Search

Your search keyword '"Bondoux D"' showing total 73 results
Start Over Author "Bondoux D"
73 results on '"Bondoux D"'

2. Design and construction of a Cherenkov imager for charge measurement of nuclear cosmic rays

Author

Bourrion, O., Bernard, Ch., Bondoux, D., Bouly, J. L., Bouvier, J., Boyer, B., Brinet, M., Buenerd, M., Damieux, G., Derome, L., Eraud, L., Foglio, R., Fombaron, D., Grondin, D., Lee, M. H., Lutz, L., Marton, M., Menchaca-Rocha, A., Pelissier, A., Périé, J. N., Putze, A., Roudier, S., Sallaz-Damaz, Y., Seo, E. S., Scordilis, J. P., and Yoon, Y. S.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

A proximity focusing Cherenkov imager called CHERCAM, has been built for the charge measurement of nuclear cosmic rays with the CREAM instrument. It consists of a silica aerogel radiator plane across from a detector plane equipped with 1,600 1" diameter photomultipliers. The two planes are separated by a ring expansion gap. The Cherenkov light yield is proportional to the charge squared of the incident particle. The expected relative light collection accuracy is in the few percents range. It leads to an expected single element separation over the range of nuclear charge Z of main interest 1 < Z < 26. CHERCAM is designed to fly with the CREAM balloon experiment. The design of the instrument and the implemented technical solutions allowing its safe operation in high altitude conditions (radiations, low pressure, cold) are presented., Comment: 24 pages, 19 figures

Published
2011
Full Text
View/download PDF

3. Experimental study of a liquid Xenon PET prototype module

Author

Gallin-Martel, M. -L., Martin, P., Mayet, F., Ballon, J., Barbier, G., Barnoux, C., Berger, J., Bondoux, D., Bourrion, O., Collot, J., Dzahini, D., Foglio, R., Gallin-Martel, L., Garrigue, A., Jan, S., Petit, P., Stassi, P., Vezzu, F., and Tournefier, E.

Subjects
Physics - Medical Physics
Abstract

A detector using liquid Xenon in the scintillation mode is studied for Positron Emission Tomography (PET). The specific design aims at taking full advantage of the liquid Xenon properties. It does feature a promising insensitive to any parallax effect. This work reports on the performances of the first LXe prototype module, equipped with a position sensitive PMT operating in the VUV range (178 nm)., Comment: Proc. of the 7th International Workshops on Radiation Imaging Detectors (IWORID-7), Grenoble, France 4-7 July 2005

Published
2005
Full Text
View/download PDF

6. Towards the first beams from the ADIGE injector for the SPES Project

Author

Galatà, A, primary, Roncolato, C, additional, Bisoffi, G, additional, Francescon, P, additional, Bellan, L, additional, Bermudez, J, additional, Bortolato, D, additional, Comunian, M, additional, Conte, A, additional, De Lazzari, M, additional, Gelain, F, additional, Marcato, D, additional, Miglioranza, M, additional, Moisio, M F, additional, Munaron, E, additional, Pavinato, S, additional, Pedretti, D, additional, Pisent, A, additional, Rossignoli, M, additional, Roetta, M, additional, Savarese, G, additional, Bellato, M, additional, Angot, J, additional, Bondoux, D, additional, Thuillier, T, additional, and Andreev, V., additional

Published
2019
Full Text
View/download PDF

7. Characterization and Purification of the Serotonin Transporter Located at the Cytoplasmic Membrane of Human Platelets: A Three-step Strategy

Author

Launay, J.M., primary, Chopin-Robert, C., additional, Geoffroy, C., additional, Bondoux, D., additional, Lamblin, D., additional, Giron, M.L., additional, Mutel, V., additional, Buc-Caron, M.H., additional, Lasneret, L., additional, Kellermann, O., additional, Prada, M.Da, additional, and Alouf, J.E., additional

Published
1991
Full Text
View/download PDF

8. The MYRRHA LEBT commissioning and space charge compensation experiments

Author

Bouly, F., Bondoux, D., Belmans, J., Vandeplassche, D., Chauvin, N., Gérardin, F., Vernay, Emmanuelle, Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), and Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])

Subjects
[PHYS.PHYS.PHYS-ACC-PH]Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph], [PHYS.PHYS.PHYS-ACC-PH] Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2017

9. Prospect for a 60 GHz multicharged ECR ion source

Author

Thuillier, T., primary, Bondoux, D., additional, Angot, J., additional, Baylac, M., additional, Froidefond, E., additional, Jacob, J., additional, Lamy, T., additional, Leduc, A., additional, Sole, P., additional, Debray, F., additional, Trophime, C., additional, Skalyga, V., additional, and Izotov, I., additional

Published
2018
Full Text
View/download PDF

11. The low energy beam transport line for the MYRRHA accelerator

Author

Bouly, F., Bondoux, D., Baylac, M., Belmans, J., Jean-Luc BIARROTTE, Cabanel, T., Chauvin, N., Faure, R., Froidefond, E., Gérardin, F., Gomez-Martinez, Y., Labussière, E., Medeiros Romão, L., Migliore, M., Poyet, A., Rey, S., Uriot, D., Vandeplassche, D., Zimmermann, O., Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Centre d'Etude de l'Energie Nucléaire (SCK-CEN), Institut de Physique Nucléaire d'Orsay (IPNO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Vernay, Emmanuelle, and Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[PHYS.PHYS.PHYS-ACC-PH]Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph], [PHYS.PHYS.PHYS-ACC-PH] Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph]
Abstract

