104 results on '"Breast Hyperplasia"'
Search Results
2. Study on the potential mechanism of Pu Gong Ying in treating breast hyperplasia based on network pharmacology and molecular docking.
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Zhiyong Sun, Shuli Gao, Yang Zhang, Gangqiang Xue, Zilin Yuan, and Shaonan Wang
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MOLECULAR pharmacology , *MOLECULAR docking , *HYPERPLASIA , *PROTEIN-protein interactions , *CELLULAR signal transduction - Abstract
In the present study, network pharmacology was employed to elucidate the targets and pathways involved in the treatment of breast hyperplasia (BH) by Pu Gong Ying (PGY). Molecular docking was utilized to analyze the interaction between PGY and key targets based on the findings of network pharmacology. The intersection of 261 targets associated with 15 PGY compounds and 2455 targets related to BH yielded 90 common targets (89 of which were included in the protein-protein interaction (PPI) network, while one target did not exhibit interactions with any other targets in the PPI network). The top 10 hub targets ranked in the PPI network and the top 10 targets according to the Molecular Complex Detection (MOCDE) score were intersected, resulting in the identification of CASP3, EGFR, ESR1, ERBB2, MMP9, and PTGS2 as key targets, as determined by different algorithms. Gene Ontology (GO) functional enrichment analysis revealed 284 biological components. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis identified 125 pathways, primarily associated with the regulation of pathways in cancer, the PI3K-Akt signaling pathway, the MAPK signaling pathway, microRNAs in cancer, chemical carcinogenesis-receptor activation, and others. Molecular docking results demonstrated the favorable binding efficacy of PGY9, PGY10, and PGY11 with the core targets. The findings suggested that PGY exerted its therapeutic effects on BH through multiple targets and biological pathways. This study contributed to the understanding of the molecular mechanisms underlying BH development and provided implications for BH-targeted therapy and even breast cancer prevention. [ABSTRACT FROM AUTHOR]
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- 2023
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3. Current Status of Mongolian Medicine Treatment for Breast Hyperplasia.
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Tseber and Sarangerel
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ORAL drug administration , *CHINESE medicine , *MEDICAL research , *HYPERPLASIA , *ACUPUNCTURE - Abstract
Through literature and clinical research, the current status of Mongolian medicine treatment for breast hyperplasia is discussed, such as oral administration of Mongolian medicine for treatment, oral administration of Mongolian medicine combined with external application for treatment, combination of Mongolian medicine acupuncture therapy and oral administration of Mongolian medicine for treatment, integrated treatment of Mongolian and Western medicine, and combination therapy of Mongolian and traditional Chinese medicine, providing new ideas and choices for clinical research. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Breast Anomalies: Diagnosis and Treatment
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Ribeiro, Ricardo Cavalcanti, Hanke, Carlos José Ramírez, de Córdova, Luis Fernandez, Avelar, Juarez Moraes, editor, and Cavalcanti Ribeiro, Ricardo, editor
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- 2023
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5. Cutaneous Disorders of the Breast
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Ranawaka, Ranthilaka Rasika, Madarasinghe, Nayani P., Kannangara, Ajith Prasanna, de Silva, Kanishka, Smoller, Bruce, editor, and Bagherani, Nooshin, editor
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- 2022
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6. Research on the Mechanism of Xiaoyao Pill in Treating Hyperplasia of Mammary Gland was Explored Based on Network Pharmacology and Molecular Docking Technology
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GUAN Qing-xia, YANG Fang-fang, YANG Zhi-ping, NIE Ze-hui, ZHOU Xiao-ying, LIN Ze-yu, CHEN Zhong-xin, and ZOU Shu-jun
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network pharmacology ,xiaoyao pill ,breast hyperplasia ,the key targets ,molecular docking ,Food processing and manufacture ,TP368-456 ,Nutrition. Foods and food supply ,TX341-641 - Abstract
The objective of this research is to study the mechanism of Xiaoyao pill in the treatment of breast hyperplasia by using network pharmacological formula. The active components of Xiaoyao pill were collected and screened in the Pharmacological Database and Analysis Platform of Chinese Medicine (TCMSP), and the included compounds were predicted by TCMSP database. GeneCards database, NCBI gene database and OMIM database were used for screening of breast hyperplasia disease targets. The drug targets and disease targets were selected to make a Venn diagram, and the common targets were used to make a PPI network diagram in the String database. Topological analysis and MCODE cluster analysis were used to screen the core targets and core genes. The key active ingredients were screened in Cytoscape 3.8.0 software. The STRING database was used for GO analysis and KEGG analysis for key targets, and the relevant results were imported into Cytoscape 3.8.0 to draw the component-disease-path path-target network diagram. The active components and targets of Xiaoyao Pills were screened, among which 169 targets were related to breast hyperplasia. Stat3, Akt1, MAPK1, Jun, MAPK3 and other 20 targets were the key targets of this drug in the treatment of breast hyperplasia, and HTR2A, IL2, TOP2A, PCNA, MMP1 were the core genes of this drug in the treatment of breast hyperplasia. Quercetin, Kaempferol, luteolin, naringenin, licochalcone A, 7-methoxy-2-methyl isoflavone, formononetin, and acacetin may be the main active components of Xiaoyao Pill in the treatment of breast hypertrophy. A total of 2328 biological processes were enriched by GO enrichment analysis, with 160 molecular function correlations and 47 cell composition correlations. Enrichment analysis showed that it was associated with 166 pathways, including AGE-RAGE signaling pathway, TNF signaling pathway, IL-17 signaling pathway, Th17 cell differentiation, fluid shear stress and atherosclerosis signaling pathway. The molecular docking verification results showed that the key active ingredients and core targets were well docking. From the perspective of network pharmacology, the potential mechanism and pharmacological substance basis of Xiaoyao pill in the treatment of breast hyperplasia are preliminarily revealed, providing ideas for the follow-up research on Xiaoyao pill in the treatment of gynecological diseases.
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- 2022
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7. Current trends in breast reduction: an international analysis.
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Broer, Peter Niclas, Forte, Antonio Jorge, Topka, Charlotte, Richter, Dirk Frank, Colombo, Martin, Aung, Thiha, Prantl, Lukas, Ninkovic, Milomir, Rohrich, Rodney James, and Heidekrueger, Paul Immanuel
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PLASTIC surgeons , *BREAST surgery , *OPERATIVE surgery , *SURGEONS - Abstract
Background: Breastand reductions mastopexies continue to rank among the most frequently performed plastic surgical procedures worldwide. While there exists a consensus on several aspects of the procedure, a plethora of controversies remain. This study aims to compare the most relevant peri- and intra-operative factors on an international level to standardize this common procedure according to evidence-based guidelines. Methods: A questionnaire was sent to over five thousand surgeons in 77 countries. The survey was divided into three categories according to the volume of removed breast tissue (50–500 g, 500–1000 g, and > 1000 g) and inquired about standard practices, secondary procedures, use of new technologies, current controversies, and surgeon demographics. The results were evaluated and correlated with evidence-based literature. Results: A total of 1431 surveys were gathered, corresponding to a response rate of 29%. It was found that specific surgical approaches and standard practices prevail on an international basis. Still, there exist controversies that seem to be linked to geographic locations. For instance, irrespective of resection weight, in the majority of countries, a superior or superomedial pedicle is used most frequently, while in North America and South East Asia, the inferior-based pedicle is preferred. Conclusions: We identified common traits in several aspects of breast reduction surgery. However, in this study, it became apparent that international practice patterns remain incoherent. Seen from a global perspective, plastic surgeons would thus still benefit from high-quality studies to further establish evidence-based, standardized, and universally applicable practice guidelines. Level of Evidence: Not gradable [ABSTRACT FROM AUTHOR]
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- 2022
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8. 基于网络药理学与分子对接技术探究逍遥丸治疗乳腺增生的作用机制.
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管庆霞, 杨芳芳, 杨志平, 聂泽卉, 周小影, 林泽榆, 陈忠新, and 邹淑君
- Abstract
Copyright of Science & Technology of Cereals, Oils & Foods is the property of Science & Technology of Cereals, Oils & Foods Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2022
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9. The Clinical Application Value of RDW, CA153, and MPV in Breast Cancer.
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Fengke Lu, Siqiong Pan, Yunwei Qi, Xi Li, and Jian Wang
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BREAST cancer ,MEAN platelet volume ,ERYTHROCYTES - Abstract
Background: Early detection of tumors is beneficial to the treatment of patients. Certain indicators in the blood routine, such as red blood cell distribution width (RDW), are considered to be used to assess the patient's condition and prognosis. Mean platelet volume (MPV) is also used to assess the prognosis of patients. Carbohydrate antigen 153 (CA153) is considered to be a more specific antigen marker for breast cancer. The purpose of our study was to explore the diagnostic value of RDW, MPV, and CA153 for breast cancer (BC) and breast hyperplasia (BH). Methods: The study included 104 breast cancer patients, 100 breast hyperplasia patients, and 100 healthy controls. CA153 was detected by an automatic electrochemical luminescence analyzer (Cobas e601, Roche Diagnostics, Switzerland). The concentration of RDW and MPV in serum was measured by Sysmex XN-10-B3 (Sysmex, Japan). Results: Compared with the breast hyperplasia group, the RDW and CA153 of the breast cancer group were increased. The healthy control group, mammary gland hyperplasia group, and breast cancer were positively correlated with RDW and CA153. Logistic regression results show that increasing age, increasing RDW, and increasing CA153 can increase the risk of breast cancer. The area under the ROC (AUC) analysis showed that the combined specificity and sensitivity of the combined application of RDW, MPV, and CA153 for the identification of breast cancer is better than that of a single marker. Conclusions: The combined application of RDW, MPV, and CA153 can improve the differential diagnosis of breast cancer and breast hyperplasia. [ABSTRACT FROM AUTHOR]
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- 2021
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10. Management of recurrent bilateral multifocal pseudoangiomatous stromal hyperplasia (PASH).
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Xu, Xiaolu, Persing, Sarah M., Allam, Omar, Park, Kitae E., Mozaffari, Mohammad Ali, Lannin, Donald R., Bossuyt, Veerle, and Alperovich, Michael
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HYPERPLASIA , *BREAST diseases , *MAMMAPLASTY , *MASTECTOMY , *PUERPERIUM - Abstract
Pseudoangiomatous stromal hyperplasia (PASH) is a benign hyperplastic condition of the breast that can lead to macromastia. The standard treatment for PASH is focal excision or rarely reduction mammoplasty. We present a rare case of postpartum bilateral rapid breast enlargement and axillary growth that was refractory to reduction mammoplasty. Ultimately, the patient required bilateral mastectomy and two‐stage implant‐based breast reconstruction. This more extensive form along with its management represents one of the few reported cases in the literature. The decision to pursue bilateral mastectomy was undertaken after exhausting more conservative options. Excellent aesthetic outcome and pain relief was obtained following definitive extirpative and reconstructive surgery. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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11. 乳康胶囊治疗乳腺增生的临床疗效及对血清激素水平的影响.
