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2,135 results on '"Bradbury, J"'

1. When morphology and molecular markers conflict: a case history of subterranean amphipods from the Pilbara, Western Australia

Author

Finston, T. L., Bradbury, J. H., Johnson, M. S., and Knott, B.

Subjects
Conservation, Genetics, Morphology, Species, Amphipods, Zoology, QL1-991
Abstract

Fifteen species of groundwater amphipods in the genus Chydaekata have been described from the Pilbara, Western Australia, each restricted to a single bore. Dewatering at a local mine site was halted while a second survey was undertaken. Newly collected samples were identified using the existing key, and allozyme analysis was used to test species boundaries. Allozymic diversity was not associated with single bores, and only two distinctgenetic groups (one of which was very rare), were identified. Based on these results, and the finding that species were found to be more widespread, the Western Australian Environmental Protection Authority recommended that dewatering continue with caution at the site. This study provides an example of the problems associated with incongruent data sets, and the difficulties inherent in working with rare species, namely, interpreting the results of studies based on small samples or incomplete collections.

Published
2004

3. attenuates allergic lung inflammation through regulation of Th2, Th9, and Treg differentiation

Author

Li, Hong, Bradbury, J. Alyce, Edin, Matthew L., Gruzdev, Artiom, Li, Huiling, Graves, Joan P., DeGraff, Laura M., Lih, Fred B., Feng, Chiguang, Wolf, Erin R., Bortner, Carl D., London, Stephanie J., Sparks, Matthew A., Coffman, Thomas M., and Zeldin, Darryl C.

Subjects
Care and treatment, Physiological aspects, Development and progression, Health aspects, Thromboxanes -- Physiological aspects -- Health aspects, Asthma -- Development and progression -- Prevention -- Care and treatment, Immune response -- Health aspects -- Physiological aspects
Abstract

Introduction Development of allergic lung inflammation is a complex process involving both immune and inflammatory events. In the immune phase, allergens are taken up and processed by antigen-presenting cells such [...], In lung, thromboxane [A.sub.2] ([TXA.sub.2]) activates the TP receptor to induce proinflammatory and bronchoconstrictor effects. Thus, TP receptor antagonists and [TXA.sub.2] synthase inhibitors have been tested as potential asthma therapeutics in humans. Th9 cells play key roles in asthma and regulate the lung immune response to allergens. Herein, we found that [TXA.sub.2] reduces Th9 cell differentiation during allergic lung inflammation. Th9 cells were decreased approximately 2-fold and airway hyperresponsiveness was attenuated in lungs of allergic mice treated with [TXA.sub.2]. Naive [CD4.sup.+] T cell differentiation to Th9 cells and IL-9 production were inhibited dose-dependently by [TXA.sub.2] in vitro. TP receptor-deficient mice had an approximately 2-fold increase in numbers of Th9 cells in lungs in vivo after OVA exposure compared with wild-type mice. Naive [CD4.sup.+] T cells from TP- deficient mice exhibited increased Th9 cell differentiation and IL-9 production in vitro compared with [CD4.sup.+] T cells from wild-type mice. [TXA.sub.2] also suppressed Th2 and enhanced Treg differentiation both in vitro and in vivo. Thus, in contrast to its acute, proinflammatory effects, [TXA.sub.2] also has longer-lasting immunosuppressive effects that attenuate the Th9 differentiation that drives asthma progression. These findings may explain the paradoxical failure of anti-thromboxane therapies in the treatment of asthma.

Published
2024
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6. Cryogenically cooled periodically poled lithium niobate wafer stacks for multi-cycle terahertz pulses.

Author

Dalton, P. J., Shaw, C. T., Bradbury, J. T., Mosley, C. D. W., Sharma, A., Gupta, V., Bohus, J., Gupta, A., Son, J.-G., Fülöp, J. A., Appleby, R. B., Burt, G., Jamison, S. P., Hibberd, M. T., and Graham, D. M.

Abstract

We report on the generation of high-power narrow-bandwidth terahertz (THz) pulses by cryogenic cooling of hand-made periodically poled lithium niobate (PPLN) wafer stacks. As a proof-of-concept, we cool stacks with up to 48 wafers down to 97 K and achieve few-percent bandwidths at a center frequency of 0.39 THz, with pulse energy up to 0.42 mJ and average power of 21 mW. Supported by modeling, we observe effective cooling of PPLN wafer stacks that not only reduces terahertz absorption but critically maintains the micrometer-scale inter-wafer gaps for optimal terahertz transmission. Our results unlock the potential for scaling these large-area sources to greater numbers of wafers to push both the energy and bandwidth beyond current capability, opening up possibilities in areas such as terahertz-driven particle acceleration, terahertz imaging, and control over material properties. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Lifetime measurements using a plunger device and the EUCLIDES Si array at the GALILEO [formula omitted]-ray spectrometer

