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The direct cross-couplings of diaryl sulfoxides with aryl bromides via C-S bond cleavage could be readily accomplished using nickel(II) as the catalyst, 1,2-bis(diphenylphosphino)ethane (dppe) as the ligand, and magnesium turnings as the reducing metal in THF, leading to the corresponding biaryls in moderate to good yields. The reaction exhibited a broad substrate scope and could be applied to a gram-scale synthesis. The "one-pot" reaction, which avoids the utility of presynthesized and moisture-labile organometallic compounds, is operationally simple and step-economic.

Background Deep learning (DL) algorithms could improve the classification of ovarian tumors assessed with multimodal US. Purpose To develop DL algorithms for the automated classification of benign versus malignant ovarian tumors assessed with US and to compare algorithm performance to Ovarian-Adnexal Reporting and Data System (O-RADS) and subjective expert assessment for malignancy. Materials and Methods This retrospective study included consecutive women with ovarian tumors undergoing gray scale and color Doppler US from January 2019 to November 2019. Histopathologic analysis was the reference standard. The data set was divided into training (70%), validation (10%), and test (20%) sets. Algorithms modified from residual network (ResNet) with two fusion strategies (feature fusion [hereafter, DL

We aimed to study the regulatory roles and mechanism of circular nuclear factor IX (circNFIX) in cancer growth and stemness properties of ovarian cancer (OC). CircNFIX and SH3RF3 levels in OC tissues and cells were tested by quantitative real-time PCR. RNase R treatment quantified circNFIX RNA stability. Molecular interaction among circNFIX, LIN28B, and SH3RF3 was predicted by bioinformatics software and validated through RNA immunoprecipitation (RIP) assay. The gain- or loss-experiments of circNFIX on capabilities of metastasis and stemness in vitro were assessed using Cell Counting Kit-8, Transwell, western blot, and sphere-formation assays. CircNFIX and SH3RF3 were markedly elevated in OC tissues and OC cells. Knocking down circNFIX repressed the proliferation, migration, invasion, and stemness properties of A2780 and SKOV3 cells. The RIP assay verified the direct binding relationship between LIN28B, circNFIX, and SH3RF3. Additionally, overexpression of circNFIX elevated the SH3RF3 expression, while this effect was reversed by LIN28B silence. Rescue experiments demonstrated that the overexpression of SH3RF3 reversed the knockdown of circNFIX on OC cells' proliferation, metastasis, and stemness properties. CircNFIX improved the mRNA stability and translation of SH3RF3 via recruiting LIN28B, thus promoting the proliferation, invasion, and stemness properties of OC cells in vitro.

Drug resistance presents a major obstacle in the treatment of genitourinary cancers. Exosomes as the medium of intercellular communication serve important biological functions and play essential roles in pathological processes, including drug response. Through the transfer of bioactive cargoes, exosomes can modulate drug resistance via multiple mechanisms. This review attempts to elucidate the mechanisms of exosomal cargoes with reference to tumor drug resistance, their role in genitourinary cancers, and their potential clinical applications as candidate biomarkers in liquid biopsy.

The impact of photosensitizer and wavelength on photooxidation of phytosterols (PS) in soymilk and the oxidative stability of lipid and protein was determined. The oxidation of lipid and the consumption of dissolved oxygen showed a close relationship with PS oxidation. Riboflavin (Rb) leads to extra oxidation of both lipid and protein, and chlorophyll (Chl) prefer to absorb to and change the structure of protein. The influence of Rb and Chl on PS degradation under different wavelengths of light in the range of 365-665 nm was measured. Original soymilk emulsion placed under UVA (365-375 nm) and violet (400-410 nm) light underwent the most PS deterioration, whereas riboflavin was responsible for oxidation around blue (465-475 nm) region and extra formation of 6β-OH sterols, and chlorophyll enriched emulsion was vulnerable under red (645-665 nm) light. The wavelength of light (UVA violet blue green red yellow) showed a great different effect in oxidation of PS and formation of phytosterol oxidation products (POPs). The UVA, violet, blue and red light gives rise to the prior five kind oxides of phytosterol: 6α-OH, 7α-OH, 7β-OH, 5,6β-epoxy and 7-keto.

