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1. Effect of decentralising childhood tuberculosis diagnosis to primary health centre versus district hospital levels on disease detection in children from six high tuberculosis incidence countries: an operational research, pre-post intervention study

Author

Laurence, Borand, Agathe, de Lauzanne, Bunnet, Dim, Seyla, Heang, Sanary, Kaing, Chanty, Keang, Socheat, L.Y., Pichpiseth, Meas, Sovann, Nhoueng, Long, Pring, Vouchleang, Sreng, Song, Yin, Saren, Sovan, Chanvirak, Phan, Chanra, Chreng, Ratha, Khoun, Monicando, Rin, Sophea, Pal, Boraneath, Nang, Rathakrun, Pom, Tan Eang, Mao, Simoy, Chhim, Huot, Touch, Kosal, Suon, Saronn, Chum, Kimhong, Tok, Kimchorn, Pring, Satya, Krouch, Chean, Chok, Sunleng, Seun, Savtey, Phon, Mai, Nang, Kimda, Hun, Vanny, Hong, Dara, Sok, Kosal, Chea, Bunthoeun, Chheang, Rino, Sem, Lam, Lay, Haysan, Say, Pholly, Kem, Sreyphal, Meng, Sokheng, Phorn, Sreyvann, Him, Peakdey, Pheach, Dalai, Kive, Moeur, Sar, Sreydy, Kong, Seyha, Kong, Sreytouch, Yorn, Soam, Tes, Sophal, Kep, Seroeung HENG Thy, Leng, Savorn, Neak, Sim, Seng, Pheakna, Pay, Sithan, Suon, Sophanna, Chan, Dyna, Um, Savuth, Sin, Sam, Phan, Sarim, Kum, Sokheng, Khath, Pong, Phem, Seyha, Sok, Chanty, Ny, Van, Leim, Sereyvuth, Pich, Sengkry, Chheang, Nhin, Eang, Vannareth, Sao, Vannak, Sim, Sopheak, Som, Ney, Pong, Sokha, Van, Sreyleap, Seng, Vanna, Yoeurng, Kakada, Toem, Thida, Keo, Vuochny, Sem, Sophal, Veng, Chanthol, Rin, Vanny, Seang, Kiri, Lok, Khemra, Mao, Keovanna, Ouk, Maiya, Min, Suomun, Morm, Rattana, Koy, Sreypov, Chhann, Sreytouch, Set, Audrey, Amboua Schouame, Clifford, Babey, Masama, Eden Ngu, Etienne, Guenou, Sylvie, Kwedi Nolna, Douglas, Mbang Massom, Bernard Fortune, Melingui, Nadia, Nga Elomo, Moïse, Mvetumbo, Angeline, Nkembe, Krystel, Ebo, Albert, Kuate Kuate, Michelline, Choupa, Maggi, Mbede, Valerie, Donkeng, Nelly, Kamgaing, Jean-Voisin, Taguebue, Achille, Touha Yannick, Estelle, Abomo Zang, Rosette, Bakoa, Esperance, Mimbouombela Leger, Sabine, Eleme, Gabrielle, Eteme Marie, Thierry, Elouna Nkoa, Dieudonné, Ndzana, Christophe, Bitti, Olivier, Fotsing, Charlotte, Lani Boko, Mathieu, Mbonga, Ghislain Ulrich, Njakou Sagang, Innocent, Onomo, Charlotte, Essaga Hortense, Daniel Desiré, Mboudi Kouang, Léon, Eloundou, Helene, Kengne, Felix, Mbassi, Juliette, Bidjeme, Hortense, Toua Eteme, Nadege, Essama, Roger, Belinga Balla, Norbert, Tassi, Roline, Nguiko Elsa, Leonard, Mekongo, Fabien, Eyebe Ayissi, Francine Christelle, Biloa Anaba, Philomène, Nsom, Celestin Géraud, Yam Essola, Edwige Léa, Mame Moo, Noé, Makon, Arllette Rita, Nounkep Yanghu, Frank, Ebanga, Antoinette, Assiga Ntsama, Carlyle Sorelle, Kamguia Djuimsop, Diane, Mbabou, Marie, Maguip Abanda, Rosine Berthe, Nguemafouo Doummene, Amos, Mekone, Ngwankfu, Konfor Blessing, Jérome, Mimboe, Virginie, Tiona, Roland, Beleck, Sairou, Zam, Nicole, Adibone, Claude, Biaback Jean, Denis, Bessong, Gilbert, Aminou, Jeremie Pagnol, Bille Bonga, Aubin, Fotso Monkap, Epse NGON Annie, Hitekelek, Vitrice, Sebe, Leo, Makon, Marie, Ennah, Mpie, Paul Boyolo, Diane Viviane, Metchoum, Celin, Nzambe, Arnaud, Dado, Milobert, Mbengang, Marceline, Eyebi, Vanessa, Ngah, Alice, Mballa Batonga, Solange, Ayouba, Pierrette, Ebode, Majino, Mamou, Marguerite, Botomogne Bomba, Salametou, Ngnet, Augustine Florence, Essengue Ngono, Rolland, Odionoloba Charles, Bernice, Bisso, Suzy, Balemaken Ingrid, Marie Louise, Mandoki a Bilong, Gertrude, Ndeng Ayouba, Josue, Ngon, Roger, Aka Bony, Kacou Michel, Bah, Dro, Bakayoko, Rolande, Baki Aimee, Marie-France Larissa, Banga, Olivier, Bouzié, Kan, Brou, Pan, Coulibaly, Serge, Danho, Flavien, Deli, Alphonse, Dion, Bi, Do, Armand, Dohoun, William, Edjeme, Cathérine, Falé, Melissa, Gogoua Saulé, Constant, Kesse, Eric, Komena Auguste, Christian, Kouadio, Arkason, Kouame Abel, Raoul, Moh, Sandrine, Nguessan Marcelle, Bertine, Siloué, Nina, Soua, Cyrille Prisca, Yao Yapi, Timothée, Ouassa, Jacquemin, Kouakou, Eric, Balestre, Aurélie, Beuscart, Aurélie, Charpin, Marc, D'elbee, Hélène, Font, Basant, Joshi, Nicolas, Koskas, Olivier, Marcy, Estelle, Occelli, Joanna, Orne-Gliemann, Julien, Poublan, Elodie, Vernoux, Maryline, Bonnet, Savine, Chauvet, Manon, Lounnas, Guillaume, Breton, Pierre-Yves, Norval, Sheyla, Cassy, Verna, Chambal, Valter, Chiúle, Supinho, Chimbanje, Saniata, Cumbe, Mércia, Matsinhe, Celso, Khosa, Nairo, Mabote, Salvador, Machava, Emelva, Machonisse, Verónica, Macuácua, Denise, Milice, Jorge, Ribeiro, Elcídio, Tivane, Dorlim, Uetela, Yara, Voss de Lima, Américo, Zandamela, Alcina, Zita, Ivan, Manhiça, Benedita, José, Dalila, Rego, Chris, Buck W., Kapoli, Kasembe, Atália, Massangaie, Assa, Sitoe, Ambostique, Argola, Césio, Miambo, Presequila, Nhatsave, Gilda, Sitoe, Charifito, Vesta, Salvador, Dimande, Lázaro, Mazembe, Nilza, Amade, Manuela, Chavela, Nomsa, Macheque, Salomão, Comé, Eulália, Machava, Narciso, Mucavele, Jacinto, Nhabanga, Marlene, Nicolau, Natércia, Simbine, Lina, Uendela, Micaela, Juaio, Abiba, Saíde, Naira, Macie, Fernando, Mondlane, Stélio, Simango, Prince, Beyan, Benjamin M, Flomo, Abubakarr, Jalloh Joseph, Ishmael, Kamara, Monica G, Koroma, Mohamed, Lamin, Lena, Matata, Ross, Mugisha Jacob, Christiana M, Senesie, Sheriff, S.E.S.A.Y., Egerton, Tamba Kamara, Ayeshatu, Mustapha, Lynda, Foray, Sandra, Agondeze, Agnes, Kobusingye, Mastula, Nanfuka, Faith, Namulinda, Eric, Wobudeya, Rinah, Arinaitwe, Rodney, Kaitano, Martin, Kasujja, Juliet, Mwanga-Amumpaire, Evans, Mwesigwa, Naome, Natukunda, Simpson, Nuwamanya, Miria, Nyangoma, Patrick, Orikiriza, Johnbosco, Tumwijukye, Esther, Turyashemererwa, Nyehangane, Dan, Mugisha, Ivan, Winnie, Biryeri, George, Naika, Robert, Ongwara O., Allen, Najjuko, Augustine, Kayiira, Samuel, Yairo, Immaculate, Tumwebaze, Goreth, Nalwoga, Paul, Nsiyaleta, Annet, Agaba, Martin, Mpimbaza M., Norbert, Akampurira, Agatha, Tugumisirize, Evans, Ariyo, Julius, Agaba, Yovita, Natukunda, Nelson, Musazi, Edmund, Musinguzi, Brown, Baluku Julius, Moorine, Sekadde, Stavia, Turyahabwe, Chishala, Chabala, Luis, Cuevas, Christophe, Delacourt, Steve, Graham, Malgorzata, Grzemska, Sabine, Verkuijl, Anneke, Hesseling, Elizabeth, Maleche-Obimbo, Mark, Nicol, Wobudeya, Eric, Nanfuka, Mastula, Ton Nu Nguyet, Minh Huyen, Taguebue, Jean-Voisin, Moh, Raoul, Breton, Guillaume, Khosa, Celso, Borand, Laurence, Mwanga-Amumpaire, Juliet, Mustapha, Ayeshatu, Nolna, Sylvie Kwedi, Komena, Eric, Mugisha, Jacob Ross, Natukunda, Naome, Dim, Bunnet, de Lauzanne, Agathe, Cumbe, Saniata, Balestre, Eric, Poublan, Julien, Lounnas, Manon, Ngu, Eden, Joshi, Basant, Norval, Pierre-Yves, Terquiem, Etienne Leroy, Turyahabwe, Stavia, Foray, Lynda, Sidibé, Souleymane, Manhiça, Ivan, Sekadde, Moorine, Detjen, Anne, Verkuijl, Sabine, Mao, Tan Eang, Orne-Gliemann, Joanna, Bonnet, Maryline, and Marcy, Olivier

Published
2024
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2. Cost-effectiveness and budget impact of decentralising childhood tuberculosis diagnosis in six high tuberculosis incidence countries: a mathematical modelling study

Author

Arlt-Hilares, Doris, Balestre, Eric, Banga, Marie-France, Bénard, Antoine, Bernard, Tanguy, Bonnet, Maryline, Borand, Laurence, Breton, Guillaume, Bunnet, Dim, Chateau, Paul-Damien, Cumbe, Saniata, d’Elbée, Marc, de Lauzanne, Agathe, Dodd, Peter James, Harker, Martin, Huyen Ton Nu Nguyet, Minh, Kaing, Sanary, Khosa, Celso, Komena, Eric, Koroma, Monica, Kwedi Nolna, Sylvie, Mafirakureva, Nyashadzaishe, Mao, Tan Eang, Marcy, Olivier, Mbang Masson, Douglas, Moh, Raoul, Mugisha, Jacob, Mustapha, Ayeshatu, Mwanga-Amumpere, Juliet, Nanfuka, Mastula, Natukunda, Naome, Orne-Gliemann, Joanna, Ouattara, Eric, Poublan, Julien, Sohn, Hojoon, Taguebue, Jean-Voisin, Tulinawe, Immaculate, Voss de Lima, Yara, Wittwer, Jérôme, Wobudeya, Eric, Nolna, Sylvie Kwedi, and Dodd, Peter J.