Author

Bradbury, J., Testov, D., Bakes, S., Goasduff, A., Mengoni, D., Valiente-Dobón, J.J., de Angelis, G., Bazzacco, D., Boiano, C., Boso, A., Cederwall, B., Cicerchia, M., Colucci, G., Čolović, P., Didierjean, F., Doncel, M., Dueñas, J.A., Galtarossa, F., Gozzelino, A., Hadyńska-Klȩk, K., Jaworski, G., John, P.R., Liu, H., Lenzi, S., Lunardi, S., Menegazzo, R., Mentana, A., Müller-Gatermann, C., Napoli, D.R., Pasqualato, G., Recchia, F., Rocchini, M., Riccetto, S., Saygi, B., Siciliano, M., Sobolev, Yu., and Szilner, S.

Published
2020
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8. TXA2 attenuates allergic lung inflammation through regulation of Th2, Th9 and Treg differentiation

Author

Li, Hong, primary, Bradbury, J. Alyce, additional, Edin, Matthew L., additional, Gruzdev, Artiom, additional, Li, Huiling, additional, Graves, Joan P., additional, DeGraff, Laura M., additional, Lih, Fred B., additional, Feng, Chiguang, additional, Wolf, Erin R., additional, Bortner, Carl D., additional, London, Stephanie J., additional, Sparks, Matthew A., additional, Coffman, Thomas M., additional, and Zeldin, Darryl C., additional

Published
2024
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10. Sinus Surgery Is Associated with a Decrease in Aspirin-Induced Reaction Severity in Patients with Aspirin Exacerbated Respiratory Disease

Author

Jerschow, Elina, Edin, Matthew L., Chi, Yuling, Hurst, Beth, Abuzeid, Waleed M., Akbar, Nadeem A., Gibber, Marc, Fried, Marvin P., Han, Weiguo, Pelletier, Teresa, Ren, Zhen, Keskin, Taha, Roizen, Gigia, Lih, Fred B., Gruzdev, Artiom, Bradbury, J. Alyce, Schuster, Victor, Spivack, Simon, Rosenstreich, David, and Zeldin, Darryl C.

Published
2019
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11. The presentation, management and outcome of inflammatory breast cancer cases in the UK: Data from a multi-centre retrospective review

Author

Copson, E., Shaaban, A.M., Maishman, T., Moseley, P.M., McKenzie, H., Bradbury, J., Borley, A., Brzezinska, M., Chan, S.Y.T., Ching, J., Cutress, R.I., Danial, I., Dall, B., Kerin, M., Lowery, A.J., Macpherson, I.R., Romics, L., Sawyer, E., Sharmat, N., Sircar, T., Vidya, R., Pan, Y., Rea, D., Jones, L., Eccles, D.M., and Berditchevski, F.

Published
2018
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20. International Consensus Definition of Low Anterior Resection Syndrome

