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1. Properties and performance of the prototype instrument for the Pierre Auger Observatory

Author

Abraham, J., Aglietta, M., Aguirre, I.C., Albrow, M., Allard, D., Allekotte, I., Allison, P., Alvarez Muñiz, J., do Amaral, M.G., Ambrosio, M., Anchordoqui, L., Andrews, R., Anguiano, M., dos Anjos, J.C., Aramo, C., Argiro, S., Arisaka, K., Arteaga, J.C., Atulugama, S., Ave, M., Avila, G., Baggio, R., Bai, X., Barbosa, A.F., Barbosa, H.M.J., Barnhill, D., Barroso, S.L.C., Bauleo, P., Beatty, J., Beau, T., Becker, K.-H., Bellido, J.A., Bello, P., Bergmann, T., Berman, E., Bertou, X., Biermann, P., Billoir, P., Biral, R., Bluemer, H., Bohacova, M., Bollmann, E., Bonifazi, C., Boratav, M., Boselli, A., Brack, J., Brunet, J.-M., Bui-Duc, H., Cabrera, V., Camin, D.V., Capdevielle, J.-N., Carreño, A., Cartiglia, N., Caruso, R., de Carvalho, L.A., Casanova, S., Casimiro, E., Castellina, A., Castro, J., Cattaneo, P.W., Cazon, L., Cester, R., Chávez, N., Cheam, D., Chiavassa, A., Chinellato, J.A., Chiosso, M., Chou, A., Chye, J., Cillis, A., Civit, B., Claes, D., Clark, P.D.J., Clay, R.W., Cohen, F., Cordero, A., Cordier, A., Cormier, E., Cotzomi, J., Cotti, U., Coutu, S., Covault, C.E., Creusot, A., Cronin, J.W., Cuautle, M., Dagoret-Campagne, S., Dang-Quang, T., Da Silva, P., Darling, J., Darriulat, P., Daumiller, K., Dawson, B.R., de Bruijn, L., De Capoa, A., de Oliveira, M.A.L., de Souza, V., Della Selva, A., Deligny, O., Diaz, J.C., Dobrigkeit, C., D'Olivo, J.C., Dorofeev, A., Dova, M.T., Dye, A., DuVernois, M.A., Engel, R., Epele, L.N., Eschstruth, P., Escobar, C.O., Etchegoyen, A., Facal San Luis, P., Fauth, A.C., Fazzini, N., Fernández, A., Ferrero, A.M.J., Fick, B., Filevich, A., Filipčič, A., Fonte, R., Fulgione, W., Gámez, E., Garcia, B., Garcia, C.A., Geenen, H., Gemmeke, H., Germain-Renaud, C., Ghia, P.L., Gibbs, K., Giller, M., Gitto, J., Glass, H., Gómez Berisso, M., Gomez Vitale, P.F., González, J., Gora, D., Goodwin, A., Gouffon, P., Grassi, V., Grillo, A.F., Grunfeld, C., Grygar, J., Guarino, F., Guedes, G., Guerard, C., Gumbsheimer, R., Harton, J.L., Hasenbalg, F., Heck, D., Hernández, J.M., Hoffer, D., Hojvat, C., Homola, P., Horvat, M., Hrabovsky, M., Insolia, A., Jaminion, S., Jerónimo, Y., Jiang, L., Kaducak, M., Kampert, K.