734 results on '"Borhani-Haghighi, Afshin"'
Search Results
2. Machine learning-based Cerebral Venous Thrombosis diagnosis with clinical data
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Namjoo-Moghadam, Ali, Abedi, Vida, Avula, Venkatesh, Ashjazadeh, Nahid, Hooshmandi, Etrat, Abedinpour, Niloufar, Rahimian, Zahra, Borhani-Haghighi, Afshin, and Zand, Ramin
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- 2024
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3. A comprehensive review on the neuroprotective potential of resveratrol in ischemic stroke
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Owjfard, Maryam, Rahimian, Zahra, Karimi, Farzaneh, Borhani-Haghighi, Afshin, and Mallahzadeh, Arashk
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- 2024
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4. Outcome predictors in anterior and posterior ischemic strokes: a study based on the Iranian SITS registry
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Jalali, Nazanin, Sadeghi Hokmabadi, Elyar, Ghoreishi, Abdoreza, Sariaslan, Payam, Rafie, Shahram, Borhani-Haghighi, Afshin, Moghadam Ahmadi, Amir, Azin, Hossein, Vakilian, Alireza, Khalili, Parvin, and Farhoudi, Mehdi
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- 2023
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5. From Hair to the Brain: The Short-Term Therapeutic Potential of Human Hair Follicle-Derived Stem Cells and Their Conditioned Medium in a Rat Model of Stroke
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Karimi-Haghighi, Saeideh, Pandamooz, Sareh, Jurek, Benjamin, Fattahi, Sadegh, Safari, Anahid, Azarpira, Negar, Dianatpour, Mehdi, Hooshmandi, Etrat, Bayat, Mahnaz, Owjfard, Maryam, Zafarmand, Seyedeh Shaghayegh, Mostaghel, Mandana, Mousavi, Seyedeh Maryam, Jashire Nezhad, Nahid, Eraghi, Vida, Fadakar, Nima, Rahimi Jaberi, Abbas, Garcia-Esperon, Carlos, Spratt, Neil, Levi, Christopher, Salehi, Mohammad Saied, and Borhani-Haghighi, Afshin
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- 2023
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6. Mechanism of action and neuroprotective role of nicorandil in ischemic stroke
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Owjfard, Maryam, Rahmani, Negin, Mallahzadeh, Arashk, Bayat, Mahnaz, Borhani-Haghighi, Afshin, Karimi, Farzaneh, and Namavar, Mohammad Reza
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- 2024
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7. Safety and Outcomes of Intravenous Thrombolytic Therapy in Ischemic Stroke Patients with COVID-19: CASCADE Initiative
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Sasanejad, Payam, Afshar Hezarkhani, Leila, Arsang-Jang, Shahram, Tsivgoulis, Georgios, Ghoreishi, Abdoreza, Barlinn, Kristian, Rahmig, Jan, Farhoudi, Mehdi, Sadeghi Hokmabadi, Elyar, Borhani-Haghighi, Afshin, Sariaslani, Payam, Sharifi-Razavi, Athena, Ghandehari, Kavian, Khosravi, Alireza, Smith, Craig, Nilanont, Yongchai, Akbari, Yama, Nguyen, Thanh N, Bersano, Anna, Yassi, Nawaf, Yoshimoto, Takeshi, Lattanzi, Simona, Gupta, Animesh, Zand, Ramin, Rafie, Shahram, Pourandokht Mousavian, Seyede, Reza Shahsavaripour, Mohammad, Amini, Shahram, Kamenova, Saltanat U, Kondybayeva, Aida, Zhanuzakov, Murat, Macri, Elizabeth M, Nobleza, Christa O'Hana S, Ruland, Sean, Cervantes-Arslanian, Anna M, Desai, Masoom J, Ranta, Annemarei, Moghadam Ahmadi, Amir, Rostamihosseinkhani, Mahtab, Foroughi, Razieh, Hooshmandi, Etrat, Akhoundi, Fahimeh H, Shuaib, Ashfaq, Liebeskind, David S, Siegler, James, Romano, Jose G, Mayer, Stephan A, Bavarsad Shahripour, Reza, Zamani, Babak, Woolsey, Amadene, Fazli, Yasaman, Mojtaba, Khazaei, Isaac, Christian F, Biller, Jose, Di Napoli, Mario, and Azarpazhooh, M Reza
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Biomedical and Clinical Sciences ,Clinical Sciences ,Neurosciences ,Stroke ,Brain Disorders ,Clinical Research ,Good Health and Well Being ,Aged ,Aged ,80 and over ,COVID-19 ,Disability Evaluation ,Europe ,Female ,Fibrinolytic Agents ,Hospital Mortality ,Humans ,Infusions ,Intravenous ,Intracranial Hemorrhages ,Iran ,Ischemic Stroke ,Male ,Middle Aged ,Risk Assessment ,Risk Factors ,Thrombolytic Therapy ,Time Factors ,Treatment Outcome ,COVID 19 ,Thrombolytic therapy ,Longitudinal study ,Safety ,Outcomes ,Disability ,Stroke severity ,death ,Neurology & Neurosurgery ,Clinical sciences - Abstract
BackgroundThere is little information regarding the safety of intravenous tissue plasminogen activator (IV-tPA) in patients with stroke and COVID-19.MethodsThis multicenter study included consecutive stroke patients with and without COVID-19 treated with IV-tPA between February 18, 2019, to December 31, 2020, at 9 centers participating in the CASCADE initiative. Clinical outcomes included modified Rankin Scale (mRS) at hospital discharge, in-hospital mortality, the rate of hemorrhagic transformation. Using Bayesian multiple regression and after adjusting for variables with significant value in univariable analysis, we reported the posterior adjusted odds ratio (OR, with 95% Credible Intervals [CrI]) of the main outcomes.ResultsA total of 545 stroke patients, including 101 patients with COVID-19 were evaluated. Patients with COVID-19 had a more severe stroke at admission. In the study cohort, 85 (15.9%) patients had a hemorrhagic transformation, and 72 (13.1%) died in the hospital. After adjustment for confounding variables, discharge mRS score ≥2 (OR: 0.73, 95% CrI: 0.16, 3.05), in-hospital mortality (OR: 2.06, 95% CrI: 0.76, 5.53), and hemorrhagic transformation (OR: 1.514, 95% CrI: 0.66, 3.31) were similar in COVID-19 and non COVID-19 patients. High-sensitivity C reactive protein level was a predictor of hemorrhagic transformation in all cases (OR:1.01, 95%CI: 1.0026, 1.018), including those with COVID-19 (OR:1.024, 95%CI:1.002, 1.054).ConclusionIV-tPA treatment in patients with acute ischemic stroke and COVID-19 was not associated with an increased risk of disability, mortality, and hemorrhagic transformation compared to those without COVID-19. IV-tPA should continue to be considered as the standard of care in patients with hyper acute stroke and COVID-19.
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- 2021
8. Neuroinflammatory Response in Reward-Associated Psychostimulants and Opioids: A Review
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Karimi-Haghighi, Saeideh, Chavoshinezhad, Sara, Mozafari, Roghayeh, Noorbakhsh, Farshid, Borhani-Haghighi, Afshin, and Haghparast, Abbas
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- 2023
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9. Improving Swallowing Function and Ability in Post Stroke Dysphagia: A Randomized Clinical Trial
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Farpour, Sima, Asadi-Shekaari, Majid, Borhani Haghighi, Afshin, and Farpour, Hamid Reza
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- 2023
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10. Combined use of hair follicle stem cells and CEPO (carbamylated erythropoietin)-Fc in a rat model of chronic cerebral hypoperfusion: A behavioral, electrophysiological, and molecular study
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Hooshmandi, Etrat, Akbari, Somayeh, Pandamooz, Sareh, Ghobadi, Mojtaba, Ghasemi, Rasoul, Maghsoudi, Nader, Rai, Sachchida Nand, Borhani-Haghighi, Afshin, Salehi, Mohammad Saied, Azarpira, Negar, YousefiNejad, Amirhossein, Haghani, Masoud, and Bayat, Mahnaz
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- 2023
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11. Evaluating cognitive impairment in the early stages of Parkinson’s disease using the Cambridge brain sciences-cognitive platform
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Hosseini, Maryam, Borhani-Haghighi, Afshin, Petramfar, Peyman, Foroughi, Amin Abolhasani, Ostovan, Vahid Reza, and Nami, Mohammad
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- 2023
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12. Short-term beneficial effects of human dental pulp stem cells and their secretome in a rat model of mild ischemic stroke
