Author: "Boncoraglio, Giorgio B" - Searchworks@Jio Institute Digital Library Search Results

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213 results on '"Boncoraglio, Giorgio B"'

1. Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting

Author: Chauhan, Ganesh, Adams, Hieab HH, Satizabal, Claudia L, Bis, Joshua C, Teumer, Alexander, Sargurupremraj, Muralidharan, Hofer, Edith, Trompet, Stella, Hilal, Saima, Smith, Albert Vernon, Jian, Xueqiu, Malik, Rainer, Traylor, Matthew, Pulit, Sara L, Amouyel, Philippe, Mazoyer, Bernard, Zhu, Yi-Cheng, Kaffashian, Sara, Schilling, Sabrina, Beecham, Gary W, Montine, Thomas J, Schellenberg, Gerard D, Kjartansson, Olafur, Guðnason, Vilmundur, Knopman, David S, Griswold, Michael E, Windham, B Gwen, Gottesman, Rebecca F, Mosley, Thomas H, Schmidt, Reinhold, Saba, Yasaman, Schmidt, Helena, Takeuchi, Fumihiko, Yamaguchi, Shuhei, Nabika, Toru, Kato, Norihiro, Rajan, Kumar B, Aggarwal, Neelum T, De Jager, Philip L, Evans, Denis A, Psaty, Bruce M, Rotter, Jerome I, Rice, Kenneth, Lopez, Oscar L, Liao, Jiemin, Chen, Christopher, Cheng, Ching-Yu, Wong, Tien Y, Ikram, Mohammad K, van der Lee, Sven J, Amin, Najaf, Chouraki, Vincent, DeStefano, Anita L, Aparicio, Hugo J, Romero, Jose R, Maillard, Pauline, DeCarli, Charles, Wardlaw, Joanna M, del C. Valdés Hernández, Maria, Luciano, Michelle, Liewald, David, Deary, Ian J, Starr, John M, Bastin, Mark E, Maniega, Susana Muñoz, Slagboom, P Eline, Beekman, Marian, Deelen, Joris, Uh, Hae-Won, Lemmens, Robin, Brodaty, Henry, Wright, Margaret J, Ames, David, Boncoraglio, Giorgio B, Hopewell, Jemma C, Beecham, Ashley H, Blanton, Susan H, Wright, Clinton B, Sacco, Ralph L, Wen, Wei, Thalamuthu, Anbupalam, Armstrong, Nicola J, Chong, Elizabeth, Schofield, Peter R, Kwok, John B, van der Grond, Jeroen, Stott, David J, Ford, Ian, Jukema, J Wouter, Vernooij, Meike W, Hofman, Albert, Uitterlinden, André G, van der Lugt, Aad, Wittfeld, Katharina, Grabe, Hans J, Hosten, Norbert, von Sarnowski, Bettina, Völker, Uwe, Levi, Christopher, and Jimenez-Conde, Jordi
Subjects: Biomedical and Clinical Sciences, Neurosciences, Clinical Sciences, Stroke, Brain Disorders, Human Genome, Cardiovascular, Aging, Prevention, Genetics, Cerebrovascular, 2.1 Biological and endogenous factors, Good Health and Well Being, Stroke Genetics Network (SiGN), the International Stroke Genetics Consortium (ISGC), METASTROKE, Alzheimer's Disease Genetics Consortium (ADGC), and the Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, Cognitive Sciences, Neurology & Neurosurgery, Clinical sciences
Abstract: ObjectiveTo explore genetic and lifestyle risk factors of MRI-defined brain infarcts (BI) in large population-based cohorts.MethodsWe performed meta-analyses of genome-wide association studies (GWAS) and examined associations of vascular risk factors and their genetic risk scores (GRS) with MRI-defined BI and a subset of BI, namely, small subcortical BI (SSBI), in 18 population-based cohorts (n = 20,949) from 5 ethnicities (3,726 with BI, 2,021 with SSBI). Top loci were followed up in 7 population-based cohorts (n = 6,862; 1,483 with BI, 630 with SBBI), and we tested associations with related phenotypes including ischemic stroke and pathologically defined BI.ResultsThe mean prevalence was 17.7% for BI and 10.5% for SSBI, steeply rising after age 65. Two loci showed genome-wide significant association with BI: FBN2, p = 1.77 × 10-8; and LINC00539/ZDHHC20, p = 5.82 × 10-9. Both have been associated with blood pressure (BP)-related phenotypes, but did not replicate in the smaller follow-up sample or show associations with related phenotypes. Age- and sex-adjusted associations with BI and SSBI were observed for BP traits (p value for BI, p [BI] = 9.38 × 10-25; p [SSBI] = 5.23 × 10-14 for hypertension), smoking (p [BI] = 4.4 × 10-10; p [SSBI] = 1.2 × 10-4), diabetes (p [BI] = 1.7 × 10-8; p [SSBI] = 2.8 × 10-3), previous cardiovascular disease (p [BI] = 1.0 × 10-18; p [SSBI] = 2.3 × 10-7), stroke (p [BI] = 3.9 × 10-69; p [SSBI] = 3.2 × 10-24), and MRI-defined white matter hyperintensity burden (p [BI] = 1.43 × 10-157; p [SSBI] = 3.16 × 10-106), but not with body mass index or cholesterol. GRS of BP traits were associated with BI and SSBI (p ≤ 0.0022), without indication of directional pleiotropy.ConclusionIn this multiethnic GWAS meta-analysis, including over 20,000 population-based participants, we identified genetic risk loci for BI requiring validation once additional large datasets become available. High BP, including genetically determined, was the most significant modifiable, causal risk factor for BI.
Published: 2019

2. Multi‐phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations

Author: Temprano‐Sagrera, Gerard, Sitlani, Colleen M., Bone, William P., Martin‐Bornez, Miguel, Voight, Benjamin F., Morrison, Alanna C., Damrauer, Scott M., de Vries, Paul S., Smith, Nicholas L., Sabater‐Lleal, Maria, Dehghan, Abbas, Heath, Adam S, Morrison, Alanna C, Reiner, Alex P, Johnson, Andrew, Richmond, Anne, Peters, Annette, van Hylckama Vlieg, Astrid, McKnight, Barbara, Psaty, Bruce M, Hayward, Caroline, Ward‐Caviness, Cavin, O’Donnell, Christopher, Chasman, Daniel, Strachan, David P, Tregouet, David A, Mook‐Kanamori, Dennis, Gill, Dipender, Thibord, Florian, Asselbergs, Folkert W, Leebeek, Frank W.G., Rosendaal, Frits R, Davies, Gail, Homuth, Georg, Temprano, Gerard, Campbell, Harry, Taylor, Herman A, Bressler, Jan, Huffman, Jennifer E, Rotter, Jerome I, Yao, Jie, Wilson, James F, Bis, Joshua C, Hahn, Julie M, Desch, Karl C, Wiggins, Kerri L, Raffield, Laura M, Bielak, Lawrence F, Yanek, Lisa R, Kleber, Marcus E, Mueller, Martina, Kavousi, Maryam, Mangino, Massimo, Liu, Melissa, Brown, Michael R, Conomos, Matthew P, Jhun, Min‐A, Chen, Ming‐Huei, de Maat, Moniek P.M., Pankratz, Nathan, Smith, Nicholas L, Peyser, Patricia A, Elliot, Paul, de Vries, Paul S, Wei, Peng, Wild, Philipp S, Morange, Pierre E, van der Harst, Pim, Yang, Qiong, Le, Ngoc‐Quynh, Marioni, Riccardo, Li, Ruifang, Damrauer, Scott M, Cox, Simon R, Trompet, Stella, Felix, Stephan B, Völker, Uwe, Tang, Weihong, Koenig, Wolfgang, Jukema, J. Wouter, Guo, Xiuqing, Lindstrom, Sara, Wang, Lu, Smith, Erin N, Gordon, William, de Andrade, Mariza, Brody, Jennifer A, Pattee, Jack W, Haessler, Jeffrey, Brumpton, Ben M, Chasman, Daniel I, Suchon, Pierre, Turman, Constance, Germain, Marine, MacDonald, James, Braekkan, Sigrid K, Armasu, Sebastian M, Jackson, Rabecca D, Nielsen, Jonas B, Giulianini, Franco, Puurunen, Marja K, Ibrahim, Manal, Heckbert, Susan R, Bammler, Theo K, Frazer, Kelly A, McCauley, Bryan M, Taylor, Kent, Pankow, James S, Reiner, Alexander P, Gabrielsen, Maiken E, Deleuze, Jean‐François, O’Donnell, Chris J, Kim, Jihye, Kraft, Peter, Hansen, John‐Bjarne, Heit, John A, Kooperberg, Charles, Hveem, Kristian, Ridker, Paul M, Morange, Pierre‐Emmanuel, Johnson, Andrew D, Kabrhel, Christopher, Trégouët, David‐Alexandre, Malik, Rainer, Chauhan, Ganesh, Traylor, Matthew, Sargurupremraj, Muralidharan, Okada, Yukinori, Mishra, Aniket, Rutten‐Jacobs, Loes, Giese, Anne‐Katrin, van der Laan, Sander W, Gretarsdottir, Solveig, Anderson, Christopher D, Chong, Michael, Adams, Hieab HH, Ago, Tetsuro, Almgren, Peter, Amouyel, Philippe, Ay, Hakan, Bartz, Traci M, Benavente, Oscar R, Bevan, Steve, Boncoraglio, Giorgio B, Brown, Robert D, Butterworth, Adam S, Carrera, Caty, Carty, Cara L, Chen, Wei‐Min, Cole, John W, Correa, Adolfo, Cotlarciuc, Ioana, Cruchaga, Carlos, Danesh, John, de Bakker, Paul IW, DeStefano, Anita L, den Hoed, Marcel, Duan, Qing, Engelter, Stefan T, Falcone, Guido J, Gottesman, Rebecca F, Grewal, Raji P, Gudnason, Vilmundur, Gustafsson, Stefan, Harris, Tamara B, Hassan, Ahamad, Havulinna, Aki S, Holliday, Elizabeth G, Howard, George, Hsu, Fang‐Chi, Hyacinth, Hyacinth I, Arfan Ikram, M, Ingelsson, Erik, Irvin, Marguerite R, Jian, Xueqiu, Jiménez‐Conde, Jordi, Johnson, Julie A, Jukema, J Wouter, Kanai, Masahiro, Keene, Keith L, Kissela, Brett M, Kleindorfer, Dawn O, Kubo, Michiaki, Lange, Leslie A, Langefeld, Carl D, Langenberg, Claudia, Launer, Lenore J, Lee, Jin‐Moo, Lemmens, Robin, Leys, Didier, Lewis, Cathryn M, Lin, Wei‐Yu, Lindgren, Arne G, Lorentzen, Erik, Magnusson, Patrik K, Maguire, Jane, Manichaikul, Ani, McArdle, Patrick F, Meschia, James F, Mitchell, Braxton D, Mosley, Thomas H, Nalls, Michael A, Ninomiya, Toshiharu, O’Donnell, Martin J, Pulit, Sara L, Rannikmäe, Kristiina, Rexrode, Kathryn M, Rice, Kenneth, Rich, Stephen S, Rost, Natalia S, Rothwell, Peter M, Rundek, Tatjana, Sacco, Ralph L, Sakaue, Saori, Sale, Michele M, Salomaa, Veikko, Sapkota, Bishwa R, Schmidt, Reinhold, Schmidt, Carsten O, Schminke, Ulf, Sharma, Pankaj, Slowik, Agnieszka, Sudlow, Cathie LM, Tanislav, Christian, Tatlisumak, Turgut, Taylor, Kent D, Thijs, Vincent NS, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tiedt, Steffen, Tzourio, Christophe, van Duijn, Cornelia M, Walters, Matthew, Wareham, Nicholas J, Wassertheil‐Smoller, Sylvia, Wilson, James G, Yusuf, Salim, Amin, Najaf, Aparicio, Hugo S, Arnett, Donna K, Attia, John, Beiser, Alexa S, Berr, Claudine, Buring, Julie E, Bustamante, Mariana, Caso, Valeria, Cheng, Yu‐Ching, Hoan Choi, Seung, Chowhan, Ayesha, Cullell, Natalia, Dartigues, Jean‐François, Delavaran, Hossein, Delgado, Pilar, Dörr, Marcus, Engström, Gunnar, Ford, Ian, Gurpreet, Wander S, Hamsten, Anders, Heitsch, Laura, Hozawa, Atsushi, Ibanez, Laura, Ilinca, Andreea, Ingelsson, Martin, Iwasaki, Motoki, Jackson, Rebecca D, Jood, Katarina, Jousilahti, Pekka, Kaffashian, Sara, Kalra, Lalit, Kamouchi, Masahiro, Kitazono, Takanari, Kjartansson, Olafur, Kloss, Manja, Koudstaal, Peter J, Krupinski, Jerzy, Labovitz, Daniel L, Laurie, Cathy C, Levi, Christopher R, Li, Linxin, Lind, Lars, Lindgren, Cecilia M, Lioutas, Vasileios, Mei Liu, Yong, Lopez, Oscar L, Makoto, Hirata, Martinez‐Majander, Nicolas, Matsuda, Koichi, Minegishi, Naoko, Montaner, Joan, Morris, Andrew P, Muiño, Elena, Müller‐Nurasyid, Martina, Norrving, Bo, Ogishima, Soichi, Parati, Eugenio A, Reddy Peddareddygari, Leema, Pedersen, Nancy L, Pera, Joanna, Perola, Markus, Pezzini, Alessandro, Pileggi, Silvana, Rabionet, Raquel, Riba‐Llena, Iolanda, Ribasés, Marta, Romero, Jose R, Roquer, Jaume, Rudd, Anthony G, Sarin, Antti‐Pekka, Sarju, Ralhan, Sarnowski, Chloe, Sasaki, Makoto, Satizabal, Claudia L, Satoh, Mamoru, Sattar, Naveed, Sawada, Norie, Sibolt, Gerli, Sigurdsson, Ásgeir, Smith, Albert, Sobue, Kenji, Soriano‐Tárraga, Carolina, Stanne, Tara, Colin Stine, O, Stott, David J, Strauch, Konstantin, Takai, Takako, Tanaka, Hideo, Tanno, Kozo, Teumer, Alexander, Tomppo, Liisa, Torres‐Aguila, Nuria P, Touze, Emmanuel, Tsugane, Shoichiro, Uitterlinden, Andre G, Valdimarsson, Einar M, van der Lee, Sven J, Völzke, Henry, Wakai, Kenji, Weir, David, Williams, Stephen R, Wolfe, Charles DA, Wong, Quenna, Xu, Huichun, Yamaji, Taiki, Sanghera, Dharambir K, Melander, Olle, Jern, Christina, Strbian, Daniel, Fernandez‐Cadenas, Israel, Longstreth, W T, Rolfs, Arndt, Hata, Jun, Woo, Daniel, Rosand, Jonathan, Pare, Guillaume, Hopewell, Jemma C, Saleheen, Danish, Stefansson, Kari, Worrall, Bradford B, Kittner, Steven J, Seshadri, Sudha, Fornage, Myriam, Markus, Hugh S, Howson, Joanna MM, Kamatani, Yoichiro, Debette, Stephanie, and Dichgans, Martin
Published: 2022
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3. Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

Author: Malik, Rainer, Chauhan, Ganesh, Traylor, Matthew, Sargurupremraj, Muralidharan, Okada, Yukinori, Mishra, Aniket, Rutten-Jacobs, Loes, Giese, Anne-Katrin, van der Laan, Sander W, Gretarsdottir, Solveig, Anderson, Christopher D, Chong, Michael, Adams, Hieab HH, Ago, Tetsuro, Almgren, Peter, Amouyel, Philippe, Ay, Hakan, Bartz, Traci M, Benavente, Oscar R, Bevan, Steve, Boncoraglio, Giorgio B, Brown, Robert D, Butterworth, Adam S, Carrera, Caty, Carty, Cara L, Chasman, Daniel I, Chen, Wei-Min, Cole, John W, Correa, Adolfo, Cotlarciuc, Ioana, Cruchaga, Carlos, Danesh, John, de Bakker, Paul IW, DeStefano, Anita L, den Hoed, Marcel, Duan, Qing, Engelter, Stefan T, Falcone, Guido J, Gottesman, Rebecca F, Grewal, Raji P, Gudnason, Vilmundur, Gustafsson, Stefan, Haessler, Jeffrey, Harris, Tamara B, Hassan, Ahamad, Havulinna, Aki S, Heckbert, Susan R, Holliday, Elizabeth G, Howard, George, Hsu, Fang-Chi, Hyacinth, Hyacinth I, Ikram, M Arfan, Ingelsson, Erik, Irvin, Marguerite R, Jian, Xueqiu, Jiménez-Conde, Jordi, Johnson, Julie A, Jukema, J Wouter, Kanai, Masahiro, Keene, Keith L, Kissela, Brett M, Kleindorfer, Dawn O, Kooperberg, Charles, Kubo, Michiaki, Lange, Leslie A, Langefeld, Carl D, Langenberg, Claudia, Launer, Lenore J, Lee, Jin-Moo, Lemmens, Robin, Leys, Didier, Lewis, Cathryn M, Lin, Wei-Yu, Lindgren, Arne G, Lorentzen, Erik, Magnusson, Patrik K, Maguire, Jane, Manichaikul, Ani, McArdle, Patrick F, Meschia, James F, Mitchell, Braxton D, Mosley, Thomas H, Nalls, Michael A, Ninomiya, Toshiharu, O’Donnell, Martin J, Psaty, Bruce M, Pulit, Sara L, Rannikmäe, Kristiina, Reiner, Alexander P, Rexrode, Kathryn M, Rice, Kenneth, Rich, Stephen S, Ridker, Paul M, Rost, Natalia S, Rothwell, Peter M, Rotter, Jerome I, Rundek, Tatjana, Sacco, Ralph L, Sakaue, Saori, and Sale, Michele M
Subjects: Biological Sciences, Genetics, Human Genome, Stroke, Clinical Research, Brain Disorders, Aetiology, 2.1 Biological and endogenous factors, Cardiovascular, Computational Biology, Databases, Genetic, Epigenesis, Genetic, Female, Gene Regulatory Networks, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, INDEL Mutation, Linkage Disequilibrium, Male, Models, Genetic, Polymorphism, Single Nucleotide, Risk Factors, AFGen Consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, International Genomics of Blood Pressure (iGEN-BP) Consortium, INVENT Consortium, STARNET, BioBank Japan Cooperative Hospital Group, COMPASS Consortium, EPIC-CVD Consortium, EPIC-InterAct Consortium, International Stroke Genetics Consortium, METASTROKE Consortium, Neurology Working Group of the CHARGE Consortium, NINDS Stroke Genetics Network, UK Young Lacunar DNA Study, MEGASTROKE Consortium, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract: Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown. We conducted a multiancestry genome-wide-association meta-analysis in 521,612 individuals (67,162 cases and 454,450 controls) and discovered 22 new stroke risk loci, bringing the total to 32. We further found shared genetic variation with related vascular traits, including blood pressure, cardiac traits, and venous thromboembolism, at individual loci (n = 18), and using genetic risk scores and linkage-disequilibrium-score regression. Several loci exhibited distinct association and pleiotropy patterns for etiological stroke subtypes. Eleven new susceptibility loci indicate mechanisms not previously implicated in stroke pathophysiology, with prioritization of risk variants and genes accomplished through bioinformatics analyses using extensive functional datasets. Stroke risk loci were significantly enriched in drug targets for antithrombotic therapy.
Published: 2018

