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1. Substitution of processed meat for fish or poultry and the impact on hypertension in the E3N cohort

Author: Thao, U, primary, Madika, A L, additional, Boutron-Ruault, MC, additional, and MacDonald, CJ, additional
Published: 2021
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2. Association between menopausal hormone therapy, mammographic density and breast cancer risk: results from the E3N cohort study.

Author: Fornili, M, Perduca, V, Fournier, A, Jérolon, A, Boutron-Ruault, MC, Maskarinec, G, Severi, G, Baglietto, L, Fornili, M, Perduca, V, Fournier, A, Jérolon, A, Boutron-Ruault, MC, Maskarinec, G, Severi, G, and Baglietto, L
Abstract: BACKGROUND: Menopausal hormone therapy (MHT) is a risk factor for breast cancer (BC). Evidence suggests that its effect on BC risk could be partly mediated by mammographic density. The aim of this study was to investigate the relationship between MHT, mammographic density and BC risk using data from a prospective study. METHODS: We used data from a case-control study nested within the French cohort E3N including 453 cases and 453 matched controls. Measures of mammographic density, history of MHT use during follow-up and information on potential confounders were available for all women. The association between MHT and mammographic density was evaluated by linear regression models. We applied mediation modelling techniques to estimate, under the hypothesis of a causal model, the proportion of the effect of MHT on BC risk mediated by percent mammographic density (PMD) for BC overall and by hormone receptor status. RESULTS: Among MHT users, 4.2% used exclusively oestrogen alone compared with 68.3% who used exclusively oestrogens plus progestogens. Mammographic density was higher in current users (for a 60-year-old woman, mean PMD 33%; 95% CI 31 to 35%) than in past (29%; 27 to 31%) and never users (24%; 22 to 26%). No statistically significant association was observed between duration of MHT and mammographic density. In past MHT users, mammographic density was negatively associated with time since last use; values similar to those of never users were observed in women who had stopped MHT at least 8 years earlier. The odds ratio of BC for current versus never MHT users, adjusted for age, year of birth, menopausal status at baseline and BMI, was 1.67 (95% CI, 1.04 to 2.68). The proportion of effect mediated by PMD was 34% for any BC and became 48% when the correlation between BMI and PMD was accounted for. These effects were limited to hormone receptor-positive BC. CONCLUSIONS: Our results suggest that, under a causal model, nearly half of the effect of MHT on hormone rec
Published: 2021

3. Associations between smoking and blood-group, and the risk of dyslipidaemia amongst French women.

Author: MacDonald, CJ, Madika, AL, Severi, G, Fournier, A, Boutron-Ruault, MC, MacDonald, CJ, Madika, AL, Severi, G, Fournier, A, and Boutron-Ruault, MC
Abstract: Dyslipidaemia is a major risk factor for cardio-vascular disease, as it promotes atherosclerosis. While cross-sectional studies have identified higher serum cholesterol amongst individuals with the A blood group, there is less evidence from prospective studies whether this translates into a higher risk of dyslipidaemia that requires treatment, nor if this genetic factor interacts with smoking status. This study aimed to prospectively determine potential associations between smoking, ABO blood groups, and risk of incident dyslipidaemia requiring treatment, and to assess associations over strata of blood ABO group. We assessed associations between blood ABO group, smoking and dyslipidaemia in 74,206 women participating in the E3N cohort. We included women who did not have cardiovascular disease at baseline. Logistic regression was used to determine associations between ABO group, smoking and prevalent dyslipidaemia at baseline. Cox proportional hazard models were then used to determine if blood ABO group and smoking were associated with the risk of incident dyslipidaemia, amongst women free of dyslipidaemia at baseline. At baseline 28,281 women with prevalent dyslipidaemia were identified. Compared to the O-blood group, the non-O blood group was associated higher odds of with prevalent dyslipidaemia (ORnon-O = 1.09 [1.06: 1.13]). Amongst the women free of dyslipidaemia at baseline, 6041 incident cases of treated dyslipidaemia were identified during 454,951 person-years of follow-up. The non-O blood groups were associated with an increased risk of dyslipidaemia when compared to the O-group (HRnon-O = 1.16 [1.11: 1.22]), specifically the A blood-group (HRA = 1.18 [1.12: 1.25]). Current smokers were associated with an increased risk of incident dyslipidaemia (HR smokers = 1.27 [1.16: 1.37]), compared to never-smokers. No evidence for effect modification between smoking and ABO blood group was observed (p-effect modification = 0.45), although the highest risk was observed
Published: 2021

4. SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe

Author: Achenbach, S, Aleksandrova, K, Amiano, P, San Sebastian, D, Amouyel, P, Andersson, J, Bakker, S, Da Providencia Costa, R, Beulens, J, Blaha, M, Bobak, M, Boer, J, Bonet, C, Bonnet, F, Boutron-Ruault, M, Braaten, T, Brenner, H, Brunner, F, Brunner, E, Brunström, M, Buring, J, Butterworth, A, Capkova, N, Cesana, G, Chrysohoou, C, Colorado-Yohar, S, Cook, N, Cooper, C, Dahm, C, Davidson, K, Dennison, E, Di Castelnuovo, A, Donfrancesco, C, Dörr, M, Doryńska, A, Eliasson, M, Engström, G, Ferrari, P, Ferrario, M, Ford, I, Fu, M, Gansevoort, R, Giampaoli, S, Gillum, R, Gómez de la Cámara, A, Grassi, G, Hansson, P, Huculeci, R, Hveem, K, Iacoviello, L, Ikram, M, Jørgensen, T, Joseph, B, Jousilahti, P, Wouter Jukema, J, Kaaks, R, Katzke, V, Kavousi, M, Kiechl, S, Klotsche, J, König, W, Kronmal, R, Kubinova, R, Kucharska-Newton, A, Läll, K, Lehmann, N, Leistner, D, Linneberg, A, Pablos, D, Lorenz, T, Lu, W, Luksiene, D, Lyngbakken, M, Magnussen, C, Malyutina, S, Ibañez, A, Masala, G, Mathiesen, E, Matsushita, K, Meade, T, Melander, O, Meyer, H, Moons, K, Moreno-Iribas, C, Muller, D, Münzel, T, Nikitin, Y, Nordestgaard, B, Omland, T, Onland, C, Overvad, K, Packard, C, Pająk, A, Palmieri, L, Panagiotakos, D, Panico, S, Perez-Cornago, A, Peters, A, Pietilä, A, Pikhart, H, Psaty, B, Quarti-Trevano, F, Garcia, J, Riboli, E, Ridker, P, Rodriguez, B, Rodriguez-Barranco, M, Rosengren, A, Roussel, R, Sacerdote, C, S, S, Sattar, N, Schiborn, C, Schmidt, B, Schöttker, B, Schulze, M, Schwartz, J, Selmer, R, Shea, S, Shipley, M, Sieri, S, Söderberg, S, Sofat, R, Tamosiunas, A, Thorand, B, Tillmann, T, Tjønneland, A, Tong, T, Trichopoulou, A, Tumino, R, Tunstall-Pedoe, H, Tybjaerg-Hansen, A, Tzoulaki, J, van der Heijden, A, van der Schouw, Y, Verschuren, W, Völzke, H, Waldeyer, C, Wareham, N, Weiderpass, E, Weidinger, F, Wild, P, Willeit, J, Willeit, P, Wilsgaard, T, Woodward, M, Zeller, T, Zhang, D, Zhou, B, Bakker, SJL, Da Providencia Costa, RB, Beulens, JWJ, Boer, JMA, Boutron-Ruault, MC, Brunner, EJ, Butterworth, AS, Cook, NR, Dahm, CC, Gansevoort, RT, Gillum, RF, Hansson, PO, Ikram, MK, Kronmal, RA, Pablos, DL, Malyutina, So, Ibañez, AM, Mathiesen, EB, Meade, TW, Meyer, HE, Moons, KGM, Nordestgaard, BG, Psaty, BM, Garcia, JRQ, Ridker, PM, C Sans, Schwartz, JE, Selmer, RM, Shipley, MJ, Tong, TYN, van der Schouw, YT, Verschuren, WMM, Wareham, NJ, Achenbach, S, Aleksandrova, K, Amiano, P, San Sebastian, D, Amouyel, P, Andersson, J, Bakker, S, Da Providencia Costa, R, Beulens, J, Blaha, M, Bobak, M, Boer, J, Bonet, C, Bonnet, F, Boutron-Ruault, M, Braaten, T, Brenner, H, Brunner, F, Brunner, E, Brunström, M, Buring, J, Butterworth, A, Capkova, N, Cesana, G, Chrysohoou, C, Colorado-Yohar, S, Cook, N, Cooper, C, Dahm, C, Davidson, K, Dennison, E, Di Castelnuovo, A, Donfrancesco, C, Dörr, M, Doryńska, A, Eliasson, M, Engström, G, Ferrari, P, Ferrario, M, Ford, I, Fu, M, Gansevoort, R, Giampaoli, S, Gillum, R, Gómez de la Cámara, A, Grassi, G, Hansson, P, Huculeci, R, Hveem, K, Iacoviello, L, Ikram, M, Jørgensen, T, Joseph, B, Jousilahti, P, Wouter Jukema, J, Kaaks, R, Katzke, V, Kavousi, M, Kiechl, S, Klotsche, J, König, W, Kronmal, R, Kubinova, R, Kucharska-Newton, A, Läll, K, Lehmann, N, Leistner, D, Linneberg, A, Pablos, D, Lorenz, T, Lu, W, Luksiene, D, Lyngbakken, M, Magnussen, C, Malyutina, S, Ibañez, A, Masala, G, Mathiesen, E, Matsushita, K, Meade, T, Melander, O, Meyer, H, Moons, K, Moreno-Iribas, C, Muller, D, Münzel, T, Nikitin, Y, Nordestgaard, B, Omland, T, Onland, C, Overvad, K, Packard, C, Pająk, A, Palmieri, L, Panagiotakos, D, Panico, S, Perez-Cornago, A, Peters, A, Pietilä, A, Pikhart, H, Psaty, B, Quarti-Trevano, F, Garcia, J, Riboli, E, Ridker, P, Rodriguez, B, Rodriguez-Barranco, M, Rosengren, A, Roussel, R, Sacerdote, C, S, S, Sattar, N, Schiborn, C, Schmidt, B, Schöttker, B, Schulze, M, Schwartz, J, Selmer, R, Shea, S, Shipley, M, Sieri, S, Söderberg, S, Sofat, R, Tamosiunas, A, Thorand, B, Tillmann, T, Tjønneland, A, Tong, T, Trichopoulou, A, Tumino, R, Tunstall-Pedoe, H, Tybjaerg-Hansen, A, Tzoulaki, J, van der Heijden, A, van der Schouw, Y, Verschuren, W, Völzke, H, Waldeyer, C, Wareham, N, Weiderpass, E, Weidinger, F, Wild, P, Willeit, J, Willeit, P, Wilsgaard, T, Woodward, M, Zeller, T, Zhang, D, Zhou, B, Bakker, SJL, Da Providencia Costa, RB, Beulens, JWJ, Boer, JMA, Boutron-Ruault, MC, Brunner, EJ, Butterworth, AS, Cook, NR, Dahm, CC, Gansevoort, RT, Gillum, RF, Hansson, PO, Ikram, MK, Kronmal, RA, Pablos, DL, Malyutina, So, Ibañez, AM, Mathiesen, EB, Meade, TW, Meyer, HE, Moons, KGM, Nordestgaard, BG, Psaty, BM, Garcia, JRQ, Ridker, PM, C Sans, Schwartz, JE, Selmer, RM, Shipley, MJ, Tong, TYN, van der Schouw, YT, Verschuren, WMM, and Wareham, NJ
Abstract: Aims: The aim of this study was to develop, validate, and illustrate an updated prediction model (SCORE2) to estimate 10-year fatal and non-fatal cardiovascular disease (CVD) risk in individuals without previous CVD or diabetes aged 40-69 years in Europe. Methods and results : We derived risk prediction models using individual-participant data from 45 cohorts in 13 countries (677 684 individuals, 30 121 CVD events). We used sex-specific and competing risk-adjusted models, including age, smoking status, systolic blood pressure, and total- and HDL-cholesterol. We defined four risk regions in Europe according to country-specific CVD mortality, recalibrating models to each region using expected incidences and risk factor distributions. Region-specific incidence was estimated using CVD mortality and incidence data on 10 776 466 individuals. For external validation, we analysed data from 25 additional cohorts in 15 European countries (1 133 181 individuals, 43 492 CVD events). After applying the derived risk prediction models to external validation cohorts, C-indices ranged from 0.67 (0.65-0.68) to 0.81 (0.76-0.86). Predicted CVD risk varied several-fold across European regions. For example, the estimated 10-year CVD risk for a 50-year-old smoker, with a systolic blood pressure of 140 mmHg, total cholesterol of 5.5 mmol/L, and HDL-cholesterol of 1.3 mmol/L, ranged from 5.9% for men in low-risk countries to 14.0% for men in very high-risk countries, and from 4.2% for women in low-risk countries to 13.7% for women in very high-risk countries. Conclusion : SCORE2-a new algorithm derived, calibrated, and validated to predict 10-year risk of first-onset CVD in European populations-enhances the identification of individuals at higher risk of developing CVD across Europe.
Published: 2021

5. Hemochromatosis (HFE) gene mutations and risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.

Author: Ciències Mèdiques Bàsiques, Universitat Rovira i Virgili, Agudo A, Bonet C, Sala N, Muñoz X, Aranda N, Fonseca-Nunes A, Clavel-Chapelon F, Boutron-Ruault MC, Vineis P, Panico S, Palli D, Tumino R, Grioni S, Quirós JR, Molina E, Navarro C, Barricarte A, Chamosa S, Allen NE, Khaw KT, Bueno-de-Mesquita HB, Siersema PD, Numans ME, Trichopoulou A, Lagiou P, Trichopoulos D, Kaaks R, Canzian F, Boeing H, Meidtner K, Johansson M, Sund M, Manjer J, Overvad K, Tjonneland A, Lund E, Weiderpass E, Jenab M, Fedirko V, Offerhaus GJ, Riboli E, González CA, Jakszyn P, Ciències Mèdiques Bàsiques, Universitat Rovira i Virgili, and Agudo A, Bonet C, Sala N, Muñoz X, Aranda N, Fonseca-Nunes A, Clavel-Chapelon F, Boutron-Ruault MC, Vineis P, Panico S, Palli D, Tumino R, Grioni S, Quirós JR, Molina E, Navarro C, Barricarte A, Chamosa S, Allen NE, Khaw KT, Bueno-de-Mesquita HB, Siersema PD, Numans ME, Trichopoulou A, Lagiou P, Trichopoulos D, Kaaks R, Canzian F, Boeing H, Meidtner K, Johansson M, Sund M, Manjer J, Overvad K, Tjonneland A, Lund E, Weiderpass E, Jenab M, Fedirko V, Offerhaus GJ, Riboli E, González CA, Jakszyn P
Abstract: Hereditary hemochromatosis (HH) is a strong risk factor for hepatocellular cancer, and mutations in the HFE gene associated with HH and iron overload may be related to other tumors, but no studies have been reported for gastric cancer (GC). A nested case-control study was conducted within the European Prospective Investigation into Cancer and Nutrition (EPIC), including 365 incident gastric adenocarcinoma and 1284 controls matched by center, sex, age and date of blood collection. Genotype analysis was performed for two functional polymorphisms (C282Y/rs1800562 and H63D/rs1799945) and seven tagSNPs of the HFE genomic region. Association with all gastric adenocarcinoma, and according to anatomical localization and histological subtype, was assessed by means of the odds ratio (OR) and 95% confidence interval (CI) estimated by unconditional logistic regression adjusted for the matching variables. We observed a significant association for H63D with OR (per rare allele) of 1.32 (CI = 1.03-1.69). In subgroup analyses, the association was stronger for non-cardia anatomical subsite (OR = 1.60, CI = 1.16-2.21) and intestinal histological subtype (OR = 1.82, CI = 1.27-2.62). Among intestinal cases, two tagSNPs (rs1572982 and rs6918586) also showed a significant association that disappeared after adjustment for H63D. No association with tumors located in the cardia or with diffuse subtype was found for any of the nine SNPs analyzed. Our results suggest that H63D variant in HFE gene seems to be associated with GC risk of the non-cardia region and intestinal type, possibly due to its association with iron overload although a role for other mechanisms cannot be entirely ruled out.
Published: 2019

