41 results on '"Boudjemaa B"'
Search Results
2. Chronic intestinal pseudo-obstruction in a child with Treacher Collins syndrome
- Author
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Giabicani, P, Lemale, P, Dainese, P, Boudjemaa, B., Coulomb, P, Tounian, P., Dubern, B., Giabicani, Eloïse, Lemale, J., Dainese, L., Boudjemaa, S., Coulomb, A., Department of Ecology and Environment, Université de Tlemcen, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut National de la Santé et de la Recherche Médicale (INSERM), Sorbonne Université (SU), CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Méthodes d'Analyses pour le Traitement d'Images et la Stéréorestitution (MATIS), Laboratoire des Sciences et Technologies de l'Information Géographique (LaSTIG), École nationale des sciences géographiques (ENSG), Institut National de l'Information Géographique et Forestière [IGN] (IGN)-Institut National de l'Information Géographique et Forestière [IGN] (IGN)-École nationale des sciences géographiques (ENSG), and Institut National de l'Information Géographique et Forestière [IGN] (IGN)-Institut National de l'Information Géographique et Forestière [IGN] (IGN)
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0301 basic medicine ,Intestinal pseudo-obstruction ,Male ,Pathology ,medicine.medical_specialty ,Abdominal pain ,Facial bone ,030105 genetics & heredity ,03 medical and health sciences ,MESH: Child ,Medicine ,Humans ,Child ,MESH: Intestinal Pseudo-Obstruction ,[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics ,MESH: Humans ,business.industry ,MESH: Chronic Disease ,Intestinal Pseudo-Obstruction ,[SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism ,medicine.disease ,Hypoplasia ,MESH: Male ,3. Good health ,Palpebral fissure ,Atresia ,Pediatrics, Perinatology and Child Health ,Chronic Disease ,MESH: Mandibulofacial Dysostosis ,medicine.symptom ,business ,Haploinsufficiency ,Treacher Collins syndrome ,Mandibulofacial Dysostosis - Abstract
Summary Background Treacher Collins syndrome (TCS) mainly presents with severe craniofacial developmental abnormalities characterized by a combination of bilateral downward-slanting palpebral fissures, colobomas of the lower eyelids, hypoplasia of the facial bones, cleft palate, malformation of the external ears, atresia of the external auditory canals, and bilateral conductive hearing loss. It is due to mutations in Treacher Collins syndrome 1 (TCOF1) (5q32–q33.1) and Polymerase RNA 1 polypeptides D and C (POLR1D [13q12.2], and POLR1 C [6p21.1]) genes, which are responsible for increased neuroepithelial apoptosis during embryogenesis resulting in the lack of neural crest cells involved in facial bone and cartilage formation. Altered function of the upper digestive tract has been reported, whereas severe dysmotility disorders have never been reported. We describe here the first case of TCS associated with histologically proven chronic intestinal pseudo-obstruction (CIPO) in humans. Case presentatios A 12-year-old boy with TCS due to TCOF1 gene deletion experienced nutritional difficulties and digestive intolerance from birth. CIPO was suspected during childhood because of severe intestinal dysmotility leading to enteral-jejunal nutrition intolerance and dependence on total parenteral nutrition. Diagnosis of CIPO with nervous abnormalities was histologically confirmed on a surgical rectal biopsy that showed enlarged ganglionic myenteric plexus. At the age of 9 years, an isolated colonic stenosis without dilatation responsible for severe abdominal pain and altered quality of life led to digestive derivation contributing to rapid disappearance of chronic abdominal pain. At the age of 12 years, the patient was still dependent on total home parenteral nutrition 7 days a week to maintain regular growth velocity. Conclusion Recently, mice studies have pointed out the role played by TCOF1 in ganglionic cell migration in the foregut, suggesting that the synergistic haploinsufficiency of Tcof1 and Pax3, a transcription factor regulating the RET gene involved in disorders of neural crest cell development, probably results in colonic aganglionosis and may explain the association described here between TCS and CIPO. This case may correspond to this possible mechanism in humans. These findings and our clinical report suggest that CIPO may be assessed as unusual digestive manifestations in TCS with TCOF1 deletion.
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- 2017
3. Sensory, microbiological and physico-chemical characterization of Klila, a traditional cheese made in the south-west of Algeria
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Benamara, R. N., primary, Gemelas, L., additional, Ibri, K., additional, Moussa-Boudjemaa, B., additional, and Demarigny, Y., additional
- Published
- 2016
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4. Perspectives in mathematical modelling for microbial ecology
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Wade, M.J., primary, Harmand, J., additional, Benyahia, B., additional, Bouchez, T., additional, Chaillou, S., additional, Cloez, B., additional, Godon, J.-J., additional, Moussa Boudjemaa, B., additional, Rapaport, A., additional, Sari, T., additional, Arditi, R., additional, and Lobry, C., additional
- Published
- 2016
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5. Bioprospecting of Leuconostoc mesenteroides strains isolated from Algerian raw camel and goat milk for technological properties useful as adjunct starters
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ZAROUR, K., BENMECHERNENE, Z., HADADJI, M., MOUSSA-BOUDJEMAA, B., HENNI, D., and KIHAL, M.
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milk ,fluids and secretions ,Technological ,growth kinetic ,food and beverages ,carbon dioxide ,yeast extract ,Leuconostoc ,antibiotics - Abstract
Leuconostoc species are lactic acid bacteria widely used in milk fermentation. Based on morphological, physiological and biochemical analysis, 18 strains of Leuconostoc mesenteroides were isolated and identified from 10 samples of goat's milk and camel's milk. Strains were identified as follows 09 strains of L. mesenteroides subsp. mesenteroides and 09 strains of L. mesenteroides subsp. dextranicum The results of technological tests of the strains showed that strains produced dextran, carbon dioxide, and resist to 55°C for 15 min, which promote their industrial use. The growth kinetic, acidif cation evolution and carbon dioxide production of L. mesenteroides subsp. dextranicum strain in skim milk at 30°C were slightly higher than L. mesenteroides subsp. mesenteroides. Addition of yeast extract to skim milk stimulates the development of L. mesenteroides subsp. mesenteroides by increasing its growth, acidification activity and evolved CO2. Susceptibility to antibiotics was also evaluated on 33 antibiotics and strains of L. mesenteroides showed resistance to 42.4% of antibiotics used.
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- 2012
6. Identification and genetic diversity of Bacillus cereus strains isolated from a pasteurized milk processing line in Algeria
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Malek, F., primary, Boudjemaa, B. Moussa, additional, Aouar-Métri, A., additional, and Kihal, M., additional
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- 2012
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7. [Simultaneous thrombosis of the left anterior interventricular and right coronary arteries in a 27 year-old patient with protein S deficiency]
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didier CARRIE, Béard T, Sié P, Boudjemaa B, Delay M, and Bernadet P
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Adult ,Male ,Protein S Deficiency ,Coronary Thrombosis ,Myocardial Infarction ,Humans ,Blood Coagulation Tests ,Angioplasty, Balloon, Coronary ,Coronary Angiography - Abstract
The authors report a case of myocardial infarction in a 27 year old patient by simultaneous thrombosis of the left anterior descending and right coronary arteries in an angiographically normal coronary circulation. The young age of the patient, the absence of the usual risk factors and a normal angiographic network after arterial recanalisation by angioplasty led to the search for a risk factor of thrombosis. This showed a qualitative deficiency of protein S and the absence of any other abnormality of coagulation or fibrinolysis. This case raises the question of a causal relationship between a hereditary protein S deficiency and thrombotic arterial occlusion.