Published
2024
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3. Effect of systematic tuberculosis detection on mortality in young children with severe pneumonia in countries with high incidence of tuberculosis: a stepped-wedge cluster-randomised trial

Author

Marcy, Olivier, Serre, Angeline, Badrichani, Anne, Razafimanantsoa, Manoa, Poublan, Julien, Vessière, Aurélia, Roucher, Clémentine, Occelli, Estelle, Beuscart, Aurélie, Charpin, Aurélie, Habiyambere, Gemma, Mesnier, Salomé, Balestre, Eric, Bhatta, Bandana, Maillard, Anne-Laure, Orne-Gliemann, Joanna, Baillet, Emmanuelle, Koskas, Nicolas, D'Elbée, Marc, Gabillard, Delphine, Font, Hélène, Huyen, Minh, Bonnet, Maryline, Lounnas, Manon, Espérou, Hélène, Couffin-Cadiergues, Sandrine, Kuppers, Alexis, Hamze, Benjamin, BORAND, Laurence, de LAUZANNE, Agathe, DIM, Bunnet, Keang, Chanthy, PRING, Long, YIN, Song, SARITH, Channimol, PHAN, Chanvirak, NHEUONG, Sovann, LY, Socheat, KAING, Sanary, SRENG, Vouchleang, LUN, Elen, SAY, Leakhena, SUOM, Sophea, FERHY, Romyka, SO, Dina, BORN, Sorunna, PAL, Sophea, NANG, Boraneath, MAO, Tan Eang, KIM, Ang, Srey, Viso, Kan, Piseth, Hout, leakhena, Ith, Samnang, Oum, Sophany, Sau, Sokunvadhana, Ho, Kim Heang, Kith, Daronic, Nuch, Nathara, Horm, Chhun Leang, Sophon, Cheameas, Roeungdeth, Bosba, MENG, Chhay, RITH, Ravin, PHY, Samnang, SOR, Chanchetra, SAO, Voleak, KHAT, Sophea, MAK, Bunthoeun, UY, Angkeaborin, KHAY, Sreyny, SOM, Kimsan, HACH, rongvirak, SOK, Hay, KUON, Sotheavy, HENG, Synatt, SENG, Amara, NIM, Sopheak, PAN, Reach, KIM, Srean, SREY LEAP, Keo, NET, Bormey, NOUN, Viccheka, LAY, Daven, MANY, Chhaing, Seng, Socheata, Ly, Vuthy, So, Saran, Oun, Sovutthik, CHEY, Sopheap, CHHEA, Rattany, BAONG, Lydeth, THOUNG, Vanna, KHEANG, Chanrithea, BY, Borady, Nguon, Vathanak, MEACH, Eksophea, Tek, Sopheak, Ngeav, Sina, Lun, Tetra, HEM, Deth, CHUT, Nayreang, SARIK, Setha, NANG, Hgekkoung, MEACH, Mengnean, SRENG, Sopal, SAR, Dara, KIN, Rathana, ROS, Phoran, DORN, Chenda, KAK, Chansy, Sambath, Srey Leak, Son, Leakhena, Bin, Linda, Pengong, Eangnay, Pol, Sokha, Khutsorn, Samnang, Seang, Sorsophea, Soun, Virak, Vong, Vuthy, Khoeung, Chandara, Um, Panha, Bou, Sokunthea, Song Pich, Sarin, Nim, Puthy, Khat, Sopheak, Ban Si, Nuon, Ream, Sovannodom, Ing, Sim, Chann, Phanith, Ngeth, Samrith, Sun, Marina, Chhoeung, Sokea, Sean, Soeun, Prak, Ratanak, Taguebue, Jean-Voisin, Kwedi Nolna, Sylvie, Amboua Schouame Onambele, Audrey, Hycenth, Numfor, Melingui, Bernard, Nkembe Medounmga, Angeline, Hougnang Tatmi, Luciole, Etemgoua, Nathalie, Kouesso, Vanessa, Bugin, Jean, Nzedjom, Celestine, Ngoya, Roger, Eyike, Jules, Loudjom, Elyse, Lonsti, Roger, Dang, Ladi, Bintar, Edward, Njayong, Chantal, Ngonsoa O, Cinthia, Ndzeukap, Isabelle, Dzoyem, Pascaline, Dzokou, Clémentine, Dindo, Berthe, Moh, Raoul, Komena, Eric Auguste, Aka Bony, Roger, Kouadio, Christian, Danho, Serge, Goli, Melissa, Folquet, Madeleine, Itchy, Max Valère, Sidibé, Abdel, Cissé, Lancina, Ouattara, Joseph, Konaté, Mamadou, Amon-Tanoh Dick, Flore, Cardena, Melissa, Adonis-Koffi, Laurence, Eugenie, Djabia, Kouamé, Ferdinand, Menan, Hervé, Inwoley, André, Ouassa, Timothée, Nguessan, Marcelle Sandrine, Khosa, Celso, Cumbe, Saniata, Manhiça, Emelva, Zitha, Alcina, Chiúle, Valter, Muxanga, Eva, Gune, Irene, Lima, Yara, Ribeiro, Jorge, Mavale, Sandra, Chilundo, Josina, Maxanguana, Felismina, Morais, Natália, Manhiça, Julieta, Give, Josefina, Atumane, Jafito, Lucas, Gelson, Thai, Arsénio, Chave, Adélio, Rego, Dalila, Guambe, Lúcia, Issa, Faiaz, Carneiro, Rosa, Pene, Neusa, Florindo, Natércia, Machel, Dália, Cumbane, Cecília, Mendes, Helena, Kitungwa, Mule, Muianga, Valdo, Tamele, Humberto, Sulude, Adelino, Mabota, Roda, Comandante, Herquéria, Massangaie, Abelardo, Wobudeya, Eric, Businge, Gerald Bright, Namulinda, Faith, Sserunjogi, Robert, Nassozi, Rashidah, Barungi, Charlotte, Aanyu, Hellen, Muwonge, Doreen, Kagoya, Eva, Aciparu, Serene, Chemutai, Sophia, Ntambi, Samuel, Wasswa, Amir, Nangozi, Juliet, Tagoola, Abner, Mbekeka, Prossy, Kenneth, Sajja, Lubega, John Paul, Nassali, Aidah, Tagobera, Jessica, Agwang, Christine, Kalembe, Florence, Ajambo, Annet, Aguti, Elizabeth, Kasibante, Samuel, Matende, Henry, Odongo, Israel Owen, Mwanga Amumpaire, Juliet, Natukunda, Naome, Ngabirano, Gertrude, Kakwenza, Paul, Nuwamanya, Simpson, Nyangoma, Miria, Nabbuto, Jane, Abok, Florence, Arinaitwe, Rinah, Birungi, Diana, Mwesigwa, Evans, Atwine, Daniel, Mbega, Hassan, Orikiriza, Patrick, Taremwa, Ivan, Turyashemererwa, Esther, Derrick, Hope, Nyehangane, Dan, Kaitano, Rodney, Logoose, Susan, Businge, Steven, Ntambi, Charles, Mugabi, Jerome, Mzee, John, Besigye, Julius, Kanzira, Saul, Turyatemba, Phionah, Twebaze, Florence, Chabala, Chishala, Mulenga, Veronica, Shankalala, Perfect, Hambulo, Chimuka, Kapotwe, Vincent, Ngambi, Marjory, Kasakwa, Kunda, Chirwa, Uzima, Kapula, Chifunda, Zulu, Susan, Nawakwi, Grace, Siasulingana, Teddy, Chilonga, Jessy, Chimbini, Maria, Chilanga, Mutinta, Nduna, Bwendo, Inambao, Muleya, Mwambazi, Mwate, Halende, Barbra, Mumba, Wyclef, Mankunshe, Endreen, Silavwe, Maureen, Chakopo, Moses, Moono, Roy, Mwanga-Amumpaire, Juliet, De Lauzanne, Agathe, Dim, Bunnet, Tiogouo Ngouana, Emeline, Folquet Amorrissani, Madeleine, Cisse, Lassina, Amon Tanoh Dick, Flore, Komena, Eric A, Businge, Gerald, Kim, Ang, Kheang, Chanrithea, Maleche-Obimbo, Elizabeth, Seddon, James A, Mao, Tan Eang, Graham, Stephen M, Delacourt, Christophe, and Borand, Laurence

Published
2023
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4. Inappropriate antibiotic prescribing and its determinants among outpatient children in 3 low- and middle-income countries: A multicentric community-based cohort study

Author

Ardillon, Antoine, Ramblière, Lison, Kermorvant-Duchemin, Elsa, Sok, Touch, Zo, Andrianirina Zafitsara, Diouf, Jean-Baptiste, Long, Pring, Lach, Siyin, Sarr, Fatoumata Diene, Borand, Laurence, Cheysson, Felix, Collard, Jean-Marc, Herindrainy, Perlinot, de Lauzanne, Agathe, Vray, Muriel, Delarocque-Astagneau, Elisabeth, Guillemot, Didier, and Huynh, Bich-Tram

Subjects
Drug resistance in microorganisms -- Prevention, Prescription writing -- Methods, Children -- Health aspects, Ambulatory medical care -- Usage, Antibiotics -- Dosage and administration, Biological sciences
Abstract