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徐晓燕 and 乔华
- Abstract
Objective To observe clinical effects of Rukang capsule in the treatment of breast hyperplasia and its effect on serum hormone levels. Methods All 195 patients with breast hyperplasia who were treated in the outpatient department of Galacto-phore in Gansu Wuxvei Tumour Hospital from January and December 2017 were randomly allocated to the observation group(99 cases) and the control group!96 cases). The observation group took Rukang capsule,and the control group took Guizhifulin capsule. Both groups were treated for 3 months consecutively. Serum progesterone(P), prolactin!PRL) and estradiol! E2) were detected,and clinical effects were observed. Results Total effective rate of the observation group was 89.9%(89/99), higher than 78.1%(75/96)of the control group, the difference was statistically significant (P<0.05). Compared with before treatment. the serum E2 and PRL level were significantly reduced in both groups, and the serum P level increased significantly, the differences were statistically significant (P<0.05). Compared with the control group after treatment. the serum E2 and PRL level decreased significantly, and the serum P level increased significantly, the differences were statistically significant (P <0.05). Conclusion Rukang capsule can gain notable clinical effects in treating breast hyperplasia. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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12. Avaliação das principais patologias relacionadas ao uso de contraceptivos em felinos e seus efeitos deletérios
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Francisco Lima Silva, Catarina Rafaela Alves da Silva, Luciana Rangélia Malvina Souza de Castro, Wanderson Gabriel Gomes de Melo, Artur Oliveira Rocha, Aline Carvalho Araújo, Kelline Emanuelle da Rocha Rodrigues, Thanisya Kelly de Paiva Brito, Eglesia Rodrigues Leite Fernandes, and Tairine Melo Costa
- Subjects
Gynecology ,medicine.medical_specialty ,piometra ,lcsh:Veterinary medicine ,business.industry ,fármacos contraceptivos ,Breast Hyperplasia ,neoplasia mamária ,Contraceptive drugs ,General Medicine ,Pyometra ,Abortion ,medicine.disease ,Breast cancer ,medicine ,hiperplasia mamária ,lcsh:SF600-1100 ,business ,aborto - Abstract
Com a crescente urbanização e individualidade social há o aumento da criação com guarda responsável de animais de estimação, com principais exemplares os cães e gatos, este último como preferencial pelos tutores de forma ascendente nos últimos anos. Naturalmente os felinos podem ter até três gestações no período de um ano, com variação de um a nove filhotes em cada uma delas. Desta forma, a superpopulação destes animais ocorre de maneira exponencial. Esta característica, leva os proprietários a procurar por formas de contracepção para os animais. Dentre as formas existentes, destacam-se a ovariosalpingohisterectomia (OSH) e a contracepção hormonal. Os fármacos anticoncepcionais de maior utilização são os análogos sintéticos da progesterona, como, Acetato de Medroxiprogesterona (AMP), o Acetato de Megestrol e a proligestona. Porém, estes provocam efeitos negativos como hiperplasia endometrial cística, levando à piometra, hiperplasia mamária, resultando em tumores mamários, aborto, diabetes mellitus, dermatopatias e distúrbios comportamentais, portanto não é recomendado o seu uso nesta espécie. Foi realizado um levantamento de dados por meio de questionários, com proprietários de gatas levadas para atendimento clínico do Hospital Veterinário Universitário Jeremias Pereira da Silva da Universidade Federal do Piauí, com o objetivo de analisar quantitativamente os casos de animais com efeitos colaterais, de acordo com a raça e a idade, correlacionado ao uso de fármacos contraceptivos. Os dados obtidos se referem aos meses de março a maio de 2015. Todos os animais descritos neste estudo que apresentaram características patológicas fizeram a utilização de fármacos contraceptivos. Nos 2 casos de piometra encontrados a faixa etária de 4 anos (50%) e 8 anos (50%) foi observada, e todos (100%) os casos ocorreram em gatas Sem Raça definida (SRD). Dos 3 casos de neoplasia mamária, animais com 9 meses correspondem a 33,3%, 1 ano (33,33%) e 2 anos (33,33%) de idade, e todos (100%) eram SRD. Dos 2 casos de abortos, a faixa etária observada foi de 2 anos (50%) e de 3 anos (50%) de idade, e as raças afetadas foram SRD (50%) e siamesa (50%). Dos 2 casos de hiperplasia mamária observados. em gatas com 6 meses (50%) e 8 meses (50%) de idade, e a única raça acometida foi a SRD (100%). Conclui-se que o uso indiscriminado de fármacos contraceptivos ainda é frequente, assim como, é elevada a quantidade de animais que apresentam efeitos negativos ao seu uso.
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- 2020
13. Management of recurrent bilateral multifocal pseudoangiomatous stromal hyperplasia (PASH)
- Author
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Kitae E Park, Xiaolu Xu, Sarah Persing, Mohammad Ali Mozaffari, Donald R. Lannin, Omar Allam, Veerle Bossuyt, and Michael Alperovich
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Pseudoangiomatous stromal hyperplasia ,Reconstructive surgery ,medicine.medical_specialty ,business.industry ,Standard treatment ,medicine.medical_treatment ,Breast Hyperplasia ,medicine.disease ,Reduction Mammoplasty ,030218 nuclear medicine & medical imaging ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,Oncology ,030220 oncology & carcinogenesis ,Breast enlargement ,Internal Medicine ,Medicine ,Breast reconstruction ,business ,Mastectomy - Abstract
Pseudoangiomatous stromal hyperplasia (PASH) is a benign hyperplastic condition of the breast that can lead to macromastia. The standard treatment for PASH is focal excision or rarely reduction mammoplasty. We present a rare case of postpartum bilateral rapid breast enlargement and axillary growth that was refractory to reduction mammoplasty. Ultimately, the patient required bilateral mastectomy and two-stage implant-based breast reconstruction. This more extensive form along with its management represents one of the few reported cases in the literature. The decision to pursue bilateral mastectomy was undertaken after exhausting more conservative options. Excellent aesthetic outcome and pain relief was obtained following definitive extirpative and reconstructive surgery.
- Published
- 2020
14. 2D-DIGE Proteomic Analysis of Changes in Estrogen/Progesterone-Induced Rat Breast Hyperplasia upon Treatment with the Mongolian Remedy RuXian-I
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Zhong-Chao Wang, Du E, De-Ligen Batu, Ya-Latu Saixi, Bin Zhang, and Li-Qun Ren
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2D-DIGE ,estrogen ,proteomics ,breast hyperplasia ,Mongolian medicine ,rat ,Organic chemistry ,QD241-441 - Abstract
RuXian-I has traditionally been used as a remedy for breast hyperplasia in the Inner Mongolia Autonomous Region of China. As a first step toward the investigation of biomarkers associated with RuXian-I treatment, a proteome-wide analysis of rat breast tissue was conducted. First, rat breast hyperplasia was induced by injection of estradiol and progesterone. After treatment with RuXian-I, there is a marked decrease in the hyperplasia, as can be shown by decreases in the nipple diameter and the pathological changes in breast. Subsequently, we used an approach that integrates size-based 2D-DIGE, MALDI-TOF/TOF-MS, and bioinformatics to analyze data from the control group, the model group and the RuXian-I treatment group. Using this approach, seventeen affected proteins were identified. Among these, 15 (including annexin A1, annexin A2, superoxide dismutase [Mn], peroxiredoxin-1, translationally-controlled tumor protein and a B-crystallin) were significantly up-regulated in the model group and down-regulated upon treatment with RuXian-I, and two (Tpil protein and myosin-4) have the opposite change trend. The expression of annexin A1 was confirmed using immunohistochemistry. The expression of superoxide dismutase (SOD) activity was confirmed biochemically. These results indicated that RuXian-I treats rat breast hyperplasia through regulation of cell cycle, immune system, metabolic, signal transduction, etc. The differential expressions of these proteins (annexin A1, superoxide dismutase [Mn], alpha B-crystallins and translationally controlled tumor protein, among others) were associated with occurrence and metastasis of breast cancer. These findings might provide not only far-reaching valuable insights into the mechanism of RuXian-I action, but also leads for prognosis and diagnosis of breast hyperplasia and breast cancer.
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- 2011
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15. Study on Breast Optical Spectrum Classification Based on Machine Learning
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Yao Qu, Xipeng Chen, Yuhan Zhang, Kai Zhang, Wenquan Huang, Zhuo Deng, and Binghua Su
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business.industry ,Computer science ,Decision tree ,Breast Hyperplasia ,food and beverages ,medicine.disease ,Machine learning ,computer.software_genre ,Bayesian inference ,Data modeling ,Breast cancer ,Clinical diagnosis ,medicine ,Breast density ,Artificial intelligence ,Medical diagnosis ,skin and connective tissue diseases ,business ,computer - Abstract
optical breast spectroscopy (OBS) can predict breast density and can be used for risk assessment of breast cancer (BC). We have used this method to study the classification and prediction of breast hyperplasia. In this paper, the collected spectral data of clinical breast hyperplasia and normal human breast were classified and predicted by using machine learning Bayesian model, decision tree and k-nearest neighbor model (KNN). The research shows that the accuracy of machine learning algorithm for classification and diagnosis of breast hyperplasia can reach 93%. The combination of machine learning algorithm and practical medical diagnosis technology is of great significance, and it can be further developed to improve the efficiency and accuracy of clinical diagnosis.
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- 2021
16. Edema periglandular e necrose epidérmica associado a tratamento de hiperplasia mamária em felino
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Aline Rocha de Menezes, Jéssica Souza Dias, Marina Andrade Rangel de Sá, Leandro Branco Rocha, Marina Luísa Ruschel, and Camila Santana Oliveira
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Pathology ,medicine.medical_specialty ,Hysterectomy ,business.industry ,medicine.medical_treatment ,Breast Hyperplasia ,Hyperplasia ,medicine.disease ,Stroma ,Edema ,medicine ,Edema formation ,medicine.symptom ,business ,Radical mastectomy ,Hormone - Abstract
A hiperplasia mamária felina, também conhecida como hiperplasia fibroepitelial, é caracterizada microscopicamente pelo rápido crescimento do estroma e epitélio ductal das glândulas mamárias em resposta a estímulo hormonal. O objetivo deste trabalho foi relatar um caso que teve um andamento inesperado pela formação de edema após a ovário-salpingo-histerectomia. Uma gata, sem raça definida, com sete meses de idade, nulípara, foi encaminhada ao Departamento de Medicina Veterinária da Universidade Federal de Sergipe, com histórico de aumento de volume de todas as cadeias mamárias há um mês, desenvolvendo os sintomas mencionados dias após a administração de um contraceptivo. Como tratamento, foi proposta a realização da ovário-salpingo-histerectomia com abordagem pelo flanco devido as mamas se apresentarem muito grandes. Após duas semanas houve redução do tecido mamário, porém grande acúmulo de líquido, corroborando para a realização de mastectomia radical no felino. Este relato chama a atenção para considerar a ocorrência deste edema nas mamas após tratamento conservador por meio de ovário-salpingo-histerectomia ou fármacos, já que pode haver uma falsa interpretação de que a mama não esteja reduzindo ou até mesmo aumentando.