- Published
- 1993
8. [Cardiocirculatory arrest after administration of combined mifepristone (Mifegyne) and sulprostone (Nalador) for induced abortion. Possible role of coronary vasospasm]
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Delay M, Genestal M, didier CARRIE, Livarek B, Boudjemaa B, and Bernadet P
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Abortifacient Agents, Nonsteroidal ,Electric Countershock ,Coronary Vasospasm ,Heart ,Dinoprostone ,Heart Arrest ,Drug Combinations ,Electrocardiography ,Mifepristone ,Thallium Radioisotopes ,Pregnancy ,Risk Factors ,Ventricular Fibrillation ,Humans ,Female ,Abortion, Therapeutic ,Radionuclide Imaging - Abstract
Reversible ventricular fibrillation occurred in a 35 year old multiparous woman after the administration of the association mifepristone (Mifegyne) and sulprostone (Nalador) for therapeutic abortion. A coronary spasm induced by the analogue of the prostaglandin PGE 2x was though to be the causative mechanism and was reproduced by the Ergonovine test. The evolution of the ECG and myocardial scintigraphy suggested a slowly regressive stunned myocardium.
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- 1992
9. Nanocolumnar TiN thin film growth by oblique angle sputter-deposition: Experiments vs. simulations
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Boudjemaa Bouaouina, Cédric Mastail, Aurélien Besnard, Rubenson Mareus, Florin Nita, Anny Michel, and Grégory Abadias
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Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
Nanostructured columnar titanium nitride (TiN) thin films were produced by oblique angle deposition using reactive magnetron sputtering. The influence of the angular distribution of the incoming particle flux on the resulting film morphology (column tilt angle, porosity, surface roughness) was studied by varying the inclination angle α of the substrate at two different working pressures, 0.3 and 0.5 Pa. The microstructural features and columns tilt angles βexp determined experimentally were compared to those simulated from two kinetic Monte Carlo (KMC) models. With increasing pressure, the TiN columns were found to be less defined but no significant changes in βexp were revealed. Both KMC models satisfactorily reproduced the experimental findings, the agreement being closer at 0.5 Pa. The evolution of β angle is also discussed with respect to the resulting incidence angle θres of the incoming flux, this latter quantity accounting for the local incidence angle of individual particles, which may greatly differ from the geometrical angle α, especially at high working pressure due to the incoming particle – gas collisions. Crossover phenomena between the 0.3 and 0.5 Pa series were revealed from the evolution of the film resistivity, as well as simulated layer density and surface roughness versus α angle. Keywords: TiN, Reactive magnetron sputtering, Monte Carlo simulations, Particle flux, GLAD
- Published
- 2018
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10. Heat resistance of Bacillus cereus spores in carrot extract acidified with different acidulants
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Moussa-Boudjemaa, B., Gonzalez, J., and Lopez, M.
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BACILLUS cereus , *CARROTS , *HEAT , *ACIDIFICATION - Abstract
Abstract: The effect of acidification of carrot extract on the heat resistance of Bacillus cereus (ATCC 7004 and 4342) spores was studied. Malic, acetic, citric, ascorbic, lactic and hydrochloric acids were used as acidulants. Thermal resistance experiments were performed over the range 82–108°C with continuous monitoring of pH. Non-acidified carrot extract (pH 5.2) had a protective effect on the thermal inactivation of spores when compared with the reference McIlvaine buffer at the same pH value. Acidification of carrot extract reduced the D-values obtained for spores, this effect occurring whatever the type of acidulant used. For both strains and all treatment temperatures, as pH decreased the D-values decreased exponentially over the pH range studied (5.2–4.0), yielding straight lines, basically parallel, with an average slope of 0.203±0.023. Significant decreases in survivor counts and apparent D-values were observed when injured spores were recovered using the usual recovery medium containing carrot extract. [Copyright &y& Elsevier]
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- 2006
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11. On Sustaining Dynamic Adaptation of Context-Aware Services
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Boudjemaa Boudaa, Slimane Hammoudi, Abdelkader Bouguessa, Leila Amel Mebarki, and Mohammed Amine Chikh
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Context-Aware Service ,Dynamic Adaptation ,Model-Driven Development ,MAPE-K ,Technology (General) ,T1-995 - Abstract
The modern human is getting more and more mobile having access to online services by using mobile cutting-edge computational devices. In the last decade, the field of context-aware services had led to emerge several works. However, most of the proposed approaches have not provided clear adaptation strategies in case of unforeseen contexts. Dealing with this last at runtime is also another crucial need that has been ignored in their proposals. This paper aims to propose a generic dynamic adaptation process as a phase in a model-driven development life-cycle for context-aware services using the MAPE-K control loop to meet the runtime adaptation. This process is validated by implementing an illustrative application on FraSCAti platform. The main benefit of the proposed process is to sustain the self-reconfiguration of such services at model and code levels by enabling successive dynamic adaptations depending on the changing context.
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- 2015
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12. Gypsum-Catalyzed One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H) Under Solvent-Free Conditions
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Taoues Boumoud, Boudjemaa Boumoud, Paul Mosset, and Abdelmadjid Debache
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Chemistry ,QD1-999 - Abstract
In view of the emerging importance of the green chemistry principles in chemical and pharmaceutical industries, we disclose, herein, a new economic approach producing the biologically active dihydropyrimidinones in good yields using the solventless one-pot Biginelli condensation in the presence of gypsum as an environmental friendly and recycled catalyst.
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- 2011
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13. A Convenient Access to Biquinoline Carbaldehydes using Nickel-Phosphine Complex-Mediated Homocoupling of Haloquinoline Carbaldehydes in One-Pot Reaction
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Ahmed Benameur, Taoues Boumoud, Boudjemaa Boumoud, and Salah Rhouati
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Chemistry ,QD1-999 - Abstract
The homocoupling of 2-chloro-carbaldehyde derivatives gave the corresponding 2,2’-biquinolines by using the in situ generated reactive reagent Ni[(PPh3)]4. Several new 2-chloro-3-(1.3 dioxalan-2yl) quinoline derivatives are synthesized and structurally characterized. The overall structures of biquinoline derivatives are not planar.
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- 2010
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14. [The value of Doppler echocardiography in the diagnosis of pulmonary artery hypertension in chronic obstructive bronchopneumopathies]
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Didier A, Boudjemaa B, Coca F, Rivière D, Rm, Rouquet, and Leophonte P
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Adult ,Heart Failure ,Male ,Cardiac Catheterization ,Systole ,Hypertension, Pulmonary ,Blood Pressure ,Middle Aged ,Pulmonary Artery ,Echocardiography ,Humans ,Female ,Lung Diseases, Obstructive ,Aged - Abstract
We report a study using Doppler echocardiography looking for pulmonary arterial hypertension (HTAP) in 36 patients presenting with chronic airflow obstruction (BPCO) who are in a stable state. 18 of these (group 1) had confirmed HTAP by right heart catheterisation which had been done the day before and was defined as a mean pulmonary arterial pressure (PAPm) of greater than 20 mm of mercury. The other 18 patients (group 2) did not have HTAP at rest. The systolic ejection flow and the duration of the peak (expressed in msec) was analysed at the time of each examination. The Doppler data was compared between the two groups of patients and also with the results obtained in ten healthy subjects. The Doppler examination was successfully performed in 35 patients in spite of a poor echographic window in 86% of cases. When there was HTAP, the systolic ejection flow had a triangular aspect which contrasted with the dome shaped appearance of the normals. In group 1 the peak time was significantly shortened (p less than 0.01) compared to group 2 and to the healthy subjects. On the other hand there was no linear correlation between the value of the peak time and the level of HTAP measured by the catheter. Thus the severity of HTAP could not be precisely measured using these parameters. In considering that the peak time is normally greater than 100 msec, the sensitivity and specificity of the Doppler examination for the detection of HTAP during the course of BPCO are 90 and 88% respectively, which appears to be superior to the values obtained using other non invasive methods in the diagnosis of HTAP.
