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Abdominal obesity, weight gain during adulthood and risk of liver and biliary tract cancer in a European cohort
- Source :
- International Journal of Cancer, International Journal of Cancer, Wiley, 2013, 132 (3), pp.645-57. ⟨10.1002/ijc.27645⟩, Schlesinger, S, Aleksandrova, K, Pischon, T, Fedirko, V, Jenab, M, Trepo, E, Boffetta, P, Dahm, C C, Overvad, K, Tjønneland, A, Halkjær, J, Fagherazzi, G, Boutron-Ruault, M-C, Carbonnel, F, Kaaks, R, Lukanova, A, Boeing, H, Trichopoulou, A, Bamia, C, Lagiou, P, Palli, D, Grioni, S, Panico, S, Tumino, R, Vineis, P, Bueno-de-Mesquita, H B, van den Berg, S, Peeters, P H M, Braaten, T, Weiderpass, E, Quirós, J R, Travier, N, Sánchez, M-J, Navarro, C, Barricarte, A, Dorronsoro, M, Lindkvist, B, Regner, S, Werner, M, Sund, M, Khaw, K-T, Wareham, N, Travis, R C, Norat, T, Wark, P A, Riboli, E & Nöthlings, U 2013, ' Abdominal obesity, weight gain during adulthood and risk of liver and biliary tract cancer in a European cohort ', International Journal of Cancer, vol. 132, no. 3, pp. 645-57 . https://doi.org/10.1002/ijc.27645, Schlesinger, S, Aleksandrova, K, Pischon, T, Fedirko, V, Jenab, M, Trepo, E, Boffetta, P, Dahm, C C, Overvad, K, Tjønneland, A, Halkjaer, J, Fagherazzi, G, Boutron-Ruault, M-C, Carbonnel, F, Kaaks, R, Lukanova, A, Boeing, H, Trichopoulou, A, Bamia, C, Lagiou, P, Palli, D, Grioni, S, Panico, S, Tumino, R, Vineis, P, Bas Bueno-de-Mesquita, H, van den Berg, S, Peeters, P H M, Braaten, T, Weiderpass, E, Quirós, J R, Travier, N, Sánchez, M-J, Navarro, C, Barricarte, A, Dorronsoro, M, Lindkvist, B, Regner, S, Werner, M, Sund, M, Khaw, K-T, Wareham, N, Travis, R C, Norat, T, Wark, P A, Riboli, E & Nöthlings, U 2013, ' Abdominal Obesity, Weight Gain during Adulthood and Risk of Liver and Biliary Tract Cancer in a European Cohort ', International Journal of Cancer, vol. 132, no. 3, pp. 645-57 . https://doi.org/10.1002/ijc.27645
- Publication Year :
- 2013
-
Abstract
- Schlesinger, Sabrina Aleksandrova, Krasimira Pischon, Tobias Fedirko, Veronika Jenab, Mazda Trepo, Elisabeth Boffetta, Paolo Dahm, Christina C Overvad, Kim Tjonneland, Anne Halkjaer, Jytte Fagherazzi, Guy Boutron-Ruault, Marie-Christine Carbonnel, Franck Kaaks, Rudolf Lukanova, Annekatrin Boeing, Heiner Trichopoulou, Antonia Bamia, Christina Lagiou, Pagona Palli, Domenico Grioni, Sara Panico, Salvatore Tumino, Rosario Vineis, Paolo Bueno-de-Mesquita, H B van den Berg, Saskia Peeters, Petra H M Braaten, Tonje Weiderpass, Elisabete Quiros, J Ramon Travier, Noemie Sanchez, Maria-Jose Navarro, Carmen Barricarte, Aurelio Dorronsoro, Miren Lindkvist, Bjorn Regner, Sara Werner, Marten Sund, Malin Khaw, Kay-Tee Wareham, Nicholas Travis, Ruth C Norat, Teresa Wark, Petra A Riboli, Elio Nothlings, Ute eng 11692/Cancer Research UK/United Kingdom G0401527/Medical Research Council/United Kingdom G1000143/Medical Research Council/United Kingdom MC_U106179471/Medical Research Council/United Kingdom British Heart Foundation/United Kingdom Cancer Research UK/United Kingdom Department of Health/United Kingdom Medical Research Council/United Kingdom Wellcome Trust/United Kingdom Research Support, Non-U.S. Gov't 2012/05/24 06:00 Int J Cancer. 2013 Feb 1;132(3):645-57. doi: 10.1002/ijc.27645. Epub 2012 Jun 13.; International audience; General obesity has been positively associated with risk of liver and probably with biliary tract cancer, but little is known about abdominal obesity or weight gain during adulthood. We used multivariable Cox proportional hazard models to investigate associations between weight, body mass index, waist and hip circumference, waist-to-hip and waist-to-height ratio (WHtR), weight change during adulthood and risk of hepatocellular carcinoma (HCC), intrahepatic (IBDC) and extrahepatic bile duct system cancer [EBDSC including gallbladder cancer (GBC)] among 359,525 men and women in the European Prospective Investigation into Cancer and Nutrition study. Hepatitis B and C virus status was measured in a nested case-control subset. During a mean follow-up of 8.6 years, 177 cases of HCC, 58 cases of IBDC and 210 cases of EBDSC, including 76 cases of GBC, occurred. All anthropometric measures were positively associated with risk of HCC and GBC. WHtR showed the strongest association with HCC [relative risk (RR) comparing extreme tertiles 3.51, 95% confidence interval (95% CI): 2.09-5.87; p(trend) < 0.0001] and with GBC (RR: 1.56, 95% CI: 1.12-2.16 for an increment of one unit in WHtR). Weight gain during adulthood was also positively associated with HCC when comparing extreme tertiles (RR: 2.48, 95% CI: 1.49-4.13
