207 results on '"Bont LJ"'
Search Results
2. Incidence rates and symptomatology of community infections with SARS-CoV-2 in children and parents: The CoKids longitudinal household study
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de Hoog, MLA, primary, Sluiter-Post, JGC, additional, Westerhof, I, additional, Fourie, E, additional, Heuvelman, VD, additional, Boom, TT, additional, Euser, SM, additional, Badoux, P, additional, Reusken, C, additional, Bont, LJ, additional, Sanders, L, additional, Jaddoe, VWV, additional, Herpers, BL, additional, Eggink, D, additional, Wildenbeest, JG, additional, Duijts, L, additional, van Houten, MA, additional, and Bruijning-Verhagen, PCJL, additional
- Published
- 2021
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3. Gender differences in the use of cardiovascular interventions in HIV‐positive persons; the D:A:D Study
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Hatleberg, Camilla I., Ryom, Lene, El?Sadr, Wafaa, Mocroft, Amanda, Reiss, Peter, De Wit, Stephane, Dabis, Francois, Pradier, Christian, Monforte, Antonella D'Arminio, Kovari, Helen, Law, Matthew, Lundgren, Jens D., Sabin, Caroline A., Calvo, G, Bonnet, F, Kirk, O, Morfeldt, L, Weber, R, Lind?Thomsen, A, Brandt, R Salbøl, Hillebreght, M, Zaheri, S, Wit, Fwnm, Scherrer, A, Schöni?Affolter, F, Rickenbach, M, Tavelli, A, Fanti, I, Leleux, O, Mourali, J, Le Marec, F, Boerg, E, Thulin, E, Sundström, A, Bartsch, G, Thompsen, G, Necsoi, C, Delforge, M, Fontas, E, Caissotti, C, Mateu, S, Torres, F, Petoumenos, K, Blance, A, Huang, R, Puhr, R, Laut, K, Kristensen, D, Phillips, An, Kamara, Da, Smith, Cj, Brandt, Rs, Raben, D, Matthews, C, Bojesen, A, Grevsen, Al, Powderly, B, Shortman, N, Moecklinghoff, C, Reilly, G, Franquet, X, Smit, C, Ross, M, Fux, Ca, Morlat, P, Friis?Møller, N, Kowalska, J, Bohlius, J, Bower, M, Fätkenheuer, G, Grulich, A, Sjøl, A, Meidahl, P, Iversen, Js, Hillebregt, M, Prins, Jm, Kuijpers, Tw, Scherpbier, Hj, Meer, Jtm, Godfried, Mh, Poll, T, Nellen, Fjb, Geerlings, Se, Vugt, M, Pajkrt, D, Bos, Jc, Wiersinga, Wj, Valk, M, Goorhuis, A, Hovius, Jw, Eden, J, Henderiks, A, Hes, Amh, Mutschelknauss, M, Nobel, He, Pijnappel, Fjj, Jurriaans, S, Back, Nkt, Zaaijer, Hl, Berkhout, B, Cornelissen, Mte, Schinkel, Cj, Thomas, Xv, Ziekenhuis, A De Ruyter, Berge, M, Stegeman, A, Baas, S, De Looff, L Hage, Ziekenhuis, C, Pronk, Mjh, Ammerlaan, Hsm, Munnik, E, Tjhie, J, Wegdam, Mca, Deiman, B, Scharnhorst, V, Weijsenfeld, Am, Ende, Me, Gorp, Ecm, Schurink, Cam, Nouwen, Jl, Verbon, A, Rijnders, Bja, Bax, Hi, Feltz, M, Bassant, N, Beek, Jea, Vriesde, M, Zonneveld, Lm, Oude?Lubbers, A, Berg?Cameron, Hj, Bruinsma?Broekman, Fb, Groot, J, Man, M Zeeuw?De, Boucher, Cab, Koopmans, Mpg, Kampen, Jja, Pas, Sd, Driessen, Gja, Rossum, Amc, Knaap, Lc, Flevoziekenhuis, E, Branger, J, Rijkeboer?Mes, A, Schippers, Ef, Ijperen, Jm, Geilings, J, Hut, G, Franck, Pfh, Eeden, A, Brokking, W, Groot, M, Elsenburg, Ljm, Damen, M, Isala, Is, Groeneveld, Php, Bouwhuis, Jw, Berg, Jf, Hulzen, Agw, Bliek, Gl, Bor, Pcj, Bloembergen, P, Wolfhagen, Mjhm, Ruijs, Gjhm, Kroon, Fp, Boer, Mgj, Bauer, Mp, Jolink, H, Vollaard, Am, Dorama, W, Holten, N, Claas, Ecj, Wessels, E, Den Hollander, Jg, Pogany, K, Roukens, A, Kastelijns, M, Smit, Jv, Smit, E, Struik?Kalkman, D, Tearno, C, Bezemer, M, Niekerk, T, Pontesilli, O, Lowe, Sh, Lashof, Aml Oude, Posthouwer, D, Ackens, Rp, Schippers, J, Vergoossen, R, Weijenberg?Maes, B, Loo, Ihm, Havenith, Tra, Leyten, Ems, Gelinck, Lbs, Hartingsveld, A, Meerkerk, C, Wildenbeest, Gs, Mutsaers, Jaem, Jansen, Cl, Mulder, Jw, Vrouenraets, Sme, Lauw, Fn, Broekhuizen, Mc, Paap, H, Vlasblom, Dj, Smits, Phm, Weijer, S, Moussaoui, R El, Bosma, As, Vonderen, Mga, Houte, Dpf, Kampschreur, Lm, Dijkstra, K, Faber, S, Weel, J, Kootstra, Gj, Delsing, Ce, De Plas, M Burg?Van, Heins, H, Lucas, E, Kortmann, W, Twillert¤, G, Stuart, Jwt Cohen, Diederen, Bmw, Pronk, D, Truijen?Oud, Fa, Reijden, Wa, Jansen, R, Brinkman¤, K, Berk, Gel, Blok, Wl, Frissen, Phj, Lettinga, Kd, Schouten, Wem, Veenstra, J, Brouwer, Cj, Geerders, Gf, Hoeksema, K, Kleene, Mj, Meché, Ib, Spelbrink, M, Sulman, H, Toonen, Ajm, Wijnands, S, Kwa, D, Witte, E, Koopmans, Pp, Keuter, M, Ven, Ajam, Hofstede, Hjm, Dofferhoff, Asm, Crevel, R, Albers, M, Bosch, Mew, Grintjes?Huisman, Kjt, Zomer, Bj, Stelma, Ff, Rahamat?Langendoen, J, Burger, D, Richter, C, Gisolf, Eh, Hassing, Rj, Beest, G, Van Bentum, Phm, Langebeek, N, Tiemessen, R, Swanink, Cma, Lelyveld, Sfl, Soetekouw, R, Hulshoff, N, Prijt, Lmm, Swaluw, J, Bermon, N, Herpers, Bl, Veenendaal, D, Verhagen, Dwm, Wijk, M, Brouwer, Ae, Kuipers, M, Santegoets, Rmwj, Ven, B, Marcelis, Jh, Buiting, Agm, Kabel, Pj, Bierman, Wfw, Scholvinck, H, Wilting, Kr, Stienstra, Y, Meulen, Pa, Weerd, Da, Ludwig?Roukema, J, Niesters, Hgm, Riezebos?Brilman, A, Leer?Buter, Cc, Knoester, M, Hoepelman, Aim, Mudrikova, T, Ellerbroek, Pm, Oosterheert, Jj, Arends, Je, Barth, Re, Wassenberg, Mwm, Schadd, Em, Elst?Laurijssen, Dhm, Oers?Hazelzet, Eeb, Vervoort, S, Berkel, M, Schuurman, R, Verduyn?Lunel, F, Wensing, Amj, Peters, Ejg, Agtmael, Ma, Bomers, M, Vocht, J, Heitmuller, M, Laan, Lm, Pettersson, Am, Ang, Cw, Geelen, Spm, Wolfs, Tfw, Bont, Lj, Bezemer, Do, Sighem, Ai, Boender, Ts, Jong, A, Bergsma, D, Hoekstra, P, Lang, A, Grivell, S, Jansen, A, Rademaker, Mj, Raethke, M, Meijering, R, Schnörr, S, Groot, L, Akker, M, Bakker, Y, Claessen, E, Berkaoui, A El, Koops, J, Kruijne, E, Lodewijk, C, Munjishvili, L, Peeck, B, Ree, C, Regtop, R, Ruijs, Y, Rutkens, T, Sande, L, Schoorl, M, Timmerman, A, Tuijn, E, Veenenberg, L, Vliet, S, Wisse, A, Woudstra, T, Tuk, B, Dupon, M, Gaborieau, V, Lacoste, D, Malvy, D, Mercié, P, Neau, D, Pellegrin, Jl, Tchamgoué, S, Lazaro, E, Cazanave, C, Vandenhende, M, Vareil, Mo, Gérard, Y, Blanco, P, Bouchet, S, Breilh, D, Fleury, H, Pellegrin, I, Chêne, G, Thiébaut, R, Wittkop, L, Lawson?Ayayi, S, Gimbert, A, Desjardin, S, Lacaze?Buzy, L, Petrov?Sanchez, V, André, K, Bernard, N, Caubet, O, Caunegre, L, Chossat, I, Courtault, C, Dauchy, Fa, Dondia, D, Duffau, P, Dutronc, H, Farbos, S, Faure, I, Ferrand, H, Gerard, Y, Greib, C, Hessamfar, M, Imbert, Y, Lataste, P, Marie, J, Mechain, M, Monlun, E, Ochoa, A, Pistone, T, Raymond, I, Receveur, Mc, Rispal, P, Sorin, L, Valette, C, Vandenhende, Ma, Viallard, Jf, Wille, H, Wirth, G, Lafon, Me, Trimoulet, P, Bellecave, P, Tumiotto, C, Haramburu, F, Miremeont?Salamé, G, Blaizeau, Mj, Decoin, M, Hannapier, C, Pougetoux, E Lenaud Et A., Delveaux, S, D' Ivernois, C, Diarra, F, Uwamaliya?Nziyumvira, B, Palmer, G, Conte, V, Sapparrart, V, Moore, R, Edwards, S, Hoy, J, Watson, K, Roth, N, Lau, H, Bloch, M, Baker, D, Carr, A, Cooper, D, O'Sullivan, M, Nolan, D, Guelfi, G, Domingo, P, Sambeat, Ma, Gatell, J, Del Cacho, E, Cadafalch, J, Fuster, M, Codina, C, Sirera, G, Vaqué, A, Clumeck, N, Gennotte, Af, Gerard, M, Kabeya, K, Konopnicki, D, Libois, A, Martin, C, Payen, Mc, Semaille, P, Laethem, Y, Neaton, J, Krum, E, Thompson, G, Luskin?Hawk, R, Telzak, E, Abrams, Di, Cohn, D, Markowitz, N, Arduino, R, Mushatt, D, Friedland, G, Perez, G, Tedaldi, E, Fisher, E, Gordin, F, Crane, Lr, Sampson, J, Baxter, J, Gazzard, B, Horban, A, Karpov, I, Losso, M, Pedersen, C, Ristola, M, Phillips, A, Rockstroh, J, Peters, L, Fischer, Ah, Laut, K Grønborg, Larsen, Jf, Podlekareva, D, Cozzi?Lepri, A, Shepherd, L, Schultze, A, Amele, S, Kundro, M, Schmied, B, Vassilenko, A, Mitsura, Vm, Paduto, D, Florence, E, Vandekerckhove, L, Hadziosmanovic, V, Begovac, J, Machala, L, Jilich, D, Kronborg, G, Benfield, T, Gerstoft, J, Katzenstein, T, Møller, Nf, Ostergaard, L, Wiese, L, Nielsen, Ln, Zilmer, K, Aho, I, Viard, J?P, Girard, P?M, Duvivier, C, Degen, O, Stellbrink, Hj, Stefan, C, Bogner, J, Chkhartishvili, N, Gargalianos, P, Szlávik, J, Gottfredsson, M, Mulcahy, F, Yust, I, Turner, D, Burke, M, Shahar, E, Hassoun, G, Elinav, H, Haouzi, M, Elbirt, D, Sthoeger, Zm, Esposito, R, Mazeu, I, Mussini, C, Mazzotta, F, Gabbuti, A, Vullo, V, Lichtner, M, Zaccarelli, M, Antinori, A, Acinapura, R, Plazzi, M, Lazzarin, A, Castagna, A, Gianotti, N, Galli, M, Ridolfo, A, Rozentale, B, Uzdaviniene, V, Staub, T, Ormaasen, V, Maeland, A, Bruun, J, Knysz, B, Gasiorowski, J, Inglot, M, Bakowska, E, Flisiak, R, Grzeszczuk, A, Parczewski, M, Maciejewska, K, Aksak?Was, B, Beniowski, M, Mularska, E, Smiatacz, T, Gensing, M, Jablonowska, E, Malolepsza, E, Wojcik, K, Mozer?Lisewska, I, Caldeira, L, Radoi, R, Panteleev, A, Yakovlev, A, Trofimora, T, Khromova, I, Kuzovatova, E, Borodulina, E, Vdoushkina, E, Jevtovic, D, Tomazic, J, Gatell, Jm, Miró, Jm, Moreno, S, Rodriguez, Jm, Clotet, B, Jou, A, Paredes, R, Tural, C, Puig, J, Bravo, I, Gutierrez, M, Mateo, G, Laporte, Jm, Falconer, K, Thalme, A, Sonnerborg, A, Blaxhult, A, Flamholc, L, Cavassini, M, Calmy, A, Furrer, H, Schmid, P, Kuznetsova, A, Kyselyova, G, Sluzhynska, M, Johnson, Am, Simons, E, Johnson, Ma, Orkin, C, Weber, J, Scullard, G, Clarke, A, Leen, C, Thulin, G, Åkerlund, B, Koppel, K, Karlsson, A, Håkangård, C, Castelli, F, Cauda, R, Di