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Vasculitis with renal and pulmonary involvement in a patient receiving benzylthiouracil for graves' s disease

Authors :
Kaaroud, H.
Khiari, K.
Ben Moussa, F.
Barbouch, S.
Boussema, E.
Ben Maïz, H.
Source :
Revue de Médecine Interne. Oct2002, Vol. 23 Issue 10, p857. 5p.
Publication Year :
2002

Abstract

Introduction. – Vasculitis is a rare complication of antithyroid drugs reported with propylthiouracil, carbimazol, methimazol and we discribe the first case with benzylthyouracil. Renal involvement during thyroid auto-immune diseases and during vasculitis as complication of antithyroid drugs will be discussed.Exegesis. – We present a case study of 28-year-old female patient with Graves'' disease diagnosed in 1996 and treated by benzylthiouracil for 2 years. The thyroid function was poorly controlled, so surgical treatment was indicated in May 1998. One month later, she developed vasculitis with pulmonary and renal involvement. Her renal function deteriorated rapidly. On admission, the additional laboratory findings showed hematuria, proteinuria of 1,44 g/day and serum creatinine level at 1000 μmol/l. She had myeloperoxidase-anti neutrophil cytoplasmic antibody, antithyroglobuline and antimicrosome antibodies. A renal biopsy revealed pauci-immune crescentic glomerulonephritis with 75% sclerous crescents. Chest-X-ray showed unilateral alveolar shadowing and a bronchio-alveolar lavage revealed lymphocytic alveolitis. She was treated with high dose of prednisolone and cyclophosphamide. After a follow-up of 18 months, the serum creatinine level decreased at 186 μmol/l and chest-X-ray returned to normal.Conclusion. – some cases of vasculatis associated with anti-thyroid drug treatment are reported [Copyright &y& Elsevier]

Details

Language :
French
ISSN :
02488663
Volume :
23
Issue :
10
Database :
Academic Search Index
Journal :
Revue de Médecine Interne
Publication Type :
Academic Journal
Accession number :
9630058