6. Association of CRP genetic variants with blood concentrations of C-reactive protein and colorectal cancer risk

Author: Nimptsch, K, Aleksandrova, K, Boeing, H, Janke, J, Lee, YA, Jenab, M, Bueno-de-Mesquita, HB, Jansen, EH, Tsilidis, KK, Trichopoulou, A, Weiderpass, E, Wu, C, Overvad, K, Tjønneland, A, Boutron-Ruault, MC, Dossus, L, Racine, A, Kaaks, R, Canzian, F, Lagiou, P, Trichopoulos, D, Palli, D, Agnoli, C, Tumino, R, Vineis, P, Panico, S, Johansson, A, Van Guelpen, B, Khaw, KT, Wareham, N, Peeters, PH, Quirós, JR, Venceslá García, A, Molina-Montes, E, Dorronsoro, M, Chirlaque, MD, Barricarte Gurrea, A, Key, TJ, Duarte-Salles, T, Stepien, M, Gunter, MJ, Riboli, E, Pischon, T, Nimptsch, K, Aleksandrova, K, Boeing, H, Janke, J, Lee, Ya, Jenab, M, Bueno De Mesquita, Bh, Jansen, Eh, Tsilidis, Kk, Trichopoulou, A, Weiderpass, E, Wu, C, Overvad, K, Tj?nneland, A, Boutron Ruault, Mc, Dossus, L, Racine, A, Kaaks, R, Canzian, F, Lagiou, P, Trichopoulos, D, Palli, D, Agnoli, C, Tumino, R, Vineis, P, Panico, Salvatore, Johansson, A, Van Guelpen, B, Khaw, Kt, Wareham, N, Peeters, Ph, Quir?s, Jr, Vencesl? Garc?a, A, Molina Montes, E, Dorronsoro, M, Chirlaque, Md, Barricarte Gurrea, A, Key, Tj, Duarte Salles, T, Stepien, M, Gunter, Mj, Riboli, E, and Pischon, T.
Subjects: Adult, Male, Genotype, colorectal cancer, INFLAMMATORY MARKERS, Polymorphism, Single Nucleotide, Article, C-reactive protein, Risk Factors, COLON, Biomarkers, Tumor, Journal Article, Humans, COHORT, Comparative Study, Prospective Studies, Aged, CRP genetic variants, Research Support, Non-U.S. Gov't, WOMEN, Middle Aged, Prognosis, Cardiovascular and Metabolic Diseases, Case-Control Studies, Randomized Controlled Trial, MENDELIAN RANDOMIZATION, POPULATIONS, Female, NUTRITION, HEALTH, Colorectal Neoplasms, Follow-Up Studies
Abstract: High blood concentrations of C-reactive protein (CRP) have been associated with elevated risk of colorectal cancer in several prospective studies including the European Prospective Investigation into Cancer and Nutrition (EPIC), but it is unknown whether these observations reflect a causal relationship. We aimed to investigate whether CRP genetic variants associated with lifelong higher CRP concentrations translate into higher colorectal cancer risk. We conducted a prospective nested case-control study within EPIC including 727 cases diagnosed between 1992 and 2003 and 727 matched controls selected according to an incidence-density sampling protocol. Baseline CRP concentrations were measured in plasma samples by a high sensitivity assay. Tagging single nucleotide polymorphisms (SNPs) in the CRP gene (rs1205, rs1800947, rs1130864, rs2808630, rs3093077) were identified via HapMap. The causal effect of CRP on colorectal cancer risk was examined in a Mendelian Randomization approach utilizing multiple CRP genetic variants as instrumental variables. The SNPs rs1205, rs1800947, rs1130864 and rs3093077 were significantly associated with CRP concentrations and were incorporated in a CRP allele score which was associated with 13% higher CRP concentrations per allele count (95% confidence interval 8%, 19%). Using the CRP-score as instrumental variable, genetically 2-fold higher CRP concentrations were associated with higher risk of colorectal cancer (odds ratio 1.74, 95% confidence interval 1.06, 2.85). Similar observations were made using alternative definitions of instrumental variables. Our findings give support to the hypothesis that elevated circulating CRP may play a direct role in the etiology of colorectal cancer.
Published: 2016

7. Consumptiion of fruits,vegetables, and fruit juices and differentiated thyroid carcinoma risk in the European Investigation into Cancer and Nutrition (EPIC) study

Author: Zamora-Ros, R, Beraud, V, Franceschi, S, Cayssials, V, Tsilidis, KK, Boutron-Ruault, MC, Weiderpass, E, Overvad, K, Tjonneland, A, Eriksen, AK, Bonnet, F, Affret, A, Katzke, V, Kuhn, T, Boeing, H, Trichopoulou, A, Valanou, E, Karakatsani, A, Masala, G, Grioni, S, Santucci de Magistris, M, Tumino, R, Ricceri, F, Skeie, G, Parr, CL, Merino, S, Salamanca-Fernandez, E, Chirlaque, MD, Ardanaz, E, Amiano, P, Almquist, M, Drake, I, Hennings, J, Sandstrom, M, Bueno-de-Mesquita, HB, Peeters, PH, Khaw, KT, Wareham, NJ, Schmidt, JA, Perez-Cornago, A, Aune, D, Riboli, E, Slimani, N, Scalbert, A, Romieu, I, Agudo, A, Rinaldi, S, and Imperial College Trust
Subjects: vegetables, Adult, Male, Healthy Diet, fruits, Middle Aged, fruit juices, Diet, Cohort Studies, Europe, Fruit and Vegetable Juices, Fruit, thyroid cancer, Humans, Female, Prospective Studies, Thyroid Neoplasms, Oncology & Carcinogenesis, EPIC, intake, 1112 Oncology And Carcinogenesis, Aged
Abstract: Fruit and vegetable (F&V) intake is considered as probably protective against overall cancer risk, but results in previous studies are not consistent for thyroid cancer (TC). The purpose of this study is to examine the association between the consumption of fruits, vegetables, fruit juices and differentiated thyroid cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The EPIC study is a cohort including over half a million participants, recruited between 1991 and 2000. During a mean follow-up of 14 years, 748 incident first primary differentiated TC cases were identified. F&V and fruit juice intakes were assessed through validated country-specific dietary questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox regression models adjusted for potential confounding factors. Comparing the highest versus lowest quartile of intake, differentiated TC risk was not associated with intakes of total F&V (HR: 0.89; 95% CI: 0.68–1.15; p-trend = 0.44), vegetables (HR: 0.89; 95% CI: 0.69–1.14; p-trend = 0.56), or fruit (HR: 1.00; 95% CI: 0.79–1.26; p-trend = 0.64). No significant association was observed with any individual type of vegetable or fruit. However, there was a positive borderline trend with fruit juice intake (HR: 1.23; 95% CI: 0.98–1.53; p-trend = 0.06). This study did not find any significant association between F&V intakes and differentiated TC risk; however a positive trend with fruit juice intake was observed, possibly related to its high sugar content.
Published: 2017

8. Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148

Author: Fang, J, Jia, J, Makowski, M, Xu, M, Wang, Z, Zhang, T, Hoskins, Jw, Choi, J, Han, Y, Zhang, M, Thomas, J, Kovacs, M, Collins, I, Dzyadyk, M, Thompson, A, O'Neill, M, Das, S, Lan, Q, Koster, R, Solomon, Rs, Kraft, P, Wolpin, Bm, Jansen, Pwtc, Olson, S, Mcglynn, Ka, Kanetsky, Pa, Chatterjee, N, Barrett, Jh, Dunning, Am, Taylor, Jc, Newton Bishop, Ja, Bishop, Dt, Andresson, T, Petersen, Gm, Amos, Ci, Iles, Mm, Nathanson, Kl, Landi, Mt, Vermeulen, M, Brown, Km, Amundadottir, Lt, Canzian, F, Kooperberg, C, Arslan, Aa, Bracci, Pm, Buring, J, Duell, Ej, Gallinger, S, Jacobs, Ej, Kamineni, A, Van Den Eeden, S, Klein, Ap, Kolonel, Ln, Li, D, Olson, Sh, Risch, Ha, Sesso, Hd, Visvanathan, K, Zheng, W, Albanes, D, Austin, Ma, Boutron Ruault, Mc, Bueno de Mesquita, Hb, Cotterchio, M, Gaziano, Jm, Giovannucci, El, Goggins, M, Gross, M, Hassan, M, Helzlsouer, Kj, Holly, Ea, Hunter, Dj, Jenab, M, Kaaks, R, Key, Tj, Khaw, Kt, Krogh, V, Kurtz, Rc, Lacroix, A, Le Marchand, L, Mannisto, S, Patel, Av, Peeters, Phm, Riboli, E, Shu, Xo, Sund, M, Thornquist, M, Tjønneland, A, Tobias, Gs, Trichopoulos, D, Wactawski Wende, J, Yu, H, Yu, K, Zeleniuch Jacquotte, A, Hoover, R, Hartge, P, Fuchs, C, Chanock, Sj, Stevens, V, Caporaso, Ne, Brennan, P, Mckay, J, Wu, X, Hung, Rj, Mclaughlin, Jr, Bickeboller, H, Risch, A, Wichmann, E, Houlston, R, Mann, G, Hopper, J, Aitken, J, Armstrong, B, Giles, G, Holland, E, Kefford, R, Cust, A, Jenkins, M, Schmid, H, Puig, S, Aguilera, P, Badenas, C, Barreiro, A, Carrera, C, Gabriel, D, Xavier, Pg, Iglesias Garcia, P, Malvehy, J, Mila, M, Pigem, R, Potrony, M, Batille, Ja, Marti, Gt, Hayward, N, Martin, N, Montgomery, G, Duffy, D, Whiteman, D, Gregor, Sm, Calista, D, Landi, G, Minghetti, P, Arcangeli, F, Bertazzi, Pa, Ghiorzo, Paola, Bianchi, Giovanna, Pastorino, Lorenza, Bruno, William, Andreotti, Virginia, Queirolo, P, Spagnolo, Francesco, Mackie, R, Lang, J, Gruis, N, van Nieuwpoort, Fa, Out, C, Bergman, W, Kukutsch, N, Bavinck, Jnb, Bakker, B, van der Stoep, N, Ter Huurne, J, van der Rhee, H, Bekkenk, M, Snels, D, van Praag, M, Brochez, L, Gerritsen, R, Crijns, M, Vasen, H, Janssen, B, Ingvar, C, Olsson, H, Jonsson, G, Borg, A, Harbst, K, Nielsen, K, Zander, As, Molvern, A, Helsing, P, Andresen, Pa, Rootwelt, H, Akslen, La, Bressac de Paillerets, B, Demenais, F, Avril, Mf, Chaudru, V, Jeannin, P, Lesueur, F, Maubec, E, Mohamdi, H, Bossard, M, Vaysse, A, Boitier, F, Caron, O, Caux, F, Dalle, S, Dereure, O, Leroux, D, Martin, L, Mateus, C, Robert, C, Stoppa Lyonnet, D, Thomas, L, Wierzbicka, E, Elder, D, Ming, M, Mitra, N, Debniak, T, Lubinski, J, Hocevar, M, Novakovic, S, Peric, B, Skerl, P, Hansson, J, Hoiom, V, Freidman, E, Azizi, E, Baron Epel, O, Scope, A, Pavlotsky, F, Cohen Manheim, I, Laitman, Y, Harland, M, Randerson Moor, J, Laye, J, Davies, J, Nsengimana, J, O'Shea, S, Chan, M, Gascoyne, J, Tucker, Ma, Goldstein, Am, and Yang, X. r.
Subjects: 0301 basic medicine, Male, Lung Neoplasms, Skin Neoplasms, General Physics and Astronomy, Genome-wide association study, VARIANTS, Histones, Skin cancer, RNA, Small Interfering, Melanoma, Telomerase, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), Pancreas cancer, Regulation of gene expression, Genetics, Zinc finger, Gene knockdown, Multidisciplinary, Proteomics and Chromatin Biology, TRICL Consortium, Chromosome Mapping, GenoMEL Consortium, PANCREATIC-CANCER, Multidisciplinary Sciences, DNA-Binding Proteins, Gene Expression Regulation, Neoplastic, Science & Technology - Other Topics, Chromosomes, Human, Pair 5, Female, Lung cancer, Signal Transduction, SUSCEPTIBILITY LOCI, Science, Locus (genetics), Single-nucleotide polymorphism, PROMOTES GROWTH, Biology, Polymorphism, Single Nucleotide, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, LUNG-CANCER, Testicular Neoplasms, Cell Line, Tumor, MD Multidisciplinary, Humans, Genetic Predisposition to Disease, QUANTITATIVE PROTEOMICS, GENOME-WIDE ASSOCIATION, Gene, PanScan Consortium, Càncer de pell, Càncer de pàncrees, Alleles, Science & Technology, Kirurgi, HUMAN-CELLS, Telomere Homeostasis, Correction, General Chemistry, Molecular biology, TERT-CLPTM1L LOCUS, Telomere, Pancreatic Neoplasms, 030104 developmental biology, Genetic Loci, TELOMERE LENGTH, Càncer de pulmó, Surgery, Genètica, Genome-Wide Association Study, Transcription Factors
Abstract: Genome wide association studies (GWAS) have mapped multiple independent cancer susceptibility loci to chr5p15.33. Here, we show that fine-mapping of pancreatic and testicular cancer GWAS within one of these loci (Region 2 in CLPTM1L) focuses the signal to nine highly correlated SNPs. Of these, rs36115365-C associated with increased pancreatic and testicular but decreased lung cancer and melanoma risk, and exhibited preferred protein-binding and enhanced regulatory activity. Transcriptional gene silencing of this regulatory element repressed TERT expression in an allele-specific manner. Proteomic analysis identifies allele-preferred binding of Zinc finger protein 148 (ZNF148) to rs36115365-C, further supported by binding of purified recombinant ZNF148. Knockdown of ZNF148 results in reduced TERT expression, telomerase activity and telomere length. Our results indicate that the association with chr5p15.33-Region 2 may be explained by rs36115365, a variant influencing TERT expression via ZNF148 in a manner consistent with elevated TERT in carriers of the C allele., Genetic variants at multiple loci of chr5p15.33 have been associated with susceptibility to numerous cancers. Here the authors show that the association of one of these loci may be explained by a variant, rs36115365, influencing telomerase reverse transcriptase (TERT) expression via ZNF148.
Published: 2017

9. Tea and coffee consumption and risk of esophageal cancer: the European prospective investigation into cancer and nutrition study

Author: Zamora Ros R, Luj?n Barroso L, Bueno de Mesquita HB, Dik VK, Boeing H, Steffen A, Tj?nneland A, Olsen A, Bech BH, Overvad K, Boutron Ruault MC, Racine A, Fagherazzi G, Kuhn T, Katzke V, Trichopoulou A, Lagiou P, Trichopoulos D, Tumino R, Vineis P, Grioni S, Palli D, Weiderpass E, Skeie G, Huerta JM, S?nchez MJ, Arg?elles M, Amiano P, Ardanaz E, Nilsson L, Wallner B, Lindkvist B, Wallstr?m P, Peeters PH, Key TJ, Khaw KT, Wareham NJ, Freisling H, Stepien M, Ferrari P, Gunter MJ, Murphy N, Riboli E, Gonz?lez CA, PANICO, SALVATORE, Zamora Ros, R, Luj?n Barroso, L, Bueno de Mesquita, Hb, Dik, Vk, Boeing, H, Steffen, A, Tj?nneland, A, Olsen, A, Bech, Bh, Overvad, K, Boutron Ruault, Mc, Racine, A, Fagherazzi, G, Kuhn, T, Katzke, V, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Tumino, R, Panico, Salvatore, Vineis, P, Grioni, S, Palli, D, Weiderpass, E, Skeie, G, Huerta, Jm, S?nchez, Mj, Arg?elles, M, Amiano, P, Ardanaz, E, Nilsson, L, Wallner, B, Lindkvist, B, Wallstr?m, P, Peeters, Ph, Key, Tj, Khaw, Kt, Wareham, Nj, Freisling, H, Stepien, M, Ferrari, P, Gunter, Mj, Murphy, N, Riboli, E, and Gonz?lez, Ca
Subjects: Cohort Studies, Europe, Male, Risk, Esophageal Neoplasms, Tea, Smoking, Humans, Female, Prospective Studies, Middle Aged, Coffee
Abstract: Epidemiological data regarding tea and coffee consumption and risk of esophageal cancer (EC) is still inconclusive. We examined the association of tea and coffee consumption with EC risk among 442,143 men and women without cancer at baseline from 9 countries of the European Prospective Investigation into Cancer and Nutrition. Tea and coffee intakes were recorded using country-specific validated dietary questionnaires. Cox regression models were used to analyze the relationships between tea and coffee intake and EC risk. During a mean follow-up of 11.1 years, 339 participants developed EC, of which 142 were esophageal adenocarcinoma (EAC) and 174 were esophageal squamous cell carcinoma (ESCC). In the multivariable models, no significant associations between tea (mostly black tea), and coffee intake and risk of EC, EAC and ESCC were observed. In stratified analyses, among men coffee consumption was inversely related to ESCC (HR for comparison of extreme tertiles 0.42, 95% CI 0.20-0.88; p-trend=0.022), but not among women. In current smokers, a significant and inverse association was observed between ESCC risk and tea (HR 0.46, 95% CI 0.23-0.93; p-trend=0.053) and coffee consumption (HR 0.37, 95% CI 0.19-0.73; p-trend=0.011). However, no statistically significant findings were observed using the continuous variable (per 100 mL/d). These data did not show a significant association between tea and coffee consumption and EC, EAC and ESCC, although a decreased risk of ESCC among men and current smokers is suggested, but need to be confirmed in further prospective studies including more cases. What's new? Tea and coffee, because of their high polyphenol content, may help reduce the risk of esophageal cancer (EC), but data across multiple studies have been inconsistent. In this cohort study of men and women from nine European countries, no significant association was found between coffee and tea consumption and overall risk of EC and its subtypes. Among current smokers or men, an inverse association with esophageal squamous cell carcinoma was suggested, although further prospective studies are needed to confirm the potential relationship. © 2014 UICC.
Published: 2014