Background Antibiotic resistance is a global public health issue, particularly in low- and middle-income countries (LMICs), where antibiotics required to treat resistant infections are not affordable. LMICs also bear a disproportionately high burden of bacterial diseases, particularly among children, and resistance jeopardizes progress made in these areas. Although outpatient antibiotic use is a major driver of antibiotic resistance, data on inappropriate antibiotic prescribing in LMICs are scarce at the community level, where the majority of prescribing occurs. Here, we aimed to characterize inappropriate antibiotic prescribing among young outpatient children and to identify its determinants in 3 LMICs. Methods and findings We used data from a prospective, community-based mother-and-child cohort (BIRDY, 2012 to 2018) conducted across urban and rural sites in Madagascar, Senegal, and Cambodia. Children were included at birth and followed-up for 3 to 24 months. Data from all outpatient consultations and antibiotics prescriptions were recorded. We defined inappropriate prescriptions as antibiotics prescribed for a health event determined not to require antibiotic therapy (antibiotic duration, dosage, and formulation were not considered). Antibiotic appropriateness was determined a posteriori using a classification algorithm developed according to international clinical guidelines. We used mixed logistic analyses to investigate risk factors for antibiotic prescription during consultations in which children were determined not to require antibiotics. Among the 2,719 children included in this analysis, there were 11,762 outpatient consultations over the follow-up period, of which 3,448 resulted in antibiotic prescription. Overall, 76.5% of consultations resulting in antibiotic prescription were determined not to require antibiotics, ranging from 71.5% in Madagascar to 83.3% in Cambodia. Among the 10,416 consultations (88.6%) determined not to require antibiotic therapy, 25.3% (n = 2,639) nonetheless resulted in antibiotic prescription. This proportion was much lower in Madagascar (15.6%) than in Cambodia (57.0%) or Senegal (57.2%) (p < 0.001). Among the consultations determined not to require antibiotics, in both Cambodia and Madagascar the diagnoses accounting for the greatest absolute share of inappropriate prescribing were rhinopharyngitis (59.0% of associated consultations in Cambodia, 7.9% in Madagascar) and gastroenteritis without evidence of blood in the stool (61.6% and 24.6%, respectively). In Senegal, uncomplicated bronchiolitis accounted for the greatest number of inappropriate prescriptions (84.4% of associated consultations). Across all inappropriate prescriptions, the most frequently prescribed antibiotic was amoxicillin in Cambodia and Madagascar (42.1% and 29.2%, respectively) and cefixime in Senegal (31.2%). Covariates associated with an increased risk of inappropriate prescription include patient age greater than 3 months (adjusted odds ratios (aOR) with 95% confidence interval (95% CI) ranged across countries from 1.91 [1.63, 2.25] to 5.25 [3.85, 7.15], p < 0.001) and living in rural as opposed to urban settings (aOR ranged across countries from 1.83 [1.57, 2.14] to 4.40 [2.34, 8.28], p < 0.001). Diagnosis with a higher severity score was also associated with an increased risk of inappropriate prescription (aOR = 2.00 [1.75, 2.30] for moderately severe, 3.10 [2.47, 3.91] for most severe, p < 0.001), as was consultation during the rainy season (aOR = 1.32 [1.19, 1.47], p < 0.001). The main limitation of our study is the lack of bacteriological documentation, which may have resulted in some diagnosis misclassification and possible overestimation of inappropriate antibiotic prescription. Conclusion In this study, we observed extensive inappropriate antibiotic prescribing among pediatric outpatients in Madagascar, Senegal, and Cambodia. Despite great intercountry heterogeneity in prescribing practices, we identified common risk factors for inappropriate prescription. This underscores the importance of implementing local programs to optimize antibiotic prescribing at the community level in LMICs., Author(s): Antoine Ardillon 1,2, Lison Ramblière 1,2, Elsa Kermorvant-Duchemin 3, Touch Sok 4, Andrianirina Zafitsara Zo 5, Jean-Baptiste Diouf 6, Pring Long 7, Siyin Lach 7, Fatoumata Diene Sarr 8, [...]

Published
2023
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5. Rapid decrease in IL-1Ra and IP-10 plasma levels following tuberculosis treatment initiation

Author

Polidy, Pean, primary, Affi, Roseline, additional, Chazalon, Corine, additional, Soumahoro, Ben Cheick, additional, Gabillard, Delphine, additional, Bunnet, Dim, additional, Borand, Laurence, additional, Moh, Raoul, additional, Anglaret, Xavier, additional, Blanc, François-Xavier, additional, Girard, Pierre-Marie, additional, Carcelain, Guislaine, additional, Laureillard, Didier, additional, and Weiss, Laurence, additional

Published
2024
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7. Impact of systematic early tuberculosis detection using Xpert MTB/RIF Ultra in children with severe pneumonia in high tuberculosis burden countries (TB-Speed pneumonia): a stepped wedge cluster randomized trial

Author

Vessière, Aurélia, Font, Hélène, Gabillard, Delphine, Adonis-Koffi, Laurence, Borand, Laurence, Chabala, Chishala, Khosa, Celso, Mavale, Sandra, Moh, Raoul, Mulenga, Veronica, Mwanga-Amumpere, Juliet, Taguebue, Jean-Voisin, Eang, Mao Tan, Delacourt, Christophe, Seddon, James A., Lounnas, Manon, Godreuil, Sylvain, Wobudeya, Eric, Bonnet, Maryline, and Marcy, Olivier

Published
2021
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12. Plugging the leaks: antibiotic resistance at human–animal interfaces in low‐resource settings

Author

Nadimpalli, Maya L, primary, Stegger, Marc, additional, Viau, Roberto, additional, Yith, Vuthy, additional, de Lauzanne, Agathe, additional, Sem, Nita, additional, Borand, Laurence, additional, Huynh, Bich‐tram, additional, Brisse, Sylvain, additional, Passet, Virginie, additional, Overballe‐Petersen, Søren, additional, Aziz, Maliha, additional, Gouali, Malika, additional, Jacobs, Jan, additional, Phe, Thong, additional, Hungate, Bruce A, additional, Leshyk, Victor O, additional, Pickering, Amy J, additional, Gravey, François, additional, Liu, Cindy M, additional, Johnson, Timothy J, additional, Le Hello, Simon, additional, and Price, Lance B, additional

Published
2023
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15. Mortality and its determinants in antiretroviral treatment-naive HIV-infected children with suspected tuberculosis: an observational cohort study

Author

Ay, Sao Sarady, Borand, Laurence, Chan, Malen, Chea, Phalla, Dim, Bunnet, Goyet, Sophie, Marcy, Olivier, Men, Nimul Roat, Pheng, Phearavin, Ramsay, Susan, Suom, Sophea, Tarantola, Arnaud, Te, Naisim, Than, Sreymom, Ung, Sovannary, Chhuk, Chorn, Huot, Chantheany, Kath, Sang Han, Khin, Sokoeun, Kim, Peou, Lim, Kim Eng, Lim, Phary, Lim, Vannareth, Nav, Yany, Pich, Boren, Tuy, Sotharin, Ung, Vibol, Chea, Phal, Chhraing, Sengtray, Chuop, Bophal, Hem, Ramy, Heng, Phanoeurn, Huon, Seng Hap, Khum, Sokhorn, Liv, Thear, Ly, Vichea, Moch, Makara, Neou, Leakheana, Rey, Phanith, Sath, Vina, Sun, Nopheavann, Chat, Pheron, Srey, Viso, Chheang, Sitha, Hor, Putchhat, Oum, Manory, Keo, Monorea, Kou, Sokchea, Cheng, Sokleaph, Kerleguer, Alexandra, Gomgnimbou, Michel, Kabore, Antoinette, Millogo, Anselme, Nacro, Boubacar, Nikiema, Zakari, Ouedraogo, Abdul Salam, Saidou, Sawadogo, Nouctara, Moumini, Sangare/Ouattara, Diane Ursule, Sanogo, Bintou, Sib Sié, Edgard, Zingué, Dézémon, Abiguide, Roger Ngoya, Assene Ngo'o, Patrice, Ateba Ndongo, Francis, Balla, Suzanne, Bolyse Mbouchong, Verlaine, Ehongo Amanya, Jean Marie, Eyangoh, Sara, Kaiyven, Afi Leslie, Koki Ndombo, Paul, Kokola Bayanak, Samuel Walter, Mapah Kampaing, Marie Josée, Mangoya, Elizabeth, Mvogo, Minkala, Ndongo, Jean Pierre, Ngassam, Laurence, Nanda, Francine, Ndjantou, Sylviane, Ndongo, Jean Audrey, Njind Nkoum, Marcelle, Njom Lend, Anne Esther, Nkembe, Angeline, Oyanche, Marie Flore, Taguebue, Jean-Voisin, Tejiokem, Mathurin, Tetang-Moyo, Suzy, Zebaze, Sylvie Georgette, Nguyen, Thi Oanh, Nguyen, Thi Ngoc Lan, Quillet, Catherine, Quoc, Khanh Lê, To, My Huong, Tran, Thi Kim Phung, Do, Chau Giang, Nguyen, Duc Bang, Nguyen, Ngo Vi Vi, Nguyen, Thi Hieu, Nguyen, Thi Thanh Thanh, Tran, Ngoc Duong, Vo, Duy An, Dang, Thi Xuan Lan, Do, Thi Kim Phuong, Dang, Thi Thanh Tuyen, Nguyen, Hoang Chau, Pham, Ngoc Tuong Vy, Truong, Huu Khanh, Do, Chau Viet, Huynh, Bich Ngoc, Le, Thi Thanh Thuy, Nguyen, Thi Thu Hiep, Tran, Ngoc Luu, Vu, Thien An, Tran, Huu Loc, Nguyen, Manh Hoang, Nguyen, Ngoc Lan, Van Nguyen, Thi Cao, Pham, Thu Hang, Phan, Dinh Quyen, Vo, Thi Ha, Truong, Xuan Lien, Vu, Xuan Thinh, Blanche, Stéphane, Delacourt, Christophe, Berteloot, Laureline, Carcelain, Guislaine, Godreuil, Sylvain, Fournier-Nicolle, Isabelle, Msellati, Philippe, Truong Huu, Khanh, Do Chau, Viet, Tran Ngoc, Duong, Ateba-Ndongo, Francis, Tetang-Ndiang, Suzie, and Neou, Leakhena

Published
2018
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16. Meat and Fish as Sources of Extended-Spectrum [beta]-Lactamase-Producing Escherichia coli, Cambodia

Author

Nadimpalli, Maya, Vuthy, Yith, de Lauzanne, Agathe, Fabre, Laetitia, Criscuolo, Alexis, Gouali, Malika, Huynh, Bich-Tram, Naas, Thierry, Phe, Thong, Borand, Laurence, Jacobs, Jan, Kerleguer, Alexandra, Piola, Patrice, Guillemot, Didier, Hello, Simon Le, and Delarocque-Astagneau, Elisabeth

Subjects
Lactams -- Contamination, Beta lactamases, Public health, Escherichia coli, Microbial drug resistance, Backup software, Aminoglycosides, Hospital patients, Resveratrol, Cephalosporins, Drug resistance, Genocide, Health
Abstract

In Europe, evidence for the spread of extended-spectrum [beta]-lactamase (ESBL)-producing Escherichia coli from animals to humans via food is unclear (1). Few studies have been conducted in low- and middle-income [...]