International audience; The MYRRHA Project aims at the construction of a new research reactor in Mol (Belgium) todemonstrate the transmutation feasibility with an accelerator-driven system (ADS). In its subcriticalconfiguration, the MYRRHA facility requires a proton flux with a maximum power of 2.4 MW(600 MeV – 4 mA). Such a continuous wave (CW) beam will be delivered by a superconducting linearaccelerator (linac) which must fulfil very stringent reliability requirements to ensure the safe ADSoperation with a high level of availability. The proton beam will be injected in the superconductinglinac with an energy of 17 MeV. The injector will enable to condition and pre-accelerate the protonbeam from 30 keV to 17 MeV. The injector is composed of: the proton source, the low-energy beamtransport line (LEBT), the Radio-frequency quadrupole (RFQ), and a series of CH-DTL cavities. Due tothe very-high reliability requirements it is absolutely necessary to carry out prototyping of all theelements of the accelerator in order to optimise its operation. In this purpose a LEBT prototype hasbeen built and is presently installed and operated at LPSC Grenoble (France). An experimentalprogramme to optimise the tuning of the line, the beam transport and to study the space-chargecompensation mechanism, is in progress. Once the line is commissioned it will be moved to Louvainla-Neuve (Belgium) to be coupled with the RFQ. We here review the construction and thecommissioning of the LEBT. Some experimental results are discussed, in particular the observedspace-charge compensation effects.

Published
2016

12. Le projet PIM : mesures de profil et d'intensité pour les lignes basses énergie

Author

Bouly, F., Bondoux, D., Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Centre National de la Recherche Scientifique (CNRS), and Vernay, Emmanuelle

Subjects
[PHYS.PHYS.PHYS-ACC-PH]Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph], [PHYS.PHYS.PHYS-ACC-PH] Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2016

13. Operation of the versatile accelerator driving the low power ADS GUINEVERE at SCK.CEN

Author

Baylac, M., Billebaud, A., Boge, P., Bondoux, D., Bouvier, J., Chabod, S., Dargaud, G., Froidefond, E., Labussière, E., Micoud, R., Rey, S., Kochetkov, A., Mertens, J., Gestel, F., Grieken, C., Houdt, B., Vittiglio, G., Lecolley, F. R., Lecouey, J. L., Lehaut, G., Nathalie Marie, Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), and Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)

Subjects
[PHYS.PHYS.PHYS-ACC-PH]Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph]
Abstract

TUPOL07; International audience;

Published
2014

14. Design progress of the MYRRHA Low Energy Beam Line

Author

Salemme, R., Medeiros Romão, L., Vandeplassche, D., Uriot, D., Jean-Luc BIARROTTE, Baylac, M., Bondoux, D., Bouly, F., Conto, J. M., Froidefond, E., Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), and Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[PHYS.PHYS.PHYS-ACC-PH]Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph]
Abstract

MOPP137; International audience;

Published
2014

16. Operation of the GENEPI-3C accelerator for the ADS mock-up GUINEVERE

Author

Froidefond, E., Baylac, M., Billebaud, A., Boge, P., Bondoux, D., Bouvier, J., Cabanel, T., Chabod, S., Dargaud, G., Heusch, M., Kochetkov, A., Labussière, E., Lecolley, F. R., Lecouey, J. L., Lehaut, G., Nathalie Marie, Mertens, J., Micoud, R., Gestel, F., Grieken, C., Houdt, B., Vittiglio, G., Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), and Vernay, Emmanuelle

Subjects
[PHYS.PHYS.PHYS-ACC-PH]Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph], [PHYS.PHYS.PHYS-ACC-PH] Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph]
Abstract

SCK-CEN (2014) ISBN 9781629938288; International audience

Published
2013

17. Operation of the accelerator driving the VENUS-F core for the low power ADS experiments Guinevere and FREYA at SCK-CEN

Author

Baylac, M., Billebaud, A., Boge, P., Bondoux, D., Bouvier, J., Cabanel, T., Chabod, S., Dargaud, G., Froidefond, E., Heusch, M., Kochetkov, A., Labussière, E., Lecolley, F. R., Lecouey, J. L., Lehaut, G., Nathalie Marie, Mertens, J., Micoud, R., Gestel, F., Grieken, C., Houdt, B., Vittiglio, G., Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), and Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)

Subjects
[PHYS.PHYS.PHYS-ACC-PH]Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph]
Abstract

International audience; GUINEVERE and FREYA are European projects devoted to experimental studies ofaccelerator-driven system feasibility. They are mainly dedicated to on-line reactivitymonitoring, subcriticality determination and operational procedures. An experimentalreactor of SCK•CEN (Belgium) modified into a fast lead core, VENUS-F, is coupled to aversatile accelerator-driven neutron source developed by CNRS/IN2P3 (France) driving thereactor in different modes. A deuteron beam is provided by an electrostatic acceleratorwith a time structure driven solely by the ion source. The deuteron ions are accelerated(220 keV) onto a tritiated target located at the centre of the reactor core, creating neutronsby T(d,n) 4 He reactions. This paper describes the design and commissioning of the facilityand reports on the operation of the accelerator coupled to the reactor.

Published
2013

18. A versatile neutron source for the low ADS GUINEVERE

Author

Baylac, Maud, Aït Abderrahim, H., Baeten, P., Bard, Pb., Billebaud, A., Bergmans, G., Boge, P., Bondoux, D., Bouvier, J., Buisson, R., Cabanel, T., Carcagno, Y., Damieux, G., Dargaud, G., de Conto, J.M., Desrues, P., Froidefond, E., Gaudiot, G., Gautier, J.M., Gómez-Martinez, Y., Granget, G., Heitz, G., Heusch, M., Kocher, H., Laune, B., Marchand, D., Mellier, F., Menu, Y., Merrer, Y., Micoud, R., Perbet, E., Planet, M., Poussot, P., Reynet, D., Ruescas, C., Scordilis, J.P., Schwaab, C., Tourrès, D., Vandeplassche, D., Vermeersch, F., Vittiglio, G., Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Département Recherches Subatomiques (DRS-IPHC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), GUINEVERE, Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), and Vernay, Emmanuelle