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Jashire Nezhad, Nahid, Safari, Anahid, Namavar, Mohammad Reza, Nami, Mohammad, Karimi-Haghighi, Saeideh, Pandamooz, Sareh, Dianatpour, Mehdi, Azarpira, Negar, Khodabandeh, Zahra, Zare, Shahrokh, Hooshmandi, Etrat, Bayat, Mahnaz, Owjfard, Maryam, Zafarmand, Seyedeh Shaghayegh, Fadakar, Nima, Jaberi, Abbas Rahimi, Salehi, Mohammad Saied, and Borhani-Haghighi, Afshin
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- 2023
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13. Abstract 17744: Intracranial Atherosclerosis Disease (ICAD) and Risk of Cognitive Impairment and Dementia: Systematic Review and Meta-Analysis
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Sabayan, Behnam, Goudarzi, Roham, Borhani-Haghighi, Afshin, Ji, Yuekai, Olson-Bullis, Barbara, and Sedaghat, Sanaz
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- 2023
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14. Stroke Care Trends During COVID-19 Pandemic in Zanjan Province, Iran. From the CASCADE Initiative: Statistical Analysis Plan and Preliminary Results
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Ghoreishi, Abdoreza, Arsang-Jang, Shahram, Sabaa-Ayoun, Ziad, Yassi, Nawaf, Sylaja, PN, Akbari, Yama, Divani, Afshin A, Biller, Jose, Phan, Thanh, Steinwender, Sandy, Silver, Brian, Zand, Ramin, Bin Basri, Hamidon, Iqbal, Omer M, Ranta, Annemarei, Ruland, Sean, Macri, Elizabeth, Ma, Henry, Nguyen, Thanh N, Abootalebi, Shahram, Gupta, Animesh, Alet, Matias, Lattanzi, Simona, Desai, Masoom, Gagliardi, Rubens J, Girotra, Tarun, Inoue, Manabu, Yoshimoto, Takeshi, Isaac, Cristian Flavo, Mayer, Stephan A, Morovatdar, Negar, Nilanont, Yongchai, Nobleza, Christa O'Hana S, Saber, Hamidreza, Kamenova, Saltanat, Kondybayeva, Aida, Krupinski, Jerzy, Siegler, James E, Stranges, Saverio, Torbey, Michel T, Yorio, Diana, Zurrú, María Cristina, Rubinos, Clio Aracelli, Shahripour, Reza Bavarsad, Borhani-Haghighi, Afshin, Di Napoli, Mario, and Azarpazhooh, M Reza
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Stroke ,Brain Disorders ,Neurosciences ,Patient Safety ,Health and social care services research ,8.1 Organisation and delivery of services ,Good Health and Well Being ,Aged ,Aged ,80 and over ,Bayes Theorem ,Brain Ischemia ,COVID-19 ,Female ,Hospital Mortality ,Hospitalization ,Humans ,Interrupted Time Series Analysis ,Intracranial Hemorrhages ,Iran ,Length of Stay ,Male ,Middle Aged ,Outcome and Process Assessment ,Health Care ,Recovery of Function ,Thrombolytic Therapy ,Time Factors ,Time-to-Treatment ,Treatment Outcome ,Epidemiology ,Outcome ,Mortality ,Disability ,Stroke care ,Clinical Sciences ,Neurology & Neurosurgery ,Clinical sciences - Abstract
BackgroundThe emergence of the COVID-19 pandemic has significantly impacted global healthcare systems and this may affect stroke care and outcomes. This study examines the changes in stroke epidemiology and care during the COVID-19 pandemic in Zanjan Province, Iran.MethodsThis study is part of the CASCADE international initiative. From February 18, 2019, to July 18, 2020, we followed ischemic and hemorrhagic stroke hospitalization rates and outcomes in Valiasr Hospital, Zanjan, Iran. We used a Bayesian hierarchical model and an interrupted time series analysis (ITS) to identify changes in stroke hospitalization rate, baseline stroke severity [measured by the National Institutes of Health Stroke Scale (NIHSS)], disability [measured by the modified Rankin Scale (mRS)], presentation time (last seen normal to hospital presentation), thrombolytic therapy rate, median door-to-needle time, length of hospital stay, and in-hospital mortality. We compared in-hospital mortality between study periods using Cox-regression model.ResultsDuring the study period, 1,026 stroke patients were hospitalized. Stroke hospitalization rates per 100,000 population decreased from 68.09 before the pandemic to 44.50 during the pandemic, with a significant decline in both Bayesian [Beta: -1.034; Standard Error (SE): 0.22, 95% CrI: -1.48, -0.59] and ITS analysis (estimate: -1.03, SE = 0.24, p
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- 2020
15. Mortality-Related Risk Factors for Coronavirus Disease (COVID-19)-Associated Mucormycosis: a systematic review and meta-analysis
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Ostovan, Vahid Reza, Tabrizi, Reza, Bazrafshan, Hanieh, Bahrami, Zahra, Khazraei, Hajar, Khazraei, Samaneh, Borhani-Haghighi, Afshin, Moghadami, Mohsen, and Grant, Matthew
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- 2022
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16. Call to Action: SARS-CoV-2 and CerebrovAscular DisordErs (CASCADE).
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Abootalebi, Shahram, Aertker, Benjamin M, Andalibi, Mohammad Sobhan, Asdaghi, Negar, Aykac, Ozlem, Azarpazhooh, M Reza, Bahit, M Cecilia, Barlinn, Kristian, Basri, Hamidon, Shahripour, Reza Bavarsad, Bersano, Anna, Biller, Jose, Borhani-Haghighi, Afshin, Brown, Robert D, Campbell, Bruce Cv, Cruz-Flores, Salvador, De Silva, Deidre Anne, Di Napoli, Mario, Divani, Afshin A, Edgell, Randall C, Fifi, Johanna T, Ghoreishi, Abdoreza, Hirano, Teruyuki, Hong, Keun-Sik, Hsu, Chung Y, Huang, Josephine F, Inoue, Manabu, Jagolino, Amanda L, Kapral, Moira, Kee, Hoo Fan, Keser, Zafer, Khatri, Rakesh, Koga, Masatoshi, Krupinski, Jerzy, Liebeskind, David S, Liu, Liping, Ma, Henry, Maud, Alberto, McCullough, Louise D, Meyer, Dawn Matherne, Mifsud, Victoria, Morovatdar, Negar, Nilanont, Yongchai, Oxley, Thomas J, Özdemir, Atilla Özcan, Pandian, Jeyaraj, Pantoni, Leonardo, Papamitsakis, Nikolaos IH, Parry-Jones, Adrian, Phan, Thanh, Rodriguez, Gustavo, Romano, Jose G, Sabaa-Ayoun, Ziad, Saber, Hamidreza, Sasannezhad, Payam, Saver, Jeffrey L, Scharf, Eugene, Shuaib, Ashfaq, Silver, Brian, Singhal, Shaloo, Smith, Craig J, Stranges, Saverio, Sylaja, PN, Torbey, Michel, Toyoda, Kazunori, Tsivgoulis, Georgios, Wasay, Mohammad, Yassi, Nawaf, Yoshimoto, Takeshi, Zamani, Babak, and Zand, Ramin
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Humans ,Pneumonia ,Viral ,Coronavirus Infections ,Treatment Outcome ,Hospitalization ,Registries ,Incidence ,Hospital Mortality ,Risk Factors ,Retrospective Studies ,Prospective Studies ,Comorbidity ,Time Factors ,Stroke ,Healthcare Disparities ,Host-Pathogen Interactions ,Pandemics ,Interrupted Time Series Analysis ,Practice Patterns ,Physicians' ,Betacoronavirus ,COVID-19 ,SARS-CoV-2 ,Health policy ,Mortality ,National crisis ,Pandemic ,Pneumonia ,Viral ,Practice Patterns ,Physicians' ,Physicians ,Neurology & Neurosurgery ,Clinical Sciences ,Neurosciences - Abstract
Background and purposeThe novel severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), now named coronavirus disease 2019 (COVID-19), may change the risk of stroke through an enhanced systemic inflammatory response, hypercoagulable state, and endothelial damage in the cerebrovascular system. Moreover, due to the current pandemic, some countries have prioritized health resources towards COVID-19 management, making it more challenging to appropriately care for other potentially disabling and fatal diseases such as stroke. The aim of this study is to identify and describe changes in stroke epidemiological trends before, during, and after the COVID-19 pandemic.MethodsThis is an international, multicenter, hospital-based study on stroke incidence and outcomes during the COVID-19 pandemic. We will describe patterns in stroke management, stroke hospitalization rate, and stroke severity, subtype (ischemic/hemorrhagic), and outcomes (including in-hospital mortality) in 2020 during COVID-19 pandemic, comparing them with the corresponding data from 2018 and 2019, and subsequently 2021. We will also use an interrupted time series (ITS) analysis to assess the change in stroke hospitalization rates before, during, and after COVID-19, in each participating center.ConclusionThe proposed study will potentially enable us to better understand the changes in stroke care protocols, differential hospitalization rate, and severity of stroke, as it pertains to the COVID-19 pandemic. Ultimately, this will help guide clinical-based policies surrounding COVID-19 and other similar global pandemics to ensure that management of cerebrovascular comorbidity is appropriately prioritized during the global crisis. It will also guide public health guidelines for at-risk populations to reduce risks of complications from such comorbidities.