- Published
- 2019
17. Melatonin inhibits cell proliferation in a rat model of breast hyperplasia by mediating the PTEN/AKT pathway
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Yibo Huang, Yingqun Niu, and Xiangjian Zhang
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0301 basic medicine ,Cancer Research ,Breast Hyperplasia ,melatonin ,Melatonin ,Random Allocation ,03 medical and health sciences ,Mammary Glands, Animal ,0302 clinical medicine ,hyperplastic disease of the breast ,Proliferating Cell Nuclear Antigen ,medicine ,Animals ,Tensin ,PTEN ,Rats, Wistar ,skin and connective tissue diseases ,Protein kinase B ,PI3K/AKT/mTOR pathway ,Cell Proliferation ,breast hyperplasia ,Hyperplasia ,biology ,Chemistry ,PTEN/AKT pathway ,PTEN Phosphohydrolase ,General Medicine ,Articles ,mammary gland hyperplasia ,Immunohistochemistry ,Rats ,Proliferating cell nuclear antigen ,Disease Models, Animal ,030104 developmental biology ,Oncology ,Apoptosis ,030220 oncology & carcinogenesis ,Cancer research ,biology.protein ,Female ,Proto-Oncogene Proteins c-akt ,Signal Transduction ,medicine.drug - Abstract
In the present study, a rat model of breast hyperplasia was established via the administration of estradiol benzoate and progesterone. Subsequent changes associated with breast hyperplasia were then investigated by measuring the diameter and height of the nipples and by staining breast tissue with hematoxylin and eosin. The proliferation and apoptosis of hyperplastic cells in the breast tissue were then determined by analyzing the expression of proliferating cell nuclear antigen (PCNA) and cleaved-caspase-3 by immunohistochemistry and TUNEL staining. We also determined the expression of proteins associated with the phosphatase and tensin homolog (PTEN)/protein kinase B (AKT) signaling pathway by western blotting. Melatonin treatment led to a significant reduction in the degree of breast hyperplasia (P
- Published
- 2021
18. HYPERPLASIA OF THE FEMALE REPRODUCTIVE ORGANS IN UKRAINE.
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Salmanov AG, Artyomenko V, Hladenko SY, Koctjuk IM, Marchenko AO, Tolstanova GO, and Korniyenko SM
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- Pregnancy, Humans, Female, Cohort Studies, Hyperplasia, Ukraine epidemiology, Risk Factors, Breast Neoplasms
- Abstract
Objective: The aim: To determine the role of infectious diseases as the cause of the Cervical, Ovarian and Breast hyperplasia in Ukraine., Patients and Methods: Materials and methods: We conducted a retrospective multicenter cohort study from January 1st, 2020 to December 31st, 2022. This study included patients aged 20-59 years with a diagnosis of hyperproliferative pathology of the women reproductive organs without atypia, who sought medical care for hyperplastic processes admitted to the 12 hospitals from 9 regions of Ukraine., Results: Results: We had examined 4,713 women; out of which 81.1% met the clinical definition of female reproductive organs hyperplasia. Of all hyperplasia cases, most frequently recorded types were breast hyperplasia (41,7%), followed by cervical hyperplasia (31,1%) and ovarian hyperplasia (27,2%). History of Cervicitis (p<0.001), Vaginal cuff infection (p<0.001), Oophoritis (p<0.001), and Mastitis (p<0.001) were identified as independent risk factors of Cervical, Ovarian and Breast hyperplasia., Conclusion: Conclusions: This study showed that surgical site infections after obstetric and gynecological operations are is the cause of Cervical, Ovarian and Breast hyperplasia. Therefore, early detection and treatment SSIs can reduce the risk of hyperplasia these organs.
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- 2023
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19. Efficacy of Psychological Interventions for Patients with Breast Hyperplasia.
- Author
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Chen, Cxian-chun, Jiang, Cheng-gang, Chen, Qing-qiu, and Gao, Dong
- Abstract
To explore the efficacy of psychological interventions (PI) in patients with breast hyperplasia (BH). In total 120 BH patients who were treated in the Third Affiliated Hospital of the Third Military Medical University were randomly divided into PI group ( n = 40; treated with oral XiaoYao Pill and psychological interventions), anti-anxiety/depression medication (AADM) group ( n = 40; treated with oral XiaoYao Pill and paroxetine), and control group ( n = 40; treated with oral XiaoYao Pill) and the treatment lasted for 1 year. Before the treatment and 4, 8, and 12 months after the initiation of treatment, the changes in the psychological indicators were measured using Toronto Alexithymia Scale (TAS), Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD), and Ways of Coping Questionnaire (WCQ), as well as the physiological indicators including estradiol, prolactin, and progesterone were determined. The overall response rates were evaluated at the end of the treatment, and the relapse rates were calculated during the 1-year follow-up. The HAMD and HAMA scores were declined in all three groups. The scores of TAS and WCQ negative coping subscales showed a declining trend after treatment for the AADM and PI groups. Compared to the control and PI groups, the HAMA and HAMD scores were significantly lower in the AADM group 4, 8, and 12 months after the initiation of treatment ( P < 0.05). The scores of TAS and WCQ negative coping subscales were significantly lower in AADM group but were significantly higher than those in PI group and lower than the control group 4, 8, and 12 months after the initiation of treatment ( P < 0.05). The HAMA and HAMD scores were significantly lower in PI group than in control group 4, 8, and 12 months after the initiation of treatment ( P < 0.05). After the initiation of treatment, the estradiol and prolactin levels decreased while the progesterone levels increased in all three groups. Compared with the control group and AADM group, the PI group had significantly higher estradiol and prolactin levels and higher progesterone levels 4, 8, and 12 months after the initiation of treatment ( P < 0.05). Compared with the control group, the AADM group had significantly lower levels of estradiol and prolactin and higher progesterone levels 4, 8, and 12 months after the initiation of treatment ( P < 0.05). The overall response rate was not significantly different for both PI group and AADM group ( P > 0.05), while the relapse rate was significantly lower in the PI group than the control and AADM groups ( P < 0.05). However, the relapse rate did not significantly differ between the control group and AADM group ( P > 0.05). PI can effectively improve the psychological status of BH patients and restore the disordered endocrine system. The efficacy lasts for long and the relapse rate is lower. Therefore, it could be an effective method for treating BH. [ABSTRACT FROM AUTHOR]
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- 2015
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20. Effect of Chinese herbal medicine compound on breast hyperplasia
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Guan, Hui-lin, Wang, Yu, Gui, Yi-fang, and Zhang, Chun-lei
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breast hyperplasia ,Adult ,Chinese herbal medicine compound ,Hyperplasia ,effect ,Breast Neoplasms ,Middle Aged ,Treatment Outcome ,Research Design ,Case-Control Studies ,Study Protocol Systematic Review ,Humans ,Female ,Breast ,Precancerous Conditions ,Research Article ,Drugs, Chinese Herbal ,Systematic Reviews as Topic - Abstract
Background: Data supporting the use of Chinese herbal medicine compound (CHMC) on breast hyperplasia (BH) based on the data from previous studies. However, the results are still contradictory. Thus, this study aims to compare the results obtained for effect on case-controlled study (CCS) of CHMC on BH. Methods: This study will include CCS assessing the effect of CHMC on BH. A literature search will be carried out in Cochrane Library, MEDLINE, EMBASE, Allied and Complementary Medicine Database, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure from inception to the present. We will not apply language limitation to any electronic database. Study quality will be evaluated using Newcastle-Ottawa Scale, and statistical analysis will be performed using RevMan 5.3 software. Results: This study will summarize the up-to-date evidence to assess the effect of CHMC on BH. Conclusion: The results of this study may exert helpful evidence to determine whether CHMC is effective on BH. OSF registration number: osf.io/3k8ch.
- Published
- 2020
21. Hyperplasia, Breast
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Pina, Luis and Baert, Albert L., editor
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- 2008
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22. Selected abbreviations and new terms in breast pathology — a guide for clinicians
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Joanna Wysocka, Beata Sas-Korczyńska, Wojciech M. Wysocki, and Janusz Ryś
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Pseudoangiomatous stromal hyperplasia ,Cancer Research ,Pathology ,medicine.medical_specialty ,business.industry ,Lobular carcinoma ,Breast Hyperplasia ,Atypical lobular hyperplasia ,Hyperplasia ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,Oncology ,Invasive carcinoma of no special type ,030220 oncology & carcinogenesis ,Medicine ,030212 general & internal medicine ,skin and connective tissue diseases ,business ,Pathological - Abstract
The aim of this article is to present briefly new pathological entities which are recently increasingly commonly used in pathology reports, as well as to discuss their clinical consequences. The new WHO classification of breast diseases includes, inter alia , invasive carcinoma of no special type: this is not a specific entity, but rather a group of malignancies without specific features. The lobular hyperplasia group includes a classical variant and a pleomorphic variant of lobular carcinoma in situ, as well as atypical lobular hyperplasia. The ductal hyperplasia group, according to the current revision of the WHO classification of breast diseases, encompasses: typical (i.e. non-atypical) ductal hyperplasia, columnar cell change, columnar cell hyperplasia, atypical ductal hyperplasia. The mesenchymal breast hyperplasia group includes pseudoangiomatous stromal hyperplasia. We briefly discuss the above mentioned entities together with their respective clinical and therapeutic consequences.
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- 2017
23. The Internal Mammary Artery Perforator (IMAP) Breast-Flap Harvested From an Asymmetric Hyperplastic Breast for Correction of a Mild Funnel Chest Deformity.
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Schwabegger, Anton, Piza-Katzer, Hildegunde, Pauzenberger, Reinhard, and Del Frari, Barbara
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Pectus excavatum deformity is the most frequent congenital anomaly of the thoracic wall. If the invasive surgical procedures of thoracoplasty are not indicated or the patient refuses them, alternative treatment options should be considered. In such cases, local or distant transposition of autologous tissue could be appropriate. This report presents a selected case of funnel chest deformity and concomitant unilateral breast hyperplasia. Both deformities were corrected simultaneously using a pedicled internal mammary artery perforator (IMAP) flap dissected from the hyperplastic breast. This is a safe, reliable, low-morbidity, one-stage option for adult women that uses an easy-to-harvest flap for simultaneous correction of mild funnel chest deformity and concomitant breast hyperplasia with a single resulting scar. [ABSTRACT FROM AUTHOR]
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- 2011
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24. New trends in breast reconstructive surgery: "Florentine Lily" reductive mastoplasty.
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ROGLIANI, M., GENTILE, P., TRIMARCO, A., LABARDI, L., BRINCI, L., PALLA, L., and CERVELLI, V.