Perri, G, Iardino, R, Ippolito, G, Marchetti, Gc, Perno, Cf, Schloesser, F, Viale, P, Ceccherini?Silberstein, F, Girardi, E, Lo Caputo, S, Puoti, M, Andreoni, M, Ammassari, A, Balotta, C, Bandera, A, Bonfanti, P, Bonora, S, Borderi, M, Calcagno, A, Calza, L, Capobianchi, Mr, Cingolani, A, Cinque, P, De Luca, A, Di Biagio, A, Gori, A, Guaraldi, G, Lapadula, G, Madeddu, G, Maggiolo, F, Marchetti, G, Marcotullio, S, Monno, L, Nozza, S, Roldan, E Quiros, Rossotti, R, Rusconi, S, Santoro, Mm, Saracino, A, Galli, L, Lorenzini, P, Rodano, A, Shanyinde, M, Carletti, F, Carrara, S, Di Caro, A, Graziano, S, Petrone, F, Prota, G, Quartu, S, Truffa, S, Giacometti, A, Costantini, A, Barocci, V, Angarano, G, Santoro, C, Suardi, C, Donati, V, Verucchi, G, Minardi, C, Quirino, T, Abeli, C, Manconi, Pe, Piano, P, Cacopardo, B, Celesia, B, Vecchiet, J, Falasca, K, Pan, A, Lorenzotti, S, Sighinolfi, L, Segala, D, Vichi, F, Cassola, G, Viscoli, C, Alessandrini, A, Bobbio, N, Mazzarello, G, Mastroianni, C, Belvisi, V, Caramma, I, Chiodera, A, Milini, P, Rizzardini, G, Moioli, Mc, Piolini, R, Ridolfo, Al, Salpietro, S, Tincati, C, Puzzolante, C, Abrescia, N, Chirianni, A, Borgia, G, Orlando, R, Bonadies, G, Di Martino, F, Gentile, I, Maddaloni, L, Cattelan, Am, Marinello, S, Cascio, A, Colomba, C, Baldelli, F, Schiaroli, E, Parruti, G, Sozio, F, Magnani, G, Ursitti, Ma, Cristaudo, A, Baldin, G, Capozzi, M, Cicalini, S, Sulekova, L Fontanelli, Iaiani, G, Latini, A, Mastrorosa, I, Plazzi, Mm, Savinelli, S, Vergori, A, Cecchetto, M, Viviani, F, Bagella, P, Rossetti, B, Franco, A, Del Vecchio, R Fontana, Francisci, D, Di Giuli, C, Caramello, P, Orofino, Gc, Sciandra, M, Bassetti, M, Londero, A, Pellizzer, G, Manfrin, V, Starnini, G, Ialungo, A, Dollet, K, Dellamonica, P, Bernard, E, Courjon, J, Cua, E, De Salvador?Guillouet, F, Durant, J, Etienne, C, Ferrando, S, Mondain?Miton, V, Naqvi, A, Perbost, I, Pillet, S, Prouvost?Keller, B, Pugliese, P, Rio, V, Risso, K, Roger, Pm, Aubert, V, Battegay, M, Bernasconi, E, Böni, J, Braun, Dl, Bucher, Hc, Ciuffi, A, Dollenmaier, G, Egger, M, Elzi, L, Fehr, J, Fellay, J, Günthard, Hf, Haerry, D, Hasse, B, Hirsch, Hh, Hoffmann, M, Hösli, I, Kahlert, C, Kaiser, L, Keiser, O, Klimkait, T, Kouyos, Rd, Ledergerber, B, Martinetti, G, De Tejada, B Martinez, Marzolini, C, Metzner, Kj, Müller, N, Nicca, D, Pantaleo, G, Paioni, P, Rauch, A, Rudin, C, Scherrer, Au, Speck, R, Stöckle, M, Tarr, P, Trkola, A, Vernazza, P, Wandeler, G, and Yerly, S
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Medical care -- Utilization ,Cardiovascular system -- Surgery ,Sex factors in disease -- Analysis ,HIV patients -- Statistics -- Care and treatment -- Demographic aspects ,Health - Abstract
: Introduction: There is paucity of data related to potential gender differences in the use of interventions to prevent and treat cardiovascular disease (CVD) among HIV‐positive individuals. We investigated whether such differences exist in the observational D:A:D cohort study. Methods: Participants were followed from study enrolment until the earliest of death, six months after last visit or February 1, 2015. Initiation of CVD interventions [lipid‐lowering drugs (LLDs), angiotensin‐converting enzyme inhibitors (ACEIs), anti‐hypertensives, invasive cardiovascular procedures (ICPs) were investigated and Poisson regression models calculated whether rates were lower among women than men, adjusting for potential confounders. Results: Women (n = 12,955) were generally at lower CVD risk than men (n = 36,094). Overall, initiation rates of CVD interventions were lower in women than men; LLDs: incidence rate 1.28 [1.21, 1.35] vs. 2.40 [2.34, 2.46]; ACEIs: 0.88 [0.82, 0.93] vs. 1.43 [1.39, 1.48]; anti‐hypertensives: 1.40 [1.33, 1.47] vs. 1.72 [1.68, 1.77] and ICPs: 0.08 [0.06, 0.10] vs. 0.30 [0.28, 0.32], and this was also true for most CVD interventions when exclusively considering periods of follow‐up for which individuals were at high CVD risk. In fully adjusted models, women were less likely to receive CVD interventions than men (LLDs: relative rate 0.83 [0.78, 0.88]; ACEIs: 0.93 [0.86, 1.01]; ICPs: 0.54 [0.43, 0.68]), except for the receipt of anti‐hypertensives (1.17 [1.10, 1.25]). Conclusion: The use of most CVD interventions was lower among women than men. Interventions are needed to ensure that all HIV‐positive persons, particularly women, are appropriately monitored for CVD and, if required, receive appropriate CVD interventions., Introduction HIV‐positive individuals are known to be at increased risk of cardiovascular disease (CVD) compared to the general population, partly due to an increased prevalence of some CVD risk factors, [...]
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- 2018
- Full Text
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4. Estimated impact of maternal vaccination on global paediatric influenza-related in-hospital mortality: A retrospective case series.
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Löwensteyn, YN, Nair, H, Nunes, MC, van Roessel, I, Vernooij, FS, Willemsen, J, Bont, LJ, Mazur, NI, FLU GOLD study group, Löwensteyn, YN, Nair, H, Nunes, MC, van Roessel, I, Vernooij, FS, Willemsen, J, Bont, LJ, Mazur, NI, and FLU GOLD study group
- Abstract
Background: Influenza virus infection is an important cause of under-five mortality. Maternal vaccination protects children younger than 3 months of age from influenza infection. However, it is unknown to what extent paediatric influenza-related mortality may be prevented by a maternal vaccine since global age-stratified mortality data are lacking. Methods: We invited clinicians and researchers to share clinical and demographic characteristics from children younger than 5 years who died with laboratory-confirmed influenza infection between January 1, 1995 and March 31, 2020. We evaluated the potential impact of maternal vaccination by estimating the number of children younger than 3 months with in-hospital influenza-related death using published global mortality estimates. Findings: We included 314 children from 31 countries. Comorbidities were present in 166 (53%) children and 41 (13%) children were born prematurely. Median age at death was 8·6 (IQR 4·5-16·6), 11·5 (IQR 4·3-24·0), and 15·5 (IQR 7·4-27·0) months for children from low- and lower-middle-income countries (LMICs), upper-middle-income countries (UMICs), and high-income countries (HICs), respectively. The proportion of children younger than 3 months at time of death was 17% in LMICs, 12% in UMICs, and 7% in HICs. We estimated that 3339 annual influenza-related in-hospital deaths occur in the first 3 months of life globally. Interpretation: In our study, less than 20% of children is younger than 3 months at time of influenza-related death. Although maternal influenza vaccination may impact maternal and infant influenza disease burden, additional immunisation strategies are needed to prevent global influenza-related childhood mortality. The missing data, global coverage, and data quality in this study should be taken into consideration for further interpretation of the results. Funding: Bill & Melinda Gates Foundation.
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- 2021
5. Low Sensitivity of BinaxNOW RSV in Infants
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Zuurbier, RP, Bont, LJ, Langedijk, AC, Hamer, M, Korsten, K, Drysdale, SB, Snape, MD, Robinson, H, Pollard, AJ, Martinón-Torres, F, Rodríguez-Tenreiro Sánchez, C, Gómez-Carballa, A, Dacosta-Urbieta, AI, Heikkinen, T, Cunningham, S, van Houten, MA, Wildenbeest, JG, and RESCEU Investigators
- Abstract
BACKGROUND: Respiratory syncytial virus (RSV) is a major cause of hospitalization in infants. Early detection of RSV can optimize clinical management and minimize use of antibiotics. BinaxNOW RSV (BN) is a rapid antigen detection test that is widely used. We aimed to validate the sensitivity of BN in hospitalized and nonhospitalized infants against the gold standard of molecular diagnosis. METHODS: We evaluated the performance of BN in infants with acute respiratory tract infections with different degrees of disease severity. Diagnostic accuracy of BN test results were compared with molecular diagnosis as reference standard. RESULTS: One hundred sixty-two respiratory samples from 148 children from October 2017 to February 2019 were studied. Sixty-six (40.7%) samples tested positive for RSV (30 hospitalizations, 31 medically attended episodes not requiring hospitalization, and 5 nonmedically attended episodes). Five of these samples tested positive with BN, leading to an overall sensitivity of BN of 7.6% (95% confidence interval [CI], 3.3%-16.5%) and a specificity of 100% (95% CI, 96.2%-100%). Sensitivity was low in all subgroups. CONCLUSIONS: We found a low sensitivity of BN for point-of-care detection of RSV infection. BinaxNOW RSV should be used and interpreted with caution.