- Subjects :
- Male
Cancer Research
obesity
Weight Gain
Gastroenterology
Body Mass Index
Hepatocellular/*epidemiology/etiology Case-Control Studies Europe/epidemiology Female Hepatitis B/epidemiology Hepatitis C/epidemiology Humans Liver Neoplasms/*epidemiology/etiology Male Middle Aged Nutritional Status Obesity
Biliary Tract Neoplasms/*epidemiology/etiology Body Composition Body Mass Index Body Weight Carcinoma
hepatocellular carcinoma (HCC)
0302 clinical medicine
Waist–hip ratio
intrahepatic (IBDC)
Prospective Studies
Prospective cohort study
Abdominal/*epidemiology Proportional Hazards Models Prospective Studies Waist-Hip Ratio *Weight Gain
Abdominal obesity
extrahepatic bile duct system cancer
2. Zero hunger
Liver Neoplasms
weight gain
Middle Aged
Hepatitis B
Hepatitis C
3. Good health
European Prospective Investigation into Cancer and Nutrition
Europe
Biliary Tract Neoplasms
Oncology
030220 oncology & carcinogenesis
Obesity, Abdominal
Body Composition
030211 gastroenterology & hepatology
Female
medicine.symptom
medicine.medical_specialty
Carcinoma, Hepatocellular
adulthood
liver and biliary tract cancer
Nutritional Status
abdominal obesity
03 medical and health sciences
Internal medicine
medicine
Humans
Gallbladder cancer
Proportional Hazards Models
business.industry
Waist-Hip Ratio
Weight change
Body Weight
medicine.disease
Endocrinology
Relative risk
Case-Control Studies
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
business
Body mass index
Subjects
Details
- Language :
- English
- ISSN :
- 00207136 and 10970215
- Database :
- OpenAIRE
- Journal :
- International Journal of Cancer, International Journal of Cancer, Wiley, 2013, 132 (3), pp.645-57. ⟨10.1002/ijc.27645⟩, Schlesinger, S, Aleksandrova, K, Pischon, T, Fedirko, V, Jenab, M, Trepo, E, Boffetta, P, Dahm, C C, Overvad, K, Tjønneland, A, Halkjær, J, Fagherazzi, G, Boutron-Ruault, M-C, Carbonnel, F, Kaaks, R, Lukanova, A, Boeing, H, Trichopoulou, A, Bamia, C, Lagiou, P, Palli, D, Grioni, S, Panico, S, Tumino, R, Vineis, P, Bueno-de-Mesquita, H B, van den Berg, S, Peeters, P H M, Braaten, T, Weiderpass, E, Quirós, J R, Travier, N, Sánchez, M-J, Navarro, C, Barricarte, A, Dorronsoro, M, Lindkvist, B, Regner, S, Werner, M, Sund, M, Khaw, K-T, Wareham, N, Travis, R C, Norat, T, Wark, P A, Riboli, E & Nöthlings, U 2013, ' Abdominal obesity, weight gain during adulthood and risk of liver and biliary tract cancer in a European cohort ', International Journal of Cancer, vol. 132, no. 3, pp. 645-57 . https://doi.org/10.1002/ijc.27645, Schlesinger, S, Aleksandrova, K, Pischon, T, Fedirko, V, Jenab, M, Trepo, E, Boffetta, P, Dahm, C C, Overvad, K, Tjønneland, A, Halkjaer, J, Fagherazzi, G, Boutron-Ruault, M-C, Carbonnel, F, Kaaks, R, Lukanova, A, Boeing, H, Trichopoulou, A, Bamia, C, Lagiou, P, Palli, D, Grioni, S, Panico, S, Tumino, R, Vineis, P, Bas Bueno-de-Mesquita, H, van den Berg, S, Peeters, P H M, Braaten, T, Weiderpass, E, Quirós, J R, Travier, N, Sánchez, M-J, Navarro, C, Barricarte, A, Dorronsoro, M, Lindkvist, B, Regner, S, Werner, M, Sund, M, Khaw, K-T, Wareham, N, Travis, R C, Norat, T, Wark, P A, Riboli, E & Nöthlings, U 2013, ' Abdominal Obesity, Weight Gain during Adulthood and Risk of Liver and Biliary Tract Cancer in a European Cohort ', International Journal of Cancer, vol. 132, no. 3, pp. 645-57 . https://doi.org/10.1002/ijc.27645
- Accession number :
- edsair.doi.dedup.....6511c79831996bc0a98eb882be57c7e7