4. Contribution of Common Genetic Variants to Risk of Early Onset Ischemic Stroke

Author: Jaworek, Thomas, Xu, Huichun, Gaynor, Brady J, Cole, John W., Rannikmae, Kristiina, Stanne, Tara M, Tomppo, Liisa, Abedi, Vida, Amouyel, Philippe, Armstrong, Nicole D, Attia, John, Bell, Steven, Benavente, Oscar R, Boncoraglio, Giorgio B, Butterworth, Adam, Carcel-Marquez, Jara, Chen, Zhengming, Chong, Michael, Cruchaga, Carlos, Cushman, Mary, Danesh, John, Debette, Stephanie, Duggan, David J, Durda, Jon Peter, Engstrom, Gunnar, Enzinger, Chris, Faul, Jessica D, Fecteau, Natalie S, Fernandez-Cadenas, Israel, Gieger, Christian, Giese, Anne-Katrin, Grewal, Raji P, Grittner, Ulrike, Havulinna, Aki S, Heitsch, Laura, Hochberg, Marc C, Holliday, Elizabeth, Hu, Jie, Ilinca, Andreea, Irvin, Marguerite R, Jackson, Rebecca D, Jacob, Mina A., Janssen, Raquel Rabionet, Jimenez-Conde, Jordi, Johnson, Julie A, Kamatani, Yoichiro, Kardia, Sharon L, Koido, Masaru, Kubo, Michiaki, Lange, Leslie, Lee, Jin-Moo, Lemmens, Robin, Levi, Christopher R, Li, Jiang, Li, Liming, Lin, Kuang, Lopez, Haley, Luke, Sothear, Maguire, Jane, McArdle, Patrick F, McDonough, Caitrin W., Meschia, James F, Metso, Tiina, Muller-Nurasyid, Martina, OʼConnor, Timothy D, OʼDonnell, Martin, Peddareddygari, Leema R, Pera, Joanna, Perry, James A, Peters, Annette, Putaala, Jukka, Ray, Debashree, Rexrode, Kathryn, Ribases, Marta, Rosand, Jonathan, Rothwell, Peter M, Rundek, Tatjana, Ryan, Kathleen A, Sacco, Ralph L., Salomaa, Veikko, Sanchez-Mora, Cristina, Schmidt, Reinhold, Sharma, Pankaj, Slowik, Agnieszka, Smith, Jennifer A, Smith, Nicholas L, Wassertheil-Smoller, Sylvia, Soederholm, Martin, Stine, O. C, Strbian, Daniel, Sudlow, Cathie L, Tatlisumak, Turgut, Terao, Chikashi, Thijs, Vincent, Torres-Aguila, Nuria P, Tregouet, David-Alexandre, Tuladhar, Anil M., Veldink, Jan H, Walters, Robin G, Weir, David R, Woo, Daniel, Worrall, Bradford B, Hong, Charles C, Ross, Owen, Zand, Ramin, Leeuw, Frank-Erik de, Lindgren, Arne G, Pare, Guillaume, Anderson, Christopher D., Markus, Hugh S, Jern, Christina, Malik, Rainer, Dichgans, Martin, Mitchell, Braxton D, and Kittner, Steven J
Published: 2022
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5. Antiplatelet drugs for secondary prevention in patients with ischemic stroke or transient ischemic attack: a systematic review and network meta-analysis

Author: Del Giovane, Cinzia, Boncoraglio, Giorgio B., Bertù, Lorenza, Banzi, Rita, and Tramacere, Irene
Published: 2021
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6. Serum magnesium and calcium levels in relation to ischemic stroke: Mendelian randomization study

Author: Larsson, Susanna C., Traylor, Matthew, Burgess, Stephen, Boncoraglio, Giorgio B., Jern, Christina, Michaëlsson, Karl, Markus, Hugh S., Malik, Rainer, Chauhan, Ganesh, Traylor, Matthew, Sargurupremraj, Muralidharan, Okada, Yukinori, Mishra, Aniket, Rutten-Jacobs, Loes, Giese, Anne-Katrin, van der Laan, Sander W, Gretarsdottir, Solveig, Anderson, Christopher D, Chong, Michael, Adams, Hieab HH, Ago, Tetsuro, Almgren, Peter, Amouyel, Philippe, Ay, Hakan, Bartz, raci M, Benavente, Oscar R, Bevan, Steve, Boncoraglio, Giorgio B, Brown, Robert D, Jr., Butterworth, Adam S, Carrera, Caty, Carty, Cara L, Chasman, Daniel I, Chen, Wei-Min, Cole, John W, Correa, Adolfo, Cotlarciuc, Ioana, Cruchaga, Carlos, Danesh, John, de Bakker, Paul IW, DeStefano, Anita L, Hoed, Marcel den, Duan, Qing, Engelter, Stefan T, Falcone, Guido J, Gottesman, Rebecca F, Grewal, Raji P, Gudnason, Vilmundur, Gustafsson, Stefan, Haessler, Jeffrey, Harris, Tamara B, Hassan, Ahamad, Havulinna, Aki S, Heckbert, Susan R, Holliday, Elizabeth G, Howard, George, Hsu, Fang-Chi, Hyacinth, Hyacinth I, Ikram, M Arfan, Ingelsson, Erik, Irvin, Marguerite R, Jian, Xueqiu, Jiménez-Conde, Jordi, Johnson, Julie A, Jukema, J Wouter, Kanai, Masahiro, Keene, Keith L, Kissela, Brett M, Kleindorfer, Dawn O, Kooperberg, Charles, Kubo, Michiaki, Lange, Leslie A, Langefeld, Carl D, Langenberg, Claudia, Launer, Lenore J, Lee, Jin-Moo, Lemmens, Robin, Leys, Didier, Lewis, Cathryn M, Lin, Wei-Yu, Lindgren, Arne G, Lorentzen, Erik, Magnusson, Patrik K, Maguire, Jane, Manichaikul, Ani, McArdle, Patrick F, Meschia, James F, Mitchell, Braxton D, Mosley, Thomas H, Nalls, Michael A, Ninomiya, Toshiharu, OʼDonnell, Martin J, Psaty, Bruce M, Pulit, Sara L, Rannikmäe, Kristiina, Reiner, Alexander P, Rexrode, Kathryn M, Rice, Kenneth, Rich, Stephen S, Ridker, Paul M, Rost, Natalia S, Rothwell, Peter M, Rotter, Jerome I, Rundek, Tatjana, Sacco, Ralph L, Sakaue, Saori, Sale, Michele M, Salomaa, Veikko, Sapkota, Bishwa R, Schmidt, Reinhold, Schmidt, Carsten O, Schminke, Ulf, Sharma, Pankaj, Slowik, Agnieszka, Sudlow, Cathie LM, Tanislav, Christian, Tatlisumak, Turgut, Taylor, Kent D, Thijs, Vincent NS, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tiedt, Steffen, Trompet, Stella, Tzourio, Christophe, van Duijn, Cornelia M, Walters, Matthew, Wareham, Nicholas J, Wassertheil-Smoller, Sylvia, Wilson, James G, Wiggins, Kerri L, Yang, Qiong, Yusuf, Salim, Amin, Najaf, Aparicio, Hugo S, Arnett, Donna K, Attia, John, Beiser, Alexa S, Berr, Claudine, Buring, Julie E, Bustamante, Mariana, Caso, Valeria, Cheng, Yu-Ching, Choi, Seung Hoan, Chowhan, Ayesha, Cullell, Natalia, Dartigues, Jean-François, Delavaran, Hossein, Delgado, Pilar, Dörr, Marcus, Engström, Gunnar, Ford, Ian, Gurpreet, Wander S, Hamsten, Anders, Heitsch, Laura, Hozawa, Atsushi, Ibanez, Laura, Ilinca, Andreea, Ingelsson, Martin, Iwasaki, Motoki, Jackson, Rebecca D, Jood, Katarina, Jousilahti, Pekka, Kaffashian, Sara, Kalra, Lalit, Kamouchi, Masahiro, Kitazono, Takanari, Kjartansson, Olafur, Kloss, Manja, Koudstaal, Peter J, Krupinski, Jerzy, Labovitz, Daniel L, Laurie, Cathy C, Levi, Christopher R, Li, Linxin, Lind, Lars, Lindgren, Cecilia M, Lioutas, Vasileios, Liu, Yong Mei, Lopez, Oscar L, Makoto, Hirata, Martinez-Majander, Nicolas, Matsuda, Koichi, Minegishi, Naoko, Montaner, Joan, Morris, Andrew P, Muiño, Elena, Müller-Nurasyid, Martina, Norrving, Bo, Ogishima, Soichi, Parati, Eugenio A, Peddareddygari, Leema Reddy, Pedersen, Nancy L, Pera, Joanna, Perola, Markus, Pezzini, Alessandro, Pileggi, Silvana, Rabionet, Raquel, Riba-Llena, Iolanda, Ribasés, Marta, Romero, Jose R, Roquer, Jaume, Rudd, Anthony G, Sarin, Antti-Pekka, Sarju, Ralhan, Sarnowski, Chloe, Sasaki, Makoto, Satizabal, Claudia L, Satoh, Mamoru, Sattar, Naveed, Sawada, Norie, Sibolt, Gerli, Sigurdsson, Ásgeir, Smith, Albert, Sobue, Kenji, Soriano-Tárraga, Carolina, Stanne, Tara, Stine, O Colin, Stott, David J, Strauch, Konstantin, Takai, Takako, Tanaka, Hideo, Tanno, Kozo, Teumer, Alexander, Tomppo, Liisa, Torres-Aguila, Nuria P, Touze, Emmanuel, Tsugane, Shoichiro, Uitterlinden, Andre G, Valdimarsson, Einar M, van der Lee, Sven J, Völzke, Henry, Wakai, Kenji, Weir, David, Williams, Stephen R, Wolfe, Charles DA, Wong, Quenna, Xu, Huichun, Yamaji, Taiki, Sanghera, Dharambir K, Melander, Olle, Jern, Christina, Strbian, Daniel, Fernandez-Cadenas, Israel, Longstreth, W T, Jr, Rolfs, Arndt, Hata, Jun, Woo, Daniel, Rosand, Jonathan, Pare, Guillaume, Hopewell, Jemma C, Saleheen, Danish, Stefansson, Kari, Worrall, Bradford B, Kittner, Steven J, Seshadri, Sudha, Fornage, Myriam, Markus, Hugh S, Howson, Joanna MM, Kamatani, Yoichiro, Debette, Stephanie, and Dichgans, Martin
Published: 2019
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7. Comparison of statins for secondary prevention in patients with ischemic stroke or transient ischemic attack: a systematic review and network meta-analysis

Author: Tramacere, Irene, Boncoraglio, Giorgio B., Banzi, Rita, Del Giovane, Cinzia, Kwag, Koren H., Squizzato, Alessandro, and Moja, Lorenzo
Published: 2019
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8. Anti-Cyclic Citrullinated Peptide Antibody Index in the Cerebrospinal Fluid for the Diagnosis and Monitoring of Rheumatoid Meningitis

Author: Caputi, Luigi, primary, Boncoraglio, Giorgio B., additional, Bernardi, Gaetano, additional, Ciusani, Emilio, additional, Dantes, Marcello, additional, de Liso, Federica, additional, Erbetta, Alessandra, additional, Marucci, Gianluca, additional, Matinato, Caterina, additional, and Corsini, Elena, additional
Published: 2022
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9. Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

Author: Malik, Rainer, Chauhan, Ganesh, Traylor, Matthew, Sargurupremraj, Muralidharan, Okada, Yukinori, Mishra, Aniket, Rutten-Jacobs, Loes, Giese, Anne-Katrin, van der Laan, Sander W., Gretarsdottir, Solveig, Anderson, Christopher D., Chong, Michael, Adams, Hieab H. H., Ago, Tetsuro, Almgren, Peter, Amouyel, Philippe, Ay, Hakan, Bartz, Traci M., Benavente, Oscar R., Bevan, Steve, Boncoraglio, Giorgio B., Brown, Jr, Robert D., Butterworth, Adam S., Carrera, Caty, Carty, Cara L., Chasman, Daniel I., Chen, Wei-Min, Cole, John W., Correa, Adolfo, Cotlarciuc, Ioana, Cruchaga, Carlos, Danesh, John, de Bakker, Paul I. W., DeStefano, Anita L., den Hoed, Marcel, Duan, Qing, Engelter, Stefan T., Falcone, Guido J., Gottesman, Rebecca F., Grewal, Raji P., Gudnason, Vilmundur, Gustafsson, Stefan, Haessler, Jeffrey, Harris, Tamara B., Hassan, Ahamad, Havulinna, Aki S., Heckbert, Susan R., Holliday, Elizabeth G., Howard, George, Hsu, Fang-Chi, Hyacinth, Hyacinth I., Ikram, M. Arfan, Ingelsson, Erik, Irvin, Marguerite R., Jian, Xueqiu, Jiménez-Conde, Jordi, Johnson, Julie A., Jukema, J. Wouter, Kanai, Masahiro, Keene, Keith L., Kissela, Brett M., Kleindorfer, Dawn O., Kooperberg, Charles, Kubo, Michiaki, Lange, Leslie A., Langefeld, Carl D., Langenberg, Claudia, Launer, Lenore J., Lee, Jin-Moo, Lemmens, Robin, Leys, Didier, Lewis, Cathryn M., Lin, Wei-Yu, Lindgren, Arne G., Lorentzen, Erik, Magnusson, Patrik K., Maguire, Jane, Manichaikul, Ani, McArdle, Patrick F., Meschia, James F., Mitchell, Braxton D., Mosley, Thomas H., Nalls, Michael A., Ninomiya, Toshiharu, O’Donnell, Martin J., Psaty, Bruce M., Pulit, Sara L., Rannikmäe, Kristiina, Reiner, Alexander P., Rexrode, Kathryn M., Rice, Kenneth, Rich, Stephen S., Ridker, Paul M., Rost, Natalia S., Rothwell, Peter M., Rotter, Jerome I., Rundek, Tatjana, Sacco, Ralph L., Sakaue, Saori, Sale, Michele M., Salomaa, Veikko, Sapkota, Bishwa R., Schmidt, Reinhold, Schmidt, Carsten O., Schminke, Ulf, Sharma, Pankaj, Slowik, Agnieszka, Sudlow, Cathie L. M., Tanislav, Christian, Tatlisumak, Turgut, Taylor, Kent D., Thijs, Vincent N. S., Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tiedt, Steffen, Trompet, Stella, Tzourio, Christophe, van Duijn, Cornelia M., Walters, Matthew, Wareham, Nicholas J., Wassertheil-Smoller, Sylvia, Wilson, James G., Wiggins, Kerri L., Yang, Qiong, Yusuf, Salim, AFGen Consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, International Genomics of Blood Pressure (iGEN-BP) Consortium, INVENT Consortium, STARNET, Bis, Joshua C., Pastinen, Tomi, Ruusalepp, Arno, Schadt, Eric E., Koplev, Simon, Björkegren, Johan L. M., Codoni, Veronica, Civelek, Mete, Smith, Nicholas L., Trégouët, David A., Christophersen, Ingrid E., Roselli, Carolina, Lubitz, Steven A., Ellinor, Patrick T., Tai, E. Shyong, Kooner, Jaspal S., Kato, Norihiro, He, Jiang, van der Harst, Pim, Elliott, Paul, Chambers, John C., Takeuchi, Fumihiko, Johnson, Andrew D., BioBank Japan Cooperative Hospital Group, COMPASS Consortium, EPIC-CVD Consortium, EPIC-InterAct Consortium, International Stroke Genetics Consortium (ISGC), METASTROKE Consortium, Neurology Working Group of the CHARGE Consortium, NINDS Stroke Genetics Network (SiGN), UK Young Lacunar DNA Study, MEGASTROKE Consortium, Sanghera, Dharambir K., Melander, Olle, Jern, Christina, Strbian, Daniel, Fernandez-Cadenas, Israel, Longstreth, Jr, W. T., Rolfs, Arndt, Hata, Jun, Woo, Daniel, Rosand, Jonathan, Pare, Guillaume, Hopewell, Jemma C., Saleheen, Danish, Stefansson, Kari, Worrall, Bradford B., Kittner, Steven J., Seshadri, Sudha, Fornage, Myriam, Markus, Hugh S., Howson, Joanna M. M., Kamatani, Yoichiro, Debette, Stephanie, and Dichgans, Martin
Published: 2019
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10. Stroke genetics informs drug discovery and risk prediction across ancestries