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Background: To describe a mammoplasty technique that we called "Florentine Lily" because of the shape of the pre-operative drawings similarity with the symbol lily Florentine. Methods: In a group of 190 women who underwent reductive mammoplasty, 23 women affected by severe enlarged breasts were selected. Main selection requirements were: 18-30 cm rising of the Areola-Nipple Complex (NAC). Results: to obtain a functional and cosmetic result; preservation of mammary gland function; vitality of the areola-nipple complex and its sensitivity. We describe the case of 35 years old woman affected by severe enlargement of the breast and no pathologies. Conclusion: We didn't observe necrosis of the skin flaps and NAC in any case. In one case (rising of Nipple-Areola Complex >25 cm) NAC showed NAC 2 days post-surgery, which spontaneously resolved. Minor complications (edema and ematoma) developed in 20 cases. No infections were observed. [ABSTRACT FROM AUTHOR]
- Published
- 2010
25. Hiperplasia mamária felina: por que é tão comum no Brasil?
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Camilla Freitas Oliveira, Renata Santiago Alberto Carlos, Jamille Bispo de Carvalho Teixeira, and Paula Elisa Brandão Guedes
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education.field_of_study ,medicine.medical_specialty ,Pregnancy ,business.industry ,Population ,Breast Hyperplasia ,Physiology ,Surgical sterilization ,medicine.disease ,Breast cancer ,Epidemiology ,medicine ,General Earth and Planetary Sciences ,education ,business ,General Environmental Science ,Hormone - Abstract
A Hiperplasia mamária felina (HMF) é uma alteração não neoplásica, caracteriza pela proliferação celular do estroma do ducto das glândulas mamárias, comumente diagnosticada no Brasil. Tal alteração muitas vezes é causada pelo uso inadequado de progestágenos exógenos em gatos, que podem ser armazenados no organismo do animal, e sensibilizam as glândulas à proliferação exacerbada por estímulo hormonal. Um dos fatores associados aos casos recorrentes da HMF é a venda desses medicamentos em lojas que prestam serviço de venda de produtos veterinários, aplicados sem restrições e sem conhecimento da fisiologia felina, na tentativa de controle gestacional. A conscientização de tutores sobre os malefícios da aplicação sem critério de progestágenos e a estimulação dos mesmos para que optem por esterilização cirúrgica dos seus animais deve ser feita pelos médicos veterinários, a fim de que se evitem maiores complicações como neoplasia mamária, garantindo, portanto, maior bem estar da população felina. O objetivo dessa revisão é abordar aspectos epidemiológicos, fisiológicos e clínicos, e promover alusão ao uso indiscriminado de anticoncepcionais nessa espécie.
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- 2021
26. Artesunate attenuates proliferation of epithelial cells by downregulating the NF-κB and AKT signaling pathways in benign mammary gland hyperplasia rats
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Yiliang Li, Wei Li, Zhen Zhai, and Lina Zhao
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biology ,Cell growth ,Chemistry ,Breast Hyperplasia ,General Medicine ,Hyperplasia ,medicine.disease ,Proliferating cell nuclear antigen ,In vivo ,Cancer research ,biology.protein ,medicine ,Immunohistochemistry ,Phosphorylation ,Original Article ,Protein kinase B - Abstract
BACKGROUND: The aim of this study was to investigate the effects of artesunate (ART) on breast epithelial cell proliferation in vitro and in vivo. METHODS: Immortalized human non-cancer mammary epithelial (MCF-10A) cells were used to determine the effect of ART on estrogen-induced mammary hyperplasia cells. We investigated the effect of ART on the synthesis of cyclooxygenase-2 (COX-2) and proliferating cell nuclear antigen (PCNA) in MCF-10A by treating MCF-10A 36 h with different concentrations of ART (0, 100, 200, 400 µm, n=12/group). We then investigated the effect of ART on estrogen induced COX-2, PCNA, nuclear factor-kappa B (NF-κB), and pNF-κB synthesis by treating MCF-10A with both estrogen and ART (0, 50, 100, 200 µm, n=12/group). A mammary hyperplasia model (MGH) was established in rats. All rats (n=12) were divided into 4 groups [group A: negative control (NC) + Art −; group B: NC + Art +; group C: MGH + Art −; group D: MGH + Art +] by the random number table method and the effects of ART on estradiol-induced mammary hyperplasia, fibrosis, and phosphorylation of AKT and NF-κB were studied by histopathological staining, Masson trichrome staining, immunohistochemistry (IHC), and western blotting. RESULTS: The proliferation and inflammation of mammary epithelial cells were blocked by ART (P
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- 2021
27. Meme küçültme cerrahisinin solunum fonksiyon testleri üzerine etkisi
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Goksel Altinisik, Erhan Ugurlu, Ilknur Can, Adem Topkara, Ramazan Hakan Özcan, and Adem Özkan
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Mammaplasty ,medicine.medical_treatment ,neck pain ,spirometry ,Mammoplasty ,postoperative period ,Critical Care and Intensive Care Medicine ,Reduction Mammoplasty ,Pulmonary function testing ,Breast Diseases ,DLCO ,middle aged ,respiratory function tests ,surgery ,lung ,breast reconstruction ,Medicine ,Lung ,pathophysiology ,thorax radiography ,clinical article ,medicine.diagnostic_test ,Respiratory function tests ,backache ,Respiratory Function Tests ,female ,thorax deformity ,Female ,Breast reduction ,plastic surgeon ,Adult ,Pulmonary and Respiratory Medicine ,Spirometry ,medicine.medical_specialty ,lung function test ,shoulder pain ,Breast surgery ,residual volume ,carbon monoxide ,Article ,FEV1/FVC ratio ,forced vital capacity ,forced expiratory flow ,follow up ,Humans ,human ,procedures ,breast reduction ,preoperative period ,breast hyperplasia ,business.industry ,thorax pain ,breast disease ,asthma ,body mass ,Surgery ,carbon monoxide diffusion test ,total lung capacity ,business - Abstract
Introduction: Bilateral breast reduction surgery is the surgical treatment of bilateral breast hypertrophy. This is one of the most common breast surgery requested by women, and performed by plastic surgeons. The reasons that patients want this surgery are to re-size sagging breasts aesthetically, and to get rid of somatic symptoms such as shoulder, chest, back, and neck pain. We believe that the objective positive effects of breast reduction surgery exist beside aesthetic. In our study, our aim is to elicit positive effects of surgery on lungs, if there are, by making pulmonary function test and carbon monoxide diffusion test before surgery and after 6 months of surgery. Materials and Methods: Thirty patients agreed to participate in the study. Study is completed with 19 patients. Pulmonary function test and carbon monoxide diffusion test were made to all patients in preoperative and 6 months of postoperative period. Lung roentgenogram of all patients was performed and height, weight, body mass index were measured. Saturation level was measured. Results: There was a meaningful increase in FEV1 and FVC values in the postoperative period in comparison with pulmonary function test performed in preoperative period. DLCO in postoperative period decreased meaningfully as compared to the preoperative period. Conclusion: Breast reduction surgery seems to have positive effects on pulmonary function test values and relaxes patients clinically. Patients with big breasts should be evaluated from this perspective if they apply chest diseases clinic with shortness of breath. © 2017, Ankara University. All rights reserved.
- Published
- 2017
28. Diagnosis of Breast Hyperplasia and Evaluation of RuXian-I Based on Metabolomics Deep Belief Networks
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Fengfeng Zhou, Xiaoyue Feng, Zhili Pei, Mingyang Jiang, Chengxi Wei, Yanchun Liang, and Xiye Wang
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0301 basic medicine ,Oncology ,medicine.medical_specialty ,Breast Hyperplasia ,Breast Neoplasms ,Overfitting ,Article ,Catalysis ,lcsh:Chemistry ,Inorganic Chemistry ,03 medical and health sciences ,Deep belief network ,0302 clinical medicine ,Metabolomics ,Breast cancer ,breast cancer ,Internal medicine ,Evaluation methods ,medicine ,Humans ,Computer Simulation ,Physical and Theoretical Chemistry ,Mammary Glands, Human ,lcsh:QH301-705.5 ,Molecular Biology ,Spectroscopy ,Dropout (neural networks) ,Hyperplasia ,business.industry ,Organic Chemistry ,Cancer type ,deep belief networks ,General Medicine ,Models, Theoretical ,metabolomic data ,medicine.disease ,Computer Science Applications ,030104 developmental biology ,lcsh:Biology (General) ,lcsh:QD1-999 ,030220 oncology & carcinogenesis ,Female ,business ,Mongolian medicine - Abstract
Breast cancer is estimated to be the leading cancer type among new cases in American women. Core biopsy data have shown a close association between breast hyperplasia and breast cancer. The early diagnosis and treatment of breast hyperplasia are extremely important to prevent breast cancer. The Mongolian medicine RuXian-I is a traditional drug that has achieved a high level of efficacy and a low incidence of side effects in its clinical use. However, for detecting the efficacy of RuXian-I, a rapid and accurate evaluation method based on metabolomic data is still lacking. Therefore, we proposed a framework, named the metabolomics deep belief network (MDBN), to analyze breast hyperplasia metabolomic data. We obtained 168 samples of metabolomic data from an animal model experiment of RuXian-I, which were averaged from control groups, treatment groups, and model groups. In the process of training, unlabelled data were used to pretrain the Deep Belief Networks models, and then labelled data were used to complete fine-tuning based on a limited-memory Broyden Fletcher Goldfarb Shanno (L-BFGS) algorithm. To prevent overfitting, a dropout method was added to the pretraining and fine-tuning procedures. The experimental results showed that the proposed model is superior to other classical classification methods that are based on positive and negative spectra data. Further, the proposed model can be used as an extension of the classification method for metabolomic data. For the high accuracy of classification of the three groups, the model indicates obvious differences and boundaries between the three groups. It can be inferred that the animal model of RuXian-I is well established, which can lay a foundation for subsequent related experiments. This also shows that metabolomic data can be used as a means to verify the effectiveness of RuXian-I in the treatment of breast hyperplasia.
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- 2019
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29. Effect of auricular point pressing therapy on hyperplasia of mammary glands
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Xiangli Wang, Liuqiao Zhang, and Mengjie Ma
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medicine.medical_specialty ,Massage ,business.industry ,Breast Hyperplasia ,MEDLINE ,General Medicine ,Hyperplasia ,Cochrane Library ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Meta-analysis ,Internal medicine ,medicine ,Endocrine system ,030212 general & internal medicine ,Adverse effect ,business - Abstract
Background In recent years, with the accelerated pace of life, diet, environmental problems occur frequently. External factors are easily to cause endocrine disorders and hormone sensitivity of breast tissue, which can lead to mammary hyperplasia. The incidence rate of hyperplasia of mammary glands is increasing year by year, and the age of onset is also getting lower and lower. If not treated in time, there is a crisis of breast cancer.Clinical studies have found that auricular point pressing therapy is widely used in clinical treatment of mammary hyperplasia recently, but the efficacy of massage in the treatment of mammary hyperplasia has not been systematically reviewed. The purpose of this study is to explore the efficacy, safety and effectiveness of auricular point pressing therapy in the treatment of hyperplasia of mammary glands. Methods We will search PubMed, Web of Science, Cochrane Library, EMBASE, Wan fang Database, Chinese Scientific Journal Database, CNKI, VIP, and Chinese Biomedical Literature Database. The retrieval date was January 10, 2021. RevMan 5.3 software was used to evaluate the quality and risk of included studies. The efficacy, recurrence rate, and symptom score of breast hyperplasia were analyzed, and the results were observed and measured. Results This study will be from the clinical efficiency, improvement rate, pain symptoms disappear rate, tumor size improvement rate, and other aspects of the existing evidence for a high quality synthesis, as well as auricular point pressing therapy adverse events. Conclusion the conclusion of this review will provide the basis for judging whether auricular point pressing therapy is safe and effective in the treatment of hyperplasia of mammary glands. Ethics and dissemination This systematic will evaluate the effectiveness and safety of auricular point pressing therapy in the treatment of hyperplasia of mammary glands. As all data used in this systematic review and meta-analysis have been published, ethical approval is not required for this review. Protocol registration number INPLASY202110028.