Author

Keane, Celia, Fearnhead, Nicola S., Bordeianou, Liliana G., Christensen, Peter, Basany, Eloy Espin, Laurberg, Søren, Mellgren, Anders, Messick, Craig, Orangio, Guy R., Verjee, Azmina, Wing, Kirsty, Bissett, Ian, An, V, Bryant, A, Byrne, C, Chen, T, Croft, S, Clark, D, Gladman, M, Heriot, A, Kariappa, S, Keck, J, Lubowski, D, Dinning, P, Khera, A, Kirkwood, K, Petersen, D, Sloots, K, Totten, B, Weston, M, Andersen, P, Bachmann, C, Barht, H, Emmertsen, K, Faaborg, P, Gögenur, I, Ingerslev, P, Isaksen, D, Iversen, H, Iversen, L, Jacobsen, K, Jansen, T, Jocobsen, I, Juul, T, Kjar, D, Krogh, K, Majgaard, M, Mynster, A, Neuenschwander, A, Nielsen, C, Nielsen, R, Nielsen, M, Nielsen, T, Olsen, J, Poulsen, B, Rahr, H, Snedker, B, Sørensen, G, Stolzenburg, T, Vaabengaard, P, Acheson, A, Andreyev, J, Bach, S, Battersby, N, Bradbury, J, Brown, S, Cecil, T, Chapman, S, Chapman, M, Chave, H, Cook, T, Cuffy, L, Davies, J, Dawson, C, Dixon, J, Duff, S, Edwards, C, Geh, I, Hamilton, C, Hancock, L, Harji, D, Hill, J, Holtham, S, Jenkins, J, Johnston, R, Kapur, S, Maxwell-Armstrong, C, McArthur, D, Moran, B, Norton, C, Nugent, K, Pateman, L, Perston, Y, Rockall, T, Sagar, P, Saunders, M, Sebag-Montefiore, D, Senapati, A, Singh, B, Skaife, P, Sykes, H, Smart, N, Taylor, C, Thorpe, G, Tierney, G, Voyce, S, Walsh, C, Warren, O, Wheeler, J, Woodward, A, Winter, D, Abbott, S, Beban, V, Bennett, M, Chadwick, T, Collinson, R, Corbett, S, Dennett, E, Eglinton, T, Fraser, A, Glue, J, Hohaia, D, Menzi, E, O’Connor, M, Stevenson, D, Wells, C, Wolyncewicz, S, Woodfield, J, Bence, K, Boutros, M, Brueseke, M, DeKorte, J, Floruta, C, Francone, T, Frederick, F, Grasso, J, Gurland, B, Higgins, K, Hull, T, Keller, D, Laffan, A, Lovett, S, Marlatt, J, McAdams, D, McCarthy, C, Milch, H, Natale, S, Pappou, E, Paquette, I, Pulskamp, S, Rich, M, Savitt, L, Shafi, M, Steele, S, Stein, S, Tolbert, M, Varma, M, Vogler, S, Vuong, T, Wells, K, Wexner, S, Wo, J, Wright, J, Wunderlich, C, Campbell, K, Lim, M, Moug, S, Oliphant, R, Labaka-Aretaga, I, Ballester, C, Belen-Bueno, A, Vaquer-Casas, G, Jerez, J, Castillo, J, Paniagua-Cayetano, G, Codina-Cazador, A, Blanco-Colino, R, de la Portilla, F, Pascual-Damieta, M, Enriquez-Navascuez, JM, Martin-Fernández, M, Araujo-Ferreiro, M, Sanchez-García, C, Vico-García, E, Gallego-García, M, Jimenez, LM, Martinez-Sanchez, C, Carrillo-Moreno, J, Muñoz, A, Ramirez, L, Vigorita, V, Adams, R, Cornish, J, Davies, M, Evans, M, Torkington, J, and Turner, J

Published
2020
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22. sEH promotes macrophage phagocytosis and lung clearance of Streptococcus pneumoniae

Author

Li, Hong, Bradbury, J. Alyce, Edin, Matthew L., Graves, Joan P., Gruzdev, Artiom, Cheng, Jennifer, Hoopes, Samantha L., DeGraff, Laura M., Fessler, Michael B., Garantziotis, Stavros, Schurman, Shepherd H., and Zeldin, Darryl C.

Subjects
Care and treatment, Physiological aspects, Development and progression, Health aspects, Streptococcus pneumoniae -- Physiological aspects, Macrophages -- Health aspects -- Physiological aspects, Hydrolases -- Health aspects -- Physiological aspects, Phagocytosis -- Health aspects -- Physiological aspects, Pneumococcal infections -- Care and treatment -- Development and progression, Lung diseases -- Care and treatment -- Development and progression, Enzymes -- Health aspects -- Physiological aspects
Abstract

Introduction Pneumonia is the leading cause of mortality in the United States Streptococcus pneumoniae and Klebsiella pneumoniae are the mosi frequently isolated bacterial pathogens in community-acquirec pneumonia (1). Together, these [...], Epoxyeicosatrienoic acids (EETs) have potent antiinflammatory properties. Hydrolysis of EETs by soluble epoxide hydrolase/ epoxide hydrolase 2 (sEH/EPHX2) to less active diols attenuates their antiinflammatory effects. Macrophage activation is critical to many inflammatory responses; however, the role of EETs and sEH in regulating macrophage function remains unknown. Lung bacterial clearance of Streptococcus pneumoniae was impaired in Ephx2-deficient ([Ephx2.sup.-/-]) mice and in mice treated with an sEH inhibitor. The EET receptor antagonist EEZE restored lung clearance of S. pneumoniae in Ephx2 /mice. [Ephx2.sup.-/-] mice had normal lung Il1b, Il6, and Tnfa expression levels and macrophage recruitment to the lungs during S. pneumoniae infection; however, Ephx2 disruption attenuated proinflammatory cytokine induction, Tlr2 and Pgylrp1 receptor upregulation, and Ras-related C3 botulinum toxin substrates 1 and 2 (Rac1/2) and cell division control protein 42 homolog (Cdc42) activation in PGN-stimulated macrophages. Consistent with these observations, [Ephx2.sup.-/-] macrophages displayed reduced phagocytosis of S. pneumoniae in vivo and in vitro. Heterologous overexpression of TLR2 and peptidoglycan recognition protein 1 (PGLYRP1) in [Ephx2.sup.-/-] macrophages restored macrophage activation and phagocytosis. Human macrophage function was similarly regulated by EETs. Together, these results demonstrate that EETs reduced macrophage activation and phagocytosis of S. pneumoniae through the downregulation of TLR2 and PGLYRP1 expression. Defining the role of EETs and sEH in macrophage function may lead to the development of new therapeutic approaches for bacterial diseases.