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- 1988
15. An Efficient and Recycling Catalyst for the One-Pot Three-Component Synthesis of Substituted 3,4-Dihydropyrimidin-2(1H)-ones
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Taoues Boumoud, Boudjemaa Boumoud, Salah Rhouati, Ali Belfaitah, Abdelmadjid Debache, and Paul Mosset
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Chemistry ,QD1-999 - Abstract
The Biginelli one-pot three-component cyclocondensation was applied in this work to prepare 3,4-dihydropyrimidinone and its analogues using the first derivative of lead, Pb(NO3)2, as a recycling catalyst, from a diversity of aromatic aldehydes, β-ketoesters and urea. The reaction was carried out in refluxing acetonitrile and afforded the target molecules in good to excellent yields. The method offers several advantages including high yields of the products, short reaction times and easy experimental workup procedure
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- 2008
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16. [Systematic cardiovascular evaluation and hypercholesterolemia. Results in 200 asymptomatic patients]
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Ferrières J, Denat M, Delay M, didier CARRIE, Boudjemaa B, Douste-Blazy P, and Bernadet P
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Adult ,Carotid Artery Diseases ,Male ,Aging ,Arteriosclerosis ,Hypercholesterolemia ,Constriction, Pathologic ,Coronary Artery Disease ,Middle Aged ,Coronary Angiography ,Exercise Test ,Humans ,Mass Screening ,Female ,Radionuclide Imaging ,Aged ,Ultrasonography - Abstract
This study reports the results of routine evaluation to detect coronary and carotid atherosclerosis in 200 asymptomatic and hypercholesterolemic patients (48 +/- 10 years: 72.5% men). All patients underwent physical examination, blood lipid profile, an exercise test and cervical echo-doppler. If the exercise electrocardiogram was abnormal, a thallium isotope scan and/or coronary arteriography were performed. Hypercholesterolemia was severe (3.03 +/- 0.52 g/l). 77.5% of patients had pure hypercholesterolemia. Carotid atherosclerosis in the form of plaque (27.5%) or stenosis (3.5%) was found in 31% of patients. This carotid atheroma was commoner in older patients (51.9 +/- 9 years as against 47 +/- 10 years, p0.01). Twenty patients (10%) had electrical signs of ischemia provoked by exercise. Six of them had a normal thallium isotope scan and did not undergo coronary arteriography. Coronary arteriography was abnormal in 10 patients (5%): 7 had stenotic lesions and 3 showed evidence of spasm during the methylergometrine test. In total, the hypercholesterolemic patients investigated here were characterised by subclinical atherosclerosis which was frequent but certainly underestimated by non-invasive studies. The existence of an atherosclerotic lesion is an additional argument in favour of starting cholesterol-lowering treatment.
17. [Value of continuous measurement of mixed venous oxygen saturation (SVO2) during coronary angioplasty]
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didier CARRIE, Boudjemaa B, Derbel F, Ferrières J, Delay M, and Bernadet P
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Adult ,Male ,Hemodynamics ,Coronary Disease ,Stroke Volume ,Middle Aged ,Ventricular Function, Left ,Veins ,Oxygen ,Humans ,Female ,Oximetry ,Angioplasty, Balloon, Coronary ,Aged ,Monitoring, Physiologic - Abstract
Mixed venous oxygen saturation (SVO2) is an haemodynamic parameter of cardiovascular function. The object of this study was to measure SVO2 during percutaneous transluminal coronary angioplasty (PTCA) with prolonged balloon inflation in order to evaluate haemodynamic tolerance more precisely in two groups of patients. Twenty-six patients undergoing PTCA were divided into two groups: Group I, N = 15, with single vessel disease and good left ventricular function (EF: 61.63 +/- 10.1%); Group II, N = 11, with triple vessel disease and poor left ventricular function (EF: 48.05 +/- 14%; p0.05). Continuous monitoring of SVO2 with an oximetrix fiber optic catheter was performed in all patients during PTCA. Irrespective of the duration of balloon inflation, a significant correlation was observed between the changes in cardiac output and VSO2. Given that arterial oxygen pressure, global oxygen consumption and haemoglobin concentrations remained constant during balloon inflation, SVO2 was an indicator of cardiac output.
18. [Unstable angina in patients over 70 years of age]
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didier CARRIE, Boudjemaa B, Fajadet J, and Bernadet P
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Aged, 80 and over ,Male ,Risk Factors ,Hemodynamics ,Humans ,Female ,Angina, Unstable ,Coronary Angiography ,Angioplasty, Balloon ,Aged ,Angina Pectoris ,Follow-Up Studies - Abstract
Between October, 1985 and June, 1987, 125 patients aged 70 years or more were admitted to the Cardiology Department of Purpan Hospital, Toulouse for unstable angina pectoris. 107 of these patients have been followed up, i.e.: 76 men and 31 women aged from 70 to 85 years (mean 74.5 +/- 3.2 years). 49 patients (46 p. 100) had angina at rest of the intermediate syndrome type; 46 (43 p. 100) had rapidly progressive effort angina, and 12 (11 p. 100) had effort angina de novo. The patients' general condition was preserved in 85 p. 100 of the cases and altered in 15 p. 100. ECG was normal in only 10 p. 100 of the patients; it showed signs of established ischaemia in 70 p. 100 of the cases and sequelae of infarction in 23 p. 100. The mean cardiothoracic ration was 49.9 +/- 4.8 p. 100. The ejection fraction was 62 +/- 14.6 p. 100, the end-diastolic volume 86.9 +/- 32.2 ml/m2 and the left ventricular end-diastolic pressure 15.8 +/- 7.2 mmHg. 69 patients (64.5 p. 100) had calcifications in their coronary arteries. At coronary arteriography 21 patients (19.6 p. 100) showed stenosis of the main stem, 11 patients (10.3 p. 100) had a single vessel disease, 28 (26.2 p. 100) a two-vessel disease and 47 (43.9 p. 100) a three-vessel disease. Treatment was medical in 41 patients (38.3 p. 100) and surgical in 44 patients (41.12 p. 100); transluminal coronary angioplasty (TCA) was performed in 23 patients (21.5 p. 100).(ABSTRACT TRUNCATED AT 250 WORDS)
19. [Acute severe coxsackie virus B myocarditis of pseudonecrotic form. Apropos of 2 cases]
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Beard T, Boudjemaa B, didier CARRIE, Chakra G, Ferrières J, Delay M, and Bernadet P
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Adult ,Male ,Myocarditis ,Necrosis ,Acute Disease ,Coxsackievirus Infections ,Humans ,Female ,Enterovirus B, Human - Abstract
This study reports two cases of acute severe Coxsackie virus B4 myocarditis in which the immediate clinical signs suggested the acute phase of myocardial infarction, apparently antero-lateral in the first case in a context of cardiogenic shock and infero-lateral in the second case, in the context of acute pulmonary edema. Both cases were characterized by the severity of the initial signs. Numerous other cases of acute Coxsackie virus B myocarditis, simulating myocardial infarction, have been reported in the literature and these contexts deserve to be recognized earlier as they call for specific treatment. The immediate outcome was favorable in both cases but required massive cardiological intensive care in the first patient. Long term follow-up was excellent.