- Published
- 2021
30. Massage treatment of hyperplasia of mammary glands
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Xiaolin Zhang, Guochao Liu, Dehui Ma, Qi Zhang, Tianjiao Gao, and Mingjun Liu
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medicine.medical_specialty ,Massage ,business.industry ,Breast Hyperplasia ,MEDLINE ,General Medicine ,Hyperplasia ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Internal medicine ,Meta-analysis ,medicine ,Endocrine system ,030212 general & internal medicine ,Age of onset ,business ,Adverse effect - Abstract
Background With the accelerated pace of life, the problems of residence, diet, and environment have occurred frequently in recent years. External factors are easily to cause endocrine disorders and hormone sensitivity of breast tissue, which can lead to mammary hyperplasia. The incidence rate of hyperplasia of mammary glands is increasing year by year, and the age of onset is also getting lower and lower. If not treated in time, there is a crisis of breast cancer.Clinical studies have found that massage is widely used in clinical treatment of mammary hyperplasia recently, but the efficacy of massage in the treatment of mammary hyperplasia has not been systematically reviewed. The purpose of this study is to explore the efficacy, safety and effectiveness of massage in the treatment of hyperplasia of mammary glands. Methods We will search PubMed, Cochrane Central Register of controlled trials (central), ScienceNet, EMBASE, CBM, CNKI, VIP and Wanfang databases. The retrieval date was October 20, 2020. RevMan 5.3 software was used to evaluate the quality and risk of included studies. The efficacy, recurrence rate, and symptom score of breast hyperplasia were analyzed, and the results were observed and measured. Results This study will be from the clinical efficiency, improvement rate, pain symptoms disappear rate, tumor size improvement rate and other aspects of the existing evidence for a high quality synthesis, as well as massage adverse events. Conclusion the conclusion of this review will provide the basis for judging whether massage is safe and effective in the treatment of hyperplasia of mammary glands. Ethics and dissemination This systematic will evaluate the effectiveness and safety of massage in the treatment of hyperplasia of mammary glands. As all data used in this systematic review and meta-analysis have been published, ethical approval is not required for this review. Protocol registration number INPLASY2020100066.
- Published
- 2020
31. Ki-67 expression in luminal type breast cancer and its association with the clinicopathology of the cancer
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Chengzheng Wang, Long Yuan, Miaomiao Sun, Peng Yuan, Chengjuan Zhang, and Benling Xu
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0301 basic medicine ,Oncology ,Cancer Research ,medicine.medical_specialty ,Pathology ,proliferation ,Breast Hyperplasia ,CA 15-3 ,MCF-7 cell line ,migration ,03 medical and health sciences ,breast cancer ,0302 clinical medicine ,Breast cancer ,Internal medicine ,medicine ,skin and connective tissue diseases ,biology ,Oncogene ,business.industry ,Cancer ,Articles ,medicine.disease ,Molecular medicine ,030104 developmental biology ,030220 oncology & carcinogenesis ,Ki-67 ,Cancer cell ,biology.protein ,business - Abstract
The aim of the present study was to examine Ki-67 expression in tissue of luminal type breast cancer and to investigate the association between the Ki-67 expression level and clinicopathology of breast cancer. A total of 62 patients with breast cancer were included in the study group, whereas 30 patients undergoing a health check-up who were diagnosed with breast hyperplasia were included in the control group. Levels of Ki-67 expression in patients of the two groups were assessed using fluorescent quantitative polymerase chain reaction. The association between Ki-67 and the clinicopathology of the cancer was investigated by analyzing cancer cell proliferation and migration by reducing Ki-67 expression in the human MCF-7 cancer cell line. Compared with the controls, Ki-67 expression was significantly increased in the serum and cancer tissue of breast cancer patients (P
- Published
- 2016
32. Systematic Evaluation on Clinical Efficacy of External Application of Traditional Chinese Medicine in Treatment of Breast Hyperplasia
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Yan-hong Lyu, Jing-fang XIANG, Kang ZHANG, and Qin LU
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Random ,system evaluation ,Breast hyperplasia ,lcsh:R ,External application of traditional Chinese medicine ,lcsh:Medicine ,Meta analysis - Abstract
Objective: To evaluate the clinical efficacy of external application of traditional Chinese medicine (TCM) in the treatment of breast hyperplasia. Methods: Randomized controlled clinical trial literatures on external application of TCM in the treatment of breast hyperplasia published in PubMed, Excerpta Medica Database (EMBASE), Cochrane Central Register of Controlled Trials (CENTRAL) , China National Knowledge Infrastructure Database (CNKI) and Chinese Biomedical Abstract Database (CBM) from January 2000 to August 2015 were retrieved, and screened by researchers to data extraction. RevMan 5.3 was applied for Meta analysis. Results: A total of 15 clinical trials with 2 107 patients with breast hyperplasia were included, in which 1 151 were divided into treatment group treated with external application of TCM while 956 into control group. Meta analysis indicated that the clinical response rate and clinical symptom score improvement (lump size) as well as serum levels of estradiol (E2), progesterone (P) and prolactin (PRL) in treatment group were superior to the control group and the differences were statistically significant (PP>0.05). Conclusion: External application of TCM, to some extent, can improve the clinical efficacy in the treatment of breast hyperplasia, and it is necessary to carry out higher-quality, multicenter, large-scale, prospective and double-blind clinical experiments for further validation.
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- 2015
33. Early experience with Lejour vertical scar reduction mammaplasty technique.
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Berg, A., Palmer, B., and Stark, B.
- Abstract
The study contains 163 patients who underwent a reduction mammaplasty at the Karolinska Hospital during 1991-1992. Seventy patients were operated on using the Lejour short scar technique (superovertical pedicle) and 93 using the Strömbeck method (medial pedicle). The aim of this study was to compare the results of these two different methods with regard to scar formation, position and sensation in the nipple areola complex, postoperative complications, healing conditions, shape and volume symmetry of the breasts and patient satisfaction. An objective method [20] was used for assessment of postoperative breast asymmetry. Advantages and disadvantages of both methods are presented. The incidence of early complications was low in both groups, compared with the data presented in the literature, but Strömbeck's method was found to be superior in some respects because of fewer early postoperative complications, shorter healing period and better breast symmetry postoperatively. [ABSTRACT FROM AUTHOR]
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- 1995
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34. Changes in the activity of adenosine deaminase and the content of polyamines in the blood of cats with breast cancer
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Natalya Akinina, Elena Bakurova, Alexey Ermakov, Natalya Dobaeva, and Maya Vakulenko
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lcsh:GE1-350 ,0303 health sciences ,CATS ,biology ,040301 veterinary sciences ,business.industry ,Mammary gland ,Breast Hyperplasia ,Physiology ,Cancer ,04 agricultural and veterinary sciences ,medicine.disease ,0403 veterinary science ,03 medical and health sciences ,medicine.anatomical_structure ,Adenosine deaminase ,Breast cancer ,Blood plasma ,biology.protein ,Carcinoma ,Medicine ,business ,lcsh:Environmental sciences ,030304 developmental biology - Abstract
In this work, the clinical significance of changes in the activity of adenosine deaminase (ADA) and the content of polyamines in the blood plasma of cats with breast cancer was studied. There were examined 30 cats aged 1 to 20 years, operated on in veterinary clinics due to spontaneous neoplasms. Histological studies of surgical material were performed to establish nosological forms of the tumor. The results of the measurements showed that there were no significant differences between ADA activity in the blood plasma of cats diagnosed with invasive non-specific carcinoma and ADA activity in the blood of healthy animals. In the plasma of animals diagnosed with fibroadenomatous breast hyperplasia, ADA activity was reduced by 35% compared with the control group. The content of putrescine in the red blood cells of cats with benign neoplasms of the mammary gland (fibroepithelial hyperplasia) was statistically significantly increased 5 times compared with the control group. In malignant neoplasms of the mammary gland (invasive non-specific carcinoma, tubular cancer and fibrosarcoma), the content of putrescine and spermine in the blood significantly exceeded the control values by 60 and 10 times, respectively, compared with the control group. Thus, the data obtained indicate the possibility of using polyamines in order to improve the accuracy of diagnosis and treatment of cats with breast cancer. The determination of ADA activity in the blood plasma of cats with breast tumors in the early stages of cancer is not an informationally significant indicator as a tumor biomarker.
- Published
- 2019
35. MicroRNA array analysis of the regulation of microRNAs in rats exhibiting hyperplasia of mammary glands
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Haitao Liu, Qingxin Xu, Jingru Xie, Liyan Gu, and Lide Zhang
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miRNA array ,Oncogene ,General Neuroscience ,Breast Hyperplasia ,hyperplasia of mammary glands ,Articles ,General Medicine ,Hyperplasia ,Biology ,medicine.disease ,Molecular medicine ,molecular biological mechanism ,General Biochemistry, Genetics and Molecular Biology ,RNA interference ,microRNA ,Gene expression ,Cancer research ,medicine ,Gene silencing ,profiling ,General Pharmacology, Toxicology and Pharmaceutics - Abstract
Hyperplasia of mammary glands (HMG) is also termed mammary dysplasia. In China, the number of patients suffering from breast hyperplasia is increasing annually. MicroRNAs (miRNAs; length, 19-24 nucleotides), a group of small endogenous non-coding RNAs, post-transcriptionally regulate gene expression via RNA interference and gene silencing pathways. The cause of disease of HMG because remains unclear. Thus, the aim of the present study was to establish comprehensive profile of drug treatments following at different time intervals on rat models of differentially expressed miRNAs, using miRNA microarray data. After scanning the chip, 13 up-regulated and 20 down-regulated miRNAs were identified. MiR-31 and miR-30 exhibited different expression levels between rats exhibiting mammary gland hyperplasia treated with or without Jiedu Capsule water solution once a day for 4 weeks, and the two demonstrated a strong association with HMG and breast cancer. Therefore, the functions of these miRNAs may provide the basis for further investigation of HMG.
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- 2018
36. [Mechanism of Xiaoyao San in treatment of depression,breast hyperplasia,and functional dyspepsia based on network pharmacology].