Published
2019
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17. Traditional medicine consumption in postpartum for HBV-infected women enrolled in the ANRS 12345 TA PROHM study in Cambodia

Author

Moeung, Sotheara, primary, Chassagne, François, additional, Goyet, Sophie, additional, Nhoeung, Sovann, additional, Sun, Lynecta, additional, Yang, Dorina, additional, Vilhem, Steve, additional, Dim, Bunnet, additional, Ly, Socheat, additional, Sov, Linda, additional, Sreng, Vouchleang, additional, Chorn, Sokda, additional, Chhun, Samsorphea, additional, Borand, Laurence, additional, Kim, Sothea, additional, and Segeral, Olivier, additional

Published
2023
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18. Evaluation of hepatitis B core-related antigen rapid test (HBcrAg-RDT) to identify HBV-infected women eligible for peripartum antiviral prophylaxis in resource-limited countries

Author

Vincent, Jeanne Perpétue, primary, Segeral, Olivier, additional, Kone, Amariane, additional, Borand, Laurence, additional, Adoukara, Jean-Pierre, additional, Kania, Dramane, additional, Tiendrebeogo, Abdoul, additional, Pivert, Adeline, additional, Sovan, Saren, additional, Yang, Jee-Seon, additional, Delvallez, Gauthier, additional, Fabiani, Françoise Lunel, additional, Tanaka, Yasuhito, additional, and Shimakawa, Yusuke, additional

Published
2023
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19. Severe bacterial neonatal infections in Madagascar, Senegal, and Cambodia: A multicentric community-based cohort study

Author

Huynh, Bich-Tram, Kermorvant-Duchemin, Elsa, Chheang, Rattanak, Randrianirina, Frederique, Seck, Abdoulaye, Hariniaina Ratsima, Elisoa, Andrianirina, Zafitsara Zo, Diouf, Jean-Baptiste, Abdou, Armya Youssouf, Goyet, Sophie, Ngo, Véronique, Lach, Siyin, Pring, Long, Sok, Touch, Padget, Michael, Sarr, Fatoumata Diene, Borand, Laurence, Garin, Benoit, Collard, Jean-Marc, Herindrainy, Perlinot, de Lauzanne, Agathe, Vray, Muriel, Delarocque-Astagneau, Elisabeth, and Guillemot, Didier

Subjects
Infants -- Patient outcomes, Infants (Newborn) -- Diseases, Drug resistance in microorganisms -- Research, Bacterial infections -- Statistics -- Risk factors -- Drug therapy, Pediatric research, Biological sciences
Abstract

Background Severe bacterial infections (SBIs) are a leading cause of neonatal deaths in low- and middle-income countries (LMICs). However, most data came from hospitals, which do not include neonates who did not seek care or were treated outside the hospital. Studies from the community are scarce, and few among those available were conducted with high-quality microbiological techniques. The burden of SBI at the community level is therefore largely unknown. We aimed here to describe the incidence, etiology, risk factors, and antibiotic resistance profiles of community-acquired neonatal SBI in 3 LMICs. Methods and findings The BIRDY study is a prospective multicentric community-based mother and child cohort study and was conducted in both urban and rural areas in Madagascar (2012 to 2018), Cambodia (2014 to 2018), and Senegal (2014 to 2018). All pregnant women within a geographically defined population were identified and enrolled. Their neonates were actively followed from birth to 28 days to document all episodes of SBI. A total of 3,858 pregnant women (2,273 (58.9%) in Madagascar, 814 (21.1%) in Cambodia, and 771 (20.0%) in Senegal) were enrolled in the study, and, of these, 31.2% were primigravidae. Women enrolled in the urban sites represented 39.6% (900/2,273), 45.5% (370/814), and 61.9% (477/771), and those enrolled in the rural sites represented 60.4% (1,373/2,273), 54.5% (444/814), and 38.1% (294/771) of the total in Madagascar, Cambodia, and Senegal, respectively. Among the 3,688 recruited newborns, 49.6% were male and 8.7% were low birth weight (LBW). The incidence of possible severe bacterial infection (pSBI; clinical diagnosis based on WHO guidelines of the Integrated Management of Childhood Illness) was 196.3 [95% confidence interval (CI) 176.5 to 218.2], 110.1 [88.3 to 137.3], and 78.3 [59.5 to 103] per 1,000 live births in Madagascar, Cambodia, and Senegal, respectively. The incidence of pSBI differed between urban and rural sites in all study countries. In Madagascar, we estimated an incidence of 161.0 pSBI per 1,000 live births [133.5 to 194] in the urban site and 219.0 [192.6 to 249.1] pSBI per 1,000 live births in the rural site (p = 0.008). In Cambodia, estimated incidences were 141.1 [105.4 to 189.0] and 85.3 [61.0 to 119.4] pSBI per 1,000 live births in urban and rural sites, respectively (p = 0.025), while in Senegal, we estimated 103.6 [76.0 to 141.2] pSBI and 41.5 [23.0 to 75.0] pSBI per 1,000 live births in urban and rural sites, respectively (p = 0.006). The incidences of culture-confirmed SBI were 15.2 [10.6 to 21.8], 6.5 [2.7 to 15.6], and 10.2 [4.8 to 21.3] per 1,000 live births in Madagascar, Cambodia, and Senegal, respectively, with no difference between urban and rural sites in each country. The great majority of early-onset infections occurred during the first 3 days of life (72.7%). The 3 main pathogens isolated were Klebsiella spp. (11/45, 24.4%), Escherichia coli (10/45, 22.2%), and Staphylococcus spp. (11/45, 24.4%). Among the 13 gram-positive isolates, 5 were resistant to gentamicin, and, among the 29 gram-negative isolates, 13 were resistant to gentamicin, with only 1 E. coli out of 10 sensitive to ampicillin. Almost one-third of the isolates were resistant to both first-line drugs recommended for the management of neonatal sepsis (ampicillin and gentamicin). Overall, 38 deaths occurred among neonates with SBI (possible and culture-confirmed SBI together). LBW and foul-smelling amniotic fluid at delivery were common risk factors for early pSBI in all 3 countries. A main limitation of the study was the lack of samples from a significant proportion of infants with pBSI including 35 neonatal deaths. Without these samples, bacterial infection and resistance profiles could not be confirmed. Conclusions In this study, we observed a high incidence of neonatal SBI, particularly in the first 3 days of life, in the community of 3 LMICs. The current treatment for the management of neonatal infection is hindered by antimicrobial resistance. Our findings suggest that microbiological diagnosis of SBI remains a challenge in these settings and support more research on causes of neonatal death and the implementation of early interventions (e.g., follow-up of at-risk newborns during the first days of life) to decrease the burden of neonatal SBI and associated mortality and help achieve Sustainable Development Goal 3., Author(s): Bich-Tram Huynh 1,2,*, Elsa Kermorvant-Duchemin 3, Rattanak Chheang 4, Frederique Randrianirina 5, Abdoulaye Seck 6, Elisoa Hariniaina Ratsima 5, Zafitsara Zo Andrianirina 7, Jean-Baptiste Diouf 8, Armya Youssouf Abdou [...]

Published
2021
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20. Simplified Criteria to Assess Long-Term Antiviral Treatment Indication in Chronic HBV-Infected Pregnant Women in Cambodia.

Author

Yang, Jee-Seon, Sovann, Saren, Shimakawa, Yusuke, Nhoueng, Sovann, Dim, Bunnet, Vong, Chanlina, Sann, Channa, Guillebaud, Julia, Vann, Darapolin, Touch, Bunrith, Chea, Hyna, Phirum, Wathanak Pisey Choupoan, Rosenthal, Eric, Paul, Christelle, Khun, Leangchhun, Yay, Chantana, Laurent, Denis, Chhun, Samsorphea, Borand, Laurence, and Segeral, Olivier

Subjects
PREGNANT women, HEPATITIS associated antigen, PREGNANCY
Abstract

Pregnant women identified to carry hepatitis B surface antigen (HBsAg) should be linked to care for the determination of the need for long-term antiviral therapy (LTT). We assessed the performance of simplified criteria, free from HBV DNA quantification, to select women eligible for LTT using different international guidelines as a reference. A retrospective analysis of HBV-infected pregnant women enrolled in the phase 4 ANRS TA-PROHM study was conducted in Cambodia. Sensitivity, specificity, and AUROC were computed to compare three simplified criteria (TREAT-B, HBcrAg/ALT, and TA-PROHM) with the American (AASLD) and European (EASL) guidelines as a reference. An additional assessment was performed at 6 months postpartum. Of 651 HBsAg-positive women, 209 (32%) received peripartum antiviral prophylaxis using tenofovir disoproxil fumarate (TDF). During pregnancy, 9% and 12% of women were eligible for LTT according to AASLD and EASL guidelines, respectively; 21% and 24% of women were eligible for prophylactic TDF and 2% and 5% in those ineligible (p < 0.001). Using the AASLD guidelines, the AUROC of TREAT-B, HBcrAg/ALT, and TA-PROHM scores were 0.88 (95%CI, 0.85–0.90), 0.90 (95%CI, 0.87–0.92), and 0.76 (95%CI, 0.73–0.80), respectively. Using the EASL guidelines, the AUROCs were lower: 0.73 (95%CI, 0.69–0.76), 0.76 (95%CI, 0.73–0.80), and 0.71 (95%CI, 0.67–0.74), respectively. Among those ineligible for prophylactic TDF, only 2% to 6% present an indication for LTT at 24 weeks postpartum. Few pregnant women are eligible for LTT, and the use of simplified criteria could represent an efficient triage option in decentralized areas to identify those negative for whom there is no urgent indication for LTT and focus on those positive for whom other exams must be conducted to confirm LTT indication. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Effect of systematic tuberculosis detection on mortality in young children with severe pneumonia in countries with high incidence of tuberculosis: a stepped-wedge cluster-randomised trial