10. Endometrial cancer risk prediction including serum-based biomarkers: Results from the EPIC cohort

Author: Fortner, RT, Hüsing, A, Kühn, T, Konar, M, Overvad, K, Tjønneland, A, Hansen, L, Boutron-Ruault, MC, Severi, G, Fournier, A, Boeing, H, Trichopoulou, A, Benetou, V, Orfanos, P, Masala, G, Agnoli, C, Mattiello, A, Tumino, R, Sacerdote, C, Bueno-de-Mesquita, HB, Peeters, PH, Weiderpass, E, Gram, IT, Gavrilyuk, O, Quirós, JR, Huerta, JM, Ardanaz, E, Larrañaga, N, Lujan-Barroso, L, Sánchez-Cantalejo, E, Butt, ST, Borgquist, S, Idahl, A, Lundin, E, Khaw, KT, Allen, Naomi, Rinaldi, S, Dossus, L, Gunter, M, Merritt, MA, Tzoulaki, I, Riboli, E, Kaaks, R, University Medical Center Utrecht, Imperial College Trust, and Biyoistatistik
Subjects: Adult, Blood Glucose, Risk, Cancer Research, EUROPE, prospective cohort, Comorbidity, Risk Assessment, lipids, risk prediction, MARKERS, metabolic markers, Surveys and Questionnaires, growth factors, Journal Article, Biomarkers, Tumor, Humans, sex steroids, Single-Blind Method, Oncology & Carcinogenesis, adipokines, Aged, Metabolic Syndrome, Medicine(all), Inflammation, Science & Technology, Incidence, Metabolic Syndrome X, Blood Proteins, Middle Aged, inflammatory markers, cytokines, Hormones, Endometrial Neoplasms, Europe, Multicenter Study, Oncology, POSTMENOPAUSAL WOMEN, Case-Control Studies, endometrial cancer, NUTRITION, Female, Life Sciences & Biomedicine, 1112 Oncology And Carcinogenesis, Follow-Up Studies
Abstract: Endometrial cancer risk prediction models including lifestyle, anthropometric and reproductive factors have limited discrimina-tion. Adding biomarker data to these models may improve predictive capacity; to our knowledge, this has not been investigat-ed for endometrial cancer. Using a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, we investigated the improvement in discrimination gained by adding serum biomarker concentrations to risk estimates derived from an existing risk prediction model based on epidemiologic factors. Serum concentrations of sex steroid hormones, metabolic markers, growth factors, adipokines and cytokines were evaluated in a step-wise backward selec-tion process; biomarkers were retained at p < 0.157 indicating improvement in the Akaike information criterion (AIC). Improvement in discrimination was assessed using the C-statistic for all biomarkers alone, and change in C-statistic from addition of biomarkers to preexisting absolute risk estimates. We used internal validation with bootstrapping (1000-fold) to adjust for over-fitting. Adiponectin, estrone, interleukin-1 receptor antagonist, tumor necrosis factor-alpha and triglycerides were select-ed into the model. After accounting for over-fitting, discrimination was improved by 2.0 percentage points when all evaluated biomarkers were included and 1.7 percentage points in the model including the selected biomarkers. Models including eti-ologic markers on independent pathways and genetic markers may further improve discrimination.
Published: 2016

11. Biomarkers of folate and vitamin B12, alcohol intake and breast cancer risk: report from the EPIC cohort

Author: Matejcic, M, Ricci, C, Perrier, F, Huybrechts, I, Buckland, G, Amiano, P, Zeleniuch-Jacquotte, A, Gylling, B, Sieri, S, Key, T, van Gils, CH, Peeters, PH, Trichopoulou, A, Lagiou, P, Benetou, V, Sánchez, MJ, His, M, Barricarte, A, Skeie, G, Weiderpass, E, Kaaks, R, Fortner, R, Chirlaque, MD, Cox, DG, Palli, D, Boutron-Ruault, MC, Cadeau, C, Bueno-de-Mesquita, HB, Ricceri, F, Quirós, JR, Tumino, R, Riboli, E, Romieu, I, and Chajès, V
Abstract: Background. B vitamin status and their interaction with alcohol were suggested to play a role in breast carcinogenesis; however, results from epidemiological studies have been inconsistent. We investigated the association between biomarkers of folate and vitamin B12 and the risk of breast cancer (BC) in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods. Microbiological assays were used to determine plasma concentrations of folate and vitamin B12 in 2,491 BC cases individually matched to 2,521 controls among women participants to the EPIC study who provided baseline blood samples. Multivariable conditional logistic regression models were used to estimate odds ratios by quartiles of plasma B vitamins. Subgroup analyses by menopausal status, hormone receptor status of breast tumors (ER, PR, and HER2), levels of alcohol intake, and MTHFR polymorphisms (677C>T and 1298A>C) were also performed. Results. Plasma concentrations of folate and vitamin B12 were not significantly associated with the overall risk of BC. No significant association emerged by hormone receptor status. A borderline positive association was observed between plasma concentrations of vitamin B12 and BC risk in women consuming above the median level of alcohol (ORQ4-Q1 = 1.30; 95% CI 1.03-1.64; Ptrend = 0.051). Plasma concentrations of vitamin B12 were also marginally associated with BC risk in women with plasma folate levels below the median value (ORQ4-Q1 = 1.26; 95% CI 1.00–1.60; Ptrend = 0.014). However, no significant heterogeneity between subgroups of alcohol intake (Pheterogeneity = 0.14) and plasma folate (Pheterogeneity = 0.059) was found. The association between MTHFR polymorphisms and BC risk in a subsample of this study population was not statistically significant. Conclusions. The present study raises the possibility for a role of vitamin B12 in the etiology of BC, and provides support for potential interactions between nutrients involved in one-carbon metabolism.
Published: 2016

12. Polymorphisms of Helicobacter pylori signaling pathway genes and gastric cancer risk in the European prospective investigation into cancer-eurgast cohort

Author: Companioni O, Bonet C, Mu?oz X, Weiderpass E, Tumino R, Palli D, Agnoli C, Vineis P, Boutron Ruault MC, Racine A, Clavel Chapelon F, Travis RC, Khaw KT, Riboli E, Murphy N, Vergnaud AC, Trichopoulou A, Benetou V, Trichopoulos D, Lund E, Johansen D, Lindkvist B, Johansson M, Sund M, Ardanaz E, S?nchez Cantalejo E, Huerta JM, Dorronsoro M, Ram?n Quir?s J, Tjonneland A, Mortensen LM, Overvad K, Chang Claude J, Rizzato C, Boeing H, de Mesquita HB, Siersema P, Peeters PH, Numans ME, Carneiro F, Licaj I, Freisling H, Sala N, Gonz?lez CA, PANICO, SALVATORE, Companioni, O, Bonet, C, Mu?oz, X, Weiderpass, E, Panico, Salvatore, Tumino, R, Palli, D, Agnoli, C, Vineis, P, Boutron Ruault, Mc, Racine, A, Clavel Chapelon, F, Travis, Rc, Khaw, Kt, Riboli, E, Murphy, N, Vergnaud, Ac, Trichopoulou, A, Benetou, V, Trichopoulos, D, Lund, E, Johansen, D, Lindkvist, B, Johansson, M, Sund, M, Ardanaz, E, S?nchez Cantalejo, E, Huerta, Jm, Dorronsoro, M, Ram?n Quir?s, J, Tjonneland, A, Mortensen, Lm, Overvad, K, Chang Claude, J, Rizzato, C, Boeing, H, de Mesquita, Hb, Siersema, P, Peeters, Ph, Numans, Me, Carneiro, F, Licaj, I, Freisling, H, Sala, N, and Gonz?lez, Ca
Subjects: digestive system diseases
Abstract: Helicobacter pylori is a recognized causal factor of noncardia gastric cancer (GC). Lipopolysaccharide and peptidoglycan of this bacterium are recognized by CD14, TLR4 and NOD2 human proteins, while NFKB1 activates the transcription of pro-inflammatory cytokines to elicit an immune response. Single nucleotide polymorphisms (SNPs) in these genes have been associated with GC in different populations. We genotyped 30 SNPs of these genes, in 365 gastric adenocarcinomas and 1,284 matched controls from the European Prospective Investigation into Cancer cohort. The association with GC and its histological and anatomical subtypes was analyzed by logistic regression and corrected for multiple comparisons. Using a log-additive model, we found a significant association between SNPs in CD14, NOD2 and TLR4 with GC risk. However, after applying the multiple comparisons tests only the NOD2 region remained significant (p = 0.009). Analysis according to anatomical subtypes revealed NOD2 and NFKB1 SNPs associated with noncardia GC and CD14 SNPs associated with cardia GC, while analysis according to histological subtypes showed that CD14 was associated with intestinal but not diffuse GC. The multiple comparisons tests confirmed the association of NOD2 with noncardia GC (p = 0.0003) and CD14 with cardia GC (p = 0.01). Haplotype analysis was in agreement with single SNP results for NOD2 and CD14 genes. From these results, we conclude that genetic variation in NOD2 associates with noncardia GC while variation in CD14 is associated with cardia GC.
Published: 2014

13. OP0253 Passive smoking in childhood and history of chronic diarrhea increases the risk of developing rheumatoid arthritis (RA)

Author: Seror, R, primary, Gusto, G, additional, Boutron-Ruault, MC, additional, and Mariette, X, additional
Published: 2017
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14. Abdominal obesity, weight gain during adulthood and risk of liver and biliary tract cancer in a European cohort

Author: Schlesinger, S, Aleksandrova, K, Pischon, T, Fedirko, V, Jenab, M, Trepo, E, Boffetta, P, Dahm, CC, Overvad, K, Tjønneland, A, Halkjær, J, Fagherazzi, G, Boutron-Ruault, MC, Carbonnel, F, Kaaks, R, Lukanova, A, Boeing, H, Trichopoulou, A, Bamia, C, Lagiou, P, Palli, D, Grioni, S, Panico, S, Tumino, R, Vineis, P, Hb, BDM, Van Den Berg, S, Peeters, PHM, Braaten, T, Weiderpass, E, Quirós, JR, Travier, N, Sánchez, MJ, Navarro, C, Barricarte, A, Dorronsoro, M, Lindkvist, B, Regner, S, Werner, M, Sund, M, Khaw, KT, Wareham, N, Travis, RC, Norat, T, Wark, PA, Riboli, E, Nöthlings, U, Schlesinger, S, Aleksandrova, K, Pischon, T, Fedirko, V, Jenab, M, Trepo, E, Boffetta, P, Dahm, Cc, Overvad, K, Tj?nneland, A, Halkj?r, J, Fagherazzi, G, Boutron Ruault, Mc, Carbonnel, F, Kaaks, R, Lukanova, A, Boeing, H, Trichopoulou, A, Bamia, C, Lagiou, P, Palli, D, Grioni, S, Panico, Salvatore, Tumino, R, Vineis, P, Bueno de Mesquita, Hb, van den Berg, S, Peeters, Ph, Braaten, T, Weiderpass, E, Quir?s, Jr, Travier, N, S?nchez, Mj, Navarro, C, Barricarte, A, Dorronsoro, M, Lindkvist, B, Regner, S, Werner, M, Sund, M, Khaw, Kt, Wareham, N, Travis, Rc, Norat, T, Wark, Pa, Riboli, E, N?thlings, U., Schlesinger, S., Aleksandrova, K., Pischon, T., Fedirko, V., Jenab, M., Trepo, E., Boffetta, P., Dahm, C.C., Overvad, K., Tjønneland, A., Halkjær, J., Fagherazzi, G., Boutron-Ruault, M.-C., Carbonnel, F., Kaaks, R., Lukanova, A., Boeing, H., Trichopoulou, A., Bamia, C., Lagiou, P., Palli, D., Grioni, S., Panico, S., Tumino, R., Vineis, P., Hb, B.-D.-M., Van Den Berg, S., Peeters, P.H.M., Braaten, T., Weiderpass, E., Quirós, J.R., Travier, N., Sánchez, M.-J., Navarro, C., Barricarte, A., Dorronsoro, M., Lindkvist, B., Regner, S., Werner, M., Sund, M., Khaw, K.-T., Wareham, N., Travis, R.C., Norat, T., Wark, P.A., Riboli, E., Nöthlings, U., International Prevention Research Institute (IPRI), The Tisch Cancer Institute, and Icahn School of Medicine at Mount Sinai [New York] (MSSM)
Subjects: Male, Cancer Research, obesity, Weight Gain, Gastroenterology, Body Mass Index, Hepatocellular/*epidemiology/etiology Case-Control Studies Europe/epidemiology Female Hepatitis B/epidemiology Hepatitis C/epidemiology Humans Liver Neoplasms/*epidemiology/etiology Male Middle Aged Nutritional Status Obesity, Biliary Tract Neoplasms/*epidemiology/etiology Body Composition Body Mass Index Body Weight Carcinoma, hepatocellular carcinoma (HCC), 0302 clinical medicine, Waist–hip ratio, intrahepatic (IBDC), Prospective Studies, Prospective cohort study, Abdominal/*epidemiology Proportional Hazards Models Prospective Studies Waist-Hip Ratio *Weight Gain, Abdominal obesity, extrahepatic bile duct system cancer, 2. Zero hunger, Liver Neoplasms, weight gain, Middle Aged, Hepatitis B, Hepatitis C, 3. Good health, European Prospective Investigation into Cancer and Nutrition, Europe, Biliary Tract Neoplasms, Oncology, 030220 oncology & carcinogenesis, Obesity, Abdominal, Body Composition, 030211 gastroenterology & hepatology, Female, medicine.symptom, medicine.medical_specialty, Carcinoma, Hepatocellular, adulthood, liver and biliary tract cancer, Nutritional Status, abdominal obesity, 03 medical and health sciences, Internal medicine, medicine, Humans, Gallbladder cancer, Proportional Hazards Models, business.industry, Waist-Hip Ratio, Weight change, Body Weight, medicine.disease, Endocrinology, Relative risk, Case-Control Studies, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, Body mass index
Abstract: Schlesinger, Sabrina Aleksandrova, Krasimira Pischon, Tobias Fedirko, Veronika Jenab, Mazda Trepo, Elisabeth Boffetta, Paolo Dahm, Christina C Overvad, Kim Tjonneland, Anne Halkjaer, Jytte Fagherazzi, Guy Boutron-Ruault, Marie-Christine Carbonnel, Franck Kaaks, Rudolf Lukanova, Annekatrin Boeing, Heiner Trichopoulou, Antonia Bamia, Christina Lagiou, Pagona Palli, Domenico Grioni, Sara Panico, Salvatore Tumino, Rosario Vineis, Paolo Bueno-de-Mesquita, H B van den Berg, Saskia Peeters, Petra H M Braaten, Tonje Weiderpass, Elisabete Quiros, J Ramon Travier, Noemie Sanchez, Maria-Jose Navarro, Carmen Barricarte, Aurelio Dorronsoro, Miren Lindkvist, Bjorn Regner, Sara Werner, Marten Sund, Malin Khaw, Kay-Tee Wareham, Nicholas Travis, Ruth C Norat, Teresa Wark, Petra A Riboli, Elio Nothlings, Ute eng 11692/Cancer Research UK/United Kingdom G0401527/Medical Research Council/United Kingdom G1000143/Medical Research Council/United Kingdom MC_U106179471/Medical Research Council/United Kingdom British Heart Foundation/United Kingdom Cancer Research UK/United Kingdom Department of Health/United Kingdom Medical Research Council/United Kingdom Wellcome Trust/United Kingdom Research Support, Non-U.S. Gov't 2012/05/24 06:00 Int J Cancer. 2013 Feb 1;132(3):645-57. doi: 10.1002/ijc.27645. Epub 2012 Jun 13.; International audience; General obesity has been positively associated with risk of liver and probably with biliary tract cancer, but little is known about abdominal obesity or weight gain during adulthood. We used multivariable Cox proportional hazard models to investigate associations between weight, body mass index, waist and hip circumference, waist-to-hip and waist-to-height ratio (WHtR), weight change during adulthood and risk of hepatocellular carcinoma (HCC), intrahepatic (IBDC) and extrahepatic bile duct system cancer [EBDSC including gallbladder cancer (GBC)] among 359,525 men and women in the European Prospective Investigation into Cancer and Nutrition study. Hepatitis B and C virus status was measured in a nested case-control subset. During a mean follow-up of 8.6 years, 177 cases of HCC, 58 cases of IBDC and 210 cases of EBDSC, including 76 cases of GBC, occurred. All anthropometric measures were positively associated with risk of HCC and GBC. WHtR showed the strongest association with HCC [relative risk (RR) comparing extreme tertiles 3.51, 95% confidence interval (95% CI): 2.09-5.87; p(trend) < 0.0001] and with GBC (RR: 1.56, 95% CI: 1.12-2.16 for an increment of one unit in WHtR). Weight gain during adulthood was also positively associated with HCC when comparing extreme tertiles (RR: 2.48, 95% CI: 1.49-4.13
Published: 2013

15. Dietary total antioxidant capacity and gastriccancer risk in the European prospective investigation into cancer and nutritionstudy

Author: Serafini M, Jakszyn P, Luján L, Agudo A, Bas Bueno de Mesquita H, van Duijnhoven FJ, Jenab M, Navarro C, Palli D, Boeing H, Wallström P, Regnér S, Numans ME, Carneiro F, Boutron Ruault MC, Clavel Chapelon F, Morois S, Grioni S, Tumino R, Sacerdote C, Ramon Quirós J, Molina Montes E, Huerta Castaño JM, Barricarte A, Amiano P, Khaw KT, Wareham N, Allen NE, Key TJ, Jeurnink SM, Peeters PH, Bamia C, Valanou E, Trichopoulou A, Kaaks R, Lukanova A, Bergmann MM, Lindkvist B, Stenling R, Johansson I, Dahm CC, Overvad K, Jensen M, Olsen A, Tjonneland A, Bakken K, Dumeaux V, Lund E, McCormack V, Rinaldi S, Michaud D, Mouw T, Riboli E, González C.A., PANICO, SALVATORE, Serafini, M, Jakszyn, P, Luján, L, Agudo, A, Bas Bueno de Mesquita, H, van Duijnhoven, Fj, Jenab, M, Navarro, C, Palli, D, Boeing, H, Wallström, P, Regnér, S, Numans, Me, Carneiro, F, Boutron Ruault, Mc, Clavel Chapelon, F, Morois, S, Grioni, S, Panico, Salvatore, Tumino, R, Sacerdote, C, Ramon Quirós, J, Molina Montes, E, Huerta Castaño, Jm, Barricarte, A, Amiano, P, Khaw, Kt, Wareham, N, Allen, Ne, Key, Tj, Jeurnink, Sm, Peeters, Ph, Bamia, C, Valanou, E, Trichopoulou, A, Kaaks, R, Lukanova, A, Bergmann, Mm, Lindkvist, B, Stenling, R, Johansson, I, Dahm, Cc, Overvad, K, Jensen, M, Olsen, A, Tjonneland, A, Bakken, K, Dumeaux, V, Lund, E, Mccormack, V, Rinaldi, S, Michaud, D, Mouw, T, Riboli, E, and González, C. A.
Published: 2012