MRI-guided laser interstitial thermal therapy (MRgLITT) is a novel treatment modality for focal cortical dysplasia (FCD). However, identifying the location and extent of subtle FCD by visual analysis during MRgLITT remains challenging.To introduce voxel-based morphometric MRI postprocessing into the procedure of MRgLITT for FCD-suspected lesions and assess the complementary value of the MRI postprocessing technique for the trajectory design and thermal parameter setting of MRgLITT.Junction and normalized fluid-attenuated inversion recovery signal intensity images were used to detect the gray-white matter junction blurring and cortical fluid-attenuated inversion recovery hyperintensity, respectively. According to the 2 postprocessing images, the region of interest (ROI) for ablation was drawn. The main principle of presurgical planning is that the trajectory of the laser fiber was designed as far as possible along the long axis of the ROI while the extent of planned ablation covered the entire ROI. The subsequent intraoperative procedure was performed under the guidance of the presurgical plan.Nine patients with epilepsy with FCD-suspected lesions underwent MRgLITT with the assistance of MRI postprocessing images. Among them, 4 patients were junction positive, 2 patients were normalized fluid-attenuated inversion recovery signal intensity positive, and the remaining 3 patients were positive for both. Postsurgical MRI demonstrated that the ROIs were ablated entirely in 7 patients. Engel Ia, Ib, and IV scores were obtained at 1-year follow-up for 6, 1, and 2 patients, respectively.MRI postprocessing provides complementary information for designing the laser fiber trajectory and subsequent ablation for FCDs.

With the development and progress of smart cities, ride-hailing have high passenger demand because of high spatial and temporal flexibility. However, when ride-hailing platforms dispatch vehicles, it finds that lots of vehicles wandering areas with no demand and areas with passenger demand have no service vehicles, resulting in increased vehicle costs, reduced benefits, and increased passenger waiting times. To solve this problem, it is necessary to accurately predict high demand areas to guide service vehicles to converge to these areas earlier, which helps to balance the demand and supply of the ride-sharing platform. Therefore, we propose a hierarchical clustering application algorithm based on distance and density (HDDCA) to construct virtual service areas, and a hybrid network based convolutional and time-series models is used for demand prediction. To improve the prediction accuracy, the correlation between virtual service areas is explored and used as the input of the prediction model to predict the demand for different virtual service areas in the next interval. In addition, the attention mechanism is also used to capture external factors with different weights. In this paper, experiments are conducted on the travel data set of Haikou City in 2017, and the results show that the prediction accuracy of this method is better than that of some typical models and existing deep neural network models, which validates the effectiveness.

We report on experimental measurements and theoretical calculations of Rabi oscillation distortion during rubidium clock transition in a compact cold-atom clock. The distortion of the Rabi oscillations of the clock transition caused by the magnetically sensitive transitions between magnetic sublevels is related to the duration and amplitude of the microwave pulse, the density distribution of cold atoms, and the biased magnetic field inside the microwave cavity. The theoretical calculations agreed well with the experimental results. The Rabi oscillation measurements are beneficial for determining the optimal parameters of a cold-atom clock and identifying the uniformity of the microwave field inside the cavity. This measurement can be extended to the atomic fountain clock and the vapor-cell atomic clock.

In this article, we provide a theoretical discussion on the interactions between a template molecule and functional monomer(s) in the preparation of molecularly imprinted polymers (MIPs). Density functional theory (DFT) was used to compute the 3D structures, natural bond orbital, and binding energy in the template–monomer(s) complexes. Histamine (HA) and 2-(trifluoromethyl)acrylic acid (TFMAA) were, respectively, selected as the template and the monomer. The computational process was performed according to B3LYP method with 6-311 + (d,p) basis set under the different HA–TFMAA ratios from 1:1 to 1:10. The computational results show that the HA–TFMAA complex at the ratio of 1:5 yields no consequence. Furthermore, the HA–TFMAA complex at the ratio of 1:5 allowed the minimum binding energy and the steadiest condition, with four hydrogen bonds. Configurational simulations and theoretical calculations of the template–monomer complex can be used as an appropriate guiding tool for manufacturing MIPs with high specificity and selectivity, thereby avoiding repeated experiments and wastage of substantial time and investment.