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- 2020
6. Comparison of Illumina versus Nanopore 16S rRNA Gene Sequencing of the Human Nasal Microbiota
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Heikema, Astrid, A Horst - Kreft, Deborah, Boers, Stefan, Jansen, Rick, Hiltemann, Saskia, de Koning, Willem, Kraaij, Robert, de Ridder, Maria, van Houten, CB, Bont, LJ, Stubbs, Andrew, Hays, John, Heikema, Astrid, A Horst - Kreft, Deborah, Boers, Stefan, Jansen, Rick, Hiltemann, Saskia, de Koning, Willem, Kraaij, Robert, de Ridder, Maria, van Houten, CB, Bont, LJ, Stubbs, Andrew, and Hays, John
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- 2020
7. RSV infection and wheeze in moderate-to-late preterm infants : prediction and cost-effectiveness
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Bont, LJ, Rovers, M.M., Blanken, M.O., Bont, LJ, Rovers, M.M., and Blanken, M.O.
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- 2019
8. Improving diagnosis of bacterial infections : Research without gold standard
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Bont, LJ, Sanders, Elisabeth, van Houten, C.B., Bont, LJ, Sanders, Elisabeth, and van Houten, C.B.
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- 2019
9. Improving diagnosis of bacterial infections: Research without gold standard
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Infectieziekten onderzoek1 (Bont), Child Health, Bont, LJ, Sanders, Lieke, van Houten, C.B., Infectieziekten onderzoek1 (Bont), Child Health, Bont, LJ, Sanders, Lieke, and van Houten, C.B.
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- 2019
10. Antibiotic misuse in respiratory tract infections in children and adultsa prospective, multicentre study (TAILORED Treatment)
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van Houten, CB, Cohen, Abi, Engelhard, D, Hays, John, Karlsson, R, Moore, E, Stubbs, Andrew, Eden, E, Bont, LJ, van Houten, CB, Cohen, Abi, Engelhard, D, Hays, John, Karlsson, R, Moore, E, Stubbs, Andrew, Eden, E, and Bont, LJ
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- 2019
11. Respiratory syncytial virus-related disease burden in young children
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Bont, LJ, van der Ent, Cornelis, Scheltema, N.M., Bont, LJ, van der Ent, Cornelis, and Scheltema, N.M.
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- 2018
12. Informing randomized clinical trials of respiratory syncytial virus vaccination during pregnancy to prevent recurrent childhood wheezing: A sample size analysis
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Riddell, CA, Bhat, N, Bont, LJ, Dupont, WD, Feikin, DR, Fell, DB, Gebretsadik, T, Hartert, TV, Hutcheon, JA, Karron, RA, Nair, H, Reiner, RC, Shi, T, Sly, Peter, Stein, RT, Wu, P, Zar, HJ, Ortiz, JR, Riddell, CA, Bhat, N, Bont, LJ, Dupont, WD, Feikin, DR, Fell, DB, Gebretsadik, T, Hartert, TV, Hutcheon, JA, Karron, RA, Nair, H, Reiner, RC, Shi, T, Sly, Peter, Stein, RT, Wu, P, Zar, HJ, and Ortiz, JR
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- 2018
13. Respiratory syncytial virus-related disease burden in young children
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Child Health, Infectieziekten onderzoek1 (Bont), Bont, LJ, van der Ent, Kors, Scheltema, N.M., Child Health, Infectieziekten onderzoek1 (Bont), Bont, LJ, van der Ent, Kors, and Scheltema, N.M.
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- 2018
14. Observational multi-centre, prospective study to characterize novel pathogen-and host-related factors in hospitalized patients with lower respiratory tract infections and/or sepsis - the 'TAILORED-Treatment' study
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van Houten, CB, Oved, K, Eden, E, Cohen, A, Engelhard, D, Boers, Stefan, Kraaij, Robert, Karlsson, R, Fernandez, D, Gonzalez, E, Li, Yunlei, Stubbs, Andrew, Moore, ERB, Hays, John, Bont, LJ, van Houten, CB, Oved, K, Eden, E, Cohen, A, Engelhard, D, Boers, Stefan, Kraaij, Robert, Karlsson, R, Fernandez, D, Gonzalez, E, Li, Yunlei, Stubbs, Andrew, Moore, ERB, Hays, John, and Bont, LJ
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- 2018
15. Urological care for children with spina bifida : Individual, tailored and without antibiotic prophylaxis
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Bont, LJ, de Jong-de Vos van Steenwijk, Teau, Zegers, S.H.J., Bont, LJ, de Jong-de Vos van Steenwijk, Teau, and Zegers, S.H.J.
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- 2017
16. Immunity to respiratory syncytial virus : a clinical perspective
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Bont, LJ, Faber, T.E., Bont, LJ, and Faber, T.E.
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- 2017
17. Global respiratory syncytial virus-associated mortality in young children (RSV GOLD): a retrospective case series
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Scheltema, NM, Gentile, A, Lucion, F, Nokes, DJ, Munywoki, PK, Madhi, SA, Groome, MJ, Cohen, C, Moyes, J, Thorburn, K, Thamthitiwat, S, Oshitani, H, Lupisan, SP, Gordon, A, Sanchez, JF, O'Brien, KL, Gessner, BD, Sutanto, A, Mejias, A, Ramilo, O, Khuri-Bulos, N, Halasa, N, de-Paris, F, Pires, MR, Spaeder, MC, Paes, BA, Simoes, EAF, Leung, TF, Oliveira, MTDC, Emediato, CCDFL, Bassat, Q, Butt, W, Chi, H, Aamir, UB, Ali, A, Lucero, MG, Fasce, RA, Lopez, O, Rath, BA, Polack, FP, Papenburg, J, Roglic, S, Ito, H, Goka, EA, Grobbee, DE, Nair, H, Bont, LJ, Scheltema, NM, Gentile, A, Lucion, F, Nokes, DJ, Munywoki, PK, Madhi, SA, Groome, MJ, Cohen, C, Moyes, J, Thorburn, K, Thamthitiwat, S, Oshitani, H, Lupisan, SP, Gordon, A, Sanchez, JF, O'Brien, KL, Gessner, BD, Sutanto, A, Mejias, A, Ramilo, O, Khuri-Bulos, N, Halasa, N, de-Paris, F, Pires, MR, Spaeder, MC, Paes, BA, Simoes, EAF, Leung, TF, Oliveira, MTDC, Emediato, CCDFL, Bassat, Q, Butt, W, Chi, H, Aamir, UB, Ali, A, Lucero, MG, Fasce, RA, Lopez, O, Rath, BA, Polack, FP, Papenburg, J, Roglic, S, Ito, H, Goka, EA, Grobbee, DE, Nair, H, and Bont, LJ
- Abstract
BACKGROUND: Respiratory syncytial virus (RSV) infection is an important cause of pneumonia mortality in young children. However, clinical data for fatal RSV infection are scarce. We aimed to identify clinical and socioeconomic characteristics of children aged younger than 5 years with RSV-related mortality using individual patient data. METHODS: In this retrospective case series, we developed an online questionnaire to obtain individual patient data for clinical and socioeconomic characteristics of children aged younger than 5 years who died with community-acquired RSV infection between Jan 1, 1995, and Oct 31, 2015, through leading research groups for child pneumonia identified through a comprehensive literature search and existing research networks. For the literature search, we searched PubMed for articles published up to Feb 3, 2015, using the key terms "RSV", "respiratory syncytial virus", or "respiratory syncytial viral" combined with "mortality", "fatality", "death", "died", "deaths", or "CFR" for articles published in English. We invited researchers and clinicians identified to participate between Nov 1, 2014, and Oct 31, 2015. We calculated descriptive statistics for all variables. FINDINGS: We studied 358 children with RSV-related in-hospital death from 23 countries across the world, with data contributed from 31 research groups. 117 (33%) children were from low-income or lower middle-income countries, 77 (22%) were from upper middle-income countries, and 164 (46%) were from high-income countries. 190 (53%) were male. Data for comorbidities were missing for some children in low-income and middle-income countries. Available data showed that comorbidities were present in at least 33 (28%) children from low-income or lower middle-income countries, 36 (47%) from upper middle-income countries, and 114 (70%) from high-income countries. Median age for RSV-related deaths was 5·0 months (IQR 2·3-11·0) in low-income or lower middle-income countries, 4·0 years (2·0-1
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- 2017
18. Urological care for children with spina bifida: Individual, tailored and without antibiotic prophylaxis
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Infectieziekten onderzoek1 (Bont), Child Health, Infection & Immunity, Bont, LJ, de Jong-de Vos van Steenwijk, Teau, Zegers, S.H.J., Infectieziekten onderzoek1 (Bont), Child Health, Infection & Immunity, Bont, LJ, de Jong-de Vos van Steenwijk, Teau, and Zegers, S.H.J.
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- 2017
19. Immunity to respiratory syncytial virus: a clinical perspective
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Infection & Immunity, Infectieziekten onderzoek1 (Bont), Child Health, Bont, LJ, Faber, T.E., Infection & Immunity, Infectieziekten onderzoek1 (Bont), Child Health, Bont, LJ, and Faber, T.E.