20. [Infarction in patients aged over 70. Apropos of 194 patients]
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Beard T, didier CARRIE, Boudjemaa B, Ferrières J, Delay M, and Bernadet P
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Aged, 80 and over ,Male ,Aging ,Angioplasty ,Myocardial Infarction ,Hospitalization ,Treatment Outcome ,Risk Factors ,Surveys and Questionnaires ,Humans ,Female ,Thrombolytic Therapy ,Aged ,Follow-Up Studies - Abstract
Among 498 patients hospitalised for myocardial infarction during a three year period, 194 (39%) were aged over 70 (mean age: 78.6 +/- 6), including 99 women and 95 men. Comparison of this group of patients with those aged under 70 showed a significantly higher hospital mortality (17.5% v. 6.5%) (p0.01) and a higher acute complication rate (60.8% v. 23.7% (p0.01), in particular after the age of 75. Twenty-eight patients were treated by thrombolysis (14.4% v. 50.6%) (p0.05), with a 79.2% patency rate in follow-up angiography at 48 h, and only one non-fatal hemorrhagic complication. Eighty-six patients were investigated by coronary arteriography (44.9% v. 87.2% (p0.05) without any complication. Mean ejection fraction was 57.3 +/- 13.5%. Fifty patients were treated by angioplasty (24.6% v. 57%) (p0.01) including 15 during the acute phase, with primary success in 40 of them (80%). Ten patients underwent coronary bypass following their infarction (5.1% v. 6.25%) (NS) with two per- or postoperative deaths (20%). Follow-up study revealed high secondary mortality with an overall survival rate at one year of 59.6% v. 81% in patients aged under 70 (p0.01). In total, infarction in the elderly is characterised by high mortality and morbidity as compared with infarctions in patients aged under 70, and requires active management during the acute phase, assessed according to the physiological status and age of the patient.
21. [Study of left ventricular diastolic function using pulsed Doppler in myocardial infarct in hypertensive subjects]
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Boudjemaa B, didier CARRIE, Granier P, My, Douste-Blazy, Beard T, Galinier F, and Bernadet P
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Diastole ,Heart Ventricles ,Hypertension ,Myocardial Infarction ,Humans ,Middle Aged ,Echocardiography, Doppler ,Aged - Abstract
To determine if impairment of left ventricular filling is influenced by acute myocardial infarction in patients with arterial hypertension, left ventricular diastolic function was assessed by pulsed doppler echocardiography in 46 patients (pts) subdivided into four groups (Gr): G.1 (n = 12 pts) with acute myocardial infarction and hypertensive heart disease. G.2 (n = 12 pts) acute myocardial infarction without arterial hypertension. G.3 (n = 10 pts) arterial hypertension without history of coronary artery disease. G.4 (n = 12 pts) healthy subjects. Coronary angiography and left ventricular cineangiogram was performed in 24 pts (G.1 + G.2). Peak mitral flow velocity (cm/s) in early diastole (E), atrial systole (A), A/E and int A/int E ratios were measured by pulsed doppler. Age and heart rate were statistically similar in all groups. No difference was found among G.1 and G.2 in ejection fraction, and left ventricular segmental kinetic. (tables; see text) Conclusion left ventricular filling is impaired in pts with arterial hypertension and in pts with acute myocardial infarction; acute myocardial infarction increase the impairment of left ventricular diastolic function in pts with hypertensive heart disease.
22. [Production of oxygen free radicals in myocardial infarction treated by thrombolysis. Analysis of glutathione peroxidase, superoxide dismutase and malondialdehyde]
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Béard T, didier CARRIE, Mj, Boyer, Boudjemaa B, Ferrières J, Delay M, Bernadet P, and Jp, Thouvenot
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Adult ,Male ,Glutathione Peroxidase ,Erythrocytes ,Free Radicals ,Superoxide Dismutase ,Myocardial Infarction ,Middle Aged ,Oxygen ,Selenium ,Fibrinolytic Agents ,Malondialdehyde ,Humans ,Female ,Thrombolytic Therapy ,Aged - Abstract
Many enzyme systems such as glutathione peroxidase (GPx) or superoxide dismutase (SOD) neutralise the oxygen derived free radicals produced during myocardial reperfusion by thrombolysis. Erythrocytic SOD, plasma and erythrocytic GPx and their cofactor selenium, substances reacting with thiobarbituric acid (TBARS) were analysed by repeated sampling between T0 and 48 hours in 24 patients treated by thrombolysis for acute myocardial infarction. Angiographic control was undertaken systematically between 60 and 180 minutes after initiating thrombolytic therapy: 18 patients had a patent vessel and 6 patients had an occluded vessel recanalised in 5 cases by angioplasty. Biological analysis was performed in the 23 patients successfully revascularised by thrombolysis, eventually completed by angioplasty. The plasma GPx decreased non-significantly between T0 and 2 hours from 246.8 +/- 53.3 to 233 +/- 39 U/ml with a significant increase between 2 and 48 hours from 233 +/- 39.2 to 294 +/- 76 U/ml, whereas the erythrocytic GPx rose significantly and constantly between T0 and 48 hours from 34.8 +/- 7.1 to 37.6 +/- 7.5 U/gHb with significant consumption of selenium between T0 and 4 hours from 81.2 +/- 14 to 68.5 +/- 12.6 micrograms/l. The erythrocytic SOD increased significantly between T0 and 48 hours from 318.9 +/- 40.8 to 337 +/- 59 U/gHb. Finally, the analysis of plasma TBARS showed a non-significant rise between T0 and 30 minutes from 1.59 +/- 0.30 to 1.71 +/- 1.43 mm/l with a return to the basic line values after about 2 hours. These results show a significant increase in the activity of enzymes protecting against the liberation of oxygen free radicals, such as erythrocyte or plasma GPx and erythrocyte SOD between T0 and 48 hours with consumption of selenium, cofactor of GPx, and an increase in circulating lipid peroxydes in acute myocardial infarction treated by thrombolysis. They also illustrate the oxidative stress which occurs in this situation.
23. Preparation, DFT calculations, docking studies, antioxidant, and anticancer properties of new pyrazole and pyridine derivatives.
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Zebbiche Z, Şekerci G, Boulebd H, Küçükbay F, Tekin S, Tekin Z, Küçükbay H, Sandal S, and Boumoud B
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- Caco-2 Cells, DNA Topoisomerases, Type II, Density Functional Theory, Docetaxel, Humans, Hydrazines, Molecular Docking Simulation, Molecular Structure, Pyrazoles chemistry, Pyrazoles pharmacology, Pyridines chemistry, Pyridines pharmacology, Structure-Activity Relationship, Antineoplastic Agents chemistry, Antineoplastic Agents pharmacology, Antioxidants chemistry, Antioxidants pharmacology
- Abstract
Seven novel pyrazole derivatives (4a-g) and four novel starting compounds incorporating substituted pyridine moieties were synthesized successfully. Cell viability assay for the tested compounds was performed, and the inhibitory concentrationlogarithmic 50 (LogIC
50 ) values of the compounds were calculated after a 24-h treatment. Four of the examined compounds (3d, 3g, 4f, and 4g) showed comparable cytotoxic activity against CaCo-2 compared to the standard drug docetaxel at 0.1 and 1 μM concentrations. Although the LogIC50 of docetaxel was -0.678 μM for CaCo-2 cells at 24 h, the LogIC50 values of compounds were -0.794, -0.567, -0.657, and -0.498 μM, respectively. Five of the compounds (2d, 2g, 3d, 3g, and 4e) showed comparable cytotoxic activity against MCF-7 at 0.1 μM concentration compared to docetaxel (p < 0.05). Docking studies revealed the compounds have a good affinity to the active site of the human topoisomerase II β enzyme. The antioxidant capacities of all compounds were determined using both 1,1-diphenyl-2-picrylhydrazyl and metal chelation methods. Although the compounds did not show significant antioxidant activity, relatively effective are compounds 3c, 3d, and 3g, which are hydrazine derivatives with approximately 50% antioxidant activity of standard antioxidants at concentrations of 62.5 and 125 μg/ml., (© 2022 Wiley Periodicals LLC.)- Published
- 2022
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24. Aerobic spore-forming bacteria in powdered infant formula: Enumeration, identification by MALDI-TOF mass spectrometry (MS), presence of toxin genes and rpoB gene typing.
