lung

Author

Mouraux, Stéphane, primary, Bernasconi, Eric, additional, Pattaroni, Céline, additional, Koutsokera, Angela, additional, Aubert, John-David, additional, Claustre, Johanna, additional, Pison, Christophe, additional, Royer, Pierre-Joseph, additional, Magnan, Antoine, additional, Kessler, Romain, additional, Benden, Christian, additional, Soccal, Paola M., additional, Marsland, Benjamin J., additional, Nicod, Laurent P., additional, Jougon, J., additional, Velly, J.-F., additional, Rozé, H., additional, Blanchard, E., additional, Dromer, C., additional, Antoine, M., additional, Cappello, M., additional, Ruiz, M., additional, Sokolow, Y., additional, Vanden Eynden, F., additional, Van Nooten, G., additional, Barvais, L., additional, Berré, J., additional, Brimioulle, S., additional, De Backer, D., additional, Créteur, J., additional, Engelman, E., additional, Huybrechts, I., additional, Ickx, B., additional, Preiser, T.J.C., additional, Tuna, T., additional, Van Obberghe, L., additional, Vancutsem, N., additional, Vincent, J.-L., additional, De Vuyst, P., additional, Etienne, I., additional, Féry, F., additional, Jacobs, F., additional, Knoop, C., additional, Vachiéry, J.L., additional, Van den Borne, P., additional, Wellemans, I., additional, Amand, G., additional, Collignon, L., additional, Giroux, M., additional, Angelescu, D., additional, Chavanon, O., additional, Hacini, R., additional, Pirvu, A., additional, Porcu, P., additional, Albaladejo, P., additional, Allègre, C., additional, Bataillard, A., additional, Bedague, D., additional, Briot, E., additional, Casez-Brasseur, M., additional, Colas, D., additional, Dessertaine, G., additional, Durand, M., additional, Francony, G., additional, Hebrard, A., additional, Marino, M.R., additional, Oummahan, B., additional, Protar, D., additional, Rehm, D., additional, Robin, S., additional, Rossi-Blancher, M., additional, Augier, C., additional, Bedouch, P., additional, Boignard, A., additional, Bouvaist, H., additional, Briault, A., additional, Camara, B., additional, Claustre, J., additional, Chanoine, S., additional, Dubuc, M., additional, Quétant, S., additional, Maurizi, J., additional, Pavèse, P., additional, Pison, C., additional, Saint-Raymond, C., additional, Wion, N., additional, Chérion, C., additional, Grima, R., additional, Jegaden, O., additional, Maury, J.-M., additional, Tronc, F., additional, Flamens, C., additional, Paulus, S., additional, Mornex, J.-F., additional, Philit, F., additional, Senechal, A., additional, Glérant, J.-C., additional, Turquier, S., additional, Gamondes, D., additional, Chalabresse, L., additional, Thivolet-Bejui, F., additional, Barnel, C., additional, Dubois, C., additional, Tiberghien, A., additional, Le Pimpec-Barthes, F., additional, Bel, A., additional, Mordant, P., additional, Achouh, P., additional, Boussaud, V., additional, Guillemain, R., additional, Méléard, D., additional, Bricourt, M.O., additional, Cholley, B., additional, Pezella, V., additional, Brioude, G., additional, D'Journo, X.B., additional, Doddoli, C., additional, Thomas, P., additional, Trousse, D., additional, Dizier, S., additional, Leone, M., additional, Papazian, L., additional, Bregeon, F., additional, Basire, A., additional, Coltey, B., additional, Dufeu, N., additional, Dutau, H., additional, Garcia, S., additional, Gaubert, J.Y., additional, Gomez, C., additional, Laroumagne, S., additional, Nieves, A., additional, Picard, L.C., additional, Reynaud-Gaubert, M., additional, Secq, V., additional, Mouton, G., additional, Baron, O., additional, Lacoste, P., additional, Perigaud, C., additional, Roussel, J.C., additional, Danner, I., additional, Haloun, A., additional, Magnan, A., additional, Tissot, A., additional, Lepoivre, T., additional, Treilhaud, M., additional, Botturi-Cavaillès, K., additional, Brouard, S., additional, Danger, R., additional, Loy, J., additional, Morisset, M., additional, Pain, M., additional, Pares, S., additional, Reboulleau, D., additional, Royer, P.