Subjects
[PHYS.PHYS.PHYS-ACC-PH]Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph], [PHYS.PHYS.PHYS-ACC-PH] Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2011

19. Some highlights of experimental ADS programs in Europe

Author

Baylac, M., Aït Abderrahim, H., Baeten, P., Ban, G., Bergmans, G., Billebaud, A., Bondoux, D., Bouvier, J., Chabod, S., Conto, J. M., Dessagne, P., Froidefond, E., Gaudiot, G., Gautier, J. M., Granget, G., Heitz, G., Kerveno, M., Kochetkov, A., Laune, B., Lecolley, F. R., Lecouey, J. L., Nathalie Marie, Mellier, F., Merrer, Y., Nuttin, A., Reynet, D., Steckmeyer, J. C., Uyttenhove, W., Vandeplassche, D., Vermeersch, F., Vittiglio, G., Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) (CEA-DES (ex-DEN)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), GUINEVERE, Vernay, Emmanuelle, Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), and Normandie Université (NU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[PHYS.PHYS.PHYS-ACC-PH]Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph], [PHYS.PHYS.PHYS-ACC-PH] Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2010

20. The Guinevere project at the VENUS-F Facility

Author

Baeten, P., Ait Abderrahim, H., Bergmans, G., Kochetkov, A., Uyttenhove, W., Vandeplassche, D., Vermeersch, F., Vittiglio, G., Ban, G., Baylac, M., Billebaud, A., Bondoux, D., Bouvier, J., Chabod, S., Conto, J. M., Dessagne, P., Gaudiot, G., Gautier, J. M., Heitz, G., Kerveno, M., Laune, B., Lecouey, J. L., Lecolley, F. R., Nathalie Marie, Merrer, Y., Nuttin, A., Reynet, D., Steckmeyer, J. C., Mellier, F., Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) (CEA-DES (ex-DEN)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), GUINEVERE, Normandie Université (NU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[PHYS.PHYS.PHYS-ACC-PH]Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph], [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), ComputingMilieux_MISCELLANEOUS
Abstract

https://www.euronuclear.org/events/enc/enc2010/transactions/ENC2010-transactions-wed.pdf; International audience

Published
2010

21. GENEPI-3C, a versatile neutron generator for the GUINEVERE ADS feasibility studies

Author

De Conto, J.M., Baylac, M., Billebaud, A., Boge, P., Bondoux, D., Bouvier, J., Cabanel, T., Carcagno, Y., Dargaud, G., Froidefond, E., Gomez Martinez, Y., Heusch, M., Marchand, D., Micoud, R., Perbet, E., Planet, M., Tourres, D., Beaten, P., Vittiglio, G., Gaudiot, G., Heitz, G., Poussot, P., Ruescas, C., Gautier, J.M., Merrer, Y., Granget, G., Mellier, F., Laune, J., Reynet, D., Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Institut Pluridisciplinaire Hubert Curien (IPHC), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), and Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11)

Subjects
[PHYS.PHYS.PHYS-ACC-PH]Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph]
Abstract

TU6PFP028; International audience; GUINEVERE, Generator-of-Uninterrupted- Intense-NEutrons-at-the-lead-VEnus-REactor, is devoted to ADS feasibility studies and to investigate on-line reactivity monitoring, sub-criticality determination and operational procedures. It will couple a versatile neutron source to the VENUS-F lead core at the SCK*CEN site in Mol (Belgium). It is based on an electrostatic accelerator generating 14 MeV neutrons by bombarding a deuteron beam on a tritium target located in the reactor core. A new accelerator has been developed. It will produce alternatively 1 μs 250 keV deuteron pulses with adjustable repetition rate (40 mA peak), as well as continuous beam (1 mA) with programmable interruptions. Beam will be inserted vertically into the reactor core. The accelerator is designed to enable the vertical section of the beam line to be easily lifted out the reactor bunker for maintenance operations, target changes and core loading procedures. This paper will describe the design of the accelerator and its commissioning in Grenoble (France), before its transfer to the Belgian site. This work is performed within the 6th Framework Program EC project EUROTRANS.GUINEVERE, Generator-of-Uninterrupted- Intense-NEutrons-at-the-lead-VEnus-REactor, is devoted to ADS feasibility studies and to investigate on-line reactivity monitoring, sub-criticality determination and operational procedures. It will couple a versatile neutron source to the VENUS-F lead core at the SCK*CEN site in Mol (Belgium). It is based on an electrostatic accelerator generating 14 MeV neutrons by bombarding a deuteron beam on a tritium target located in the reactor core. A new accelerator has been developed. It will produce alternatively 1 μs 250 keV deuteron pulses with adjustable repetition rate (40 mA peak), as well as continuous beam (1 mA) with programmable interruptions. Beam will be inserted vertically into the reactor core. The accelerator is designed to enable the vertical section of the beam line to be easily lifted out the reactor bunker for maintenance operations, target changes and core loading procedures. This paper will describe the design of the accelerator and its commissioning in Grenoble (France), before its transfer to the Belgian site. This work is performed within the 6th Framework Program EC project EUROTRANS.