16. Pre-diagnostic 25-Hydroxyvitamin D, VDR and CASRPolymorphisms, and Survival in Patients with Colorectal Cancer in WesternEuropean Populations

Author: Fedirko V, Riboli E, Tjonneland A, Ferrari P, Olsen A, Bueno de Mesquita HB, van Duijnhoven F, Norat T, Jansen E, Dahm CC, Overvad K, Boutron Ruault MC, Clavel Chapelon F, Racine A, Lukanova A, Teucher B, Boeing H, Aleksandrova K, Trichopoulou A, Benetou V, Trichopoulos D, Grioni S, Vineis P, Palli D, Tumino R, Siersema PD, Peeters PH, Skeie G, Brustad M, Chirlaque MD, Barricarte Gurrea A, Quirós Garcia JR, Sanchez MJ, Dorronsoro M, Bonet C, Palmqvist R, Hallmans G, Key TJ, Crowe FL, Khaw KT, Wareham NJ, Romieu II, McKay J, Wark PA, Romaguera D, Jenab M., PANICO, SALVATORE, Fedirko, V, Riboli, E, Tjonneland, A, Ferrari, P, Olsen, A, Bueno de Mesquita, Hb, van Duijnhoven, F, Norat, T, Jansen, E, Dahm, Cc, Overvad, K, Boutron Ruault, Mc, Clavel Chapelon, F, Racine, A, Lukanova, A, Teucher, B, Boeing, H, Aleksandrova, K, Trichopoulou, A, Benetou, V, Trichopoulos, D, Grioni, S, Vineis, P, Panico, Salvatore, Palli, D, Tumino, R, Siersema, Pd, Peeters, Ph, Skeie, G, Brustad, M, Chirlaque, Md, Barricarte Gurrea, A, Quirós Garcia, Jr, Sanchez, Mj, Dorronsoro, M, Bonet, C, Palmqvist, R, Hallmans, G, Key, Tj, Crowe, Fl, Khaw, Kt, Wareham, Nj, Romieu, Ii, Mckay, J, Wark, Pa, Romaguera, D, and Jenab, M.
Published: 2012

17. Diabetes mellitus, glycatedhaemoglobin and C-peptide levels in relation to pancreatic cancer risk: a studywithin the European Prospective Investigation into Cancer and Nutrition (EPIC)cohort

Author: Grote VA, Rohrmann S, Nieters A, Dossus L, Tjønneland A, Halkjær J, Overvad K, Fagherazzi G, Boutron Ruault MC, Morois S, Teucher B, Becker S, Sluik D, Boeing H, Trichopoulou A, Lagiou P, Trichopoulos D, Palli D, Pala V, Tumino R, Vineis P, Rodríguez L, Duell EJ, Molina Montes E, Dorronsoro M, Huerta JM, Ardanaz E, Jeurnink SM, Beulens JW, Peeters PH, Sund M, Ye W, Lindkvist B, Johansen D, Khaw KT, Wareham N, Allen N, Crowe F, Jenab M, Romieu I, Michaud DS, Riboli E, Romaguera D, Bueno de Mesquita HB, Kaaks R., PANICO, SALVATORE, Grote, Va, Rohrmann, S, Nieters, A, Dossus, L, Tjønneland, A, Halkjær, J, Overvad, K, Fagherazzi, G, Boutron Ruault, Mc, Morois, S, Teucher, B, Becker, S, Sluik, D, Boeing, H, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Palli, D, Pala, V, Tumino, R, Vineis, P, Panico, Salvatore, Rodríguez, L, Duell, Ej, Molina Montes, E, Dorronsoro, M, Huerta, Jm, Ardanaz, E, Jeurnink, Sm, Beulens, Jw, Peeters, Ph, Sund, M, Ye, W, Lindkvist, B, Johansen, D, Khaw, Kt, Wareham, N, Allen, N, Crowe, F, Jenab, M, Romieu, I, Michaud, D, Riboli, E, Romaguera, D, Bueno de Mesquita, Hb, and Kaaks, R.
Published: 2011

18. Aberrant DNA methylation of cancer-associatedgenes in gastric cancer in the European Prospective Investigation into Cancer andNutrition (EPIC-EURGAST)

Author: Balassiano K, Lima S, Jenab M, Overvad K, Tjonneland A, Boutron Ruault MC, Clavel Chapelon F, Canzian F, Kaaks R, Boeing H, Meidtner K, Trichopoulou A, Laglou P, Vineis P, Palli D, Grioni S, Tumino R, Lund E, Bueno de Mesquita HB, Numans ME, Peeters PH, Ramon Quirós J, Sánchez MJ, Navarro C, Ardanaz E, Dorronsoro M, Hallmans G, Stenling R, Ehrnström R, Regner S, Allen NE, Travis RC, Khaw KT, Offerhaus GJ, Sala N, Riboli E, Hainaut P, Scoazec JY, Sylla BS, Gonzalez CA, Herceg Z., PANICO, SALVATORE, Balassiano, K, Lima, S, Jenab, M, Overvad, K, Tjonneland, A, Boutron Ruault, Mc, Clavel Chapelon, F, Canzian, F, Kaaks, R, Boeing, H, Meidtner, K, Trichopoulou, A, Laglou, P, Vineis, P, Panico, Salvatore, Palli, D, Grioni, S, Tumino, R, Lund, E, Bueno de Mesquita, Hb, Numans, Me, Peeters, Ph, Ramon Quirós, J, Sánchez, Mj, Navarro, C, Ardanaz, E, Dorronsoro, M, Hallmans, G, Stenling, R, Ehrnström, R, Regner, S, Allen, Ne, Travis, Rc, Khaw, Kt, Offerhaus, Gj, Sala, N, Riboli, E, Hainaut, P, Scoazec, Jy, Sylla, B, Gonzalez, Ca, and Herceg, Z.
Published: 2011

19. Metabolic syndrome and risks ofcolon and rectal cancer: the European prospective investigation into cancer andnutrition study

Author: Aleksandrova K, Boeing H, Jenab M, Bas Bueno de Mesquita H, Jansen E, van Duijnhoven FJ, Fedirko V, Rinaldi S, Romieu I, Riboli E, Romaguera D, Overvad K, Østergaard JN, Olsen A, Tjønneland A, Boutron Ruault MC, Clavel Chapelon F, Morois S, Masala G, Agnoli C, Tumino R, Vineis P, Kaaks R, Lukanova A, Trichopoulou A, Naska A, Bamia C, Peeters PH, Rodríguez L, Buckland G, Sánchez MJ, Dorronsoro M, Huerta JM, Barricarte A, Hallmans G, Palmqvist R, Khaw KT, Wareham N, Allen NE, Tsilidis KK, Pischon T., PANICO, SALVATORE, Aleksandrova, K, Boeing, H, Jenab, M, Bas Bueno de Mesquita, H, Jansen, E, van Duijnhoven, Fj, Fedirko, V, Rinaldi, S, Romieu, I, Riboli, E, Romaguera, D, Overvad, K, Østergaard, Jn, Olsen, A, Tjønneland, A, Boutron Ruault, Mc, Clavel Chapelon, F, Morois, S, Masala, G, Agnoli, C, Panico, Salvatore, Tumino, R, Vineis, P, Kaaks, R, Lukanova, A, Trichopoulou, A, Naska, A, Bamia, C, Peeters, Ph, Rodríguez, L, Buckland, G, Sánchez, Mj, Dorronsoro, M, Huerta, Jm, Barricarte, A, Hallmans, G, Palmqvist, R, Khaw, Kt, Wareham, N, Allen, Ne, Tsilidis, Kk, and Pischon, T.
Published: 2011

20. Dietary intake of heme iron and risk of gastriccancer in the European prospective investigation into cancer and nutrition(EURGAST- EPIC) study

Author: Jakszyn P, Agudo A, Lujan Barroso L, Bueno de Mesquita HB, Jenab M, Navarro C, Palli D, Boeing H, Manjer J, Numans ME, Igali L, Boutron Ruault MC, Clavel Chapelon F, Morois S, Grioni S, Tumino R, Sacerdote C, Quirós JR, Molina Montes E, Castaño JM, Barricarte A, Amiano P, Khaw KT, Wareham N, Allen NE, Key TJ, Jeurnink SM, Peeters PH, Bamia C, Valanou E, Trichopoulou A, Kaaks R, Lukanova A, Bergmann MM, Lindkvist B, Stenling R, Johansson I, Dahm CC, Overvad K, Olsen A, Tjonneland A, Skeie G, Broderstad AR, Lund E, Michaud DS, Mouw T, Riboli E, González C.A., PANICO, SALVATORE, Jakszyn, P, Agudo, A, Lujan Barroso, L, Bueno de Mesquita, Hb, Jenab, M, Navarro, C, Palli, D, Boeing, H, Manjer, J, Numans, Me, Igali, L, Boutron Ruault, Mc, Clavel Chapelon, F, Morois, S, Grioni, S, Panico, Salvatore, Tumino, R, Sacerdote, C, Quirós, Jr, Molina Montes, E, Castaño, Jm, Barricarte, A, Amiano, P, Khaw, Kt, Wareham, N, Allen, Ne, Key, Tj, Jeurnink, Sm, Peeters, Ph, Bamia, C, Valanou, E, Trichopoulou, A, Kaaks, R, Lukanova, A, Bergmann, Mm, Lindkvist, B, Stenling, R, Johansson, I, Dahm, Cc, Overvad, K, Olsen, A, Tjonneland, A, Skeie, G, Broderstad, Ar, Lund, E, Michaud, D, Mouw, T, Riboli, E, and González, C. A.
Published: 2011

21. Variety in vegetable and fruit consumption and risk of bladder cancer in theEuropean Prospective Investigation into Cancer and Nutrition

Author: Büchner FL, Bueno de Mesquita HB, Ros MM, Kampman E, Egevad L, Overvad K, Tjønneland A, Roswall N, Clavel Chapelon F, Boutron Ruault MC, Touillaud M, Kaaks R, Chang Claude J, Boeing H, Weikert S, Trichopoulou A, Naska A, Benetou V, Palli D, Sieri S, Vineis P, Tumino R, van Duijnhoven FJ, Peeters PH, van Gils CH, Lund E, Gram IT, Sánchez MJ, Jakszyn P, Larrañaga N, Ardanaz E, Navarro C, Rodríguez L, Manjer J, Ehrnström R, Hallmans G, Ljungberg B, Key TJ, Allen NE, Khaw KT, Wareham N, Slimani N, Jenab M, Boffetta P, Kiemeney LA, Riboli E., PANICO, SALVATORE, Büchner, Fl, Bueno de Mesquita, Hb, Ros, Mm, Kampman, E, Egevad, L, Overvad, K, Tjønneland, A, Roswall, N, Clavel Chapelon, F, Boutron Ruault, Mc, Touillaud, M, Kaaks, R, Chang Claude, J, Boeing, H, Weikert, S, Trichopoulou, A, Naska, A, Benetou, V, Palli, D, Sieri, S, Vineis, P, Tumino, R, Panico, Salvatore, van Duijnhoven, Fj, Peeters, Ph, van Gils, Ch, Lund, E, Gram, It, Sánchez, Mj, Jakszyn, P, Larrañaga, N, Ardanaz, E, Navarro, C, Rodríguez, L, Manjer, J, Ehrnström, R, Hallmans, G, Ljungberg, B, Key, Tj, Allen, Ne, Khaw, Kt, Wareham, N, Slimani, N, Jenab, M, Boffetta, P, Kiemeney, La, and Riboli, E.
Published: 2011

22. Mediterraneandietary pattern and cancer risk in the EPIC cohort

Author: Couto E, Boffetta P, Lagiou P, Ferrari P, Buckland G, Overvad K, Dahm CC, Tjønneland A, Olsen A, Clavel Chapelon F, Boutron Ruault MC, Cottet V, Trichopoulos D, Naska A, Benetou V, Kaaks R, Rohrmann S, Boeing H, von Ruesten A, Pala V, Vineis P, Palli D, Tumino R, May A, Peeters PH, Bueno de Mesquita HB, Büchner FL, Lund E, Skeie G, Engeset D, Gonzalez CA, Navarro C, Rodríguez L, Sánchez MJ, Amiano P, Barricarte A, Hallmans G, Johansson I, Manjer J, Wirfärt E, Allen NE, Crowe F, Khaw KT, Wareham N, Moskal A, Slimani N, Jenab M, Romaguera D, Mouw T, Norat T, Riboli E, Trichopoulou A., PANICO, SALVATORE, Couto, E, Boffetta, P, Lagiou, P, Ferrari, P, Buckland, G, Overvad, K, Dahm, Cc, Tjønneland, A, Olsen, A, Clavel Chapelon, F, Boutron Ruault, Mc, Cottet, V, Trichopoulos, D, Naska, A, Benetou, V, Kaaks, R, Rohrmann, S, Boeing, H, von Ruesten, A, Panico, Salvatore, Pala, V, Vineis, P, Palli, D, Tumino, R, May, A, Peeters, Ph, Bueno de Mesquita, Hb, Büchner, Fl, Lund, E, Skeie, G, Engeset, D, Gonzalez, Ca, Navarro, C, Rodríguez, L, Sánchez, Mj, Amiano, P, Barricarte, A, Hallmans, G, Johansson, I, Manjer, J, Wirfärt, E, Allen, Ne, Crowe, F, Khaw, Kt, Wareham, N, Moskal, A, Slimani, N, Jenab, M, Romaguera, D, Mouw, T, Norat, T, Riboli, E, and Trichopoulou, A.
Published: 2011

23. Prediagnosticcirculating parathyroid hormone concentration and colorectal cancer in theEuropean Prospective Investigation into Cancer and Nutrition cohort

Author: Fedirko V, Riboli E, Bueno de Mesquita HB, Rinaldi S, Pischon T, Norat T, Jansen EH, van Duijnhoven FJ, Tjønneland A, Olsen A, Overvad K, Boutron Ruault MC, Clavel Chapelon F, Engel P, Kaaks R, Teucher B, Boeing H, Buijsse B, Trichopoulou A, Trichopoulos D, Lagiou P, Sieri S, Vineis P, Palli D, Tumino R, van Gils CH, Peeters PH, Chirlaque MD, Gurrea AB, Rodríguez L, Molina Montes E, Dorronsoro M, Bonet C, Palmqvist R, Hallmans G, Key TJ, Tsilidis KK, Khaw KT, Romieu I, Straif K, Wark PA, Romaguera D, Jenab M., PANICO, SALVATORE, Fedirko, V, Riboli, E, Bueno de Mesquita, Hb, Rinaldi, S, Pischon, T, Norat, T, Jansen, Eh, van Duijnhoven, Fj, Tjønneland, A, Olsen, A, Overvad, K, Boutron Ruault, Mc, Clavel Chapelon, F, Engel, P, Kaaks, R, Teucher, B, Boeing, H, Buijsse, B, Trichopoulou, A, Trichopoulos, D, Lagiou, P, Sieri, S, Vineis, P, Panico, Salvatore, Palli, D, Tumino, R, van Gils, Ch, Peeters, Ph, Chirlaque, Md, Gurrea, Ab, Rodríguez, L, Molina Montes, E, Dorronsoro, M, Bonet, C, Palmqvist, R, Hallmans, G, Key, Tj, Tsilidis, Kk, Khaw, Kt, Romieu, I, Straif, K, Wark, Pa, Romaguera, D, and Jenab, M.
Published: 2011

24. Educational level and risk of colorectalcancer in EPIC with specific reference to tumor location

Author: Leufkens AM, Van Duijnhoven FJ, Boshuizen HC, Siersema PD, Kunst AE, Mouw T, Tjønneland A, Olsen A, Overvad K, Boutron Ruault MC, Clavel Chapelon F, Morois S, Krogh V, Tumino R, Polidoro S, Palli D, Kaaks R, Teucher B, Pischon T, Trichopoulou A, Orfanos P, Goufa I, Peeters PH, Skeie G, Braaten T, Rodríguez L, Lujan Barroso L, Sánchez Pérez MJ, Navarro C, Barricarte A, Zackrisson S, Almquist M, Hallmans G, Palmqvist R, Tsilidis KK, Khaw KT, Wareham N, Gallo V, Jenab M, Riboli E, Bueno de Mesquita H.B., PANICO, SALVATORE, Leufkens, Am, Van Duijnhoven, Fj, Boshuizen, Hc, Siersema, Pd, Kunst, Ae, Mouw, T, Tjønneland, A, Olsen, A, Overvad, K, Boutron Ruault, Mc, Clavel Chapelon, F, Morois, S, Krogh, V, Tumino, R, Panico, Salvatore, Polidoro, S, Palli, D, Kaaks, R, Teucher, B, Pischon, T, Trichopoulou, A, Orfanos, P, Goufa, I, Peeters, Ph, Skeie, G, Braaten, T, Rodríguez, L, Lujan Barroso, L, Sánchez Pérez, Mj, Navarro, C, Barricarte, A, Zackrisson, S, Almquist, M, Hallmans, G, Palmqvist, R, Tsilidis, Kk, Khaw, Kt, Wareham, N, Gallo, V, Jenab, M, Riboli, E, and Bueno de Mesquita, H. B.
Published: 2011