- Author
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Mezian L, Chincha AIA, Vecchione A, Ghelardi E, Bonatto JMC, Marsaioli AJ, Campelo PH, Benamar I, Moussaoui AA, Sant'Ana AS, and Moussa-Boudjemaa B
- Subjects
- Bacillus cereus genetics, Food Microbiology, Humans, Phylogeny, Powders, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Spores, Bacterial genetics, Bacteria, Aerobic, Infant Formula
- Abstract
This study aimed to assess the counts and biodiversity characterization of aerobic sporeforming bacteria (ASB) in powdered infant formula (PIF). Fifty-four (n = 54) samples of PIF of three brands were analyzed for mesophilic aerobic bacteria, and ASB counts. ASB isolated from PIF were assessed for their ability to produce spoilage enzymes and hemolytic activity and further identified by MALDI-TOF mass spectrometry. Then, the isolates were subjected to rpoB gene typing and assessment of bceT, entFM, nhe (A, B, C), and hbl (A, B, C) toxin genes. The main species isolated were B. licheniformis (54%), followed by B. cereus (33%) and B. subtilis (5%). The ASB counts ranged from 1 to 4 log CFU/g, and the mean was 2.9 log CFU/g for mesophilic aerobic sporeforming bacteria (MSC) and 2.5 log CFU/g for thermophilic aerobic sporeforming bacteria (TSC). Most PIF samples presented MSC and TSC counts between 2 and 3 log CFU/g. A total of 13%, 50%, and 37% of the samples presented MSC counts from <2 log CFU/g, between 2 and 3 log CFU/g and between 3 and 4 log CFU/g, respectively. Among the ASB isolates, 97% had protease, 84% hydrolyzed starch, 66% had hemolytic activity, and 61% had lecithinase activity. A total of 44 out of 120 isolates harbored at least one toxin gene; 56% for B. cereus, 34% for B licheniformis, and less than 5% for B. subtilis, B pumilus, and L. sphaericus. All B. cereus isolates harbored the nhe gene, 60% entFM, 44% cytK, 32% bceT, and 28% hbl genes. Besides, 17% of B. licheniformis harbored nhe. A small proportion of B. subtilis, B. pumilus, and L. sphaericus carried toxin genes. The rpoB based phylogenetic tree provided high resolution among Bacillus species. The findings of this study provide insights into the phenotypic and genotypic biodiversity of Bacillus present in PIF., (Copyright © 2022 Elsevier B.V. All rights reserved.)
- Published
- 2022
- Full Text
- View/download PDF
25. Synthesis and anticancer properties of novel hydrazone derivatives incorporating pyridine and isatin moieties.
- Author
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Zebbiche Z, Tekin S, Küçükbay H, Yüksel F, and Boumoud B
- Subjects
- Antineoplastic Agents chemical synthesis, Antineoplastic Agents chemistry, Cell Line, Tumor, Cell Proliferation drug effects, Cell Survival drug effects, Dose-Response Relationship, Drug, Drug Screening Assays, Antitumor, Humans, Hydrazones chemical synthesis, Hydrazones chemistry, Isatin chemistry, Molecular Structure, Pyridines chemistry, Structure-Activity Relationship, Antineoplastic Agents pharmacology, Hydrazones pharmacology, Isatin pharmacology, Pyridines pharmacology
- Abstract
Nine novel hydrazone derivatives (4a-i) incorporating pyridine and isatin moieties were synthesized through one-pot, four-component heterocyclic condensation reactions. The structures of all new compounds (2a-e, 3a, 3c-e, and 4a-e) were identified by
1 H nuclear magnetic resonance (NMR),13 C NMR, and Fourier-transform infrared spectroscopic techniques and elemental analysis. Cell viability assays for the tested hydrazone derivatives were performed and the log IC50 values of the compounds were calculated after a 24-h treatment. All hydrazide derivatives tested showed a promising antitumor activity against A-2780 cells as compared with the standard drug docetaxel with a log IC50 value of 0.2200 μM (p < .05). Seven of the examined compounds (4b-e, 4g-i) showed high cytotoxic activity against A-2780 cells as compared with the standard drug docetaxel. Whereas the log IC50 of docetaxel was 0.2200 μM for A-2780 cells at 24 h, the IC50 values of these compounds were -0.4987, -0.4044, -0.8138, -0.3868, -0.6954, -0.4751, and 0.1809 μM, respectively. Three of the compounds, 4b, 4d, and 4i, showed high cytotoxic activity against MCF-7 cells as compared with docetaxel (p < .05). Whereas the log IC50 of docetaxel was 0.2400 μM for MCF-7 cells at 24 h, the log IC50 values of compounds 4b, 4d, and 4i were -0.1293, -0.1700, and 0.2459 μM, respectively., (© 2020 Deutsche Pharmazeutische Gesellschaft.)- Published
- 2021
- Full Text
- View/download PDF
26. Antimicrobial and Antioxidant Effects of a Forest Actinobacterium V 002 as New Producer of Spectinabilin, Undecylprodigiosin and Metacycloprodigiosin.
- Author
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Gacem MA, Ould-El-Hadj-Khelil A, Boudjemaa B, and Wink J
- Subjects
- Algeria, DNA, Bacterial, Fatty Acids, Forests, Phylogeny, Prodigiosin analogs & derivatives, Pyrones, RNA, Ribosomal, 16S genetics, Sequence Analysis, DNA, Soil Microbiology, Streptomyces, Anti-Infective Agents, Antioxidants
- Abstract
The aim of the study is the research and identification of a Streptomyces strain as a new producer of spectinabilin, undecylprodigiosin and metacycloprodigiosin. Among 54 actinomycete isolates isolated from El-Ogbane forest soils in Algeria, only one isolate, designated V
002 , was selected for its ability to produce prodigiosins. The selected strain was analysed for its ability to produce three different secondary metabolites as well as their biological activities. V002 belongs to the Streptomyces genus and has significant antimicrobial and antioxidant activities. The taxonomic position of V002 by 16S rRNA sequence analysis showed a similarity of 99.93% with Streptomyces lasiicapitis DSM 103124T and 98.96% with Streptomyces spectabilis DSM 40512T . Fractionation of crude secondary metabolites produced by the strain using HPLC-MS revealed the presence of spectinabilin, undecylprodigiosin and metacycloprodigiosin, which demonstrated significant activity. Strain V002 is considered a new producer of spectinabilin, undecylprodigiosin and metacycloprodigiosin with significant antimicrobial and antioxidant activity.- Published
- 2020
- Full Text
- View/download PDF
27. Dataset on the hygrothermal performance of a date palm concrete wall.
- Author
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Alioua T, Agoudjil B, Chennouf N, Boudenne A, and Benzarti K
- Abstract
The present data article is concerned with the hygrothermal performance at the wall scale of a new bio-based building material including date palm fibres. A specific test setup allowed to measure temperature and relative humidity (RH) profiles at three different depths of the bio-based wall subjected to outdoor boundary conditions. Besides, a partial differential equations resolution software was then used to solve two mathematical models ( i.e. , Kunzel and Mendes models) describing heat and moisture transfer in porous building materials. Both experimental/simulated temperature and RH profiles are provided with this dataset article. The proposed experimental setup can be used for studying the hygrothermal performance of different kinds of bio-based building materials at wall scale, while experimental/numerical data can serve as reference values for the validation of mathematical models intended to describe heat and mass transfer., (© 2019 The Author(s).)
- Published
- 2019
- Full Text
- View/download PDF
28. Purification and biochemical characterization of a highly thermostable xylanase from Actinomadura sp. strain Cpt20 isolated from poultry compost.