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- 2017
20. Cumulative and current exposure to potentially nephrotoxic antiretrovirals and development of chronic kidney disease in HIV-positive individuals with a normal baseline estimated glomerular filtration rate: a prospective international cohort study
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Steering, D, Powderly, B, Shortman, N, Moecklinghoff, C, Reilly, G, Franquet, X, Ryom, L, Hatleberg, Ci, Sabin, Ca, Kamara, D, Smith, C, Phillips, A, Mocroft, A, Bojesen, A, Grevsen, A, Matthews, C, Raben, D, Lundgren, Jd, Brandt, Rs, Rickenbach, M, Fanti, I, Hillebreght, M, Zaheri, S, Gras, L, Pernot, E, Mourabi, J, Sundström, A, Delforge, M, Fontas, E, Torres, F, Mcmanus, H, Wright, S, Kristensen, D, Sjøl, A, Meidahl, P, Helweg-Larsen, J, Schmidt Iversen, J, Kirk, O, Reiss, P, Smit, C, Ross, M, Fux, Ca, Morlat, P, Moranne, O, Kamara, Da, Weber, R, Pradier, C, Friis-Møller, N, Kowalska, J, Sabin, C, Law, M, d'Arminio Monforte, A, Dabis, F, Bruyand, M, Bonnet, F, Bower, M, Fätkenheuer, G, Donald, A, Grulich, A, Prins, Jm, Kuijpers, Tw, Scherpbier, Hj, van der Meer JT, Wit, Fw, Godfried, Mh, van der Poll, T, Nellen, Fj, Geerlings, Se, van Vugt, M, Pajkrt, D, Bos, Jc, Wiersinga, Wj, van der Valk, M, Goorhuis, A, Hovius, Jw, van Eden, J, Henderiks, A, van Hes AM, Mutschelknauss, M, Nobel, He, Pijnappel, Fj, Westerman, Am, Jurriaans, S, Back, Nk, Zaaijer, Hl, Berkhout, B, Cornelissen, Mt, Schinkel, Cj, Thomas, Xv, De Ruyter Ziekenhuis, A, van den Berge, M, Stegeman, A, Baas, S, de Looff, L, Versteeg, D, Pronk, Mj, Ammerlaan, Hs, Korsten-Vorstermans, Em, de Munnik ES, Jansz, Ar, Tjhie, J, Wegdam, Mc, Deiman, B, Scharnhorst, V, Kinderziekenhuis, E, van der Plas, A, Weijsenfeld, Am, van der Ende ME, de Vries-Sluijs TE, van Gorp EC, Schurink, Ca, Nouwen, Jl, Verbon, A, Rijnders, Bj, Bax, Hi, Hassing, Rj, van der Feltz, M, Bassant, N, van Beek JE, Vriesde, M, van Zonneveld LM, de Oude-Lubbers, A, van den Berg-Cameron HJ, Bruinsma-Broekman, Fb, de Groot, J, de Man de, Z, Broekhoven-Kruijne, Mj, Schutten, M, Osterhaus, Ad, Boucher, Ca, Driessen, Gj, van Rossum AM, van der Knaap LC, Visser, E, Branger, J, Duijf-van de Ven CJ, Haag, D, Schippers, Ef, van Nieuwkoop, C, Brimicombe, Rw, van IJperen, M, van der Hut, G, Franck, Pf, van Eeden, A, Brokking, W, Groot, M, Damen, M, Kwa, Is, Groeneveld, Ph, Bouwhuis, Jw, van den Berg JF, van Hulzen AG, van der Bliek GL, Bor, Pc, Bloembergen, P, Wolfhagen, Mj, Ruijs, Gj, Gasthuis, K, van Lelyveld SF, Soetekouw, R, Hulshoff, N, van der Prijt LM, Schoemaker, M, Bermon, N, van der Reijden WA, Jansen, R, Herpers, Bl, Veenendaal, D, Kroon, Fp, Arend, Sm, de Boer MG, Bauer, Mp, Jolink, H, Vollaard, Am, Dorama, W, Moons, C, Claas, Ec, Kroes, Ac, den Hollander JG, Pogany, K, Kastelijns, M, Smit, Jv, Smit, E, Bezemer, M, van Niekerk, T, Pontesilli, O, Lowe, Sh, Oude Lashof, A, Posthouwer, D, Ackens, Rp, Schippers, J, Vergoossen, R, Weijenberg Maes, B, Savelkoul, Ph, Loo, Ih, Zuiderzee, Mc, Weijer, S, El Moussaoui, R, Heitmuller, M, Kortmann, W, van Twillert, G, Cohen Stuart JW, Diederen, Bm, Pronk, D, van Truijen-Oud FA, van der Reijden, W, Leyten, Em, Gelinck, Lb, van Hartingsveld, A, Meerkerk, C, Wildenbeest, Gs, Mutsaers, Ja, Jansen, Cl, van Vonderen MG, van Houte DP, Dijkstra, K, Faber, S, Weel, J, Kootstra, Gj, Delsing, Ce, van der Burgvan de Plas, M, Heins, H, Lucas, E, Brinkman, K, Frissen, Ph, Blok, Wl, Schouten, We, Bosma, As, Brouwer, Cj, Geerders, Gf, Hoeksema, K, Kleene, Mj, van der Meché IB, Toonen, Aj, Wijnands, S, van Ogtrop ML, Koopmans, Pp, Keuter, M, van der Ven AJ, ter Hofstede HJ, Dofferhoff, As, van Crevel, R, Albers, M, Bosch, Me, Grintjes-Huisman, Kj, Zomer, Bj, Stelma, Ff, Burger, D, Richter, C, van der Berg JP, Gisolf, Eh, Beest, G, van Bentum PH, Langebeek, N, Tiemessen, R, Swanink, Cm, Veenstra, J, Lettinga, Kd, Spelbrink, M, Sulman, H, Witte, E, Peerbooms, Pg, Mulder, Jw, Vrouenraets, Sm, Lauw, Fn, van Broekhuizen MC, Paap, H, Vlasblom, Dj, Oudmaijer Sanders, E, Smits, Ph, Rosingh, Aw, Verhagen, Dw, Geilings, J, van Kasteren ME, Brouwer, Ae, de Kruijf-van de Wiel BA, Kuipers, M, Santegoets, Rm, van der Ven, B, Marcelis, Jh, Buiting, Ag, Kabel, Pj, Bierman, Wf, Sprenger, Hg, Scholvinck, Eh, van Assen, S, Wilting, Kr, Stienstra, Y, de Groot-de Jonge, H, van der Meulen PA, de Weerd DA, Niesters, Hg, Riezebos-Brilman, A, van Leer-Buter CC, Hoepelman, Ai, Schneider, Mm, Mudrikova, T, Ellerbroek, Pm, Oosterheert, Jj, Arends, Je, Barth, Re, Wassenberg, Mw, van Elst-Laurijssen DH, Laan, Lm, van Oers-Hazelzet EE, Patist, J, Vervoort, S, Nieuwenhuis, He, Frauenfelder, R, Schuurman, R, Verduyn-Lunel, F, Wensing, Am, Peters, Ej, van Agtmael MA, Perenboom, Rm, Bomers, M, de Vocht, J, Elsenburg, Lj, Pettersson, Am, Vandenbroucke-Grauls, Cm, Ang, Cw, Geelen, Sp, Wolfs, Tf, Bont, Lj, Nauta, N, Bezemer, Do, van Sighem AI, Hillebregt, M, Kimmel, V, Tong, Y, Lascaris, B, van den Boogaard, R, Hoekstra, P, de Lang, A, Berkhout, M, Grivell, S, Jansen, A, de Groot, L, van den Akker, M, Bergsma, D, Lodewijk, C, Meijering, R, Peeck, B, Raethke, M, Ree, C, Regtop, R, Ruijs, Y, Schoorl, M, Tuijn, E, Veenenberg, L, Woudstra, T, Bakker, Y, de Jong, A, Broekhoven, M, Claessen, E, Rademaker, Mj, Munjishvili, L, Kruijne, E, Tuk, B, Bouchet, S, Breilh, D, Chêne, G, Dupon, M, Fleury, H, Gaborieau, V, Lacoste, D, Malvy, D, Mercié, P, Neau, D, Pellegrin, I, Pellegrin, Jl, Tchamgoué, S, Fagard, C, Lawson-Ayayi, S, Richert, L, Thiébaut, R, Wittkop, L, André, K, Bernard, N, Caunègre, L, Cazanave, C, Ceccaldi, J, Chossat, I, Courtault, C, Dauchy, Fa, De Witte, S, Dondia, D, Dupont, A, Duffau, P, Dutronc, H, Farbos, S, Faure, I, Gerard, Y, Greib, C, Hessamfar-Joseph, M, Imbert, Y, Lataste, P, Lazaro, E, Marie, J, Mechain, M, Meraud, Jp, Monlun, E, Ochoa, A, Pillot-Debelleix, M, Pistone, T, Raymond, I, Receveur, Mc, Rispal, P, Sorin, L, Valette, C, Vandenhende, Ma, Vareil, Mo, Viallard, Jf, Wille, H, Wirth, G, Moreau, Jf, Lafon, Me, Reigadas, S, Trimoulet, P, Haramburu, F, Miremont-Salamé, G, Blaizeau, Mj, Crespel, I, Decoin, M, Delveaux, S, Diarra, F, D'Ivernois, C, Hanappier, C, Leleux, O, Le Marec, F, Lenaud, E, Mourali, J, Pougetoux, A, Uwamaliya-Nziyumvira, B, Tsaranazy, A, Valdes, A, Conte, V, Louis, I, Palmer, G, Sapparrart, V, Touchard, D, Petoumenos, K, Bendall, C, Moore, R, Edwards, S, Hoy, J, Watson, K, Roth, N, Nicholson, J, Bloch, M, Franic, T, Baker, D, Vale, R, Carr, A, Cooper, D, Chuah, J, Ngieng, M, Nolan, D, Skett, J, Calvo, G, Mateu, S, Domingo, P, Sambeat, Ma, Gatell, J, Del Cacho, E, Cadafalch, J, Fuster, M, Codina, C, Sirera, G, Vaqué, A, De Wit, S, Clumeck, N, Necsoi, C, Gennotte, Af, Gerard, M, Kabeya, K, Konopnicki, D, Libois, A, Martin, C, Payen, Mc, Semaille, P, Van, Y, Neaton, J, Bartsch, G, El-Sadr, Wm, Krum, E, Thompson, G, Wentworth, D, Luskin-Hawk, R, Telzak, E, Abrams, Di, Cohn, D, Markowitz, N, Arduino, R, Mushatt, D, Friedland, G, Perez, G, Tedaldi, E, Fisher, E, Gordin, F, Crane, Lr, Sampson, J, Baxter, J, Losso, M, Kundro, M, Vetter, N, Zangerle, R, Karpov, I, Vassilenko, A, Mitsura, Vm, Paduto, D, Florence, E, Vandekerckhove, L, Hadziosmanovic, V, Kostov, K, Begovac, J, Machala, L, Jilich, D, Sedlacek, D, Kronborg, G, Benfield, T, Gerstoft, J, Katzenstein, T, Hansen, Ab, Pedersen, C, Møller, Nf, Ostergaard, L, Dragsted, Ub, Nielsen, Ln, Zilmer, K, Smidt, J, Ristola, M, Aho, I, Katlama, C, Viard, Jp, Girard, Pm, Cotte, L, Duvivier, C, Rockstroh, J, Schmidt, R, van Lunzen, J, Degen, O, Stellbrink, Hj, Stefan, C, Bogner, J, Chkhartishvili, N, Kosmidis, J, Gargalianos, P, Xylomenos, G, Lourida, P, Sambatakou, H, Banhegyi, D, Gottfredsson, M, Mulcahy, F, Yust, I, Turner, D, Burke, M, Shahar, E, Hassoun, G, Elinav, H, Haouzi, M, Sthoeger, Zm, D'Arminio Monforte, A, Esposito, R, Mazeu, I, Mussini, C, Mazzotta, F, Gabbuti, A, Vullo, V, Lichtner, M, Zaccarelli, M, Antinori, A, Acinapura, R, D'Offizi, G, Lazzarin, A, Castagna, A, Gianotti, N, Galli, M, Ridolfo, A, Rozentale, B, Uzdaviniene, V, Matulionyte, R, Staub, T, Hemmer, R, Ormaasen, V, Maeland, A, Bruun, J, Knysz, B, Gasiorowski, J, Inglot, M, Horban, A, Bakowska, E, Grzeszczuk, A, Flisiak, R, Parczewski, M, Pynka, M, Maciejewska, K, Beniowski, M, Mularska, E, Smiatacz, T, Gensing, M, Jablonowska, E, Malolepsza, E, Wojcik, K, Mozer-Lisewska, I, Doroana, M, Caldeira, L, Mansinho, K, Maltez, F, Radoi, R, Oprea, C, Rakhmanova, A, Trofimora, T, Khromova, I, Kuzovatova, E, Jevtovic, D, Shunnar, A, Staneková, D, Tomazic, J, Moreno, S, Rodriguez, J, Clotet, B, Jou, A, Paredes, R, Tural, C, Puig, J, Bravo, I, Gatell, Jm, Miró, Jm, Gutierrez, M, Mateo, G, Laporte, Jm, Blaxhult, A, Flamholc, L, Falconer, K, Thalme, A, Sonnerborg, A, Ledergerber, B, Cavassini, M, Calmy, A, Furrer, H, Battegay, M, Elzi, L, Schmid, P, Kravchenko, E, Chentsova, N, Frolov, V, Kutsyna, G, Baskakov, I, Servitskiy, S, Kuznetsova, A, Kyselyova, G, Gazzard, B, Johnson, Am, Simons, E, Johnson, Ma, Orkin, C, Weber, J, Scullard, G, Fisher, M, Leen, C, Lundgren, J, Grarup, J, Cozzi-Lepri, A, Thiebaut, R, Peters, L, Fischer, Ah, Grønborg Laut, K, Larsen, Jf, Podlekareva, D, Grint, D, Shepherd, L, Schultze, A, Morfeldt, L, Thulin, G, Åkerlund, B, Koppel, K, Karlsson, A, Håkangård, C, Moroni, M, Angarano, G, Armignacco, O, Castelli, F, Cauda, R, Di Perri, G, Iardino, R, Ippolito, G, Perno, Cf, von Schloesser, F, Viale, P, Ceccherini-Silberstein, F, Girardi, E, Lo Caputo, S, Puoti, M, Andreoni, M, Ammassari, A, Balotta, C, Bonfanti, P, Bonora, S, Borderi, M, Capobianchi, R, Cingolani, A, Cinque, P, De Luca, A, Di Biagio, A, Gori, A, Guaraldi, G, Lapadula, G, Madeddu, G, Maggiolo, F, Marchetti, G, Marcotullio, S, Monno, L, Quiros Roldan, E, Rusconi, S, Cicconi, P, Formenti, T, Galli, L, Lorenzini, P, Giacometti, A, Costantini, A, Santoro, C, Suardi, C, Vanino, E, Verucchi, G, Minardi, C, Quirino, T, Abeli, C, Manconi, Pe, Piano, P, Vecchiet, J, Falasca, K, Sighinolfi, L, Segala, D, Cassola, G, Viscoli, G, Alessandrini, A, Piscopo, R, Mazzarello, G, Mastroianni, C, Belvisi, V, Castelli, A, Rizzardini, G, Ridolfo, Al, Piolini, R, Salpietro, S, Carenzi, L, Moioli, Mc, Puzzolante, C, Abrescia, N, Chirianni, A, Guida, Mg, Onofrio, M, Baldelli, F, Francisci, D, Parruti, G, Ursini, T, Magnani, G, Ursitti, Ma, D'Avino, A, Gallo, L, Nicastri, E, Capozzi, M, Libertone, R, Tebano, G, Cattelan, A, Mura, Ms, Caramello, P, Orofino, Gc, Sciandra, M, Pellizzer, G, Manfrin, V, Castelli, Ap, Dollet, K, Caissotti, C, Dellamonica, P, Bernard, E, Cua, E, De