25. Genetic polymorphisms in 15q25 and 19q13 loci, cotininelevels, and risk of lung cancer in EPIC

Author: Timofeeva MN, McKay JD, Smith GD, Johansson M, Byrnes GB, Chabrier A, Relton C, Ueland PM, Vollset SE, Midttun Ø, Nygård O, Slimani N, Romieu I, Clavel Chapelon F, Boutron Ruault MC, Fagherazzi G, Kaaks R, Teucher B, Boeing H, Weikert C, Bueno de Mesquita HB, van Gils C, Peeters PH, Agudo A, Barricarte A, Huerta JM, Rodríguez L, Sánchez MJ, Larrañaga N, Khaw KT, Wareham N, Allen NE, Travis RC, Gallo V, Norat T, Krogh V, Masala G, Sacerdote C, Tumino R, Trichopoulou A, Lagiou P, Trichopoulos D, Rasmuson T, Hallmans G, Riboli E, Vineis P, Brennan P., PANICO, SALVATORE, Timofeeva, Mn, Mckay, Jd, Smith, Gd, Johansson, M, Byrnes, Gb, Chabrier, A, Relton, C, Ueland, Pm, Vollset, Se, Midttun, Ø, Nygård, O, Slimani, N, Romieu, I, Clavel Chapelon, F, Boutron Ruault, Mc, Fagherazzi, G, Kaaks, R, Teucher, B, Boeing, H, Weikert, C, Bueno de Mesquita, Hb, van Gils, C, Peeters, Ph, Agudo, A, Barricarte, A, Huerta, Jm, Rodríguez, L, Sánchez, Mj, Larrañaga, N, Khaw, Kt, Wareham, N, Allen, Ne, Travis, Rc, Gallo, V, Norat, T, Krogh, V, Masala, G, Panico, Salvatore, Sacerdote, C, Tumino, R, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Rasmuson, T, Hallmans, G, Riboli, E, Vineis, P, and Brennan, P.
Published: 2011

26. Smoking, secondhand smoke, and cotinine levels in a subset of EPICcohort

Author: Baltar VT, Xun WW, Chuang SC, Relton C, Ueland PM, Vollset SE, Midttun Ø, Johansson M, Slimani N, Jenab M, Clavel Chapelon F, Boutron Ruault MC, Fagherazzi G, Kaaks R, Rohrmann S, Boeing H, Weikert C, Bueno de Mesquita HB, Boshuizen HC, van Gils CH, Peeters PH, Agudo A, Barricarte A, Navarro C, Rodríguez L, Castaño JM, Larrañaga N, Pérez MJ, Khaw KT, Wareham N, Allen NE, Crowe F, Gallo V, Norat T, Tagliabue G, Masala G, Sacerdote C, Tumino R, Trichopoulou A, Lagiou P, Bamia C, Rasmuson T, Hallmans G, Roswall N, Tjønneland A, Riboli E, Brennan P, Vineis P., PANICO, SALVATORE, Baltar, Vt, Xun, Ww, Chuang, Sc, Relton, C, Ueland, Pm, Vollset, Se, Midttun, Ø, Johansson, M, Slimani, N, Jenab, M, Clavel Chapelon, F, Boutron Ruault, Mc, Fagherazzi, G, Kaaks, R, Rohrmann, S, Boeing, H, Weikert, C, Bueno de Mesquita, Hb, Boshuizen, Hc, van Gils, Ch, Peeters, Ph, Agudo, A, Barricarte, A, Navarro, C, Rodríguez, L, Castaño, Jm, Larrañaga, N, Pérez, Mj, Khaw, Kt, Wareham, N, Allen, Ne, Crowe, F, Gallo, V, Norat, T, Tagliabue, G, Masala, G, Panico, Salvatore, Sacerdote, C, Tumino, R, Trichopoulou, A, Lagiou, P, Bamia, C, Rasmuson, T, Hallmans, G, Roswall, N, Tjønneland, A, Riboli, E, Brennan, P, and Vineis, P.
Published: 2011

27. Variation in genescoding for AMP-activated protein kinase (AMPK) and breast cancer risk in theEuropean Prospective Investigation on Cancer (EPIC)

Author: Campa D, Claus R, Dostal L, Stein A, Chang Claude J, Meidtner K, Boeing H, Olsen A, Tjønneland A, Overvad K, Rodríguez L, Bonet C, Sánchez MJ, Amiano P, Huerta JM, Barricarte A, Khaw KT, Wareham N, Travis RC, Allen NE, Trichopoulou A, Bamia C, Benetou V, Palli D, Agnoli C, Tumino R, Sacerdote C, van Kranen H, Bas Bueno de Mesquita H, Peeters PH, van Gils CH, Lenner P, Sund M, Lund E, Gram IT, Rinaldi S, Chajes V, Romieu I, Engel P, Boutron Ruault MC, Clavel Chapelon F, Siddiq A, Riboli E, Canzian F, Kaaks R., PANICO, SALVATORE, Campa, D, Claus, R, Dostal, L, Stein, A, Chang Claude, J, Meidtner, K, Boeing, H, Olsen, A, Tjønneland, A, Overvad, K, Rodríguez, L, Bonet, C, Sánchez, Mj, Amiano, P, Huerta, Jm, Barricarte, A, Khaw, Kt, Wareham, N, Travis, Rc, Allen, Ne, Trichopoulou, A, Bamia, C, Benetou, V, Palli, D, Agnoli, C, Panico, Salvatore, Tumino, R, Sacerdote, C, van Kranen, H, Bas Bueno de Mesquita, H, Peeters, Ph, van Gils, Ch, Lenner, P, Sund, M, Lund, E, Gram, It, Rinaldi, S, Chajes, V, Romieu, I, Engel, P, Boutron Ruault, Mc, Clavel Chapelon, F, Siddiq, A, Riboli, E, Canzian, F, and Kaaks, R.
Published: 2011

28. Cigarette smoking, environmental tobacco smoke exposure and pancreatic cancer risk in the European Prospective Investigationinto Cancer and Nutrition

Author: Vrieling A, Bueno de Mesquita HB, Boshuizen HC, Michaud DS, Severinsen MT, Overvad K, Olsen A, Tjønneland A, Clavel Chapelon F, Boutron Ruault MC, Kaaks R, Rohrmann S, Boeing H, Nöthlings U, Trichopoulou A, Moutsiou E, Dilis V, Palli D, Krogh V, Tumino R, Vineis P, van Gils CH, Peeters PH, Lund E, Gram IT, Rodríguez L, Agudo A, Larrañaga N, Sánchez MJ, Navarro C, Barricarte A, Manjer J, Lindkvist B, Sund M, Ye W, Bingham S, Khaw KT, Roddam A, Key T, Boffetta P, Duell EJ, Jenab M, Gallo V, Riboli E., PANICO, SALVATORE, Vrieling, A, Bueno de Mesquita, Hb, Boshuizen, Hc, Michaud, D, Severinsen, Mt, Overvad, K, Olsen, A, Tjønneland, A, Clavel Chapelon, F, Boutron Ruault, Mc, Kaaks, R, Rohrmann, S, Boeing, H, Nöthlings, U, Trichopoulou, A, Moutsiou, E, Dilis, V, Palli, D, Krogh, V, Panico, Salvatore, Tumino, R, Vineis, P, van Gils, Ch, Peeters, Ph, Lund, E, Gram, It, Rodríguez, L, Agudo, A, Larrañaga, N, Sánchez, Mj, Navarro, C, Barricarte, A, Manjer, J, Lindkvist, B, Sund, M, Ye, W, Bingham, S, Khaw, Kt, Roddam, A, Key, T, Boffetta, P, Duell, Ej, Jenab, M, Gallo, V, and Riboli, E.
Published: 2010

29. Serum levels of IGF-I, IGFBP-3 and colorectal cancer risk:results from the EPIC cohort, plus a meta-analysis of prospective studies

Author: Rinaldi S, Cleveland R, Norat T, Biessy C, Rohrmann S, Linseisen J, Boeing H, Pischon T, Agnoli C, Palli D, Tumino R, Vineis P, Peeters PH, van Gils CH, Bueno de Mesquita BH, Vrieling A, Allen NE, Roddam A, Bingham S, Khaw KT, Manjer J, Borgquist S, Dumeaux V, Torhild Gram I, Lund E, Trichopoulou A, Makrygiannis G, Benetou V, Molina E, Donate Suárez I, Barricarte Gurrea A, Gonzalez CA, Tormo MJ, Altzibar JM, Olsen A, Tjonneland A, Grønbaek H, Overvad K, Clavel Chapelon F, Boutron Ruault MC, Morois S, Slimani N, Boffetta P, Jenab M, Riboli E, Kaaks R., PANICO, SALVATORE, Rinaldi, S, Cleveland, R, Norat, T, Biessy, C, Rohrmann, S, Linseisen, J, Boeing, H, Pischon, T, Panico, Salvatore, Agnoli, C, Palli, D, Tumino, R, Vineis, P, Peeters, Ph, van Gils, Ch, Bueno de Mesquita, Bh, Vrieling, A, Allen, Ne, Roddam, A, Bingham, S, Khaw, Kt, Manjer, J, Borgquist, S, Dumeaux, V, Torhild Gram, I, Lund, E, Trichopoulou, A, Makrygiannis, G, Benetou, V, Molina, E, Donate Suárez, I, Barricarte Gurrea, A, Gonzalez, Ca, Tormo, Mj, Altzibar, Jm, Olsen, A, Tjonneland, A, Grønbaek, H, Overvad, K, Clavel Chapelon, F, Boutron Ruault, Mc, Morois, S, Slimani, N, Boffetta, P, Jenab, M, Riboli, E, and Kaaks, R.
Published: 2010

30. Coffee and tea consumption, genotype-based CYP1A2 and NAT2 activity and colorectal cancer risk - Results from the EPIC cohort study

Author: Dik, VK, Bueno-De-Mesquita, HB, Van Oijen, MGH, Siersema, PD, Uiterwaal, CSPM, Van Gils, CH, Van Duijnhoven, FJB, Cauchi, S, Yengo, L, Froguel, P, Overvad, K, Bech, BH, Tjønneland, A, Olsen, A, Boutron-Ruault, MC, Racine, A, Fagherazzi, G, Kühn, T, Campa, D, Boeing, H, Aleksandrova, K, Trichopoulou, A, Peppa, E, Oikonomou, E, Palli, D, Grioni, S, Vineis, P, Tumino, R, Panico, S, Peeters, PHM, Weiderpass, E, Engeset, D, Braaten, T, Dorronsoro, M, Chirlaque, MD, Sánchez, MJ, Barricarte, A, Zamora-Ros, R, Argüelles, M, Jirström, K, Wallström, P, Nilsson, LM, Ljuslinder, I, Travis, RC, Khaw, KT, Wareham, N, Freisling, H, Licaj, I, Jenab, M, Gunter, MJ, Murphy, N, Romaguera-Bosch, D, and Riboli, E
Abstract: Coffee and tea contain numerous antimutagenic and antioxidant components and high levels of caffeine that may protect against colorectal cancer (CRC). We investigated the association between coffee and tea consumption and CRC risk and studied potential effect modification by CYP1A2 and NAT2 genotypes, enzymes involved in the metabolization of caffeine. Data from 477,071 participants (70.2% female) of the European Investigation into Cancer and Nutrition (EPIC) cohort study were analyzed. At baseline (1992-2000) habitual (total, caffeinated and decaffeinated) coffee and tea consumption was assessed with dietary questionnaires. Cox proportional hazards models were used to estimate adjusted hazard ratio's (HR) and 95% confidence intervals (95% CI). Potential effect modification by genotype-based CYP1A2 and NAT2 activity was studied in a nested case-control set of 1,252 cases and 2,175 controls. After a median follow-up of 11.6 years, 4,234 participants developed CRC (mean age 64.7-±-8.3 years). Total coffee consumption (high vs. non/low) was not associated with CRC risk (HR 1.06, 95% CI 0.95-1.18) or subsite cancers, and no significant associations were found for caffeinated (HR 1.10, 95% CI 0.97-1.26) and decaffeinated coffee (HR 0.96, 95% CI 0.84-1.11) and tea (HR 0.97, 95% CI 0.86-1.09). High coffee and tea consuming subjects with slow CYP1A2 or NAT2 activity had a similar CRC risk compared to non/low coffee and tea consuming subjects with a fast CYP1A2 or NAT2 activity, which suggests that caffeine metabolism does not affect the link between coffee and tea consumption and CRC risk. This study shows that coffee and tea consumption is not likely to be associated with overall CRC. What's new? Coffee and tea contain numerous compounds that may protect against colorectal cancer (CRC). In this study of more than 475,000 participants over more than a decade, the authors investigated whether coffee or tea consumption is associated with an altered risk of developing CRC. They also asked whether genetic variations in two enzymes involved in caffeine metabolism (CYP1A2 and NAT2) might affect this risk. They conclude that neither consumption patterns, nor genetic differences in caffeine metabolism, appear to have a significant impact on CRC risk. © 2013 UICC.
Published: 2014

31. Adherence to the Mediterranean diet and risk of bladder cancer in the EPIC cohort study

Author: Buckland, G, Ros, MM, Roswall, N, Bueno-De-Mesquita, HB, Travier, N, Tjonneland, A, Kiemeney, LA, Sacerdote, C, Tumino, R, Ljungberg, B, Gram, IT, Weiderpass, E, Skeie, G, Malm, J, Ehrnström, R, Chang-Claude, J, Mattiello, A, Agnoli, C, Peeters, PH, Boutron-Ruault, MC, Fagherazzi, G, Clavel-Chapelon, F, Nilsson, LM, Amiano, P, Trichopoulou, A, Oikonomou, E, Tsiotas, K, Sánchez, MJ, Overvad, K, Quirõs, JR, Chirlaque, MD, Barricarte, A, Key, TJ, Allen, NE, Khaw, KT, Wareham, N, Riboli, E, Kaaks, R, Boeing, H, Palli, D, Romieu, I, Romaguera, D, and Gonzalez, CA
Subjects: Male, Carcinoma, Transitional Cell, Time Factors, Smoking, Middle Aged, Diet, Mediterranean, Diet Surveys, Risk Assessment, Body Mass Index, Europe, Food Preferences, Urinary Bladder Neoplasms, Risk Factors, Surveys and Questionnaires, Urological cancers Radboud Institute for Health Sciences [Radboudumc 15], Outcome Assessment, Health Care, Humans, Female, Prospective Studies, Aged, Proportional Hazards Models
Abstract: Item does not contain fulltext There is growing evidence of the protective role of the Mediterranean diet (MD) on cancer. However, to date no epidemiological study has investigated the influence of the MD on bladder cancer. We evaluated the association between adherence to the MD and risk of urothelial cell bladder cancer (UCC), according to tumor aggressiveness, in the European Prospective Investigation into Cancer and Nutrition (EPIC). The analysis included 477,312 participants, recruited from ten European countries between 1991 and 2000. Information from validated dietary questionnaires was used to develop a relative Mediterranean diet score (rMED), including nine dietary components. Cox regression models were used to assess the effect of the rMED on UCC risk, while adjusting for dietary energy and tobacco smoking of any kind. Stratified analyses were performed by sex, BMI, smoking status, European region and age at diagnosis. During an average follow-up of 11 years, 1,425 participants (70.9% male) were diagnosed with a first primary UCC. There was a negative but non-significant association between a high versus low rMED score and risk of UCC overall (HR: 0.84 [95% CI 0.69, 1.03]) and risk of aggressive (HR: 0.88 [95% CI 0.61, 1.28]) and non-aggressive tumors (HR: 0.78 [95% CI 0.54, 1.14]). Although there was no effect modification in the stratified analyses, there was a significant 34% (p = 0.043) decreased risk of UCC in current smokers with a high rMED score. In EPIC, the MD was not significantly associated with risk of UCC, although we cannot exclude that a MD may reduce risk in current smokers.
Published: 2014

32. Intake of vegetables, legumes, and fruit, and risk for all-cause, cardiovascular, and cancer mortality in a European diabeticpopulation

Author: Nöthlings U, Schulze MB, Weikert C, Boeing H, van der Schouw YT, Bamia C, Benetou V, Lagiou P, Krogh V, Beulens JW, Peeters PH, Halkjaer J, Tjønneland A, Tumino R, Masala G, Clavel Chapelon F, de Lauzon B, Boutron Ruault MC, Vercambre MN, Kaaks R, Linseisen J, Overvad K, Arriola L, Ardanaz E, Gonzalez CA, Tormo MJ, Bingham S, Khaw KT, Key TJ, Vineis P, Riboli E, Ferrari P, Boffetta P, Bueno de Mesquita HB, van der A. DL, Berglund G, Wirfält E, Hallmans G, Johansson I, Lund E, Trichopoulo A., PANICO, SALVATORE, Nöthlings, U, Schulze, Mb, Weikert, C, Boeing, H, van der Schouw, Yt, Bamia, C, Benetou, V, Lagiou, P, Krogh, V, Beulens, Jw, Peeters, Ph, Halkjaer, J, Tjønneland, A, Tumino, R, Panico, Salvatore, Masala, G, Clavel Chapelon, F, de Lauzon, B, Boutron Ruault, Mc, Vercambre, Mn, Kaaks, R, Linseisen, J, Overvad, K, Arriola, L, Ardanaz, E, Gonzalez, Ca, Tormo, Mj, Bingham, S, Khaw, Kt, Key, Tj, Vineis, P, Riboli, E, Ferrari, P, Boffetta, P, Bueno de Mesquita, Hb, van der A., Dl, Berglund, G, Wirfält, E, Hallmans, G, Johansson, I, Lund, E, and Trichopoulo, A.
Published: 2008