- Author
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Taibi Z, Saoudi B, Boudelaa M, Trigui H, Belghith H, Gargouri A, and Ladjama A
- Subjects
- Actinomycetales chemistry, Amino Acid Sequence, Animals, Bacterial Proteins genetics, Bacterial Proteins metabolism, Chickens, Endo-1,4-beta Xylanases genetics, Endo-1,4-beta Xylanases metabolism, Enzyme Stability, Half-Life, Hot Temperature, Hydrogen-Ion Concentration, Kinetics, Molecular Sequence Data, Molecular Weight, Phylogeny, Poultry, Soil, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Substrate Specificity, Actinomycetales enzymology, Bacterial Proteins isolation & purification, Endo-1,4-beta Xylanases isolation & purification, RNA, Ribosomal, 16S biosynthesis, Xylans metabolism
- Abstract
An extracellular thermostable xylanase from a newly isolated thermophilic Actinomadura sp. strain Cpt20 was purified and characterized. Based on matrix-assisted laser desorption-ionization time-of-flight mass spectrometry analysis, the purified enzyme is a monomer with a molecular mass of 20,110.13 Da. The 19 residue N-terminal sequence of the enzyme showed 84% homology with those of actinomycete endoxylanases. The optimum pH and temperature values for xylanase activity were pH 10 and 80 °C, respectively. This xylanase was stable within a pH range of 5-10 and up to a temperature of 90 °C. It showed high thermostability at 60 °C for 5 days and half-life times at 90 °C and 100 °C were 2 and 1 h, respectively. The xylanase was specific for xylans, showing higher specific activity on soluble oat-spelt xylan followed by beechwood xylan. This enzyme obeyed the Michaelis-Menten kinetics, with the K (m) and k (cat) values being 1.55 mg soluble oat-spelt xylan/ml and 388 min(-1), respectively. While the xylanase from Actinomadura sp. Cpt20 was activated by Mn(2+), Ca(2+), and Cu(2+), it was, strongly inhibited by Hg(2+), Zn(2+), and Ba(2+). These properties make this enzyme a potential candidate for future use in biotechnological applications particularly in the pulp and paper industry.
- Published
- 2012
- Full Text
- View/download PDF
29. Congenital craniopharyngioma: a case report and literature review.
- Author
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Chentli F, Belhimer F, Kessaci F, and Mansouri B
- Subjects
- Craniopharyngioma congenital, Craniopharyngioma surgery, Fatal Outcome, Female, Humans, Hydrocephalus congenital, Hydrocephalus diagnosis, Hydrocephalus surgery, Infant, Magnetic Resonance Imaging, Pituitary Neoplasms congenital, Pituitary Neoplasms surgery, Tomography, X-Ray Computed, Craniopharyngioma diagnosis, Pituitary Neoplasms diagnosis
- Abstract
Introduction: Although craniopharyngiomas are congenital tumors, they are rarely diagnosed in the prenatal or early neonatal period. Sometimes they are very large, debilitating and life-threatening, as in the case discussed here., Observation: A 21-month-old girl was referred for craniopharyngioma that had been diagnosed at 5 months because of neurologic complications. The pregnancy and birth were considered to be unremarkable. The birth weight was 4 kg, length 53 cm, head circumference 38 cm (n=35±1). Brain CT revealed active hydrocephalus caused by a very large solid, cystic and calcified supra sellar mass. MRI confirmed the process measuring 5 cm in height, multidirectional, diving into pituitary sella, displacing the brainstem. After several resections and reservoir drainage, the patient was blind, hemiparetic and she convulsed frequently. The patient died when she was 2., Conclusion: The large head circumference at birth, the size of the tumor, blindness, and hemiparesis observed before the age of 5 months suggested an antenatal process unnoticed because of inadequate gestational monitoring.
- Published
- 2012
- Full Text
- View/download PDF
30. GC/MS analysis and antimicrobial activity of the essential oil of fresh leaves of Eucalytus globulus, and leaves and stems of Smyrnium olusatrum from Constantine (Algeria).
- Author
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Daroui-Mokaddem H, Kabouche A, Bouacha M, Soumati B, El-Azzouny A, Bruneau C, and Kabouche Z
- Subjects
- Algeria, Gas Chromatography-Mass Spectrometry, Microbial Sensitivity Tests, Oils, Volatile isolation & purification, Plant Leaves chemistry, Plant Stems chemistry, Anti-Infective Agents isolation & purification, Apiaceae chemistry, Eucalyptus chemistry, Oils, Volatile chemistry
- Abstract
The essential oils of fresh leaves of Eucalyptus globulus L. (Myrtaceae), and leaves and stems of Smyrnium olusatrum L. (Apiaceae), obtained by hydrodistillation in a Clevenger-type apparatus, were analyzed by GC/MS. Twenty compounds were characterized, representing 98.3% of the essential oil of E. globulus, with 1,8-cineole (48.6%), globulol (10.9%), trans-pinocarveol (10.7%), and alpha-terpineol (6.6%) as main components, while thirty-three compounds were characterized, representing 94.3% of the essential oil of S. olusatrum, with sabinene (27.1%), curzerene (13.7%), methyl-1-benzyl-2-oxocyclooctane carboxylate (12.3%), alpha-pinene (7.2%), cryptone (7.1%) and beta-pinene (5.7%) as the major components. The essential oils of E. globulus and S. olusatrum were tested against a wide range of fungal and bacterial strains. Both oils showed significant antimicrobial activity.
- Published
- 2010
31. Effects of Ramadan fasting on physical performance and metabolic, hormonal, and inflammatory parameters in middle-distance runners.
- Author
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Chennaoui M, Desgorces F, Drogou C, Boudjemaa B, Tomaszewski A, Depiesse F, Burnat P, Chalabi H, and Gomez-Merino D
- Subjects
- Adult, Affect, Epinephrine blood, Fatigue metabolism, Fatigue physiopathology, Hormones blood, Humans, Hydrocortisone metabolism, Interleukin-6 blood, Melatonin blood, Norepinephrine blood, Nutritional Status, Saliva metabolism, Sleep, Sleep Wake Disorders metabolism, Sleep Wake Disorders physiopathology, Surveys and Questionnaires, Task Performance and Analysis, Testosterone metabolism, Time Factors, Young Adult, Athletic Performance, Energy Metabolism, Fasting, Hormones metabolism, Inflammation Mediators blood, Islam, Running
- Abstract
The Ramadan fasting (RF) period is associated with changes in sleep habits and increased sleepiness, which may affect physical performance in athletes, and may induce metabolic, hormonal, and inflammatory disturbances. In 8 middle-distance athletes (25.0 +/- 1.3 years), a maximal aerobic velocity (MAV) test was performed 5 days before RF (day -5), and on days 7 and 21 of RF. The same days, saliva samples were collected to determine cortisol and testosterone concentrations before and after the MAV test. Blood samples were collected before RF (P1), at the end of RF (P2), and 1 week post RF (P3). Plasma levels of interleukin (IL)-6, a mediator of sleepiness and energy availability, were determined. We also evaluated changes in metabolic and hormonal parameters, mood state, and nutritional and sleep profiles. During RF, mean body mass and body fat did not statistically change. Compared with day -5, MAV values decreased at days 7 and 21 (p < 0.05, respectively), while testosterone/cortisol ratio values did not change significantly. Nocturnal sleep time and energy intake were lower at day 21 than before RF (day 0/P1) (p < 0.05). At the end of RF (day 31), the fatigue score on the Profile of Mood States questionnaire was increased (p < 0.001). For P2 vs. P1, IL-6 was increased (1.19 +/- 0.25 vs. 0.51 +/- 0.13 pg.mL-1; p < 0.05), melatonin levels were decreased (p < 0.05), and adrenalin and noradrenalin were increased (p < 0.01 and p < 0.001, respectively). At 7 days post RF, all parameters recovered to pre-RF values. In conclusion, RF is accompanied by significant metabolic, hormonal, and inflammatory changes. Sleep disturbances, energy deficiency, and fatigue during RF may decrease physical performance in Muslim athletes who maintain training. Reduction of work load and (or) daytime napping may represent adequate strategies to counteract RF effects for Muslim athletes.
- Published
- 2009
- Full Text
- View/download PDF
32. [Infarction in patients aged over 70. Apropos of 194 patients].
