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Introduction. – Vasculitis is a rare complication of antithyroid drugs reported with propylthiouracil, carbimazol, methimazol and we discribe the first case with benzylthyouracil. Renal involvement during thyroid auto-immune diseases and during vasculitis as complication of antithyroid drugs will be discussed.Exegesis. – We present a case study of 28-year-old female patient with Graves'' disease diagnosed in 1996 and treated by benzylthiouracil for 2 years. The thyroid function was poorly controlled, so surgical treatment was indicated in May 1998. One month later, she developed vasculitis with pulmonary and renal involvement. Her renal function deteriorated rapidly. On admission, the additional laboratory findings showed hematuria, proteinuria of 1,44 g/day and serum creatinine level at 1000 μmol/l. She had myeloperoxidase-anti neutrophil cytoplasmic antibody, antithyroglobuline and antimicrosome antibodies. A renal biopsy revealed pauci-immune crescentic glomerulonephritis with 75% sclerous crescents. Chest-X-ray showed unilateral alveolar shadowing and a bronchio-alveolar lavage revealed lymphocytic alveolitis. She was treated with high dose of prednisolone and cyclophosphamide. After a follow-up of 18 months, the serum creatinine level decreased at 186 μmol/l and chest-X-ray returned to normal.Conclusion. – some cases of vasculatis associated with anti-thyroid drug treatment are reported [Copyright &y& Elsevier]

Renal lymphoma occurs most often as a part of a multi-systemic disseminated lymphoma or as a recurrence of the tumor. Renal involvement usually occurs late in the course of the disease and is clinically silent. Acute renal failure (ARF) from lymphomatous infiltration has been described but is quite rare. We report a 50-year-old Caucasian woman, who presented with features of ARF. Physical examination showed that her arterial blood pressure was 190/100 mm Hg with no lymphadenopathy or hepatosplenomegaly. Her urine output was about 100 ml/day, and urinanalysis revealed + proteinuria and microscopic hematuria. Biochemical findings revealed severely impaired renal function with a serum creatinine of 693 micromol/L. The patient's lactate dehydrogenase was elevated at 632 U/L. An abdominal ultrasound showed bilateral, large non-obstructed kidneys and a hypoechoic mass arising in the right lobe of the liver. An ultrasound-guided percutaneous liver biopsy showed typical features of B-cell lymphoblastic lymphoma. The patient expired two days later, even before any specific treatment could be started.

The association of myasthenia gravis (MG) and systemic lupus erythematosus (SLE) is a quite rare one. We report here one case and try to discuss the physiopathologic mechanisms and also the clinical, evolutive and therapeutic features of this morbid association. It's the case of a woman of 43 years old followed in our department since 1999. The patient has been treated by corticosteroids (prednisone) with monthly administered cyclophospamide pulses. Nine months lately, she develops a diplopia with a ptosis, a dysphagia and a muscular weakness. The treatment was mainly based on intravenous immunoglobulins. The later evolution was favourable. The coexistence of SLE and MG is not casual. It must be considered in every lupic patient developing neuromuscular troubles.

Introduction: Vasculitis is a rare complication of antithyroid drugs reported with propylthiouracil, carbimazole, methimazole and we describe the first case with benzylthyouracil. Renal involvement during thyroid auto-immune diseases and during vasculitis as complication of antithyroid drugs will be discussed., Exegesis: We present a case study of 28-year-old female patient with Graves' disease diagnosed in 1996 and treated by benzylthiouracil for 2 years. The thyroid function was poorly controlled, so surgical treatment was indicated in May 1998. One month later, she developed vasculitis with pulmonary and renal involvement. Her renal function deteriorated rapidly. On admission, the additional laboratory findings showed hematuria, proteinuria of 1.44 g/day and serum creatinine level at 1000 mumol/l. She had myeloperoxidase-anti neutrophil cytoplasmic antibody, antithyroglobulin and antimicrosome antibodies. A renal biopsy revealed pauci-immune crescentic glomerulonephritis with 75% sclerous crescents. Chest-X-ray showed unilateral alveolar shadowing and a bronchio-alveolar lavage revealed lymphocytic alveolitis. She was treated with high dose of prednisolone and cyclophosphamide. After a follow-up of 18 months, the serum creatinine level decreased at 186 mumol/l and chest-X-ray returned to normal., Conclusion: Some cases of vasculitis associated with anti-thyroid drug treatment are reported.

The authors report eight cases of MALT malignant lymphomas arising in the stomach in four cases, small intestine in two cases and salivary glands in two cases. The gastric lymphomas presented in the form of persistent epigastric pain sometimes lasting for several years, in patients with a mean age of 50.5 years. Gastroscopy revealed recurrent ulcerations in two cases and ulcerated or ulcero-fungating tumours in two cases. The two patients with alpha heavy chain disease, both 21 years of age, presented with chronic diarrhoea. The endoscopic appearance consisted of a pseudopolypoid tumour in one case and a mosaic appearance in the other case. The two salivary gland lymphomas involved the submandibular gland in two patients aged 30 years and 50 years. They presented in the form of nodules 1 and 2 cm in diameter, first detected by the patients two months and four months previously. Histological examination demonstrated the presence of typical lesions of MALT lymphoma with, in particular, the presence of constant lympho-epithelial lesions, various forms of centrocyte-like proliferation, varying degrees of plasma cell differentiation, reactive or residual lymphoid follicles in five cases, which were detected on biopsies in three cases. Immunohistochemistry confirmed the monoclonal nature of the tumour in seven cases, i.e. 87.5% of cases. The application of DBB42 and DNA7 antibodies onto paraffin sections demonstrated the absence of DNA7 labelling of CCL in line with Isaacson's findings in favour of the hypothesis of a non-centrofollicular origin of maltomas. Finally, we observed a single case of recurrence in a women with incomplete resection of the primary gastric tumour.

Diseases associated with renal amyloidosis were evaluated in 216 patients observed between 1956 and 1989. The percentage of secondary amyloidosis decreased from 72 to 47%, where it has remained for the past 20 years, despite the clear diminution in the tuberculosis rate; this is due to its increased incidence of association with rheumatoid diseases. Dysglobulinemia was found in more than 75% of the patients with AL amyloidosis. Amyloidosis associated with this dysglobulinemia, of which 30% were myelomatous, represented more than 25% of the cases observed during the past decade and constituted, with rheumatoid arthritis, the two most common etiologies.