33. Dietary fat and breast cancer risk in the European ProspectiveInvestigation into Cancer and Nutrition

Author: Sieri S, Krogh V, Ferrari P, Berrino F, Pala V, Thiébaut AC, Tjønneland A, Olsen A, Overvad K, Jakobsen MU, Clavel Chapelon F, Chajes V, Boutron Ruault MC, Kaaks R, Linseisen J, Boeing H, Nöthlings U, Trichopoulou A, Naska A, Lagiou P, Palli D, Vineis P, Tumino R, Lund E, Kumle M, Skeie G, González CA, Ardanaz E, Amiano P, Tormo MJ, Martínez García C, Quirós JR, Berglund G, Gullberg B, Hallmans G, Lenner P, Bueno de Mesquita HB, van Duijnhoven FJ, Peeters PH, van Gils CH, Key TJ, Crowe FL, Bingham S, Khaw KT, Rinaldi S, Slimani N, Jenab M, Norat T, Riboli E., PANICO, SALVATORE, Sieri, S, Krogh, V, Ferrari, P, Berrino, F, Pala, V, Thiébaut, Ac, Tjønneland, A, Olsen, A, Overvad, K, Jakobsen, Mu, Clavel Chapelon, F, Chajes, V, Boutron Ruault, Mc, Kaaks, R, Linseisen, J, Boeing, H, Nöthlings, U, Trichopoulou, A, Naska, A, Lagiou, P, Panico, Salvatore, Palli, D, Vineis, P, Tumino, R, Lund, E, Kumle, M, Skeie, G, González, Ca, Ardanaz, E, Amiano, P, Tormo, Mj, Martínez García, C, Quirós, Jr, Berglund, G, Gullberg, B, Hallmans, G, Lenner, P, Bueno de Mesquita, Hb, van Duijnhoven, Fj, Peeters, Ph, van Gils, Ch, Key, Tj, Crowe, Fl, Bingham, S, Khaw, Kt, Rinaldi, S, Slimani, N, Jenab, M, Norat, T, and Riboli, E.
Published: 2008

34. Cereal fiber intake may reduce risk of gastric adenocarcinomas: the EPIC-EURGAST study

Author: PERA G, AGUDO A, BUENO DE MESQUITA HB, PALLI D, BOEING H, CARNEIRO F, BERRINO F, SACERDOTE C, TUMINO R, BERGLUND G, MANJER J, JOHANSSON I, STENLING R, MARTINEZ C, DORRONSORO M, BARRICARTE A, TORMO MJ, QUIROS JR, ALLEN N, KEY TJ, BINGHAM S, LINSEISEN J, KAAKS R, OVERVAD K, JENSEN M, OLSEN A, TJONNELAND A, PEETERS PH, NUMANS ME, OCKE MC, CLAVEL CHAPELON F, BOUTRON RUAULT MC, TRICHOPOULOU A, LUND E, SLIMANI N, JENAB M, FERRARI P, RIBOLI E, GONZALEZ CA, PANICO, SALVATORE, Pera, G, Agudo, A, BUENO DE MESQUITA, Hb, Palli, D, Boeing, H, Carneiro, F, Berrino, F, Sacerdote, C, Tumino, R, Panico, Salvatore, Berglund, G, Manjer, J, Johansson, I, Stenling, R, Martinez, C, Dorronsoro, M, Barricarte, A, Tormo, Mj, Quiros, Jr, Allen, N, Key, Tj, Bingham, S, Linseisen, J, Kaaks, R, Overvad, K, Jensen, M, Olsen, A, Tjonneland, A, Peeters, Ph, Numans, Me, Ocke, Mc, CLAVEL CHAPELON, F, BOUTRON RUAULT, Mc, Trichopoulou, A, Lund, E, Slimani, N, Jenab, M, Ferrari, P, Riboli, E, and Gonzalez, Ca
Published: 2007

35. Polymorphisms in metabolic genes related to tobacco smoke and the risk of gastric cancer in the European prospective investigation into cancer and nutrition

Author: AGUDO A, SALA N, PERA G, CAPELLA G, BERENGUER A, GARCIA N, PALLI D, BOEING, H, DEL GIUDICE G, SAIEVA C, CARNEIRO F, BERRINO F, SACERDOTE C, TUMINO R, S, BERGLUND G, SIMAN H, STENLING R, HALLMANS G, MARTINEZ C, BILBAO R, BARRICARTE, A, NAVARRO C, QUIROS JR, ALLEN N, KEY T, BINGHAM S, KHAW KT, LINSEISEN J, NAGEL, G, OVERVAD K, TJONNELAND A, OLSEN A, BUENO DE MESQUITA HB, BOSHUIZEN HC, PEETERS, PH, NUMANS ME, CLAVEL CHAPELON F, BOUTRON RUAULT MC, TRICHOPOULOU A, LUND E, OFFERHAUS J, JENAB M, FERRARI P, NORAT T, RIBOLI E, GONZALEZ CA, PANICO, SALVATORE, Agudo, A, Sala, N, Pera, G, Capella, G, Berenguer, A, Garcia, N, Palli, D, Boeing, H, DEL GIUDICE, G, Saieva, C, Carneiro, F, Berrino, F, Sacerdote, C, Tumino, R, Panico, Salvatore, S, Berglund, G, Siman, H, Stenling, R, Hallmans, G, Martinez, C, Bilbao, R, Barricarte, A, Navarro, C, Quiros, Jr, Allen, N, Key, T, Bingham, S, Khaw, Kt, Linseisen, J, Nagel, G, Overvad, K, Tjonneland, A, Olsen, A, BUENO DE MESQUITA, Hb, Boshuizen, Hc, Peeters, Ph, Numans, Me, CLAVEL CHAPELON, F, BOUTRON RUAULT, Mc, Trichopoulou, A, Lund, E, Offerhaus, J, Jenab, M, Ferrari, P, Norat, T, Riboli, E, and Gonzalez, Ca
Published: 2006

36. No association between polymorphisms in CYP2E1, GSTM1, NAT1, NAT2 and the risk of gastric adenocarcinoma in the European prospective investigation into cancer and nutrition

Author: AGUDO A, SALA N, PERA G, CAPELLA G, BERENGUER A, GARCIA N, PALLI D, BOEING, H, DEL GIUDICE G, SAIEVA C, CARNEIRO F, BERRINO F, SACERDOTE C, TUMINO R, S, BERGLUND G, SIMAN H, STENLING R, HALLMANS G, MARTINEZ C, AMIANO P, BARRICARTE, A, NAVARRO C, QUIROS JR, ALLEN N, KEY T, BINGHAM S, KHAW KT, LINSEISEN J, NAGEL, G, OVERVAD K, TJONNELAND A, OLSEN A, BUENO DE MESQUITA HB, BOSHUIZEN HC, PEETERS, PH, NUMANS ME, CLAVEL CHAPELON F, BOUTRON RUAULT MC, TRICHOPOULOU A, LUND E, BLAKER H, JENAB M, FERRARI P, NORAT T, RIBOLI E, GONZALEZ CA, PANICO, SALVATORE, Agudo, A, Sala, N, Pera, G, Capella, G, Berenguer, A, Garcia, N, Palli, D, Boeing, H, DEL GIUDICE, G, Saieva, C, Carneiro, F, Berrino, F, Sacerdote, C, Tumino, R, Panico, Salvatore, S, Berglund, G, Siman, H, Stenling, R, Hallmans, G, Martinez, C, Amiano, P, Barricarte, A, Navarro, C, Quiros, Jr, Allen, N, Key, T, Bingham, S, Khaw, Kt, Linseisen, J, Nagel, G, Overvad, K, Tjonneland, A, Olsen, A, BUENO DE MESQUITA, Hb, Boshuizen, Hc, Peeters, Ph, Numans, Me, CLAVEL CHAPELON, F, BOUTRON RUAULT, Mc, Trichopoulou, A, Lund, E, Blaker, H, Jenab, M, Ferrari, P, Norat, T, Riboli, E, and Gonzalez, Ca
Published: 2006

37. Meal patterns across ten European countries – results from the European Prospective Investigation into Cancer and Nutrition (EPIC) calibration study

Author: Huseinovic, E, primary, Winkvist, A, additional, Slimani, N, additional, Park, MK, additional, Freisling, H, additional, Boeing, H, additional, Buckland, G, additional, Schwingshackl, L, additional, Weiderpass, E, additional, Rostgaard-Hansen, AL, additional, Tjønneland, A, additional, Affret, A, additional, Boutron-Ruault, MC, additional, Fagherazzi, G, additional, Katzke, V, additional, Kühn, T, additional, Naska, A, additional, Orfanos, P, additional, Trichopoulou, A, additional, Pala, V, additional, Palli, D, additional, Ricceri, F, additional, Santucci de Magistris, M, additional, Tumino, R, additional, Engeset, D, additional, Enget, T, additional, Skeie, G, additional, Barricarte, A, additional, Bonet, CB, additional, Chirlaque, MD, additional, Amiano, P, additional, Quirós, JR, additional, Sánchez, MJ, additional, Dias, JA, additional, Drake, I, additional, Wennberg, M, additional, Boer, JMA, additional, Ocké, MC, additional, Verschuren, WMM, additional, Lassale, C, additional, Perez-Cornago, A, additional, Riboli, E, additional, Ward, H, additional, and Forslund, H Bertéus, additional
Published: 2016
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38. Modified Mediterranean diet and survival: EPIC-elderly prospective cohort study

Author: TRICHOPOULOU A, ORFANOS P, NORAT T, BUENO DE MESQUITA B, OCKE MC, PEETERS, PH, VAN DER SCHOUW YT, BOEING H, HOFFMANN K, BOFFETTA P, NAGEL G, MASALA G, KROGH V, TUMINO R, VINEIS P, BAMIA C, NASKA A, BENETOU V, FERRARI P, SLIMANI N, PERA G, MARTINEZ GARCIA C, NAVARRO C, RODRIGUEZ BARRANCO M, DORRONSORO M, SPENCER EA, KEY TJ, BINGHAM S, KHAW KT, KESSE E, CLAVEL CHAPELON, F, BOUTRON RUAULT MC, BERGLUND G, WIRFALT E, HALLMANS G, JOHANSSON I, TJONNELAND, A, OLSEN A, OVERVAD K, HUNDBORG HH, RIBOLI E, TRICHOPOULOS D., PANICO, SALVATORE, Trichopoulou, A, Orfanos, P, Norat, T, BUENO DE MESQUITA, B, Ocke, Mc, Peeters, Ph, VAN DER SCHOUW, Yt, Boeing, H, Hoffmann, K, Boffetta, P, Nagel, G, Masala, G, Krogh, V, Panico, Salvatore, Tumino, R, Vineis, P, Bamia, C, Naska, A, Benetou, V, Ferrari, P, Slimani, N, Pera, G, MARTINEZ GARCIA, C, Navarro, C, RODRIGUEZ BARRANCO, M, Dorronsoro, M, Spencer, Ea, Key, Tj, Bingham, S, Khaw, Kt, Kesse, E, Clavel, Chapelon, F, BOUTRON RUAULT, Mc, Berglund, G, Wirfalt, E, Hallmans, G, Johansson, I, Tjonneland, A, Olsen, A, Overvad, K, Hundborg, Hh, Riboli, E, and Trichopoulos, D.
Published: 2005

39. Menarche, menopause, and breast cancer risk: individual participant meta-analysis, including 118 964 women with breast cancer from 117 epidemiological studies

Author: Beral, V, Bull, D, Pirie, K, Reeves, G, Peto, R, Skegg, D, LaVecchia, C, Magnusson, C, Pike, MC, Thomas, D, Hamajima, N, Hirose, K, Tajima, K, Rohan, T, Friedenreich, CM, Calle, EE, Gapstur, SM, Patel, AV, Coates, RJ, Liff, JM, Talamini, R, Chantarakul, N, Koetsawang, S, Rachawat, D, Marcou, Y, Kakouri, E, Duffy, SW, Morabia, A, Schuman, L, Stewart, W, Szklo, M, Coogan, PF, Palmer, JR, Rosenberg, L, Band, P, Coldman, AJ, Gallagher, RP, Hislop, TG, Yang, P, Cummings, SR, Canfell, K, Sitas, F, Chao, P, Lissowska, J, Horn-Ross, PL, John, EM, Kolonel, LM, Nomura, AMY, Ghiasvand, R, Hu, J, Johnson, KC, Mao, Y, Callaghan, K, Crossley, B, Goodill, A, Green, J, Hermon, C, Key, T, Lindgard, I, Liu, B, Collins, R, Doll, R, Bishop, T, Fentiman, IS, De Sanjose, S, Gonzaler, CA, Lee, N, Marchbanks, P, Ory, HW, Peterson, HB, Wingo, P, Ebeling, K, Kunde, D, Nishan, P, Hopper, JL, Eliassen, H, Gajalakshmi, V, Martin, N, Pardthaisong, T, Silpisornkosol, S, Theetranont, C, Boosiri, B, Chutivongse, S, Jimakorn, P, Virutamasen, P, Wongsrichanalai, C, Neugut, A, Santella, R, Baines, CJ, Kreiger, N, Miller, AB, Wall, C, Tjonneland, A, Jorgensen, T, Stahlberg, C, Pedersen, AT, Flesch-Janys, D, Hakansson, N, Cauley, J, Heuch, I, Adami, HO, Persson, I, Weiderpass, E, Chang-Claude, J, Kaaks, R, McCredie, M, Paul, C, Skegg, DCG, Spears, GFS, Iwasaki, M, Tsugane, S, Anderson, G, Daling, JR, Hampton, J, Hutchinson, WB, Li, CI, Malone, K, Mandelson, M, Newcomb, P, Noonan, EA, Ray, RM, Stanford, JL, Tang, MTC, Thomas, DB, Weiss, NS, White, E, Izquierdo, A, Viladiu, P, Fourkala, EO, Jacobs, I, Menon, U, Ryan, A, Cuevas, HR, Ontiveros, P, Palet, A, Salazar, SB, Aristizabal, N, Cuadros, A, Tryggvadottir, L, Tulinius, H, Riboli, E, Andrieu, N, Bachelot, A, Le, MG, Bremond, A, Gairard, B, Lansac, J, Piana, L, Renaud, R, Clavel-Chapelon, F, Fournier, A, Touillaud, M, Mesrine, S, Chabbert-Buffet, N, Boutron-Ruault, MC, Wolk, A, Torres-Mejia, G, Franceschi, S, Romieu, I, Boyle, P, Lubin, F, Modan, B, Ron, E, Wax, Y, Friedman, GD, Hiatt, RA, Levi, F, Kosmelj, K, Primic-Zakelj, M, Ravnihar, B, Stare, J, Ekbom, A, Erlandsson, G, Beeson, WL, Fraser, G, Peto, J, Hanson, RL, Leske, MC, Mahoney, MC, Nasca, PC, Varma, AO, Weinstein, AL, Hartman, ML, Olsson, H, Goldbohm, RA, van den Brandt, PA, Palli, D, Teitelbaum, S, Apelo, RA, Baens, J, de la Cruz, JR, Javier, B, Lacaya, LB, Ngelangel, CA, La Vecchia, C, Negri, E, Marubini, E, Ferraroni, M, Gerber, M, Richardson, S, Segala, C, Gatei, D, Kenya, P, Kungu, A, Mati, JG, Brinton, LA, Freedman, M, Hoover, R, Schairer, C, Ziegler, R, Banks, E, Spirtas, R, Lee, HP, Rookus, MA, van Leeuwen, FE, Schoenberg, JA, Graff-Iversen, S, Selmer, R, Jones, L, McPherson, K, Neil, A, Vessey, M, Yeates, D, Mabuchi, K, Preston, D, Hannaford, P, Kay, C, McCann, SE, Rosero-Bixby, L, Gao, YT, Jin, F, Yuan, J-M, Wei, HY, Yun, T, Zhiheng, C, Berry, G, Booth, JC, Jelihovsky, T, MacLennan, R, Shearman, R, Hadjisavvas, A, Kyriacou, K, Loisidou, M, Zhou, X, Wang, Q-S, Kawai, M, Minami, Y, Tsuji, I, Lund, E, Kumle, M, Stalsberg, H, Shu, XO, Zheng, W, Monninkhof, EM, Onland-Moret, NC, Peeters, PHM, Katsouyanni, K, Trichopoulou, A, Trichopoulos, D, Tzonou, A, Baltzell, KA, Dabancens, A, Martinez, L, Molina, R, Salas, O, Alexander, FE, Anderson, K, Folsom, AR, Gammon, MD, Hulka, BS, Millikan, R, Chilvers, CED, Lumachi, F, Bain, C, Schofield, F, Siskind, V, Rebbeck, TR, Bernstein, LR, Enger, S, Haile, RW, Paganini-Hill, A, Ross, RK, Ursin, G, Wu, AH, Yu, MC, Ewertz, DM, Clarke, EA, Bergkvist, L, Anderson, GL, Gass, M, O'Sullivan, MJ, Kalache, A, Farley, TMM, Holck, S, Meirik, O, Fukao, A, Factors, CGH, Grp, SHNHSIIIR, Epidemiologie, RS: CAPHRI School for Public Health and Primary Care, RS: GROW - School for Oncology and Reproduction, RS: GROW - R1 - Prevention, RS: CAPHRI - R5 - Optimising Patient Care, and Collaborative Group on Hormonal Factors in Breast Cancer
Subjects: Aging, Breast cancer, Risk factors, Menopause, Menarche, cancer, malignancy, Ethnic origin, Disease, 0302 clinical medicine, Breast cancer, Risk Factors, Neoplasms, Receptors, Epidemiology, 80 and over, 030212 general & internal medicine, skin and connective tissue diseases, Aged, 80 and over, Patient, Obstetrics, Reproduction, Smoking, Age Factors, Middle Aged, Reproducibility, 3. Good health, Menopause, Receptors, Estrogen, Oncology, 030220 oncology & carcinogenesis, Menarche, Hormonal therapy, Female, epidemiology, Cancer Type - Breast Cancer, history, Adult, Risk, trends, medicine.medical_specialty, Design, Neoplasms, Hormone-Dependent, Requiring prolonged observation, Hormone Replacement Therapy, Oncology and Carcinogenesis, Breast Neoplasms, and over, Validity, methods, 03 medical and health sciences, Age, Clinical Research, Breast Cancer, medicine, Humans, cancer, Neoplasm Invasiveness, Women, Oncology & Carcinogenesis, Hormone-Dependent, breast, Aged, Gynecology, Collaborative Group on Hormonal Factors in Breast Cancer, therapy, business.industry, Contraception/Reproduction, Research, Estrogens, Etiology - Resources and Infrastructure, medicine.disease, Estrogen, Good Health and Well Being, cessation, Premenopause, Risk factors, Relative risk, Recall, business, malignancy, Meta-Analysis
Abstract: Background Menarche and menopause mark the onset and cessation, respectively, of ovarian activity associated with reproduction, and affect breast cancer risk. Our aim was to assess the strengths of their effects and determine whether they depend on characteristics of the tumours or the affected women.Methods Individual data from 117 epidemiological studies, including 118 964 women with invasive breast cancer and 306 091 without the disease, none of whom had used menopausal hormone therapy, were included in the analyses. We calculated adjusted relative risks (RRs) associated with menarche and menopause for breast cancer overall, and by tumour histology and by oestrogen receptor expression.Findings Breast cancer risk increased by a factor of 1.050 (95% CI 1.044-1.057; p < 0.0001) for every year younger at menarche, and independently by a smaller amount (1.029, 1.025-1.032; p < 0.0001), for every year older at menopause. Premenopausal women had a greater risk of breast cancer than postmenopausal women of an identical age (RR at age 45-54 years 1.43, 1.33-1.52, p < 0.001). All three of these associations were attenuated by increasing adiposity among postmenopausal women, but did not vary materially by women's year of birth, ethnic origin, childbearing history, smoking, alcohol consumption, or hormonal contraceptive use. All three associations were stronger for lobular than for ductal tumours (p < 0.006 for each comparison). The effect of menopause in women of an identical age and trends by age at menopause were stronger for oestrogen receptor-positive disease than for oestrogen receptor-negative disease (p < 0.01 for both comparisons).Interpretation The effects of menarche and menopause on breast cancer risk might not be acting merely by lengthening women's total number of reproductive years. Endogenous ovarian hormones are more relevant for oestrogen receptor-positive disease than for oestrogen receptor-negative disease and for lobular than for ductal tumours.Funding Cancer Research UK.
Published: 2012