-J., additional, Fabre, D., additional, Fadel, E., additional, Mercier, O., additional, Mussot, S., additional, Stephan, F., additional, Viard, P., additional, Cerrina, J., additional, Dorfmuller, P., additional, Ghigna, S.M., additional, Hervén, Ph., additional, Le Roy Ladurie, F., additional, Le Pavec, J., additional, Thomas de Montpreville, V., additional, Lamrani, L., additional, Castier, Y., additional, Cerceau, P., additional, Augustin, P., additional, Jean-Baptiste, S., additional, Boudinet, S., additional, Montravers, P., additional, Brugière, O., additional, Dauriat, G., additional, Jébrak, G., additional, Mal, H., additional, Marceau, A., additional, Métivier, A.-C., additional, Thabut, G., additional, Lhuillier, E., additional, Dupin, C., additional, Bunel, V., additional, Falcoz, P., additional, Massard, G., additional, Santelmo, N., additional, Ajob, G., additional, Collange, O., additional, Helms, O., additional, Hentz, J., additional, Roche, A., additional, Bakouboula, B., additional, Degot, T., additional, Dory, A., additional, Hirschi, S., additional, Ohlmann-Caillard, S., additional, Kessler, L., additional, Kessler, R., additional, Schuller, A., additional, Bennedif, K., additional, Vargas, S., additional, Stauder, J., additional, Ali-Azouaou, S., additional, Bonnette, P., additional, Chapelier, A., additional, Puyo, P., additional, Sage, E., additional, Bresson, J., additional, Caille, V., additional, Cerf, C., additional, Devaquet, J., additional, Dumans-Nizard, V., additional, Felten, M.-L., additional, Fischler, M., additional, Si Larbi, A.-G., additional, Leguen, M., additional, Ley, L., additional, Liu, N., additional, Trebbia, G., additional, De Miranda, S., additional, Douvry, B., additional, Gonin, F., additional, Grenet, D., additional, Hamid, A.M., additional, Neveu, H., additional, Parquin, F., additional, Picard, C., additional, Roux, A., additional, Stern, M., additional, Bouillioud, F., additional, Cahen, P., additional, Colombat, M., additional, Dautricourt, C., additional, Delahousse, M., additional, D'Urso, B., additional, Gravisse, J., additional, Guth, A., additional, Hillaire, S., additional, Honderlick, P., additional, Lequintrec, M., additional, Longchampt, E., additional, Mellot, F., additional, Scherrer, A., additional, Temagoult, L., additional, Tricot, L., additional, Vasse, M., additional, Veyrie, C., additional, Zemoura, L., additional, Berjaud, J., additional, Brouchet, L., additional, Dahan, M., additional, Mathe, F.O., additional, Benahoua, H., additional, DaCosta, M., additional, Serres, I., additional, Merlet-Dupuy, V., additional, Grigoli, M., additional, Didier, A., additional, Murris, M., additional, Crognier, L., additional, Fourcade, O., additional, Krueger, T., additional, Ris, H.B., additional, Gonzalez, M., additional, Jolliet, Ph., additional, Marcucci, C., additional, Chollet, M., additional, Gronchi, F., additional, Courbon, C., additional, Berutto, C., additional, Manuel, O., additional, Koutsokera, A., additional, Aubert, J.-D., additional, Nicod, L.P., additional, Mouraux, S., additional, Bernasconi, E., additional, Pattaroni, C., additional, Marsland, B.J., additional, Soccal, P.M., additional, Rochat, T., additional, Lücker, L.M., additional, Hillinger, S., additional, Inci, I., additional, Weder, W., additional, Schuepbach, R., additional, Zalunardo, M., additional, Benden, C., additional, Schuurmans, M.M., additional, Gaspert, A., additional, Holzmann, D., additional, Müller, N., additional, Schmid, C., additional, Vrugt, B., additional, Fritz, A., additional, Maier, D., additional, Deplanche, K., additional, Koubi, D., additional, Ernst, F., additional, Paprotka, T., additional, Schmitt, M., additional, Wahl, B., additional, Boissel, J.-P., additional, Olivera-Botello, G., additional, Trocmé, C., additional, Toussaint, B., additional, Bourgoin-Voillard, S., additional, Sève, M., additional, Benmerad, M., additional, Siroux, V., additional, Slama, R., additional, Auffray, C., additional, Charron, D., additional, Lefaudeux, D., additional, and Pellet, J., additional

