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Melatonin inhibits cell proliferation in a rat model of breast hyperplasia by mediating the PTEN/AKT pathway
- Source :
- Oncology Reports
- Publication Year :
- 2021
- Publisher :
- D.A. Spandidos, 2021.
-
Abstract
- In the present study, a rat model of breast hyperplasia was established via the administration of estradiol benzoate and progesterone. Subsequent changes associated with breast hyperplasia were then investigated by measuring the diameter and height of the nipples and by staining breast tissue with hematoxylin and eosin. The proliferation and apoptosis of hyperplastic cells in the breast tissue were then determined by analyzing the expression of proliferating cell nuclear antigen (PCNA) and cleaved-caspase-3 by immunohistochemistry and TUNEL staining. We also determined the expression of proteins associated with the phosphatase and tensin homolog (PTEN)/protein kinase B (AKT) signaling pathway by western blotting. Melatonin treatment led to a significant reduction in the degree of breast hyperplasia (P
- Subjects :
- 0301 basic medicine
Cancer Research
Breast Hyperplasia
melatonin
Melatonin
Random Allocation
03 medical and health sciences
Mammary Glands, Animal
0302 clinical medicine
hyperplastic disease of the breast
Proliferating Cell Nuclear Antigen
medicine
Animals
Tensin
PTEN
Rats, Wistar
skin and connective tissue diseases
Protein kinase B
PI3K/AKT/mTOR pathway
Cell Proliferation
breast hyperplasia
Hyperplasia
biology
Chemistry
PTEN/AKT pathway
PTEN Phosphohydrolase
General Medicine
Articles
mammary gland hyperplasia
Immunohistochemistry
Rats
Proliferating cell nuclear antigen
Disease Models, Animal
030104 developmental biology
Oncology
Apoptosis
030220 oncology & carcinogenesis
Cancer research
biology.protein
Female
Proto-Oncogene Proteins c-akt
Signal Transduction
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 17912431 and 1021335X
- Volume :
- 45
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Oncology Reports
- Accession number :
- edsair.doi.dedup.....57d17a254aff5f0e2a9c21ad806e3c12