Published
2021
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27. Identification of Extracolonic Pathologies by Computed Tomographic Colonography in Colorectal Cancer Symptomatic Patients

Author

Dadswell, E., Kanani, R., Wooldrage, K., Rogers, P., Shah, U., Kralj-Hans, I., Ghanouni, A., Waddingham, J., Pack, K., Thomson, A., Turner, L., Monk, C., Verjee, A., Smith, S., von Wagner, C., Wardle, J., Lilford, R.J., Yao, G., Zhu, S., Burling, D., Higginson, A., Kay, C.L., Maskell, G.F., Taylor, A., Hayward, S.J., Cade, D., Morton, D., Dhingsa, R., Jobling, J.C., Jackson, S.A., Blunt, D., Neelala, M.K., Sukumar, S.A., Slater, A., Ziprin, P., Edwards, D., Woolfall, P., Muckian, J., Bastable, D., Gibbons, N., Flashman, K., Coni, L., Martin, J., Stephenson, S., Jackson, C., Beech, D., Lynn, C., Arumugam, H., Wilkinson, S., Scothern, J., Pickles, L., Hennedy, A., Larkin, T., Pearson, P., Preston, S., Smith, L., Wright, L., Blackstock, J., Thomas, R., Allen, S., Young, L., Adamson, V., Butler-Barnes, J., Larcombe, T., Bradshaw, V., Chapman, S., Slater, M., Stylan, J., Wood, D., Bradbury, J., Breedon, J., Coakes, M., Crutch, L., Leyland, A., Pringle, W., Rowe, L., White, M., Kumar, D., Worley, A., Gandy, M., Whitehead, E., Pascoe, J., Avery, M., Shivapatham, D., Thomas, S., Ong, C., Poppinga-Scholz, B., Stove, J., Pearson, K., Wood, J., Cook, W., Memory, Y., Fellows, K., Duffy, A., Usansky, A., Shanahan, B., Naim, F., Bohra, V., Prabhudesai, S., Lancelotte, N., Hayes, M., James, T., Johnston, S., Stevenson, J., Whetter, D., Bartram, C., Gupta, A., Marshall, M., Taylor, S.A., Atchley, J., Lowe, A., Wormald, A., Bloor, C., Tan, E., McGregor, J., Philips, A., Noakes, M., Zaman, S., Guest, P., McCafferty, I., Riley, P., Tattersall, D., Fox, B.M., Shirley, J., Roddie, M., Owen, A., Hughes, N., Northover, J.M.A., Saunders, B., Goggin, P., O’Leary, D., Ausobsky, J., Beckett, C., Davies, J., Griffith, J., Steward, M., Arumugam, P.J., Bronder, C., Brown, C., Crighton, I., Higham, A., Lea, R., Meaden, C., Morgan, W., Patel, P., Nasmyth, G., Williamson, M., Scholefield, J., Hosie, K., Bansi, D., Buchanan, G., Dawson, P., Smith, G., Theodorou, N.A., Thillainayagam, A., Conlong, P., Rameh, B., Rate, A., Richards, D., Hyde, G.M., Jones, D.J., O’Dwyer, S.T., Cunningham, C., Travis, S., Burton, S., Fabricius, P., Gudgeon, M., Jourdan, I., Rutter, M., Dixon, A., Faulds-Wood, L., Marteau, T., Valori, R., Altman, D.G., Steele, R., Walker, A., Halligan, Steve, Wooldrage, Katherine, Dadswell, Edward, Shah, Urvi, Kralj-Hans, Ines, von Wagner, Christian, Faiz, Omar, Teare, Julian, Edwards, Rob, Kay, Clive, Yao, Guiqing, Lilford, Richard J., Morton, Dion, Wardle, Jane, and Atkin, Wendy

Published
2015
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40. Academic Performance of English First and Second-Language Students: A Retrospective Appraisal.

Author

Miller, R., Bradbury, J., and Acutt, K.

Abstract

Investigated the long-term academic effects of a first-year foundation course designed to enhance the academic performance of university students. Found that third-year academic performance is not simply a function of initial language and mathematics competence levels; those who improved performance in the foundation course tended to perform well as third-year students. (EV)

Published
2001

44. Academic Performance of First and Second Language Students: Kinds of Assessment.

Author

Miller, R., Bradbury, J., and Wessels, S. L.

Abstract

A study of 543 South African university freshmen examined testing issues in relation to use of English as a first or second language. Results suggest multiple-choice tests yield higher grades than essay tests for both native and nonnative speakers, performance on essay questions varies depending on type of question, and open-ended tutorial assessments are reasonable predictors of academic success. (Author/MSE)

Published
1997

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