Published
2018
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41. Role of Complement-Binding Anti-HLA Antibodies Detection as Early Predictor of Chronic Lung Dysfunction After Lung Transplantation

Author

Brugière, O., primary, Roux, A., additional, Le Pavec, J., additional, Sroussi, D., additional, Parquin, F., additional, Pradère, P., additional, Dupin, C., additional, Bunel, V., additional, Mourin, G., additional, Jebrak, G., additional, Thabut, G., additional, Dauriat, G., additional, Castier, Y., additional, Mordant, P., additional, Lortat Jacob, B., additional, Jean-Baptiste, S., additional, Mal, H., additional, Suberbielle, C., additional, and Taupin, J., additional

Published
2017
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42. Blood CD9+B cell, a biomarker of bronchiolitis obliterans syndrome after lung transplantation

Author

Brosseau, Carole, Danger, Richard, Durand, Maxim, Durand, Eugénie, Foureau, Aurore, Lacoste, Philippe, Tissot, Adrien, Roux, Antoine, Reynaud‐Gaubert, Martine, Kessler, Romain, Mussot, Sacha, Dromer, Claire, Brugière, Olivier, Mornex, Jean François, Guillemain, Romain, Claustre, Johanna, Magnan, Antoine, Brouard, Sophie, Jougon, J., Velly, J.‐F., Rozé, H., Blanchard, E., Antoine, M., Cappello, M., Ruiz, M., Sokolow, Y., Vanden Eynden, F, Van Nooten, G., Barvais, L., Berré, J., Brimioulle, S., De Backer, D., Créteur, J., Engelman, E, Huybrechts, I., Ickx, B., Preiser, T.J.C., Tuna, T., Van Obberghe, L., Vancutsem, N., Vincent, J.‐L., De Vuyst, P., Etienne, I., Féry, F., Jacobs, F., Knoop, C., Vachiéry, J.L., Van den Borne, P., Wellemans, I., Amand, G., Collignon, L., Giroux, M., Angelescu, D., Chavanon, O., Hacini, R., Martin, C., Pirvu, A., Porcu, P., Albaladejo, P., Allègre, C., Bataillard, A., Bedague, D., Briot, E., Casez‐Brasseur, M., Colas, D., Dessertaine, G., Francony, G., Hebrard, A., Marino, M.R., Protar, D., Rehm, D., Robin, S, Rossi‐Blancher, M., Augier, C., Bedouch, P., Boignard, A., Bouvaist, H., Briault, A., Camara, B., Chanoine, S., Dubuc, M., Quétant, S., Maurizi, J., Pavèse, P., Pison, C., Saint‐Raymond, C., Wion, N., Chérion, C., Grima, R., Jegaden, O., Maury, J.‐M., Tronc, F., Flamens, C., Paulus, S., Philit, F., Senechal, A., Glérant, J.