Author: Mishra, Aniket, Malik, Rainer, Hachiya, Tsuyoshi, Jurgenson, Tuuli, Namba, Shinichi, Posner, Daniel C, Kamanu, Frederick K, Koido, Masaru, Le Grand, Quentin, Shi, Mingyang, He, Yunye, Georgakis, Marios K, Caro, Ilana, Krebs, Kristi, Liaw, Yi-Ching, Vaura, Felix C, Lin, Kuang, Winsvold, Bendik Slagsvold, Srinivasasainagendra, Vinodh, Parodi, Livia, Bae, Hee-Joon, Chauhan, Ganesh, Chong, Michael R, Tomppo, Liisa, Akinyemi, Rufus, Roshchupkin, Gennady V, Habib, Naomi, Jee, Yon Ho, Thomassen, Jesper Qvist, Abedi, Vida, Carcel-Marquez, Jara, Nygaard, Marianne, Leonard, Hampton L, Yang, Chaojie, Yonova-Doing, Ekaterina, Knol, Maria J, Lewis, Adam J, Judy, Renae L, Ago, Tetsuro, Amouyel, Philippe, Armstrong, Nicole D, Bakker, Mark K, Bartz, Traci M, Bennett, David A, Bis, Joshua C, Bordes, Constance, Borte, Sigrid, Cain, Anael, Ridker, Paul M, Cho, Kelly, Chen, Zhengming, Cruchaga, Carlos, Cole, John W, de Jager, Phil L, de Cid, Rafael, Endres, Matthias, Ferreira, Leslie E, Geerlings, Mirjam I, Gasca, Natalie C, Gudnason, Vilmundur, Hata, Jun, He, Jing, Heath, Alicia K, Ho, Yuk-Lam, Havulinna, Aki S, Hopewell, Jemma C, Hyacinth, Hyacinth I, Inouye, Michael, Jacob, Mina A, Jeon, Christina E, Jern, Christina, Kamouchi, Masahiro, Keene, Keith L, Kitazono, Takanari, Kittner, Steven J, Konuma, Takahiro, Kumar, Amit, Lacaze, Paul, Launer, Lenore J, Lee, Keon-Joo, Lepik, Kaido, Li, Jiang, Li, Liming, Manichaikul, Ani, Markus, Hugh S, Marston, Nicholas A, Meitinger, Thomas, Mitchell, Braxton D, Montellano, Felipe A, Morisaki, Takayuki, Mosley, Thomas H, Nalls, Mike A, Nordestgaard, Borge G, O'Donnell, Martin J, Okada, Yukinori, Onland-Moret, N Charlotte, Ovbiagele, Bruce, Peters, Annette, Psaty, Bruce M, Rich, Stephen S, Rosand, Jonathan, Sabatine, Marc S, Sacco, Ralph L, Saleheen, Danish, Sandset, Else Charlotte, Salomaa, Veikko, Sargurupremraj, Muralidharan, Sasaki, Makoto, Satizabal, Claudia L, Schmidt, Carsten O, Shimizu, Atsushi, Smith, Nicholas L, Sloane, Kelly L, Sutoh, Yoichi, Sun, Yan V, Tanno, Kozo, Tiedt, Steffen, Tatlisumak, Turgut, Torres-Aguila, Nuria P, Tiwari, Hemant K, Tregouet, David-Alexandre, Trompet, Stella, Tuladhar, Anil Man, Tybjaerg-Hansen, Anne, van Vugt, Marion, Vibo, Riina, Verma, Shefali S, Wiggins, Kerri L, Wennberg, Patrik, Woo, Daniel, Wilson, Peter WF, Xu, Huichun, Yang, Qiong, Yoon, Kyungheon, Lee, Jin-Moo, Cheng, Yu-Ching, Meschia, James F, Chen, Wei Min, Sale, Michele M, Zonderman, Alan B, Evans, Michele K, Wilson, James G, Correa, Adolfo, Traylor, Matthew, Lewis, Cathryn M, Carty, Cara L, Reiner, Alexander, Haessler, Jeffrey, Langefeld, Carl D, Gottesman, Rebecca F, Yaffe, Kristine, Liu, Yong Mei, Kooperberg, Charles, Lange, Leslie A, Furie, Karen L, Arnett, Donna K, Benavente, Oscar R, Grewal, Raji P, Peddareddygari, Leema Reddy, Hveem, Kristian, Lindstrom, Sara, Wang, Lu, Smith, Erin N, Gordon, William, van Hylckama Vlieg, Astrid, de Andrade, Mariza, Brody, Jennifer A, Pattee, Jack W, Brumpton, Ben M, Suchon, Pierre, Chen, Ming-Huei, Frazer, Kelly A, Turman, Constance, Germain, Marine, MacDonald, James, Braekkan, Sigrid K, Armasu, Sebastian M, Pankratz, Nathan, Jackson, Rebecca D, Nielsen, Jonas B, Giulianini, Franco, Puurunen, Marja K, Ibrahim, Manal, Heckbert, Susan R, Bammler, Theo K, McCauley, Bryan M, Taylor, Kent D, Pankow, James S, Reiner, Alexander P, Gabrielsen, Maiken E, Deleuze, Jean-Francois, O'Donnell, Chris J, Kim, Jihye, McKnight, Barbara, Kraft, Peter, Hansen, John-Bjarne, Rosendaal, Frits R, Heit, John A, Tang, Weihong, Morange, Pierre-Emmanuel, Johnson, Andrew D, Kabrhel, Christopher, van Dijk, Ewoud J, Koudstaal, Peter J, Luijckx, Gert-Jan, Nederkoorn, Paul J, van Oostenbrugge, Robert J, Visser, Marieke C, Wermer, Marieke JH, Kappelle, L Jaap, Esko, Tonu, Metspalu, Andres, Magi, Reedik, Nelis, Mari, Irvin, Marguerite R, de Leeuw, Frank-Erik, Levi, Christopher R, Maguire, Jane, Jimenez-Conde, Jordi, Sharma, Pankaj, Sudlow, Cathie LM, Rannikmae, Kristiina, Schmidt, Reinhold, Slowik, Agnieszka, Pera, Joanna, Thijs, Vincent NS, Lindgren, Arne G, Ilinca, Andreea, Melander, Olle, Engstrom, Gunnar, Rexrode, Kathryn M, Rothwell, Peter M, Stanne, Tara M, Johnson, Julie A, Danesh, John, Butterworth, Adam S, Heitsch, Laura, Boncoraglio, Giorgio B, Kubo, Michiaki, Pezzini, Alessandro, Rolfs, Arndt, Giese, Anne-Katrin, Weir, David, Ross, Owen A, Lemmons, Robin, Soderholm, Martin, Cushman, Mary, Jood, Katarina, McDonough, Caitrin W, Bell, Steven, Linkohr, Birgit, Lee, Tsong-Hai, Putaala, Jukka, Anderson, Christopher D, Lopez, Oscar L, Jian, Xueqiu, Schminke, Ulf, Cullell, Natalia, Delgado, Pilar, Ibanez, Laura, Krupinski, Jerzy, Lioutas, Vasileios, Matsuda, Koichi, Montaner, Joan, Muino, Elena, Roquer, Jaume, Sarnowski, Chloe, Sattar, Naveed, Sibolt, Gerli, Teumer, Alexander, Rutten-Jacobs, Loes, Kanai, Masahiro, Gretarsdottir, Solveig, Rost, Natalia S, Yusuf, Salim, Almgren, Peter, Ay, Hakan, Bevan, Steve, Brown, Robert D, Carrera, Caty, Buring, Julie E, Chen, Wei-Min, Cotlarciuc, Ioana, de Bakker, Paul IW, DeStefano, Anita L, den Hoed, Marcel, Duan, Qing, Engelter, Stefan T, Falcone, Guido J, Gustafsson, Stefan, Hassan, Ahamad, Holliday, Elizabeth G, Howard, George, Hsu, Fang-Chi, Ingelsson, Erik, Harris, Tamara B, Kissela, Brett M, Kleindorfer, Dawn O, Langenberg, Claudia, Lemmens, Robin, Leys, Didier, Lin, Wei-Yu, Lorentzen, Erik, Magnusson, Patrik K, McArdle, Patrick F, Pulit, Sara L, Rice, Kenneth, Sakaue, Saori, Sapkota, Bishwa R, Tanislav, Christian, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tzourio, Christophe, van Duijn, Cornelia M, Walters, Matthew, Wareham, Nicholas J, Amin, Najaf, Aparicio, Hugo J, Attia, John, Beiser, Alexa S, Berr, Claudine, Bustamante, Mariana, Caso, Valeria, Choi, Seung Hoan, Chowhan, Ayesha, Dartigues, Jean-Francois, Delavaran, Hossein, Dorr, Marcus, Ford, Ian, Gurpreet, Wander S, Hamsten, Anders, Hozawa, Atsushi, Ingelsson, Martin, Iwasaki, Motoki, Kaffashian, Sara, Kalra, Lalit, Kjartansson, Olafur, Kloss, Manja, Labovitz, Daniel L, Laurie, Cathy C, Li, Linxin, Lind, Lars, Lindgren, Cecilia M, Makoto, Hirata, Minegishi, Naoko, Morris, Andrew P, Muller-Nurasyid, Martina, Norrving, Bo, Ogishima, Soichi, Parati, Eugenio A, Pedersen, Nancy L, Perola, Markus, Jousilahti, Pekka, Pileggi, Silvana, Rabionet, Raquel, Riba-Llena, Iolanda, Ribases, Marta, Romero, Jose R, Rudd, Anthony G, Sarin, Antti-Pekka, Sarju, Ralhan, Satoh, Mamoru, Sawada, Norie, Sigurdsson, Asgeir, Smith, Albert, Stine, O Colin, Stott, David J, Strauch, Konstantin, Takai, Takako, Tanaka, Hideo, Touze, Emmanuel, Tsugane, Shoichiro, Uitterlinden, Andre G, Valdimarsson, Einar M, van der Lee, Sven J, Wakai, Kenji, Williams, Stephen R, Wolfe, Charles DA, Wong, Quenna, Yamaji, Taiki, Sanghera, Dharambir K, Stefansson, Kari, Martinez-Majander, Nicolas, Sobue, Kenji, Soriano-Tarraga, Carolina, Volzke, Henry, Akpa, Onoja, Sarfo, Fred S, Akpalu, Albert, Obiako, Reginald, Wahab, Kolawole, Osaigbovo, Godwin, Owolabi, Lukman, Komolafe, Morenikeji, Jenkins, Carolyn, Arulogun, Oyedunni, Ogbole, Godwin, Adeoye, Abiodun M, Akinyemi, Joshua, Agunloye, Atinuke, Fakunle, Adekunle G, Uvere, Ezinne, Olalere, Abimbola, Adebajo, Olayinka J, Chen, Junshi, Clarke, Robert, Collins, Rory, Guo, Yu, Wang, Chen, Lv, Jun, Peto, Richard, Chen, Yiping, Fairhurst-Hunter, Zammy, Hill, Michael, Pozarickij, Alfred, Schmidt, Dan, Stevens, Becky, Turnbull, Iain, Yu, Canqing, Nagai, Akiko, Murakami, Yoishinori, Shiroma, Eric J, Sigurdsson, Sigurdur, Ghanbari, Mohsen, Boerwinkle, Eric, Fongang, Bernard, Wang, Ruiqi, Ikram, Mohammad K, Volker, Uwe, de Laat, Karlijn F, van Norden, Anouk GW, de Kort, Paul L, Vermeer, Sarah E, Brouwers, Paul JAM, Gons, Rob AR, den Heijer, Tom, van Dijk, Gert W, van Rooij, Frank GW, Aamodt, Anne H, Skogholt, Anne H, Willer, Cristen J, Heuch, Ingrid, Hagen, Knut, Fritsche, Lars G, Pedersen, Linda M, Ellekjaer, Hanne, Zhou, Wei, Martinsen, Amy E, Kristoffersen, Espen S, Thomas, Laurent F, Kleinschnitz, Christoph, Frantz, Stefan, Ungethum, Kathrin, Gallego-Fabrega, Cristina, Lledos, Miquel, Llucia-Carol, Laia, Sobrino, Tomas, Campos, Francisco, Castillo, Jose, Freijo, Marimar, Arenillas, Juan Francisco, Obach, Victor, Alvarez-Sabin, Jose, Molina, Carlos A, Ribo, Marc, Munoz-Narbona, Lucia, Lopez-Cancio, Elena, Millan, Monica, Diaz-Navarro, Rosa, Vives-Bauza, Cristofol, Serrano-Heras, Gemma, Segura, Tomas, Dhar, Rajat, Delgado-Mederos, Raquel, Prats-Sanchez, Luis, Camps-Renom, Pol, Blay, Natalia, Sumoy, Lauro, Marti-Fabregas, Joan, Schnohr, Peter, Jensen, Gorm B, Benn, Marianne, Afzal, Shoaib, Kamstrup, Pia R, van Setten, Jessica, van der Laan, Sander W, Vonk, Jet MJ, Kim, Bong-Jo, Curtze, Sami, Tiainen, Marjaana, Kinnunen, Janne, Menon, Vilas, Sung, Yun Ju, Yang, Chengran, Saillour-Glenisson, Florence, Gravel, Simon, Millwood, Iona Y, Gieger, Christian, Ninomiya, Toshiharu, Grabe, Hans J, Jukema, J Wouter, Rissanen, Ina L, Strbian, Daniel, Kim, Young Jin, Chen, Pei-Hsin, Mayerhofer, Ernst, Howson, Joanna MM, Adams, Hieab, Wassertheil-Smoller, Sylvia, Christensen, Kaare, Ikram, Mohammad A, Rundek, Tatjana, Worrall, Bradford B, Lathrop, G Mark, Riaz, Moeen, Simonsick, Eleanor M, Korv, Janika, Franca, Paulo HC, Zand, Ramin, Prasad, Kameshwar, Frikke-Schmidt, Ruth, Liman, Thomas, Haeusler, Karl Georg, Ruigrok, Ynte M, Heuschmann, Peter Ulrich, Longstreth, WT, Jung, Keum Ji, Bastarache, Lisa, Pare, Guillaume, Damrauer, Scott M, Chasman, Daniel I, Rotter, Jerome I, Zwart, John-Anker, Niiranen, Teemu J, Fornage, Myriam, Liaw, Yung-Po, Seshadri, Sudha, Fernandez-Cadenas, Israel, Walters, Robin G, Ruff, Christian T, Owolabi, Mayowa O, Huffman, Jennifer E, Milani, Lili, Kamatani, Yoichiro, Dichgans, Martin, Debette, Stephanie, Mishra, Aniket, Malik, Rainer, Hachiya, Tsuyoshi, Jurgenson, Tuuli, Namba, Shinichi, Posner, Daniel C, Kamanu, Frederick K, Koido, Masaru, Le Grand, Quentin, Shi, Mingyang, He, Yunye, Georgakis, Marios K, Caro, Ilana, Krebs, Kristi, Liaw, Yi-Ching, Vaura, Felix C, Lin, Kuang, Winsvold, Bendik Slagsvold, Srinivasasainagendra, Vinodh, Parodi, Livia, Bae, Hee-Joon, Chauhan, Ganesh, Chong, Michael R, Tomppo, Liisa, Akinyemi, Rufus, Roshchupkin, Gennady V, Habib, Naomi, Jee, Yon Ho, Thomassen, Jesper Qvist, Abedi, Vida, Carcel-Marquez, Jara, Nygaard, Marianne, Leonard, Hampton L, Yang, Chaojie, Yonova-Doing, Ekaterina, Knol, Maria J, Lewis, Adam J, Judy, Renae L, Ago, Tetsuro, Amouyel, Philippe, Armstrong, Nicole D, Bakker, Mark K, Bartz, Traci M, Bennett, David A, Bis, Joshua C, Bordes, Constance, Borte, Sigrid, Cain, Anael, Ridker, Paul M, Cho, Kelly, Chen, Zhengming, Cruchaga, Carlos, Cole, John W, de Jager, Phil L, de Cid, Rafael, Endres, Matthias, Ferreira, Leslie E, Geerlings, Mirjam I, Gasca, Natalie C, Gudnason, Vilmundur, Hata, Jun, He, Jing, Heath, Alicia K, Ho, Yuk-Lam, Havulinna, Aki S, Hopewell, Jemma C, Hyacinth, Hyacinth I, Inouye, Michael, Jacob, Mina A, Jeon, Christina E, Jern, Christina, Kamouchi, Masahiro, Keene, Keith L, Kitazono, Takanari, Kittner, Steven J, Konuma, Takahiro, Kumar, Amit, Lacaze, Paul, Launer, Lenore J, Lee, Keon-Joo, Lepik, Kaido, Li, Jiang, Li, Liming, Manichaikul, Ani, Markus, Hugh S, Marston, Nicholas A, Meitinger, Thomas, Mitchell, Braxton D, Montellano, Felipe A, Morisaki, Takayuki, Mosley, Thomas H, Nalls, Mike A, Nordestgaard, Borge G, O'Donnell, Martin J, Okada, Yukinori, Onland-Moret, N Charlotte, Ovbiagele, Bruce, Peters, Annette, Psaty, Bruce M, Rich, Stephen S, Rosand, Jonathan, Sabatine, Marc S, Sacco, Ralph L, Saleheen, Danish, Sandset, Else Charlotte, Salomaa, Veikko, Sargurupremraj, Muralidharan, Sasaki, Makoto, Satizabal, Claudia L, Schmidt, Carsten O, Shimizu, Atsushi, Smith, Nicholas L, Sloane, Kelly L, Sutoh, Yoichi, Sun, Yan V, Tanno, Kozo, Tiedt, Steffen, Tatlisumak, Turgut, Torres-Aguila, Nuria P, Tiwari, Hemant K, Tregouet, David-Alexandre, Trompet, Stella, Tuladhar, Anil Man, Tybjaerg-Hansen, Anne, van Vugt, Marion, Vibo, Riina, Verma, Shefali S, Wiggins, Kerri L, Wennberg, Patrik, Woo, Daniel, Wilson, Peter WF, Xu, Huichun, Yang, Qiong, Yoon, Kyungheon, Lee, Jin-Moo, Cheng, Yu-Ching, Meschia, James F, Chen, Wei Min, Sale, Michele M, Zonderman, Alan B, Evans, Michele K, Wilson, James G, Correa, Adolfo, Traylor, Matthew, Lewis, Cathryn M, Carty, Cara L, Reiner, Alexander, Haessler, Jeffrey, Langefeld, Carl D, Gottesman, Rebecca F, Yaffe, Kristine, Liu, Yong Mei, Kooperberg, Charles, Lange, Leslie A, Furie, Karen L, Arnett, Donna K, Benavente, Oscar R, Grewal, Raji P, Peddareddygari, Leema Reddy, Hveem, Kristian, Lindstrom, Sara, Wang, Lu, Smith, Erin N, Gordon, William, van Hylckama Vlieg, Astrid, de Andrade, Mariza, Brody, Jennifer A, Pattee, Jack W, Brumpton, Ben M, Suchon, Pierre, Chen, Ming-Huei, Frazer, Kelly A, Turman, Constance, Germain, Marine, MacDonald, James, Braekkan, Sigrid K, Armasu, Sebastian M, Pankratz, Nathan, Jackson, Rebecca D, Nielsen, Jonas B, Giulianini, Franco, Puurunen, Marja K, Ibrahim, Manal, Heckbert, Susan R, Bammler, Theo K, McCauley, Bryan M, Taylor, Kent D, Pankow, James S, Reiner, Alexander P, Gabrielsen, Maiken E, Deleuze, Jean-Francois, O'Donnell, Chris J, Kim, Jihye, McKnight, Barbara, Kraft, Peter, Hansen, John-Bjarne, Rosendaal, Frits R, Heit, John A, Tang, Weihong, Morange, Pierre-Emmanuel, Johnson, Andrew D, Kabrhel, Christopher, van Dijk, Ewoud J, Koudstaal, Peter J, Luijckx, Gert-Jan, Nederkoorn, Paul J, van Oostenbrugge, Robert J, Visser, Marieke C, Wermer, Marieke JH, Kappelle, L Jaap, Esko, Tonu, Metspalu, Andres, Magi, Reedik, Nelis, Mari, Irvin, Marguerite R, de Leeuw, Frank-Erik, Levi, Christopher R, Maguire, Jane, Jimenez-Conde, Jordi, Sharma, Pankaj, Sudlow, Cathie LM, Rannikmae, Kristiina, Schmidt, Reinhold, Slowik, Agnieszka, Pera, Joanna, Thijs, Vincent NS, Lindgren, Arne G, Ilinca, Andreea, Melander, Olle, Engstrom, Gunnar, Rexrode, Kathryn M, Rothwell, Peter M, Stanne, Tara M, Johnson, Julie A, Danesh, John, Butterworth, Adam S, Heitsch, Laura, Boncoraglio, Giorgio B, Kubo, Michiaki, Pezzini, Alessandro, Rolfs, Arndt, Giese, Anne-Katrin, Weir, David, Ross, Owen A, Lemmons, Robin, Soderholm, Martin, Cushman, Mary, Jood, Katarina, McDonough, Caitrin W, Bell, Steven, Linkohr, Birgit, Lee, Tsong-Hai, Putaala, Jukka, Anderson, Christopher D, Lopez, Oscar L, Jian, Xueqiu, Schminke, Ulf, Cullell, Natalia, Delgado, Pilar, Ibanez, Laura, Krupinski, Jerzy, Lioutas, Vasileios, Matsuda, Koichi, Montaner, Joan, Muino, Elena, Roquer, Jaume, Sarnowski, Chloe, Sattar, Naveed, Sibolt, Gerli, Teumer, Alexander, Rutten-Jacobs, Loes, Kanai, Masahiro, Gretarsdottir, Solveig, Rost, Natalia S, Yusuf, Salim, Almgren, Peter, Ay, Hakan, Bevan, Steve, Brown, Robert D, Carrera, Caty, Buring, Julie E, Chen, Wei-Min, Cotlarciuc, Ioana, de Bakker, Paul IW, DeStefano, Anita L, den Hoed, Marcel, Duan, Qing, Engelter, Stefan T, Falcone, Guido J, Gustafsson, Stefan, Hassan, Ahamad, Holliday, Elizabeth G, Howard, George, Hsu, Fang-Chi, Ingelsson, Erik, Harris, Tamara B, Kissela, Brett M, Kleindorfer, Dawn O, Langenberg, Claudia, Lemmens, Robin, Leys, Didier, Lin, Wei-Yu, Lorentzen, Erik, Magnusson, Patrik K, McArdle, Patrick F, Pulit, Sara L, Rice, Kenneth, Sakaue, Saori, Sapkota, Bishwa R, Tanislav, Christian, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tzourio, Christophe, van Duijn, Cornelia M, Walters, Matthew, Wareham, Nicholas J, Amin, Najaf, Aparicio, Hugo J, Attia, John, Beiser, Alexa S, Berr, Claudine, Bustamante, Mariana, Caso, Valeria, Choi, Seung Hoan, Chowhan, Ayesha, Dartigues, Jean-Francois, Delavaran, Hossein, Dorr, Marcus, Ford, Ian, Gurpreet, Wander S, Hamsten, Anders, Hozawa, Atsushi, Ingelsson, Martin, Iwasaki, Motoki, Kaffashian, Sara, Kalra, Lalit, Kjartansson, Olafur, Kloss, Manja, Labovitz, Daniel L, Laurie, Cathy C, Li, Linxin, Lind, Lars, Lindgren, Cecilia M, Makoto, Hirata, Minegishi, Naoko, Morris, Andrew P, Muller-Nurasyid, Martina, Norrving, Bo, Ogishima, Soichi, Parati, Eugenio A, Pedersen, Nancy L, Perola, Markus, Jousilahti, Pekka, Pileggi, Silvana, Rabionet, Raquel, Riba-Llena, Iolanda, Ribases, Marta, Romero, Jose R, Rudd, Anthony G, Sarin, Antti-Pekka, Sarju, Ralhan, Satoh, Mamoru, Sawada, Norie, Sigurdsson, Asgeir, Smith, Albert, Stine, O Colin, Stott, David J, Strauch, Konstantin, Takai, Takako, Tanaka, Hideo, Touze, Emmanuel, Tsugane, Shoichiro, Uitterlinden, Andre G, Valdimarsson, Einar M, van der Lee, Sven J, Wakai, Kenji, Williams, Stephen R, Wolfe, Charles DA, Wong, Quenna, Yamaji, Taiki, Sanghera, Dharambir K, Stefansson, Kari, Martinez-Majander, Nicolas, Sobue, Kenji, Soriano-Tarraga, Carolina, Volzke, Henry, Akpa, Onoja, Sarfo, Fred S, Akpalu, Albert, Obiako, Reginald, Wahab, Kolawole, Osaigbovo, Godwin, Owolabi, Lukman, Komolafe, Morenikeji, Jenkins, Carolyn, Arulogun, Oyedunni, Ogbole, Godwin, Adeoye, Abiodun M, Akinyemi, Joshua, Agunloye, Atinuke, Fakunle, Adekunle G, Uvere, Ezinne, Olalere, Abimbola, Adebajo, Olayinka J, Chen, Junshi, Clarke, Robert, Collins, Rory, Guo, Yu, Wang, Chen, Lv, Jun, Peto, Richard, Chen, Yiping, Fairhurst-Hunter, Zammy, Hill, Michael, Pozarickij, Alfred, Schmidt, Dan, Stevens, Becky, Turnbull, Iain, Yu, Canqing, Nagai, Akiko, Murakami, Yoishinori, Shiroma, Eric J, Sigurdsson, Sigurdur, Ghanbari, Mohsen, Boerwinkle, Eric, Fongang, Bernard, Wang, Ruiqi, Ikram, Mohammad K, Volker, Uwe, de Laat, Karlijn F, van Norden, Anouk GW, de Kort, Paul L, Vermeer, Sarah E, Brouwers, Paul JAM, Gons, Rob AR, den Heijer, Tom, van Dijk, Gert W, van Rooij, Frank GW, Aamodt, Anne H, Skogholt, Anne H, Willer, Cristen J, Heuch, Ingrid, Hagen, Knut, Fritsche, Lars G, Pedersen, Linda M, Ellekjaer, Hanne, Zhou, Wei, Martinsen, Amy E, Kristoffersen, Espen S, Thomas, Laurent F, Kleinschnitz, Christoph, Frantz, Stefan, Ungethum, Kathrin, Gallego-Fabrega, Cristina, Lledos, Miquel, Llucia-Carol, Laia, Sobrino, Tomas, Campos, Francisco, Castillo, Jose, Freijo, Marimar, Arenillas, Juan Francisco, Obach, Victor, Alvarez-Sabin, Jose, Molina, Carlos A, Ribo, Marc, Munoz-Narbona, Lucia, Lopez-Cancio, Elena, Millan, Monica, Diaz-Navarro, Rosa, Vives-Bauza, Cristofol, Serrano-Heras, Gemma, Segura, Tomas, Dhar, Rajat, Delgado-Mederos, Raquel, Prats-Sanchez, Luis, Camps-Renom, Pol, Blay, Natalia, Sumoy, Lauro, Marti-Fabregas, Joan, Schnohr, Peter, Jensen, Gorm B, Benn, Marianne, Afzal, Shoaib, Kamstrup, Pia R, van Setten, Jessica, van der Laan, Sander W, Vonk, Jet MJ, Kim, Bong-Jo, Curtze, Sami, Tiainen, Marjaana, Kinnunen, Janne, Menon, Vilas, Sung, Yun Ju, Yang, Chengran, Saillour-Glenisson, Florence, Gravel, Simon, Millwood, Iona Y, Gieger, Christian, Ninomiya, Toshiharu, Grabe, Hans J, Jukema, J Wouter, Rissanen, Ina L, Strbian, Daniel, Kim, Young Jin, Chen, Pei-Hsin, Mayerhofer, Ernst, Howson, Joanna MM, Adams, Hieab, Wassertheil-Smoller, Sylvia, Christensen, Kaare, Ikram, Mohammad A, Rundek, Tatjana, Worrall, Bradford B, Lathrop, G Mark, Riaz, Moeen, Simonsick, Eleanor M, Korv, Janika, Franca, Paulo HC, Zand, Ramin, Prasad, Kameshwar, Frikke-Schmidt, Ruth, Liman, Thomas, Haeusler, Karl Georg, Ruigrok, Ynte M, Heuschmann, Peter Ulrich, Longstreth, WT, Jung, Keum Ji, Bastarache, Lisa, Pare, Guillaume, Damrauer, Scott M, Chasman, Daniel I, Rotter, Jerome I, Zwart, John-Anker, Niiranen, Teemu J, Fornage, Myriam, Liaw, Yung-Po, Seshadri, Sudha, Fernandez-Cadenas, Israel, Walters, Robin G, Ruff, Christian T, Owolabi, Mayowa O, Huffman, Jennifer E, Milani, Lili, Kamatani, Yoichiro, Dichgans, Martin, and Debette, Stephanie
Abstract: Previous genome-wide association studies (GWASs) of stroke — the second leading cause of death worldwide — were conducted predominantly in populations of European ancestry1,2. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated (P < 0.05). Effect sizes were highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis3, and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN) and variants (such as at GRK5 and NOS3). Using a three-pronged approach4, we provide genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWASs with vascular-risk factor GWASs (integrative polygenic scores) strongly predicted ischaemic stroke in populations of European, East Asian and African ancestry5. Stroke genetic risk scores were predictive of ischaemic stroke independent of clinical risk factors in 52,600 clinical-trial participants with cardiometabolic disease. Our results provide insights to inform biology, reveal potential drug targets and derive genetic risk prediction tools across ancestries.
Published: 2022