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- 2020
17. Endovascular Treatment of Cerebral Sinus Thrombosis
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Edgell, Randall C., Abdelsalam, Ahmed, Wasay, Mohammad, Borhani-Haghighi, Afshin, Tarsy, Daniel, Series Editor, Edgell, Randall C., editor, and M. Christopher, Kara, editor
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- 2022
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18. Oral Anticoagulants for Stroke Prevention in Atrial Fibrillation: A Systematic Review of Economic Evaluations
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Goudarzi, Zahra, Ghafari Darab, Mohsen, Vazin, Afsaneh, Hayatbakhsh, Amirreza, Karimzadeh, Iman, Jafari, Mojtaba, Keshavarz, Khosro, and Borhani-Haghighi, Afshin
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- 2023
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19. Is facial nerve palsy an early manifestation of COVID-19? A literature review
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Estakhr, Mehrdad, Tabrizi, Reza, Ghotbi, Zahra, Shahabi, Saeed, Habibzadeh, Adrina, Bashi, Ali, and Borhani-Haghighi, Afshin
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- 2022
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20. The Hospitalization Rate of Cerebral Venous Sinus Thrombosis before and during COVID-19 Pandemic Era: A Single-Center Retrospective Cohort Study
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Vasaghi Gharamaleki, Maryam, Habibagahi, Maryam, Hooshmandi, Etrat, Tabrizi, Reza, Arsang-Jang, Shahram, Barzegar, Zohreh, Fadakar, Nima, Reza Ostovan, Vahid, Rahimi-Jaberi, Abbas, Ashjazadeh, Nahid, Petramfar, Peyman, Poursadeghfard, Maryam, Izadi, Sadegh, Nazeri, Masoumeh, Bazrafshan, Hanieh, Bahrami, Zahra, Karimlu, Sedigheh, Shaghayegh Zafarmand, Seyedeh, Bayat, Mahnaz, Saied Salehi, Mohammad, Owjfard, Maryam, Karimi-Haghighi, Saeideh, Safari, Anahid, Shakibajahromi, Banafsheh, Lim Alvin Chew, Beng, Worral, Bradford B. g, Coutinho, Jonathan M., Garcia-Esperon, Carlos, Spratt, Neil, Levi, Christopher, Azarpazhooh, Mahmoud Reza, and Borhani-Haghighi, Afshin
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- 2022
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21. The Beneficial Potential of Genetically Modified Stem Cells in the Treatment of Stroke: a Review
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Salehi, Mohammad Saied, Safari, Anahid, Pandamooz, Sareh, Jurek, Benjamin, Hooshmandi, Etrat, Owjfard, Maryam, Bayat, Mahnaz, Zafarmand, Seyedeh Shaghayegh, Miyan, Jaleel A., and Borhani-Haghighi, Afshin
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- 2022
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22. Expression and diagnostic values of MIAT, H19, and NRON long non-coding RNAs in multiple sclerosis patients
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Amiri, Mehrnoosh, Mokhtari, Mohammad Javad, Bayat, Mahnaz, Safari, Anahid, Dianatpuor, Mehdi, Tabrizi, Reza, and Borhani-Haghighi, Afshin
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- 2022
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23. Therapeutic potential of hair follicle-derived stem cell intranasal transplantation in a rat model of ischemic stroke
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Mousavi, Seyedeh Maryam, Akbarpour, Bijan, Karimi-Haghighi, Saeideh, Pandamooz, Sareh, Belém-Filho, Ivaldo Jesus Almeida, Masís-Calvo, Marianella, Salimi, Haniye, Lashanizadegan, Ramin, Pouramini, Alireza, Owjfard, Maryam, Hooshmandi, Etrat, Bayat, Mahnaz, Zafarmand, Seyedeh Shaghayegh, Dianatpour, Mehdi, Salehi, Mohammad Saied, and Borhani-Haghighi, Afshin
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- 2022
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24. The Cerebrospinal Fluid Presentations of Neuro-Behçet Disease
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Borhani-Haghighi, Afshin, Tüzün, Erdem, editor, and Kürtüncü, Murat, editor
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- 2021
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25. Preconditioning with secretome of neural crest-derived stem cells enhanced neurotrophic expression in mesenchymal stem cells
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Karimi-Haghighi, Saeideh, Chavoshinezhad, Sara, Safari, Anahid, Razeghian-Jahromi, Iman, jamhiri, Iman, Khodabandeh, Zahra, Khajeh, Sahar, Zare, Shahrokh, Borhani-Haghighi, Afshin, Dianatpour, Mehdi, Pandamooz, Sareh, and Salehi, Mohammad Saied
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- 2022
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26. Association between Fok1 and TaqI polymorphisms of vitamin D receptor gene with the severity of stenosis and calcification in carotid bulb in patients with ischemic stroke
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Foroughinia, Farzaneh, Morovati, Najmeh, Safari, Anahid, Dianatpour, Mehdi, Jamhiri, Iman, Heydari, Seyed Taghi, Hooshmandi, Sedighe, and Borhani-Haghighi, Afshin
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- 2022
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27. The effects of action observation training as an add-on rehabilitation strategy on the walking ability of patients with chronic stroke
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Shamsi, Fatemeh, Nami, Mohammad, Aligholi, Hadi, Borhani-Haghighi, Afshin, Zahediannasb, Roohollah, Hekmatnia, Mahshid, and Karimi, Mohammad Taghi
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- 2022
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28. Quantitative EEG for the Monitoring of Walking Recovery in Chronic Stroke Patients Receiving Action Observation Training.
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Shamsi, Fatemeh, Aligholi, Hadi, Karimi, Mohammad Taghi, Borhani-Haghighi, Afshin, and Nami, Mohammad
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BODY-weight-supported treadmill training ,MOTION capture (Human mechanics) ,STROKE patients ,BRAIN function localization ,ELECTROENCEPHALOGRAPHY - Abstract
The current study aimed to evaluate the effects of action observation on the walking ability and oscillatory brain activity of chronic stroke patients. Fourteen chronic stroke patients were allocated randomly to the action observation (AO) or sham observation (SO) groups. Both groups received 12 sessions of intervention. Each session composed of 12 min of observational training, which depicted exercises for the experimental group but nature pictures for the sham group and 40 min of occupational therapy, which was the same for the both groups. Walking ability was assessed by a motion analysis system and brain activity was monitored using quantitative electroencephalography (QEEG) before and after the intervention. Brain asymmetry at alpha frequency, the percentage of stance phase, and step length showed significant changes in the AO group. Only the change in global alpha power was significantly correlated with the change in velocity after the intervention in AO group. Despite more improvements in walking and brain activity of patients in the AO group, our study failed to show significant correlations between the brain activity changes and functional improvements after the intervention, which might be mainly due to the small sample size in our study. Trial registration: IRCT20181014041333N1 [ABSTRACT FROM AUTHOR]
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- 2024
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29. Cerebral venous sinus thrombosis associated with COVID-19: a case series and literature review
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Ostovan, Vahid Reza, Foroughi, Razieh, Rostami, Mahtab, Almasi-Dooghaee, Mostafa, Esmaili, Manouchehr, Bidaki, Ali Akbar, Behzadi, Zahra, Farzadfard, Farzane, Marbooti, Hoda, Rahimi-Jaberi, Abbas, Poursadeghfard, Maryam, Fadakar, Nima, Bayat, Mahnaz, Owjfard, Maryam, Salehi, Mohammad Saied, Zafarmand, Seyedeh Shaghayegh, Mardi, Farzad, Safari, Anahid, Shahjouei, Shima, Mowla, Ashkan, Azarpazhooh, Mahmoud Reza, Zand, Ramin, Hooshmandi, Etrat, and Borhani-Haghighi, Afshin
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- 2021
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30. Outcomes of Cerebral Venous Thrombosis due to Vaccine-Induced Immune Thrombotic Thrombocytopenia After the Acute Phase
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van de Munckhof, Anita, Lindgren, Erik, Kleinig, Timothy J., Field, Thalia S., Cordonnier, Charlotte, Krzywicka, Katarzyna, Poli, Sven, Sánchez van Kammen, Mayte, Borhani-Haghighi, Afshin, Lemmens, Robin, Scutelnic, Adrian, Ciccone, Alfonso, Gattringer, Thomas, Wittstock, Matthias, Dizonno, Vanessa, Devroye, Annemie, Elkady, Ahmed, Günther, Albrecht, Cervera, Alvaro, Mengel, Annerose, Chew, Beng Lim Alvin, Buck, Brian, Zanferrari, Carla, Garcia-Esperon, Carlos, Jacobi, Christian, Soriano, Cristina, Michalski, Dominik, Zamani, Zohreh, Blacquiere, Dylan, Johansson, Elias, Cuadrado-Godia, Elisa, Vuillier, Fabrice, Bode, Felix J., Caparros, François, Maier, Frank, Tsivgoulis, Georgios, Katzberg, Hans D., Duan, Jiangang, Burrow, Jim, Pelz, Johann, Mbroh, Joshua, Oen, Joyce, Schouten, Judith, Zimmermann, Julian, Ng, Karl, Garambois, Katia, Petruzzellis, Marco, Carvalho Dias, Mariana, Ghiasian, Masoud, Romoli, Michele, Miranda, Miguel, Wronski, Miriam, Skjelland, Mona, Almasi-Dooghaee, Mostafa, Cuisenier, Pauline, Murphy, Seán, Timsit, Serge, Coutts, Shelagh B., Schönenberger, Silvia, Nagel, Simon, Hiltunen, Sini, Chatterton, Sophie, Cox, Thomas, Bartsch, Thorsten, Shaygannejad, Vahid, Mirzaasgari, Zahra, Middeldorp, Saskia, Levi, Marcel M., Kremer Hovinga, Johanna A., Jood, Katarina, Tatlisumak, Turgut, Putaala, Jukka, Heldner, Mirjam R., Arnold, Marcel, Aguiar de Sousa, Diana, Ferro, José M., and Coutinho, Jonathan M.
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- 2022
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31. COVID-19 Respiratory Illness and Subsequent Cerebrovascular Events, the Initial Iranian Experience
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Sabayan, Behnam, Moghadami, Mohsen, Assarzadegan, Farhad, Komachali, Sahar Hojjat-Anasri, Poorsaadat, Leila, Babaeepour, Zabihollah, Ebrahimzadeh, Seyed Amir, Hamidi, Ava, Hasheminejad, Zeinab Sadat, Mohammadi-Vosough, Elahe, Mirkarimi, Hamid Reza, Paybast, Sepideh, Rahimian, Nasrin, Safari, Anahid, Sepehrnia, Mersedeh, Nematollahi, Reza, Shahripour, Reza Bavarsad, Batra, Ayush, Sorond, Farzaneh, and Borhani-Haghighi, Afshin
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- 2021
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32. The impacts of anesthetic regimens on the middle cerebral artery occlusion outcomes in male rats
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Mousavi, Seyedeh Maryam, Karimi-Haghighi, Saeideh, Chavoshinezhad, Sara, Pandamooz, Sareh, Belém-Filho, Ivaldo Jesus Almeida, Keshavarz, Somaye, Bayat, Mahnaz, Hooshmandi, Etrat, Rahimi Jaberi, Abbas, Salehi, Mohammad Saied, and Borhani-Haghighi, Afshin
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- 2022
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33. Cerebral venous sinus thrombosis associated with SARS-CoV-2; a multinational case series
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Mowla, Ashkan, Shakibajahromi, Banafsheh, Shahjouei, Shima, Borhani-Haghighi, Afshin, Rahimian, Nasrin, Baharvahdat, Humain, Naderi, Soheil, Khorvash, Fariborz, Altafi, Davar, Ebrahimzadeh, Seyed Amir, Farahmand, Ghasem, Vaghefi Far, Alaleh, Sharma, Vijay K., Neshin, Saeideh Aghayari Sheikh, Tsivgoulis, Georgios, and Zand, Ramin
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- 2020
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34. Hookah Smoking: A Potentially Risk Factor for First-Ever Ischemic Stroke
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Tabrizi, Reza, Borhani-Haghighi, Afshin, Lankarani, Kamran B., Heydari, Seyed Taghi, Bayat, Mahnaz, Vakili, Sina, Maharlouei, Najmeh, Hassanzadeh, Jafar, Zafarmand, Seyedeh Shaghayegh, Owjfard, Maryam, Avan, Abolfazl, and Azarpazhooh, M. Reza
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- 2020
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35. Intracranial Atherosclerosis Disease (ICAD) Associated with Cognitive Impairment and Dementia: Systematic Review and Meta‐Analysis
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Sabayan, Behna, primary, Goudarzi, Roham, additional, Ji, Yuekai, additional, Borhani‐Haghighi, Afshin, additional, Olson‐Bullis, Barbara A, additional, Murray, Anne M, additional, and Sedaghat, Sanaz, additional
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- 2023
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36. The role of transcranial direct current stimulation in diminishing the risk of pneumonia in patients with dysphagia: A double-blinded randomized clinical trial
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Farpour, Sima, primary, Asadi-Shekaari, Majid, additional, Borhani-Haghighi, Afshin, additional, Farpour, Hamid Reza, additional, and Rostamihosseinkhani, Mahtab, additional
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- 2023
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37. Long non-coding RNA H19 expression and functional polymorphism rs217727 are linked to increased ischemic stroke risk
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Rezaei, Mohadese, Mokhtari, Mohammad Javad, Bayat, Mahnaz, Safari, Anahid, Dianatpuor, Mehdi, Tabrizi, Reza, Asadabadi, Tahereh, and Borhani-Haghighi, Afshin
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- 2021
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38. Asian Study of Cerebral Venous Thrombosis
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Wasay, Mohammad, Kaul, Subash, Menon, Bindu, Dai, Alper I., Saadatnia, Mohammad, Malik, Abdul, Khalifa, Ahmed, Borhani-Haghighi, Afshin, Mehndiratta, Manmohan, Khan, Maria, Bikash Bhowmik, Nimalendu, and Awan, Safia
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- 2019
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39. The effects of alpha-lipoic acid supplementation on fasting glucose and lipid profiles among patients with stroke: a systematic review and meta-analysis of randomized controlled trials
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Tabrizi, Reza, Borhani-Haghighi, Afshin, Mirhosseini, Naghmeh, Lankarani, Kamran B., Naghibzadeh-Tahami, Ahmad, Akbari, Maryam, Heydari, Seyed Taghi, Sangari, Mojgan, Kolahdooz, Fariba, Raygan, Fariba, and Asemi, Zatollah
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- 2019
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40. ABO blood group associated with cerebral venous thrombosis after Oxford-AstraZeneca COVID-19 vaccination: a case–control study.