‐C., Turquier, S., Gamondes, D., Chalabresse, L., Thivolet‐Bejui, F., Barnel, C., Dubois, C., Tiberghien, A., Pimpec‐Barthes, F., Bel, A., Mordant, P., Achouh, P., Boussaud, V., Méléard, D., Bricourt, M.O., Cholley, B., Pezella, V., Brioude, G., D'Journo, X.B., Doddoli, C., Thomas, P., Trousse, D., Dizier, S., Leone, M., Papazian, L., Bregeon, F., Coltey, B., Dufeu, N., Dutau, H., Garcia, S., Gaubert, J.Y., Gomez, C., Laroumagne, S., Mouton, G., Nieves, A., Picard, Ch., Rolain, J.M., Sampol, E., Secq, V., Perigaud, C., Roussel, J.C., Senage, T., Mugniot, A., Danner, I., Haloun, A., Abbes, S., Bry, C., Blanc, F.X., Lepoivre, T., Botturi‐Cavaillès, K., Loy, J., Bernard, M., Godard, E., Royer, P.‐J., Henrio, K., Dartevelle, Ph., Fabre, D., Fadel, E., Mercier, O., Stephan, F., Viard, P., Cerrina, J., Dorfmuller, P., Feuillet, S., Ghigna, M., Hervén, Ph., Le Roy Ladurie, F., Le Pavec, J., Thomas de Montpreville, V., Lamrani, L., Castier, Y., Mordant, P., Cerceau, P., Augustin, P., Jean‐Baptiste, S., Boudinet, S., Montravers, P., Dauriat, G., Jébrak, G., Mal, H., Marceau, A., Métivier, A.‐C., Thabut, G., Lhuillier, E., Dupin, C., Bunel, V., Falcoz, P., Massard, G., Santelmo, N., Ajob, G., Collange, O., Helms, O., Hentz, J., Roche, A., Bakouboula, B., Degot, T., Dory, A., Hirschi, S., Ohlmann‐Caillard, S., Kessler, L., Schuller, A., Bennedif, K., Vargas, S., Bonnette, P., Chapelier, A., Puyo, P., Sage, E., Bresson, J., Caille, V., Cerf, C., Devaquet, J., Dumans‐Nizard, V., Felten, M.L., Fischler, M., Si Larbi, A.G., Leguen, M., Ley, L., Liu, N., Trebbia, G., De Miranda, S., Douvry, B., Gonin, F., Grenet, D., Hamid, A.M., Neveu, H., Parquin, F., Picard, C., Stern, M., Bouillioud, F., Cahen, P., Colombat, M., Dautricourt, C., Delahousse, M., D'Urso, B., Gravisse, J., Guth, A., Hillaire, S., Honderlick, P., Lequintrec, M., Longchampt, E., Mellot, F., Scherrer, A., Temagoult, L., Tricot, L., Vasse, M., Veyrie, C., Zemoura, L., Dahan, M., Murris, M., Benahoua, H., Berjaud, J., Le Borgne Krams, A., Crognier, L., Brouchet, L., Mathe, O., Didier, A., Krueger, T., Ris, H.B., Gonzalez, M., Aubert, J.‐D., Nicod, L.P., Marsland, B.J., Berutto, T.C., Rochat, T., Soccal, P., Jolliet, Ph., Koutsokera, A., Marcucci, C., Manuel, O., Bernasconi, E., Chollet, M., Gronchi, F., Courbon, C., Hillinger, S., Inci, I., Kestenholz, P., Weder, W., Schuepbach, R., Zalunardo, M., Benden, C., Buergi, U., Huber, L.C., Isenring, B., Schuurmans, M.M., Gaspert, A., Holzmann, D., Müller, N., Schmid, C., Vrugt, B., Rechsteiner, T., Fritz, A., Maier, D., Deplanche, K., Koubi, D., Ernst, F., Paprotka, T., Schmitt, M., Wahl, B., Boissel, J.‐P., Olivera‐Botello, G., Trocmé, C., Toussaint, B., Bourgoin‐Voillard, S., Séve, M., Benmerad, M., Siroux, V., Slama, R., Auffray, C., Charron, D., Lefaudeux, D., and Pellet, J.