-H., Keilhauer, B., Kemp, E., Klages, H., Kleifges, M., Kleinfeller, J., Knapp, J., Kopmann, A., Kunka, N., Kutschera, M., Lachaud, C., Lapolla, M., Letessier-Selvon, A., Lhenry-Yvon, I., Lloyd-Evans, J., López, R., Lopez Aguera, A., Lucano, M., Luna, R., Ma, Y., Manceñido, M.E., Manfredi, P.F., Manhaes, L., Mantsch, P., Mariazzi, A.G., Markus, M.J., Martin, G., Martineau, O., Martinez, J., Martinez, N., Martı́nez, O., Mathes, H.-J., Matthews, J.A.J., Matthews, J., Matthiae, G., Marques, E., Matussek, P., Maurin, G., Maurizio, D., Mazur, P., McCauley, T., McEwen, M., McNeil, R.R., Medina, C., Medina, M.C., Medina-Tanco, G., Melo, D., Melocchi, M., Menichetti, E., Menshikov, A., Meyer, F., Meyhandan, R., Meza, J.C., Miele, G., Miller, W., Mohammed, M., Monnier-Ragaigne, D., Morello, C., Moreno, E., Mostafa, M., Mussa, R., Nassini, H., Navarra, G., Nellen, L., Nerling, F., Newman-Holmes, C., Nicotra, D., Nigro, S., Nitz, D., Nogima, H., Nosek, D., Nuñez, M., Ohnuki, T., Olinto, A., Ostaptchenko, S., Palatka, M., Parente, G., Parizot, E., Pasaye, E.H., Pastrone, N., Patel, M., Paul, T., Pedraza, I., Pekala, J., Pelayo, R., Pepe, I.M., Pérez-Lorenzana, A., Perrone, L., Peshman, N., Petrera, S., Petrinca, P., Pham-Ngoc, D., Pham-Trung, P., Pierog, T., Pisanti, O., Playez, N., Ponce, E., Porter, T.A., Prado Junior, L., Privitera, P., Prouza, M., Pryke, C.L., Rafert, J.B., Raia, G., Ranchon, S., Ratti, L., Ravignani, D., Re, V., Reis, H.C., Reucroft, S., Revenue, B., Richter, M., Ridky, J., Risi, A., Risse, M., Rizi, V., Roberts, M.D., Robledo, C., Rodriguez, G., Rodriquez, J., Rodriquez Martino, J., Román, S., Rosa, L., Roth, M., Rovero, A.C., Salazar, H., Salina, G., Sanchez, F., Santander, M., dos Santos, L.G., Sato, R., Schovanek, P., Scherini, V., Sciutto, S.J., Sequeiros-Haddad, G., Shellard, R.C., Shibuya, E., Siguas, F.V., Slater, W., Smetniansky-De Grande, N., Smith, K., Snow, G.R., Sommers, P., Song, C., Spinka, H., Suarez, F., Suomijärvi, T., Supanitsky, D., Swain, J., Szadkowski, Z., Tamashiro, A., Thornton, G.J., Thouw, T., Ticona, R., Tkaczyk, W., Todero Peixoto, C.J., Tripathi, A., Tristram, G., Trombley, M., Tscherniakhovski, D., Tuckey, P., Tunnicliffe, V., Urban, M., Uribe Estrada, C., Valdés, J.F., Vargas, A., Vargas, C., Vazquez, R., Veberič, D., Veiga, A., Velarde, A., Vernotte, F., Verzi, V., Videla, M., Vigorito, C., Villaseñor, L.M., Vlcek, M., Voyvodic, L., Vo-Van, T., Waldenmaier, T., Walker, P., Warner, D., Watson, A.A., Wiebusch, Ch., Wieczorek, G., Wilczynska, B., Wilczynski, H., Wild, N.R., Yamamoto, T., Zas, E., Zavrtanik, D., Zavrtanik, M., Zepeda, A., Zhang, C., and Zhu, Q.