Hybrid rice has contributed greatly to global food security. Cytoplasmic male sterility (CMS) and photo/ thermo sensitive genic male sterility (P/TGMS) are genetic bases for three-line and two-line hybrid rice production, respectively. In contrast, (sub-) specific hybrid sterility (HS) is a major barrier for utilization of hybrid vigor of distant hybrid rice. Therefore, understanding the molecular regulatory mechanism of rice fertility is a key technical issue for hybrid rice industry, and a long-standing basic scientific issue for nuclear-cytoplasmic interaction and reproductive isolation. Chinese geneticists of plant sciences have made tremendous contributions on the molecular genetic basis of rice fertility related to hybrid rice production. Here, we review the development of hybrid rice production systems in China and summarize current advance on genetic basis and molecular mechanism of CMS, P/TGMS, and HS involved in hybrid rice. We also discuss problems of hybrid rice production in China and point out new direction for future utilization of heterosis in rice.

We propose a simple pumping method to increase the effective population of cold atoms in the clock state and investigate the factors which affect the pumping efficiency in cold atom systems. We report the theory and demonstrate the corresponding experiment in an 87Rb integrating sphere cold atom clock. The experimental results show that the population of cold atoms in the Zeeman sublevel |F = 2, mF = 0〉 is approximately 1.62 times that of the result using optical pumping alone. This method can also be applied to increase the effective population in any one of the target Zeeman sublevels in other cold atom systems.

An intermolecular iodoamination of allenamides with sulfonamides has been achieved under mild N-iodosuccinimide-mediated conditions delivering iodine-substituted allylamino Z-enamides in high regio- and stereoselectivity. These reactions proceed rapidly and tolerate a broad scope of substrates.

We developed a shoot multiplication protocol for Syringa reticulata Blume var. mandshurica Hara from in vitro cultured seedlings that derived from in vitro germinated seeds. The shoots could be induced on Murashige and Skoog (MS) medium with proper plant growth regulator combinations of 6-benzylaminopurine (BA) and indole-3-butyric acid (IBA). The better medium for shoot multiplication and growth was MS + 5 mg L−1 BA + 0.5 mg L−1 IBA + 20 g L−1 sucrose + 7 g L−1 agar, and the corresponding shoot induction rate was 75 %. The plantlets grew well after rooting on 1/2MS medium (macro-elements of MS medium are at half-strength) supplemented with 1 mg L−1 IBA, and the survival percentage was >80 % at 16 weeks after transplanting.

To assess the quality of Paeonia lactiflora roots by the multi-bioactive chemical markers.Total of66 Paeonia lactiflora roots samples were collected from Sichuan,Zhejiang and Anhui. An UHPLC-DAD technique was employed to quantify the contents of paeoniflorin,hydroypaeoniflorin,abiflorin,pentagalloyglucose,benzoypaeoni-florin,paeonol,gallic and catechin in these samples. These chemical components in each sample were also calculated by Principal Component Analysis( PCA).The eight bioactive components were good separated in 30 min on the UHPLC chromatogram. The correlation coefficients between peak areas and concentration for these bioactive components were not less than 0. 9990( n = 6). And their recoveries were in the range of95. 94% ~ 100. 92%( n = 6). The contents of paeoniflorin in Paeonia lactiflora roots samples collected from Sichuan,Zhejiang and Anhui were 40. 54 mg / g( n = 23),33. 09 mg / g( n = 22) and 39. 47 mg / g( n = 21),respectively. The values of PCA were 0. 4435( n = 23)for the samples from Sichuan,0. 0122( n = 22) for the samples from Zhejiang and- 4. 9850( n = 21) for the samples from Anhui. The content of paeoniflorin in biennial,triennial,four-year,five-year and six-year old Paeonia lactiflora roots were 24. 76( n = 2),37. 17( n= 16),37. 83( n = 23),39. 71( n = 16) and 37. 45 mg / g( n = 7),respectively.The developed method can accurately quantify the content of principal bioactive compounds in Paeonia lactiflora roots. The quality is various among Paeonia lactiflora roots cultivated in Sichuan, Zhejiang and Anhui on the basis of paeoniflorin content or the value of PCA,but the quality of Paeonia lactiflora roots cultivated in Sichuan is the best. Moreover, it is suggested Paeonia lactiflora roots should be harvested in third or fourth year based on the output and quality.