11. Genetic variation at 16q24.2 is associated with small vessel stroke

Author: Traylor, Matthew, Malik, Rainer, Nalls, Mike A., Cotlarciuc, Ioana, Radmanesh, Farid, Thorleifsson, Gudmar, Hanscombe, Ken B., Langefeld, Carl, Saleheen, Danish, Rost, Natalia S., Yet, Idil, Spector, Tim D., Bell, Jordana T., Hannon, Eilis, Mill, Jonathan, Chauhan, Ganesh, Debette, Stephanie, Bis, Joshua C., Longstreth, W.T., Jr., Ikram, M. Arfan, Launer, Lenore J., Seshadri, Sudha, Hamilton‐Bruce, Monica Anne, Jimenez‐Conde, Jordi, Cole, John W., Schmidt, Reinhold, Słowik, Agnieszka, Lemmens, Robin, Lindgren, Arne, Melander, Olle, Grewal, Raji P., Sacco, Ralph L., Rundek, Tatjana, Rexrode, Kathryn, Arnett, Donna K., Johnson, Julie A., Benavente, Oscar R., Wasssertheil‐Smoller, Sylvia, Lee, Jin‐Moo, Pulit, Sara L., Wong, Quenna, Rich, Stephen S., de Bakker, Paul I.W., McArdle, Patrick F., Woo, Daniel, Anderson, Christopher D., Xu, Huichun, Heitsch, Laura, Fornage, Myriam, Jern, Christina, Stefansson, Kari, Thorsteinsdottir, Unnur, Gretarsdottir, Solveig, Lewis, Cathryn M., Sharma, Pankaj, Sudlow, Cathie L.M., Rothwell, Peter M., Boncoraglio, Giorgio B., Thijs, Vincent, Levi, Chris, Meschia, James F., Rosand, Jonathan, Kittner, Steven J., Mitchell, Braxton D., Dichgans, Martin, Worrall, Bradford B., and Markus, Hugh S.
Published: 2017
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12. Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE Collaboration): a meta-analysis of genome-wide association studies

Author: Traylor, Matthew, Farrall, Martin, Holliday, Elizabeth G, Sudlow, Cathie, Hopewell, Jemma C, Cheng, Yu-Ching, Fornage, Myriam, Ikram, M Arfan, Malik, Rainer, Bevan, Steve, Thorsteinsdottir, Unnur, Nalls, Mike A, Longstreth, WT, Wiggins, Kerri L, Yadav, Sunaina, Parati, Eugenio A, DeStefano, Anita L, Worrall, Bradford B, Kittner, Steven J, Khan, Muhammad Saleem, Reiner, Alex P, Helgadottir, Anna, Achterberg, Sefanja, Fernandez-Cadenas, Israel, Abboud, Sherine, Schmidt, Reinhold, Walters, Matthew, Chen, Wei-Min, Ringelstein, E Bernd, O'Donnell, Martin, Ho, Weang Kee, Pera, Joanna, Lemmens, Robin, Norrving, Bo, Higgins, Peter, Benn, Marianne, Sale, Michele, Kuhlenbäumer, Gregor, Doney, Alexander S F, Vicente, Astrid M, Delavaran, Hossein, Algra, Ale, Davies, Gail, Oliveira, Sofia A, Palmer, Colin N A, Deary, Ian, Schmidt, Helena, Pandolfo, Massimo, Montaner, Joan, Carty, Cara, de Bakker, Paul I W, Kostulas, Konstantinos, Ferro, Jose M, van Zuydam, Natalie R, Valdimarsson, Einar, Nordestgaard, Børge G, Lindgren, Arne, Thijs, Vincent, Slowik, Agnieszka, Saleheen, Danish, Paré, Guillaume, Berger, Klaus, Thorleifsson, Gudmar, Hofman, Albert, Mosley, Thomas H, Mitchell, Braxton D, Furie, Karen, Clarke, Robert, Levi, Christopher, Seshadri, Sudha, Gschwendtner, Andreas, Boncoraglio, Giorgio B, Sharma, Pankaj, Bis, Joshua C, Gretarsdottir, Solveig, Psaty, Bruce M, Rothwell, Peter M, Rosand, Jonathan, Meschia, James F, Stefansson, Kari, Dichgans, Martin, and Markus, Hugh S
Published: 2012
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13. Clinical Pregenetic Screening for Stroke Monogenic Diseases: Results From Lombardia GENS Registry

Author: Bersano, Anna, Markus, Hugh Stephen, Quaglini, Silvana, Arbustini, Eloisa, Lanfranconi, Silvia, Micieli, Giuseppe, Boncoraglio, Giorgio B., Taroni, Franco, Gellera, Cinzia, Baratta, Silvia, Penco, Silvana, Mosca, Lorena, Grasso, Maurizia, Carrera, Paola, Ferrari, Maurizio, Cereda, Cristina, Grieco, Gaetano, Corti, Stefania, Ronchi, Dario, Bassi, Maria Teresa, Obici, Laura, Parati, Eugenio A., Pezzini, Alessando, De Lodovici, Maria Luisa, Verrengia, Elena P., Bono, Giorgio, Mazucchelli, Francesca, Zarcone, Davide, Calloni, Maria Vittoria, Perrone, Patrizia, Bordo, Bianca Maria, Colombo, Antonio, Padovani, Alessandro, Cavallini, Anna, Beretta, Simone, Ferrarese, Carlo, Motto, Cristina, Agostoni, Elio, Molini, Graziella, Sasanelli, Francesco, Corato, Manuel, Marcheselli, Simona, Sessa, Maria, Comi, Giancarlo, Checcarelli, Nicoletta, Guidotti, Mario, Uccellini, Davide, Capitani, Erminio, Tancredi, Lucia, Arnaboldi, Marco, Incorvaia, Barbara, Tadeo, Carlo Sebastiano, Fusi, Laura, Grampa, Giampiero, Merlini, Giampaolo, Trobia, Nadia, Comi, Giacomo Pietro, Braga, Massimiliano, Vitali, Paolo, Baron, Pierluigi, Grond-Ginsbach, Caspar, and Candelise, Livia
Published: 2016
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14. Genome-Wide Association Analysis of Young-Onset Stroke Identifies a Locus on Chromosome 10q25 Near HABP2

Author: Cheng, Yu-Ching, Stanne, Tara M., Giese, Anne-Katrin, Ho, Weang Kee, Traylor, Matthew, Amouyel, Philippe, Holliday, Elizabeth G., Malik, Rainer, Xu, Huichun, Kittner, Steven J., Cole, John W., O’Connell, Jeffrey R., Danesh, John, Rasheed, Asif, Zhao, Wei, Engelter, Stefan, Grond-Ginsbach, Caspar, Kamatani, Yoichiro, Lathrop, Mark, Leys, Didier, Thijs, Vincent, Metso, Tiina M., Tatlisumak, Turgut, Pezzini, Alessandro, Parati, Eugenio A., Norrving, Bo, Bevan, Steve, Rothwell, Peter M., Sudlow, Cathie, Slowik, Agnieszka, Lindgren, Arne, Walters, Matthew R., Jannes, Jim, Shen, Jess, Crosslin, David, Doheny, Kimberly, Laurie, Cathy C., Kanse, Sandip M., Bis, Joshua C., Fornage, Myriam, Mosley, Thomas H., Hopewell, Jemma C., Strauch, Konstantin, Müller-Nurasyid, Martina, Gieger, Christian, Waldenberger, Melanie, Peters, Annette, Meisinger, Christine, Ikram, M. Arfan, Longstreth, W.T., Jr, Meschia, James F., Seshadri, Sudha, Sharma, Pankaj, Worrall, Bradford, Jern, Christina, Levi, Christopher, Dichgans, Martin, Boncoraglio, Giorgio B., Markus, Hugh S., Debette, Stephanie, Rolfs, Arndt, Saleheen, Danish, and Mitchell, Braxton D.
Published: 2016
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15. Genetic Overlap Between Diagnostic Subtypes of Ischemic Stroke

Author: Holliday, Elizabeth G., Traylor, Matthew, Malik, Rainer, Bevan, Steve, Falcone, Guido, Hopewell, Jemma C., Cheng, Yu-Ching, Cotlarciuc, Ioana, Bis, Joshua C., Boerwinkle, Eric, Boncoraglio, Giorgio B., Clarke, Robert, Cole, John W., Fornage, Myriam, Furie, Karen L., Ikram, M. Arfan, Jannes, Jim, Kittner, Steven J., Lincz, Lisa F., Maguire, Jane M., Meschia, James F., Mosley, Thomas H., Nalls, Mike A., Oldmeadow, Christopher, Parati, Eugenio A., Psaty, Bruce M., Rothwell, Peter M., Seshadri, Sudha, Scott, Rodney J., Sharma, Pankaj, Sudlow, Cathie, Wiggins, Kerri L., Worrall, Bradford B., Rosand, Jonathan, Mitchell, Braxton D., Dichgans, Martin, Markus, Hugh S., Levi, Christopher, Attia, John, and Wray, Naomi R.
Published: 2015
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16. Genetic Architecture of White Matter Hyperintensities Differs in Hypertensive and Nonhypertensive Ischemic Stroke

Author: Adib-Samii, Poneh, Devan, William, Traylor, Matthew, Lanfranconi, Silvia, Zhang, Cathy R., Cloonan, Lisa, Falcone, Guido J., Radmanesh, Farid, Fitzpatrick, Kaitlin, Kanakis, Allison, Rothwell, Peter M., Sudlow, Cathie, Boncoraglio, Giorgio B., Meschia, James F., Levi, Chris, Dichgans, Martin, Bevan, Steve, Rosand, Jonathan, Rost, Natalia S., and Markus, Hugh S.
Published: 2015
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17. Additional file 1 of Antiplatelet drugs for secondary prevention in patients with ischemic stroke or transient ischemic attack: a systematic review and network meta-analysis

Author: Del Giovane, Cinzia, Boncoraglio, Giorgio B., Bertù, Lorenza, Banzi, Rita, and Tramacere, Irene
Abstract: Additional file 1: Supplementary 1. Methodology details: secondary outcomes definition, study risk of bias and confidence in the evidence assessments. Supplementary 2. Characteristics of included studies table and references. Supplementary 3. Risk of bias summary table. Supplementary 4. Table of ongoing studies (last update December 2020). Supplementary 5. Network plots of evidence for secondary outcomes. Supplementary 6. Results of the pairwise meta-analyses for primary and secondary outcomes. Supplementary 7. Assessment of the confidence in the network estimates of each drug versus placebo/no treatment and versus aspirin ≤150 mg/day by outcome. Supplementary 8. SUCRA, probability to be the best and mean rank by outcome. Supplementary 9. Results from the assessment of incoherence by using global and local (side-split method) approaches for primary and secondary outcomes. Supplementary 10. Comparison-adjusted funnel plot for a network of interventions by outcome.
Published: 2021
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18. Antihypertensive Drugs for Secondary Prevention After Ischemic Stroke or Transient Ischemic Attack: A Systematic Review and Meta-Analysis

Author: Boncoraglio, Giorgio B., primary, Del Giovane, Cinzia, additional, and Tramacere, Irene, additional
Published: 2021
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19. Intracranial cavernoma and speckled lentiginous nevus: extending the spectrum of phakomatoses?

Author: Boncoraglio, Giorgio B., Parati, Eugenio A., Ciceri, Elisa, Rinaldi, Rosa, and Capella, Giovanni L.
Published: 2010
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20. Shared Genetic Susceptibility to Ischemic Stroke and Coronary Artery Disease: A Genome-Wide Analysis of Common Variants

Author: Dichgans, Martin, Malik, Rainer, König, Inke R., Rosand, Jonathan, Clarke, Robert, Gretarsdottir, Solveig, Thorleifsson, Gudmar, Mitchell, Braxton D., Assimes, Themistocles L., Levi, Christopher, O´Donnell, Christopher J., Fornage, Myriam, Thorsteinsdottir, Unnur, Psaty, Bruce M., Hengstenberg, Christian, Seshadri, Sudha, Erdmann, Jeanette, Bis, Joshua C., Peters, Annette, Boncoraglio, Giorgio B., März, Winfried, Meschia, James F., Kathiresan, Sekar, Ikram, M. Arfan, McPherson, Ruth, Stefansson, Kari, Sudlow, Cathie, Reilly, Muredach P., Thompson, John R., Sharma, Pankaj, Hopewell, Jemma C., Chambers, John C., Watkins, Hugh, Rothwell, Peter M., Roberts, Robert, Markus, Hugh S., Samani, Nilesh J., Farrall, Martin, Schunkert, Heribert, Gschwendtner, Andreas, Bevan, Steve, Chen, Yu-Ching, DeStefano, Anita L., Parati, Eugenio A., Quertermous, Tom, Ziegler, Andreas, Boerwinkle, Eric, Holm, Hilma, Fischer, Marcus, Kessler, Thorsten, Willenborg, Christina, Laaksonen, Reijo, Voight, Benjamin F., Stewart, Alexandre F.R., Rader, Daniel J., Hall, Alistair S., and Kooner, Jaspal S.
Published: 2014
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21. Stem Cell Transplantation for Ischemic Stroke [abstract]

Author: Boncoraglio, Giorgio B, Ranieri, Michela, Bersano, Anna, Parati, Eugenio A, and Del Giovane, Cinzia
Subjects: 610 Medicine & health, 360 Social problems & social services
Published: 2020
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22. 17q25 Locus Is Associated With White Matter Hyperintensity Volume in Ischemic Stroke, But Not With Lacunar Stroke Status

Author: Adib-Samii, Poneh, Rost, Natalia, Traylor, Matthew, Devan, William, Biffi, Alessandro, Lanfranconi, Silvia, Fitzpatrick, Kaitlin, Bevan, Steve, Kanakis, Allison, Valant, Valerie, Gschwendtner, Andreas, Malik, Rainer, Richie, Alexa, Gamble, Dale, Segal, Helen, Parati, Eugenio A., Ciusani, Emilio, Holliday, Elizabeth G., Maguire, Jane, Wardlaw, Joanna, Worrall, Bradford, Bis, Joshua, Wiggins, Kerri L., Longstreth, Will, Kittner, Steve J., Cheng, Yu-Ching, Mosley, Thomas, Falcone, Guido J., Furie, Karen L., Leiva-Salinas, Carlos, Lau, Benison C., Saleem Khan, Muhammed, Sharma, Pankaj, Fornage, Myriam, Mitchell, Braxton D., Psaty, Bruce M., Sudlow, Cathie, Levi, Christopher, Boncoraglio, Giorgio B., Rothwell, Peter M., Meschia, James, Dichgans, Martin, Rosand, Jonathan, and Markus, Hugh S.
Published: 2013
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23. Are Myocardial Infarction–Associated Single-Nucleotide Polymorphisms Associated With Ischemic Stroke?