Author

Marcy, Olivier, primary, Wobudeya, Eric, additional, Font, Hélène, additional, Vessière, Aurélia, additional, Chabala, Chishala, additional, Khosa, Celso, additional, Taguebue, Jean-Voisin, additional, Moh, Raoul, additional, Mwanga-Amumpaire, Juliet, additional, Lounnas, Manon, additional, Mulenga, Veronica, additional, Mavale, Sandra, additional, Chilundo, Josina, additional, Rego, Dalila, additional, Nduna, Bwendo, additional, Shankalala, Perfect, additional, Chirwa, Uzima, additional, De Lauzanne, Agathe, additional, Dim, Bunnet, additional, Tiogouo Ngouana, Emeline, additional, Folquet Amorrissani, Madeleine, additional, Cisse, Lassina, additional, Amon Tanoh Dick, Flore, additional, Komena, Eric A, additional, Kwedi Nolna, Sylvie, additional, Businge, Gerald, additional, Natukunda, Naome, additional, Cumbe, Saniata, additional, Mbekeka, Prossy, additional, Kim, Ang, additional, Kheang, Chanrithea, additional, Pol, Sokha, additional, Maleche-Obimbo, Elizabeth, additional, Seddon, James A, additional, Mao, Tan Eang, additional, Graham, Stephen M, additional, Delacourt, Christophe, additional, Borand, Laurence, additional, Bonnet, Maryline, additional, Marcy, Olivier, additional, Serre, Angeline, additional, Badrichani, Anne, additional, Razafimanantsoa, Manoa, additional, Poublan, Julien, additional, Roucher, Clémentine, additional, Occelli, Estelle, additional, Beuscart, Aurélie, additional, Charpin, Aurélie, additional, Habiyambere, Gemma, additional, Mesnier, Salomé, additional, Balestre, Eric, additional, Bhatta, Bandana, additional, Maillard, Anne-Laure, additional, Orne-Gliemann, Joanna, additional, Baillet, Emmanuelle, additional, Koskas, Nicolas, additional, D'Elbée, Marc, additional, Gabillard, Delphine, additional, Huyen, Minh, additional, Espérou, Hélène, additional, Couffin-Cadiergues, Sandrine, additional, Kuppers, Alexis, additional, Hamze, Benjamin, additional, BORAND, Laurence, additional, de LAUZANNE, Agathe, additional, DIM, Bunnet, additional, Keang, Chanthy, additional, PRING, Long, additional, YIN, Song, additional, SARITH, Channimol, additional, PHAN, Chanvirak, additional, NHEUONG, Sovann, additional, LY, Socheat, additional, KAING, Sanary, additional, SRENG, Vouchleang, additional, LUN, Elen, additional, SAY, Leakhena, additional, SUOM, Sophea, additional, FERHY, Romyka, additional, SO, Dina, additional, BORN, Sorunna, additional, PAL, Sophea, additional, NANG, Boraneath, additional, MAO, Tan Eang, additional, KIM, Ang, additional, Srey, Viso, additional, Kan, Piseth, additional, Hout, leakhena, additional, Ith, Samnang, additional, Oum, Sophany, additional, Sau, Sokunvadhana, additional, Ho, Kim Heang, additional, Kith, Daronic, additional, Nuch, Nathara, additional, Horm, Chhun Leang, additional, Sophon, Cheameas, additional, Roeungdeth, Bosba, additional, MENG, Chhay, additional, RITH, Ravin, additional, PHY, Samnang, additional, SOR, Chanchetra, additional, SAO, Voleak, additional, KHAT, Sophea, additional, MAK, Bunthoeun, additional, UY, Angkeaborin, additional, KHAY, Sreyny, additional, SOM, Kimsan, additional, HACH, rongvirak, additional, SOK, Hay, additional, KUON, Sotheavy, additional, HENG, Synatt, additional, SENG, Amara, additional, NIM, Sopheak, additional, PAN, Reach, additional, KIM, Srean, additional, SREY LEAP, Keo, additional, NET, Bormey, additional, NOUN, Viccheka, additional, LAY, Daven, additional, MANY, Chhaing, additional, Seng, Socheata, additional, Ly, Vuthy, additional, So, Saran, additional, Oun, Sovutthik, additional, CHEY, Sopheap, additional, CHHEA, Rattany, additional, BAONG, Lydeth, additional, THOUNG, Vanna, additional, KHEANG, Chanrithea, additional, BY, Borady, additional, Nguon, Vathanak, additional, MEACH, Eksophea, additional, Tek, Sopheak, additional, Ngeav, Sina, additional, Lun, Tetra, additional, HEM, Deth, additional, CHUT, Nayreang, additional, SARIK, Setha, additional, NANG, Hgekkoung, additional, MEACH, Mengnean, additional, SRENG, Sopal, additional, SAR, Dara, additional, KIN, Rathana, additional, ROS, Phoran, additional, DORN, Chenda, additional, KAK, Chansy, additional, Sambath, Srey Leak, additional, Son, Leakhena, additional, Bin, Linda, additional, Pengong, Eangnay, additional, Khutsorn, Samnang, additional, Seang, Sorsophea, additional, Soun, Virak, additional, Vong, Vuthy, additional, Khoeung, Chandara, additional, Um, Panha, additional, Bou, Sokunthea, additional, Song Pich, Sarin, additional, Nim, Puthy, additional, Khat, Sopheak, additional, Ban Si, Nuon, additional, Ream, Sovannodom, additional, Ing, Sim, additional, Chann, Phanith, additional, Ngeth, Samrith, additional, Sun, Marina, additional, Chhoeung, Sokea, additional, Sean, Soeun, additional, Prak, Ratanak, additional, Amboua Schouame Onambele, Audrey, additional, Hycenth, Numfor, additional, Melingui, Bernard, additional, Nkembe Medounmga, Angeline, additional, Hougnang Tatmi, Luciole, additional, Etemgoua, Nathalie, additional, Kouesso, Vanessa, additional, Bugin, Jean, additional, Nzedjom, Celestine, additional, Ngoya, Roger, additional, Eyike, Jules, additional, Loudjom, Elyse, additional, Lonsti, Roger, additional, Dang, Ladi, additional, Bintar, Edward, additional, Njayong, Chantal, additional, Ngonsoa O, Cinthia, additional, Ndzeukap, Isabelle, additional, Dzoyem, Pascaline, additional, Dzokou, Clémentine, additional, Dindo, Berthe, additional, Komena, Eric Auguste, additional, Aka Bony, Roger, additional, Kouadio, Christian, additional, Danho, Serge, additional, Goli, Melissa, additional, Folquet, Madeleine, additional, Itchy, Max Valère, additional, Sidibé, Abdel, additional, Cissé, Lancina, additional, Ouattara, Joseph, additional, Konaté, Mamadou, additional, Amon-Tanoh Dick, Flore, additional, Cardena, Melissa, additional, Adonis-Koffi, Laurence, additional, Eugenie, Djabia, additional, Kouamé, Ferdinand, additional, Menan, Hervé, additional, Inwoley, André, additional, Ouassa, Timothée, additional, Nguessan, Marcelle Sandrine, additional, Manhiça, Emelva, additional, Zitha, Alcina, additional, Chiúle, Valter, additional, Muxanga, Eva, additional, Gune, Irene, additional, Lima, Yara, additional, Ribeiro, Jorge, additional, Maxanguana, Felismina, additional, Morais, Natália, additional, Manhiça, Julieta, additional, Give, Josefina, additional, Atumane, Jafito, additional, Lucas, Gelson, additional, Thai, Arsénio, additional, Chave, Adélio, additional, Guambe, Lúcia, additional, Issa, Faiaz, additional, Carneiro, Rosa, additional, Pene, Neusa, additional, Florindo, Natércia, additional, Machel, Dália, additional, Cumbane, Cecília, additional, Mendes, Helena, additional, Kitungwa, Mule, additional, Muianga, Valdo, additional, Tamele, Humberto, additional, Sulude, Adelino, additional, Mabota, Roda, additional, Comandante, Herquéria, additional, Massangaie, Abelardo, additional, Businge, Gerald Bright, additional, Namulinda, Faith, additional, Sserunjogi, Robert, additional, Nassozi, Rashidah, additional, Barungi, Charlotte, additional, Aanyu, Hellen, additional, Muwonge, Doreen, additional, Kagoya, Eva, additional, Aciparu, Serene, additional, Chemutai, Sophia, additional, Ntambi, Samuel, additional, Wasswa, Amir, additional, Nangozi, Juliet, additional, Tagoola, Abner, additional, Kenneth, Sajja, additional, Lubega, John Paul, additional, Nassali, Aidah, additional, Tagobera, Jessica, additional, Agwang, Christine, additional, Kalembe, Florence, additional, Ajambo, Annet, additional, Aguti, Elizabeth, additional, Kasibante, Samuel, additional, Matende, Henry, additional, Odongo, Israel Owen, additional, Mwanga Amumpaire, Juliet, additional, Ngabirano, Gertrude, additional, Kakwenza, Paul, additional, Nuwamanya, Simpson, additional, Nyangoma, Miria, additional, Nabbuto, Jane, additional, Abok, Florence, additional, Arinaitwe, Rinah, additional, Birungi, Diana, additional, Mwesigwa, Evans, additional, Atwine, Daniel, additional, Mbega, Hassan, additional, Orikiriza, Patrick, additional, Taremwa, Ivan, additional, Turyashemererwa, Esther, additional, Derrick, Hope, additional, Nyehangane, Dan, additional, Kaitano, Rodney, additional, Logoose, Susan, additional, Businge, Steven, additional, Ntambi, Charles, additional, Mugabi, Jerome, additional, Mzee, John, additional, Besigye, Julius, additional, Kanzira, Saul, additional, Turyatemba, Phionah, additional, Twebaze, Florence, additional, Hambulo, Chimuka, additional, Kapotwe, Vincent, additional, Ngambi, Marjory, additional, Kasakwa, Kunda, additional, Kapula, Chifunda, additional, Zulu, Susan, additional, Nawakwi, Grace, additional, Siasulingana, Teddy, additional, Chilonga, Jessy, additional, Chimbini, Maria, additional, Chilanga, Mutinta, additional, Inambao, Muleya, additional, Mwambazi, Mwate, additional, Halende, Barbra, additional, Mumba, Wyclef, additional, Mankunshe, Endreen, additional, Silavwe, Maureen, additional, Chakopo, Moses, additional, and Moono, Roy, additional

Published
2022
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23. Stillbirths and neonatal mortality in LMICs: A community-based mother-infant cohort study

Author

Rambliere, Lison, de Lauzanne, Agathe, Diouf, Jean-Baptiste, Zo, Andrianirina Zafitsara, Landau, Myriam, Herindrainy, Perlinot, Hivernaud, Delphine, Sarr, Fatoumata Diene, Sok, Touch, Vray, Muriel, Collard, Jean-Marc, Borand, Laurence, Delarocque-Astagneau, Elisabeth, Guillemot, Didier, Kermorvant-Duchemin, Elsa, Huynh, Bich-Tram, Study Group, Birdy, Epidémiologie et modélisation de la résistance aux antimicrobiens - Epidemiology and modelling of bacterial escape to antimicrobials (EMAE), Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP), Centre Hospitalier Roi Baudouin Guédiawaye [Dakar, Senegal], Centre Hospitalier de Soavinandriana (CENHOSOA), Unité d’Épidémiologie et de Recherche clinique [Antananarivo, Madagascar], Institut Pasteur de Madagascar, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Cité (UPCité), Institut Pasteur de Dakar, Ministry of Health [Phnom Penh], Unité de Bactériologie Expérimentale [Antananarivo, Madagascar] (IPM), Johns Hopkins University School of Medicine [Baltimore], Hôpital Raymond Poincaré [Garches], and The present work was supported by internal resources from Paris-Sud University. The BIRDY 1 & 2 research projects were implemented with the financial support of the Monegasque Cooperation for development, the Total Foundation, and MSDAVENIR.