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Ken-Dror, Gie, Sharma, Pankaj, van de Munckhof, Anita, Krzywicka, Katarzyna, van Kammen, Mayte Sánchez, Ghoreishi, Abdoreza, Borhani-Haghighi, Afshin, Negro, Alberto, Günther, Albrecht, Cervera, Alvaro, Tuladhar, Anil Man, Devroye, Annemie, Mengel, Annerose, Aujayeb, Avinash, Casolla, Barbara, Chew, Beng Lim Alvin, Zanferrari, Carla, Garcia-Esperon, Carlos, Wahl, Christoph M., and Alonso, Daniel Guisado
- Abstract
Objectives: To determine whether blood group influences development of cerebral venous thrombosis (CVT) after administration of the coronavirus disease 2019 (COVID-19) AstraZeneca ChAdOx1-S vaccine. Design: A case–control study. Univariate and multivariate logistic regression was used to determine the association between blood type and COVID-19 vaccination status. Setting: Vaccinated and unvaccinated patients recruited from the international Bio-Repository to Establish the Aetiology of Sinovenous Thrombosis study and the Cerebral Venous Sinus Thrombosis With Thrombocytopenia Syndrome Study Group. Participants: All patients were of European descent and age and sex matched. Cases (n = 82) were patients ≥18 years old who suffered a CVT within 28 days of a first dose of ChAdOx1-S vaccine. Controls (n = 441) were unvaccinated CVT patients ≥18 years old. All patients were of European descent. Main outcome measures: Frequency of blood type and ABO allele distribution by vaccination status. Results: Blood group O was found to be more prevalent among CVT patients with vaccine-induced thrombotic thrombocytopenia (VITT-CVT) after ChAdOx1-S vaccination compared with unvaccinated CVT cases (43% vs. 17%, respectively, p < 0.001). Blood group A was less prevalent, though still high, in the vaccinated group compared with the unvaccinated group (47% vs. 71%, respectively, p < 0.001). No significant differences were observed in the VITT-CVT non-ChAdOx1-S vaccine group and unvaccinated pre-COVID-19 CVT group for blood group. Conclusions: Blood group O is more prevalent among patients with VITT-CVT after ChAdOx1-S vaccination compared with unvaccinated cases, independent of well-established CVT risk factors. A larger dataset may be able to determine whether those of blood groups B and/or AB may be safely vaccinated with the low cost, readily available and easily transported ChAdOx1-S rather than adopting a complete ban. [ABSTRACT FROM AUTHOR]
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- 2024
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41. Cerebral venous thrombosis: a practical review.
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Borhani-Haghighi, Afshin and Hooshmandi, Etrat
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CEREBRAL embolism & thrombosis ,VENOUS thrombosis ,SARS-CoV-2 ,MELAS syndrome ,ORAL medication ,MAGNETIC resonance imaging ,SINUS thrombosis - Abstract
The evolution of the Coronavirus Disease-2019 pandemic and its vaccination raised more attention to cerebral venous thrombosis (CVT). Although CVT is less prevalent than arterial stroke, it results in larger years of life lost. CVT is more common in women and young patients. Predisposing factors are categorized as transient factors such as pregnancy, puerperium, oral contraceptive pills, trauma, and dehydration; and permanent factors such as neoplastic, vasculitic, thrombophilic, hematologic conditions, infectious causes such as severe acute respiratory syndrome coronavirus-2 infection and HIV. The most common manifestations are headache, seizures, focal neurologic deficits, altered level of consciousness, and cranial nerve palsies. The most common syndromes are stroke-like, raised-intracranial-pressure (ICP), isolated-headache, and encephalopathy, which may have overlaps. Diagnosis is mostly based on computed tomography, magnetic resonance imaging, and their respective venous sequences, supported by blood results abnormalities such as D-dimer elevation. Treatment includes the prevention of propagation of current thrombus with anticoagulation (heparin, or low molecular weight heparinoids and then warfarin, or direct oral anticoagulants), decreasing ICP (even by decompressive craniotomy), and treatment of specific underlying diseases. [ABSTRACT FROM AUTHOR]
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- 2024
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42. Sequential changes in expression of long non-coding RNAs THRIL and MALAT1 after ischemic stroke.
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Bayat, Mahnaz, Hooshmandi, Etrat, Karimi, Najmeh, Rahimi, Moosa, Tabrizi, Reza, Asadabadi, Tahereh, Salehi, Mohammad Saied, Zafarmand, Seyedeh Shaghayegh, Owjfard, Maryam, Garcia Esperon, Carlos, Spratt, Neil, Levi, Christopher, and Borhani-Haghighi, Afshin
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LINCRNA ,RNA ,TUMOR necrosis factors ,ISCHEMIC stroke ,RECEIVER operating characteristic curves - Abstract
Background: Inflammation is the major contributor to the pathophysiology of ischemic stroke (IS). Long non-coding ribonucleic acids (lncRNAs) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and tumor necrosis factor and heterogeneous nuclear ribonucleoprotein L-related immunoregulatory (THRIL) have been demonstrated to be up-regulated in inflammation and atherosclerosis. Therefore, we aimed to study the expression profile of these lncRNAs after IS. Methods: This observational case-control study was conducted in Namazi Hospital, Shiraz, Iran. The real-time polymerase chain reaction (RT-PCR) measured the sequential changes in circulating levels of MALAT1 and THRIL on days 1, 3, and 5 after IS. The receiver operating characteristic (ROC) curve analysis was used to estimate the diagnostic and prognostic potential of lncRNAs with the area under the curve (AUC). Results: In patients with IS, the relative MALAT1 and THRIL expressions were significantly higher than the controls (P < 0.001 and P < 0.01, respectively), on days 1, 3, and 5 after stroke. [ABSTRACT FROM AUTHOR]
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- 2024
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43. Sex differences in cerebral venous sinus thrombosis after adenoviral vaccination against COVID-19
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Scutelnic, Adrian, primary, van de Munckhof, Anita, additional, Krzywicka, Katarzyna, additional, van Kammen, Mayte Sánchez, additional, Lindgren, Erik, additional, Cordonnier, Charlotte, additional, Kleinig, Timothy J, additional, Field, Thalia S, additional, Poli, Sven, additional, Lemmens, Robin, additional, Middeldorp, Saskia, additional, Aaron, Sanjith, additional, Borhani-Haghighi, Afshin, additional, Arauz, Antonio, additional, Kremer Hovinga, Johanna A, additional, Günther, Albrecht, additional, Putaala, Jukka, additional, Wasay, Mohammad, additional, Conforto, Adriana Bastos, additional, de Sousa, Diana Aguiar, additional, Jood, Katarina, additional, Tatlisumak, Turgut, additional, Ferro, José M, additional, Coutinho, Jonathan M, additional, Arnold, Marcel, additional, Heldner, Mirjam R, additional, Antonenko, Kateryna, additional, Mbroh, Joshua, additional, Brodard, Justine, additional, Hooshmandi, Etrat, additional, Dizonno, Vanessa, additional, Devroye, Annemie, additional, Ciccone, Alfonso, additional, Wittstock, Matthias, additional, Zimmermann, Julian, additional, Bode, Felix J., additional, Skjelland, Mona, additional, Duan, Jiangang, additional, Hiltunen, Sini, additional, Zuurbier, Susanna M., additional, Petruzzellis, Marco, additional, Sharma, Aarti R., additional, Ghoreishi, Abdoreza, additional, Elkady, Ahmed, additional, Negro, Alberto, additional, Gutschalk, Alexander, additional, Schoenenberger, Silvia, additional, Nagel, Simon, additional, Buture, Alina, additional, Cervera, Alvaro, additional, Paiva Nunes, Ana, additional, Romina Montané Baños, Ana, additional, Tiede, Andreas, additional, Puthuppallil, Anemon, additional, Tuladhar, Anil M., additional, Mengel, Annerose, additional, Medina, Antonio, additional, Hellström Vogel, Åslög, additional, Tawa, Audrey, additional, Aujayeb, Avinash, additional, Ramasamy, Balakrishnan, additional, Casolla, Barbara, additional, Lim Alvin Chew, Beng, additional, Ziaadini, Bentalhoda, additional, Varkey Maramattom, Boby, additional, Buck, Brian, additional, Zanferrari, Carla, additional, Garcia-Esperon, Carlos, additional, Vayne, Caroline, additional, Legault, Catherine, additional, Jacobi, Christian, additional, Pfrepper, Christian, additional, Pelz, Johann, additional, Wahl, Christoph, additional, Kern, Rolf, additional, Tracol, Clement, additional, Soriano, Cristina, additional, Guisado-Alonso, Daniel, additional, Bougon, David, additional, Bal, Deepti, additional, Sergio