Published
2009

22. The GENEPI-3C Accelerator for the GUINEVERE Project

Author

Baylac, M., Aıt Abderrahim, H., Baeten, P., Billebaud, A., Bergmans, G., Boge, P., Bondoux, D., Bouvier, J., Cabanel, T., Carcagno, Y., Dargaud, G., De Conto, J.M., Gaudiot, G., Gautier, J.M., Gomez Martinez, Y., Granget, G., Heitz, G., Heusch, M., Laune, B., Marchand, D., Mellier, F., Merrer, Y., Micoud, R., Perbet, E., Planet, M., Poussot, P., Reynet, D., Ruescas, C., Tourrès, D., Vermeersch, F., Vittiglio, G., Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Institut Pluridisciplinaire Hubert Curien (IPHC), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), GUINEVERE, Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), and Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11)

Subjects
[PHYS.PHYS.PHYS-ACC-PH]Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph]
Abstract

Proc. CD Series IAEA-13-CN-173 ISBN 9789201504104; International audience; GUINEVERE, Generator-of-Uninterrupted-Intense-NEutrons-at-the-lead-VEnus-REactor, is a project of the Domain 2 of the FP6 EUROTRANS Integrated Project devoted to Accelerator Driven System (ADS) feasibility studies. Domain 2, ECATS, is related to specific Experiments for Coupling an Accelerator, a Target and a Subcritical core. GUINEVERE will investigate on-line reactivity monitoring, sub-criticality determination and operational procedures in an ADS. The project consists in coupling a modified VENUS facility at the SCK-CEN site in Mol (Belgium) to an upgraded GENEPI neutron source. SCK-CEN is transforming the water moderated VENUS reactor into a fast lead core facility, the fuel and lead rodlets being provided by CEA. The GEnerator-of-NEutrons-Pulsed-and-Intense is an electrostatic accelerator generating 14 MeV neutrons by bombarding a high intensity deuteron beam on a tritium target located in the reactor core. CNRS is designing and building a new accelerator, GENEPI-3C, to meet the new requirements of the experimental program: it will be capable of delivering alternatively 1 μs long deuteron pulses with adjustable repetition rate, as well as continuous beam with programmable interruptions. This paper will describe the design and commissioning of the GENEPI accelerator

Published
2009

23. GUINEVERE: Construction of a Zero-Power Pb ADS at Mol

Author

Billebaud, A., Baeten, P., Aït Abderrahim, H., Ban, G., Baylac, M., Bergmans, G., Bondoux, D., Bouvier, J., Chabod, S., Conto, J. M., Dessagne, P., Gaudiot, G., Gautier, J. M., Granget, G., Heitz, G., Kerveno, M., Kochetkov, A., Laune, B., Lecolley, F. R., Lecouey, J. L., Nathalie Marie, Mellier, F., Merrer, Y., Nuttin, A., Reynet, D., Steckmeyer, J. C., Vandeplassche, D., Vermeersch, F., Vittiglio, G., Vernay, Emmanuelle, Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), and GUINEVERE

Subjects
[PHYS.PHYS.PHYS-ACC-PH]Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph], [PHYS.PHYS.PHYS-ACC-PH] Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph]
Abstract

International audience; The GUINEVERE project is running since 2007 and is part of the EUROTRANS Integrated Project of the 6th EURATOM Framework Programme. It consists first in the construction of a lead fast ADS mock-up at SCK-CEN Mol (Belgium) for the purpose of ADS subcriticality monitoring experiments, and beyond in support to the design of a Transmutation Experimental Facility (MYRRHA/FASTEF). To do so the VENUS reactor (SCK-CEN) will be coupled with a new GENEPI neutron source under construction by CNRS (France). To accommodate this new source (a 250 keV deuteron accelerator) in a vertical coupling configuration, the VENUS building is being heightened. In parallel the reactor core is being modified to be loaded with fuel assemblies made of enriched Uranium and solid Lead moderator pins, and hold radial and axial Lead reflectors. A new safety and control rod system is also under development. The new GENEPI-3C neutron source is designed to be operated in pulsed mode but also in continuous mode to investigate the current-to-flux reactivity indicator in representative conditions of a powerful ADS. In this latter mode it will be also possible to make short beam interruptions at a fixed frequency to have access to the neutron population decrease as a function of time. The vertical beam line will have the distinctive feature to be retractile, allowing target changing or complete removal (for critical configuration for example). The accelerator will be first completely assembled at LPSC Grenoble for beam characterization before to be transferred in Mol. We will present in this paper the status of this experimental facility assembling, and foreseen experimental programmes in the framework of fast transmutation system studies.

Published
2009

24. The GUINEVERE Project for Accelerator Driven System Physics

Author

Billebaud, A., Baeten, P., Aït Abderrahim, H., Ban, G., Baylac, M., Bergmans, G., Bondoux, D., Bouvier, J., Chabod, S., Conto, J. M., Dessagne, P., Gaudiot, G., Gautier, J. M., Granget, G., Heitz, G., Kerveno, M., Kochetkov, A., Laune, B., Lecolley, F. R., Lecouey, J. L., Nathalie Marie, Mellier, F., Merrer, Y., Nuttin, A., Reynet, D., Steckmeyer, J. C., Uyttenhove, W., Vandeplassche, D., Vermeersch, F., Vittiglio, G., Vernay, Emmanuelle, Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), and Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)

Subjects
[PHYS.PHYS.PHYS-ACC-PH]Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph], [PHYS.PHYS.PHYS-ACC-PH] Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph]
Abstract

paper 9414; International audience; The GUINEVERE project is part of the EUROTRANS Integrated Project of the 6th EURATOM Framework Programme. It is mainly devoted to ADS on-line reactivity monitoring validation, sub-criticality determination and operational procedures (loading, start-up, shut-down, ...) as a follow-up of the MUSE experiments. The project consists in coupling a fast lead core, set-up in the VENUS reactor at SCK*CEN Mol (B), with a GENEPI neutron source under construction by CNRS. To accommodate the accelerator in a vertical coupling configuration, the VENUS building is being heightened. The fast core will be loaded with enriched Uranium and will be moderated and reflected with solid lead (zero power experiment). For the purpose of the experimental programme, the neutron source has to be operated not only in pulsed mode but also in continuous mode to investigate the current-to-flux reactivity indicator in representative conditions of a powerful ADS. In this latter mode it is also required to make short beam interruptions to have access to the neutron population decrease as a function of time: from this spectrum it will be possible to apply different analysis techniques such as "prompt decay" fitting techniques and "source jerk" techniques. Beam interruptions will be repeated at a programmable frequency to improve time spectra statistics. Different sub-criticality levels (keff=0.99, 0.97, 0.95, ...) will be investigated in order to obtain a full set of data points for the final overall validation of the methodology. This paper describes the status of the experimental facility assembling, and the foreseen experimental programme to be started.