Published
2004
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4. OBSERVATION OF THE MOON SHADOW USING A NEW RECONSTRUCTION TECHNIQUE IN THE CLUE EXPERIMENT

Author

Bartoli, B., Bastieri, D., Bigongiari, C., Biral, R., maria agnese ciocci, Cresti, M., Dokoutchaeva, V., Kartashov, D., Liello, F., Malakhov, N., Mariotti, M., Marsella, G., Menzione, A., Paoletti, R., Peruzzo, L., Piccioli, A., Pegna, R., Rosso, F., Saggion, A., Sartori, G., Sbarra, C., Scribano, A., Smogailov, E., Stamerra, A., Turini, N., Bartoli, Bruno, D., Bastieri, C., Bigongiari, R., Biral, M. A., Ciocci, M., Cresti, V., Dokoutchaeva, D., Kartashov, F., Liello, N., Malakhov, M., Mariotti, G., Marsella, A., Menzione, R., Paoletti, L., Peruzzo, A., Piccioli, R., Pegna, F., Rosso, A., Saggion, G., Sartori, C., Sbarra, A., Scribano, E., Smogailov, A., Stamerra, N., Turini, Bartoli, B, Bastieri, D, Bigongiari, C, Biral, R, Ciocci, Ma, Cresti, M, Dokoutchaeva, V, Kartashov, D, Liello, F, Malakhov, N, Mariotti, M, Marsella, Giovanni, Menzione, A, Paoletti, R, Peruzzo, L, Piccioli, A, Pegna, R, Rosso, F, Saggion, A, Sartori, G, Sbarra, C, Scribano, A, Smogailov, E, Stamerra, A, and Turini, N.

Subjects
TELESCOPES, Cosmic rays
Abstract

The CLUE experiment, located in La Palma island at 2200 m a.s.l.. is an array of 3x3 telescope, detecting the UV (190-230 nm) Cerenkov light produced by atmospheric showers. Due to the higher atmospheric absorption in the UV range than in the visible one, CLUE cannot apply existing algorithms normally used in IACT experiments to determine primary cosmic ray direction. In this paper we present a new method developed by CLUE. The algorithm performances were evaluated using simulated showers. CLUE experiment collected data in the last, two years pointing to AGN sources and to Moon. The preliminary results obtained using the new technique on Crab Nebula and on Markarian 421 were presented in a previous paper. Here, we present the preliminary observation of Moon Shadow employing the new method. As described in the paper, we expect in a near future. improvements on AGN sources and on Moon Shadow measurement.

Published
2001

5. THE CLUE TRIGGER: A VME BASED TWO LEVEL TRIGGER FOR VHE EXPERIMENTS

Author

Mariotti, Mose', Alexandreas, D., Bartoli, B., Bastieri, Denis, Biral, R., Bigongiari, Ciro, Chiarelli, G., Cappuccio, R., Cocca, E., Cresti, M., Liello, F., Menzione, A., Marsella, G., O'Connor, D., Parlavecchio, G., Paoletti, R., Peruzzo, Luigi, Rosso, F., Sacco, R., Saggion, Antonio, Sartori, G., Sbarra, C., Scribano, A., Smith, D., Stamerra, A., Turini, N., Infn, F. ZETTI PADUA U., Infn, PADUA NAPLES U., Infn, NAPLES PISA U., Infn, PISA TRIESTE U., TRIESTE CAMPINAS STATE, U., Imecc, D., Alexandrea, Bartoli, Bruno, D., Bastieri, R., Biral, C., Bigongiari, G., Chiarelli, R., Cappuccio, E., Cocca, M., Cresti, F., Liello, M., Mariotti, A., Menzione, G., Marsella, D., O'Connor, G., Parlavecchio, R., Paoletti, L., Peruzzo, F., Rosso, R., Sacco, A., Saggion, G., Sartori, C., Sbarra, A., Scribano, D., Smith, A., Stamerra, N., Turini, F., Zetti, Alexandreas, D, Bartoli, B, Bastieri, D, Biral, R, Bigongiari, C, Chiarelli, G, Cappuccio, R, Cocca, E, Cresti, M, Liello, F, Mariotti, M, Menzione, A, Marsella, Giovanni, O'Connor, D, Parlavecchio, G, Paoletti, R, Peruzzo, L, Rosso, F, Sacco, R, Saggion, A, Sartori, G, Sbarra, C, Scribano, A, Smith, D, Stamerra, A, Turini, N, and Zetti, F.