40. No association between polymorphisms in CYP2E1, GSTM1, NAT1, NAT2 and the risk of gastric adenocarcinoma in the European prospective investigation into cancer and nutrition

Author: Agudo, A Sala, N Pera, G Capella, G Berenguer, A and Garcia, N Palli, D Boeing, H Del Giudice, G Saieva, C and Carneiro, F Berrino, F Sacerdote, C Tumino, R and Panico, S Berglund, G Siman, H Stenling, R Hallmans, G and Martinez, C Amiano, P Barricarte, A Navarro, C and Quiros, JR Allen, N Key, T Bingham, S Khaw, KT and Linseisen, J Nagel, G Overvad, K Tjonneland, A Olsen, A and Bueno-De-Mesquita, HB Boshuizen, HC Peeters, PH Numans, ME Clavel-Chapelon, F Boutron-Ruault, MC Trichopoulou, A and Lund, E Blaker, H Jenab, M Ferrari, P Norat, T and Riboli, E Gonzalez, CA
Published: 2006

41. Meat, fish, and colorectal cancer risk: The European prospective investigation into cancer and nutrition

Author: Norat, T Bingham, S Ferrari, P Slimani, N Jenab, M and Mazuir, M Overvad, K Olsen, A Tjonneland, A Clavel, F and Boutron-Ruault, MC Kesse, E Boeing, H Bergmann, MM and Nieters, A Linseisen, J Trichopoulou, A Trichopoulos, D and Tountas, Y Berrino, F Palli, D Panico, S Tumino, R and Vineis, P Bueno-De-Mesquita, HB Peeters, PHM Engeset, D and Lund, E Skeie, G Ardanaz, E Gonzalez, C Navarro, C and Quiros, JR Sanchez, MJ Berglund, G Mattisson, I and Hallmans, G Palmqvist, R Day, NE Khaw, KT Key, TJ and San Joaquin, M Hemon, B Saracci, R Kaaks, R Riboli, E
Abstract: Background. Current evidence suggests that high red meat intake is associated with increased colorectal cancer risk. High fish intake may be associated with a decreased risk, but the existing evidence is less convincing. Methods: We prospectively followed 478040 men and women from 10 European countries who were free of cancer at enrollment between 1992 and 1998. Information on diet and lifestyle was collected at baseline. After a mean follow-up of 4.8 years, 1329 incident colorectal cancers were documented. We examined the relationship between intakes of red and processed meat, poultry, and fish and colorectal cancer risk using a proportional hazards model adjusted for age, sex, energy (nonfat and fat sources), height, weight, work-related physical activity, smoking status, dietary fiber and folate, and alcohol consumption, stratified by center. A calibration substudy based on 36994 subjects was used to correct hazard ratios (HRs) and 95% confidence intervals (CIs) for diet measurement errors. All statistical tests were two-sided. Results: Colorectal cancer risk was positively associated with intake of red and processed meat (highest [> 160 g/day] versus lowest [< 20 g/day] intake, HR = 1.35, 95% CI = 0.96 to 1.88; P-trend = .03) and inversely associated with intake of fish (> 80 g/day versus < 10 g/day, HR = 0.69, 95% CI = 0.54 to 0.88; P-trend < .001), but was not related to poultry intake. Correcting for measurement error strengthened the associations between colorectal cancer and red and processed meat intake (per 100-g increase HR = 1.25, 95% CI = 1.09 to 1.41, P-trend = .001 and HR = 1.55, 95% CI = 1.19 to 2.02, P-trend = .001 before and after calibration, respectively) and for fish (per 100 g increase HR = 0.70, 95% CI = 0.57 to 0.87, P-trend < .001 and HR = 0.46, 95% CI = 0.27 to 0.77, P-trend = .003; before and after correction, respectively). In this study population, the absolute risk of development of colorectal cancer within 10 years for a study subject aged 50 years was 1.71% for the highest category of red and processed meat intake and 1.28% for the lowest category of intake and was 1.86% for subjects in the lowest category of fish intake and 1.28% for subjects in the highest category of fish intake. Conclusions: Our data confirm that colorectal cancer risk is positively associated with high consumption of red and processed meat and support an inverse association with fish intake.
Published: 2005

42. Plasma carotenoids as biomarkers of intake of fruits and vegetables: individual-level correlations in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author: Al-Delaimy, WK Ferrari, P Slimani, N Pala, V Johansson, I Nilsson, S Mattisson, I Wirfalt, E Galasso, R and Palli, D Vineis, P Tumino, R Dorronsoro, M Pera, G and Ocke, MC Bueno-de-Mesquita, HB Overvad, K Chirlaque, MAD and Trichopoulou, A Naska, A Tjonneland, A Olsen, A Lund, E and Alsaker, EHR Barricarte, A Kesse, E Boutron-Ruault, MC and Clavel-Chapelon, F Key, TJ Spencer, E Bingham, S and Welch, AA Sanchez-Perez, MJ Nagel, G Linseisen, J and Quiros, JR Peeters, PHM van Gils, CH Boeing, H van Kappel, AL Steghens, JP Riboli, E
Subjects: food and beverages
Abstract: Objective: The aim in this study was to assess the association between individual plasma carotenoid levels (alpha-carotene, beta-carotene, lycopene, beta-cryptoxanthin, lutein, zeaxanthin) and fruit and vegetable intakes recorded by a calibrated food questionnaire (FQ) and 24- h dietary recall records (24HDR) in nine different European countries with diverse populations and widely varying intakes of plant foods. Design: A stratified random subsample of 3089 men and women from nine countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC), who had provided blood samples and dietary and other lifestyle information between 1992 and 2000, were included. Results: beta-Cryptoxanthin was most strongly correlated with total fruits (FQ r = 0.52, 24HDR r = 0.39), lycopene with tomato and tomato products (FQ r = 0.38, 24HDR r = 0.25), and alpha-carotene with intake of root vegetables (r = 0.39) and of total carrots (r = 0.38) for FQ only. Based on diet measured by FQ and adjusting for possible confounding by body mass index (BMI), age, gender, smoking status, alcohol intake, and energy intake, the strongest predictors of individual plasma carotenoid levels were fruits (R-partial(2) = 17.2%) for beta-cryptoxanthin, total carrots (R-partial(2) = 13.4%) and root vegetables (R-partial(2) = 13.3%) for alpha-carotene, and tomato products (R-partial(2) = 13.8%) for lycopene. For 24HDR, the highest R-partial(2) was for fruits in relation to beta-cryptoxanthin (7.9%). Conclusions: Intakes of specific fruits and vegetables as measured by food questionnaires are good predictors of certain individual plasma carotenoid levels in our multicentre European study. At individual subject levels, FQ measurements of fruits, root vegetables and carrots, and tomato products are, respectively, good predictors of beta-cryptoxanthin, alpha-carotene, and lycopene in plasma.
Published: 2005

43. Dietary patterns among older Europeans: the EPIC-Elderly study

Author: Bamia, C Orfanos, P Ferrari, P Overvad, K Hundborg, HH and Tjonneland, A Olsen, A Kesse, E Boutron-Ruault, MC and Clavel-Chapelon, F Nagel, G Boffetta, P Boeing, H and Hoffmann, K Trichopoulos, D Baibas, N Psaltopoulou, T and Norat, T Slimani, N Palli, D Krogh, V Panico, S and Tumino, R Sacerdote, C Bueno-de-Mesquita, HB Ocke, MC and Peeters, PH van Rossum, CT Quiros, JR Sanchez, MJ and Navarro, C Barricarte, A Dorronsoro, M Berglund, G and Wirfalt, E Hallmans, G Johansson, I Bingham, S Khaw, KT and Spencer, EA Roddam, AW Riboli, E Trichopoulou, A
Subjects: endocrine system, food and beverages
Abstract: Overall dietary patterns have been associated with health and longevity. We used principal component (PC) and cluster analyses to identify the prevailing dietary patterns of 99 744 participants, aged 60 years or older, living in nine European countries and participating in the European Prospective Investigation into Cancer and Nutrition (EPIC-Elderly cohort) and to examine their socio-demographic and lifestyle correlates. Two PC were identified: PC1 reflects a ‘vegetable-based’ diet with an emphasis on foods of plant origin, rice, pasta and other grain rather than on margarine, potatoes and non-alcoholic beverages. PC2 indicates a ‘sweet- and fat-dominated’ diet with a preference for sweets, added fat and dairy products but not meat, alcohol, bread and eggs. PC1 was associated with a younger age, a higher level of education, physical activity, a higher BMI, a lower waist:hip ratio and never and past smoking. PC2 was associated with older age, less education, never having smoked, a lower BMI and waist:hip ratio and lower levels of physical activity. Elderly individuals in southern Europe scored positively on PC1 and about zero on PC2, whereas the elderly in northern Europe scored negatively on PC1 and variably on PC2. The results of cluster analysis were compatible with the indicated dietary patterns. ‘Vegetable-based’ and a ‘sweet- and fat-dominated’ diets are prevalent among the elderly across Europe, and there is a north-south gradient regarding their dietary choices. Our study contributes to the identification of groups of elderly who are likely to have different prospects for long-term disease occurrence and survival.
Published: 2005

44. Plasma carotenoids as biomarkers of intake of fruits and vegetables: ecological-level correlations in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author: Al-Delaimy, WK Slimani, N Ferrari, P Key, T Spencer, E and Johansson, I Johansson, G Mattisson, I Wirfalt, E and Sieri, S Agudo, A Celentano, E Palli, D Sacerdote, C and Tumino, R Dorronsoro, M Ocke, MC Bueno-De-Mesquita, HB and Overvad, K Chirlaque, MD Trichopoulou, A Naska, A and Tjonneland, A Olsen, A Lund, E Skeie, G Ardanaz, E and Kesse, E Boutron-Ruault, MC Clavel-Chapelon, F Bingham, S and Welch, AA Martinez-Garcia, C Nagel, G Linseisen, J and Quiros, JR Peeters, PHM van Gils, CH Boeing, H van Kappel, AL Steghens, JP Riboli, E
Subjects: food and beverages
Abstract: Objective: The aim of this study was to assess the ability of a single 24-h dietary recall (24HDR) and food questionnaires (FQ) to predict plasma carotenoid levels at the ecological level by assessing the relationship between mean plasma carotenoid levels and mean intake of fruit and vegetables measured by 24HDR and FQ across 16 European regions. Design: A random subsample of 3089 subjects was included, stratified by age and gender. They provided blood samples and dietary information between 1992 and 2000 as part of the European Prospective Investigation into Cancer and Nutrition. Results: Using Spearman’s correlation coefficients, the correlations between mean regional 24HDR fruit and vegetable variables and corresponding mean plasma carotenoid levels were generally higher than the correlations using FQ means. The highest correlation was between the 24HDR citrus fruit variable and beta-cryptoxanthin (r = 0.90). For 24HDR, total fruits and vegetables were highly correlated with lutein, zeaxanthin, and beta-cryptoxanthin (r = 0.83-0.87), while vegetables were more closely related with lutein (r = 0.69) and zeaxanthin (r = 0.68), and fruits correlated with zeaxanthin (r = 0.87) and beta-cryptoxanthin (r = 0.84). Root vegetables (r = 0.81) and total carrots (r = 0.71) were well correlated with alpha-carotene. In the multivariate models adjusting for age, body mass index, and season, and using observations of means stratified by sex and region, the association was generally higher for 24HDR compared to FQ. Conclusion: Mean regional intakes of fruits and vegetables in several European countries were closely correlated with corresponding mean plasma levels of individual carotenoids. Fruits and vegetables measured by 24HDR were generally better able to predict plasma carotenoids at the ecological level.
Published: 2005

45. Fruit and vegetable consumption and risk of epithelial ovarian cancer: The European prospective investigation into cancer and nutrition

Author: Schulz, M Lahmann, PH Boeing, H Hoffmann, K Allen, N and Key, TJA Bingham, S Wirfalt, E Berglund, G Lundin, E and Hallmans, G Lukanova, A Garcia, CM Gonzalez, CA Tormo, MJ Quiros, JR Ardanaz, E Larranaga, N Lund, E Gram, IT Skeie, G Peeters, PHM van Gils, CH Bueno-de-Mesquita, HB Buchner, FL Pasanisi, P Galasso, R Palli, D and Tumino, R Vineis, P Trichopoulou, A Kalapothaki, V and Trichopoulos, D Chang-Claude, J Linseisen, J Boutron-Ruault, MC Touillaud, M Clavel-Chapelon, F Olsen, A Tjonneland, A Overvad, K Tetsche, M Jenab, M Norat, T Kaaks, R and Riboli, E
Subjects: food and beverages
Abstract: Objective: The association between consumption of fruit and vegetables and risk of ovarian cancer is still unclear from a prospective point of view. Methods: Female participants (n = 325,640) of the European Prospective Investigation into Cancer and Nutrition study, free of any cancer at baseline, were followed on average for 6.3 years to develop ovarian cancer. During 2,049,346 person-years, 581 verified cases of primary, invasive epithelial ovarian cancer were accrued. Consumption of fruits and vegetables as well as subgroups of vegetables, estimated from validated dietary questionnaires and calibrated thereafter, was related to ovarian cancer incidence in multivariable hazard regression models. Histologic subtype specific analyses were done. Results: Total intake of fruit and vegetables, separately or combined, as well as subgroups of vegetables (fruiting, root, leafy vegetables, cabbages) was unrelated to risk of ovarian cancer. A high intake of garlic/onion vegetables was associated with a borderline significant reduced risk of this cancer. The examination by histologic subtype indicated some differential effects of fruit and vegetable intake on ovarian cancer risk. Conclusion: Overall, a high intake of fruits and vegetables did not seem to protect from ovarian cancer. Garlic/onion vegetables may exert a beneficial effect. The study of the histologic subtype of the tumor warrants further investigation.
Published: 2005