Published
2009

25. The GUINEVERE project at the VENUS facility

Author

Baeten, P., Aït Abderrahim, H., Aoust, T., Bergmans, G., Heyse, J., Maes, D., Verboomen, B., Vermeersch, F., Vittiglio, G., Ban, G., Baylac, M., Billebaud, A., Bondoux, D., Bouvier, J., Conto, J. M., Dessagne, P., Gaudiot, G., Gautier, J. M., Grondin, D., Heitz, G., Kerveno, M., Laune, B., Lecolley, F. R., Lecouey, J. L., Marchand, D., Nathalie Marie, Merrer, Y., Micoud, R., Planet, M., Reynet, D., Ruescas, C., Steckmeyer, J. C., Granget, G., Mellier, F., Rimpault, G., Centre d'Etude de l'Energie Nucléaire (SCK-CEN), Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Institut Pluridisciplinaire Hubert Curien (IPHC), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) (CEA-DES (ex-DEN)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Normandie Université (NU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)

Subjects
[PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], ComputingMilieux_MISCELLANEOUS
Abstract

Proc. on CD Rom log315; International audience; The GUINEVERE project is an international project in the framework of IP-EUROTRANS, the FP6 program which aims at addressing the main issues for ADS development in the framework of partitioning and transmutation for nuclear waste volume and radiotoxicity reduction. The GUINEVERE project is carried out in the context of domain 2 of IP-EUROTRANS, ECATS, devoted to specific experiments for the coupling of an accelerator, a target and a subcritical core. These experiments should provide an answer to the questions of online reactivity monitoring, sub-criticality determination and operational procedures (loading, start-up, shutdown, …) in an ADS by 2009-2010. The project has the objective to couple a fast lead core, within the VENUS building operated by the SCK•CEN, with a neutron generator able to work in three different modes: pulsed, continuous and continuous with beam interruptions at the millisecond scale. In order to achieve this goal, the VENUS facility has to be adapted and a modified GENEPI-3C accelerator has to be designed and constructed. The paper describes the main modifications to the reactor core and facility and to the accelerator, which will be executed during the years 2008 and 2009, and the experimental programme which will start in 2009.

Published
2008

26. Theoretical study and experimental result of the RF coupler prototypes of Spiral2

Author

Gomez Martinez, Y., Bondoux, D., Carretta, J.M., de Conto, J.M., Fruneau, M., Garrigue, A., Marchand, D., Micoud, R., Vernay, E., Vezzu, F., Di Giacomo, M., Balleyguier, P., Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Grand Accélérateur National d'Ions Lourds (GANIL), Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), SPIRAL2, bibliotheque, LPSC, Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[PHYS.PHYS.PHYS-ACC-PH]Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph], [PHYS.PHYS.PHYS-ACC-PH] Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph]
Abstract

JACoW web site THPCH160; International audience; Spiral2 is a 40 MeV-5mA deuterons and a 14.5 MeV/u-1mA heavy ions superconducting linac under construction at GANIL. The RF couplers have to provide 12 kW CW power to the cavities at 88 MHz for an accelerating field of 6.5 MV/m. Two solutions corresponding to two different technologies have been designed and two prototypes have been built. We present the technical proposals ans issues as well as the results (manufacturing, test at low and high power, multipacting...) leading to the final choice.

Published
2006

27. IPHI - Irradiations de l'arrêt faisceau en nickel par des protons de 3 MeV

Author

Bondoux, D., Brissot, R., Fruneau, M., Marchand, D., Pinston, J.A., Vernay, E., Olivier, A., Gardes, D., Magistris, M., Million, S., Sauvage, T., Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), European Organization for Nuclear Research (CERN), Institut Laue-Langevin (ILL), and ILL

Subjects
[PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex]
Published
2005

28. Design and construction of a Cherenkov imager for charge measurement of nuclear cosmic rays

Author

Bourrion, O, primary, Bernard, C, additional, Bondoux, D, additional, Bouly, J L, additional, Bouvier, J, additional, Boyer, B, additional, Brinet, M, additional, Buenerd, M, additional, Damieux, G, additional, Derome, L, additional, Eraud, L, additional, Foglio, R, additional, Fombaron, D, additional, Grondin, D, additional, Lee, M H, additional, Lutz, L, additional, Marton, M, additional, Menchaca-Rocha, A, additional, Pelissier, A, additional, Périé, J N, additional, Putze, A, additional, Roudier, S, additional, Sallaz-Damaz, Y, additional, Seo, E S, additional, Scordilis, J P, additional, and Yoon, Y S, additional

Published
2011
Full Text
View/download PDF

29. [Opiate hypothesis in infantile autism? Therapeutic trials with naltrexone]

Author

Marion LEBOYER, Mp, Bouvard, Jm, Launay, Recasens C, Mh, Plumet, Waller-Perotte D, Tabuteau F, Bondoux D, and Dugas M

Subjects
Male, Adolescent, Dose-Response Relationship, Drug, Double-Blind Method, Child, Preschool, Receptors, Opioid, Animals, Humans, Female, Endorphins, Autistic Disorder, Child, Naltrexone
Abstract