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Wei FX, Liu HL, Fan YH, Li XQ, Zhao SJ, Qin XM, and Liu XJ
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- Depression drug therapy, Humans, Hyperplasia drug therapy, Medicine, Chinese Traditional, Molecular Docking Simulation, Drugs, Chinese Herbal pharmacology, Dyspepsia drug therapy
- Abstract
This study aimed to explore the mechanism of Xiaoyao San(XYS) in the treatment of three diseases of liver depression and spleen deficiency, ie, depression, breast hyperplasia, and functional dyspepsia, and to provide a theoretical basis for the interpretation of the scientific connotation of "treating different diseases with the same method" of traditional Chinese medicines. Traditional Chinese medicine systems pharmacology database and analysis platform(TCMSP) was used to screen the active components of XYS which underwent principal component analysis(PCA) with the available drugs for these three diseases to determine the corresponding biological activities. The targets of XYS on depression, breast hyperplasia, and functional dyspepsia were obtained from GeneCards, TTD, CTD, and DrugBank databases. Cytoscape was used to plot the "individual herbal medicine-active components-potential targets" network. The resulting key targets were subjected to Kyoto encyclopedia of genes and genomes(KEGG) pathway analysis and gene ontology(GO) enrichment analysis. A total of 121 active components of XYS and 38 common targets in the treatment of depression, breast hyperplasia, and functional dyspepsia were collected. The key biological pathways were identified, including advanced glycation and products(AGEs)-receptor for advanced glycation and products(RAGE) signaling pathway in diabetic complications, HIF-1 signaling pathway, and cancer-related pathways. The key targets of XYS in the treatment of depression, breast hyperplasia, and functional dyspepsia included IL6, IL4, and TNF, and the key components were kaempferol, quercetin, aloe-emodin, etc. As revealed by the molecular docking, a strong affinity was observed between the key components and the key targets, which confirmed the results. The therapeutic efficacy of XYS in the treatment of diseases of liver depression and spleen deficiency was presumedly achieved by reducing the inflammatory reactions. The current findings are expected to provide novel research ideas and approaches to classify the scientific connotation of "treating different diseases with the same method" of Chinese medicines, as well as a theoretical basis for understanding the mechanism of XYS and exploring its clinical applications.
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- 2021
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37. Abstract P4-08-03: Demonstration of the evolutionary dynamics of the progression from breast hyperplasia to cancer using the duct epithelial agent based model (DEABM)
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Swati Kulkarni, Joaquin Chapa, and Gary An
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Cancer Research ,Telomerase ,Pathology ,medicine.medical_specialty ,education.field_of_study ,business.industry ,Population ,Myoepithelial cell ,Breast Hyperplasia ,Hyperplasia ,medicine.disease ,medicine.disease_cause ,Breast cancer ,Oncology ,medicine ,Atypia ,skin and connective tissue diseases ,Carcinogenesis ,education ,business - Abstract
Introduction: Abnormal proliferation in the breast is clinically seen ranging from hyperplasia to atypia to in situ carcinomas (DCIS) to invasive cancers. Whether these states comprise points along an evolutionary continuum is a subject of debate, but has significant implications for prevention, prognosis, and treatment. Due to the length of time involved, tumor evolution is difficult to study in vivo and in vitro models. We hypothesize a continuum from hyperplasia to cancer can be demonstrated by examining patterns of accumulated mutations in tumors. We employ a previously developed computational model of ductal epithelial dynamics, the DEABM (1), to simulate and track accumulated mutations during the progression from a normal epithelial population through hyperplastic states to the development of invasive tumors Methods: Simulation experiments were performed using an expanded DEABM, which incorporates the functions of luminal and myoepithelial cells, their progenitors and fibroblasts. DNA damage can potentially disrupt 12 functional pathways regulated by oncogenes and tumor suppressors implicated in breast cancer (BRCA1, P53, E-cadherin, RUNX3, Myc, ER, TGF-b, MMP-3, EGFR, HER-2 and Telomerase). The expanded DEABM allows for sequential tracking of genetic lesions in each cell. 3,000 simulations in both wild-type (WT) and BRCA1-mutated states were run over 40 years of simulated menses. Cell populations were characterized as normal, hyperplastic or malignant based on quantitative cell expansion from baseline, as well as by mutational profiles, sequential order of mutations and ER status. Results: Tumor profiles approximated epidemiologic rates of cancer incidence and ER/HER2 status. 2.6 % of WT developed malignancy vs. 45.9% of BRCA1. WT tumors were 54% ER+/HER2-, 17% ER+/HER2+, 6% ER-/HER2+ and 22% ER-/HER2-. BRCA1 tumors were 29% ER+/HER2-, 7% ER+/HER2+, 13% ER-/HER2+ and 50% ER-/HER2-. Hyperplastic populations carried more mutations than non-hyperplastic populations (p>.01) and were more likely to carry mutations in telomerase, E-cadherin and genes related to ER expression (TGFB, RUNX3, p Conclusion: The DEABM generates diverse tumors that express tumor markers consistent with epidemiologic data. The DEABM also generates non-invasive, hyperplastic populations, analogous to atypia and/or DCIS, via mutations to genes known to be present in hyperplastic lesions and early mutations in breast cancers. The results demonstrate that agent-based models are well-suited to studying tumor evolution through stages of carcinogenesis and have the potential to be used to develop prevention and treatment strategies. Ref: Chapa J, et al. "Examining the Pathogenesis of Breast Cancer Using a Novel Agent-Based Model of Mammary Ductal Epithelium Dynamics." PloS one 8.5 (2013). Citation Format: Joaquin Chapa, Gary An, Swati A Kulkarni. Demonstration of the evolutionary dynamics of the progression from breast hyperplasia to cancer using the duct epithelial agent based model (DEABM) [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P4-08-03.
- Published
- 2015
38. Efficacy of Psychological Interventions for Patients with Breast Hyperplasia
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Cxian-chun Chen, Dong Gao, Qing-qiu Chen, and Cheng-gang Jiang
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Adult ,medicine.medical_specialty ,Coping (psychology) ,Breast hyperplasia ,Biophysics ,Psychological intervention ,Aftercare ,Biochemistry ,Toronto Alexithymia Scale ,Recurrence ,Internal medicine ,Hamd ,medicine ,Humans ,Endocrine system ,Breast ,Psychiatric Status Rating Scales ,Original Paper ,Hyperplasia ,medicine.diagnostic_test ,business.industry ,Cell Biology ,General Medicine ,Efficacy evaluation ,Paroxetine ,Prolactin ,Treatment Outcome ,Pill ,Female ,business ,medicine.drug - Abstract
To explore the efficacy of psychological interventions (PI) in patients with breast hyperplasia (BH). In total 120 BH patients who were treated in the Third Affiliated Hospital of the Third Military Medical University were randomly divided into PI group (n = 40; treated with oral XiaoYao Pill and psychological interventions), anti-anxiety/depression medication (AADM) group (n = 40; treated with oral XiaoYao Pill and paroxetine), and control group (n = 40; treated with oral XiaoYao Pill) and the treatment lasted for 1 year. Before the treatment and 4, 8, and 12 months after the initiation of treatment, the changes in the psychological indicators were measured using Toronto Alexithymia Scale (TAS), Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD), and Ways of Coping Questionnaire (WCQ), as well as the physiological indicators including estradiol, prolactin, and progesterone were determined. The overall response rates were evaluated at the end of the treatment, and the relapse rates were calculated during the 1-year follow-up. The HAMD and HAMA scores were declined in all three groups. The scores of TAS and WCQ negative coping subscales showed a declining trend after treatment for the AADM and PI groups. Compared to the control and PI groups, the HAMA and HAMD scores were significantly lower in the AADM group 4, 8, and 12 months after the initiation of treatment (P P P P P P > 0.05), while the relapse rate was significantly lower in the PI group than the control and AADM groups (P P > 0.05). PI can effectively improve the psychological status of BH patients and restore the disordered endocrine system. The efficacy lasts for long and the relapse rate is lower. Therefore, it could be an effective method for treating BH.
- Published
- 2015
39. Melatonin inhibits cell proliferation in a rat model of breast hyperplasia by mediating the PTEN/AKT pathway.
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Zhang X, Niu Y, and Huang Y
- Subjects
- Animals, Cell Proliferation drug effects, Disease Models, Animal, Female, Hyperplasia drug therapy, Hyperplasia enzymology, Hyperplasia pathology, Immunohistochemistry, Mammary Glands, Animal enzymology, Mammary Glands, Animal pathology, Proliferating Cell Nuclear Antigen metabolism, Random Allocation, Rats, Rats, Wistar, Signal Transduction drug effects, Mammary Glands, Animal drug effects, Melatonin pharmacology, PTEN Phosphohydrolase metabolism, Proto-Oncogene Proteins c-akt metabolism
- Abstract
In the present study, a rat model of breast hyperplasia was established via the administration of estradiol benzoate and progesterone. Subsequent changes associated with breast hyperplasia were then investigated by measuring the diameter and height of the nipples and by staining breast tissue with hematoxylin and eosin. The proliferation and apoptosis of hyperplastic cells in the breast tissue were then determined by analyzing the expression of proliferating cell nuclear antigen (PCNA) and cleaved‑caspase‑3 by immunohistochemistry and TUNEL staining. We also determined the expression of proteins associated with the phosphatase and tensin homolog (PTEN)/protein kinase B (AKT) signaling pathway by western blotting. Melatonin treatment led to a significant reduction in the degree of breast hyperplasia (P<0.05), a significant reduction in PCNA, a significant increase in the level of apoptosis (P<0.05), a significant increase in PTEN (P<0.05), and a significant reduction in AKT/p‑AKT (P<0.05). Furthermore, melatonin significantly decreased the aggravation of breast hyperplasia induced by application of a PTEN inhibitor. Melatonin reduced the degree of breast hyperplasia, reduced the proliferation of hyperplastic breast tissue cells, and promoted cell apoptosis in hyperplastic tissue. These effects were achieved by the specific regulation of proteins in the PTEN/PI3K/AKT axis.
- Published
- 2021
- Full Text
- View/download PDF
40. Pseudo Angiomatous Stromal Hyperplasia of the Breast: A Case of A 19-Year-Old Asian Girl
- Author
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Yuzhu Zhang, Yijia Bao, Weihong Zhang, and Yongxi Yuan
- Subjects
medicine.medical_specialty ,business.industry ,Menstrual disorder ,Incidence (epidemiology) ,medicine.medical_treatment ,Breast Hyperplasia ,Hyperplasia ,medicine.disease ,Dermatology ,medicine ,Endocrine system ,Breast reduction ,skin and connective tissue diseases ,business ,Quadrantectomy ,Tamoxifen ,medicine.drug - Abstract
Pseudo Angiomatous Stromal Hyperplasia (PASH), a benign disease with extremely low incidence, is manifested as giant breasts, frequent relapse after surgery, or endocrine disorder. Cases with unilateral breast and undetailed endocrine condition have been reported in African and American. In this case, a 19-year-old Asian girl suffered from bilateral breast PASH after the human placenta and progesterone treatment for 3-month delayed menstruation. Her breasts enlarged remarkably 1 month after the treatment, with extensive inflammatory swell in bilateral mammary glands and subcutaneous edema in retro mammary space. The patient received the bilateral quadrantectomy plus breast reduction and suspension surgery to terminate the progressive hyperplasia of breast. During the whole treatment period, the patient was given tamoxifen treatment for 4 months, and endocrine levels were intensively recorded. The follow-up after 4 months showed recovered breast with normal shape and size, and there was no distending pain, a tendency toward breast hyperplasia, or menstrual disorder. Level of Evidence: Level IV, case study. Keywords: Pseudo angiomatous stromal hyperplasia; 19-year-old Asian girl; Tamoxifen
- Published
- 2017
41. Screening for Prostate Specific Antigen in Various Types of Breast Tumor
- Author
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Ahmed M. Osman, Abdel-Rahman B. Abdel-Ghaffar, Ahmed El-Bayoumy, and Marwa Ali Fawzy
- Subjects
PCA3 ,Oncology ,Immunoradiometric assay ,medicine.medical_specialty ,business.industry ,Breast Hyperplasia ,CA 15-3 ,medicine.disease ,Menopause ,Prostate-specific antigen ,Breast cancer ,Internal medicine ,medicine ,Immunohistochemistry ,skin and connective tissue diseases ,business - Abstract
The objective of the present study was to investigate a comparative estimation screening method of prostate specific antigen levels in serum samples with immunohistochemistry results for analysis expression of prostate specific antigen in female breast tissues at benign breast hyperplasia and breast cancer. This study was applied on 65 women suffering from breast cancer, 31 of them have benign breast hyperplasia and 34 have malignant breast cancer. Each group was divided into 2 subgroups, pre and postmenopause, both subgroups were compared with 15 normal cases to assess serum and tissue PSA in benign and malignant patients in pre and post menopause state by immunoradiometric assay in blood and immunohistochemistry in tissue. No significant difference in serum Total PSA concentration between any of the studied cases. However, there were different variations in the distribution of PSA in the breast tumor tissue, with complete absence of PSA in the tissue samples of the malignant in postmenopausal patients. In conclusion, PSA presence in benign breast hyperplasia in either serum or tissue may show clinical value regarding the diagnosis and prognosis of the disease.