- Author
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Beard T, Carrié D, Boudjemaa B, Ferrières J, Delay M, and Bernadet P
- Subjects
- Aged, Aged, 80 and over, Aging, Angioplasty, Female, Follow-Up Studies, Hospitalization, Humans, Male, Myocardial Infarction mortality, Myocardial Infarction therapy, Risk Factors, Surveys and Questionnaires, Thrombolytic Therapy, Treatment Outcome, Myocardial Infarction epidemiology
- Abstract
Among 498 patients hospitalised for myocardial infarction during a three year period, 194 (39%) were aged over 70 (mean age: 78.6 +/- 6), including 99 women and 95 men. Comparison of this group of patients with those aged under 70 showed a significantly higher hospital mortality (17.5% v. 6.5%) (p < 0.01) and a higher acute complication rate (60.8% v. 23.7% (p < 0.01), in particular after the age of 75. Twenty-eight patients were treated by thrombolysis (14.4% v. 50.6%) (p < 0.05), with a 79.2% patency rate in follow-up angiography at 48 h, and only one non-fatal hemorrhagic complication. Eighty-six patients were investigated by coronary arteriography (44.9% v. 87.2% (p < 0.05) without any complication. Mean ejection fraction was 57.3 +/- 13.5%. Fifty patients were treated by angioplasty (24.6% v. 57%) (p < 0.01) including 15 during the acute phase, with primary success in 40 of them (80%). Ten patients underwent coronary bypass following their infarction (5.1% v. 6.25%) (NS) with two per- or postoperative deaths (20%). Follow-up study revealed high secondary mortality with an overall survival rate at one year of 59.6% v. 81% in patients aged under 70 (p < 0.01). In total, infarction in the elderly is characterised by high mortality and morbidity as compared with infarctions in patients aged under 70, and requires active management during the acute phase, assessed according to the physiological status and age of the patient.
- Published
- 1994
33. [Production of oxygen free radicals in myocardial infarction treated by thrombolysis. Analysis of glutathione peroxidase, superoxide dismutase and malondialdehyde].
- Author
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Béard T, Carrié D, Boyer MJ, Boudjemaa B, Ferrières J, Delay M, Bernadet P, and Thouvenot JP
- Subjects
- Adult, Aged, Erythrocytes enzymology, Female, Free Radicals, Humans, Male, Middle Aged, Myocardial Infarction blood, Myocardial Infarction drug therapy, Selenium blood, Thrombolytic Therapy methods, Fibrinolytic Agents therapeutic use, Glutathione Peroxidase blood, Malondialdehyde blood, Myocardial Infarction metabolism, Oxygen metabolism, Superoxide Dismutase blood
- Abstract
Many enzyme systems such as glutathione peroxidase (GPx) or superoxide dismutase (SOD) neutralise the oxygen derived free radicals produced during myocardial reperfusion by thrombolysis. Erythrocytic SOD, plasma and erythrocytic GPx and their cofactor selenium, substances reacting with thiobarbituric acid (TBARS) were analysed by repeated sampling between T0 and 48 hours in 24 patients treated by thrombolysis for acute myocardial infarction. Angiographic control was undertaken systematically between 60 and 180 minutes after initiating thrombolytic therapy: 18 patients had a patent vessel and 6 patients had an occluded vessel recanalised in 5 cases by angioplasty. Biological analysis was performed in the 23 patients successfully revascularised by thrombolysis, eventually completed by angioplasty. The plasma GPx decreased non-significantly between T0 and 2 hours from 246.8 +/- 53.3 to 233 +/- 39 U/ml with a significant increase between 2 and 48 hours from 233 +/- 39.2 to 294 +/- 76 U/ml, whereas the erythrocytic GPx rose significantly and constantly between T0 and 48 hours from 34.8 +/- 7.1 to 37.6 +/- 7.5 U/gHb with significant consumption of selenium between T0 and 4 hours from 81.2 +/- 14 to 68.5 +/- 12.6 micrograms/l. The erythrocytic SOD increased significantly between T0 and 48 hours from 318.9 +/- 40.8 to 337 +/- 59 U/gHb. Finally, the analysis of plasma TBARS showed a non-significant rise between T0 and 30 minutes from 1.59 +/- 0.30 to 1.71 +/- 1.43 mm/l with a return to the basic line values after about 2 hours. These results show a significant increase in the activity of enzymes protecting against the liberation of oxygen free radicals, such as erythrocyte or plasma GPx and erythrocyte SOD between T0 and 48 hours with consumption of selenium, cofactor of GPx, and an increase in circulating lipid peroxydes in acute myocardial infarction treated by thrombolysis. They also illustrate the oxidative stress which occurs in this situation.
- Published
- 1994
34. [Value of continuous measurement of mixed venous oxygen saturation (SVO2) during coronary angioplasty].
- Author
-
Carrié D, Boudjemaa B, Derbel F, Ferrières J, Delay M, and Bernadet P
- Subjects
- Adult, Aged, Coronary Disease blood, Coronary Disease physiopathology, Female, Hemodynamics, Humans, Male, Middle Aged, Monitoring, Physiologic, Oximetry, Stroke Volume, Veins, Ventricular Function, Left, Angioplasty, Balloon, Coronary, Coronary Disease therapy, Oxygen blood
- Abstract
Mixed venous oxygen saturation (SVO2) is an haemodynamic parameter of cardiovascular function. The object of this study was to measure SVO2 during percutaneous transluminal coronary angioplasty (PTCA) with prolonged balloon inflation in order to evaluate haemodynamic tolerance more precisely in two groups of patients. Twenty-six patients undergoing PTCA were divided into two groups: Group I, N = 15, with single vessel disease and good left ventricular function (EF: 61.63 +/- 10.1%); Group II, N = 11, with triple vessel disease and poor left ventricular function (EF: 48.05 +/- 14%; p < 0.05). Continuous monitoring of SVO2 with an oximetrix fiber optic catheter was performed in all patients during PTCA. Irrespective of the duration of balloon inflation, a significant correlation was observed between the changes in cardiac output and VSO2. Given that arterial oxygen pressure, global oxygen consumption and haemoglobin concentrations remained constant during balloon inflation, SVO2 was an indicator of cardiac output.
- Published
- 1993
35. [Simultaneous thrombosis of the left anterior interventricular and right coronary arteries in a 27 year-old patient with protein S deficiency].
- Author
-
Carrié D, Béard T, Sié P, Boudjemaa B, Delay M, and Bernadet P
- Subjects
- Adult, Angioplasty, Balloon, Coronary, Blood Coagulation Tests, Coronary Angiography, Coronary Thrombosis therapy, Humans, Male, Myocardial Infarction therapy, Coronary Thrombosis etiology, Myocardial Infarction etiology, Protein S Deficiency
- Abstract
The authors report a case of myocardial infarction in a 27 year old patient by simultaneous thrombosis of the left anterior descending and right coronary arteries in an angiographically normal coronary circulation. The young age of the patient, the absence of the usual risk factors and a normal angiographic network after arterial recanalisation by angioplasty led to the search for a risk factor of thrombosis. This showed a qualitative deficiency of protein S and the absence of any other abnormality of coagulation or fibrinolysis. This case raises the question of a causal relationship between a hereditary protein S deficiency and thrombotic arterial occlusion.
- Published
- 1993
36. [Acute severe coxsackie virus B myocarditis of pseudonecrotic form. Apropos of 2 cases].
- Author
-
Beard T, Boudjemaa B, Carrié D, Chakra G, Ferrières J, Delay M, and Bernadet P
- Subjects
- Acute Disease, Adult, Female, Humans, Male, Necrosis, Coxsackievirus Infections, Enterovirus B, Human, Myocarditis microbiology
- Abstract
This study reports two cases of acute severe Coxsackie virus B4 myocarditis in which the immediate clinical signs suggested the acute phase of myocardial infarction, apparently antero-lateral in the first case in a context of cardiogenic shock and infero-lateral in the second case, in the context of acute pulmonary edema. Both cases were characterized by the severity of the initial signs. Numerous other cases of acute Coxsackie virus B myocarditis, simulating myocardial infarction, have been reported in the literature and these contexts deserve to be recognized earlier as they call for specific treatment. The immediate outcome was favorable in both cases but required massive cardiological intensive care in the first patient. Long term follow-up was excellent.