Zimatore, Domenico, additional, Michalski, Dominik, additional, Blacquiere, Dylan, additional, Johansson, Elias, additional, Cuadrado-Godia, Elisa, additional, Sadeghi-Hokmabadi, Elyar, additional, Carrera, Emmanuel, additional, De Maistre, Emmanuel, additional, Saxhaug Kristoffersen, Espen, additional, Bonneville, Fabrice, additional, Geeraerts, Thomas, additional, Vuillier, Fabrice, additional, Giammello, Fabrizio, additional, D’Onofrio, Florindo, additional, Grillo, Francesco, additional, Caparros, François, additional, Susen, Sophie, additional, Maier, Frank, additional, Tsivgoulis, Georgios, additional, Gulli, Giosue, additional, Frisullo, Giovanni, additional, Franchineau, Guillaume, additional, Cangür, Hakan, additional, Katzberg, Hans, additional, Mozhdehipanah, Hossein, additional, Sibon, Igor, additional, Baharoglu, M. Irem, additional, Masjuan, Jaime, additional, Brar, Jaskiran, additional, Payen, Jean-Francois, additional, Burrow, Jim, additional, Fernandes, João, additional, Octavio López Esparza, Jorge, additional, Oen, Joyce, additional, Schouten, Judith, additional, Ng, Karl, additional, Chatterton, Sophie, additional, Wronski, Miriam, additional, Althaus, Katharina, additional, Garambois, Katia, additional, Derex, Laurent, additional, Puy, Laurent, additional, Poorsaadat, Leila, additional, Valler, Lenise, additional, Januzi de Almeida Rocha, Letícia, additional, Humbertjean, Lisa, additional, Lebrato Hernandez, Lucia, additional, Murillo-Bonilla, Luis, additional, Kellermair, Lukas, additional, Morin Martin, Mar, additional, Sofia Cotelli, Maria, additional, Hernandez Perez, Maria, additional, Zedde, Marialuisa, additional, Carvalho Dias, Mariana, additional, Dubois, Marie-Cecile, additional, Carvalho, Marta, additional, Ghiasian, Masoud, additional, Umaiorubahan, Meenakshisundaram, additional, Kumar Karunakaran, Ravi, additional, Roozbeh, Mehrdad, additional, Romoli, Michele, additional, Miranda, Miguel, additional, Saadatnia, Mohammad, additional, Bandettini di Poggio, Monica, additional, Scholz, Moritz J., additional, Kahnis, Robert, additional, Almasi-Dooghaee, Mostafa, additional, Hoseininejad Mir, Nahid, additional, Ichaporia, Nasli R., additional, Kumar Paramasivan, Naveen, additional, Erat Sreedharan, Sapna, additional, Sylaja, PN, additional, Raposo, Nicolas, additional, Fadakar, Nima, additional, Kruyt, Nyika, additional, Detante, Olivier, additional, Cuisenier, Pauline, additional, Huet, Olivier, additional, Sharma, Pankaj, additional, Candelaresi, Paolo, additional, Scoppettuolo, Pasquale, additional, Reiner, Peggy, additional, Nemati, Reza, additional, Vieira, Ricardo, additional, Goh, Rudy, additional, Murphy, Seán, additional, Timsit, Serge, additional, Coutts, Shelagh, additional, Sharma, Shyam S., additional, Bal, Simerpreet, additional, Kaul, Subhash, additional, Karapanayiotides, Theodoros, additional, Cox, Thomas, additional, Gattringer, Thomas, additional, Mathew, Thomas, additional, Bartsch, Thorsten, additional, Shaygannejad, Vahid, additional, Garcia-Talavera, Veronica, additional, Palma, Vincenzo, additional, Arslan, Yıldız, additional, Mirzaasgari, Zahra, additional, Yavari, Zeinab, additional, Zamani, Zohreh, additional, Bakchoul, Tamam, additional, Levi, Marcel, additional, and van Gorp, Eric C.M., additional
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- 2023
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44. Neurological Involvement in Malignant Atrophic Papulosis: A Comprehensive Review of Literature
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Yousefi, Samaneh, Borhani-Haghighi, Afshin, Safari, Anahid, and Shapiro, Lee
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Rare diseases -- Complications and side effects -- Development and progression ,Nervous system diseases -- Risk factors -- Development and progression ,Blood circulation disorders -- Complications and side effects -- Development and progression ,Health - Abstract
Byline: Samaneh. Yousefi, Afshin. Borhani-Haghighi, Anahid. Safari, Lee. Shapiro Malignant atrophic papulosis (MAP), or systemic Degos disease, is an obliterative vasculopathy of unknown origin, characterized by erythematous papules found on [...]
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- 2022
45. Gender-Specific Association of Leptin and Adiponectin Genes With Multiple Sclerosis
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Yousefian, Marziyeh, Nemati, Reza, Daryabor, Gholamreza, Gholijani, Naser, Nikseresht, Alireza, Borhani-Haghighi, Afshin, and Kamali-Sarvestani, Eskandar
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- 2018
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46. Cerebral venous sinus thrombosis due to vaccine-induced immune thrombotic thrombocytopenia in middle-income countries
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van de Munckhof, Anita, primary, Borhani-Haghighi, Afshin, additional, Aaron, Sanjith, additional, Krzywicka, Katarzyna, additional, van Kammen, Mayte Sánchez, additional, Cordonnier, Charlotte, additional, Kleinig, Timothy J, additional, Field, Thalia S, additional, Poli, Sven, additional, Lemmens, Robin, additional, Scutelnic, Adrian, additional, Lindgren, Erik, additional, Duan, Jiangang, additional, Arslan, Yıldız, additional, van Gorp, Eric CM, additional, Kremer Hovinga, Johanna A, additional, Günther, Albrecht, additional, Jood, Katarina, additional, Tatlisumak, Turgut, additional, Putaala, Jukka, additional, Heldner, Mirjam R, additional, Arnold, Marcel, additional, de Sousa, Diana Aguiar, additional, Wasay, Mohammad, additional, Arauz, Antonio, additional, Conforto, Adriana Bastos, additional, Ferro, José M, additional, Coutinho, Jonathan M, additional, Mbroh, Joshua, additional, Ciccone, Alfonso, additional, Wittstock, Matthias, additional, Zimmermann, Julian, additional, Bode, Felix J, additional, Skjelland, Mona, additional, Dizonno, Vanessa, additional, Devroye, Annemie, additional, Hiltunen, Sini, additional, Petruzzellis, Marco, additional, Bakchoul, Tamam, additional, Levi, Marcel, additional, Middeldorp, Saskia, additional, Sharma, Aarti R, additional, Ghoreishi, Abdoreza, additional, Elkady, Ahmed, additional, Negro, Alberto, additional, Gutschalk, Alexander, additional, Buture, Alina, additional, Cervera, Alvaro, additional, Paiva Nunes, Ana, additional, Romina Montané Baños, Ana, additional, Tiede, Andreas, additional, Tuladhar, Anil M, additional, Mengel, Annerose, additional, Medina, Antonio, additional, Aujayeb, Avinash, additional, Ramasamy, Balakrishnan, additional, Casolla, Barbara, additional, Spratt, Neil, additional, Ziaadini, Bentolhoda, additional, Varkey Maramattom, Boby, additional, Buck, Brian, additional, Garcia-Esperon, Carlos, additional, Vayne, Caroline, additional, Jacobi, Christian, additional, Pfrepper, Christian, additional, Bal, Deepti, additional, Sergio Zimatore, Domenico, additional, Michalski, Dominik, additional, Blacquiere, Dylan, additional, Johansson, Elias, additional, Cuadrado-Godia, Elisa, additional, Sadeghi-Hokmabadi, Elyar, additional, Carrera, Emmanuel, additional, Maistre, Emmanuel De, additional, Saxhaug Kristoffersen, Espen, additional, Hooshmandi, Etrat, additional, Bonneville, Fabrice, additional, Vuillier, Fabrice, additional, Giammello, Fabrizio, additional, D’Onofrio, Florindo, additional, Tsivgoulis, Georgios, additional, Gulli, Giosue, additional, Katzberg, Hans, additional, Sibon, Igor, additional, Baharoglu, Irem, additional, Masjuan, Jaime, additional, Fernandes, João, additional, Pelz, Johann, additional, Octavio López Esparza, Jorge, additional, Schouten, Judith, additional, Ng, Karl, additional, Derex, Laurent, additional, Puy, Laurent, additional, Poorsaadat, Leila, additional, Valler, Lenise, additional, Januzi de Almeida Rocha, Letícia, additional, Murillo-Bonilla, Luis, additional, Kellermair, Lukas, additional, Morin Martin, Mar, additional, Sofia Cotelli, Maria, additional, Hernandez Perez, Maria, additional, Zedde, Marialuisa, additional, Carvalho Dias, Mariana, additional, Carvalho, Marta, additional, Ghiasian, Masoud, additional, Umaiorubahan, Meenakshisundaram, additional, Roozbeh, Mehrdad, additional, Romoli, Michele, additional, Miranda, Miguel, additional, Wronski, Miriam, additional, Saadatnia, Mohammad, additional, Bandettini di Poggio, Monica, additional, Almasi-Dooghaee, Mostafa, additional, Hoseininejad Mir, Nahid, additional, Ichaporia, Nasli R, additional, Kumar Paramasivan, Naveen, additional, Raposo, Nicolas, additional, Fadakar, Nima, additional, Kruyt, Nyika, additional, Detante, Olivier, additional, Sharma, Pankaj, additional, Candelaresi, Paolo, additional, Scoppettuolo, Pasquale, additional, Reiner, Peggy, additional, Sylaja, PN, additional, Kumar Karunakaran, Ravi, additional, Vieira, Ricardo, additional, Kern, Rolf, additional, Goh, Rudy, additional, Erat Sreedharan, Sapna, additional, Murphy, Seán, additional, Timsit, Serge, additional, Coutts, Shelagh, additional, Sharma, Shyam S, additional, Schoenenberger, Silvia, additional, Nagel, Simon, additional, Kaul, Subhash, additional, Karapanayiotides, Theodoros, additional, Gattringer, Thomas, additional, Mathew, Thomas, additional, Bartsch, Thorsten, additional, Palma, Vincenzo, additional, Mirzaasgari, Zahra, additional, Zamani, Zohreh, additional, Mirahmadizadeh, Alireza, additional, Gutierrez-Romero, Alonso, additional, Iván Valdes-Ferrer, Ivan, additional, Elizabeth Ceballos-Liceaga, Santa, additional, and Maria Santibañez-Copado, Ana, additional