- Published
- 2017
42. The effect of gigantomasty on vertebral degeneration: A computed tomography study
- Author
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Fatma Ezgi Can, Mehmet Erdi Korkmaz, Omer Fatih Nas, Kadir Hacikurt, Bekir Şanal, Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı., Nas, Ömer Fatih, Hacıkurt, Kadir, and AAG-8561-2021
- Subjects
Male ,Lordosis ,Column ,Breast hyperplasia ,Chronic pain ,Degeneration (medical) ,030230 surgery ,Gigantomasty ,Back-pain ,Procedures ,Reduction Mammoplasty ,Intervertebral disk degeneration ,0302 clinical medicine ,Breast reduction surgery ,Back pain ,Orthopedics and Sports Medicine ,Disease ,Breast ,Computed tomography ,Tomography ,Priority journal ,Rehabilitation ,Low back pain ,Retrospective study ,medicine.anatomical_structure ,Impact ,030220 oncology & carcinogenesis ,Female ,Radiology ,medicine.symptom ,Intervertebral disc degeneration ,Abnormalities ,Human ,Adult ,medicine.medical_specialty ,Waist ,Adolescent ,Lumbar vertebra ,Physical Therapy, Sports Therapy and Rehabilitation ,X-ray computed ,Lumbar vertebrae ,Follow-up studies ,Major clinical study ,Article ,Multidetector computed tomography ,03 medical and health sciences ,Disease association ,medicine ,Computer assisted tomography ,Humans ,X-ray computed tomography ,Macromastia ,Intervertebral discs ,business.industry ,Hypertrophy ,Follow up ,Degenerative spondylosis ,medicine.disease ,Retrospective studies ,Orthopedics ,Young adult ,Gigantomastia ,Methodology ,Nipples ,Spondylosis ,Thoracic spine ,business ,Tomography, X-Ray Computed ,Complication - Abstract
The main reason for waist and back pain in patients with gigantomasty is increased thoracic kyphosis and lumber lordosis. These symptoms and abnormal spinal angulations regress after reduction mammoplasty operations. However, the effect of chronic mechanical stress caused by gigantomasty on the spinal degenerative process is not clear yet. In this study with computed tomography it is shown that degenerative spondylosis is more widespread and severe in patients with large breasts. © 2017 - IOS Press and the authors. All rights reserved.
- Published
- 2017
43. Clinical observation on combination of acupuncture and medication in treating breast hyperplasia
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Li Zhou
- Subjects
medicine.medical_specialty ,genetic structures ,Fibrocystic Breast Disease ,business.industry ,Breast Hyperplasia ,Alternative medicine ,Complementary and alternative medicine ,Internal medicine ,Acupuncture ,Physical therapy ,Acupuncture therapy ,Medicine ,Clinical efficacy ,skin and connective tissue diseases ,business - Abstract
Objective To observe the clinical efficacy of acupuncture combined with medication in treating breast hyperplasia.
- Published
- 2014
44. A Humanized Pattern of Aromatase Expression Is Associated with Mammary Hyperplasia in Mice
- Author
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Timothy D. Veenstra, Xia Xu, Francesco J. DeMayo, Masashi Demura, John S. Coon, Hong Zhao, David C. Brooks, Serdar E. Bulun, Ming Zhang, Elizabeth Pearson, Dong Chen, Robert T. Chatterton, and Charles V. Clevenger
- Subjects
medicine.medical_specialty ,Time Factors ,medicine.drug_class ,Blotting, Western ,Mammary gland ,Breast Hyperplasia ,Adipose tissue ,Mice, Transgenic ,Gene Expression Regulation, Enzymologic ,Mice ,Aromatase ,Mammary Glands, Animal ,Endocrinology ,Internal medicine ,STAT5 Transcription Factor ,medicine ,Animals ,Humans ,Phosphorylation ,Promoter Regions, Genetic ,General Endocrinology ,Regulation of gene expression ,Hyperplasia ,biology ,Reverse Transcriptase Polymerase Chain Reaction ,Gene Expression Profiling ,Ovary ,Myoepithelial cell ,Estrogens ,medicine.disease ,Immunohistochemistry ,medicine.anatomical_structure ,Estrogen ,biology.protein ,Female - Abstract
Aromatase is essential for estrogen production and is the target of aromatase inhibitors, the most effective endocrine treatment for postmenopausal breast cancer. Peripheral tissues in women, including the breast, express aromatase via alternative promoters. Female mice lack the promoters that drive aromatase expression in peripheral tissues; thus, we generated a transgenic humanized aromatase (Aromhum) mouse line containing a single copy of the human aromatase gene to study the link between aromatase expression in mammary adipose tissue and breast pathology. Aromhum mice expressed human aromatase, driven by the proximal human promoters II and I.3 and the distal promoter I.4, in breast adipose fibroblasts and myoepithelial cells. Estrogen levels in the breast tissue of Aromhum mice were higher than in wild-type mice, whereas circulating levels were similar. Aromhum mice exhibited accelerated mammary duct elongation at puberty and an increased incidence of lobuloalveolar breast hyperplasia associated with increased signal transducer and activator of transcription-5 phosphorylation at 24 and 64 wk. Hyperplastic epithelial cells showed remarkably increased proliferative activity. Thus, we demonstrated that the human aromatase gene can be expressed via its native promoters in a wide variety of mouse tissues and in a distribution pattern nearly identical to that of humans. Locally increased tissue levels, but not circulating levels, of estrogen appeared to exert hyperplastic effects on the mammary gland. This novel mouse model will be valuable for developing tissue-specific aromatase inhibition strategies.
- Published
- 2012
45. Overexpression of a novel cell cycle regulator ecdysoneless in breast cancer: a marker of poor prognosis in HER2/neu-overexpressing breast cancer patients
- Author
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Hamid Band, Andrew R. Green, Subodh M. Lele, Jun Hyun Kim, Vimla Band, Aditya Bele, Ying Zhang, Alaa T. Alshareeda, Emad A. Rakha, Sameer Mirza, William W. West, Shakur Mohibi, Ian O. Ellis, Monica Goswami, Fang Qiu, Channabasavaiah B. Gurumurthy, and Xiangshan Zhao
- Subjects
Oncology ,Cancer Research ,genetic structures ,Receptor, ErbB-2 ,Gene Expression ,Kaplan-Meier Estimate ,HER2/neu ,Cohort Studies ,Preclinical Study ,Breast cancer ,0302 clinical medicine ,Antibody Specificity ,Breast ,skin and connective tissue diseases ,0303 health sciences ,biology ,Carcinoma, Ductal, Breast ,Middle Aged ,Hyperplasia ,Prognosis ,3. Good health ,Receptors, Estrogen ,030220 oncology & carcinogenesis ,Nottingham Prognostic Index ,Female ,Receptors, Progesterone ,Adult ,medicine.medical_specialty ,Mitotic index ,DCIS ,Adolescent ,Breast Hyperplasia ,Breast Neoplasms ,Cell cycle ,Disease-Free Survival ,Young Adult ,03 medical and health sciences ,Internal medicine ,Ecdysoneless ,Biomarkers, Tumor ,medicine ,Carcinoma ,Humans ,Aged ,030304 developmental biology ,business.industry ,Ductal carcinoma ,medicine.disease ,Carcinoma, Intraductal, Noninfiltrating ,biology.protein ,IDC ,Carrier Proteins ,business - Abstract
Uncontrolled proliferation is one of the hallmarks of breast cancer. We have previously identified the human Ecd protein (human ortholog of Drosophila Ecdysoneless, hereafter called Ecd) as a novel promoter of mammalian cell cycle progression, a function related to its ability to remove the repressive effects of Rb-family tumor suppressors on E2F transcription factors. Given the frequent dysregulation of cell cycle regulatory components in human cancer, we used immunohistochemistry of paraffin-embedded tissues to examine Ecd expression in normal breast tissue versus tissues representing increasing breast cancer progression. Initial studies of a smaller cohort without outcomes information showed that Ecd expression was barely detectable in normal breast tissue and in hyperplasia of breast, but high levels of Ecd were detected in benign breast hyperplasia, ductal carcinoma in situ (DCIS) and infiltrating ductal carcinoma (IDCs) of the breast. In this cohort of 104 IDC patients, Ecd expression levels showed a positive correlation with higher grade (P = 0.04). Further analyses of Ecd expression using a larger, independent cohort (954) confirmed these results, with a strong positive correlation of elevated Ecd expression with higher histological grade (P = 0.013), mitotic index (P = 0.032), and Nottingham Prognostic Index score (P = 0.014). Ecd expression was positively associated with HER2/neu (P = 0.002) overexpression, a known marker of poor prognosis in breast cancer. Significantly, increased Ecd expression showed a strong positive association with shorter breast cancer specific survival (BCSS) (P = 0.008) and disease-free survival (DFS) (P = 0.003) in HER2/neu overexpressing patients. Taken together, our results reveal Ecd as a novel marker for breast cancer progression and show that levels of Ecd expression predict poorer survival in Her2/neu overexpressing breast cancer patients. Electronic supplementary material The online version of this article (doi:10.1007/s10549-011-1946-8) contains supplementary material, which is available to authorized users.
- Published
- 2012
46. The Internal Mammary Artery Perforator (IMAP) Breast-Flap Harvested From an Asymmetric Hyperplastic Breast for Correction of a Mild Funnel Chest Deformity
- Author
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Barbara Del Frari, Reinhard Pauzenberger, Anton H. Schwabegger, and Hildegunde Piza-Katzer
- Subjects
medicine.medical_specialty ,Esthetics ,Mammaplasty ,Breast surgery ,medicine.medical_treatment ,Breast Hyperplasia ,Risk Assessment ,Surgical Flaps ,Young Adult ,Pectus excavatum ,medicine ,Deformity ,Humans ,Breast ,Mammary Arteries ,Funnel Chest ,business.industry ,medicine.disease ,Surgery ,Plastic surgery ,Treatment Outcome ,medicine.anatomical_structure ,Concomitant ,Tissue and Organ Harvesting ,Female ,Radiology ,medicine.symptom ,business ,Thoracic wall ,Follow-Up Studies - Abstract
Pectus excavatum deformity is the most frequent congenital anomaly of the thoracic wall. If the invasive surgical procedures of thoracoplasty are not indicated or the patient refuses them, alternative treatment options should be considered. In such cases, local or distant transposition of autologous tissue could be appropriate. This report presents a selected case of funnel chest deformity and concomitant unilateral breast hyperplasia. Both deformities were corrected simultaneously using a pedicled internal mammary artery perforator (IMAP) flap dissected from the hyperplastic breast. This is a safe, reliable, low-morbidity, one-stage option for adult women that uses an easy-to-harvest flap for simultaneous correction of mild funnel chest deformity and concomitant breast hyperplasia with a single resulting scar.