- Published
- 1993
37. [Systematic cardiovascular evaluation and hypercholesterolemia. Results in 200 asymptomatic patients].
- Author
-
Ferrières J, Denat M, Delay M, Carrié D, Boudjemaa B, Douste-Blazy P, and Bernadet P
- Subjects
- Adult, Aged, Aging, Constriction, Pathologic prevention & control, Coronary Angiography, Exercise Test, Female, Humans, Hypercholesterolemia diagnostic imaging, Male, Mass Screening, Middle Aged, Radionuclide Imaging, Ultrasonography, Arteriosclerosis prevention & control, Carotid Artery Diseases prevention & control, Coronary Artery Disease prevention & control, Hypercholesterolemia complications
- Abstract
This study reports the results of routine evaluation to detect coronary and carotid atherosclerosis in 200 asymptomatic and hypercholesterolemic patients (48 +/- 10 years: 72.5% men). All patients underwent physical examination, blood lipid profile, an exercise test and cervical echo-doppler. If the exercise electrocardiogram was abnormal, a thallium isotope scan and/or coronary arteriography were performed. Hypercholesterolemia was severe (3.03 +/- 0.52 g/l). 77.5% of patients had pure hypercholesterolemia. Carotid atherosclerosis in the form of plaque (27.5%) or stenosis (3.5%) was found in 31% of patients. This carotid atheroma was commoner in older patients (51.9 +/- 9 years as against 47 +/- 10 years, p < 0.01). Twenty patients (10%) had electrical signs of ischemia provoked by exercise. Six of them had a normal thallium isotope scan and did not undergo coronary arteriography. Coronary arteriography was abnormal in 10 patients (5%): 7 had stenotic lesions and 3 showed evidence of spasm during the methylergometrine test. In total, the hypercholesterolemic patients investigated here were characterised by subclinical atherosclerosis which was frequent but certainly underestimated by non-invasive studies. The existence of an atherosclerotic lesion is an additional argument in favour of starting cholesterol-lowering treatment.
- Published
- 1993
38. [Study of left ventricular diastolic function using pulsed Doppler in myocardial infarct in hypertensive subjects].
- Author
-
Boudjemaa B, Carrie D, Granier P, Douste-Blazy MY, Beard T, Galinier F, and Bernadet P
- Subjects
- Aged, Diastole, Heart Ventricles physiopathology, Humans, Hypertension complications, Middle Aged, Myocardial Infarction complications, Echocardiography, Doppler, Hypertension physiopathology, Myocardial Infarction physiopathology
- Abstract
To determine if impairment of left ventricular filling is influenced by acute myocardial infarction in patients with arterial hypertension, left ventricular diastolic function was assessed by pulsed doppler echocardiography in 46 patients (pts) subdivided into four groups (Gr): G.1 (n = 12 pts) with acute myocardial infarction and hypertensive heart disease. G.2 (n = 12 pts) acute myocardial infarction without arterial hypertension. G.3 (n = 10 pts) arterial hypertension without history of coronary artery disease. G.4 (n = 12 pts) healthy subjects. Coronary angiography and left ventricular cineangiogram was performed in 24 pts (G.1 + G.2). Peak mitral flow velocity (cm/s) in early diastole (E), atrial systole (A), A/E and int A/int E ratios were measured by pulsed doppler. Age and heart rate were statistically similar in all groups. No difference was found among G.1 and G.2 in ejection fraction, and left ventricular segmental kinetic. (tables; see text) Conclusion left ventricular filling is impaired in pts with arterial hypertension and in pts with acute myocardial infarction; acute myocardial infarction increase the impairment of left ventricular diastolic function in pts with hypertensive heart disease.
- Published
- 1989
39. [Subungual glomus tumors. Apropos of 2 cases].
- Author
-
Boudjemaa B, Glock Y, Boccalon H, Ginestet MC, Puel P, Joffre F, and Duboucher C
- Subjects
- Angiography, Female, Humans, Middle Aged, Nails, Fingers blood supply, Glomus Tumor diagnosis
- Abstract
Glomus tumours are uncommon, though not exceptional, benign growths developed from the constituents of the "neuromyoarterial glomus" initially described by Masson. Two cases of subungual glomus tumours of the hand in middle-aged women are reported. In spite of characteristic symptoms, with paroxysmal episodes of pain triggered off by cold and the most minute traumas, and of the finding in both cases of a violine++ tumour under the nail, the condition was belatedly diagnosed (7 and 27 years respectively after the onset of symptoms). Diagnosis rested not so much on standard radiography, which showed erosion of the distal phalanx in both patients, as on arteriography of the hand which displayed a small vascular pool at the arterial stage. Tumoral excision was successful.
- Published
- 1987
40. [Thrombosis of the superior vena cava disclosing Behçet's disease].
- Author
-
Boudjemaa B, Glock Y, Roux D, Bierme R, Puel P, and Bentounsi A
- Subjects
- Adult, Humans, Male, Behcet Syndrome complications, Superior Vena Cava Syndrome complications
- Abstract
The authors report the case of a 29 year old North African patient with Behçet's disease presenting with sudden thrombosis of the superior vena cava. Venous disorders are the fourth major sign of this disease. Although superficial thrombophlebitis is a common presenting sign, caval thrombosis is rare and usually occurs after several years' evolution. Superior vena caval thrombosis may be life threatening due to complications such as pulmonary embolism and haemoptysis. The anatomical substrate of this form of vascular disease is the same as that of the other visceral lesions of Behçet's disease: predominantly venous vasculitis with perivascularitis and secondary thrombosis. The pathogenesis of this thrombotic diathesis is discussed.
- Published
- 1986
41. [Unstable angina in patients over 70 years of age].
- Author
-
Carrie D, Boudjemaa B, Fajadet J, and Bernadet P
- Subjects
- Aged, Aged, 80 and over, Angioplasty, Balloon, Coronary Angiography, Female, Follow-Up Studies, Hemodynamics, Humans, Male, Risk Factors, Angina Pectoris, Angina, Unstable complications, Angina, Unstable therapy
- Abstract
Between October, 1985 and June, 1987, 125 patients aged 70 years or more were admitted to the Cardiology Department of Purpan Hospital, Toulouse for unstable angina pectoris. 107 of these patients have been followed up, i.e.: 76 men and 31 women aged from 70 to 85 years (mean 74.5 +/- 3.2 years). 49 patients (46 p. 100) had angina at rest of the intermediate syndrome type; 46 (43 p. 100) had rapidly progressive effort angina, and 12 (11 p. 100) had effort angina de novo. The patients' general condition was preserved in 85 p. 100 of the cases and altered in 15 p. 100. ECG was normal in only 10 p. 100 of the patients; it showed signs of established ischaemia in 70 p. 100 of the cases and sequelae of infarction in 23 p. 100. The mean cardiothoracic ration was 49.9 +/- 4.8 p. 100. The ejection fraction was 62 +/- 14.6 p. 100, the end-diastolic volume 86.9 +/- 32.2 ml/m2 and the left ventricular end-diastolic pressure 15.8 +/- 7.2 mmHg. 69 patients (64.5 p. 100) had calcifications in their coronary arteries. At coronary arteriography 21 patients (19.6 p. 100) showed stenosis of the main stem, 11 patients (10.3 p. 100) had a single vessel disease, 28 (26.2 p. 100) a two-vessel disease and 47 (43.9 p. 100) a three-vessel disease. Treatment was medical in 41 patients (38.3 p. 100) and surgical in 44 patients (41.12 p. 100); transluminal coronary angioplasty (TCA) was performed in 23 patients (21.5 p. 100).(ABSTRACT TRUNCATED AT 250 WORDS)
- Published
- 1988
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