Abstract

Bronchiolitis obliterans syndrome is the main limitation for long‐term survival after lung transplantation. Some specific B cell populations are associated with long‐term graft acceptance. We aimed to monitor the B cell profile during early development of bronchiolitis obliterans syndrome after lung transplantation. The B cell longitudinal profile was analyzed in peripheral blood mononuclear cells from patients with bronchiolitis obliterans syndrome and patients who remained stable over 3 years of follow‐up. CD24hiCD38hitransitional B cells were increased in stable patients only, and reached a peak 24 months after transplantation, whereas they remained unchanged in patients who developed a bronchiolitis obliterans syndrome. These CD24hiCD38hitransitional B cells specifically secrete IL‐10 and express CD9. Thus, patients with a total CD9+B cell frequency below 6.6% displayed significantly higher incidence of bronchiolitis obliterans syndrome (AUC = 0.836, PPV = 0.75, NPV = 1). These data are the first to associate IL‐10‐secreting CD24hiCD38hitransitional B cells expressing CD9 with better allograft outcome in lung transplant recipients. CD9‐expressing B cells appear as a contributor to a favorable environment essential for the maintenance of long‐term stable graft function and as a new predictive biomarker of bronchiolitis obliterans syndrome–free survival. In lung transplant patients with bronchiolitis obliterans syndrome and patients who remained stable over 3 years of follow‐up, IL‐10–secreting CD24hiCD38hi transitional B cells expressing CD9 are associated with better allograft outcome, suggesting CD9‐expressing B cells as a new predictive biomarker of bronchiolitis obliterans syndrome–free survival.

Published
2019
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44. Enquête sur la physiologie respiratoire et les internes en pneumologie

Author

Patout, M., primary, Coiffard, B., additional, Sésé, L.-C., additional, Korzeniewski, S., additional, Bunel, V., additional, Luchez, A., additional, Desseigne, M., additional, Emery, M., additional, Lhuillier, E., additional, Salvator, H., additional, Matecki, S., additional, Perez, T., additional, Chambellan, A., additional, De Jesus, A.-M., additional, Gille, T., additional, Tardif, C., additional, Pradel, A.-F., additional, Straus, C., additional, Thiberville, L., additional, and Didier, A., additional

Published
2015
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46. Traitement de 1religne

Author

Bunel, V. and Berghmans, T.

Abstract

Plus de 85 % des patients présentant un carcinome bronchique non à petites cellules (CBNPC) n’ont pas de mutation activatrice pour l’EGFR. Leur prise en charge en première ligne est donc le quotidien des médecins s’intéressant aux cancers bronchiques. La chimiothérapie a montré son utilité en comparaison des soins de confort depuis de nombreuses années. La chimiothérapie de référence doit être une polychimiothérapie à base de sels de platine, en privilégiant le cisplatine si l’état du patient et ses comorbidités le permettent. Une bithérapie plutôt qu’une monothérapie est bénéfique, y compris chez les patients âgés ou en mauvais état général. En cas de contre-indication au cisplatine, une bithérapie avec ou sans carboplatine peut être utilisée. Le choix du second agent s’associant au cisplatine doit être guidé par les effets secondaires attendus et par l’histologie. Les stratégies reposant sur la présence d’une suractivation de certaines protéines (ERCC1 par exemple) n’ont pas prouvé leur efficacité. À part l’adjonction de bevacizumab à une bithérapie, il n’y a pour l’instant pas de place pour les thérapies ciblées en première ligne de traitement des CBNPC.

Published
2014
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48. Peripheral Vesicular-Bound Hla-g as Predictor of Graft Tolerance after Lung Transplantation.

Author

Brugiere, O., Dreyfuss, D., Guilet, R., Hirschi, S., Renaud-Picard, B., Reynaud-Gaubert, M., Nieves, A., Bunel, V., Messika, J., Demant, X., Jérôme, L., Dauriat, G., Saint-Raymond, C., Falque, L., Mornex, J., Tissot, A., Foureau, A., Leborgne-Krams, A., Boussaud, V., and MAgnan, A.