- Published
- 2011
47. 2D-DIGE Proteomic Analysis of Changes in Estrogen/Progesterone-Induced Rat Breast Hyperplasia upon Treatment with the Mongolian Remedy RuXian-I
- Author
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Du E, De-Ligen Batu, Zhong-Chao Wang, Bin Zhang, Ya-Latu Saixi, and Li-Qun Ren
- Subjects
medicine.medical_specialty ,medicine.drug_class ,Breast Hyperplasia ,Pharmaceutical Science ,Article ,Analytical Chemistry ,Metastasis ,Superoxide dismutase ,lcsh:QD241-441 ,Breast cancer ,Mammary Glands, Animal ,proteomics ,lcsh:Organic chemistry ,Internal medicine ,Drug Discovery ,estrogen ,Medicine ,Animals ,Electrophoresis, Gel, Two-Dimensional ,rat ,Physical and Theoretical Chemistry ,Progesterone ,breast hyperplasia ,Hyperplasia ,biology ,business.industry ,Organic Chemistry ,Estrogens ,medicine.disease ,Rats ,Endocrinology ,Chemistry (miscellaneous) ,Estrogen ,Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ,biology.protein ,Molecular Medicine ,2D-DIGE ,Female ,business ,Annexin A2 ,Annexin A1 ,Drugs, Chinese Herbal ,Mongolian medicine - Abstract
RuXian-I has traditionally been used as a remedy for breast hyperplasia in the Inner Mongolia Autonomous Region of China. As a first step toward the investigation of biomarkers associated with RuXian-I treatment, a proteome-wide analysis of rat breast tissue was conducted. First, rat breast hyperplasia was induced by injection of estradiol and progesterone. After treatment with RuXian-I, there is a marked decrease in the hyperplasia, as can be shown by decreases in the nipple diameter and the pathological changes in breast. Subsequently, we used an approach that integrates size-based 2D-DIGE, MALDI-TOF/TOF-MS, and bioinformatics to analyze data from the control group, the model group and the RuXian-I treatment group. Using this approach, seventeen affected proteins were identified. Among these, 15 (including annexin A1, annexin A2, superoxide dismutase [Mn], peroxiredoxin-1, translationally-controlled tumor protein and a B-crystallin) were significantly up-regulated in the model group and down-regulated upon treatment with RuXian-I, and two (Tpil protein and myosin-4) have the opposite change trend. The expression of annexin A1 was confirmed using immunohistochemistry. The expression of superoxide dismutase (SOD) activity was confirmed biochemically. These results indicated that RuXian-I treats rat breast hyperplasia through regulation of cell cycle, immune system, metabolic, signal transduction, etc. The differential expressions of these proteins (annexin A1, superoxide dismutase [Mn], alpha B-crystallins and translationally controlled tumor protein, among others) were associated with occurrence and metastasis of breast cancer. These findings might provide not only far-reaching valuable insights into the mechanism of RuXian-I action, but also leads for prognosis and diagnosis of breast hyperplasia and breast cancer.
- Published
- 2011
48. PTEN mutation spectrum in breast cancers and breast hyperplasia
- Author
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BaoLin Li, Ju-Lun Yang, Fang Dai, Yan Ren, Li Wang, Yue Chen, Wenxing Zhao, Tao Li, and Wen-Mang Xu
- Subjects
Adult ,Cancer Research ,Breast Hyperplasia ,Breast Neoplasms ,Gene mutation ,medicine.disease_cause ,Polymerase Chain Reaction ,Breast cancer ,medicine ,Humans ,Tensin ,PTEN ,skin and connective tissue diseases ,In Situ Hybridization, Fluorescence ,Aged ,Hyperplasia ,biology ,PTEN Phosphohydrolase ,Cancer ,Sequence Analysis, DNA ,General Medicine ,Middle Aged ,medicine.disease ,Immunohistochemistry ,Oncology ,Mutation ,Cancer research ,biology.protein ,Female ,Breast disease ,Carcinogenesis - Abstract
Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is one of the most frequently mutated human tumor suppressor genes. The present study aims to investigate the role of PTEN mutation in breast carcinogenesis by analyzing PTEN mutation spectrum and the protein expression in breast cancers, adjacent hyperplastic lesions, benign breast lesions and normal breast tissues. All 9 exons of PTEN gene were amplified by PCR with DNA extracted from 50 of human breast cancers and corresponding adjacent breast hyperplasia tissues, adjacent normal breast tissues, as well as 50 breast benign lesions residing in or around Yunnan, China, respectively. PCR products were then sequenced for mutation screening. And we also proved the effect of mutations on the expression of PTEN protein by immunohistochemistry. PTEN mutations were detected in 11 of 50 (22%) breast cancers and 4 of 50 (8%) adjacent ductal hyperplasia, all of which were atypical ductal hyperplasia and same PTEN mutation were detected in the corresponding cancer tissues. No PTEN mutation was detected in all adjacent normal breast tissues and 50 cases of breast benign lesions. The mutation sites concentrated at exon 3, 4, 5 and 7; no mutation was detected in exon 1, 2, 6, 8, or 9 and splicing sites of all introns. The hottest mutation spots were exon 5 with missense mutations. Immunohistochemical analysis showed that 24 of 50 (48%) breast cancers and 6 of 50 (12%) adjacent breast hyperplasia demonstrated negative immuno-staining of PTEN (loss of PTEN protein expression). All the 4 adjacent breast tissues harbored PTEN mutations and 9 of 11 breast cancers with PTEN mutation were loss of PTEN expression. Statistical analysis revealed that PTEN gene mutations were correlated with the PTEN expression. The incidence of PTEN mutations is relatively high in patients with sporadic breast cancer in the region of Yunnan, China and exists at the early stage of breast cancer development. The PTEN mutations have significant effect on the expression silencing of PTEN protein indicating the important role of PTEN mutation in carcinogenesis of breast cancers.
- Published
- 2010
49. Angiogenesis is associated with the onset of hyperplasia in human ductal breast disease
- Author
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Malcolm W.R. Reed, Simon S. Cross, Nicola J. Brown, Sabapathy P. Balasubramanian, Carolyn A. Staton, S.E. Higham, Joanne E. Bluff, and S R Menakuru
- Subjects
Vascular Endothelial Growth Factor A ,CD31 ,Cancer Research ,Pathology ,medicine.medical_specialty ,Angiogenesis ,Breast Hyperplasia ,HIF-1α ,Breast Neoplasms ,Thromboplastin ,Neovascularization ,angiogenesis ,breast cancer ,Breast cancer ,Biomarkers, Tumor ,medicine ,Humans ,Molecular Diagnostics ,Cell Proliferation ,Hyperplasia ,Neovascularization, Pathologic ,business.industry ,Carcinoma, Ductal, Breast ,Endothelial Cells ,Endoglin ,tissue factor ,Hypoxia-Inducible Factor 1, alpha Subunit ,Prognosis ,medicine.disease ,VEGF ,Immunohistochemistry ,Carcinoma, Intraductal, Noninfiltrating ,Oncology ,Female ,Breast disease ,medicine.symptom ,business ,Precancerous Conditions - Abstract
BACKGROUND: The precise timing of the angiogenic switch and the role of angiogenesis in the development of breast malignancy is currently unknown. METHODS: Therefore, the expression of CD31 (pan endothelial cells (ECs)), endoglin (actively proliferating ECs), hypoxia-inducible factor-1 (HIF-1alpha), vascular endothelial growth factor-A (VEGF) and tissue factor (TF) were quantified in 140 surgical specimens comprising normal human breast, benign and pre-malignant hyperplastic tissue, in situ and invasive breast cancer specimens. RESULTS: Significant increases in angiogenesis (microvessel density) were observed between normal and benign hyperplastic breast tissue (P
- Published
- 2009
50. NOEY2 mutations in primary breast cancers and breast hyperplasia
- Author
-
Ju-Lun Yang, Wen-Mang Xu, Li Wang, Yue Chen, Wenxing Zhao, AiPing Hu, Tao Li, and BaoLin Li
- Subjects
Adult ,rho GTP-Binding Proteins ,DNA Mutational Analysis ,Breast Hyperplasia ,Breast Neoplasms ,Gene mutation ,medicine.disease_cause ,Polymerase Chain Reaction ,Atypical hyperplasia ,Frameshift mutation ,Exon ,Breast cancer ,medicine ,Humans ,Neoplasm Invasiveness ,skin and connective tissue diseases ,Aged ,Mutation ,Hyperplasia ,business.industry ,Cancer ,General Medicine ,Middle Aged ,medicine.disease ,Immunohistochemistry ,Gene Expression Regulation, Neoplastic ,Cancer research ,Female ,Surgery ,business - Abstract
Purpose The NOEY2 gene mutations and protein expression in human breast cancers, adjacent breast tissues and breast benign lesions were analysed to explore the potential correlation between the mutation spectrum and breast cancer development and progression. Experimental design The promoter, exon and intron regions of NOEY2 gene were amplified by polymerase chain reaction (PCR) with DNA extracted from 50 human breast cancer and corresponding adjacent breast tissues as well as 50 breast benign lesions, respectively. The PCR products were then sequenced and analysed. The effect of mutations on the expression of NOEY2 protein by immunohistochemistry were proven as well. Results Twenty-one of 50 (42%) breast cancer mutations were identified in promoter (11 cases) and exon 2 (seven cases on untranslation region and three on coding region) and 17 of 50 (34%) adjacent breast tissues (all were atypical hyperplasia lesions) occurred mutations, including six promoter mutations and 11 exon 2 changes (10 cases on untranslation region and one on coding region). Interestingly, the mutations were identified in both breast cancers and the corresponding adjacent breast tissues collected from the same patient in seven of them. No mutation was identified in all benign breast tissues. Immunohistochemical analysis showed that two of 17 mutational adjacent breast tissue samples were NOEY2 immunoreaction negative, and in all 21 mutations of breast cancers five cases were of loss of NOEY2 expression. All mutations with immunoreaction negative factor were located at promoter and/or exon 2 coding region. NOEY2 gene mutations were not correlated with patient ages, histological types, tumour sizes, histological grades, clinical stages, axillary lymph node metastases or with the condition of hormone receptor (ER, PR) expression and HER2 amplification. Conclusions The mutations of human NOEY2 were identified in human breast cancers and the corresponding adjacent breast tissues. The hot mutation spots were its promoter and exon 2 regions, and those occurring at the exon2 coding region and part of the promoter may alter the expression of NOEY2. The presence of NOEY2 mutations in human breast cancer and early-stage lesions indicates that NOEY2 mutations may be partly associated with breast tumourigenesis.
- Published
- 2009
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