Subjects
[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics
Abstract

International audience; BackgroundThe exact timing, causes, and circumstances of stillbirth and neonatal mortality in low- and middle-income countries (LMICs) remain poorly described, especially for antenatal stillbirths and deaths occurring at home. We aimed to provide reliable estimates of the incidence of stillbirth and neonatal death in three LMICs (Madagascar, Cambodia and Senegal) and to identify their main causes and associated risk factors.MethodsThis study is based on data from an international, multicentric, prospective, longitudinal, community-based mother-infant cohort. We included pregnant mothers and prospectively followed up their children in the community. Stillbirths and deaths were systematically reported; information across healthcare settings was collected and verbal autopsies were performed to document the circumstances and timing of death.ResultsAmong the 4436 pregnancies and 4334 live births, the peripartum period and the first day of life were the key periods of mortality. The estimated incidence of stillbirth was 11 per 1000 total births in Cambodia, 15 per 1000 in Madagascar, and 12 per 1000 in Senegal. We estimated neonatal mortality at 18 per 1000 live births in Cambodia, 24 per 1000 in Madagascar, and 23 per 1000 in Senegal. Based on ultrasound biometric data, 16.1% of infants in Madagascar were born prematurely, where 42% of deliveries and 33% of deaths occurred outside healthcare facilities. Risk factors associated with neonatal death were mainly related to delivery or to events that newborns faced during the first week of life.ConclusionsThese findings underscore the immediate need to improve care for and monitoring of children at birth and during early life to decrease infant mortality. Surveillance of stillbirth and neonatal mortality and their causes should be improved to mitigate this burden in LMICs.

Published
2023

24. Vaccination Coverage and Risk Factors Associated With Incomplete Vaccination Among Children in Cambodia, Madagascar, and Senegal

Author

Verrier, Florian, de Lauzanne, Agathe, Diouf, Jean-Baptiste Niokhhor, Zo, Andrianirina Zafitsara, Ramblière, Lison, Herindrainy, Perlinot, Sarr, Fatoumata Diene, Sok, Touch, Vray, Muriel, Collard, Jean-Marc, Borand, Laurence, Kermorvant-Duchemin, Elsa, Delarocque-Astagneau, Elisabeth, Guillemot, Didier, Huynh, Bich-Tram, Study Group, Bacterial Infections And Antibiotic-Resistant Diseases Among Young Children In Low-Income Countries, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Epidémiologie et modélisation de la résistance aux antimicrobiens - Epidemiology and modelling of bacterial escape to antimicrobials (EMAE), Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP), Centre Hospitalier Roi Baudouin Guédiawaye [Dakar, Senegal], Centre Hospitalier de Soavinandriana (CENHOSOA), Institut Pasteur de Madagascar, Institut Pasteur de Dakar, Ministry of Health [Phnom Penh], Johns Hopkins University School of Medicine [Baltimore], CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Cité (UPCité), Hôpital Raymond Poincaré [Garches], Université Paris-Saclay, AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), This work was supported by the Department of International Cooperation of the Principality of Monaco, MSD Avenir, and Total Foundation., and BIRDY Study Group. Members from the Institut Pasteur in Madagascar include Aina Nirina Randriamamonjiarison, Tanjona Antsa Volahasina, Fanjalalaina Rasoanaivo, Feno Manitra Jacob Rakotoarimanana, Tanjona Bodonirina Raheliarivao, and Frédérique Randrianirina. Members from the Institut Pasteur in Cambodia include Thida Chon, Sophie Goyet, Alexandra Kerleguer, Véronique Ngo, Siyin Lach, Pring Long, and Arnaud Tarantola. Members from the Institut Pasteur in Senegal include Marguerite Diatta, Joseph Faye, and Abdoulaye Seck. Members from the Institut Pasteur in Paris include Michael Padget, Armiya Youssouf Abdou, and Benoit Garin.

Subjects
Infectious Diseases, Oncology, Madagascar, risk factors, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, vaccine coverage, Cambodia, Senegal
Abstract

Background Vaccination reduces mortality from infectious disease, which is the leading cause of death in children under 5 and bears a particularly high burden in low- and middle-income countries. The Global Vaccine Action Plan (2011–2020) has set a target of 90% vaccine coverage for all vaccines included in national immunization programs by 2020. The objectives of this study were to estimate vaccine coverage among children in Madagascar, Cambodia, and Senegal and to identify the risk factors associated with incomplete vaccination. Methods Using data from a community-based prospective cohort that included all newborn of some areas from 2012 to 2018 in these 3 countries, vaccine coverage was estimated for BCG, hepatitis B, oral polio, pentavalent (targeting diphtheria, tetanus, pertussis, hepatitis B, and Haemophilus influenzae type b), and measles vaccines. Risk factor analysis was performed with logistic regression models to identify correlates of incomplete vaccination. Results A total of 3606 children were followed up, and vaccine coverage was below the 90% threshold for most vaccines in all countries. Coverage was higher for vaccines recommended at birth and at 6 weeks, while a decrease in coverage for subsequent doses was observed for vaccines requiring several doses (23–47 points). Low birth weight ( Conclusions Vaccine coverage for common childhood vaccines was lower than World Health Organization recommendations, and multidisciplinary approaches may help to improve vaccine coverage and timeliness.

Published
2023

25. Acceptability of decentralizing childhood tuberculosis diagnosis in low-income countries with high tuberculosis incidence: experiences and perceptions from health care workers in sub-Saharan Africa and South-East Asia

Author

Joshi, Basant, primary, De Lima, Yara Voss, additional, Massom, Douglas Mbang, additional, Kaing, Sanary, additional, Banga, Marie-France, additional, Kamara, Egerton Tamba, additional, Sesay, Sheriff, additional, Borand, Laurence, additional, Taguebue, Jean-Voisin, additional, Moh, Raoul, additional, Khosa, Celso, additional, Breton, Guillaume, additional, Mwanga-Amumpaire, Juliet, additional, Bonnet, Maryline, additional, Wobudeya, Eric, additional, Marcy, Olivier, additional, and Orne-Gliemann, Joanna, additional

Published
2023
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26. Simplified Criteria to Assess Long-Term Antiviral Treatment Indication in Chronic HBV Infected Pregnant Women in Cambodia: A Call for Simplification and Standardization

Author

Yang, Jee-Seon, primary, Sovann, Saren, additional, Shimakawa, Yusuke, additional, Nhoueng, Sovann, additional, Dim, Bunnet, additional, Vong, Chanlina, additional, Sann, Channa, additional, Guillebaud, Julia, additional, Vann, Darapolin, additional, Touch, Bunrith, additional, Chea, Hyna, additional, Phirum, Wathanak Pisey Choupoan, additional, Rosenthal, Eric, additional, Paul, Christelle, additional, Khun, Leangchhun, additional, Yay, Chantana, additional, Laurent, Denis, additional, Chhun, Samsorphea, additional, Borand, Laurence, additional, and Ségéral, Olivier, additional

Published
2023
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27. Effect of Decentralizing Childhood Tuberculosis Diagnosis to Primary Health Center and District Hospital Level - a Pre-Post Study in Six High Tuberculosis Incidence Countries

Author

Wobudeya, Eric, primary, Nanfuka, Mastula, additional, Nguyet, Minh Huyen Ton Nu, additional, Taguebue, Jean-Voisin, additional, Moh, Raoul, additional, Breton, Guillaume, additional, Khosa, Celso, additional, Borand, Laurence, additional, Mwanga-Amumpaire, Juliet, additional, Mustapha, Ayeshatu, additional, Nolna, Sylvie Kwedi, additional, Komena, Eric Auguste, additional, Mugisha, Jacob Ross, additional, Natukunda, Naome, additional, Dim, Bunnet, additional, De Lauzanne, Agathe, additional, Cumbe, Saniata, additional, Balestre, Eric, additional, Poublan, Julien, additional, Lounnas, Manon, additional, Ngu, Eden, additional, Joshi, Basant, additional, Norval, Pierre-Yves, additional, Terquiem, Etienne Leroy, additional, Turyahabwe, Stavia, additional, Foray, Lynda, additional, Sidibé, Souleymane, additional, Mbassa, Vincent, additional, Manhiça, Ivan, additional, Sekadde, Moorine, additional, Detjen, Anne, additional, Verkuijl, Sabine, additional, Mao, Tan Eang, additional, Orne-Gliemann, Joanna, additional, Bonnet, Maryline, additional, Marcy, Olivier, additional, and Group, TBSpeed Decentralization Study, additional

Published
2023
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28. Causes and Determinants of Mortality in HIV-Infected Adults With Tuberculosis: An Analysis From the CAMELIA ANRS 1295-CIPRA KH001 Randomized Trial

Author

CAMELIA (ANRS 1295-CIPRA KH001) Study Team, Marcy, Olivier, Laureillard, Didier, Madec, Yoann, Chan, Sarin, Mayaud, Charles, Borand, Laurence, Prak, Narom, Kim, Chindamony, Lak, Kim Khemarin, Hak, Chanroeurn, Dim, Bunnet, Sok, Thim, Delfraissy, Jean-François, Goldfeld, Anne E., and Blanc, François-Xavier

Published
2014
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30. High Performance of Systematic Combined Urine Liboarabinomannan Test and Sputum Xpert MTB/RIF for Tuberculosis Screening in Severely Immunosuppressed Ambulatory Adults With Human Immunodeficiency Virus.