Salvador-Guillouet, F, Durant, J, Ferrando, S, Dunais, B, Mondain-Miton, V, Naqvi, A, Perbost, I, Prouvost-Keller, B, Pillet, S, Pugliese, P, Risso, K, Roger, Pm, Aubert, V, Bernasconi, E, Böni, J, Bucher, Hc, Burton-Jeangros, C, Dollenmaier, G, Egger, M, Fehr, J, Fellay, J, Gorgievski, M, Günthard, H, Haerry, D, Hasse, B, Hirsch, Hh, Hoffmann, M, Hösli, I, Kahlert, C, Kaiser, L, Keiser, O, Klimkait, T, Kouyos, R, Kovari, H, Martinetti, G, Martinez de Tejada, B, Metzner, K, Müller, N, Nadal, D, Nicca, D, Pantaleo, G, Rauch, A, Regenass, S, Rudin, C, Schöni-Affolter, F, Schüpbach, J, Speck, R, Tarr, P, Telenti, A, Trkola, A, Vernazza, P, Yerly, S., University College of London [London] (UCL), Rigshospitalet [Copenhagen], Copenhagen University Hospital, Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Aide à la Décision pour une Médecine Personnalisé - Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - EA 2415 (AIDMP), Université Montpellier 1 (UM1)-Université de Montpellier (UM), Epidémiologie et Biostatistique [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Bordeaux [Bordeaux], Chemical Biology, Internal Medicine, Medical Microbiology & Infectious Diseases, Pediatrics, Virology, Mocroft, A:, Lundgren, Jd, Ross, M, Fux, Ca, Reiss, P, Moranne, O, Morlat., P, Monforte, Ad, Kirk, O, Ryom, L, for the Data Collection on Adverse events of Anti-HIV Drugs (D:A:D), Study, Lazzarin, A, Castagna, A, Other departments, AII - Amsterdam institute for Infection and Immunity, APH - Amsterdam Public Health, Global Health, Infectious diseases, Paediatric Infectious Diseases / Rheumatology / Immunology, General Internal Medicine, Center of Experimental and Molecular Medicine, Graduate School, Medical Microbiology and Infection Prevention, Gastroenterology and Hepatology, APH - Health Behaviors & Chronic Diseases, Med Microbiol, Infect Dis & Infect Prev, MUMC+: DA MMI Staf (9), MUMC+: MA Alg Interne Geneeskunde (9), MUMC+: DA MMI Infectieserologie (9), MUMC+: DA MMI AIOS (9), RS: FHML non-thematic output, Mocroft, A, Lundgren, J, Fux, C, Morlat, P, Monforte, A, and Gori, A
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0301 basic medicine ,Male ,PROTEASE INHIBITOR ,Epidemiology ,Infectious Diseases ,Immunology ,Virology ,Research Support, U.S. Gov't, P.H.S ,HIV Infections ,SDG 3 – Goede gezondheid en welzijn ,Rate ratio ,THERAPY ,chemistry.chemical_compound ,0302 clinical medicine ,HIV ,antiretroviral ,kidney disease ,immune system diseases ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Medicine and Health Sciences ,HIV Infection ,030212 general & internal medicine ,Prospective Studies ,Renal Insufficiency ,Chronic ,Prospective cohort study ,Research Support, Non-U.S. Gov't ,Antiretrovirals ,virus diseases ,Lopinavir ,ASSOCIATION ,Middle Aged ,3. Good health ,Europe ,Antiretrovirals, HIV, chronic kidney disease ,[SDV.IMM]Life Sciences [q-bio]/Immunology ,Female ,NAIVE PATIENTS ,CREATININE ,Human ,Cohort study ,medicine.drug ,Glomerular Filtration Rate ,United State ,Adult ,medicine.medical_specialty ,TENOFOVIR DISOPROXIL FUMARATE ,RENAL-FUNCTION ,Adolescent ,Anti-HIV Agents ,Atazanavir Sulfate ,Renal function ,Infectious Disease ,Australia ,Humans ,Renal Insufficiency, Chronic ,Tenofovir ,United States ,Young Adult ,NO ,03 medical and health sciences ,EFAVIRENZ ,SDG 3 - Good Health and Well-being ,Internal medicine ,Journal Article ,medicine ,Creatinine ,business.industry ,Anti-HIV Agent ,medicine.disease ,030112 virology ,Atazanavir ,INFECTED INDIVIDUALS ,Prospective Studie ,lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4] ,chemistry ,RISK-FACTORS ,business ,chronic kidney disease ,Kidney disease - Abstract
BACKGROUND: Whether or not the association between some antiretrovirals used in HIV infection and chronic kidney disease is cumulative is a controversial topic, especially in patients with initially normal renal function. In this study, we aimed to investigate the association between duration of exposure to antiretrovirals and the development of chronic kidney disease in people with initially normal renal function, as measured by estimated glomerular filtration rate (eGFR).METHODS: In this prospective international cohort study, HIV-positive adult participants (aged ≥16 years) from the D:A:D study (based in Europe, the USA, and Australia) with first eGFR greater than 90 mL/min per 1·73 m(2) were followed from baseline (first eGFR measurement after Jan 1, 2004) until the occurrence of one of the following: chronic kidney disease; last eGFR measurement; Feb 1, 2014; or final visit plus 6 months (whichever occurred first). Chronic kidney disease was defined as confirmed (>3 months apart) eGFR lower than 60 mL/min per 1·73 m(2). The primary outcome was the occurrence of chronic kidney disease. Poisson regression was used to estimate the incidence rate of chronic kidney disease associated with cumulative exposure to tenofovir disoproxil fumarate, ritonavir-boosted atazanavir, ritonavir-boosted lopinavir, other ritonavir-boosted protease inhibitors, or abacavir.FINDINGS: Between Jan 1, 2004, and July 26, 2013, 23,905 eligible individuals from the D:A:D study were included. Participants had a median baseline eGFR of 110 mL/min per 1·73 m(2) (IQR 100-125), a median age of 39 years (33-45), and median CD4 cell count of 441 cells per mm(3) (294-628). During a median follow-up of 7·2 years (IQR 5·1-8·9), 285 (1%) of 23,905 people developed chronic kidney disease (incidence 1·76 per 1000 person-years of follow-up [95% CI 1·56-1·97]). After adjustment, we recorded a significant increase in chronic kidney disease associated with each additional year of exposure to tenofovir disoproxil fumarate (adjusted incidence rate ratio 1·14 [95% CI 1·10-1·19], pINTERPRETATION: In people with normal renal function, the annual incidence of chronic kidney disease increased for up to 6 years of exposure to tenofovir disoproxil fumarate, ritonavir-boosted atazanavir, or ritonavir-boosted lopinavir therapy. Although the absolute number of new cases of chronic kidney disease was modest, treatment with these antiretrovirals might result in an increasing and cumulative risk of chronic kidney disease. Patients on potentially nephrotoxic antiretrovirals or at high risk of chronic kidney disease should be closely monitored.FUNDING: The Highly Active Antiretroviral Therapy Oversight Committee.
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- 2016
21. Prevalence of human respiratory syncytial virus circulating in Iran
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Salimi, Vahid, Tavakoli-Yaraki, Masoumeh, Yavarian, Jila, Bont, LJ, Mokhtari-Azad, Talat, Salimi, Vahid, Tavakoli-Yaraki, Masoumeh, Yavarian, Jila, Bont, LJ, and Mokhtari-Azad, Talat
- Published
- 2016
22. Respiratory Syncytial Virus Preterm (32-36 Completed Weeks Gestation) Risk Estimation Measure for RSV Hospitalization in Ireland : A Prospective Study
- Author
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Sheridan-Pereira, Margaret, Murphy, Joan, Sloan, Julie, Crispino, Gloria, Leahy, Anne, Corcoran, J David, Dempsey, Eugene, Elnazir, Basil, Gavin, Patrick, Sharif, Farhana, Gul, Rizwan, Satas, Salius, Murphy, John, Gormally, Siobhan, Shanaa, Issam, Waldron, David, Mc Mahon, Paul, Carson, John, Blanken, Maarten, Bont, LJ, Paes, Bosco, Sheridan-Pereira, Margaret, Murphy, Joan, Sloan, Julie, Crispino, Gloria, Leahy, Anne, Corcoran, J David, Dempsey, Eugene, Elnazir, Basil, Gavin, Patrick, Sharif, Farhana, Gul, Rizwan, Satas, Salius, Murphy, John, Gormally, Siobhan, Shanaa, Issam, Waldron, David, Mc Mahon, Paul, Carson, John, Blanken, Maarten, Bont, LJ, and Paes, Bosco
- Published
- 2016
23. Prevalence of human respiratory syncytial virus circulating in Iran
- Author
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Child Health, Infection & Immunity, Salimi, Vahid, Tavakoli-Yaraki, Masoumeh, Yavarian, Jila, Bont, LJ, Mokhtari-Azad, Talat, Child Health, Infection & Immunity, Salimi, Vahid, Tavakoli-Yaraki, Masoumeh, Yavarian, Jila, Bont, LJ, and Mokhtari-Azad, Talat
- Published
- 2016
24. Respiratory Syncytial Virus Preterm (32-36 Completed Weeks Gestation) Risk Estimation Measure for RSV Hospitalization in Ireland: A Prospective Study
- Author
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Child Health, Infection & Immunity, Infectieziekten onderzoek1 (Bont), Sheridan-Pereira, Margaret, Murphy, Joan, Sloan, Julie, Crispino, Gloria, Leahy, Anne, Corcoran, J David, Dempsey, Eugene, Elnazir, Basil, Gavin, Patrick, Sharif, Farhana, Gul, Rizwan, Satas, Salius, Murphy, John, Gormally, Siobhan, Shanaa, Issam, Waldron, David, Mc Mahon, Paul, Carson, John, Blanken, Maarten, Bont, LJ, Paes, Bosco, Child Health, Infection & Immunity, Infectieziekten onderzoek1 (Bont), Sheridan-Pereira, Margaret, Murphy, Joan, Sloan, Julie, Crispino, Gloria, Leahy, Anne, Corcoran, J David, Dempsey, Eugene, Elnazir, Basil, Gavin, Patrick, Sharif, Farhana, Gul, Rizwan, Satas, Salius, Murphy, John, Gormally, Siobhan, Shanaa, Issam, Waldron, David, Mc Mahon, Paul, Carson, John, Blanken, Maarten, Bont, LJ, and Paes, Bosco
- Published
- 2016
25. Development of a definition for rapid progression (RP) of renal function in HIV-positive persons:the D:A:D study
- Author
