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Infant birth weight and third trimester maternal plasma markers of vascular integrity: the MIREC study.
- Source :
-
Biomarkers . May2016, Vol. 21 Issue 3, p257-266. 10p. - Publication Year :
- 2016
-
Abstract
- Background: There is paucity of information on mechanisms constituting adverse birth outcomes. We assessed here the relationship between vascular integrity and adverse birth effects. Methods and results: Third trimester maternal plasma (n = 144) from the Maternal-Infant Research on Environmental Chemicals Study (MIREC) was analysed for vascular, inflammatory and oxidative stress markers by HPLC-fluorescence, protein array and EIA method. Analysis of the <25th and >75th percentile birth weight subgroups revealed markers associated with birth weight (ETs, MMP-9, VEGF, and 8-isoPGF-2α) and gestational age (ET-1, MMP-2, and VEGF). Conclusions: Mechanistic insights into adverse birth outcome pathways can be achieved by integrating information on multiple biomarkers, physiology using systems biology approach. [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 1354750X
- Volume :
- 21
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Biomarkers
- Publication Type :
- Academic Journal
- Accession number :
- 114264662
- Full Text :
- https://doi.org/10.3109/1354750X.2015.1134663