Author

Bonnet, Maryline, Gabillard, Delphine, Domoua, Serge, Muzoora, Conrad, Messou, Eugène, Sovannarith, Samreth, Nguyen, Duc Bang, Badje, Anani, Juchet, Sylvain, Bunnet, Dim, Borand, Laurence, Natukunda, Naome, Tran, Thị Hong, Anglaret, Xavier, Laureillard, Didier, and Blanc, François-Xavier

Subjects
TUBERCULOSIS diagnosis, SPUTUM microbiology, LIPOPOLYSACCHARIDES, HIV-positive persons, CHEST X rays, IMMUNOCOMPROMISED patients, MEDICAL screening, IMMUNOSUPPRESSION, RAPID diagnostic tests, ANTIRETROVIRAL agents, CD4 lymphocyte count, DESCRIPTIVE statistics, WALKING, RESEARCH funding, DIAGNOSTIC errors, SECONDARY analysis
Abstract

Background In people with human immunodeficiency virus (PWH), the World Health Organization–recommended tuberculosis (TB) 4-symptom screen (W4SS) targeting those who need molecular rapid testing may be suboptimal. We assessed the performance of different TB screening approaches in severely immunosuppressed PWH enrolled in the guided-treatment group of the STATIS trial (NCT02057796). Methods Ambulatory PWH with no overt evidence of TB and CD4 count <100 cells/µL were screened for TB prior to antiretroviral therapy (ART) initiation with W4SS, chest radiograph (CXR), urine lipoarabinomannan (LAM) test, and sputum Xpert MTB/RIF (Xpert). Correctly and wrongly identified cases by screening approaches were assessed overall and by CD4 count threshold (≤50 and 51–99 cells/µL). Results Of 525 enrolled participants (median CD4 count, 28 cells/µL), 48 (9.9%) were diagnosed with TB at enrollment. Among participants with a negative W4SS, 16% had either a positive Xpert, a CXR suggestive of TB, or a positive urine LAM test. The combination of sputum Xpert and urine LAM test was associated with the highest proportion of participants correctly identified as TB (95.8%) and non-TB cases (95.4%), with proportions equally high among participants with CD4 counts above or below 50 cells/µL. Restricting the use of sputum Xpert, urine LAM test, or CXR to participants with a positive W4SS reduced the proportion of wrongly and correctly identified cases. Conclusions There is a clear benefit to perform both sputum Xpert and urine LAM tests as TB screening in all severely immunosuppressed PWH prior to ART initiation, not only in those with a positive W4SS. Clinical Trials Registration. NCT02057796. [ABSTRACT FROM AUTHOR]

Published
2023
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32. A community survey of antibiotic consumption among children in Madagascar and Senegal: the importance of healthcare access and care quality

Author

Padget, Michael, Tamarelle, Jeanne, Herindrainy, Perlinot, Ndir, Awa, Diene Sarr, Fatoumata, Richard, Vincent, Piola, Patrice, Guillemot, Didier, Delarocque-Astagneau, Elisabeth, Seguy, Maud, Cherblanc, Fanny, Watier, Laurence, Nadimpalli, Maya, Le Fouler, Lenaig, Garin, Benoit, Huynh, Bich-Tram, Collard, Jean-Marc, Raheliarivao, Bodonirina Tanjona, Rakotoarimanana, Feno Manitra Jacob, Randrianirina, Frédérique, Vray, Muriel, Seck, Abdoulaye, Bercion, Raymond, Sow, Amy Gassama, Diouf, Jean Baptiste, Dieye, Pape Samba, Sy, Balla, Ndao, Bouya, Borand, Laurence, Chon, Thida, de Lauzanne, Agathe, Goyet, Sophie, Kerleguer, Alexandra, Lach, Siyin, Ngo, Veronique, Tarantola, Arnaud, Touch, Sok, and Kermorvant-Duchemin, Elsa

Published
2017
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34. Excess risk of subsequent infection in hospitalized children from a community cohort study in Cambodia and Madagascar

Author

Rambliere, Lison, primary, Kermorvant-Duchemin, Elsa, additional, de Lauzanne, Agathe, additional, Collard, Jean-Marc, additional, Herindrainy, Perlinot, additional, Vray, Muriel, additional, Garin, Benoit, additional, Zo, Andrianirina Zafitsara, additional, Rasoanaivo, Fanjalalaina, additional, Rakotoarimanana Feno Manitra, Jacob, additional, Raheliarivao, Tanjona Bodonirina, additional, Diouf, Jean-Baptiste Niokhhor, additional, Ngo, Véronique, additional, Lach, Siyin, additional, Long, Pring, additional, Borand, Laurence, additional, Sok, Touch, additional, Abdou, Armiya Youssouf, additional, Padget, Michael, additional, Madec, Yoann, additional, Guillemot, Didier, additional, Delarocque-Astagneau, Elisabeth, additional, and Huynh, Bich-Tram, additional

Published
2022
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35. Impact of Systematic Tuberculosis Detection on Mortality in Young Children with Severe Pneumonia in High Tuberculosis Incidence Countries – A Stepped Wedge Cluster Randomized Trial

Author

Marcy, Olivier, primary, Font, Hélène, additional, Vessière, Aurelia, additional, Borand, Laurence, additional, Chabala, Chishala, additional, Khosa, Celso, additional, Taguebue, Jean-Voisin, additional, Moh, Raoul, additional, Mwanga-Amumpaire, Juliet, additional, Lounnas, Mannon, additional, Mulenga, Veronica, additional, Mavale, Sandra, additional, Chilundo, Josina, additional, Rego, Dalila, additional, Nduna, Bwendo, additional, Shankalala, Perfect, additional, Chirwa, Uzima, additional, De Lauzanne, Agathe, additional, Dim, Bunnet, additional, Tiogouo Ngouana, Emeline, additional, Folquet Amorrissany, Madeleine, additional, Cisse, Lassina, additional, Amon Tanoh Dick, Flore, additional, Komena, Eric Auguste, additional, Kwedi Nolna, Sylvie, additional, Businge, Gerald, additional, Natukunda, Naome, additional, Cumbe, Saniata, additional, Mbekeka, Prossy, additional, Kim, Ang, additional, Keang, Chanrithea, additional, Pol, Sokha, additional, Maleche-Obimbo, Elizabeth, additional, Seddon, James, additional, Mao, Tan Eang, additional, Graham, Stephen M., additional, Delacourt, Christophe, additional, Wobudeya, Eric, additional, Bonnet, Maryline, additional, and Group, TB-Speed Pneumonia Study, additional

Published
2022
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36. Tuberculosis Diagnosis in HIV-Infected Children: Comparison of the 2012 and 2015 Clinical Case Definitions for Classification of Intrathoracic Tuberculosis Disease

Author

Marcy, Olivier, primary, Goyet, Sophie, additional, Borand, Laurence, additional, Msellati, Philippe, additional, Ung, Vibol, additional, Tejiokem, Mathurin, additional, Do Chau, Giang, additional, Ateba-Ndongo, Francis, additional, Ouedraogo, Abdoul Salam, additional, Dim, Bunnet, additional, Perez, Paul, additional, Asselineau, Julien, additional, Carcelain, Guislaine, additional, Blanche, Stéphane, additional, Delacourt, Christophe, additional, and Godreuil, Sylvain, additional

Published
2021
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37. In-field Evaluation of SD Bioline HBsAg Whole Blood Rapid Test in Pregnant Women in Cambodia: the ANRS 12345 TA PROHM Study

Author

Segeral, Olivier, primary, Phirum, Wathanakpiseychoupoan, additional, Khan, Ousa, additional, Chea, Hyna, additional, Sovann, Saren, additional, Nhoeung, Sovann, additional, Chhim, Kearena, additional, Yin, Song, additional, Dim, Bunnet, additional, Yay, Chantana, additional, Laurent, Denis, additional, Chhun, Samsorphea, additional, and Borand, Laurence, additional

Published
2021
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40. Leakiness at the human-animal interface in Southeast Asia and implications for the spread of antibiotic resistance

Author

Nadimpalli, Maya L., primary, Stegger, Marc, additional, Viau, Roberto, additional, Yith, Vuthy, additional, de Lauzanne, Agathe, additional, Sem, Nita, additional, Borand, Laurence, additional, Huynh, Bich-tram, additional, Brisse, Sylvain, additional, Passet, Virginie, additional, Overballe-Petersen, Søren, additional, Aziz, Maliha, additional, Gouali, Malika, additional, Jacobs, Jan, additional, Phe, Thong, additional, Hungate, Bruce A., additional, Leshyk, Victor O., additional, Pickering, Amy J., additional, Gravey, François, additional, Liu, Cindy M., additional, Johnson, Timothy J., additional, Hello, Simon Le, additional, and Price, Lance B., additional

Published
2021
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41. FRI-146 - Evaluation of hepatitis B core-related antigen rapid test (HBcrAg-RDT) to identify HBV-infected women eligible for peripartum antiviral prophylaxis in resource-limited countries

Author

Vincent, Jeanne Perpétue, Segeral, Olivier, Kone, Amariane, Borand, Laurence, Adoukara, Jean-Pierre, Kania, Dramane, Tiendrebeogo, Abdoul, Pivert, Adeline, Sovan, Saren, Yang, Jee-Seon, Delvallez, Gauthier, Fabiani, Françoise Lunel, Tanaka, Yasuhito, and Shimakawa, Yusuke

Published
2023
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42. Excess Risk of Subsequent Infection in Hospitalized Children: Evidence from a Community Cohort Study in Cambodia and Madagascar

Author

Rambliere, Lison, primary, Kermorvant-Duchemin, Elsa, additional, De Lauzanne, Agathe, additional, Collard, Jean-Marc, additional, Herindrainy, Perlinot, additional, Vray, Muriel, additional, Garin, Benoit, additional, Zo, Andrianirina Zafitsara, additional, Rasoanaivo, Fanjalalaina, additional, Rakotoarimanana, Feno Manitra Jacob, additional, Raheliarivao, Tanjona Bodonirina, additional, Diouf, Jean Baptiste Niokhhor, additional, Ngo, Véronique, additional, Lach, Siyin, additional, Long, Pring, additional, Borand, Laurence, additional, Sok, Touch, additional, Abdou, Armiya Youssouf, additional, Padget, Michael, additional, Madec, Yoann, additional, Guillemot, Didier, additional, Delarocque-Astagneau, Elisabeth, additional, and Huynh, Bich-Tram, additional

Published
2021
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44. Tuberculosis Diagnosis in HIV-Infected Children: Comparison of the 2012 and 2015 Clinical Case Definitions for Classification of Intrathoracic Tuberculosis Disease.