46. Consumption of fish and meats and risk of hepatocellular carcinoma : the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author: Fedirko, V, Trichopolou, A, Bamia, C, Duarte-Salles, T, Trepo, E, Aleksandrova, K, Nöthlings, U, Lukanova, A, Lagiou, P, Boffetta, P, Trichopoulos, D, Katzke, VA, Overvad, K, Tjønneland, A, Hansen, L, Boutron-Ruault, MC, Fagherazzi, G, Bastide, N, Panico, S, Grioni, S, Vineis, P, Palli, D, Tumino, R, Bueno-de-Mesquita, HB, Peeters, PH, Skeie, G, Engeset, D, Parr, CL, Jakszyn, P, Sánchez, MJ, Barricarte, A, Amiano, P, Chirlaque, M, Quirós, JR, Sund, Malin, Werner, Mårten, Sonestedt, E, Ericson, U, Key, TJ, Khaw, KT, Ferrari, P, Romieu, I, Riboli, E, Jenab, M, Fedirko, V, Trichopolou, A, Bamia, C, Duarte-Salles, T, Trepo, E, Aleksandrova, K, Nöthlings, U, Lukanova, A, Lagiou, P, Boffetta, P, Trichopoulos, D, Katzke, VA, Overvad, K, Tjønneland, A, Hansen, L, Boutron-Ruault, MC, Fagherazzi, G, Bastide, N, Panico, S, Grioni, S, Vineis, P, Palli, D, Tumino, R, Bueno-de-Mesquita, HB, Peeters, PH, Skeie, G, Engeset, D, Parr, CL, Jakszyn, P, Sánchez, MJ, Barricarte, A, Amiano, P, Chirlaque, M, Quirós, JR, Sund, Malin, Werner, Mårten, Sonestedt, E, Ericson, U, Key, TJ, Khaw, KT, Ferrari, P, Romieu, I, Riboli, E, and Jenab, M
Abstract: BACKGROUND: While higher intake of fish and lower consumption of red/processed meats have been suggested to play a protective role in the etiology of several cancers, prospective evidence for hepatocellular carcinoma (HCC) is limited, particularly in Western European populations. METHODS: The associations of fish and meats with HCC risk were analyzed in the EPIC cohort. Between 1992 and 2010, 191 incident HCC were identified among 477 206 participants. Baseline diet was assessed using validated dietary questionnaires. A single 24-h diet recall from a cohort subsample was used for calibration. Multivariable proportional hazard regression was utilized to estimate hazard ratios (HR) and 95% confidence intervals (CI). In a nested case-control subset (HCC = 122), HBV/HCV status and liver function biomarkers were measured. RESULTS: HCC risk was inversely associated with intake of total fish (per 20 g/day increase, HR = 0.83, 95% CI 0.74-0.95 and HR = 0.80, 95% CI 0.69-0.97 before and after calibration, respectively). This inverse association was also suggested after adjusting for HBV/HCV status and liver function score (per 20-g/day increase, RR = 0.86, 95% CI 0.66-1.11 and RR = 0.74, 95% CI 0.50-1.09, respectively) in a nested case-control subset. Intakes of total meats or subgroups of red/processed meats, and poultry were not associated with HCC risk. CONCLUSIONS: In this large European cohort, total fish intake is associated with lower HCC risk.
Published: 2013
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47. Variety in vegetable and fruit consumption and the risk of gastric and esophageal cancer in the European Prospective investigation into cancer and nutrition

Author: Jeurnink, SM, Büchner, FL, Bueno-de-Mesquita, HB, Siersema, PD, Boshuizen, HC, Numans, ME, Dahm, CC, Overvad, K, Tjønneland, A, Roswall, N, Clavel-Chapelon, F, Boutron-Ruault, MC, Morois, S, Kaaks, R, Teucher, B, Boeing, H, Buijsse, B, Trichopoulou, A, Benetou, V, Zylis, D, Palli, D, Sieri, S, Vineis, P, Tumino, R, Panico, S, Ocké, MC, Peeters, PHM, Skeie, G, Brustad, M, Lund, E, Sánchez-Cantalejo, E, Navarro, C, Amiano, P, Ardanaz, E, Quirós, J Ramón, Hallmans, Göran, Johansson, I, Lindkvist, B, Regnér, S, Khaw, KT, Wareham, N, Key, TJ, Slimani, N, Norat, T, Vergnaud, AC, Romaguera, D, Gonzalez, CA, Jeurnink, SM, Büchner, FL, Bueno-de-Mesquita, HB, Siersema, PD, Boshuizen, HC, Numans, ME, Dahm, CC, Overvad, K, Tjønneland, A, Roswall, N, Clavel-Chapelon, F, Boutron-Ruault, MC, Morois, S, Kaaks, R, Teucher, B, Boeing, H, Buijsse, B, Trichopoulou, A, Benetou, V, Zylis, D, Palli, D, Sieri, S, Vineis, P, Tumino, R, Panico, S, Ocké, MC, Peeters, PHM, Skeie, G, Brustad, M, Lund, E, Sánchez-Cantalejo, E, Navarro, C, Amiano, P, Ardanaz, E, Quirós, J Ramón, Hallmans, Göran, Johansson, I, Lindkvist, B, Regnér, S, Khaw, KT, Wareham, N, Key, TJ, Slimani, N, Norat, T, Vergnaud, AC, Romaguera, D, and Gonzalez, CA
Abstract: BACKGROUND: Diets high in vegetables and fruits have been suggested to be inversely associated with risk of gastric cancer. However, the evidence of the effect of variety of consumption is limited. We therefore investigated whether consumption of a variety of vegetables and fruit is associated with gastric and esophageal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. METHODS: Data on food consumption and follow-up on cancer incidence was available for 452,269 participants from 10 European countries. After a mean follow-up of 8.4 years, 475 cases of gastric and esophageal adenocarcinomas (180 non-cardia, 185 cardia, gastric esophageal junction and esophagus, 110 not specified) and 98 esophageal squamous cell carcinomas were observed. Diet Diversity Scores (DDSs) were used to quantify the variety in vegetable and fruit consumption. We used multivariable Cox proportional hazard models to calculate risk ratios. RESULTS: Independent from quantity of consumption, variety in the consumption of vegetables and fruit combined and of fruit consumption alone were statistically significantly inversely associated with the risk of esophageal squamous cell carcinoma (continuous HR per 2 products increment 0.88; 95%CI 0.79-0.97 and 0.76; 95%CI 0.62-0.94, respectively) with the latter particularly seen in ever smokers. Variety in vegetable and/or fruit consumption was not associated with risk of gastric and esophageal adenocarcinomas. CONCLUSION: Independent from quantity of consumption, more variety in vegetable and fruit consumption combined and in fruit consumption alone may decrease the risk of esophageal squamous cell carcinoma. However, residual confounding by lifestyle factors can not be excluded. © 2012 Wiley-Liss, Inc.
Published: 2012
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48. Concentrations of IGF-I and IGFBP-3 and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition

Author: Rohrmann, S, Grote, VA, Becker, S, Rinaldi, S, Tjonneland, A, Roswall, N, Gronbaek, H, Overvad, K, Boutron-Ruault, MC, Clavel-Chapelon, F, Racine, A, Teucher, B, Boeing, H, Drogan, D, Dilis, V, Lagiou, P, Trichopoulou, A, Palli, D, Tagliabue, G, Tumino, R, Vineis, P, Mattiello, A, Rodriguez, L, Duell, EJ, Molina-Montes, E, Dorronsoro, M, Huerta, J-M, Ardanaz, E, Jeurnink, S, Peeters, PHM, Lindkvist, B, Johansen, D, Sund, Malin, Ye, W, Khaw, K-T, Wareham, NJ, Allen, NE, Crowe, FL, Fedirko, V, Jenab, M, Michaud, DS, Norat, T, Riboli, E, Bueno-de-Mesquita, HB, Kaaks, R, Rohrmann, S, Grote, VA, Becker, S, Rinaldi, S, Tjonneland, A, Roswall, N, Gronbaek, H, Overvad, K, Boutron-Ruault, MC, Clavel-Chapelon, F, Racine, A, Teucher, B, Boeing, H, Drogan, D, Dilis, V, Lagiou, P, Trichopoulou, A, Palli, D, Tagliabue, G, Tumino, R, Vineis, P, Mattiello, A, Rodriguez, L, Duell, EJ, Molina-Montes, E, Dorronsoro, M, Huerta, J-M, Ardanaz, E, Jeurnink, S, Peeters, PHM, Lindkvist, B, Johansen, D, Sund, Malin, Ye, W, Khaw, K-T, Wareham, NJ, Allen, NE, Crowe, FL, Fedirko, V, Jenab, M, Michaud, DS, Norat, T, Riboli, E, Bueno-de-Mesquita, HB, and Kaaks, R
Abstract: BACKGROUND: Insulin-like growth factors (IGFs) and their binding proteins (BPs) regulate cell differentiation, proliferation and apoptosis, and may have a role in the aetiology of various cancers. Information on their role in pancreatic cancer is limited and was examined here in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition. METHODS: Serum concentrations of IGF-I and IGFBP-3 were measured using enzyme-linked immunosorbent assays in 422 cases and 422 controls matched on age, sex, study centre, recruitment date, and time since last meal. Conditional logistic regression was used to compute odds ratios (OR) and 95% confidence intervals (CI) adjusted for confounding variables. RESULTS: Neither circulating levels of IGF-I (OR = 1.21, 95% CI 0.75-1.93 for top vs bottom quartile, P-trend 0.301), IGFBP-3 (OR = 1.00, 95% CI 0.66-1.51, P-trend 0.79), nor the molar IGF-I/IGFBP-3 ratio, an indicator of free IGF-I level (OR = 1.22, 95% CI 0.75-1.97, P-trend 0.27), were statistically significantly associated with the risk of pancreatic cancer. In a cross-classification, however, a high concentration of IGF-I with concurrently low levels of IGFBP-3 was related to an increased risk of pancreatic cancer (OR = 1.72, 95% CI 1.05-2.83; P-interaction = 0.154). CONCLUSION: On the basis of these results, circulating levels of components of the IGF axis do not appear to be the risk factors for pancreatic cancer. However, on the basis of the results of a subanalysis, it cannot be excluded that a relatively large amount of IGF-1 together with very low levels of IGFBP-3 might still be associated with an increase in pancreatic cancer risk. British Journal of Cancer (2012) 106, 1004-1010. doi:10.1038/bjc.2012.19 www.bjcancer.com Published online 7 February 2012 (C) 2012 Cancer Research UK
Published: 2012
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49. Inflammation marker and risk of pancreatic cancer : a nested case-control study within the EPIC cohort

Author: Grote, VA, Kaaks, R, Nieters, A, Tjonneland, A, Halkjaer, J, Overvad, K, Nielsen, MR Skjelbo, Boutron-Ruault, MC, Clavel-Chapelon, F, Racine, A, Teucher, B, Becker, S, Pischon, T, Boeing, H, Trichopoulou, A, Cassapa, C, Stratigakou, V, Palli, D, Krogh, V, Tumino, R, Vineis, P, Panico, S, Rodriguez, L, Duell, EJ, Sanchez, M-J, Dorronsoro, M, Navarro, C, Gurrea, AB, Siersema, PD, Peeters, PHM, Ye, W, Sund, Malin, Lindkvist, B, Johansen, D, Khaw, K-T, Wareham, N, Allen, NE, Travis, RC, Fedirko, V, Jenab, M, Michaud, DS, Chuang, S-C, Romaguera, D, Bueno-de-Mesquita, HB, Rohrmann, S, Grote, VA, Kaaks, R, Nieters, A, Tjonneland, A, Halkjaer, J, Overvad, K, Nielsen, MR Skjelbo, Boutron-Ruault, MC, Clavel-Chapelon, F, Racine, A, Teucher, B, Becker, S, Pischon, T, Boeing, H, Trichopoulou, A, Cassapa, C, Stratigakou, V, Palli, D, Krogh, V, Tumino, R, Vineis, P, Panico, S, Rodriguez, L, Duell, EJ, Sanchez, M-J, Dorronsoro, M, Navarro, C, Gurrea, AB, Siersema, PD, Peeters, PHM, Ye, W, Sund, Malin, Lindkvist, B, Johansen, D, Khaw, K-T, Wareham, N, Allen, NE, Travis, RC, Fedirko, V, Jenab, M, Michaud, DS, Chuang, S-C, Romaguera, D, Bueno-de-Mesquita, HB, and Rohrmann, S
Abstract: BACKGROUND: Established risk factors for pancreatic cancer include smoking, long-standing diabetes, high body fatness, and chronic pancreatitis, all of which can be characterised by aspects of inflammatory processes. However, prospective studies investigating the relation between inflammatory markers and pancreatic cancer risk are scarce. METHODS: We conducted a nested case-control study within the European Prospective Investigation into Cancer and Nutrition, measuring prediagnostic blood levels of C-reactive protein (CRP), interleukin-6 (IL-6), and soluble receptors of tumour necrosis factor-a (sTNF-R1, R2) in 455 pancreatic cancer cases and 455 matched controls. Odds ratios (ORs) were estimated using conditional logistic regression models. RESULTS: None of the inflammatory markers were significantly associated with risk of pancreatic cancer overall, although a borderline significant association was observed for higher circulating sTNF-R2 (crude OR = 1.52 (95% confidence interval (CI) 0.97-2.39), highest vs lowest quartile). In women, however, higher sTNF-R1 levels were significantly associated with risk of pancreatic cancer (crude OR = 1.97 (95% CI 1.02-3.79)). For sTNF-R2, risk associations seemed to be stronger for diabetic individuals and those with a higher BMI. CONCLUSION: Prospectively, CRP and IL-6 do not seem to have a role in our study with respect to risk of pancreatic cancer, whereas sTNF-R1 seemed to be a risk factor in women and sTNF-R2 might be a mediator in the risk relationship between overweight and diabetes with pancreatic cancer. Further large prospective studies are needed to clarify the role of proinflammatory proteins and cytokines in the pathogenesis of exocrine pancreatic cancer. British Journal of Cancer (2012) 106, 1866-1874. doi:10.1038/bjc.2012.172 www.bjcancer.com Published online 26 April 2012 (C) 2012 Cancer Research UK
Published: 2012
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50. Menstrual and reproductive factors, exogenous hormone use, and gastric cancer risk in a cohort of women from the European Prospective Investigation Into Cancer and Nutrition

Author: Duell, Eric J, Travier, Noémie, Lujan-Barroso, Leila, Boutron-Ruault, MC, Clavel-Chapelon, F, Palli, Domenico, Krogh, Vittorio, Mattiello, Amalia, Tumino, Rosario, Sacerdote, Carlotta, Rodriguez, Laudina, Sanchez-Cantalejo, Emilio, Navarro, Carmen, Barricarte, Aurelio, Dorronsoro, Miren, Khaw, Kay-Tee, Wareham, Nicholas, Allen, Naomi E, Tsilidis, Konstantinos K, Bueno-de-Mesquita, H Bas, Jeurnink, Suzanne M, Numans, ME, Peeters, Petra HM, Lagiou, Pagona, Valanou, Elisabeth, Trichopoulou, Antonia, Kaaks, Rudolf, Lukanova-McGregor, Annekatrin, Bergman, Manuela M, Boeing, Heiner, Manjer, Jonas, Lindkvist, Björn, Stenling, Roger, Hallmans, Göran, Dahm, Christina C, Overvad, Kim, Olsen, Anja, Tjonneland, Anne, Bakken, Kjersti, Lund, Eiliv, Jenab, Mazda, McCormack, Valerie, Rinaldi, Sabina, Michaud, Dominique, Mouw, Traci, Nesi, Gabriella, Carneiro, Fatima, Riboli, Elio, González, Carlos A, Duell, Eric J, Travier, Noémie, Lujan-Barroso, Leila, Boutron-Ruault, MC, Clavel-Chapelon, F, Palli, Domenico, Krogh, Vittorio, Mattiello, Amalia, Tumino, Rosario, Sacerdote, Carlotta, Rodriguez, Laudina, Sanchez-Cantalejo, Emilio, Navarro, Carmen, Barricarte, Aurelio, Dorronsoro, Miren, Khaw, Kay-Tee, Wareham, Nicholas, Allen, Naomi E, Tsilidis, Konstantinos K, Bueno-de-Mesquita, H Bas, Jeurnink, Suzanne M, Numans, ME, Peeters, Petra HM, Lagiou, Pagona, Valanou, Elisabeth, Trichopoulou, Antonia, Kaaks, Rudolf, Lukanova-McGregor, Annekatrin, Bergman, Manuela M, Boeing, Heiner, Manjer, Jonas, Lindkvist, Björn, Stenling, Roger, Hallmans, Göran, Dahm, Christina C, Overvad, Kim, Olsen, Anja, Tjonneland, Anne, Bakken, Kjersti, Lund, Eiliv, Jenab, Mazda, McCormack, Valerie, Rinaldi, Sabina, Michaud, Dominique, Mouw, Traci, Nesi, Gabriella, Carneiro, Fatima, Riboli, Elio, and González, Carlos A
Abstract: The worldwide incidence of gastric adenocarcinoma (GC) is lower in women than in men. Furthermore, cancer patients treated with estrogens have been reported to have a lower subsequent risk of GC. The authors conducted a prospective analysis of menstrual and reproductive factors, exogenous hormone use, and GC in 335,216 women from the European Prospective Investigation Into Cancer and Nutrition, a cohort study of individuals aged 35-70 years from 10 European countries. After a mean follow-up of 8.7 years (through 2004), 181 women for whom complete exposure data were available developed GC. Adjusted hazard ratios and 95% confidence intervals were estimated using Cox proportional hazards models. All statistical tests were 2-sided. Women who had ovariectomy had a 79% increased risk of GC (based on 25 cases) compared with women who did not (hazard ratio = 1.79, 95% confidence interval: 1.15, 2.78). Total cumulative years of menstrual cycling was inversely associated with GC risk (fifth vs. first quintile: hazard ratio = 0.55, 95% confidence interval: 0.31, 0.98; P(trend) = 0.06). No other reproductive factors analyzed were associated with risk of GC. The results of this analysis provide some support for the hypothesis that endogenous ovarian sex hormones lower GC incidence in women.
Published: 2010
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