The opioid hypothesis suggests that childhood autism may result from excessive brain opioid activity during neonatal period which may constitutionally inhibit social motivation, yielding autistic isolation and aloofness (Panksepp, 1979). This hypothesis has now received strong support and is currently based on three types of arguments: (1) similarity between autistic symptomatology and abnormal behaviors induced in young animals by injections of exogenous opioids, such as increasing social aloofness and decreasing social vocalization; (2) direct biochemical evidence of abnormalities of peripheral endogenous opioids being reported in autism and (3) therapeutic effects of the long lasting opioid receptor blocking agent naltrexone in autism. In this article, we give description of open and double-blind studies of naltrexone in autism. Naltrexone has been tested in several open studies. We performed an open trial with naltrexone in 2 autistic girls, displaying serious self-injurious behavior, reduced crying and a marked preference for salty and spicy foods, symptoms that could be related to a dysfunction of the opioid system. With dosages of 1 mg/kg/day, we observed an immediate reduction of hyperactivity, self-injurious behavior and aggressiveness, while attention improved. In addition, social behaviors, smiling, social seeking behaviors and play interactions increased (Leboyer, Bouvard et Dugas, 1988). Campbell et al. (1988) has also reported a tranquilizing and a stimulating effect in 6 out of 8 children with autism. We did confirm these preliminary results in a double-blind study performed on 4 children with autism. In a cross-over double-blind study, three dosages of naltrexone (0.5, 1 and 2 mg/kg/day) and placebo were compared.(ABSTRACT TRUNCATED AT 250 WORDS)

Published
1993

39. Ras involvement in signal transduction by the serotonin 5-HT2B receptor.

Author

Launay, J M, Birraux, G, Bondoux, D, Callebert, J, Choi, D S, Loric, S, and Maroteaux, L

Abstract

The family of serotonin 5-HT2 receptors stimulates the phospholipase C second messenger pathway via the alpha subunit of the Gq GTP-binding protein. Here, we show that agonist stimulation of the 5-HT2B receptor subtype stably expressed in the mouse fibroblast LMTK- cell line causes a rapid and transient activation of the proto-oncogene product p21ras as measured by an increase in GTP-bound Ras in response to serotonin. Furthermore, 5-HT2B receptor stimulation activates p42mapk/p44mapk (ERK2/ERK1) mitogen-activated protein kinases as assayed by phosphorylation of myelin basic protein. Antibodies against p21ras, Galphaq, -beta, or -gamma2 subunits of the GTP-binding protein inhibit MAP kinase-dependent phosphorylation. The MAP kinase activation is correlated with a stimulation of cell division by serotonin. In addition to this mitogenic action, transforming activity of serotonin is mediated by the 5-HT2B receptor since its expression in LMTK- cells is absolutely required for foci formation and for these foci to form tumors in nude mice. Finally, we detected expression of the 5-HT2B receptor in spontaneous human and Mastomys natalensis carcinoid tumors and, similar to the 5-HT2B receptor transfected cells, the Mastomys tumor cells are also responsive to serotonin with similar coupling to p21ras activation.

Published
1996

40. Étude du comportement dynamique d'un prototype de pompe diphasique

Author

Bou-Saïd, Benyebka, Bondoux, D., Ferraris, G., Lalanne, M., Laboratoire de Mécanique des Contacts et des Structures [Villeurbanne] (LaMCoS), Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), and Bou-Saïd, Benyebka

Subjects
[PHYS.MECA.GEME] Physics [physics]/Mechanics [physics]/Mechanical engineering [physics.class-ph], [PHYS.MECA.GEME]Physics [physics]/Mechanics [physics]/Mechanical engineering [physics.class-ph], [SPI.MECA.GEME] Engineering Sciences [physics]/Mechanics [physics.med-ph]/Mechanical engineering [physics.class-ph], ComputingMilieux_MISCELLANEOUS, [SPI.MECA.GEME]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Mechanical engineering [physics.class-ph]
Abstract

International audience

Published
1986

41. Serotonin receptors and therapeutics

Author

Jm, Launay, Callebert J, Bondoux D, Loric S, and Luc Maroteaux

Subjects
Serotonin, Molecular Structure, Vomiting, Mental Disorders, Migraine Disorders, Antidepressive Agents, Ion Channels, Rats, Serotonin Receptor Agonists, Mice, Structure-Activity Relationship, Dogs, Anti-Anxiety Agents, Cricetinae, Receptors, Serotonin, Cyclic AMP, Animals, Antiemetics, Humans, Drosophila, Serotonin Antagonists, Selective Serotonin Reuptake Inhibitors, Signal Transduction
Abstract

Since its discovery, serotonin (5-hydroxytryptamine = 5-HT) has become a major player on the neurotransmitter "stage". Multiple receptor subtypes for 5-HT have been identified and classified, and a vast pharmacology of 5-HT has emerged. In particular, 5-HT has been shown to exert marked effects on the cardiovascular system, central nervous system (CNS) and gastrointestinal (GI) tract, and important ligands have been developed that mimic or block its action selectively. Furthermore, drugs that release 5-HT, and others that prevent its uptake, have been developed. This brief review focuses on the pharmacology of 5-HT agonists and antagonists that exhibit, at least partly, clinical relevance.

44. Chromosomes 4 and 13 in beta-carboline-induced seizures in mice: benzodiazepine binding.

Author

Clément Y, Martin B, Bondoux D, Venault P, Launay JM, and Chapouthier G

Subjects
Animals, Brain drug effects, Flumazenil pharmacokinetics, Mice, Mice, Inbred Strains, Mice, Mutant Strains, Radioligand Assay, Receptors, GABA-A drug effects, Seizures chemically induced, Seizures physiopathology, Species Specificity, Tritium, Brain metabolism, Carbolines pharmacology, Chromosome Mapping, Convulsants pharmacology, Receptors, GABA-A physiology, Seizures genetics
Abstract

Methyl beta-carboline-3-carboxylate (beta-CCM) is a ligand for the benzodiazepine (BZD) binding site of the GABA-A receptors with convulsive properties. We provided evidence for the involvement of a fragment of mouse chromosomes 4 and 13 in beta-CCM-induced seizures in a previous paper. Here, we analyzed, through [3H]-flumazenil binding, whether central BZD binding sites could be involved in the physiological processes underlying these differences of genetic sensitivities. In the JE/Le strain, where the effects of the chromosome 4 fragment can be analyzed, we found associations between [3H]-flumazenil binding and the convulsive action of beta-CCM. On the contrary, this no longer holds true in C3XtEso strain, where the effects of the chromosome 13 fragment were observed.

