1. Infant birth weight and third trimester maternal plasma markers of vascular integrity: the MIREC study.
- Author
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Kumarathasan, Premkumari, Vincent, Renaud, Bielecki, Agnieszka, Blais, Erica, Blank, Katrin, Das, Dharani, Karthikeyan, Subramanian, Cakmak, Sabit, Fisher, Mandy, Arbuckle, Tye, and Fraser, William
- Subjects
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BIRTH weight , *THIRD trimester of pregnancy , *OXIDATIVE stress , *BIOMARKERS , *HIGH performance liquid chromatography , *GESTATIONAL age - Abstract
Background: There is paucity of information on mechanisms constituting adverse birth outcomes. We assessed here the relationship between vascular integrity and adverse birth effects. Methods and results: Third trimester maternal plasma (nā=ā144) from the Maternal-Infant Research on Environmental Chemicals Study (MIREC) was analysed for vascular, inflammatory and oxidative stress markers by HPLC-fluorescence, protein array and EIA method. Analysis of the <25th and >75th percentile birth weight subgroups revealed markers associated with birth weight (ETs, MMP-9, VEGF, and 8-isoPGF-2Ī±) and gestational age (ET-1, MMP-2, and VEGF). Conclusions: Mechanistic insights into adverse birth outcome pathways can be achieved by integrating information on multiple biomarkers, physiology using systems biology approach. [ABSTRACT FROM PUBLISHER]
- Published
- 2016
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