Author

Marcy, Olivier, Goyet, Sophie, Borand, Laurence, Msellati, Philippe, Ung, Vibol, Tejiokem, Mathurin, Chau, Giang Do, Ateba-Ndongo, Francis, Ouedraogo, Abdoul Salam, Dim, Bunnet, Perez, Paul, Asselineau, Julien, Carcelain, Guislaine, Blanche, Stéphane, Delacourt, Christophe, and Godreuil, Sylvain

Subjects
TUBERCULOSIS diagnosis, HIV-positive persons, CHEST diseases, STATISTICS, REFERENCE values, CONFIDENCE intervals, COMPARATIVE studies, CHILDREN
Abstract

Background There is no gold standard for tuberculosis diagnosis in children. Clinical Case Definitions for Classification of Intrathoracic Tuberculosis in Children were proposed by international experts in 2012 and updated in 2015. We aimed to compare the 2012 and 2015 Clinical Case Definitions in HIV-infected children with suspected tuberculosis. Methods We enrolled HIV-infected children with suspected tuberculosis in Burkina Faso, Cambodia, Cameroon, and Vietnam (ANRS [Agence Nationale de Recherches sur le SIDA et les hépatites virales] 12229 PAANTHER [Pediatric Asian African Network for Tuberculosis and HIV Research] 01 Study). We classified children using the 2012 and 2015 Case Definitions considering as tuberculosis cases those with confirmed tuberculosis and those with probable and unconfirmed tuberculosis in the 2012 and the 2015 classifications, respectively. We assessed agreement between both classifications. Results Of 438 children enrolled, 197 (45.0%) children were classified as tuberculosis (45 confirmed, 152 probable) using the 2012 Case Definition and 251 (57.3%) were classified as tuberculosis (55 confirmed, 196 unconfirmed) using the 2015 classification. Inter-classification agreement for tuberculosis diagnosis was 364/438, 83.1%, with a kappa statistic of 0.667 (95% confidence interval 0.598-0.736). Of 152 children with probable tuberculosis (2012), 142 (93.4%) were considered as tuberculosis by the 2015 version and 10 (6.6%) as unlikely tuberculosis including 9 with spontaneous clinical improvement. Of 132 possible tuberculosis (2012), 58 (43.9%) were reclassified as tuberculosis (2015). Conclusions Agreement between the 2 versions of the Case Definition was substantial but more children were considered as tuberculosis using the 2015 version. Spontaneous symptom resolution reinforces both confidence in the "unlikely" category as being children without tuberculosis and the importance of the clinician's treatment decision in the study. [ABSTRACT FROM AUTHOR]

Published
2022
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45. Earlier versus Later Start of Antiretroviral Therapy in HIV-Infected Adults with Tuberculosis

Author

Blanc, François-Xavier, Sok, Thim, Laureillard, Didier, Borand, Laurence, Rekacewicz, Claire, Nerrienet, Eric, Madec, Yoann, Marcy, Olivier, Chan, Sarin, Prak, Narom, Kim, Chindamony, Lak, Khemarin Kim, Hak, Chanroeurn, Dim, Bunnet, Sin, Chhun Im, Sun, Sath, Guillard, Bertrand, Sar, Borann, Vong, Sirenda, Fernandez, Marcelo, Fox, Lawrence, Delfraissy, Jean-François, and Goldfeld, Anne E.

Published
2011
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46. Systematic or Test-Guided Treatment for Tuberculosis in HIV-Infected Adults

Author

Blanc, François-Xavier, primary, Badje, Anani D., additional, Bonnet, Maryline, additional, Gabillard, Delphine, additional, Messou, Eugène, additional, Muzoora, Conrad, additional, Samreth, Sovannarith, additional, Nguyen, Bang D., additional, Borand, Laurence, additional, Domergue, Anaïs, additional, Rapoud, Delphine, additional, Natukunda, Naome, additional, Thai, Sopheak, additional, Juchet, Sylvain, additional, Eholié, Serge P., additional, Lawn, Stephen D., additional, Domoua, Serge K., additional, Anglaret, Xavier, additional, and Laureillard, Didier, additional

Published
2020
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47. Klebsiella pneumoniae carriage in low-income countries: antimicrobial resistance, genomic diversity and risk factors

Author

Huynh, Bich-Tram, primary, Passet, Virginie, additional, Rakotondrasoa, Andriniaina, additional, Diallo, Thierno, additional, Kerleguer, Alexandra, additional, Hennart, Melanie, additional, Lauzanne, Agathe De, additional, Herindrainy, Perlinot, additional, Seck, Abdoulaye, additional, Bercion, Raymond, additional, Borand, Laurence, additional, Pardos de la Gandara, Maria, additional, Delarocque-Astagneau, Elisabeth, additional, Guillemot, Didier, additional, Vray, Muriel, additional, Garin, Benoit, additional, Collard, Jean-Marc, additional, Rodrigues, Carla, additional, and Brisse, Sylvain, additional

Published
2020
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48. Hepatitis B e Antigen (HBeAg) Rapid Test and Alanine Aminotransferase Level–Based Algorithm to Identify Pregnant Women at Risk of HBV Mother-to-Child Transmission: The ANRS 12345 TA PROHM Study

Author

Segeral, Olivier, primary, Dim, Bunnet, additional, Durier, Christine, additional, Prak, Sophearot, additional, Chhim, Kearena, additional, Vong, Chanlina, additional, Pech, Sothy, additional, Tiv, Say, additional, Nem, Bunthoeun, additional, Hout, Kay, additional, Nouhin, Janin, additional, Chhun, Samsorphea, additional, and Borand, Laurence, additional

Published
2020
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49. Klebsiella pneumoniae related community-acquired acute lower respiratory infections in Cambodia: Clinical characteristics and treatment

Author

Rammaert Blandine, Goyet Sophie, Beauté Julien, Hem Sopheak, Te Vantha, Try Patrich, Mayaud Charles, Borand Laurence, Buchy Philippe, Guillard Bertrand, and Vong Sirenda

Subjects
Klebsiella pneumoniae, Community-acquired, Pneumonia, Extended-spectrum betalactamases, Diabetes mellitus, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background In many Asian countries, Klebsiella pneumoniae (KP) is the second pathogen responsible for community-acquired pneumonia. Yet, very little is known about KP etiology in ALRI in Cambodia, a country that has one of the weakest medical infrastructures in the region. We present here the first clinico-radiological description of KP community-acquired ALRI in hospitalized Cambodian patients. Methods Through ALRI surveillance in two provincial hospitals, KP was isolated from sputum and blood cultures, and identified by API20E gallery from patients ≥ 5 years-old with fever and respiratory symptoms onset ≤14 days. Antibiotics susceptibility testing was provided systematically to clinicians when bacteria were isolated. We collected patients' clinical, radiological and microbiological data and their outcome 3 months after discharge. We also compared KP-related with other bacteria-related ALRI to determine risk factors for KP infection. Results From April 2007 to December 2009, 2315 ALRI patients ≥ 5 years-old were enrolled including 587 whose bacterial etiology could be assigned. Of these, 47 (8.0%) had KP infection; their median age was 55 years and 68.1% were females. Reported prior medication was high (42.5%). Patients' chest radiographs showed pneumonia (61.3% including 39% that were necrotizing), preexisting parenchyma lesions (29.5%) and pleural effusions alone (4.5%) and normal parenchyma (4.5%). Five patients had severe conditions on admission and one patient died during hospitalization. Of the 39 patients that were hospital discharged, 14 died including 12 within 1 month after discharge. Only 13 patients (28%) received an appropriate antibiotherapy. Extended-spectrum beta-lactamases (ESBL) - producing strains were found in 8 (17.0%) patients. Female gender (Odds ratio (OR) 2.1; p = 0.04) and diabetes mellitus (OR 3.1; p = 0.03) were independent risk factors for KP-related ALRI. Conclusions KP ALRI in Cambodia has high fatality rate, are more frequently found in women, and should be considered in diabetic patients. The extremely high frequency of ESBL-producing strains in the study is alarming in the context of uncontrolled antibiotic consumption and in absence of microbiology capacity in most public-sector hospitals.

Published
2012
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50. Combating Global Antibiotic Resistance: Emerging One Health Concerns in Lower- and Middle-Income Countries

Author

Nadimpalli, Maya, Delarocque-Astagneau, Elisabeth, Love, David C, Price, Lance B, Huynh, Bich-Tram, Collard, Jean-Marc, Lay, Kruy Sun, Borand, Laurence, Ndir, Awa, Walsh, Timothy R, Guillemot, Didier, De Lauzanne, Agathe, Kerleguer, Alexandra, Tarantola, Arnaud, Piola, Patrice, Chon, Thida, Lach, Siyin, Ngo, Veronique, Touch, Sok, Andrianirina, Zo Zafitsara, Vray, Muriel, Richard, Vincent, Seck, Abdoulaye, Bercion, Raymond, Sow, Amy Gassama, Diouf, Jean Baptiste, Dieye, Pape Samba, Sy, Balla, Ndao, Bouya, Seguy, Maud, Watier, Laurence, Abdou, Armiya Youssouf, Biostatistique, Biomathématique, Pharmacoépidémiologie et Maladies Infectieuses (B2PHI), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Johns Hopkins Bloomberg School of Public Health [Baltimore], Johns Hopkins University (JHU), Pharmacoepidemiologie et évaluation de l'impact des produits de santé sur les populations, Université Bordeaux Segalen - Bordeaux 2-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Unité de Bactériologie Expérimentale [Antananarivo, Madagascar] (IPM), Institut Pasteur de Madagascar, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP), Unité d'Épidémiologie et de Santé Publique [Phnom Penh], Institut Pasteur de Dakar, Université du Québec à Montréal = University of Québec in Montréal (UQAM), Unité d'Epidémiologie [Antananarivo, Madagascar] (IPM), Communicable Disease Department [Phnom Penh] (CDC MOH), Ministry of Health [Mozambique], Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology, Pasteur-Cnam Risques infectieux et émergents (PACRI), Institut Pasteur [Paris]-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Institut Pasteur [Paris]-Conservatoire National des Arts et Métiers [CNAM] (CNAM), Institut Pasteur de Bangui, IDEFI-N-Reflexpro, Fonctionnement, évolution et mécanismes régulateurs des écosystèmes forestiers (ECOTROP), Centre National de la Recherche Scientifique (CNRS)-Muséum national d'Histoire naturelle (MNHN), Bacterial Infections and antibiotic-Resistant Diseases among Young children in low-income countries (BIRDY) Study Group., Tarantola, Arnaud, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), and Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS)

Subjects
0301 basic medicine, Microbiology (medical), Environmental pollution, Drug resistance, 03 medical and health sciences, 0302 clinical medicine, Antibiotic resistance, Drug Misuse, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Development economics, Medicine, Humans, 030212 general & internal medicine, One Health, Developing Countries, Poverty, 2. Zero hunger, business.industry, Middle income countries, Drug Resistance, Microbial, Antibiotic misuse, Food safety, 3. Good health, Anti-Bacterial Agents, 030104 developmental biology, Infectious Diseases, 13. Climate action, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Income, business, Environmental Pollution
Abstract

International audience; Antibiotic misuse in lower- and middle-income countries (LMICs) contributes to the development of antibiotic resistance that can disseminate globally. Strategies specific to LMICs that seek to reduce antibiotic misuse by humans, but simultaneously improve antibiotic access, have been proposed. However, most approaches to date have not considered the growing impact of animal and environmental reservoirs of antibiotic resistance, which threaten to exacerbate the antibiotic resistance crisis in LMICs. In particular, current strategies do not prioritize the impacts of increased antibiotic use for terrestrial food-animal and aquaculture production, inadequate food safety, and widespread environmental pollution. Here, we propose new approaches that address emerging, One Health challenges.

Published
2018

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