Author: Cheng, Yu-Ching, Anderson, Christopher D., Bione, Silvia, Keene, Keith, Maguire, Jane M., Nalls, Michael, Rasheed, Asif, Zeginigg, Marion, Attia, John, Baker, Ross, Barlera, Simona, Biffi, Alessandro, Bookman, Ebony, Brott, Thomas G., Brown, Robert D., Jr, Chen, Fang, Chen, Wei-Min, Ciusani, Emilio, Cole, John W., Cortellini, Lynelle, Danesh, John, Doheny, Kimberly, Ferrucci, Luigi, Grazia Franzosi, Maria, Frossard, Philippe, Furie, Karen L., Golledge, Jonathan, Hankey, Graeme J., Hernandez, Dena, Holliday, Elizabeth G., Hsu, Fang-Chi, Jannes, Jim, Kamal, Ayeesha, Khan, Muhammad Saleem, Kittner, Steven J., Koblar, Simon A., Lewis, Martin, Lincz, Lisa, Lisa, Antonella, Matarin, Mar, Moscato, Pablo, Mychaleckyj, Josyf C., Parati, Eugenio A., Parolo, Silvia, Pugh, Elizabeth, Rost, Natalia S., Schallert, Michael, Schmidt, Helena, Scott, Rodney J., Sturm, Jonathan W., Yadav, Sunaina, Zaidi, Moazzam, Boncoraglio, Giorgio B., Levi, Christopher Royce, Meschia, James F., Rosand, Jonathan, Sale, Michele, Saleheen, Danish, Schmidt, Reinhold, Sharma, Pankaj, Worrall, Bradford, and Mitchell, Braxton D.
Published: 2012
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24. Stem Cell Transplantation for Ischemic Stroke

Author: Boncoraglio, Giorgio B., Bersano, Anna, Candelise, Livia, Reynolds, Brent A., and Parati, Eugenio A.
Published: 2011
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25. Stem Cell Transplantation for Ischemic Stroke

Author: Boncoraglio, Giorgio B., primary, Ranieri, Michela, additional, Bersano, Anna, additional, Parati, Eugenio A., additional, and Del Giovane, Cinzia, additional
Published: 2020
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26. Relative effects of LDL-C on ischemic stroke and coronary disease A Mendelian randomization study

Author: Valdes-Marquez, Elsa, Parish, Sarah, Clarke, Robert, Stari, Traiani, Worrall, Bradford B, Hopewell, Jemma C, Slowik, Agnieszka, Hofman, Albert, Algra, Ale, Reiner, Alex P, Doney, Alexander SF, Gschwendtner, Andreas, Ilinca, Andreea, Giese, Anne-Katrin, Lindgren, Arne, Vicente, Astrid M, Norrving, Bo, Nordestgaard, Borge G, Mitchell, Braxton D, Psaty, Bruce M, Carty, Cara L, Sudlow, Cathie LM, Anderson, Christopher, Levi, Christopher R, Satizabal, Claudia L, Palmer, Colin NA, Gamble, Dale M, Woo, Daniel, Saleheen, Danish, Ringelstein, Bernd E, Valdimarsson, Einar M, Holliday, Elizabeth G, Davies, Gail, Chauhan, Ganesh, Pasterkamp, Gerard, Boncoraglio, Giorgio B, Kuhlenbaeumer, Gregor, Thorleifsson, Gudmar, Falcone, Guido J, Pare, Guillaume, Schmidt, Helena, Delavaran, Hossein, Markus, Hugh S, Aparicio, Hugo J, Deary, Ian, Cotlarciuc, Ioana, Fernandez-Cadenas, Israel, Meschia, James F, Liu, Jingmin, Montaner, Joan, Pera, Joanna, Cole, John, Attia, John R, Rosand, Jonathan, Ferro, Jose M, Bis, Joshua C, Furie, Karen, Stefansson, Kari, Berger, Klaus, Kostulas, Konstantinos, Rannikmae, Kristiina, Ikram, Arfan M, Benn, Marianne, Dichgans, Martin, Pandolfo, Massimo, Traylor, Matthew, Walters, Matthew, Sale, Michele, Nalls, Michael A, Fornage, Myriam, van Zuydam, Natalie R, Sharma, Pankaj, Abrantes, Patricia, de Bakker, Paul IW, Higgins, Peter, Lichtner, Peter, Rothwell, Peter M, Amouyel, Philippe, Yang, Qiong, Malik, Rainer, Schmidt, Reinhold, Lemmens, Robin, van der Laan, Sander W, Pulit, Sara L, Abboud, Sherine, Oliveira, Sofia A, Gretarsdottir, Solveig, Debette, Stephanie, Williams, Stephen R, Bevan, Steve, Kittner, Steven J, Seshadri, Sudha, Mosley, Thomas, Battey, Thomas WK, Tatlisumak, Turgut, Thorsteinsdottir, Unnur, Thijs, Vincent NS, Longstreth, WT, Zhao, Wei, Chen, Wei-Min, and Cheng, Yu-Ching
Subjects: Science & Technology, STATIN THERAPY, DENSITY-LIPOPROTEIN-CHOLESTEROL, Clinical Neurology, HEART-DISEASE, SUBTYPES, PCSK9, Centre for Brain Research, REDUCTION, BMI, GENETIC-VARIANTS, RISK-FACTORS, Neurosciences & Neurology, Life Sciences & Biomedicine, METAANALYSIS
Abstract: OBJECTIVE: To examine the causal relevance of lifelong differences in low-density lipoprotein cholesterol (LDL-C) for ischemic stroke (IS) relative to that for coronary heart disease (CHD) using a Mendelian randomization approach. METHODS: We undertook a 2-sample Mendelian randomization, based on summary data, to estimate the causal relevance of LDL-C for risk of IS and CHD. Information from 62 independent genetic variants with genome-wide significant effects on LDL-C levels was used to estimate the causal effects of LDL-C for IS and IS subtypes (based on 12,389 IS cases from METASTROKE) and for CHD (based on 60,801 cases from CARDIoGRAMplusC4D). We then assessed the effects of LDL-C on IS and CHD for heterogeneity. RESULTS: A 1 mmol/L higher genetically determined LDL-C was associated with a 50% higher risk of CHD (odds ratio [OR] 1.49, 95% confidence interval [CI] 1.32-1.68, p = 1.1 × 10-8). By contrast, the causal effect of LDL-C was much weaker for IS (OR 1.12, 95% CI 0.96-1.30, p = 0.14; p for heterogeneity = 2.6 × 10-3) and, in particular, for cardioembolic stroke (OR 1.06, 95% CI 0.84-1.33, p = 0.64; p for heterogeneity = 8.6 × 10-3) when compared with that for CHD. CONCLUSIONS: In contrast with the consistent effects of LDL-C-lowering therapies on IS and CHD, genetic variants that confer lifelong LDL-C differences show a weaker effect on IS than on CHD. The relevance of etiologically distinct IS subtypes may contribute to the differences observed. ispartof: NEUROLOGY vol:92 issue:11 pages:E1176-E1187 ispartof: location:United States status: published
Published: 2019

27. Supplementary_Table – Supplemental material for Is Period3 Genotype Associated With Sleep and Recovery in Patients With Disorders of Consciousness?

Author: Bedini, Gloria, Bersano, Anna, Sebastiano, Davide Rossi, Sattin, Davide, Ciaraffa, Francesca, Tosetti, Valentina, Brenna, Greta, Franceschetti, Silvana, Ciusani, Emilio, Leonardi, Matilde, Vela-Gomez, Jesus, Boncoraglio, Giorgio B., and Parati, Eugenio A.
Subjects: FOS: Clinical medicine, 110308 Geriatrics and Gerontology, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract: Supplemental material, Supplementary_Table for Is Period3 Genotype Associated With Sleep and Recovery in Patients With Disorders of Consciousness? by Gloria Bedini, Anna Bersano, Davide Rossi Sebastiano, Davide Sattin, Francesca Ciaraffa, Valentina Tosetti, Greta Brenna, Silvana Franceschetti, Emilio Ciusani, Matilde Leonardi, Jesus Vela-Gomez, Giorgio B. Boncoraglio and Eugenio A. Parati in Neurorehabilitation and Neural Repair
Published: 2019
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28. Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes (Nature Genetics, (2018), 50, 4, (524-537), 10.1038/s41588-018-0058-3)

Author: Malik, Rainer, Chauhan, Ganesh, Traylor, Matthew, Sargurupremraj, Muralidharan, Okada, Yukinori, Mishra, Aniket, Rutten-Jacobs, Loes, Giese, Anne-Katrin, van der Laan, Sander W., Gretarsdottir, Solveig, Anderson, Christopher D., Chong, Michael, Adams, Hieab H. H., Ago, Tetsuro, Almgren, Peter, Amouyel, Philippe, Ay, Hakan, Bartz, Traci M., Benavente, Oscar R., Bevan, Steve, Boncoraglio, Giorgio B., Brown, Robert D., Butterworth, Adam S., Carrera, Caty, Carty, Cara L., Chasman, Daniel I., Chen, Wei-Min, Cole, John W., Correa, Adolfo, Cotlarciuc, Ioana, Cruchaga, Carlos, Danesh, John, de Bakker, Paul I. W., DeStefano, Anita L., den Hoed, Marcel, Duan, Qing, Engelter, Stefan T., Falcone, Guido J., Gottesman, Rebecca F., Grewal, Raji P., Gudnason, Vilmundur, Gustafsson, Stefan, Haessler, Jeffrey, Harris, Tamara B., Hassan, Ahamad, Havulinna, Aki S., and van der Lee, Sven J.
Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Published: 2019

29. An Effect of the PAI-1 4G/5G Polymorphism on Cholesterol Levels May Explain Conflicting Associations with Myocardial Infarction and Stroke

Author: Boncoraglio, Giorgio B., Bodini, Antonella, Brambilla, Carla, Carriero, Maria Rita, Ciusani, Emilio, and Parati, Eugenio A.
Published: 2006

30. Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting

Author: Chauhan Ganesh, Adams Hieab H. H., Satizabal Claudia L., Bis Joshua C., Teumer Alexander, Sargurupremraj Muralidharan, Hofer Edith, Trompet Stella, Hilal Saima, Smith Albert Vernon, Jian Xueqiu, Malik Rainer, Traylor Matthew, Pulit Sara L., Amouyel Philippe, Mazoyer Bernard, Zhu Yi-Cheng, Kaffashian Sara, Schilling Sabrina, Beecham Gary W., Montine Thomas J., Schellenberg Gerard D., Kjartansson Olafur, Gudnason Vilmundur, Knopman David S., Griswold Michael E., Windham B. Gwen, Gottesman Rebecca F., Mosley Thomas H., Schmidt Reinhold, Saba Yasaman, Schmidt Helena, Takeuchi Fumihiko, Yamaguchi Shuhei, Nabika, Toru, Kato Norihiro, Rajan Kumar B., Aggarwal Neelum T., De Jager Philip L., Evans Denis A., Psaty Bruce M., Rotter Jerome I., Rice Kenneth, Lopez Oscar L., Liao Jiemin, Chen Christopher, Cheng Ching-Yu, Wong Tien Y., Ikram Mohammad K., van der Lee Sven J., Amin Najaf, Chouraki Vincent, DeStefano Anita L., Aparicio Hugo J., Romero Jose R., Maillard Pauline, DeCarli Charles, Wardlaw Joanna M., Hernandez Maria del C. Valdes, Luciano Michelle, Liewald David, Deary Ian J., Starr John M., Bastin Mark E., Maniega Susana Munoz, Slagboom P. Eline, Beekman Marian, Deelen Joris, Uh Hae-Won, Lemmens Robin, Brodaty Henry, Wright Margaret J., Ames David, Boncoraglio Giorgio B., Hopewell Jemma C., Beecham Ashley H., Blanton Susan H., Wright Clinton B., Sacco Ralph L., Wen Wei, Thalamuthu Anbupalam, Armstrong Nicola J., Chong Elizabeth, Schofield Peter R., Kwok John B., van der Grond Jeroen, Stott David J., Ford Ian, Jukema J. Wouter, Vernooij Meike W., Hofman Albert, Uitterlinden Andre G., van der Lugt Aad, Wittfeld Katharina, Grabe Hans J., Hosten Norbert, von Sarnowski Bettina, Voelker Uwe, Levi Christopher, Jimenez-Conde Jordi, Sharma Pankaj, Sudlow Cathie L. M., Rosand Jonathan, Woo Daniel, Cole John W., Meschia James F., Slowik Agnieszka, Thijs Vincent, Lindgren Arne, Melander Olle, Grewal Raji P., Rundek Tatjana, Rexrode Kathy, Rothwell Peter M., Arnett Donna K., Jern Christina, Johnson Julie A., Benavente Oscar R., Wasssertheil-Smoller Sylvia, Lee Jin-Moo, Wong Quenna, Mitchell Braxton D., Rich Stephen S., McArdle Patrick F., Geerlings Mirjam I., van der Graaf Yolanda, de Bakker Paul I. W., Asselbergs Folkert W., Srikanth Velandai, Thomson Russell, McWhirter Rebekah, Moran Chris, Callisaya Michele, Thanh Phan, Rutten-Jacobs Loes C. A., Bevan Steve, Tzourio Christophe, Mather Karen A., Sachdev Perminder S., van Duijn Cornelia M., Worrall Bradford B., Dichgans Martin, Kittner Steven J., Markus Hugh S., Ikram Mohammad A., Fornage Myriam, Launer Lenore J., Seshadri Sudha, Longstreth W. T. Jr., Debette Stephanie, Chauhan Ganesh, Adams Hieab H. H., Satizabal Claudia L., Bis Joshua C., Teumer Alexander, Sargurupremraj Muralidharan, Hofer Edith, Trompet Stella, Hilal Saima, Smith Albert Vernon, Jian Xueqiu, Malik Rainer, Traylor Matthew, Pulit Sara L., Amouyel Philippe, Mazoyer Bernard, Zhu Yi-Cheng, Kaffashian Sara, Schilling Sabrina, Beecham Gary W., Montine Thomas J., Schellenberg Gerard D., Kjartansson Olafur, Gudnason Vilmundur, Knopman David S., Griswold Michael E., Windham B. Gwen, Gottesman Rebecca F., Mosley Thomas H., Schmidt Reinhold, Saba Yasaman, Schmidt Helena, Takeuchi Fumihiko, Yamaguchi Shuhei, Nabika, Toru, Kato Norihiro, Rajan Kumar B., Aggarwal Neelum T., De Jager Philip L., Evans Denis A., Psaty Bruce M., Rotter Jerome I., Rice Kenneth, Lopez Oscar L., Liao Jiemin, Chen Christopher, Cheng Ching-Yu, Wong Tien Y., Ikram Mohammad K., van der Lee Sven J., Amin Najaf, Chouraki Vincent, DeStefano Anita L., Aparicio Hugo J., Romero Jose R., Maillard Pauline, DeCarli Charles, Wardlaw Joanna M., Hernandez Maria del C. Valdes, Luciano Michelle, Liewald David, Deary Ian J., Starr John M., Bastin Mark E., Maniega Susana Munoz, Slagboom P. Eline, Beekman Marian, Deelen Joris, Uh Hae-Won, Lemmens Robin, Brodaty Henry, Wright Margaret J., Ames David, Boncoraglio Giorgio B., Hopewell Jemma C., Beecham Ashley H., Blanton Susan H., Wright Clinton B., Sacco Ralph L., Wen Wei, Thalamuthu Anbupalam, Armstrong Nicola J., Chong Elizabeth, Schofield Peter R., Kwok John B., van der Grond Jeroen, Stott David J., Ford Ian, Jukema J. Wouter, Vernooij Meike W., Hofman Albert, Uitterlinden Andre G., van der Lugt Aad, Wittfeld Katharina, Grabe Hans J., Hosten Norbert, von Sarnowski Bettina, Voelker Uwe, Levi Christopher, Jimenez-Conde Jordi, Sharma Pankaj, Sudlow Cathie L. M., Rosand Jonathan, Woo Daniel, Cole John W., Meschia James F., Slowik Agnieszka, Thijs Vincent, Lindgren Arne, Melander Olle, Grewal Raji P., Rundek Tatjana, Rexrode Kathy, Rothwell Peter M., Arnett Donna K., Jern Christina, Johnson Julie A., Benavente Oscar R., Wasssertheil-Smoller Sylvia, Lee Jin-Moo, Wong Quenna, Mitchell Braxton D., Rich Stephen S., McArdle Patrick F., Geerlings Mirjam I., van der Graaf Yolanda, de Bakker Paul I. W., Asselbergs Folkert W., Srikanth Velandai, Thomson Russell, McWhirter Rebekah, Moran Chris, Callisaya Michele, Thanh Phan, Rutten-Jacobs Loes C. A., Bevan Steve, Tzourio Christophe, Mather Karen A., Sachdev Perminder S., van Duijn Cornelia M., Worrall Bradford B., Dichgans Martin, Kittner Steven J., Markus Hugh S., Ikram Mohammad A., Fornage Myriam, Launer Lenore J., Seshadri Sudha, Longstreth W. T. Jr., and Debette Stephanie
Published: 2019

31. Serum magnesium and calcium levels in relation to ischemic stroke:Mendelian randomization study

Author: Larsson, Susanna C., Traylor, Matthew, Burgess, Stephen, Boncoraglio, Giorgio B., Jern, Christina, Michaëlsson, Karl, Larsson, Susanna C., Traylor, Matthew, Burgess, Stephen, Boncoraglio, Giorgio B., Jern, Christina, and Michaëlsson, Karl
Abstract: ObjectiveTo determine whether serum magnesium and calcium concentrations are causally associated with ischemic stroke or any of its subtypes using the mendelian randomization approach.MethodsAnalyses were conducted using summary statistics data for 13 single-nucleotide polymorphisms robustly associated with serum magnesium (n = 6) or serum calcium (n = 7) concentrations. The corresponding data for ischemic stroke were obtained from the MEGASTROKE consortium (34,217 cases and 404,630 noncases).ResultsIn standard mendelian randomization analysis, the odds ratios for each 0.1 mmol/L (about 1 SD) increase in genetically predicted serum magnesium concentrations were 0.78 (95% confidence interval [CI] 0.69-0.89; p = 1.3 × 10-4) for all ischemic stroke, 0.63 (95% CI 0.50-0.80; p = 1.6 × 10-4) for cardioembolic stroke, and 0.60 (95% CI 0.44-0.82; p = 0.001) for large artery stroke; there was no association with small vessel stroke (odds ratio 0.90, 95% CI 0.67-1.20; p = 0.46). Only the association with cardioembolic stroke was robust in sensitivity analyses. There was no association of genetically predicted serum calcium concentrations with all ischemic stroke (per 0.5 mg/dL [about 1 SD] increase in serum calcium: odds ratio 1.03, 95% CI 0.88-1.21) or with any subtype.ConclusionsThis study found that genetically higher serum magnesium concentrations are associated with a reduced risk of cardioembolic stroke but found no significant association of genetically higher serum calcium concentrations with any ischemic stroke subtype.
Published: 2019

32. Genetic Variation at 16q24.2 is associated with small vessel stroke:16q24.2 and small vessel stroke

Author: Traylor, Matthew, Malik, Rainer, Nalls, Mike A., Cotlarciuc, Ioana, Radmanesh, Farid, Thorleifsson, Gudmar, Hanscombe, Ken B., Langefeld, Carl, Saleheen, Danish, Rost, Natalia S., Yet, Idil, Spector, Tim D., Bell, Jordana T., Hannon, Eilis, Mill, Jonathan, Chauhan, Ganesh, Debette, Stephanie, Bis, Joshua C., Longstreth, Wt, Ikram, M. Arfan, Launer, Lenore J., Seshadri, Sudha, Jimenez-conde, Jordi, Cole, John W., Schmidt, Reinhold, Słowik, Agnieszka, Lemmens, Robin, Lindgren, Arne, Melander, Olle, Grewal, Raji P., Sacco, Ralph L., Rundek, Tatjana, Rexrode, Kathryn, Arnett, Donna K., Johnson, Julie A., Benavente, Oscar R., Wasssertheil-smoller, Sylvia, Lee, Jin-moo, Pulit, Sara L., Wong, Quenna, Rich, Stephen S., De Bakker, Paul I.w., Mcardle, Patrick F., Woo, Daniel, Anderson, Christopher D., Xu, Huichun, Heitsch, Laura, Fornage, Myriam, Jern, Christina, Stefansson, Kari, Thorsteinsdottir, Unnur, Gretarsdottir, Solveig, Lewis, Cathryn M., Sharma, Pankaj, Sudlow, Catherine, Rothwell, Peter M., Boncoraglio, Giorgio B., Thijs, Vincent, Levi, Chris, Meschia, James F., Rosand, Jonathan, Kittner, Steven J., Mitchell, Braxton D., Dichgans, Martin, Worrall, Bradford B., and Markus, Hugh S.
Abstract: Objective: Genome-wide association studies (GWAS) have been successful at identifying associations with stroke and stroke subtypes, but have not yet identified any associations solely with small vessel stroke (SVS). SVS comprises a quarter of all ischaemic stroke and is a major manifestation of cerebral small vessel disease, the primary cause of vascular cognitive impairment. Studies across neurological traits have shown younger onset cases have an increased genetic burden. We leveraged this increased genetic burden by performing an age-at-onset informed GWAS meta-analysis, including a large younger onset SVS population, to identify novel associations with stroke.Methods: We used a three-stage age-at-onset informed GWAS to identify novel genetic variants associated with stroke. On identifying a novel locus associated with SVS, we assessed its influence on other small vessel disease phenotypes, as well as on mRNA expression of nearby genes, and on DNA methylation of nearby CpG sites in whole blood and in the fetal brain.Results: We identified an association with SVS in 4,203 cases and 50,728 controls on chromosome 16q24.2 (OR(95% CI)=1.16(1.10-1.22); p=3.2x10−9). The lead SNP (rs12445022) was also associated with cerebral white matter hyperintensities (OR(95% CI)=1.10(1.05-1.16); p=5.3x10−5; N=3,670), but not intracerebral haemorrhage (OR(95% CI)=0.97(0.84-1.12); p=0.71; 1,545 cases, 1,481 controls). rs12445022 is associated with mRNA expression of ZCCHC14 in arterial tissues (p=9.4x10−7), and DNA methylation at probe cg16596957 in whole blood (p=5.3x10−6).Interpretation: 16q24.2 is associated with SVS. Associations of the locus with expression of ZCCHC14 and DNA methylation suggest the locus acts through changes to regulatory elements. This article is protected by copyright. All rights reserved.
Published: 2016