Subjects
Physics, Nuclear and High Energy Physics, business.industry, Astrophysics::High Energy Astrophysical Phenomena, Low resolution, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, Astrophysics::Instrumentation and Methods for Astrophysics, Coincidence, law.invention, IMAGING CHERENKOV DETECTOR, Telescope, law, Level trigger, business, Instrumentation, TRIGGER, Computer hardware, Cherenkov radiation, VMEbus
Abstract

We describe a trigger architecture developed for shower selection in the CLUE Cherenkov telescopes. The selection is made first in each telescope of the array looking at the low resolution images produced by fast electronics, than requiring temporal coincidence between units. Big effort has been put to simplify the programming of trigger configurations to help the user to switch easily between different observational and calibration requests. (C) 1998 Published by Elsevier Science B.V. All rights reserved.

Published
1998

6. STATUS-REPORT ON CLUE

Author

Mariotti, Mose', Alexandreas, D., Bartoli, B., Bastieri, Denis, Bedeschi, F., Bertolucci, E., Bigongiari, Ciro, Biral, R., Busetto, Giovanni, Centro, S., Chiarelli, G., Cocca, E., Cresti, M., Liello, F., Marsella, G., Menzione, A., O'Connor, D. J., Nicoletto, M., Paoletti, R., Peruzzo, Luigi, Pesci, A., Pugno, R., Saggion, Antonio, Sartori, Giorgio, Sbarra, C., Scribano, A., Smith, D. A., Turini, N., Infn, F. ZETTI NAPLES U., Infn, NAPLES PADUA U., Infn, PADUA PISA U., Infn, PISA SIENA U., TRIESTE TRIESTE, U., Alexandreas, D, Bartoli, B, Bastieri, D, Bedeschi, F, Bertolucci, E, Bigongiari, C, Biral, R, Busetto, G, Centro, S, Chiarelli, G, Cocca, E, Cresti, M, Liello, F, Mariotti, M, Marsella, Giovanni, Menzione, A, Oconnor, Dj, Nicoletto, M, Paoletti, R, Peruzzo, L, Pesci, A, Pugno, R, Saggion, A, Sartori, G, Sbarra, C, Scribano, A, Smith, Da, Turini, N, Zetti, F., D., Alexandrea, Bartoli, Bruno, D., Bastieri, F., Bedeschi, E., Bertolucci, C., Bigongiari, R., Biral, G., Busetto, S., Centro, G., Chiarelli, E., Cocca, M., Cresti, F., Liello, M., Mariotti, G., Marsella, A., Menzione, D. J., Oconnor, M., Nicoletto, R., Paoletti, L., Peruzzo, A., Pesci, R., Pugno, A., Saggion, G., Sartori, C., Sbarra, A., Scribano, D. A., Smith, N., Turini, and F., Zetti

Subjects
Physics, Nuclear and High Energy Physics, Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, Astrophysics::Instrumentation and Methods for Astrophysics, HEGRA, Cosmic ray, RAYS, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics, Status report, Skylight, IMAGING CHERENKOV DETECTOR, Duty cycle, Cosmic rays, Detector array, Instrumentation, Cherenkov radiation
Abstract

The CLUE experiment uses a new cosmic ray detector array planned to operate for the next decade. It utilises a MWPC chambers sensitive to UV, to image Cherenkov radiation produced in cosmic ray showers. This approach is unique in that the instrument is insensitive to skylight backgrounds, has a threshold similar to that of visible Cherenkov experiments but a longer duty cycle. These features make possible a class of interesting cosmic ray physics experiments. The CLUE experiment has started operation with two of the ten telescopes that are foreseen for its beginning. These telescopes are at present at Roque de Los Muchachos in the Canary Islands, in the same site as the HEGRA experiment. A description of the telescopes is given and some data on the tests performed are presented.