A new method was developed to synthesize iodine-substituted Z-enamides through N-iodosuccinimide-mediated intermolecular iodofunctionalization of allenamides with indoles, pyrroles, and furans. These reactions proceed rapidly and tolerate a broad scope of substrates. The conjugated sulfimide ion species probably acts as the key intermediate.

Background Measurement of the biomarker copeptin may help identify disease severity and risk of mortality for a various diseases. This study sought to determine the relationship between copeptin and all-cause mortality of patients with cardio-cerebrovascular disease. Methods Database of Medline and Web of Science were searched for studies with data involving the baseline copeptin levels and subsequent all-cause mortality outcomes. The pooled HRs of all-cause mortality were calculated and presented with 95% CI s. Subgroup analysis and sensitivity analysis were conducted to explore the possible sources of heterogeneity. Results Data from 14,395 participants were derived from 28 prospective studies. Higher copeptin significantly increased the risk of all-cause mortality (per unit copeptin: HR = 1.020, 95% CI = 1.004–1.036; log unit copeptin: HR = 2.884, 95% CI = 1.844–4.512; categorical copeptin: HR = 3.371, 95% CI = 2.077–5.472). Subgroup analysis indicated that the risk of all-cause death was higher in cerebrovascular patients (per unit copeptin: HR = 2.537, 95% CI = 0.956–6.731; log unit copeptin: HR = 3.419, 95% CI = 2.391–4.888) than cardiovascular patients (per unit copeptin: HR = 1.011, 95% CI = 1.002–1.020; log unit copeptin: HR = 2.009, 95% CI = 1.119–3.608). Conclusion Copeptin is associated with all-cause mortality of patients with cardiovascular and cerebrovascular disease. Our study suggests that copeptin seems to be a promising novel biomarker for prediction of mortality in cardio-cerebrovascular patients, especially for cerebrovascular patients.

：The phosphate is low silicon carbonate collophane, gangue mainly dolomite. Apply to the reverse flotation technology, determine one-stage roughing and one-stage scavenging reverse flotation test process,Collector with paraffin soap oxidated,Inhibitor use sulfuric acid. By the reverse flotation process contain. When the ore grade is 20.11%,under the flow sheet can research qualified phosphate product with content of 33.95% in concentration and recovery of 62.06%.

The collophane is in oolitic structure, and associates with the gangue intricately; and hence a good concentrate in performance is hardly produced only by rinsing, in order to achieve a full liberation, fine-grinding is needed for the cellophane. Based on the results of both direct and reverse flotation tests, it shows that reverse flotation is effective in the benefication of the apatite to a certain extent. When reverse flotation is used to dress the run-of-mine which contains 26.95%P2O5, a concentrate containing 32.69% P2O5 can be obtained at a recovery of 84.99%.

Apatite is a valuable component of the collophane taken from Yunnan, as it is in the shape of oolith and contains a lot of carbon, and hence an effective benefication of the apatite is difficult to be occurred by means of concentration. Based on the results of both direct and reverse flotation tests, it shows that reverse flotation is effective in the benefication of the apatite to a certain extent. When reverse flotation is employed to treat the run-of-mine at a grade of 18.77%, the concentrate containing P2O5 24.04% at a recovery of 62.58% can be produced.

As one of major environmental endocrine disruptors (EEDs), bisphenol A (BPA) has been drawn increasingly lots of people in the world, which is also widely identified as an indispensable raw chemical in plastics production, food cans and dental composites. With increasing demand and production capacity of BPA, moreBPAwill enter into and contaminate the environment. So it has become a challenge that excess BPA jeopardizes the health of human being. Considering a pretty low dose of BPA existing in the environment, some advanced analysis techniques have been carried out to analysis BPA, such as HLPC, GC-MS, LC-MS. Compared with other physical and chemical treatment technology, biological treatment technology has the advantage of low cost and high efficiency.

Electric Vehicles (EVs) have been the important tendency of future vehicle development. This paper discusses the performance and features of EVs with AC drive system, and analyzes two dominating control schemes of AC motor dynamic model, i.e., Vector Control (VC) and Direct Torque Control (DTC). Principles, advantages, disadvantages, research hot spots and developing directions of the two control schemes were carefully presented. Moreover, the paper points out that the two difficulties of AC drive system are improving low-speed performance and dynamic performance.