33. Intravenous infusion of human bone marrow mesenchymal stromal cells promotes functional recovery and neuroplasticity after ischemic stroke in mice

Author: Sammali, Eliana, primary, Alia, Claudia, additional, Vegliante, Gloria, additional, Colombo, Valentina, additional, Giordano, Nadia, additional, Pischiutta, Francesca, additional, Boncoraglio, Giorgio B., additional, Barilani, Mario, additional, Lazzari, Lorenza, additional, Caleo, Matteo, additional, De Simoni, Maria-Grazia, additional, Gaipa, Giuseppe, additional, Citerio, Giuseppe, additional, and Zanier, Elisa R., additional
Published: 2017
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34. Protection of Brain Injury by Amniotic Mesenchymal Stromal Cell-Secreted Metabolites

Author: Pischiutta, Francesca, primary, Brunelli, Laura, additional, Romele, Pietro, additional, Silini, Antonietta, additional, Sammali, Eliana, additional, Paracchini, Lara, additional, Marchini, Sergio, additional, Talamini, Laura, additional, Bigini, Paolo, additional, Boncoraglio, Giorgio B., additional, Pastorelli, Roberta, additional, De Simoni, Maria-Grazia, additional, Parolini, Ornella, additional, and Zanier, Elisa R., additional
Published: 2016
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35. No additional prognostic value of genetic information in the prediction of vascular events after cerebral ischemia of arterial origin : The PROMISe study

Author: Achterberg, Sefanja, Kappelle, L. Jaap, De Bakker, Paul I W, Traylor, Matthew, Algra, Ale, Van Der Graaf, Y., Grobbee, D. E., Rutten, G. E H M, Visseren, F. L J, Moll, F. L., Mali, W. P T M, Doevendans, P. A., Martin, Farrall, Holliday, Elizabeth G., Sudlow, Cathie, Hopewell, Jemma C., Cheng, Yu Ching, Fornage, Myriam, Ikram, M. Arfan, Malik, Rainer, Bevan, Steve, Thorsteinsdottir, Unnur, DeStefano, Anita L., Worrall, Bradford B., Reiner, Alex P., Mitchell, Braxton D., Clarke, Robert, Levi, Christopher, Seshadri, Sudha, Boncoraglio, Giorgio B., Sharma, Pankaj, Bis, Joshua C., Gretarsdottir, Solveig, Psaty, Bruce M., Rothwell, Peter M., Rosand, Jonathan, Meschia, James F., Stefansson, Kari, Dichgans, Martin, and Markus, Hugh S.
Subjects: Male, medicine.medical_specialty, Genotype, Ischemia, lcsh:Medicine, Single-nucleotide polymorphism, Genome-wide association study, Biochemistry, Polymorphism, Single Nucleotide, Brain Ischemia, Risk Factors, Internal medicine, medicine, Genetic predisposition, Humans, Myocardial infarction, Vascular Diseases, lcsh:Science, Aged, Medicine(all), Multidisciplinary, Receiver operating characteristic, Agricultural and Biological Sciences(all), business.industry, Biochemistry, Genetics and Molecular Biology(all), Incidence, lcsh:R, Arteries, Cerebral Infarction, Middle Aged, medicine.disease, Prognosis, Human genetics, Confidence interval, 3. Good health, Surgery, Stroke, ROC Curve, Area Under Curve, Cardiology, Female, lcsh:Q, business, Genetics and Molecular Biology(all), Research Article, Genome-Wide Association Study
Abstract: Background: Patients who have suffered from cerebral ischemia have a high risk of recurrent vascular events. Predictive models based on classical risk factors typically have limited prognostic value. Given that cerebral ischemia has a heritable component, genetic information might improve performance of these risk models. Our aim was to develop and compare two models: one containing traditional vascular risk factors, the other also including genetic information. Methods and Results: We studied 1020 patients with cerebral ischemia and genotyped them with the Illumina Immunochip. Median follow-up time was 6.5 years; the annual incidence of new ischemic events (primary outcome, n=198) was 3.0%. The prognostic model based on classical vascular risk factors had an area under the receiver operating characteristics curve (AUC-ROC) of 0.65 (95% confidence interval 0.61-0.69). When we added a genetic risk score based on prioritized SNPs from a genome-wide association study of ischemic stroke (using summary statistics from the METASTROKE study which included 12389 cases and 62004 controls), the AUC-ROC remained the same. Similar results were found for the secondary outcome ischemic stroke. Conclusions: We found no additional value of genetic information in a prognostic model for the risk of ischemic events in patients with cerebral ischemia of arterial origin. This is consistent with a complex, polygenic architecture, where many genes of weak effect likely act in concert to influence the heritable risk of an individual to develop (recurrent) vascular events. At present, genetic information cannot help clinicians to distinguish patients at high risk for recurrent vascular events.
Published: 2015

36. Common variation in PHACTR1 is associated with susceptibility to cervical artery dissection

Author: Debette, Stéphanie, Kamatani, Yoichiro, Wolf, Christiane, Agabiti Rosei, Enrico, Lanfranconi, Silvia, Ferrarese, Carlo, Susani, Emanuela, Bicocca, Milano, Giacalone, Giacomo, Paolucci, Stefano, Palmirotta, Raffaele, Paciaroni, Maurizio, Ballabio, Elena, Dittrich, Ralf, Parati, Eugenio A, Ciusani, Emilio, Fluri, Felix, Hatz, Florian, Gisler, Dominique, Amort, Margareth, Bevan, Steve, James, Tom, Olsson, Sandra, Holmegaard, Lukas, Touzé, Emmanuel, Altintas, Ayse, Martin, Juan José, Kittner, Steven, MItchell, Braxton, Stine, Colin, O'Connell, Jeff, Dueker, Nicole, Koudstaal, Peter J, de Lau, Lonneke M L, Hofman, Albert, Southerland, Andrew M, Verhaaren, Benjamin F, Uitterlinden, Andre G, Montaner, Joan, Mendioroz, Maite, Yadav, Sunaina, Khan, Muhammad Saleem, Wilder, Michael, van Dijk, Ewoud, Maaijwee, Noortje, Rutten-Jacobs, Loes, Samson, Yves, Kramer, Jamie, Malik, Shaneela, Brott, Thomas G, Brown, Robert D, Singleton, Andrew, Hardy, John, Rich, Stephen S, Tanislav, Christian, Jungehülsing, Jan, Abboud, Shérine, Béjot, Yannick, Caso, Valeria, Bersano, Anna, Gschwendtner, Andreas, Metso, Tiina M, Sessa, Maria, Cole, John, Lamy, Chantal, Medeiros, Elisabeth, Beretta, Simone, Bonati, Leo H, Grau, Armin J, Michel, Patrik, Majersik, Jennifer J, Sharma, Pankaj, Kloss, Manja, Kalashnikova, Ludmila, Nazarova, Maria, Dobrynina, Larisa, Bartels, Eva, Guillon, Benoit, van den Herik, Evita G, Fernandez-Cadenas, Israel, Jood, Katarina, Nalls, Michael A, De Leeuw, Frank-Erik, Chauhan, Ganesh, Jern, Christina, Cheng, Yu-Ching, Werner, Inge, Metso, Antti J, Lichy, Christoph, Lyrer, Philippe A, Brandt, Tobias, Boncoraglio, Giorgio B, Wichmann, Heinz-Erich, Gieger, Christian, Engelter, Stefan T, Johnson, Andrew D, Böttcher, Thomas, Castellano, Maurizio, Arveiler, Dominique, Ikram, M Arfan, Breteler, Monique M B, Padovani, Alessandro, Meschia, James F, Kuhlenbäumer, Gregor, Rolfs, Arndt, Pezzini, Alessandro, Worrall, Bradford B, Consortium, International Stroke Genetics, Ringelstein, Erich-Bernd, Zelenika, Diana, Tatlisumak, Turgut, Lathrop, Mark, Leys, Didier, Amouyel, Philippe, Dallongeville, Jean, Group, CADISP, Thijs, Vincent, Lemmens, Robin, Pandolfo, Massimo, Bodenant, Marie, Louillet, Fabien, Mas, Jean-Louis, Deltour, Sandrine, Leder, Sara, Léger, Anne, Canaple, Sandrine, Godefroy, Olivier, Markus, Hugh S, Giroud, Maurice, Jacquin, Agnès, Moulin, Thierry, Vullier, Fabrice, Tzourio, Christophe, Dos Santos, Michael, Malik, Rainer, Hausser, Ingrid, Thomas-Feles, Constanze, Weber, Ralf, Dichgans, Martin, Grond-Ginsbach, Caspar, Hacke, Werner, Giossi, Alessia, Volonghi, Irene, Costa, Paolo, del Zotto, Elisabetta, Morotti, Andrea, Poli, Loris, Lorenza Muiesan, Maria, Salvetti, Massimo, Epidémiologie des maladies chroniques: impact des intéractions gène environnement sur la santé des populations, Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Epidemiologie-Biostatistique [Bordeaux], Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bordeaux Ségalen [Bordeaux 2], Centre National de Génotypage (CNG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), RIKEN Center for Integrative Medical Sciences [Yokohama] (RIKEN IMS), RIKEN - Institute of Physical and Chemical Research [Japon] (RIKEN), Helsinki University Central Hospital [Finland] (HUCH), Heidelberg University Hospital [Heidelberg], University Hospital Basel [Basel], Università degli Studi di Brescia = University of Brescia (UniBs), University Hospitals Leuven [Leuven], Leuven Center for Cancer Biology (VIB-KU-CCB), Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven)-Vlaams Instituut voor Biotechnologie [Ghent, Belgique] (VIB), University of Cambridge [UK] (CAM), Institute for Stroke and Dementia Research (ISD), Klinikum der Universität [München]-Ludwig Maximilian University [Munich] (LMU), Ludwig-Maximilians-Universität München (LMU), University Hospital Münster - Universitaetsklinikum Muenster [Germany] (UKM), Centre Hospitalier Sainte Anne [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Neurologie [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), University of Virginia, CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Laboratoire de Neurochirurgie Expérimentale [Brussels] (ULB 257), Hôpital Erasme [Bruxelles] (ULB), Faculté de Médecine [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB)-Faculté de Médecine [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB), Service de Neurologie générale, vasculaire et dégénérative (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Università degli Studi di Perugia = University of Perugia (UNIPG), Fondazione IRCCS Istituto Neurologico 'Carlo Besta', Munich Cluster for systems neurology [Munich] (SyNergy), Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM)-Ludwig-Maximilians-Universität München (LMU), Ospedale San Raffaele, University of Maryland School of Medicine, University of Maryland System, Service de neurologie [Amiens], CHU Amiens-Picardie, Laboratoire de Neurosciences Fonctionnelles et Pathologies - UR UPJV 4559 (LNFP), Université de Picardie Jules Verne (UPJV), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Università degli Studi di Milano-Bicocca = University of Milano-Bicocca (UNIMIB), Klinikum Ludwigshafen [Germany], Service of Neurology [CHUV, Lausanne, Switzerland], Centre Hospitalier Universitaire Vaudois [Lausanne] (CHUV), University of Utah School of Medicine [Salt Lake City], Institute of Cardiovascular Research (ICR2UL), Royal Holloway [University of London] (RHUL), Ashford and St Peter's hospitals NHS foundation trust, Russian Academy of Sciences [Moscow] (RAS), Centre for Cognition and Decision Making [HSE, Moscow], Institut of Cognitive Neuroscience [HSE, Moscow] (ICN), Vysšaja škola èkonomiki = National Research University Higher School of Economics [Moscow] (HSE)-Vysšaja škola èkonomiki = National Research University Higher School of Economics [Moscow] (HSE), Zentrum für neurologische Gefäßdiagnostik - Center for Neurological Vascular Diagnostics [Munich, Germany], Service de neurologie [Nantes], Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Hôpital Guillaume-et-René-Laennec [Saint-Herblain], Department of Neurology [Erasmus MC, Rotterdam], Erasmus University Medical Center [Rotterdam] (Erasmus MC), Hospital Universitario Mutua de Terrassa, Vall d'Hebron University Hospital [Barcelona], Insitute of Neuroscience and Physiology, University of Gothenburg (GU), National Institute on Aging [Bethesda, USA] (NIA), National Institutes of Health [Bethesda] (NIH), Donders Institute for Brain, Cognition and Behaviour, Radboud University [Nijmegen], Schmieder Klinik [Heidelberg, Germany], Helmholtz Zentrum München = German Research Center for Environmental Health, Framingham Heart Study, Boston University [Boston] (BU)-National Heart, Lung, and Blood Institute [Bethesda] (NHLBI), University Hospital Rostock, Progression tumorale et microenvironnement. Approches translationnelles et épidémiologie, Université de Strasbourg (UNISTRA)-CHU Strasbourg-Les Hôpitaux Universitaires de Strasbourg (HUS)-Institut Régional du Cancer-Centre Paul Strauss : Centre Régional de Lutte contre le Cancer (CRLCC), Netherlands Consortium for Healthy Aging [Leiden, Netherlands] (NCHA), German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), University of Brescia, Mayo Clinic [Jacksonville], Institute of Experimental Medicine - Institut für Experimentelle Medizin [Kiel, Germany] (IEM), Christian-Albrechts-Universität zu Kiel (CAU), Westfälische Wilhelms-Universität Münster = University of Münster (WWU), Centre d'Etude du Polymorphisme Humain (CEPH), Université Paris Diderot - Paris 7 (UPD7)-Institut Universitaire d'Hématologie (IUH), Université Paris Diderot - Paris 7 (UPD7)-Fondation Jean Dausset, McGill University and Genome Quebec Innovation Centre, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Université de Lille, Pharmacologie de la mort neuronale et de la plasticité cérébrale, IFR114-Université de Lille, Droit et Santé, Réseau International des Instituts Pasteur (RIIP), Epidémiologie des maladies chroniques : impact des interactions gène environnement sur la santé des populations, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé, The CADISP study has been supported by INSERM, Lille 2 University, Institut Pasteur de Lille and Lille University Hospital and received funding from the European Regional Development Fund (FEDER funds) and Région Nord-Pas-de-Calais in the framework of Contrat de Projets Etat-Region 2007–2013 Région Nord-Pas-de-Calais (grant 09120030), Centre National de Génotypage, the Emil Aaltonen Foundation, the Paavo Ilmari Ahvenainen Foundation, the Helsinki University Central Hospital Research Fund, the Helsinki University Medical Foundation, the Päivikki and Sakari Sohlberg Foundation, the Aarne Koskelo Foundation, the Maire Taponen Foundation, the Aarne and Aili Turunen Foundation, the Lilly Foundation, the Alfred Kordelin Foundation, the Finnish Medical Foundation, the Orion Farmos Research Foundation, the Maud Kuistila Foundation, the Finnish Brain Foundation, the Biomedicum Helsinki Foundation, Projet Hospitalier de Recherche Clinique Régional, Fondation de France, Génopôle de Lille, Adrinord, the Basel Stroke Funds, the Käthe-Zingg-Schwichtenberg-Fonds of the Swiss Academy of Medical Sciences and the Swiss Heart Foundation.L.H.B., S.T.E. and P.A.L. were supported, in part, by a grant from the Swiss National Science Foundation (33CM30-124119). S.D. is supported by a Chair of Excellence from the French National Research Agency (ANR). S.D. and M.D. are supported by a grant from the Leducq Foundation. M.D. is supported by the Vascular Dementia Research Foundation. I.F.-C. is supported by the Miguel Servet programme (CP12/03298) from the Spanish Ministry of Health (Instituto de Salud Carlos III). G.K. is a member of the Deutsche Forschungsgemeinschaft Cluster of Excellence 'Inflammation at Interfaces'. P.S. is supported by a Department of Health (UK) senior fellowship. A.M.S. is supported by the American Heart Association/American Stroke Association National Clinical Research Program (AHA 3CRP14140001). V.T. is supported by Fonds Wetenschappelijk Onderzoek Flanders., CADISP Group, RIKEN Center for Integrative Medical Science, Università degli Studi di Brescia [Brescia], University of Virginia [Charlottesville], Service des Urgences Cérébro-Vasculaires [CHU Pitié-Salpêtrière]], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], Laboratoire de Neurologie Expérimentale [ULB, Brussels, Belgium] (ULB 257), Université Libre de Bruxelles [Bruxelles] (ULB)-Hôpital Erasme (Bruxelles), Università degli Studi di Perugia (UNIPG), Technische Universität München [München] (TUM)-Ludwig-Maximilians-Universität München (LMU), Centre Hospitalier Régional Universitaire [Besançon] (CHRU Besançon), Università degli Studi di Milano-Bicocca [Milano] (UNIMIB), National Research University Higher School of Economics [Moscow] (HSE)-National Research University Higher School of Economics [Moscow] (HSE), Radboud university [Nijmegen], Helmholtz-Zentrum München (HZM), Westfälische Wilhelms-Universität Münster (WWU), The authors thank the staff and participants of all CADISP centers for their important contributions., Service des Urgences Cérébro-Vasculaires [CHU Pitié-Salpétriêre], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Fondation Jean Dausset-Institut Universitaire d'Hématologie (IUH), Université Paris Diderot - Paris 7 (UPD7)-Université Paris Diderot - Paris 7 (UPD7), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Erasmus MC other, Epidemiology, Debette, S, Kamatani, Y, Metso, T, Kloss, M, Chauhan, G, Engelter, S, Pezzini, A, Thijs, V, Markus, H, Dichgans, M, Wolf, C, Dittrich, R, Touzé, E, Southerland, A, Samson, Y, Abboud, S, Béjot, Y, Caso, V, Bersano, A, Gschwendtner, A, Sessa, M, Cole, J, Lamy, C, Medeiros, E, Beretta, S, Bonati, L, Grau, A, Michel, P, Majersik, J, Sharma, P, Kalashnikova, L, Nazarova, M, Dobrynina, L, Bartels, E, Guillon, B, Van Den Herik, E, Fernandez Cadenas, I, Jood, K, Nalls, M, De Leeuw, F, Jern, C, Cheng, Y, Werner, I, Metso, A, Lichy, C, Lyrer, P, Brandt, T, Boncoraglio, G, Wichmann, H, Gieger, C, Johnson, A, Böttcher, T, Castellano, M, Arveiler, D, Ikram, M, Breteler, M, Padovani, A, Meschia, J, Kuhlenbäumer, G, Rolfs, A, Worrall, B, Ringelstein, E, Zelenika, D, Tatlisumak, T, Lathrop, M, Leys, D, Amouyel, P, Dallongeville, J, Lemmens R, P, and Ferrarese, C
Subjects: Male, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Myocardial Infarction, Genome-wide association study, Carotid Artery, Internal, Dissection, Gastroenterology, epidemiology [Carotid Artery, Internal, Dissection], Brain Ischemia, 0302 clinical medicine, Migraine Disorder, Odds Ratio, Finland, Vertebral Artery Dissection, 0303 health sciences, education.field_of_study, epidemiology [Hypercholesterolemia], MESH: Middle Aged, MESH: Polymorphism, Single Nucleotide, Phactr-1 protein, human, MESH: Brain Ischemia, MESH: Follow-Up Studies, 3. Good health, MESH: Myocardial Infarction, Human, medicine.medical_specialty, Migraine Disorders, Hypercholesterolemia, MESH: Vertebral Artery Dissection, Lower risk, genetics [Brain Ischemia], Article, Follow-Up Studie, MESH: Carotid Artery, Internal, Dissection, 03 medical and health sciences, Genetic, SDG 3 - Good Health and Well-being, genetics [Carotid Artery, Internal, Dissection], Genetics, Genetic predisposition, epidemiology [Brain Ischemia], Humans, epidemiology [Vertebral Artery Dissection], Polymorphism, education, Alleles, MESH: Humans, genetics [Vertebral Artery Dissection], MESH: Adult, Odds ratio, Microfilament Protein, medicine.disease, Adult, Female, Follow-Up Studies, Genetic Pleiotropy, Genetic Predisposition to Disease, Genome-Wide Association Study, Hypertension, Microfilament Proteins, Middle Aged, Obesity, Risk Factors, Polymorphism, Single Nucleotide, MESH: Genome-Wide Association Study, Carotid Artery, MESH: Female, 030217 neurology & neurosurgery, epidemiology [Finland], Cervical Artery, Vertebral artery dissection, epidemiology [Hypertension], MESH: Hypertension, MESH: Risk Factors, MESH: Obesity, Stroke, Allele, Dissection, MESH: Finland, MESH: Genetic Predisposition to Disease, MESH: Hypercholesterolemia, Single Nucleotide, MESH: Migraine Disorders, Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3], epidemiology [Myocardial Infarction], [INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV], [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, Population, MESH: Genetic Pleiotropy, physiology [Microfilament Proteins], Biology, MESH: Microfilament Proteins, Internal medicine, ddc:570, medicine, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, 030304 developmental biology, epidemiology [Obesity], Risk Factor, MESH: Alleles, [INFO.INFO-CV]Computer Science [cs]/Computer Vision and Pattern Recognition [cs.CV], Internal, MESH: Odds Ratio, MESH: Male, epidemiology [Migraine Disorders], genetics [Microfilament Proteins]
Abstract: Item does not contain fulltext Cervical artery dissection (CeAD), a mural hematoma in a carotid or vertebral artery, is a major cause of ischemic stroke in young adults although relatively uncommon in the general population (incidence of 2.6/100,000 per year). Minor cervical traumas, infection, migraine and hypertension are putative risk factors, and inverse associations with obesity and hypercholesterolemia are described. No confirmed genetic susceptibility factors have been identified using candidate gene approaches. We performed genome-wide association studies (GWAS) in 1,393 CeAD cases and 14,416 controls. The rs9349379[G] allele (PHACTR1) was associated with lower CeAD risk (odds ratio (OR) = 0.75, 95% confidence interval (CI) = 0.69-0.82; P = 4.46 x 10(-10)), with confirmation in independent follow-up samples (659 CeAD cases and 2,648 controls; P = 3.91 x 10(-3); combined P = 1.00 x 10(-11)). The rs9349379[G] allele was previously shown to be associated with lower risk of migraine and increased risk of myocardial infarction. Deciphering the mechanisms underlying this pleiotropy might provide important information on the biological underpinnings of these disabling conditions.
Published: 2015

