1. [Apoptosis of mononuclear cells and dead leukocytes in venous blood of septic patients].
- Author
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Borovkova IV, Khvatov VB, Aleksandrova IV, Reĭ SI, Il'inskiĭ ME, and Abakumov MM
- Subjects
- Adult, Female, Humans, Leukocyte Count, Lymphocytes immunology, Lymphocytes pathology, Male, Middle Aged, Prognosis, Sepsis blood, Severity of Illness Index, fas Receptor immunology, Apoptosis physiology, Leukocytes, Mononuclear pathology, Sepsis pathology
- Abstract
Apoptosis of mononuclear cells, dead leukocyte and CD95+ lymphocytes content in venous blood of 15 patients were evaluated by flow cytometry within 2-3 day after diagnosis of sepsis. The number of CD95+ lymphocytes increased in 40% of the cases and that of lymphocytes expressing Fas receptor decreased in 27%. The number of mononuclear cells in venous blood increased 7 times compared with physiological norm; this rise was a reliable predictor of the unfavourable outcome of the disease. Elimination of dead leukocytes by granulocytophoresis produced good therapeutic result.
- Published
- 2009