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Aim: Diabetes Mellitus (DM) is associated with an higher incidence of many forms of cancer, while DFS is characterized by high cardiovascular mortality and morbidity, but its propensity to cancer has not be ascertained so far. Our Aim was to measure the prevalence of cancer in DFS and check for possible associations between the two conditions. Method: we retrospectively searched the databases of our Department for all the consecutive patients admitted in the Medical department of our hospital between January of 2019 and December of 2021 with a admission diagnosis of DM with (DFS+) or without (DFS-) DFS. We compared the prevalence of cancer between the groups and we checked for possible correlations between the two conditions not influenced by other known possible predictors (familiariaty, age, sex, smoking, rena insufficiency, anaemia). Results / Discussion: Comprehensively 222 DFS + and 223 DFS - controls were studied. Overall cancer prevalence was 15.3% and in DFS+ was significantly higher than both DM (11.7% p=0.008) and controls (13.3%, p=0.031). Univariate regression showed a significant association between cancer and DF ( p = 0.007), age at admission(p = < 0.001), years of diabetes(p = 0.017) and hemoglobin(p = 0.03). At multivariate regression only DF(p=0.021), and age at admission (p < 0.001) persisted as independent predictors. Conclusion: DFS is characterized by a higher prevalence of cancer compared to both DM patients and non diabetic controls and can be considered as an independent risk factor for neoplasms. [ABSTRACT FROM AUTHOR]

Aim: Diabetic Foot Syndrome (DFS) is associated with a high risk of cardiovascular morbidity and major amputation (MA). Likewise, cancer is a well-established risk for cardiovascular disease. Our aim was to assess if DFS patients with cancer have a worse cardiovascular profile and surgical outcomes compared to DFS patients without cancer. Method: We retrospectively analyzed the charts data of 223 consecutive DFS patients [M:166/F:57, age: 69.6±10.4,T2DM 94.66%/T1DM 5.4%] admitted between January 2019 and December 2021 in our Department for interventional procedures (Revascularization and/or foot surgery). Prevalence of cancer, cardiovascular pathologies, MA and re-intervention were derivated. Results / Discussion: Cancer was observed in 47 (21.1%) DFS patients. Patients with cancer were older (71.5 vs 68 yrs, p<0.01) and with a longer history of diabetes (24.5 vs 19 yrs,p<0.05). Major cardiovascular events, atrial fibrillation and renal failure prevalence didn't differ between patients with and without cancer. After a median time of 5 months, reoperation was performed in 35.4% of patients, without any difference between cancer+ and cancer- DFS. Globally, MA prevalence was 9.6%. Although, MA prevalence did not differ between patients with and without cancer, patients with blood cancer (n=9) showed a higher prevalence of MA than those with solid tumors (33.3% vs 5.1%, p<0.05) and those without cancer (9.7%, p<0.05). Conclusion: Cardiovascular profile, surgical outcome and reoperation rate didn't differ between DFS patients with and without cancer. More studies are needed to confirm that DFS patients with blood tumors could present higher risk of MA. [ABSTRACT FROM AUTHOR]