Published
2000
Full Text
View/download PDF

45. A mouse mutant strain highly resistant to methyl beta-carboline-3-carboxylate-induced seizures.

Author

Clément Y, Launay JM, Bondoux D, Venault P, Martin B, Young J, Robel P, and Chapouthier G

Subjects
Animals, Carbolines, Convulsants, Drug Resistance genetics, Evaluation Studies as Topic, Female, Male, Mice, Mice, Mutant Strains, Pentylenetetrazole, Radioligand Assay, Seizures chemically induced, Brain Chemistry physiology, Pregnanolone analysis, Pregnenolone analysis, Receptors, GABA-A analysis, Seizures genetics
Abstract

The convulsant properties of methyl beta-carboline-3-carboxylate (beta-CCM) were evaluated in the TaT-fm/GncTa+/+Tfm strain carrying the tabby coat color (Ta) and/or the testicular feminization (Tfm) gene. When injected intraperitoneally within a 5-60 mg/kg dose range, beta-CCM-induced convulsions in less than 25% of the mice, thus providing evidence for a high resistance of this strain, as compared to classical strains of mice. However, this strain responds normally to the convulsant pentylenetetrazol (PTZ), suggesting a specific resistance to beta-CCM. Both the Ta gene and the TaTfm/Gnc genetic background were involved in the high resistance to beta-CCM. In addition, concentrations of neurosteroids and benzodiazepine binding, both modulating GABAA receptor efficacy, have been measured in order to elucidate the biological mechanisms of drug resistance.

Published
1996
Full Text
View/download PDF

46. Low-dose naltrexone effects on plasma chemistries and clinical symptoms in autism: a double-blind, placebo-controlled study.

Author

Bouvard MP, Leboyer M, Launay JM, Recasens C, Plumet MH, Waller-Perotte D, Tabuteau F, Bondoux D, Dugas M, and Lensing P

Subjects
Adolescent, Autistic Disorder blood, Autistic Disorder psychology, Child, Child, Preschool, Dose-Response Relationship, Drug, Double-Blind Method, Drug Administration Schedule, Female, Humans, Male, Naltrexone adverse effects, Narcotic Antagonists adverse effects, Personality Assessment, Autistic Disorder drug therapy, Naltrexone administration & dosage, Narcotic Antagonists administration & dosage, Neurotransmitter Agents blood, beta-Endorphin blood
Abstract

The effect of month-long naltrexone (NTX) treatment at a daily oral dose of 0.5 mg/kg/day was contrasted with placebo (PLC) in a double-blind study with conjoint clinical and biochemical evaluations of therapeutic effects. Modest clinical benefits were achieved with both PLC and NTX, with marginally better overall results following NTX, and degree of improvement appeared to be related to plasma chemical profiles. Massively elevated levels of beta-endorphin were observed in all children with assays using C-terminal antibody but not with an N-terminal antibody assay. In addition, 70% of the children exhibited abnormally low levels of adrenocorticotropic hormone, and smaller subsets exhibited elevated norepinephrine (60%), arginine-vasopressin (50%), and serotonin (20%). The best clinical responders exhibited the clearest normalization of the elevated plasma chemistries, especially in C-terminal-beta-endorphin and serotonin. There was some evidence of therapeutic carry-over effects in both clinical and biochemical measures in those children who received NTX before PLC. The results suggest that NTX only benefits a subgroup of autistic children, who may be identified by the presence of certain plasma abnormalities. These results suggest a possible linkage between abnormal plasma chemistries, especially those related to the pro-opiomelanocortin system, and autistic symptoms.

Published
1995
Full Text
View/download PDF

47. Difference between plasma N- and C-terminally directed beta-endorphin immunoreactivity in infantile autism.

Author

Leboyer M, Bouvard MP, Recasens C, Philippe A, Guilloud-Bataille M, Bondoux D, Tabuteau F, Dugas M, Panksepp J, and Launay JM

Subjects
Adolescent, Adrenocorticotropic Hormone blood, Adult, Child, Child, Preschool, Dopamine blood, Dynorphins blood, Enkephalin, Leucine blood, Enkephalin, Methionine blood, Epinephrine blood, Female, Humans, Male, Norepinephrine blood, Opioid Peptides blood, Peptide Termination Factors, Pro-Opiomelanocortin genetics, Pro-Opiomelanocortin metabolism, Radioimmunoassay, Rett Syndrome blood, beta-Endorphin biosynthesis, beta-Endorphin genetics, Autistic Disorder blood, beta-Endorphin blood
Abstract

Objective: The authors investigated whether there is excessive opioid activity in infantile autism by measuring plasma beta-endorphin in patients with autism compared with patients who had Rett's syndrome and normal comparison subjects., Methods: Radioimmunoassays for beta-endorphin using C-terminally and N-terminally directed antisera were applied to plasma samples from 67 children who met both DSM-III-R and ICD-10 diagnostic criteria for infantile autism, 22 girls with Rett's syndrome, and 67 normal children matched in age and sex with the children with autism., Results: Median N-terminally directed beta-endorphin immunoreactivity appeared to be slightly lower in subjects with autism (7 pg/ml) and clearly higher in the girls with Rett's syndrome (40 pg/ml) than in the comparison subjects (9 pg/ml). Median C-terminally directed beta-endorphin immunoreactivity was higher in the girls with Rett's syndrome (35 pg/ml) and much higher in patients with autism (70 pg/ml) than in comparison subjects (8 pg/ml)., Conclusions: These findings demonstrate the existence of a wide discrepancy between C- and N-terminally directed beta-endorphin immunoreactivity among children with autism. Despite the fact that the nature of the antigen recognized in the plasma of autistic children by the C-terminally directed anti-beta-endorphin serum remains to be characterized, the difference between C- and N-terminally directed beta-endorphin immunoreactivity might suggest an abnormal processing of the pro-opiomelanocortin gene in infantile autism.