Published
1995

7. The CLUE new UV detector (presented by A. Stamerra)

Author

Bartoli, B., Bastieri, D., Bigongiari, C., Biral, R., Ciocci, MARIA AGNESE, Cresti, M., Dokoutchaeva, V., Kartashov, D., Liello, F., Malakhov, N., Mariotti, M., Marsella, G., Menzione, A., Paoletti, R., Peruzzo, L., Piccioli, A., Pegna, R., Rosso, F., Saggion, A., Sartori, G., Sbarra, C., Scribano, A., Stamerra, Antonio, and Turini, Nicola

Subjects
CHERENKOV TELESCOPE, Detectors
Published
2001

9. The CLUE experiment running with 8 telescopes; observations of gamma sources and runs on Moon.

Author

Bastieri, D., Bartoli, B., Bigongiari, C., Biral, R., Ciocci, M. A., Cosulich, D., Cresti, M., Kartashov, D., Liello, F., Malakov, N., Mariotti, M., Marsella, G., Menzione, A., Paoletti, R., Parlavecchio, G., Peruzzo, L., Piccioli, A., Rosso, F., Sacco, R., and Saggion, A.

Subjects
CHERENKOV radiation, GAMMA rays
Abstract

The CLUE experiment is presently an array of 8 telescopes detecting UV Cherenkov light from atmospheric showers. Preliminary results from the last 2 years of data taking are shown. 1998 campaigns on Markarian 421, Markarian 501 and the Crab Nebula. The 1998–1999 high-statistics campaign with the telescopes aiming directly at the Moon will be also presented. The last item is related with the measurement of the ratio p˜/p in cosmic rays, in its turn of prominent importance to validate early Universe models. © 2000 American Institute of Physics. [ABSTRACT FROM AUTHOR]

Published
2000

10. The CLUE trigger: a VME based two level trigger for VHE experiments

Author

Alexandreas, D., primary, Bartoli, B., additional, Bastieri, D., additional, Biral, R., additional, Bigongiari, C., additional, Chiarelli, G., additional, Cappuccio, R., additional, Cocca, E., additional, Cresti, M., additional, Liello, F., additional, Mariotti, M., additional, Menzione, A., additional, Marsella, G., additional, O'Connor, D., additional, Parlavecchio, G., additional, Paoletti, R., additional, Peruzzo, L., additional, Rosso, F., additional, Sacco, R., additional, Saggion, A., additional, Sartori, G., additional, Sbarra, C., additional, Scribano, A., additional, Smith, D., additional, Stamerra, A., additional, Turini, N., additional, and Zetti, F., additional

Published
1998
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11. The CLUE experiment operating with 4 telescopes in La Palma

Author

Alexandreas, D, primary, Bartoli, B, additional, Bastieri, D, additional, Biral, R, additional, Bigongiari, C, additional, Chiarelli, G, additional, Cappuccio, R, additional, Cocca, E, additional, Cresti, M, additional, Liello, F, additional, Mariotti, M, additional, Menzione, A, additional, Marsella, G, additional, O’Connor, D, additional, Parlavecchio, G, additional, Paoletti, R, additional, Peruzzo, L, additional, Rosso, F, additional, Sacco, R, additional, Saggion, A, additional, Sartori, G, additional, Sbarra, C, additional, Scribano, A, additional, Smith, D, additional, Stamerra, A, additional, Turini, N, additional, and Zetti, F, additional

Published
1998
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12. Status report on CLUE

Author

Alexandreas, D, primary, Bartoli, B, additional, Bastieri, D, additional, Bedeschi, F, additional, Bertolucci, E, additional, Bigongiari, C, additional, Biral, R, additional, Busetto, G, additional, Centro, S, additional, Chiarelli, G, additional, Cocca, E, additional, Cresti, M, additional, Liello, F, additional, Mariotti, M, additional, Marsella, G, additional, Menzione, A, additional, O'Connor, D.J, additional, Nicoletto, M, additional, Paoletti, R, additional, Peruzzo, L, additional, Pesci, A, additional, Pugno, R, additional, Saggion, A, additional, Sartori, G, additional, Sbarra, C, additional, Scribano, A, additional, Smith, D.A, additional, Turini, N, additional, and Zettti, F, additional