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- 2023
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47. Mechanism of action and therapeutic potential of dimethyl fumarate in ischemic stroke
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Owjfard, Maryam, primary, Karimi, Farzaneh, additional, Mallahzadeh, Arashk, additional, Nabavizadeh, Seyed Ali, additional, Namavar, Mohammad Reza, additional, Saadi, Mahdiyar Iravani, additional, Hooshmandi, Etrat, additional, Salehi, Mohammad Saied, additional, Zafarmand, Seyedeh Shaghayegh, additional, Bayat, Mahnaz, additional, Karimlou, Sedigheh, additional, and Borhani‐Haghighi, Afshin, additional
- Published
- 2023
- Full Text
- View/download PDF
48. Sex differences in cerebral venous sinus thrombosis after adenoviral vaccination against COVID-19
- Author
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Scutelnic, Adrian, van de Munckhof, Anita, Krzywicka, Katarzyna, van Kammen, Mayte Sánchez, Lindgren, Erik, Cordonnier, Charlotte, Kleinig, Timothy J., Field, Thalia S., Poli, Sven, Lemmens, Robin, Middeldorp, Saskia, Aaron, Sanjith, Borhani-Haghighi, Afshin, Arauz, Antonio, Kremer Hovinga, Johanna A., Günther, Albrecht, Putaala, Jukka, Wasay, Mohammad, Conforto, Adriana Bastos, de Sousa, Diana Aguiar, Jood, Katarina, Tatlisumak, Turgut, Ferro, José M., Coutinho, Jonathan M., Arnold, Marcel, Heldner, Mirjam R., Antonenko, Kateryna, Mbroh, Joshua, Brodard, Justine, Hooshmandi, Etrat, Dizonno, Vanessa, Devroye, Annemie, Ciccone, Alfonso, Wittstock, Matthias, Zimmermann, Julian, Bode, Felix J., Skjelland, Mona, Duan, Jiangang, Hiltunen, Sini, Zuurbier, Susanna M., Petruzzellis, Marco, Sharma, Aarti R., Ghoreishi, Abdoreza, Elkady, Ahmed, Negro, Alberto, Gutschalk, Alexander, Schoenenberger, Silvia, Nagel, Simon, Buture, Alina, Cervera, Alvaro, Paiva Nunes, Ana, Romina Montané Baños, Ana, Tiede, Andreas, Puthuppallil, Anemon, Tuladhar, Anil M., Mengel, Annerose, Medina, Antonio, Hellström Vogel, Åslög, Tawa, Audrey, Aujayeb, Avinash, Ramasamy, Balakrishnan, Casolla, Barbara, Lim Alvin Chew, Beng, Ziaadini, Bentalhoda, Varkey Maramattom, Boby, Buck, Brian, Zanferrari, Carla, Garcia-Esperon, Carlos, Vayne, Caroline, Legault, Catherine, Jacobi, Christian, Pfrepper, Christian, Pelz, Johann, Wahl, Christoph, Kern, Rolf, Tracol, Clement, Soriano, Cristina, Guisado-Alonso, Daniel, Bougon, David, Bal, Deepti, Sergio Zimatore, Domenico, Michalski, Dominik, Blacquiere, Dylan, Johansson, Elias, Cuadrado-Godia, Elisa, Sadeghi-Hokmabadi, Elyar, Carrera, Emmanuel, De Maistre, Emmanuel, Saxhaug Kristoffersen, Espen, Bonneville, Fabrice, Geeraerts, Thomas, Vuillier, Fabrice, Giammello, Fabrizio, D’Onofrio, Florindo, Grillo, Francesco, Caparros, François, Susen, Sophie, Maier, Frank, Tsivgoulis, Georgios, Gulli, Giosue, Frisullo, Giovanni, Franchineau, Guillaume, Cangür, Hakan, Katzberg, Hans, Mozhdehipanah, Hossein, Sibon, Igor, Baharoglu, M. Irem, Masjuan, Jaime, Brar, Jaskiran, Payen, Jean Francois, Burrow, Jim, Fernandes, João, Octavio López Esparza, Jorge, Oen, Joyce, Schouten, Judith, Ng, Karl, Chatterton, Sophie, Wronski, Miriam, Althaus, Katharina, Garambois, Katia, Derex, Laurent, Puy, Laurent, Poorsaadat, Leila, Valler, Lenise, Januzi de Almeida Rocha, Letícia, Humbertjean, Lisa, Lebrato Hernandez, Lucia, Murillo-Bonilla, Luis, Kellermair, Lukas, Morin Martin, Mar, Sofia Cotelli, Maria, Hernandez Perez, Maria, Zedde, Marialuisa, Carvalho Dias, Mariana, Dubois, Marie Cecile, Carvalho, Marta, Ghiasian, Masoud, Umaiorubahan, Meenakshisundaram, Kumar Karunakaran, Ravi, Roozbeh, Mehrdad, Romoli, Michele, Miranda, Miguel, Saadatnia, Mohammad, Bandettini di Poggio, Monica, Scholz, Moritz J., Kahnis, Robert, Almasi-Dooghaee, Mostafa, Hoseininejad Mir, Nahid, Ichaporia, Nasli R., Kumar Paramasivan, Naveen, Erat Sreedharan, Sapna, Sylaja, P. N., Raposo, Nicolas, Fadakar, Nima, Kruyt, Nyika, Detante, Olivier, Cuisenier, Pauline, Huet, Olivier, Sharma, Pankaj, Candelaresi, Paolo, Scoppettuolo, Pasquale, Reiner, Peggy, Nemati, Reza, Vieira, Ricardo, Goh, Rudy, Murphy, Seán, Timsit, Serge, Coutts, Shelagh, Sharma, Shyam S., Bal, Simerpreet, Kaul, Subhash, Karapanayiotides, Theodoros, Cox, Thomas, Gattringer, Thomas, Mathew, Thomas, Bartsch, Thorsten, Shaygannejad, Vahid, Garcia-Talavera, Veronica, Palma, Vincenzo, Arslan, Yıldız, Mirzaasgari, Zahra, Yavari, Zeinab, Zamani, Zohreh, Bakchoul, Tamam, Levi, Marcel, van Gorp, Eric C.M., Scutelnic, Adrian, van de Munckhof, Anita, Krzywicka, Katarzyna, van Kammen, Mayte Sánchez, Lindgren, Erik, Cordonnier, Charlotte, Kleinig, Timothy J., Field, Thalia S., Poli, Sven, Lemmens, Robin, Middeldorp, Saskia, Aaron, Sanjith, Borhani-Haghighi, Afshin, Arauz, Antonio, Kremer Hovinga, Johanna A., Günther, Albrecht, Putaala, Jukka, Wasay, Mohammad, Conforto, Adriana Bastos, de Sousa, Diana Aguiar, Jood, Katarina, Tatlisumak, Turgut, Ferro, José M., Coutinho, Jonathan M., Arnold, Marcel, Heldner, Mirjam R., Antonenko, Kateryna, Mbroh, Joshua, Brodard, Justine, Hooshmandi, Etrat, Dizonno, Vanessa, Devroye, Annemie, Ciccone, Alfonso, Wittstock, Matthias, Zimmermann, Julian, Bode, Felix J., Skjelland, Mona, Duan, Jiangang, Hiltunen, Sini, Zuurbier, Susanna M., Petruzzellis, Marco, Sharma, Aarti R., Ghoreishi, Abdoreza, Elkady, Ahmed, Negro, Alberto, Gutschalk, Alexander, Schoenenberger, Silvia, Nagel, Simon, Buture, Alina, Cervera, Alvaro, Paiva Nunes, Ana, Romina Montané Baños, Ana, Tiede, Andreas, Puthuppallil, Anemon, Tuladhar, Anil M., Mengel, Annerose, Medina, Antonio, Hellström Vogel, Åslög, Tawa, Audrey, Aujayeb, Avinash, Ramasamy, Balakrishnan, Casolla, Barbara, Lim Alvin Chew, Beng, Ziaadini, Bentalhoda, Varkey Maramattom, Boby, Buck, Brian, Zanferrari, Carla, Garcia-Esperon, Carlos, Vayne, Caroline, Legault, Catherine, Jacobi, Christian, Pfrepper, Christian, Pelz, Johann, Wahl, Christoph, Kern, Rolf, Tracol, Clement, Soriano, Cristina, Guisado-Alonso, Daniel, Bougon, David, Bal, Deepti, Sergio Zimatore, Domenico, Michalski, Dominik, Blacquiere, Dylan, Johansson, Elias, Cuadrado-Godia, Elisa, Sadeghi-Hokmabadi, Elyar, Carrera, Emmanuel, De Maistre, Emmanuel, Saxhaug Kristoffersen, Espen, Bonneville, Fabrice, Geeraerts, Thomas, Vuillier, Fabrice, Giammello, Fabrizio, D’Onofrio, Florindo, Grillo, Francesco, Caparros, François, Susen, Sophie, Maier, Frank, Tsivgoulis, Georgios, Gulli, Giosue, Frisullo, Giovanni, Franchineau, Guillaume, Cangür, Hakan, Katzberg, Hans, Mozhdehipanah, Hossein, Sibon, Igor, Baharoglu, M. Irem, Masjuan, Jaime, Brar, Jaskiran, Payen, Jean Francois, Burrow, Jim, Fernandes, João, Octavio López Esparza, Jorge, Oen, Joyce, Schouten, Judith, Ng, Karl, Chatterton, Sophie, Wronski, Miriam, Althaus, Katharina, Garambois, Katia, Derex, Laurent, Puy, Laurent, Poorsaadat, Leila, Valler, Lenise, Januzi de Almeida Rocha, Letícia, Humbertjean, Lisa, Lebrato Hernandez, Lucia, Murillo-Bonilla, Luis, Kellermair, Lukas, Morin Martin, Mar, Sofia Cotelli, Maria, Hernandez Perez, Maria, Zedde, Marialuisa, Carvalho Dias, Mariana, Dubois, Marie Cecile, Carvalho, Marta, Ghiasian, Masoud, Umaiorubahan, Meenakshisundaram, Kumar Karunakaran, Ravi, Roozbeh, Mehrdad, Romoli, Michele, Miranda, Miguel, Saadatnia, Mohammad, Bandettini di Poggio, Monica, Scholz, Moritz J., Kahnis, Robert, Almasi-Dooghaee, Mostafa, Hoseininejad Mir, Nahid, Ichaporia, Nasli R., Kumar Paramasivan, Naveen, Erat Sreedharan, Sapna, Sylaja, P. N., Raposo, Nicolas, Fadakar, Nima, Kruyt, Nyika, Detante, Olivier, Cuisenier, Pauline, Huet, Olivier, Sharma, Pankaj, Candelaresi, Paolo, Scoppettuolo, Pasquale, Reiner, Peggy, Nemati, Reza, Vieira, Ricardo, Goh, Rudy, Murphy, Seán, Timsit, Serge, Coutts, Shelagh, Sharma, Shyam S., Bal, Simerpreet, Kaul, Subhash, Karapanayiotides, Theodoros, Cox, Thomas, Gattringer, Thomas, Mathew, Thomas, Bartsch, Thorsten, Shaygannejad, Vahid, Garcia-Talavera, Veronica, Palma, Vincenzo, Arslan, Yıldız, Mirzaasgari, Zahra, Yavari, Zeinab, Zamani, Zohreh, Bakchoul, Tamam, Levi, Marcel, and van Gorp, Eric C.M.