37. Protection of Brain Injury by Amniotic Mesenchymal Stromal Cell-Secreted Metabolites

Author: Pischiutta, Francesca, Brunelli, Laura, Romele, Pietro, Silini, Antonietta, Sammali, Eliana, Paracchini, Lara, Marchini, Sergio, Talamini, Laura, Bigini, Paolo, Boncoraglio, Giorgio B, Pastorelli, Roberta, De Simoni, Maria Grazia, Parolini, Ornella, Zanier, Elisa R., Parolini, Ornella (ORCID:0000-0002-5211-6430), Pischiutta, Francesca, Brunelli, Laura, Romele, Pietro, Silini, Antonietta, Sammali, Eliana, Paracchini, Lara, Marchini, Sergio, Talamini, Laura, Bigini, Paolo, Boncoraglio, Giorgio B, Pastorelli, Roberta, De Simoni, Maria Grazia, Parolini, Ornella, Zanier, Elisa R., and Parolini, Ornella (ORCID:0000-0002-5211-6430)
Abstract: OBJECTIVES:To define the features of human amniotic mesenchymal stromal cell secretome and its protective properties in experimental models of acute brain injury. DESIGN:Prospective experimental study. SETTING:Laboratory research. SUBJECTS:C57Bl/6 mice. INTERVENTIONS:Mice subjected to sham or traumatic brain injury by controlled cortical impact received human amniotic mesenchymal stromal cells or phosphate-buffered saline infused intracerebroventricularly or intravenously 24 hours after injury. Organotypic cortical brain slices exposed to ischemic injury by oxygen-glucose deprivation were treated with human amniotic mesenchymal stromal cells or with their secretome (conditioned medium) in a transwell system. MEASUREMENTS AND MAIN RESULTS:Traumatic brain injured mice receiving human amniotic mesenchymal stromal cells intravenously or intracerebroventricularly showed early and lasting functional and anatomical brain protection. cortical slices injured by oxigen-glucose deprivation and treated with human amniotic mesenchymal stromal cells or conditioned medium showed comparable protective effects (neuronal rescue, promotion of M2 microglia polarization, induction of trophic factors) indicating that the exposure of human amniotic mesenchymal stromal cells to the injured tissue is not necessary for the release of bioactive factors. Using sequential size-exclusion and gel-filtration chromatography, we identified a conditioned medium subfraction, which specifically displays these highly protective properties and we found that this fraction was rich in bioactive molecules with molecular weight smaller than 700 Da. Quantitative RNA analysis and mass spectrometry-based peptidomics showed that the active factors are not proteins or RNAs. The metabolomic profiling of six metabolic classes identified a list of molecules whose abundance was selectively elevated in the active conditioned medium fraction. CONCLUSIONS:Human amniotic mesenchymal stromal cell-secreted factors protect
Published: 2016

38. A novel MMP12 locus Is associated with large artery atherosclerotic stroke Using a genome-wide age-at-onset informed approach

Author: Traylor, Matthew, Mäkelä, Kari-Matti, Kilarski, Laura L, Holliday, Elizabeth G, Devan, William J, Nalls, Mike A, Wiggins, Kerri L, Zhao, Wei, Cheng, Yu-Ching, Achterberg, Sefanja, Malik, Rainer, Sudlow, Cathie, Bevan, Steve, Raitoharju, Emma, METASTROKE, International Stroke Genetics Consortium, Wellcome Trust Case Consortium 2 (WTCCC2), Oksala, Niku, Thijs, Vincent, Lemmens, Robin, Lindgren, Arne, Slowik, Agnieszka, Maguire, Jane M, Walters, Matthew, Algra, Ale, Sharma, Pankaj, Attia, John R, Boncoraglio, Giorgio B, Rothwell, Peter M, De Bakker, Paul IW, Bis, Joshua C, Saleheen, Danish, Kittner, Steven J, Mitchell, Braxton D, Rosand, Jonathan, Meschia, James F, Levi, Christopher, Dichgans, Martin, Lehtimäki, Terho, Lewis, Cathryn M, Markus, Hugh S, Traylor, Matthew [0000-0001-6624-8621], Markus, Hugh [0000-0002-9794-5996], and Apollo - University of Cambridge Repository
Subjects: Adult, Male, lcsh:QH426-470, Myocardial Infarction, Arteries, Coronary Artery Disease, Middle Aged, Polymorphism, Single Nucleotide, lcsh:Genetics, C431 Medical Genetics, Matrix Metalloproteinase 12, Humans, Female, Age of Onset, Aged, Genome-Wide Association Study, Glycosaminoglycans
Abstract: Genome-wide association studies (GWAS) have begun to identify the common genetic component to ischaemic stroke (IS). However, IS has considerable phenotypic heterogeneity. Where clinical covariates explain a large fraction of disease risk, covariate informed designs can increase power to detect associations. As prevalence rates in IS are markedly affected by age, and younger onset cases may have higher genetic predisposition, we investigated whether an age-at-onset informed approach could detect novel associations with IS and its subtypes; cardioembolic (CE), large artery atherosclerosis (LAA) and small vessel disease (SVD) in 6,778 cases of European ancestry and 12,095 ancestry-matched controls. Regression analysis to identify SNP associations was performed on posterior liabilities after conditioning on age-at-onset and affection status. We sought further evidence of an association with LAA in 1,881 cases and 50,817 controls, and examined mRNA expression levels of the nearby genes in atherosclerotic carotid artery plaques. Secondly, we performed permutation analyses to evaluate the extent to which age-at-onset informed analysis improves significance for novel loci. We identified a novel association with an MMP12 locus in LAA (rs660599; p = 2.5×10⁻⁷), with independent replication in a second population (p = 0.0048, OR(95% CI) = 1.18(1.05-1.32); meta-analysis p = 2.6×10⁻⁸). The nearby gene, MMP12, was significantly overexpressed in carotid plaques compared to atherosclerosis-free control arteries (p = 1.2×10⁻¹⁵; fold change = 335.6). Permutation analyses demonstrated improved significance for associations when accounting for age-at-onset in all four stroke phenotypes (p
Published: 2014

39. Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies

Author: Chauhan, Ganesh, primary, Arnold, Corey R, additional, Chu, Audrey Y, additional, Fornage, Myriam, additional, Reyahi, Azadeh, additional, Bis, Joshua C, additional, Havulinna, Aki S, additional, Sargurupremraj, Muralidharan, additional, Smith, Albert Vernon, additional, Adams, Hieab H H, additional, Choi, Seung Hoan, additional, Pulit, Sara L, additional, Trompet, Stella, additional, Garcia, Melissa E, additional, Manichaikul, Ani, additional, Teumer, Alexander, additional, Gustafsson, Stefan, additional, Bartz, Traci M, additional, Bellenguez, Céline, additional, Vidal, Jean Sebastien, additional, Jian, Xueqiu, additional, Kjartansson, Olafur, additional, Wiggins, Kerri L, additional, Satizabal, Claudia L, additional, Xue, Flora, additional, Ripatti, Samuli, additional, Liu, Yongmei, additional, Deelen, Joris, additional, den Hoed, Marcel, additional, Bevan, Steve, additional, Hopewell, Jemma C, additional, Malik, Rainer, additional, Heckbert, Susan R, additional, Rice, Kenneth, additional, Smith, Nicholas L, additional, Levi, Christopher, additional, Sharma, Pankaj, additional, Sudlow, Cathie LM, additional, Nik, Ali Moussavi, additional, Cole, John W, additional, Schmidt, Reinhold, additional, Meschia, James, additional, Thijs, Vincent, additional, Lindgren, Arne, additional, Melander, Olle, additional, Grewal, Raji P, additional, Sacco, Ralph L, additional, Rundek, Tatjana, additional, Rothwell, Peter M, additional, Arnett, Donna K, additional, Jern, Christina, additional, Johnson, Julie A, additional, Benavente, Oscar R, additional, Wassertheil-Smoller, Sylvia, additional, Lee, Jin-Moo, additional, Wong, Quenna, additional, Aparicio, Hugo J, additional, Engelter, Stefan T, additional, Kloss, Manja, additional, Leys, Didier, additional, Pezzini, Alessandro, additional, Buring, Julie E, additional, Ridker, Paul M, additional, Berr, Claudine, additional, Dartigues, Jean-François, additional, Hamsten, Anders, additional, Magnusson, Patrik K, additional, Traylor, Matthew, additional, Pedersen, Nancy L, additional, Lannfelt, Lars, additional, Lindgren, Lars, additional, Lindgren, Cecilia M, additional, Morris, Andrew P, additional, Jimenez-Conde, Jordi, additional, Montaner, Joan, additional, Radmanesh, Farid, additional, Slowik, Agnieszka, additional, Woo, Daniel, additional, Hofman, Albert, additional, Koudstaal, Peter J, additional, Portegies, Marileen L P, additional, Uitterlinden, André G, additional, de Craen, Anton J M, additional, Ford, Ian, additional, Jukema, J Wouter, additional, Stott, David J, additional, Allen, Norrina B, additional, Sale, Michele M, additional, Johnson, Andrew D, additional, Bennett, David A, additional, De Jager, Philip L, additional, White, Charles C, additional, Grabe, Hans Jörgen, additional, Markus, Marcello Ricardo Paulista, additional, Schminke, Ulf, additional, Boncoraglio, Giorgio B, additional, Clarke, Robert, additional, Kamatani, Yoichiro, additional, Dallongeville, Jean, additional, Lopez, Oscar L, additional, Rotter, Jerome I, additional, Nalls, Michael A, additional, Gottesman, Rebecca F, additional, Griswold, Michael E, additional, Knopman, David S, additional, Windham, B Gwen, additional, Beiser, Alexa, additional, Markus, Hugh S, additional, Vartiainen, Erkki, additional, French, Curtis R, additional, Dichgans, Martin, additional, Pastinen, Tomi, additional, Lathrop, Mark, additional, Gudnason, Vilmundur, additional, Kurth, Tobias, additional, Psaty, Bruce M, additional, Harris, Tamara B, additional, Rich, Stephen S, additional, deStefano, Anita L, additional, Schmidt, Carsten Oliver, additional, Worrall, Bradford B, additional, Rosand, Jonathan, additional, Salomaa, Veikko, additional, Mosley, Thomas H, additional, Ingelsson, Erik, additional, van Duijn, Cornelia M, additional, Tzourio, Christophe, additional, Rexrode, Kathryn M, additional, Lehmann, Ordan J, additional, Launer, Lenore J, additional, Ikram, M Arfan, additional, Carlsson, Peter, additional, Chasman, Daniel I, additional, Childs, Sarah J, additional, Longstreth, William T, additional, Seshadri, Sudha, additional, and Debette, Stéphanie, additional
Published: 2016
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40. Causal Assessment of Serum Urate Levels in Cardiometabolic Diseases Through a Mendelian Randomization Study

Author: Keenan, Tanya, primary, Zhao, Wei, additional, Rasheed, Asif, additional, Ho, Weang K., additional, Malik, Rainer, additional, Felix, Janine F., additional, Young, Robin, additional, Shah, Nabi, additional, Samuel, Maria, additional, Sheikh, Nasir, additional, Mucksavage, Megan L., additional, Shah, Omar, additional, Li, Jin, additional, Morley, Michael, additional, Laser, Annika, additional, Mallick, Nadeem Hayat, additional, Zaman, Khan Shah, additional, Ishaq, Mohammad, additional, Rasheed, Syed Zahed, additional, Memon, Fazal-ur-Rehman, additional, Ahmed, Faisal, additional, Hanif, Bashir, additional, Lakhani, Muhammad Shakir, additional, Fahim, Muhammad, additional, Ishaq, Madiha, additional, Shardha, Naresh Kumar, additional, Ahmed, Naveeduddin, additional, Mahmood, Khalid, additional, Iqbal, Waseem, additional, Akhtar, Saba, additional, Raheel, Rabia, additional, O'Donnell, Christopher J., additional, Hengstenberg, Christian, additional, März, Winifred, additional, Kathiresan, Sekar, additional, Samani, Nilesh, additional, Goel, Anuj, additional, Hopewell, Jemma C., additional, Chambers, John, additional, Cheng, Yu-Ching, additional, Sharma, Pankaj, additional, Yang, Qiong, additional, Rosand, Jonathan, additional, Boncoraglio, Giorgio B., additional, Kazmi, Shahana Urooj, additional, Hakonarson, Hakon, additional, Köttgen, Anna, additional, Kalogeropoulos, Andreas, additional, Frossard, Philippe, additional, Kamal, Ayeesha, additional, Dichgans, Martin, additional, Cappola, Thomas, additional, Reilly, Muredach P., additional, Danesh, John, additional, Rader, Daniel J., additional, Voight, Benjamin F., additional, and Saleheen, Danish, additional
Published: 2016
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41. Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study

Author: Pulit, Sara L, primary, McArdle, Patrick F, additional, Wong, Quenna, additional, Malik, Rainer, additional, Gwinn, Katrina, additional, Achterberg, Sefanja, additional, Algra, Ale, additional, Amouyel, Philippe, additional, Anderson, Christopher D, additional, Arnett, Donna K, additional, Arsava, Ethem Murat, additional, Attia, John, additional, Ay, Hakan, additional, Bartz, Traci M, additional, Battey, Thomas, additional, Benavente, Oscar R, additional, Bevan, Steve, additional, Biffi, Alessandro, additional, Bis, Joshua C, additional, Blanton, Susan H, additional, Boncoraglio, Giorgio B, additional, Brown, Robert D, additional, Burgess, Annette I, additional, Carrera, Caty, additional, Chapman Smith, Sherita N, additional, Chasman, Daniel I, additional, Chauhan, Ganesh, additional, Chen, Wei-Min, additional, Cheng, Yu-Ching, additional, Chong, Michael, additional, Cloonan, Lisa K, additional, Cole, John W, additional, Cotlarciuc, Ioana, additional, Cruchaga, Carlos, additional, Cuadrado-Godia, Elisa, additional, Dave, Tushar, additional, Dawson, Jesse, additional, Debette, Stéphanie, additional, Delavaran, Hossein, additional, Dell, Cameron A, additional, Dichgans, Martin, additional, Doheny, Kimberly F, additional, Dong, Chuanhui, additional, Duggan, David J, additional, Engström, Gunnar, additional, Evans, Michele K, additional, Pallejà, Xavier Estivill, additional, Faul, Jessica D, additional, Fernández-Cadenas, Israel, additional, Fornage, Myriam, additional, Frossard, Philippe M, additional, Furie, Karen, additional, Gamble, Dale M, additional, Gieger, Christian, additional, Giese, Anne-Katrin, additional, Giralt-Steinhauer, Eva, additional, González, Hector M, additional, Goris, An, additional, Gretarsdottir, Solveig, additional, Grewal, Raji P, additional, Grittner, Ulrike, additional, Gustafsson, Stefan, additional, Han, Buhm, additional, Hankey, Graeme J, additional, Heitsch, Laura, additional, Higgins, Peter, additional, Hochberg, Marc C, additional, Holliday, Elizabeth, additional, Hopewell, Jemma C, additional, Horenstein, Richard B, additional, Howard, George, additional, Ikram, M Arfan, additional, Ilinca, Andreea, additional, Ingelsson, Erik, additional, Irvin, Marguerite R, additional, Jackson, Rebecca D, additional, Jern, Christina, additional, Conde, Jordi Jiménez, additional, Johnson, Julie A, additional, Jood, Katarina, additional, Kahn, Muhammad S, additional, Kaplan, Robert, additional, Kappelle, L Jaap, additional, Kardia, Sharon L R, additional, Keene, Keith L, additional, Kissela, Brett M, additional, Kleindorfer, Dawn O, additional, Koblar, Simon, additional, Labovitz, Daniel, additional, Launer, Lenore J, additional, Laurie, Cathy C, additional, Laurie, Cecelia A, additional, Lee, Cue Hyunkyu, additional, Lee, Jin-Moo, additional, Lehm, Manuel, additional, Lemmens, Robin, additional, Levi, Christopher, additional, Leys, Didier, additional, Lindgren, Arne, additional, Longstreth, W T, additional, Maguire, Jane, additional, Manichaikul, Ani, additional, Markus, Hugh S, additional, McClure, Leslie A, additional, McDonough, Caitrin W, additional, Meisinger, Christa, additional, Melander, Olle, additional, Meschia, James F, additional, Mola-Caminal, Marina, additional, Montaner, Joan, additional, Mosley, Thomas H, additional, Müller-Nurasyid, Martina, additional, Nalls, Mike A, additional, O'Connell, Jeffrey R, additional, O'Donnell, Martin, additional, Ois, ángel, additional, Papanicolaou, George J, additional, Paré, Guillaume, additional, Peddareddygari, Leema Reddy, additional, Pedersén, Annie, additional, Pera, Joanna, additional, Peters, Annette, additional, Poole, Deborah, additional, Psaty, Bruce M, additional, Rabionet, Raquel, additional, Raffeld, Miriam R, additional, Rannikmäe, Kristiina, additional, Rasheed, Asif, additional, Redfors, Petra, additional, Reiner, Alex P, additional, Rexrode, Kathryn, additional, Ribasés, Marta, additional, Rich, Stephen S, additional, Robberecht, Wim, additional, Rodriguez-Campello, Ana, additional, Rolfs, Arndt, additional, Roquer, Jaume, additional, Rose, Lynda M, additional, Rosenbaum, Daniel, additional, Rost, Natalia S, additional, Rothwell, Peter M, additional, Rundek, Tatjana, additional, Ryan, Kathleen A, additional, Sacco, Ralph L, additional, Sale, Michèle M, additional, Saleheen, Danish, additional, Salomaa, Veikko, additional, Sánchez-Mora, Cristina, additional, Schmidt, Carsten Oliver, additional, Schmidt, Helena, additional, Schmidt, Reinhold, additional, Schürks, Markus, additional, Scott, Rodney, additional, Segal, Helen C, additional, Seiler, Stephan, additional, Seshadri, Sudha, additional, Sharma, Pankaj, additional, Shuldiner, Alan R, additional, Silver, Brian, additional, Slowik, Agnieszka, additional, Smith, Jennifer A, additional, Söderholm, Martin, additional, Soriano, Carolina, additional, Sparks, Mary J, additional, Stanne, Tara, additional, Stefansson, Kari, additional, Stine, O Colin, additional, Strauch, Konstantin, additional, Sturm, Jonathan, additional, Sudlow, Cathie LM, additional, Tajuddin, Salman M, additional, Talbert, Robert L, additional, Tatlisumak, Turgut, additional, Thijs, Vincent, additional, Thorleifsson, Gudmar, additional, Thorsteindottir, Unnur, additional, Tiedt, Steffen, additional, Traylor, Matthew, additional, Trompet, Stella, additional, Valant, Valerie, additional, Waldenberger, Melanie, additional, Walters, Matthew, additional, Wang, Liyong, additional, Wassertheil-Smoller, Sylvia, additional, Weir, David R, additional, Wiggins, Kerri L, additional, Williams, Stephen R, additional, Wloch-Kopec, Dorota, additional, Woo, Daniel, additional, Woodfield, Rebecca, additional, Wu, Ona, additional, Xu, Huichun, additional, Zonderman, Alan B, additional, Worrall, Bradford B, additional, de Bakker, Paul IW, additional, Kittner, Steven J, additional, Mitchell, Braxton D, additional, Rosand, Jonathan, additional, Pulit, Sara L, additional, Sudlow, Cathie L M, additional, Worrall, Bradford B Worrall, additional, Arnett, Donna K Arnett, additional, Benavente, Oscar, additional, and Wasssertheil-Smoller, Sylvia, additional
Published: 2016
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42. No additional prognostic value of genetic information in the prediction of vascular events after cerebral ischemia of arterial origin: The PROMISe study