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Kamara, David A., Ryom, Lene, Ross, Michael, Kirk, Ole, Reiss, Peter, Morlat, Philippe, Moranne, Olivier, Fux, Christoph A., Mocroft, Amanda, Sabin, Caroline, Lundgren, Jens D., Smith, Colette J, D:A:D study, Group., Quiros, Roldan, Powderly B, M. E., Shortman, N, Moecklinghoff, C, Reilly, G, Franquet, X, Ryom, L, Sabin, Ca, Kamara, D, Smith, C, Phillips, A, Mocroft, A, Tverland, J, Mansfeld, M, Nielsen, J, Raben, D, Lundgren, Jd, Brandt, R, Rickenbach, M, Fanti, I, Krum, E, Hillebregt, M, Geffard, S, Sundström, A, Delforge, M, Fontas, E, Torres, F, Mcmanus, H, Wright, S, Kjær, J, Sjøl, A, Meidahl, P, Helweg-Larsen, J, Iversen, J, Kirk, O, Reiss, P, Ross, M, Fux, Ca, Morlat, P, Moranne, O, Kesselring, Am, Kamara, Da, Weber, R, Pradier, C, Friis-Møller, N, Kowalska, J, Sabin, C, Law, M, d'Arminio Monforte, A, Dabis, F, Bruyand, M, Bower, M, Fätkenheuer, G, Donald, A, Grulich, A, Zaheri, S, Gras, L, Prins, Jm, Kuijpers, Tw, Scherpbier, Hj, van der Meer JT, Wit, Fw, Godfried, Mh, van der Poll, D, Nellen, Fj, Lange, Jm, Geerlings, Se, van Vugt, M, Pajkrt, D, Bos, D, van der Valk, D, Grijsen, Ml, Wiersinga, Wj, Goorhuis, A, Hovius, Jw, Lowe, S, Lashof, A, Posthouwer, D, Ammerlaan, Hs, Pronk, Mj, van der Ende ME, de Vries-Sluijs TE, Schurink, Ca, Nouwen, Jl, Verbon, A, Rijnders, Bj, van Gorp EC, van der Feltz, M, Driessen, Gj, van Rossum AM, Branger, J, Schippers, F, van Nieuwkoop, C, van Elzakker EP, Groeneveld, Ph, Bouwhuis, Jw, Soetekouw, R, ten Kate RW, Kroon, Fp, van Dissel JT, Arend, Sm, de Boer MG, Jolink, H, ter Vollaard HJ, Bauer, Mp, den Hollander JG, Pogany, K, van Twillert, D, Kortmann, W, Stuart, Jw, Diederen, Bm, Leyten, Ms, Gelinck, Lb, Kootstra, Gj, Delsing, Ce, Brinkman, K, Blok, Wl, Frissen, Ph, Schouten, We, van den Berk GE, van Kasteren ME, Brouwer, Ae, Veenstra, J, Lettinga, Kd, Mulder, Jw, Vrouenraets, Sm, Lauw, Fn, van Eeden, A, Verhagen, Dw, Sprenger, Hg, Doedens, R, Scholvinck, Eh, van Assen, S, Bierman, Wf, Koopmans, Pp, Keuter, M, van der Ven AJ, ter Hofstede HJ, Dofferhoff, As, Warris, A, van Crevel, R, Hoepelman, Ai, Mudrikova, T, Schneider, Mm, Ellerbroek, Pm, Oosterheert, Jj, Arends, Je, Wassenberg, Mw, Barth, Re, van Agtmael, M, Perenboom, Rm, Claessen, Fa, Bomers, M, Peters, Ej, Geelen, Sp, Wolfs, Tf, Bont, Lj, Richter, C, van der Berg JP, Gisolf, Eh, van den Berge, M, Stegeman, A, van Vonderen MG, van Houte DP, Weijer, S, el Moussaoui, R, Winkel, C, Muskiet, F, Durand, Voigt, R, Chêne, G, Lawson-Ayayi, S, Thiébaut, R, Bonnal, F, Bonnet, F, Bernard, N, Caunègre, L, Cazanave, C, Ceccaldi, J, Chambon, D, Chossat, I, Dauchy, Fa, De Witte, S, Dupon, M, Duffau, P, Dutronc, H, Farbos, S, Gaborieau, V, Gemain, Mc, Gerard, Y, Greib, C, Hessamfar, M, Lacoste, D, Lataste, P, Lafarie, S, Lazaro, E, Malvy, D, Meraud, Jp, Mercié, P, Monlun, E, Neau, D, Ochoa, A, Pellegrin, Jl, Pistone, T, Ragnaud, Jm, Receveur, Mc, Tchamgoué, S, Vandenhende, Ma, Viallard, Jf, Moreau, Jf, Pellegrin, I, Fleury, H, Lafon, Me, Masquelier, B, Trimoulet, P, Breilh, D, Haramburu, F, Miremont-Salamé, G, Blaizeau, Mj, Decoin, M, Delaune, J, Delveaux, S, D'Ivernois, C, Hanapier, C, Leleux, O, Uwamaliya-Nziyumvira, B, Sicard, X, Palmer, G, Touchard, D, Petoumenos, K, Bendall, C, Moore, R, Edwards, S, Hoy, J, Watson, K, Roth, N, Nicholson, J, Bloch, M, Franic, T, Baker, D, Vale, R, Carr, A, Cooper, D, Chuah, J, Ngieng, M, Nolan, D, Skett, J, Calvo, G, Mateu, S, Domingo, P, Sambeat, Ma, Gatell, J, Del Cacho, E, Cadafalch, J, Fuster, M, Codina, C, Sirera, G, Vaqué, A, De Wit, S, Clumeck, N, Necsoi, C, Gennotte, Af, Gerard, M, Kabeya, K, Konopnicki, D, Libois, A, Martin, C, Payen, Mc, Semaille, P, Van Laethem, Y, Neaton, J, Bartsch, G, El-Sadr, Wm, Thompson, G, Wentworth, D, Luskin-Hawk, R, Telzak, E, Abrams, Di, Cohn, D, Markowitz, N, Arduino, R, Mushatt, D, Friedland, G, Perez, G, Tedaldi, E, Fisher, E, Gordin, F, Crane, Lr, Sampson, J, Baxter, J, Lundgren, J, Cozzi-Lepri, A, Grint, D, Podlekareva, D, Peters, L, Reekie, J, Fischer, Ah, Losso, M, Elias, C, Vetter, N, Zangerle, R, Karpov, I, Vassilenko, A, Mitsura, Vm, Suetnov, O, Colebunders, R, Vandekerckhove, L, Hadziosmanovic, V, Kostov, K, Machala, L, Begovac, J, Jilich, D, Sedlacek, D, Kronborg, G, Gerstoft, J, Benfield, T, Larsen, M, Katzenstein, T, Hansen, Ab, Skinhøj, P, Pedersen, C, Ostergaard, L, Zilmer, K, Smidt, J, Ristola, M, Katlama, C, Viard, J, Girard, P, Livrozet, Jm, Vanhems, P, Rockstroh, J, Schmidt, R, van Lunzen, J, Degen, O, Stellbrink, Hj, Staszewski, S, Bickel, M, Kosmidis, J, Gargalianos, P, Xylomenos, G, Perdios, J, Panos, G, Filandras, A, Karabatsaki, E, Sambatakou, H, Banhegyi, D, Mulcahy, F, Yust, I, Turner, D, Burke, M, Pollack, S, Hassoun, G, Maayan, S, Vella, S, Esposito, R, Mazeu, I, Mussini, C, Arici, C, Pristera, R, Mazzotta, F, Gabbuti, A, Vullo, V, Lichtner, M, Chirianni, A, Montesarchio, E, Gargiulo, M, Antonucci, G, Testa, A, Narciso, P, Vlassi, C, Zaccarelli, M, Lazzarin, A, Castagna, A, Gianotti, N, Galli, M, Ridolfo, A, Rozentale, B, Zeltina, I, Chaplinskas, S, Hemmer, R, Staub, T, Ormaasen, V, Maeland, A, Bruun, J, Knysz, B, Gasiorowski, J, Horban, A, Bakowska, E, Grzeszczuk, A, Flisiak, R, Boron-Kaczmarska, A, Pynka, M, Parczewski, M, Beniowski, M, Mularska, E, Trocha, H, Jablonowska, E, Malolepsza, E, Wojcik, K, Antunes, F, Doroana, M, Caldeira, L, Mansinho, K, Maltez, F, Duiculescu, D, Rakhmanova, A, Babes, V, Zakharova, N, Jevtovic, D, Mokráš, M, Staneková, D, Tomazic, J, González-Lahoz, J, Soriano, V, Labarga, P, Medrano, J, Moreno, S, Rodriguez, Jm, Clotet, B, Jou, A, Paredes, R, Tural, C, Puig, J, Bravo, I, Gatell, Jm, Miró, Jm, Gutierrez, M, Karlsson, A, Mateo, G, Flamholc, L, Ledergerber, B, Francioli, P, Cavassini, M, Hirschel, B, Boffi, E, Kravchenko, E, Furrer, H, Battegay, M, Elzi, L, Chentsova, N, Frolov, V, Kutsyna, G, Servitskiy, S, Krasnov, M, Barton, S, Johnson, Am, Mercey, D, Johnson, Ma, Murphy, M, Weber, J, Scullard, G, Fisher, M, Leen, C, Morfeldt, L, Thulin, G, Åkerlund, B, Koppel, K, Håkangård, C, Moroni, M, Angarano, G, Antinori, A, Armignacco, O, Castelli, F, Cauda, R, Di Perri, G, Iardino, R, Ippolito, G, Perno, Cf, von Schloesser, F, Viale, P, Ceccherini-Silberstein, F, Girardi, E, Lo Caputo, S, Puoti, M, Andreoni, M, Ammassari, A, Balotta, C, Bonfanti, P, Bonora, S, Borderi, M, Capobianchi, Mr, Cingolani, A, Cinque, P, De Luca, A, Di Biagio, A, Gori, A, Guaraldi, G, Lapadula, G, Madeddu, G, Maggiolo, F, Marchetti, G, Marcotullio, S, Monno, L, Quiros, E, Rusconi, S, Cicconi, P, Formenti, T, Galli, L, Lorenzini, P, Giacometti, A, Costantini, A, Santoro, C, Suardi, C, Vanino, E, Verucchi, G, Quiros Roldan, E, Minardi, C, Quirino, T, Abeli, C, Manconi, Pe, Piano, P, Vecchiet, J, Falasca, K, Sighinolfi, L, Segala, D, Cassola, G, Viscoli, G, Alessandrini, A, Piscopo, R, Mazzarello, G, Mastroianni, C, Belvisi, V, Caramma, I, Castelli, Ap, Rizzardini, G, Ridolfo, Al, Piolini, R, Salpietro, S, Carenzi, L, Moioli, Mc, Puzzolante, C, Onofrio, M, Abrescia, N, Guida, Mg, Baldelli, F, Francisci, D, Parruti, G, Ursini, T, Magnani, G, Ursitti, Ma, d' Avino, A, Gallo, L, Nicastri, E, Acinapura, R, Capozzi, M, Libertone, R, Tebano, G, Cattelan, A, Mura, Ms, Caramello, P, Orofino, Gc, Sciandra, M, Pellizzer, G, Manfrin, V, Caissotti, C, Dellamonica, P, Bernard, E, Cua, E, De Salvador- Guillouet, F, Durant, J, Ferrando, S, Mondain-Miton, V, Naqvi, A, Perbost, I, Prouvost-Keller, B, Pillet, S, Pugliese, P, Rahelinirina, V, Roger, Pm, Dollet, K, Aubert, V, Barth, J, Bernasconi, E, Böni, J, Bucher, Hc, Burton- Jeangros, C, Calmy, A, Egger, M, Fehr, J, Fellay, J, Gorgievski, M, Günthard, H, Haerry, D, Hasse, B, Hirsch, Hh, Hösli, I, Kahlert, C, Kaiser, L, Keiser, O, Klimkait, T, Kovari, H, Martinetti, G, de Tejada BM, Metzner, K, Müller, N, Nadal, D, Pantaleo, G, Rauch, A, Regenass, A, Rudin, C, Schmid, P, Schultze, D, Schöni-Affolter, F, Schüpbach, J, Speck, R, Taffé, P, Tarr, P, Telenti, A, Trkola, A, Vernazza, P, Yerly, S., AII - Amsterdam institute for Infection and Immunity, APH - Amsterdam Public Health, Global Health, Other departments, Infectious diseases, Paediatric Infectious Diseases / Rheumatology / Immunology, General Internal Medicine, Dermatology, Medical Microbiology and Infection Prevention, Sea to Shore Alliance, University of Florida [Gainesville] (UF), Observatoire des Micro et Nano Technologies (OMNT - UMS 2920), Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Structures et propriétés d'architectures moléculaire (SPRAM - UMR 5819), Institut Nanosciences et Cryogénie (INAC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Service de médecine interne et maladies infectieuses [Bordeaux], CHU Bordeaux [Bordeaux]-Groupe hospitalier Saint-André, Département de santé publique, Centre Hospitalier Universitaire de Nice (CHU Nice)-Hôpital Larchet, Service de néphrologie, Hôpital Pasteur [Nice] (CHU)-Centre Hospitalier Universitaire de Nice (CHU Nice), Department of primary care and population sciences, University College of London [London] (UCL), Research Department of Infection and Population Health [London], Economics, Umeå University, Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Institut Nanosciences et Cryogénie (INAC), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])
- Subjects
Adult ,Male ,CHRONIC KIDNEY-DISEASE ,Internationality ,FUNCTION DECLINE ,diagnosis ,nephrology ,Chronic kidney disease ,Estimated glomerular filtration rate ,HIV ,Kidney disease ,Rapid progression ,D:A:D study Group ,HIV Infections ,urologic and male genital diseases ,Sensitivity and Specificity ,Severity of Illness Index ,GLOMERULAR-FILTRATION-RATE ,renal insufficiency ,NO ,MORTALITY RISK ,ANTIRETROVIRAL THERAPY ,80 and over ,Humans ,chronic kidney disease ,estimated glomerular filtration rate ,hiv ,kidney disease ,rapid progression ,adult ,aged ,aged, 80 and over ,diagnosis, computer-assisted ,disease progression ,female ,glomerular filtration rate ,hiv infections ,humans ,internationality ,male ,middle aged ,renal insufficiency, chronic ,reproducibility of results ,sensitivity and specificity ,algorithms ,severity of illness index ,Diagnosis, Computer-Assisted ,Renal Insufficiency, Chronic ,ComputingMilieux_MISCELLANEOUS ,BODY-SURFACE AREA ,POPULATION ,Aged ,Aged, 80 and over ,INFECTED PATIENTS ,Reproducibility of Results ,1103 Clinical Sciences ,ASSOCIATION ,Urology & Nephrology ,Middle Aged ,chronic ,INDIVIDUALS ,[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology ,computer-assisted ,Disease Progression ,Female ,Algorithms ,Research Article ,Glomerular Filtration Rate - Abstract
BACKGROUND: No consensus exists on how to define abnormally rapid deterioration in renal function (Rapid Progression, RP). We developed an operational definition of RP in HIV-positive persons with baseline estimated glomerular filtration rate (eGFR) >90 ml/min/1.73 m2 (using Cockcroft Gault) in the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study from 2004 to 2011. METHODS: Two definitions were evaluated; RP definition A: An average eGFR decline (slope) ≥5 ml/min/1.73 m2/year over four years of follow-up with ≥3 eGFR measurements/year, last eGFR
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- 2014
26. A multifaceted 'omics' approach for addressing the challenge of antimicrobial resistance
- Author
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Cohen, Asi, Bont, LJ, Engelhard, Dan, Moore, Edward, Fernandez, David, Kreisberg-Greenblatt, Racheli, Oved, Kfir, Eden, Eran, Hays, John P., Cohen, Asi, Bont, LJ, Engelhard, Dan, Moore, Edward, Fernandez, David, Kreisberg-Greenblatt, Racheli, Oved, Kfir, Eden, Eran, and Hays, John P.