- Abstract
Introduction: Cerebral venous sinus thrombosis associated with vaccine-induced immune thrombotic thrombocytopenia (CVST-VITT) is a severe disease with high mortality. There are few data on sex differences in CVST-VITT. The aim of our study was to investigate the differences in presentation, treatment, clinical course, complications, and outcome of CVST-VITT between women and men. Patients and methods: We used data from an ongoing international registry on CVST-VITT. VITT was diagnosed according to the Pavord criteria. We compared the characteristics of CVST-VITT in women and men. Results: Of 133 patients with possible, probable, or definite CVST-VITT, 102 (77%) were women. Women were slightly younger [median age 42 (IQR 28–54) vs 45 (28–56)], presented more often with coma (26% vs 10%) and had a lower platelet count at presentation [median (IQR) 50x109/L (28–79) vs 68 (30–125)] than men. The nadir platelet count was lower in women [median (IQR) 34 (19–62) vs 53 (20–92)]. More women received endovascular treatment than men (15% vs 6%). Rates of treatment with intravenous immunoglobulins were similar (63% vs 66%), as were new venous thromboembolic events (14% vs 14%) and major bleeding complications (30% vs 20%). Rates of good functional outcome (modified Rankin Scale 0-2, 42% vs 45%) and in-hospital death (39% vs 41%) did not differ. Discussion and conclusions: Three quarters of CVST-VITT patients in this study were women. Women were more severely affected at presentation, but clinical course and outcome did not differ between women and men. VITT-specific treatments were overall similar, but more women received endovascular treatment.
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- 2023
49. Cerebral venous sinus thrombosis due to vaccine-induced immune thrombotic thrombocytopenia in middle-income countries
- Author
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van de Munckhof, Anita, Borhani-Haghighi, Afshin, Aaron, Sanjith, Krzywicka, Katarzyna, van Kammen, Mayte Sánchez, Cordonnier, Charlotte, Kleinig, Timothy J., Field, Thalia S., Poli, Sven, Lemmens, Robin, Scutelnic, Adrian, Lindgren, Erik, Duan, Jiangang, Arslan, Yıldız, van Gorp, Eric C.M., Kremer Hovinga, Johanna A., Günther, Albrecht, Jood, Katarina, Tatlisumak, Turgut, Putaala, Jukka, Heldner, Mirjam R., Arnold, Marcel, de Sousa, Diana Aguiar, Wasay, Mohammad, Arauz, Antonio, Conforto, Adriana Bastos, Ferro, José M., Coutinho, Jonathan M., Mbroh, Joshua, Ciccone, Alfonso, Wittstock, Matthias, Zimmermann, Julian, Bode, Felix J., Skjelland, Mona, Dizonno, Vanessa, Devroye, Annemie, Hiltunen, Sini, Petruzzellis, Marco, Bakchoul, Tamam, Levi, Marcel, Middeldorp, Saskia, Sharma, Aarti R., Ghoreishi, Abdoreza, Elkady, Ahmed, Negro, Alberto, Gutschalk, Alexander, Buture, Alina, Cervera, Alvaro, Paiva Nunes, Ana, Romina Montané Baños, Ana, Tiede, Andreas, Tuladhar, Anil M., Mengel, Annerose, Medina, Antonio, Aujayeb, Avinash, Ramasamy, Balakrishnan, Casolla, Barbara, Spratt, Neil, Ziaadini, Bentolhoda, Varkey Maramattom, Boby, Buck, Brian, Garcia-Esperon, Carlos, Vayne, Caroline, Jacobi, Christian, Pfrepper, Christian, Bal, Deepti, Sergio Zimatore, Domenico, Michalski, Dominik, Blacquiere, Dylan, Johansson, Elias, Cuadrado-Godia, Elisa, Sadeghi-Hokmabadi, Elyar, Carrera, Emmanuel, Maistre, Emmanuel De, Saxhaug Kristoffersen, Espen, Hooshmandi, Etrat, Bonneville, Fabrice, Vuillier, Fabrice, Giammello, Fabrizio, D’Onofrio, Florindo, Tsivgoulis, Georgios, Gulli, Giosue, Katzberg, Hans, Sibon, Igor, Baharoglu, Irem, Masjuan, Jaime, Fernandes, João, Pelz, Johann, Octavio López Esparza, Jorge, Schouten, Judith, Ng, Karl, Derex, Laurent, Puy, Laurent, Poorsaadat, Leila, Valler, Lenise, Januzi de Almeida Rocha, Letícia, Murillo-Bonilla, Luis, Kellermair, Lukas, Morin Martin, Mar, Sofia Cotelli, Maria, Hernandez Perez, Maria, Zedde, Marialuisa, Carvalho Dias, Mariana, Carvalho, Marta, Ghiasian, Masoud, Umaiorubahan, Meenakshisundaram, Roozbeh, Mehrdad, Romoli, Michele, Miranda, Miguel, Wronski, Miriam, Saadatnia, Mohammad, Bandettini di Poggio, Monica, Almasi-Dooghaee, Mostafa, Hoseininejad Mir, Nahid, Ichaporia, Nasli R., Kumar Paramasivan, Naveen, Raposo, Nicolas, Fadakar, Nima, Kruyt, Nyika, Detante, Olivier, Sharma, Pankaj, Candelaresi, Paolo, Scoppettuolo, Pasquale, Reiner, Peggy, Sylaja, P. N., Kumar Karunakaran, Ravi, Vieira, Ricardo, Kern, Rolf, Goh, Rudy, Erat Sreedharan, Sapna, Murphy, Seán, Timsit, Serge, Coutts, Shelagh, Sharma, Shyam S., Schoenenberger, Silvia, Nagel, Simon, Kaul, Subhash, Karapanayiotides, Theodoros, Gattringer, Thomas, Mathew, Thomas, Bartsch, Thorsten, Palma, Vincenzo, Mirzaasgari, Zahra, Zamani, Zohreh, Mirahmadizadeh, Alireza, Gutierrez-Romero, Alonso, Iván Valdes-Ferrer, Ivan, Elizabeth Ceballos-Liceaga, Santa, Maria Santibañez-Copado, Ana, van de Munckhof, Anita, Borhani-Haghighi, Afshin, Aaron, Sanjith, Krzywicka, Katarzyna, van Kammen, Mayte Sánchez, Cordonnier, Charlotte, Kleinig, Timothy J., Field, Thalia S., Poli, Sven, Lemmens, Robin, Scutelnic, Adrian, Lindgren, Erik, Duan, Jiangang, Arslan, Yıldız, van Gorp, Eric C.M., Kremer Hovinga, Johanna A., Günther, Albrecht, Jood, Katarina, Tatlisumak, Turgut, Putaala, Jukka, Heldner, Mirjam R., Arnold, Marcel, de Sousa, Diana Aguiar, Wasay, Mohammad, Arauz, Antonio, Conforto, Adriana Bastos, Ferro, José M., Coutinho, Jonathan M., Mbroh, Joshua, Ciccone, Alfonso, Wittstock, Matthias, Zimmermann, Julian, Bode, Felix J., Skjelland, Mona, Dizonno, Vanessa, Devroye, Annemie, Hiltunen, Sini, Petruzzellis, Marco, Bakchoul, Tamam, Levi, Marcel, Middeldorp, Saskia, Sharma, Aarti R., Ghoreishi, Abdoreza, Elkady, Ahmed, Negro, Alberto, Gutschalk, Alexander, Buture, Alina, Cervera, Alvaro, Paiva Nunes, Ana, Romina Montané Baños, Ana, Tiede, Andreas, Tuladhar, Anil M., Mengel, Annerose, Medina, Antonio, Aujayeb, Avinash, Ramasamy, Balakrishnan, Casolla, Barbara, Spratt, Neil, Ziaadini, Bentolhoda, Varkey Maramattom, Boby, Buck, Brian, Garcia-Esperon, Carlos, Vayne, Caroline, Jacobi, Christian, Pfrepper, Christian, Bal, Deepti, Sergio Zimatore, Domenico, Michalski, Dominik, Blacquiere, Dylan, Johansson, Elias, Cuadrado-Godia, Elisa, Sadeghi-Hokmabadi, Elyar, Carrera, Emmanuel, Maistre, Emmanuel De, Saxhaug Kristoffersen, Espen, Hooshmandi, Etrat, Bonneville, Fabrice, Vuillier, Fabrice, Giammello, Fabrizio, D’Onofrio, Florindo, Tsivgoulis, Georgios, Gulli, Giosue, Katzberg, Hans, Sibon, Igor, Baharoglu, Irem, Masjuan, Jaime, Fernandes, João, Pelz, Johann, Octavio López Esparza, Jorge, Schouten, Judith, Ng, Karl, Derex, Laurent, Puy, Laurent, Poorsaadat, Leila, Valler, Lenise, Januzi de Almeida Rocha, Letícia, Murillo-Bonilla, Luis, Kellermair, Lukas, Morin Martin, Mar, Sofia Cotelli, Maria, Hernandez Perez, Maria, Zedde, Marialuisa, Carvalho Dias, Mariana, Carvalho, Marta, Ghiasian, Masoud, Umaiorubahan, Meenakshisundaram, Roozbeh, Mehrdad, Romoli, Michele, Miranda, Miguel, Wronski, Miriam, Saadatnia, Mohammad, Bandettini di Poggio, Monica, Almasi-Dooghaee, Mostafa, Hoseininejad Mir, Nahid, Ichaporia, Nasli R., Kumar Paramasivan, Naveen, Raposo, Nicolas, Fadakar, Nima, Kruyt, Nyika, Detante, Olivier, Sharma, Pankaj, Candelaresi, Paolo, Scoppettuolo, Pasquale, Reiner, Peggy, Sylaja, P. N., Kumar Karunakaran, Ravi, Vieira, Ricardo, Kern, Rolf, Goh, Rudy, Erat Sreedharan, Sapna, Murphy, Seán, Timsit, Serge, Coutts, Shelagh, Sharma, Shyam S., Schoenenberger, Silvia, Nagel, Simon, Kaul, Subhash, Karapanayiotides, Theodoros, Gattringer, Thomas, Mathew, Thomas, Bartsch, Thorsten, Palma, Vincenzo, Mirzaasgari, Zahra, Zamani, Zohreh, Mirahmadizadeh, Alireza, Gutierrez-Romero, Alonso, Iván Valdes-Ferrer, Ivan, Elizabeth Ceballos-Liceaga, Santa, and Maria Santibañez-Copado, Ana