Author: Opleiding Neurologie, ZL Cerebrovasculaire Ziekten Medisch, Brain, CMM Groep Kaaij, JC onderzoeksprogramma Methodologie, Circulatory Health, Cancer, Epi Methoden Team 1, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 7, Cardiovasculaire Epi Team 9, HAG Diabetes, Interne Geneeskunde Vasculaire, Zorgeenheid Vaatchirurgie Medisch, Cardiologie, Achterberg, Sefanja, Kappelle, L. Jaap, De Bakker, Paul I W, Traylor, Matthew, Algra, Ale, Van Der Graaf, Y., Grobbee, D. E., Rutten, G. E H M, Visseren, F. L J, Moll, F. L., Mali, W. P T M, Doevendans, P. A., Martin, Farrall, Holliday, Elizabeth G., Sudlow, Cathie, Hopewell, Jemma C., Cheng, Yu Ching, Fornage, Myriam, Ikram, M. Arfan, Malik, Rainer, Bevan, Steve, Thorsteinsdottir, Unnur, DeStefano, Anita L., Worrall, Bradford B., Reiner, Alex P., Mitchell, Braxton D., Clarke, Robert, Levi, Christopher, Seshadri, Sudha, Boncoraglio, Giorgio B., Sharma, Pankaj, Bis, Joshua C., Gretarsdottir, Solveig, Psaty, Bruce M., Rothwell, Peter M., Rosand, Jonathan, Meschia, James F., Stefansson, Kari, Dichgans, Martin, Markus, Hugh S., Opleiding Neurologie, ZL Cerebrovasculaire Ziekten Medisch, Brain, CMM Groep Kaaij, JC onderzoeksprogramma Methodologie, Circulatory Health, Cancer, Epi Methoden Team 1, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 7, Cardiovasculaire Epi Team 9, HAG Diabetes, Interne Geneeskunde Vasculaire, Zorgeenheid Vaatchirurgie Medisch, Cardiologie, Achterberg, Sefanja, Kappelle, L. Jaap, De Bakker, Paul I W, Traylor, Matthew, Algra, Ale, Van Der Graaf, Y., Grobbee, D. E., Rutten, G. E H M, Visseren, F. L J, Moll, F. L., Mali, W. P T M, Doevendans, P. A., Martin, Farrall, Holliday, Elizabeth G., Sudlow, Cathie, Hopewell, Jemma C., Cheng, Yu Ching, Fornage, Myriam, Ikram, M. Arfan, Malik, Rainer, Bevan, Steve, Thorsteinsdottir, Unnur, DeStefano, Anita L., Worrall, Bradford B., Reiner, Alex P., Mitchell, Braxton D., Clarke, Robert, Levi, Christopher, Seshadri, Sudha, Boncoraglio, Giorgio B., Sharma, Pankaj, Bis, Joshua C., Gretarsdottir, Solveig, Psaty, Bruce M., Rothwell, Peter M., Rosand, Jonathan, Meschia, James F., Stefansson, Kari, Dichgans, Martin, and Markus, Hugh S.
Published: 2015

43. Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with stroke

Author: Traylor, Matthew, primary, Zhang, Cathy R., additional, Adib-Samii, Poneh, additional, Devan, William J., additional, Parsons, Owen E., additional, Lanfranconi, Silvia, additional, Gregory, Sarah, additional, Cloonan, Lisa, additional, Falcone, Guido J., additional, Radmanesh, Farid, additional, Fitzpatrick, Kaitlin, additional, Kanakis, Allison, additional, Barrick, Thomas R., additional, Moynihan, Barry, additional, Lewis, Cathryn M., additional, Boncoraglio, Giorgio B., additional, Lemmens, Robin, additional, Thijs, Vincent, additional, Sudlow, Cathie, additional, Wardlaw, Joanna, additional, Rothwell, Peter M., additional, Meschia, James F., additional, Worrall, Bradford B., additional, Levi, Christopher, additional, Bevan, Steve, additional, Furie, Karen L., additional, Dichgans, Martin, additional, Rosand, Jonathan, additional, Markus, Hugh S., additional, and Rost, Natalia, additional
Published: 2015
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44. Characterization of the biological processes shaping the genetic structure of the Italian population

Author: Parolo, Silvia, primary, Lisa, Antonella, additional, Gentilini, Davide, additional, Di Blasio, Anna Maria, additional, Barlera, Simona, additional, Nicolis, Enrico B., additional, Boncoraglio, Giorgio B., additional, Parati, Eugenio A., additional, and Bione, Silvia, additional
Published: 2015
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45. Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke

Author: International Stroke Genetics Consortium (ISGC), Wellcome Trust Case Control Consortium 2 (WTCCC2), Bellenguez, Céline, Bevan, Steve, Gschwendtner, Andreas, Spencer, Chris CA, Burgess, Annette I, Pirinen, Matti, Jackson, Caroline A, Traylor, Matthew, Strange, Amy, Su, Zhan, Band, Gavin, Syme, Paul D, Malik, Rainer, Pera, Joanna, Norrving, Bo, Lemmens, Robin, Freeman, Colin, Schanz, Renata, James, Tom, Poole, Deborah, Murphy, Lee, Segal, Helen, Cortellini, Lynelle, Cheng, Yu-Ching, Woo, Daniel, Nalls, Michael A, Müller-Myhsok, Bertram, Meisinger, Christa, Seedorf, Udo, Ross-Adams, Helen, Boonen, Steven, Wloch-Kopec, Dorota, Valant, Valerie, Slark, Julia, Furie, Karen, Delavaran, Hossein, Langford, Cordelia, Deloukas, Panos, Edkins, Sarah, Hunt, Sarah, Gray, Emma, Dronov, Serge, Peltonen, Leena, Gretarsdottir, Solveig, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Stefansson, Kari, Boncoraglio, Giorgio B, Parati, Eugenio A, Attia, John, Holliday, Elizabeth, Levi, Chris, Franzosi, Maria-Grazia, Goel, Anuj, Helgadottir, Anna, Blackwell, Jenefer M, Bramon, Elvira, Brown, Matthew A, Casas, Juan P, Corvin, Aiden, Duncanson, Audrey, Jankowski, Janusz, Mathew, Christopher G, Palmer, Colin NA, Plomin, Robert, Rautanen, Anna, Sawcer, Stephen J, Trembath, Richard C, Viswanathan, Ananth C, Wood, Nicholas W, Worrall, Bradford B, Kittner, Steven J, Mitchell, Braxton D, Kissela, Brett, Meschia, James F, Thijs, Vincent, Lindgren, Arne, Macleod, Mary Joan, Slowik, Agnieszka, Walters, Matthew, Rosand, Jonathan, Sharma, Pankaj, Farrall, Martin, Sudlow, Cathie LM, Rothwell, Peter M, Dichgans, Martin, Donnelly, Peter, and Markus, Hugh S
Abstract: Genetic factors have been implicated in stroke risk, but few replicated associations have been reported. We conducted a genome-wide association study (GWAS) for ischemic stroke and its subtypes in 3,548 affected individuals and 5,972 controls, all of European ancestry. Replication of potential signals was performed in 5,859 affected individuals and 6,281 controls. We replicated previous associations for cardioembolic stroke near PITX2 and ZFHX3 and for large vessel stroke at a 9p21 locus. We identified a new association for large vessel stroke within HDAC9 (encoding histone deacetylase 9) on chromosome 7p21.1 (including further replication in an additional 735 affected individuals and 28,583 controls) (rs11984041; combined P = 1.87 × 10(-11); odds ratio (OR) = 1.42, 95% confidence interval (CI) = 1.28-1.57). All four loci exhibited evidence for heterogeneity of effect across the stroke subtypes, with some and possibly all affecting risk for only one subtype. This suggests distinct genetic architectures for different stroke subtypes.
Published: 2012

46. Is Period3 Genotype Associated With Sleep and Recovery in Patients With Disorders of Consciousness?

Author: Bedini, Gloria, primary, Bersano, Anna, additional, Sebastiano, Davide Rossi, additional, Sattin, Davide, additional, Ciaraffa, Francesca, additional, Tosetti, Valentina, additional, Brenna, Greta, additional, Franceschetti, Silvana, additional, Ciusani, Emilio, additional, Leonardi, Matilde, additional, Vela-Gomez, Jesus, additional, Boncoraglio, Giorgio B., additional, and Parati, Eugenio A., additional
Published: 2015
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47. Prodromal Alzheimer's Disease Presenting as Cerebral Amyloid Angiopathy-Related Inflammation with Spontaneous Amyloid-Related Imaging Abnormalities and High Cerebrospinal Fluid Anti-Aβ Autoantibodies

Author: Boncoraglio, Giorgio B., primary, Piazza, Fabrizio, additional, Savoiardo, Mario, additional, Farina, Laura, additional, DiFrancesco, Jacopo C., additional, Prioni, Sara, additional, Tagliavini, Fabrizio, additional, Parati, Eugenio A., additional, and Giaccone, Giorgio, additional
Published: 2015
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48. Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12

Author: Kilarski, Laura L., Achterberg, Sefanja, Devan, William J., Traylor, Matthew, Malik, Rainer, Lindgren, Arne, Pare, Guillame, Sharma, Pankaj, Slowik, Agniesczka, Thijs, Vincent, Walters, Matthew, Worrall, Bradford B., Sale, Michele M., Algra, Ale, Kappelle, L. Jaap, Wijmenga, Cisca, Norrving, Bo, Sandling, Johanna K., Rönnblom, Lars, Goris, An, Franke, Andre, Sudlow, Cathie, Rothwell, Peter M., Levi, Christopher, Holliday, Elizabeth G., Fornage, Myriam, Psaty, Bruce, Gretarsdottir, Solveig, Thorsteinsdottir, Unnar, Seshadri, Sudha, Mitchell, Braxton D., Kittner, Steven, Clarke, Robert, Hopewell, Jemma C., Bis, Joshua C., Boncoraglio, Giorgio B., Meschia, James, Ikram, M. Arfan, Hansen, Bjorn M., Montaner, Joan, Thorleifsson, Gudmar, Stefanson, Kari, Rosand, Jonathan, de Bakker, Paul I. W., Farrall, Martin, Dichgans, Martin, Markus, Hugh S., Bevan, Steve, Kilarski, Laura L., Achterberg, Sefanja, Devan, William J., Traylor, Matthew, Malik, Rainer, Lindgren, Arne, Pare, Guillame, Sharma, Pankaj, Slowik, Agniesczka, Thijs, Vincent, Walters, Matthew, Worrall, Bradford B., Sale, Michele M., Algra, Ale, Kappelle, L. Jaap, Wijmenga, Cisca, Norrving, Bo, Sandling, Johanna K., Rönnblom, Lars, Goris, An, Franke, Andre, Sudlow, Cathie, Rothwell, Peter M., Levi, Christopher, Holliday, Elizabeth G., Fornage, Myriam, Psaty, Bruce, Gretarsdottir, Solveig, Thorsteinsdottir, Unnar, Seshadri, Sudha, Mitchell, Braxton D., Kittner, Steven, Clarke, Robert, Hopewell, Jemma C., Bis, Joshua C., Boncoraglio, Giorgio B., Meschia, James, Ikram, M. Arfan, Hansen, Bjorn M., Montaner, Joan, Thorleifsson, Gudmar, Stefanson, Kari, Rosand, Jonathan, de Bakker, Paul I. W., Farrall, Martin, Dichgans, Martin, Markus, Hugh S., and Bevan, Steve
Abstract: Objectives: To perform a genome-wide association study (GWAS) using the Immunochip array in 3,420 cases of ischemic stroke and 6,821 controls, followed by a meta-analysis with data from more than 14,000 additional ischemic stroke cases. Methods: Using the Immunochip, we genotyped 3,420 ischemic stroke cases and 6,821 controls. After imputation we meta-analyzed the results with imputed GWAS data from 3,548 cases and 5,972 controls recruited from the ischemic stroke WTCCC2 study, and with summary statistics from a further 8,480 cases and 56,032 controls in the METASTROKE consortium. A final in silico "look-up" of 2 single nucleotide polymorphisms in 2,522 cases and 1,899 controls was performed. Associations were also examined in 1,088 cases with intracerebral hemorrhage and 1,102 controls. Results: In an overall analysis of 17,970 cases of ischemic stroke and 70,764 controls, we identified a novel association on chromosome 12q24 (rs10744777, odds ratio [OR] 1.10 [1.07-1.13], p = 7.12 x 10(-11)) with ischemic stroke. The association was with all ischemic stroke rather than an individual stroke subtype, with similar effect sizes seen in different stroke subtypes. There was no association with intracerebral hemorrhage (OR 1.03 [0.90-1.17], p = 0.695). Conclusion: Our results show, for the first time, a genetic risk locus associated with ischemic stroke as a whole, rather than in a subtype-specific manner. This finding was not associated with intracerebral hemorrhage.
Published: 2014
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49. Ischemic stroke is associated with the ABO locus : the EuroCLOT study

Author: Williams, Frances M. K., Carter, Angela M., Hysi, Pirro G., Surdulescu, Gabriela, Hodgkiss, Dylan, Soranzo, Nicole, Traylor, Matthew, Bevan, Steve, Dichgans, Martin, Rothwell, Peter M. W., Sudlow, Cathie, Farrall, Martin, Silander, Kaisa, Kaunisto, Mari, Wagner, Peter, Saarela, Olli, Kuulasmaa, Kari, Virtamo, Jarmo, Salomaa, Veikko, Amouyel, Philippe, Arveiler, Dominique, Ferrieres, Jean, Wiklund, Per-Gunnar, Ikram, M. Arfan, Hofman, Albert, Boncoraglio, Giorgio B., Parati, Eugenio A., Helgadottir, Anna, Gretarsdottir, Solveig, Thorsteinsdottir, Unnur, Thorleifsson, Gudmar, Stefansson, Kari, Seshadri, Sudha, DeStefano, Anita, Gschwendtner, Andreas, Psaty, Bruce, Longstreth, Will, Mitchell, Braxton D., Cheng, Yu-Ching, Clarke, Robert, Ferrario, Marco, Bis, Joshua C., Levi, Christopher, Attia, John, Holliday, Elizabeth G., Scott, Rodney J., Fornage, Myriam, Sharma, Pankaj, Furie, Karen L., Rosand, Jonathan, Nalls, Mike, Meschia, James, Mosely, Thomas H., Evans, Alun, Palotie, Aarno, Markus, Hugh S., Grant, Peter J., Spector, Tim D., Williams, Frances M. K., Carter, Angela M., Hysi, Pirro G., Surdulescu, Gabriela, Hodgkiss, Dylan, Soranzo, Nicole, Traylor, Matthew, Bevan, Steve, Dichgans, Martin, Rothwell, Peter M. W., Sudlow, Cathie, Farrall, Martin, Silander, Kaisa, Kaunisto, Mari, Wagner, Peter, Saarela, Olli, Kuulasmaa, Kari, Virtamo, Jarmo, Salomaa, Veikko, Amouyel, Philippe, Arveiler, Dominique, Ferrieres, Jean, Wiklund, Per-Gunnar, Ikram, M. Arfan, Hofman, Albert, Boncoraglio, Giorgio B., Parati, Eugenio A., Helgadottir, Anna, Gretarsdottir, Solveig, Thorsteinsdottir, Unnur, Thorleifsson, Gudmar, Stefansson, Kari, Seshadri, Sudha, DeStefano, Anita, Gschwendtner, Andreas, Psaty, Bruce, Longstreth, Will, Mitchell, Braxton D., Cheng, Yu-Ching, Clarke, Robert, Ferrario, Marco, Bis, Joshua C., Levi, Christopher, Attia, John, Holliday, Elizabeth G., Scott, Rodney J., Fornage, Myriam, Sharma, Pankaj, Furie, Karen L., Rosand, Jonathan, Nalls, Mike, Meschia, James, Mosely, Thomas H., Evans, Alun, Palotie, Aarno, Markus, Hugh S., Grant, Peter J., and Spector, Tim D.
Abstract: Objective: End-stage coagulation and the structure/function of fibrin are implicated in the pathogenesis of ischemic stroke. We explored whether genetic variants associated with end-stage coagulation in healthy volunteers account for the genetic predisposition to ischemic stroke and examined their influence on stroke subtype. Methods: Common genetic variants identified through genome-wide association studies of coagulation factors and fibrin structure/function in healthy twins (n = 2,100, Stage 1) were examined in ischemic stroke (n = 4,200 cases) using 2 independent samples of European ancestry (Stage 2). A third clinical collection having stroke subtyping (total 8,900 cases, 55,000 controls) was used for replication (Stage 3). Results: Stage 1 identified 524 single nucleotide polymorphisms (SNPs) from 23 linkage disequilibrium blocks having significant association (p < 5 x 10(-8)) with 1 or more coagulation/fibrin phenotypes. The most striking associations included SNP rs5985 with factor XIII activity (p = 2.6 x 10(-186)), rs10665 with FVII (p = 2.4 x 10(-47)), and rs505922 in the ABO gene with both von Willebrand factor (p = 4.7 x 10(-57)) and factor VIII (p = 1.2 x 10(-36)). In Stage 2, the 23 independent SNPs were examined in stroke cases/noncases using MOnica Risk, Genetics, Archiving and Monograph (MORGAM) and Wellcome Trust Case Control Consortium 2 collections. SNP rs505922 was nominally associated with ischemic stroke (odds ratio = 0.94, 95% confidence interval = 0.88-0.99, p = 0.023). Independent replication in Meta-Stroke confirmed the rs505922 association with stroke, beta (standard error, SE) = 0.066 (0.02), p = 0.001, a finding specific to large-vessel and cardioembolic stroke (p = 0.001 and p = < 0.001, respectively) but not seen with small-vessel stroke (p = 0.811). Interpretation: ABO gene variants are associated with large-vessel and cardioembolic stroke but not small-vessel disease. This work sheds light on the different pathogenic mechanis, Errata Annals of Neurology, 2014: 75 (1), 166-167. doi:10.1002/ana.24105
Published: 2013
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50. Is Period3 Genotype Associated With Sleep and Recovery in Patients With Disorders of Consciousness?

Author: Bedini, Gloria, Bersano, Anna, Sebastiano, Davide Rossi, Sattin, Davide, Ciaraffa, Francesca, Tosetti, Valentina, Brenna, Greta, Franceschetti, Silvana, Ciusani, Emilio, Leonardi, Matilde, Vela-Gomez, Jesus, Boncoraglio, Giorgio B., and Parati, Eugenio A.
Published: 2016
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