Efficient charge transport across proper interfacial contacts is crucial in organic solar cells. In this paper, the surface of the P3HT:PCBM bulk heterojunction (BHJ) layer is treated with ethylene...

Analysis of the surrounding rock stress distribution of neighborhood tunnel by using numerical simulation. Based on Cullen-Moore Theory, build a mathematical model of 1st principal stress σ1, 2nd principal stress σ2, internal friction angle φ, and cohesion c, then, make a expression of tunnel spacing safety factor A. Analysis a real tunnel project and evaluate its surrounding rock stability with safety factor A as the index. Propose an analysis method of judging the rationality of tunnel spacing.

Bus route accounting system with basic accounting methods and financial accounting principles of double-entry bookkeeping, the use of passenger daily, real-time billing, supplies, human resources systems to provide real-time data to a single line of commercial vehicles and accounting unit of revenue, costs , costs of collection, and ultimately accurate reflection of Busroutes, the fleet of the company's production operations financial condition.

The phosphate is low silicon carbonate collophane, gangue mainly dolomite. determine one-stage roughing and one-stage scavenging reverse flotation test process,the grinding fineness of 92.86% -200 mesh.Collector with paraffin soap oxidated,Three acid of sulfuric acid, hydrochloric acid, nitric acid as an inhibitor for contrast test,With concentration of 10% sulfuric acid 10000 g/t can research qualified phosphate product with content of 33.95% in concentration and recovery of 62.06%.

The value of the investment method is that investors who are anxious to pursue, there are many value investing methods have been proposed, but only a minority of the value investing method were proved to be effective. The study is based on messages generated defined value of the investment by Steidlmayer in 1984 proposed market profile theory. In order to extract trading behavior of dealer and product value by the huge financial trading information, the model used the trading data to capture feature patterns, and find the double distribution trend day generated by market profile. The experimental results show the single print as an entry point, and the reference to historical support and pressure line as an exit point. The results show the returns are 24.09 points and the accuracy achieved 57.45%.The results had shown the analysis model can find the investment goods real value from the huge trading information, and help investors obtain excess returns.

In practice, many physics principles have been employed to derive various models of financial engineering. However, few studies have been done on the feature selection of finance on time series data. The purpose of this paper is to determine if the behavior of market participant can be detected from historical price. For this purpose, the proposed algorithm utilizes back propagation neural network (BPNN) and works with new feature selection approach in data mining, which is used to generate more information of market behavior. This study is design for exchange-traded fund (ETF) to develop the day-trade strategy with high profit. The results show that BPNN hybridized with financial physical feature, as compared with the traditional approaches such as random walk, typically result in better performance.

Cerebral microbleeds (CMBs) increase future intracerebral hemorrhage (ICH) risk after ischemic stroke (IS) or transient ischemic attack (TIA). However, whether CMB-related ICH risk depends on CMB quantity, CMB location, or antithrombotic agents is unclear. We performed a systematic review and meta-analysis to investigate CMB-related ICH risk, stratifying patients according to the quantity of CMB, the location of CMB, and the type of antithrombotic therapy used.Literature databases were searched for prospective cohorts reporting ICH outcomes in patients with IS or TIA with baseline CMB evaluation. We calculated pooled relative ratios (RRs) for ICH among patients with and without CMBs. Pooled RRs of CMB-related ICH were further calculated in subgroups stratified by CMB quantity, CMB location, and antithrombotic therapy.Among the 10 included studies, the pooled RR of future ICH was 7.73 (95% confidence interval [CI], 4.07-14.70; P .001) in CMB versus non-CMB patients. Subgroup analysis revealed that compared with non-CMB patients, multiple-CMB patients were at an increased risk for future ICH (RR = 8.02; 95% CI, 3.21-20.01; P .001), whereas single-CMB patients did not incur this risk (RR = 2.33; 95% CI, .63-8.63; P = .205). A strong association was found between CMB presence and subsequent ICH in antiplatelet users (RR = 16.56; 95% CI, 3.68-74.42; P .001). Studies on CMB-related ICH according to CMB locations and in anticoagulant users are lacking for subgroup analysis.Our study revealed that patients with IS or TIA with multiple CMBs may incur a higher risk of future ICH, and the presence of CMBs in patients with IS or TIA using antiplatelet agents may significantly increase the subsequent ICH risk.