- Abstract
Background: Adenovirus-based COVID-19 vaccines are extensively used in low- and middle-income countries (LMICs). Remarkably, cases of cerebral venous sinus thrombosis due to vaccine-induced immune thrombotic thrombocytopenia (CVST-VITT) have rarely been reported from LMICs. Aims: We studied the frequency, manifestations, treatment, and outcomes of CVST-VITT in LMICs. Methods: We report data from an international registry on CVST after COVID-19 vaccination. VITT was classified according to the Pavord criteria. We compared CVST-VITT cases from LMICs to cases from high-income countries (HICs). Results: Until August 2022, 228 CVST cases were reported, of which 63 were from LMICs (all middle-income countries [MICs]: Brazil, China, India, Iran, Mexico, Pakistan, Turkey). Of these 63, 32 (51%) met the VITT criteria, compared to 103 of 165 (62%) from HICs. Only 5 of the 32 (16%) CVST-VITT cases from MICs had definite VITT, mostly because anti-platelet factor 4 antibodies were often not tested. The median age was 26 (interquartile range [IQR] 20–37) versus 47 (IQR 32–58) years, and the proportion of women was 25 of 32 (78%) versus 77 of 103 (75%) in MICs versus HICs, respectively. Patients from MICs were diagnosed later than patients from HICs (1/32 [3%] vs. 65/103 [63%] diagnosed before May 2021). Clinical manifestations, including intracranial hemorrhage, were largely similar as was intravenous immunoglobulin use. In-hospital mortality was lower in MICs (7/31 [23%, 95% confidence interval (CI) 11–40]) than in HICs (44/102 [43%, 95% CI 34–53], p = 0.039). Conclusions: The number of CVST-VITT cases reported from LMICs was small despite the widespread use of adenoviral vaccines. Clinical manifestations and treatment of CVST-VITT cases were largely similar in MICs and HICs, while mortality was lower in patients from MICs.
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- 2023
50. Decompressive surgery in cerebral venous sinus thrombosis due to vaccine-induced immune thrombotic thrombocytopenia
- Author
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Krzywicka, Katarzyna, Aguiar de Sousa, Diana, Cordonnier, Charlotte, Bode, Felix J., Field, Thalia S., Michalski, Dominik, Pelz, Johann, Skjelland, Mona, Wiedmann, Markus, Zimmermann, Julian, Wittstock, Matthias, Zanotti, Bruno, Ciccone, Alfonso, Bandettini di Poggio, Monica, Borhani-Haghighi, Afshin, Chatterton, Sophie, Aujayeb, Avinash, Devroye, Annemie, Dizonno, Vanessa, Geeraerts, Thomas, Giammello, Fabrizio, Günther, Albrecht, Ichaporia, Nasli R., Kleinig, Timothy, Kristoffersen, Espen S., Lemmens, Robin, De Maistre, Emmanuel, Mirzaasgari, Zahra, Payen, Jean Francois, Putaala, Jukka, Petruzzellis, Marco, Raposo, Nicolas, Sadeghi-Hokmabadi, Elyar, Schoenenberger, Silvia, Umaiorubahan, Meenakshisundaram, Sylaja, Padmavathy N., van de Munckhof, Anita, Sánchez van Kammen, Mayte, Lindgren, Erik, Jood, Katarina, Scutelnic, Adrian, Heldner, Mirjam R., Poli, Sven, Kruip, Marieke J.H.A., Arauz, Antonio, Conforto, Adriana B., Aaron, Sanjith, Middeldorp, Saskia, Tatlisumak, Turgut, Arnold, Marcel, Krzywicka, Katarzyna, Aguiar de Sousa, Diana, Cordonnier, Charlotte, Bode, Felix J., Field, Thalia S., Michalski, Dominik, Pelz, Johann, Skjelland, Mona, Wiedmann, Markus, Zimmermann, Julian, Wittstock, Matthias, Zanotti, Bruno, Ciccone, Alfonso, Bandettini di Poggio, Monica, Borhani-Haghighi, Afshin, Chatterton, Sophie, Aujayeb, Avinash, Devroye, Annemie, Dizonno, Vanessa, Geeraerts, Thomas, Giammello, Fabrizio, Günther, Albrecht, Ichaporia, Nasli R., Kleinig, Timothy, Kristoffersen, Espen S., Lemmens, Robin, De Maistre, Emmanuel, Mirzaasgari, Zahra, Payen, Jean Francois, Putaala, Jukka, Petruzzellis, Marco, Raposo, Nicolas, Sadeghi-Hokmabadi, Elyar, Schoenenberger, Silvia, Umaiorubahan, Meenakshisundaram, Sylaja, Padmavathy N., van de Munckhof, Anita, Sánchez van Kammen, Mayte, Lindgren, Erik, Jood, Katarina, Scutelnic, Adrian, Heldner, Mirjam R., Poli, Sven, Kruip, Marieke J.H.A., Arauz, Antonio, Conforto, Adriana B., Aaron, Sanjith, Middeldorp, Saskia, Tatlisumak, Turgut, and Arnold, Marcel
- Abstract
Background and purpose: Cerebral venous sinus thrombosis due to vaccine-induced immune thrombotic thrombocytopenia (CVST-VITT) is an adverse drug reaction occurring after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. CVST-VITT patients often present with large intracerebral haemorrhages and a high proportion undergoes decompressive surgery. Clinical characteristics, therapeutic management and outcomes of CVST-VITT patients who underwent decompressive surgery are described and predictors of in-hospital mortality in these patients are explored. Methods: Data from an ongoing international registry of patients who developed CVST within 28 days of SARS-CoV-2 vaccination, reported between 29 March 2021 and 10 May 2022, were used. Definite, probable and possible VITT cases, as defined by Pavord et al. (N Engl J Med 2021; 385: 1680–1689), were included. Results: Decompressive surgery was performed in 34/128 (27%) patients with CVST-VITT. In-hospital mortality was 22/34 (65%) in the surgical and 27/94 (29%) in the non-surgical group (p < 0.001). In all surgical cases, the cause of death was brain herniation. The highest mortality rates were found amongst patients with preoperative coma (17/18, 94% vs. 4/14, 29% in the non-comatose; p < 0.001) and bilaterally absent pupillary reflexes (7/7, 100% vs. 6/9, 67% with unilaterally reactive pupil, and 4/11, 36% with bilaterally reactive pupils; p = 0.023). Postoperative imaging revealed worsening of index haemorrhagic lesion in 19 (70%) patients and new haemorrhagic lesions in 16 (59%) patients. At a median follow-up of 6 months, 8/10 of surgical CVST-VITT who survived admission were functionally independent. Conclusions: Almost two-thirds of surgical CVST-VITT patients died during hospital admission. Preoperative coma and bilateral absence of pupillary responses were associated with higher mortality rates. Survivors often achieved functional independence.
- Published
- 2023
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