Subjects
*LUNG transplantation, *HISTOCOMPATIBILITY class I antigens, *GEL permeation chromatography
Abstract

Survival after lung transplantation (LTx) still remains limited by chronic lung allograft dysfunction (CLAD). Prior studies showed an association between graft cellular expression of the checkpoint HLA-G and acceptance, whereas conversely, soluble HLA-G (sHLA-G) in plasma/BAL was associated with acute rejection. We investigated whether plasma levels of extra-vesicular (EVs)-bound HLA-G could predict CLAD. We used data for 79 LTx recipients from COLT (Cohort For Lung Transplantation) cohortwith ≥1 available blood samples at 6-, or 12-months post-Tx, all with a stable function within the 1st year. Among them, 41 developed subsequent CLAD (Group CLAD=33 BOS and 8 RAS) and 38 remained STABLE at 3 years. 20 heathy individuals (HI) were negative controls. EVs from plasma were isolated by size exclusion chromatography and characterized by nanoparticule tracking analysis. Plasma levels of EVs-bound HLA-G (sHLA-G EV) and of total soluble-HLA-G (sHLA-G TOT =sHLA-G EV + free sHLA-G) were measured by ELISA. Uni- and multivariate were performed to assess association of EVs levels and CLAD/survival. In stable patients, mean plasma levels of sHLA-G EV at M6 and M12, were significantly increased as compared to those of HI (M6: 30.2 vs 15,1 ng/mL, p=0.008, and M12: 37.8 vs 15.1 ng/mL, p=0.0009, respectively). In BOS patients, a decreased plasma levels of sHLA-G EV were observed at M6 and M12 as compared to stable patients, with a significant difference at M12 (mean sHLA-G EV of 23.7 ng/mL vs 38.7 p=0.02). In those BOS patients, sHLA-G EV levels remained increased as compared to HI at M6 (p=0.01). In RAS patients, sHLA- GEV levels was similar to stable patients at M6 and M12, and increased as compared to HI (M12: 40,5 vs 15,6 ng/mL, p=0.004). Among the whole cohort, a higher freedom from CLAD was observed in patients with sHLA-G EV level > first IQR (=21.3 g/ml) at M12 post-LTx (p=0.01, Figure 1). Our data suggest that an early decrease of sHLA-G EV levels after LTx may be predictive of subsequent CLAD onset. [ABSTRACT FROM AUTHOR]

Published
2023
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50. An underrecognized phenotype of pulmonary emphysema with marked pulmonary gas exchange but with mild or moderate airway obstruction.

Author

Weisenburger G, Bunel V, Godet C, Salpin M, Mouren D, Menonville CT, Goletto T, Marceau A, Borie R, Debray MP, and Mal H

Abstract

In patients with pulmonary emphysema and mild to moderate airflow limitation, one does not expect the features marked exertional dyspnea and hypoxemia as well as a profound decrease in diffusing capacity of the lung for carbon monoxide (DLCO). Here we describe this phenotype and its prognosis. From our database, we retrospectively selected cases associating emphysema, exertional breathlessness, O 2 requirement at least upon exercise, forced expiratory volume in 1 sec (FEV 1 ) ≥ 50% predicted, and DLCO ≤ 50% predicted, without associated combined pulmonary fibrosis and emphysema, right-to-left shunt, or severe pulmonary hypertension. Over a 12-year period, we identified 16 patients with emphysema and the above presentation. At the initial evaluation, the median age was 62 years (interquartile range 53.8-68.9). The median FEV 1 and DLCO% predicted and mean pulmonary artery pressure were 86 (65-95)%, 38 (31-41)%, and 20 (17-25) mm Hg, respectively. On room air, the median arterial partial pressure of oxygen and partial pressure of carbon dioxide in arterial blood were 63.5 (55.8-69) mm Hg and 34.5 (31-36) mm Hg with increased median alveolar-arterial oxygen difference (46 [39-51] mm Hg). After the initial evaluation, the respiratory condition worsened in 13 of 14 (92.8%) patients with one or more re-evaluations (median follow-up 2.6 [0.9-5.8] years). In 12, lung transplantation was considered. Four patients died after 5.8, 5.7, 7.1, and 0.8 years of follow-up, respectively. We describe an underrecognized phenotype of pulmonary emphysema featuring a particular profile characterized by marked exertional dyspnea, impaired pulmonary gas exchange with low DLCO and marked oxygen desaturation at least on exercise but with mild or moderate airway obstruction., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024. Published by Elsevier Masson SAS.)

Published
2024
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