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1. Chromatographic Methods for the Determination of Rifampicin, Isoniazid, Pyrazinamide, Ethambutol, and Main Metabolites in Biological Samples: A Review.

Author

Brozyna-Heredia IY, Ganoza-Yupanqui ML, Moreno-Exebio L, and Dos Santos JL

Subjects
Humans, Chromatography, Liquid methods, Antitubercular Agents analysis, Antitubercular Agents pharmacokinetics, Antitubercular Agents blood, Antitubercular Agents metabolism, Isoniazid analysis, Isoniazid pharmacokinetics, Isoniazid metabolism, Isoniazid blood, Pyrazinamide analysis, Pyrazinamide pharmacokinetics, Pyrazinamide metabolism, Pyrazinamide blood, Ethambutol analysis, Ethambutol blood, Ethambutol pharmacokinetics, Ethambutol metabolism, Rifampin analysis, Rifampin pharmacokinetics, Rifampin metabolism
Abstract

Bioanalytical methods are used to quantify drugs and their metabolites in biological samples in order to determine bioequivalence, perform pharmacokinetic and bioavailability studies, and complete therapeutic drug monitoring. The objective of this review paper is to describe bioanalytical methods based on Liquid Chromatography that are used to quantify antitubercular drugs and their metabolites in different biological samples, utilizing scientific literature from 1992 to 2021.

Published
2024
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