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Sex differences in cerebral venous sinus thrombosis after adenoviral vaccination against COVID-19
- Source :
- Scutelnic , A , van de Munckhof , A , Krzywicka , K , van Kammen , M S , Lindgren , E , Cordonnier , C , Kleinig , T J , Field , T S , Poli , S , Lemmens , R , Middeldorp , S , Aaron , S , Borhani-Haghighi , A , Arauz , A , Kremer Hovinga , J A , Günther , A , Putaala , J , Wasay , M , Conforto , A B , de Sousa , D A , Jood , K , Tatlisumak , T , Ferro , J M , Coutinho , J M , Arnold , M , Heldner , M R , Antonenko , K , Mbroh , J , Brodard , J , Hooshmandi , E , Dizonno , V , Devroye , A , Ciccone , A , Wittstock , M , Zimmermann , J , Bode , F J , Skjelland , M , Duan , J , Hiltunen , S , Zuurbier , S M , Petruzzellis , M , Sharma , A R , Ghoreishi , A , Elkady , A , Negro , A , Gutschalk , A , Schoenenberger , S , Nagel , S , Buture , A , Cervera , A , Paiva Nunes , A , Romina Montané Baños , A , Tiede , A , Puthuppallil , A , Tuladhar , A M , Mengel , A , Medina , A , Hellström Vogel , Å , Tawa , A , Aujayeb , A , Ramasamy , B , Casolla , B , Lim Alvin Chew , B , Ziaadini , B , Varkey Maramattom , B , Buck , B , Zanferrari , C , Garcia-Esperon , C , Vayne , C , Legault , C , Jacobi , C , Pfrepper , C , Pelz , J , Wahl , C , Kern , R , Tracol , C , Soriano , C , Guisado-Alonso , D , Bougon , D , Bal , D , Sergio Zimatore , D , Michalski , D , Blacquiere , D , Johansson , E , Cuadrado-Godia , E , Sadeghi-Hokmabadi , E , Carrera , E , De Maistre , E , Saxhaug Kristoffersen , E , Bonneville , F , Geeraerts , T , Vuillier , F , Giammello , F , D’Onofrio , F , Grillo , F , Caparros , F , Susen , S , Maier , F , Tsivgoulis , G , Gulli , G , Frisullo , G , Franchineau , G , Cangür , H , Katzberg , H , Mozhdehipanah , H , Sibon , I , Baharoglu , M I , Masjuan , J , Brar , J , Payen , J F , Burrow , J , Fernandes , J , Octavio López Esparza , J , Oen , J , Schouten , J , Ng , K , Chatterton , S , Wronski , M , Althaus , K , Garambois , K , Derex , L , Puy , L , Poorsaadat , L , Valler , L , Januzi de Almeida Rocha , L , Humbertjean , L , Lebrato Hernandez , L , Murillo-Bo
- Publication Year :
- 2023
-
Abstract
- Introduction: Cerebral venous sinus thrombosis associated with vaccine-induced immune thrombotic thrombocytopenia (CVST-VITT) is a severe disease with high mortality. There are few data on sex differences in CVST-VITT. The aim of our study was to investigate the differences in presentation, treatment, clinical course, complications, and outcome of CVST-VITT between women and men. Patients and methods: We used data from an ongoing international registry on CVST-VITT. VITT was diagnosed according to the Pavord criteria. We compared the characteristics of CVST-VITT in women and men. Results: Of 133 patients with possible, probable, or definite CVST-VITT, 102 (77%) were women. Women were slightly younger [median age 42 (IQR 28–54) vs 45 (28–56)], presented more often with coma (26% vs 10%) and had a lower platelet count at presentation [median (IQR) 50x109/L (28–79) vs 68 (30–125)] than men. The nadir platelet count was lower in women [median (IQR) 34 (19–62) vs 53 (20–92)]. More women received endovascular treatment than men (15% vs 6%). Rates of treatment with intravenous immunoglobulins were similar (63% vs 66%), as were new venous thromboembolic events (14% vs 14%) and major bleeding complications (30% vs 20%). Rates of good functional outcome (modified Rankin Scale 0-2, 42% vs 45%) and in-hospital death (39% vs 41%) did not differ. Discussion and conclusions: Three quarters of CVST-VITT patients in this study were women. Women were more severely affected at presentation, but clinical course and outcome did not differ between women and men. VITT-specific treatments were overall similar, but more women received endovascular treatment.
Details
- Database :
- OAIster
- Journal :
- Scutelnic , A , van de Munckhof , A , Krzywicka , K , van Kammen , M S , Lindgren , E , Cordonnier , C , Kleinig , T J , Field , T S , Poli , S , Lemmens , R , Middeldorp , S , Aaron , S , Borhani-Haghighi , A , Arauz , A , Kremer Hovinga , J A , Günther , A , Putaala , J , Wasay , M , Conforto , A B , de Sousa , D A , Jood , K , Tatlisumak , T , Ferro , J M , Coutinho , J M , Arnold , M , Heldner , M R , Antonenko , K , Mbroh , J , Brodard , J , Hooshmandi , E , Dizonno , V , Devroye , A , Ciccone , A , Wittstock , M , Zimmermann , J , Bode , F J , Skjelland , M , Duan , J , Hiltunen , S , Zuurbier , S M , Petruzzellis , M , Sharma , A R , Ghoreishi , A , Elkady , A , Negro , A , Gutschalk , A , Schoenenberger , S , Nagel , S , Buture , A , Cervera , A , Paiva Nunes , A , Romina Montané Baños , A , Tiede , A , Puthuppallil , A , Tuladhar , A M , Mengel , A , Medina , A , Hellström Vogel , Å , Tawa , A , Aujayeb , A , Ramasamy , B , Casolla , B , Lim Alvin Chew , B , Ziaadini , B , Varkey Maramattom , B , Buck , B , Zanferrari , C , Garcia-Esperon , C , Vayne , C , Legault , C , Jacobi , C , Pfrepper , C , Pelz , J , Wahl , C , Kern , R , Tracol , C , Soriano , C , Guisado-Alonso , D , Bougon , D , Bal , D , Sergio Zimatore , D , Michalski , D , Blacquiere , D , Johansson , E , Cuadrado-Godia , E , Sadeghi-Hokmabadi , E , Carrera , E , De Maistre , E , Saxhaug Kristoffersen , E , Bonneville , F , Geeraerts , T , Vuillier , F , Giammello , F , D’Onofrio , F , Grillo , F , Caparros , F , Susen , S , Maier , F , Tsivgoulis , G , Gulli , G , Frisullo , G , Franchineau , G , Cangür , H , Katzberg , H , Mozhdehipanah , H , Sibon , I , Baharoglu , M I , Masjuan , J , Brar , J , Payen , J F , Burrow , J , Fernandes , J , Octavio López Esparza , J , Oen , J , Schouten , J , Ng , K , Chatterton , S , Wronski , M , Althaus , K , Garambois , K , Derex , L , Puy , L , Poorsaadat , L , Valler , L , Januzi de Almeida Rocha , L , Humbertjean , L , Lebrato Hernandez , L , Murillo-Bo
- Notes :
- application/pdf, English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1417972915
- Document Type :
- Electronic Resource