Published
1994
Full Text
View/download PDF

48. Serotonin receptors and therapeutics.

Author

Launay JM, Callebert J, Bondoux D, Loric S, and Maroteaux L

Subjects
Animals, Anti-Anxiety Agents therapeutic use, Antidepressive Agents therapeutic use, Antiemetics therapeutic use, Cricetinae, Cyclic AMP physiology, Dogs, Drosophila, Humans, Ion Channels drug effects, Mental Disorders physiopathology, Mice, Migraine Disorders drug therapy, Molecular Structure, Rats, Receptors, Serotonin classification, Receptors, Serotonin physiology, Serotonin Antagonists chemistry, Serotonin Antagonists classification, Serotonin Antagonists pharmacology, Serotonin Receptor Agonists chemistry, Serotonin Receptor Agonists classification, Serotonin Receptor Agonists pharmacology, Selective Serotonin Reuptake Inhibitors chemistry, Selective Serotonin Reuptake Inhibitors classification, Selective Serotonin Reuptake Inhibitors pharmacology, Signal Transduction, Structure-Activity Relationship, Vomiting drug therapy, Mental Disorders drug therapy, Receptors, Serotonin drug effects, Serotonin physiology, Serotonin Antagonists therapeutic use, Serotonin Receptor Agonists therapeutic use, Selective Serotonin Reuptake Inhibitors therapeutic use
Abstract

Since its discovery, serotonin (5-hydroxytryptamine = 5-HT) has become a major player on the neurotransmitter "stage". Multiple receptor subtypes for 5-HT have been identified and classified, and a vast pharmacology of 5-HT has emerged. In particular, 5-HT has been shown to exert marked effects on the cardiovascular system, central nervous system (CNS) and gastrointestinal (GI) tract, and important ligands have been developed that mimic or block its action selectively. Furthermore, drugs that release 5-HT, and others that prevent its uptake, have been developed. This brief review focuses on the pharmacology of 5-HT agonists and antagonists that exhibit, at least partly, clinical relevance.

Published
1994

49. [Opiate hypothesis in infantile autism? Therapeutic trials with naltrexone].

Author

Leboyer M, Bouvard MP, Launay JM, Recasens C, Plumet MH, Waller-Perotte D, Tabuteau F, Bondoux D, and Dugas M

Subjects
Adolescent, Animals, Autistic Disorder physiopathology, Autistic Disorder psychology, Child, Child, Preschool, Dose-Response Relationship, Drug, Double-Blind Method, Female, Humans, Male, Naltrexone adverse effects, Receptors, Opioid physiology, Autistic Disorder drug therapy, Endorphins physiology, Naltrexone administration & dosage, Receptors, Opioid drug effects
Abstract

The opioid hypothesis suggests that childhood autism may result from excessive brain opioid activity during neonatal period which may constitutionally inhibit social motivation, yielding autistic isolation and aloofness (Panksepp, 1979). This hypothesis has now received strong support and is currently based on three types of arguments: (1) similarity between autistic symptomatology and abnormal behaviors induced in young animals by injections of exogenous opioids, such as increasing social aloofness and decreasing social vocalization; (2) direct biochemical evidence of abnormalities of peripheral endogenous opioids being reported in autism and (3) therapeutic effects of the long lasting opioid receptor blocking agent naltrexone in autism. In this article, we give description of open and double-blind studies of naltrexone in autism. Naltrexone has been tested in several open studies. We performed an open trial with naltrexone in 2 autistic girls, displaying serious self-injurious behavior, reduced crying and a marked preference for salty and spicy foods, symptoms that could be related to a dysfunction of the opioid system. With dosages of 1 mg/kg/day, we observed an immediate reduction of hyperactivity, self-injurious behavior and aggressiveness, while attention improved. In addition, social behaviors, smiling, social seeking behaviors and play interactions increased (Leboyer, Bouvard et Dugas, 1988). Campbell et al. (1988) has also reported a tranquilizing and a stimulating effect in 6 out of 8 children with autism. We did confirm these preliminary results in a double-blind study performed on 4 children with autism. In a cross-over double-blind study, three dosages of naltrexone (0.5, 1 and 2 mg/kg/day) and placebo were compared.(ABSTRACT TRUNCATED AT 250 WORDS)

Published
1993

50. Genetic difference in sensitivity to beta-carboline: evidence for the involvement of brain benzodiazepine receptors.

Author

Chapouthier G, Bondoux D, Martin B, Desforges C, and Launay JM

Subjects
Animals, Clonazepam pharmacology, Kinetics, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Receptors, GABA-A drug effects, Seizures physiopathology, Species Specificity, Strychnine toxicity, Brain metabolism, Carbolines pharmacology, Convulsants pharmacology, Flunitrazepam metabolism, Receptors, GABA-A metabolism
Abstract

The convulsive effects of methyl beta-carboline-3-carboxylate (beta-CCM), a benzodiazepine receptor ligand, are different in two inbred strains of mice: BALB/cBy mice are more sensitive to beta-CCM than C57BL/6J mice. In the present article, we report the effects of [3H]flunitrazepam binding in these two strains, which suggest a possible explanation of the differences in their sensitivity to beta-CCM by the involvement of brain benzodiazepine receptors.

Published
1991
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results