- Published
- 2015
27. Neutrophils in respiratory syncytial virus infection : A target for asthma prevention
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Geerdink, Ruben J., Pillay, Janesh, Meyaard, Linde, Bont, LJ, Geerdink, Ruben J., Pillay, Janesh, Meyaard, Linde, and Bont, LJ
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- 2015
28. Challenges and Opportunities in Developing Respiratory Syncytial Virus Therapeutics
- Author
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Simoes, Eric A. F., DeVincenzo, John P., Boeckh, Michael, Bont, LJ, Crowe, James E., Griffiths, Paul, Hayden, Frederick G., Hodinka, Richard L., Smyth, Rosalind L., Spencer, Keith, Thirstrup, Steffen, Walsh, Edward E., Whitley, Richard J., Simoes, Eric A. F., DeVincenzo, John P., Boeckh, Michael, Bont, LJ, Crowe, James E., Griffiths, Paul, Hayden, Frederick G., Hodinka, Richard L., Smyth, Rosalind L., Spencer, Keith, Thirstrup, Steffen, Walsh, Edward E., and Whitley, Richard J.
- Published
- 2015
29. Neutrophils in respiratory syncytial virus infection: A target for asthma prevention
- Author
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Child Health, Infection & Immunity, CTI Meyaard, AIOS Anesthesiologie, Other research (not in main researchprogram), Geerdink, Ruben J., Pillay, Janesh, Meyaard, Linde, Bont, LJ, Child Health, Infection & Immunity, CTI Meyaard, AIOS Anesthesiologie, Other research (not in main researchprogram), Geerdink, Ruben J., Pillay, Janesh, Meyaard, Linde, and Bont, LJ
- Published
- 2015
30. A multifaceted 'omics' approach for addressing the challenge of antimicrobial resistance
- Author
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Infectieziekten onderzoek1 (Bont), Child Health, Infection & Immunity, Cohen, Asi, Bont, LJ, Engelhard, Dan, Moore, Edward, Fernandez, David, Kreisberg-Greenblatt, Racheli, Oved, Kfir, Eden, Eran, Hays, John P., Infectieziekten onderzoek1 (Bont), Child Health, Infection & Immunity, Cohen, Asi, Bont, LJ, Engelhard, Dan, Moore, Edward, Fernandez, David, Kreisberg-Greenblatt, Racheli, Oved, Kfir, Eden, Eran, and Hays, John P.
- Published
- 2015
31. Challenges and Opportunities in Developing Respiratory Syncytial Virus Therapeutics
- Author
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Infectieziekten onderzoek1 (Bont), Child Health, Infection & Immunity, Simoes, Eric A. F., DeVincenzo, John P., Boeckh, Michael, Bont, LJ, Crowe, James E., Griffiths, Paul, Hayden, Frederick G., Hodinka, Richard L., Smyth, Rosalind L., Spencer, Keith, Thirstrup, Steffen, Walsh, Edward E., Whitley, Richard J., Infectieziekten onderzoek1 (Bont), Child Health, Infection & Immunity, Simoes, Eric A. F., DeVincenzo, John P., Boeckh, Michael, Bont, LJ, Crowe, James E., Griffiths, Paul, Hayden, Frederick G., Hodinka, Richard L., Smyth, Rosalind L., Spencer, Keith, Thirstrup, Steffen, Walsh, Edward E., and Whitley, Richard J.
- Published
- 2015
32. PO-0401 Il-6 Polymorphism At Position-174 In Newborn Infants With Perinatal Arterial Ischaemic Stroke: Association With Adverse Outcome
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Harteman, JC, primary, Willemen, HLDM, additional, Heynen, CJ, additional, Huisman, A, additional, Bont, LJ, additional, van Bel, F, additional, Benders, MJNL, additional, de Vries, LS, additional, and Groenendaal, F, additional
- Published
- 2014
- Full Text
- View/download PDF
33. Ventilator and viral induced inflammation
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van Vught, Hans, Bont, LJ, Jansen, Koos, Hennus, M.P., van Vught, Hans, Bont, LJ, Jansen, Koos, and Hennus, M.P.
- Published
- 2013
34. Ventilator and viral induced inflammation
- Author
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Child Health, Infection & Immunity, Intensive care, Cluster B, van Vught, Hans, Bont, LJ, Jansen, Koos, Hennus, M.P., Child Health, Infection & Immunity, Intensive care, Cluster B, van Vught, Hans, Bont, LJ, Jansen, Koos, and Hennus, M.P.
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- 2013
35. Host response to respiratory syncytial virus : genetic associations and effect on disease severity
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Kimpen, JLL, Janssen, R., Bont, LJ, Schuurhof, A., Kimpen, JLL, Janssen, R., Bont, LJ, and Schuurhof, A.
- Published
- 2012
36. Neonatal innate immunity - A translational perspective
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Kimpen, JLL, Meyaard, Linde, Bont, LJ, Belderbos, M.E., Kimpen, JLL, Meyaard, Linde, Bont, LJ, and Belderbos, M.E.
- Published
- 2012
37. Host response to respiratory syncytial virus : genetic associations and effect on disease severity
- Author
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Child Health, Infection & Immunity, Cluster B, Kimpen, JLL, Janssen, R., Bont, LJ, Schuurhof, A., Child Health, Infection & Immunity, Cluster B, Kimpen, JLL, Janssen, R., Bont, LJ, and Schuurhof, A.
- Published
- 2012
38. Neonatal innate immunity - A translational perspective
- Author
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Child Health, Infection & Immunity, Cluster B, Kimpen, JLL, Meyaard, L, Bont, LJ, Belderbos, M.E., Child Health, Infection & Immunity, Cluster B, Kimpen, JLL, Meyaard, L, Bont, LJ, and Belderbos, M.E.
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- 2012
39. RSV bronchiolitis in healthy term infants: prediction and pathogenesis
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Kimpen, JLL, Visser, G.H.A., Bont, LJ, Rovers, M.M., Houben, M.L., Kimpen, JLL, Visser, G.H.A., Bont, LJ, Rovers, M.M., and Houben, M.L.
- Published
- 2011
40. Severe RSV infections in children with Down syndrome : the contribution of an impaired immune system
- Author
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Kimpen, JLL, van Furth, A.M., Bont, LJ, Bloemers, B.L.P., Kimpen, JLL, van Furth, A.M., Bont, LJ, and Bloemers, B.L.P.
- Published
- 2010
41. Severe RSV infections in children with Down syndrome : the contribution of an impaired immune system
- Author
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Infection & Immunity, Cluster B, Kimpen, JLL, van Furth, A.M., Bont, LJ, Bloemers, B.L.P., Infection & Immunity, Cluster B, Kimpen, JLL, van Furth, A.M., Bont, LJ, and Bloemers, B.L.P.
- Published
- 2010
42. Respiratory syncytial virus induced recurrent wheeze: genetic determinants and preventive glucocorticosteroid treatment
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Kimpen, JLL, Bont, LJ, Rovers, M.M., Ermers, M.J.J., Kimpen, JLL, Bont, LJ, Rovers, M.M., and Ermers, M.J.J.
- Published
- 2009
43. Recurrent Wheeze Following Respiratory Syncytial Virus Bronchiolitis in Children with Down Syndrome.
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Bloemers, BL, primary, van Furth, AM, additional, Weijerman, ME, additional, Gemke, RJ, additional, Broers, CJ, additional, Kimpen, JL, additional, and Bont, LJ, additional
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- 2009
- Full Text
- View/download PDF
44. The effect of high dose inhaled corticosteroids on wheeze in infants after respiratory syncytial virus infection: randomised double blind placebo controlled trial.
- Author
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Ermers MJJ, Rovers MM, van Woensel JB, Kimpen JLL, Bont LJ, and RSV Corticosteroid Study Group
- Published
- 2009
45. Down syndrome: a novel risk factor for respiratory syncytial virus bronchiolitis--a prospective birth-cohort study.
- Author
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Bloemers BL, van Furth AM, Weijerman ME, Gemke RJ, Broers CJ, van den Ende K, Kimpen JL, Strengers JL, and Bont LJ
- Published
- 2007
- Full Text
- View/download PDF
46. RSV infection and wheeze in moderate-to-late preterm infants : prediction and cost-effectiveness
- Author
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Blanken, M.O., Bont, LJ, Rovers, M.M., and University Utrecht
- Subjects
risk prediction ,recurrent wheezing ,late prematurity ,RSV infection ,cost-effectiveness ,Moderate prematurity - Abstract
The main objective of this project was to develop a cost-effectiveness model for policymakers to specifically target the disease burden of Respiratory Syncytial Virus (RSV) bronchiolitis in late premature children. Within this project we have shown that although RSV bronchiolitis is the main reason for hospitalization and wheezing in the first year of life, it is not a major cause of asthma diagnosis at the age of 6 years. Prematurity is the most important risk factor for a serious course of a RSV infection. Within this project we have developed a risk score instrument with which we can identify a group of late preterm children of 32-36 weeks of gestation with two to three times the risk of hospitalization with an RSV infection. We call these children the "high risk" group although late premature children in themselves already have an increased risk of hospitalization. This high risk group is also the group in which we can best reduce the burden of disease by protecting them against the virus with RSV immunoprophylaxis (palivizumab). We have developed a cost-effectiveness model in which targeted RSV immunoprophylaxis for high-risk late preterm children was compared to no protection. We use a societal perspective and a time horizon of 1 year. The results of the cost-effectiveness analysis show that against the current cost of prophylaxis, the use of RSV-immunoprophylaxis palivizumab is not cost-effective (ICER> 200,000 / QALY). This model is directly applicable to future analyzes of improved immunoprophylaxis (extended half-life), cheaper immunoprophylaxis (biosimilar) or an RSV vaccine for infants or for the pregnant mother (maternal). With these products in development and our research contribution, we are hopeful for a future with a lower RSV disease burden for preterm children.
- Published
- 2019
47. Improving diagnosis of bacterial infections : Research without gold standard
- Author
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van Houten, C.B., Bont, LJ, Sanders, Elisabeth, and University Utrecht
- Subjects
panel diagnosis ,antibiotic overuse ,TRAIL ,Bacterial infection ,CRP ,reference standard - Abstract
Timely antibiotic treatment improves the outcome of patients with bacterial infections, but antibiotics are not indicated in case of viral infections. Unfortunately, it is often not possible to differentiate between bacterial and viral infections based on clinical judgement alone, even when using available blood tests. Different aspects of this diagnostic dilemma were studied in this thesis. First, we evaluated the consequences of this complicated diagnostic process on antibiotic use. We used an expert panel of physicians to assign a viral or bacterial diagnosis to each individual case. We found that one third of all children infected with the respiratory syncytial virus (RSV) and without presumed bacterial co-infections were treated unnecessarily with antibiotics. When studying children and adults with respiratory tract infections (RTI), we found that the proportion of viral infections was larger in children than in adults (74% versus 38%). However, antibiotic overuse was less frequent among children with viral RTI than adults with viral RTI (37% versus 83%). These findings support the need for effective diagnostics in RTI patients of all ages. Second, we validated a novel diagnostic to differentiate between viral and bacterial infections. Therefore, we performed a double-blinded, prospective, international study (the OPPORTUNITY study) in children below the age of five. We studied a novel assay combining three proteins: tumour necrosis factor-related apoptosis-inducing ligand (TRAIL), interferon gamma induced protein-10 (IP-10), and C-reactive protein (CRP). We showed that this combination of biomarkers upregulated by viral and bacterial infections had a high diagnostic value. The assay is especially helpful for ruling out bacterial infections. The number of false positives decreased with 51% if the combination assay was used instead of CRP alone. This result suggests that this assay has the potential to reduce antibiotic misuse in young children. In addition to biomarkers, clinical signs and symptoms play an important role when physicians diagnose febrile children. We therefore integrated the above-mentioned combination assay in an existing clinical prediction model for febrile children. This model includes clinical parameters and CRP and was updated with the combination assay. The updated model was more accurate in predicting serious bacterial infections compared to the model with CRP as the only biomarker. Third, the absence of a gold standard to diagnose bacterial infections is troublesome in diagnostic studies. In this thesis an expert panel reference standard was used to establish patient outcomes (i.e. bacterial or viral infection). We evaluated the reproducibility of such an expert panel diagnosis. We found that a three-expert panel provides more reproducible diagnosis than an individual expert. Even with a time interval of three years, the intra-panel agreement was high. Increasing the size of the expert panel to seven experts has no major advantage. In this thesis we showed that antibiotic overuse is a large problem in children and adults. A new diagnostic test can help physicians to differentiate between bacterial and viral infections and can decrease antibiotic overuse in young children. Our findings support the need for implementation research to examine the utility of this assay.
- Published
- 2019
48. Respiratory syncytial virus-related disease burden in young children
- Author
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Scheltema, N.M., Bont, LJ, van der Ent, Cornelis, and University Utrecht
- Subjects
Prevention ,Maternal vaccination ,respiratory system ,Respiratory syncytial virus ,Mortality ,Children ,Asthma ,Model - Abstract
Respiratory tract infection with respiratory syncytial virus (RSV) is a leading cause of hospitalisation in young children. In high-income countries RSV-related mortality is generally infrequent, but globally RSV is an important cause of pneumonia-related mortality in children younger than 5 years. There is no treatment for RSV infection except supportive care and no vaccine available to prevent RSV infection. Passive immunisation with palivizumab, a humanised monoclonal antibody, is the only form of RSV prevention currently available. However, due to its cost palivizumab is only indicated in certain high-risk infant populations from high-income countries. Several immunisation strategies are currently under development with maternal immunisation being in phase-3 of clinical development. Due to immaturity of the immune system in neonates, paediatric vaccination is not possible directly after birth but aimed at an age of approximately two to three months. Vaccination of pregnant women is therefore a promising alternative if the youngest infants are targeted to be protected. Three different aspects of the RSV disease burden in young children were studied in this thesis. Global RSV-related childhood mortality was the first aspect studied. Clinical characteristics including age at death of children with fatal RSV infection were unknown. Individual patient data of 358 children who had died with RSV in hospitals across the world were described. It was found that at least 28% of children with RSV-related in-hospital death have comorbidities. The presence of comorbidity influences the age distribution of RSV-related in-hospital death, especially in high-income countries. Most children in low-income and middle-income countries are younger than six months at the time of RSV-related in-hospital death. The second aspect consisted of the potential effect of maternal vaccination on life-threatening and fatal RSV infection during infancy. While in phase-3 of clinical development, the expected effect of maternal vaccination on RSV prevention was still unknown. A mathematical model was developed to describe different factors that influence maternal vaccine efficacy. By applying this mathematical model to data from three cohorts of patients it was predicted that maternal vaccination against RSV may substantially decrease the number of life-threatening RSV infections in infants. Children with comorbidities (based on age at life-threatening infection) or preterm birth are likely to benefit less from maternal vaccination against RSV than healthy term children. The third aspect comprised the causal relationship between RSV infection and asthma development. Single, assessor-blinded follow-up of the randomised, placebo-controlled MAKI trial showed that prevention of RSV infection in otherwise healthy late preterm infants reduces the risk of parent-reported asthma at age six years, which is mostly explained by differences in infrequent wheeze. RSV prevention does not affect parent-reported frequent wheeze, lung function or physician-diagnosed asthma at age six years. Altogether, this follow-up trial demonstrates that despite the association found between RSV infection and asthma in non-randomised studies, a causal relationship seems unlikely in otherwise healthy late preterm infants. However, the trial may have missed detection of smaller, but clinically relevant effects of RSV prevention on different asthma phenotypes as a result of sample size. In summary, this thesis describes global RSV-related mortality, the potential of maternal vaccination and the relationship between RSV infection and asthma development.
- Published
- 2018
49. Urological care for children with spina bifida : Individual, tailored and without antibiotic prophylaxis
- Author
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Zegers, S.H.J., Bont, LJ, de Jong-de Vos van Steenwijk, Teau, and University Utrecht
- Subjects
spina bifida ,quality of life ,antibiotic prophylaxis ,clean intermittent catheterization ,urinary tract infections ,leukocyte esterase test ,antibiotics - Abstract
In our SPIN UTI study, we have focused on the urological problems, urinary tract infections and Quality of Life in spina bifida children. For eighteen months, we have analyzed the diagnosing, treatment and prevention of urinary tract infections in 176 children with spina bifida from Utrecht and Leuven and their Quality of Life. We have evaluated the European protocols for prevention, evaluation and treatment of urinary tract infections and urological care for children with spina bifida. We have concluded from this survey that there is no consensus in urological care. We have evaluated the accuracy of home testing with a leukocyte esterase test and a dip slide urine culture. This study reveals that a negative esterase test in home setting properly excludes bacteriuria and urinary tract infection: when the esterase test is negative, there is no indication for culture or antibiotic treatment. We have also evaluated the value of antibiotic prophylaxis for prevention of urinary tract infections in our cohort. Biweekly urine samples were evaluated using a leukocyte esterase test and agar plated urine culture. Non-febrile urinary tract infections occurred more often in the discontinuation group, statistically significant, but clinically not relevant: prophylaxis has to be administered for more than 2 years to prevent one urinary tract infection. A significant number of patients switched back to prophylaxis because of recurrent urinary tract infections. We recommend that antibiotic prophylaxis should only be continued in spina bifida children with a high rate of febrile urinary tract infections. The nearly 5,000 bacterial cultures in our study enabled us to evaluate the influence of stopping antibiotic prophylaxis on the bacterial resistance pattern. Overall, our study showed a decrease in bacterial resistance to commonly used antibiotics once prophylaxis is stopped. When the use of prophylaxis is necessary, trimethoprim has the least negative influence on bacterial resistance. Oral antibiotic treatment is adequate for urinary tract infections in clinically not-ill children. In our cohort, nitrofurantoin is first choice medication for a non-febrile urinary tract infection without prophylaxis. We evaluated the Quality of Life in our cohort with the KINDL-R questionnaire on the domains of physical and emotional well-being, self-esteem, family, friends and school. Compared to healthy controls, both the children and their parents have significantly lower Quality of Life scores. Patients have higher scores than their parents. Severity of morbidity is poorly correlated with perceived Quality of Life, and should not be used to estimate a patients well-being. In our study we have shown that there is no current consensus on nephro-urological care in patients with spina bifida. Proper urological care can be improved by implementing our findings: 1. antibiotic prophylaxis is only warranted in children with frequently recurring urinary tract infections, 2. bacterial susceptibility to commonly used therapeutic antibiotics is higher when refraining from every day antibiotic prophylaxis, 3. exclusion of a suspected urinary tract infection can be done at home with a simple leukocyte esterase test, and 4. individual repetitive assessment of Quality of Life ensures tailored counseling and psychosocial care in spina bifida.
- Published
- 2017
50. Immunity to respiratory syncytial virus : a clinical perspective
- Author
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Faber, T.E., Bont, LJ, and University Utrecht
- Subjects
pneumococcal colonisation ,pediatrics ,respiratory syncytial virus ,bronchiolitis ,immunity - Abstract
Since its discovery 60 years ago, we have greatly improved our knowledge of RSV disease. Many risk factors for development of serious disease have been identified that include prematurity, pre-existing medical conditions, in utero influences, and old age. There is no therapy and treatment remains supportive with oxygen and fluid maintenance. The majority of infants hospitalized with RSV bronchiolitis were previously healthy. Understanding why these children develop severe RSV bronchiolitis, whereas others only have mild RSV infection, is the main object of this doctoral thesis. The greatest independent risk factor for developing serious disease is young age. Waning maternal antibodies and the ability of RSV to evade systemic immunity offers some explanation, but there is increasing evidence supporting immune mediated pathology to RSV. Approximately 20% of association with severe disease can be accounted to polymorphisms in genes regulating early immune responses. Interestingly, children with almost absent immunity, such as those undergoing stem cell transplantation, do not necessarily show progression to severe disease in case of RSV infection. The development of severe RSV bronchiolitis is associated with a more robust cascade of pro-inflammatory responses displayed by higher levels of nasopharyngeal cytokines such as IL-6. Furthermore, there is a unique pattern of increased local IL-17 production during the convalescent phase of bronchiolitis This observation suggests a critical role for the epithelium as the first line of defense against RSV and is in accordance with the hypothesis of immune mediated pathology. There is an association between the IL1RL1 gene and RSV disease severity. The newly found genetic link, in light of the well established link between IL1RL1 and asthma, makes it an interesting candidate for future research on association with disease severity and post-bronchiolitis complications. The cascade of immune responses may exert effects beyond RSV. Young infants clear colonizing pneumococci from the nasopharynx during the course of bronchiolitis. It is crucial to study the fluctuations in non-invasive bacterial colonization of the nasopharynx that occur during childhood in relation to viral infection and to recognize the complex dynamics of microbial communities in the upper respiratory tract, especially in the development and evaluation of candidate viral vaccines.
- Published
- 2017
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