Published
1995
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16. c

Author

Biral, R. R., Consani, S., and Bertolini, Paolo

Published
1971

17. Observation of γ-sources using a new reconstruction technique in the CLUE experiment

Author

M. Cresti, F. Liello, E. Smogailov, Antonio Stamerra, R. Paoletti, B. Bartoli, M. Mariotti, A. Scribano, A. Menzione, F. Rosso, Maria Agnese Ciocci, L. Peruzzo, A. Saggion, R. G. Pegna, G. Sartori, C. Sbarra, N. Turini, A. Piccioli, D. Kartashov, Denis Bastieri, N. Malakhov, C. Bigongiari, V. Dokoutchaeva, R. Biral, G. Marsella, Bartoli, B, Bastieri, D, Bigongiari, C, Biral, R, Ciocci, Ma, Cresti, M, Dokoutchaeva, V, Kartashov, D, Liello, F, Malakhov, N, Mariotti, M, Marsella, Giovanni, Menzione, A, Paoletti, R, Peruzzo, L, Piccioli, A, Pegna, R, Rosso, F, Saggion, A, Sartori, G, Sbarra, C, Scribano, A, Smogailov, E, Stamerra, A, Turini, N., Bartoli, Bruno, D., Bastieri, C., Bigongiari, R., Biral, M. A., Ciocci, M., Cresti, V., Dokoutchaeva, D., Kartashov, F., Liello, N., Malakhov, M., Mariotti, G., Marsella, A., Menzione, R., Paoletti, L., Peruzzo, A., Piccioli, R., Pegna, F., Rosso, A., Saggion, G., Sartori, C., Sbarra, A., Scribano, E., Smogailov, A., Stamerra, and N., Turini

Subjects
Physics, Nuclear and High Energy Physics, Astronomy, IACT, Cosmic ray, Astrophysics, gamma ray astronomy, Cosmic rays, IMAGING CHERENKOV DETECTOR, Signal on, Atomic and Molecular Physics, and Optics, law.invention, Telescope, Crab Nebula, Cherenkov telescope, cosmic rays, law, Shadow, TELESCOPES, Visible range, Atmospheric absorption
Abstract

The CLUE experiment, located in La Palma island at 2200 m a.s.l., is an array of 3×3 telescope, detecting the UV (190 – 230 nm ) Cerenkov light produced by atmospheric showers. Since atmospheric absorption in the UV range is higher than in the visible range, CLUE cannot apply existing algorithms normally used in IACT experiments to determine primary cosmic ray direction. In this paper we present a new method developed by CLUE. The algorithm performances were evaluated using simulated showers. Using the new technique, preliminary results of last two years observational campaigns on the Crab Nebula and on Markarian 421 are presented, showing a clear signal on both sources. The CLUE experiment collected also data with the telescopes aiming directly at the Moon: we expect improvements also on the Moon Shadow measurement adopting the new method.

Published
2001

18. The CLUE experiment operating with 4 telescopes in La Palma

Author

Nicola Turini, F. Liello, R. Cappuccio, R. Sacco, D. Alexandreas, E. Cocca, R. Paoletti, F. Zetti, F. Rosso, Denis Bastieri, A. Menzione, R. Biral, Antonio Stamerra, M. Cresti, Giorgio Chiarelli, Carla Sbarra, L. Peruzzo, Ciro Bigongiari, G. Marsella, A. Scribano, G. Sartori, B. Bartoli, A. Saggion, D. J. O'Connor, G. Parlavecchio, David J. Smith, Mosè Mariotti, D., Alexandrea, Bartoli, Bruno, D., Bastieri, R., Biral, C., Bigongiari, G., Chiarelli, R., Cappuccio, E., Cocca, M., Cresti, F., Liello, M., Mariotti, A., Menzione, G., Marsella, D., O'Connor, G., Parlavecchio, R., Paoletti, L., Peruzzo, F., Rosso, R., Sacco, A., Saggion, G., Sartori, C., Sbarra, A., Scribano, D., Smith, A., Stamerra, N., Turini, F., Zetti, Alexandreas, D, Bartoli, B, Bastieri, D, Biral, R, Bigongiari, C, Chiarelli, G, Cappuccio, R, Cocca, E, Cresti, M, Liello, F, Mariotti, M, Menzione, A, Marsella, Giovanni, O'Connor, D, Parlavecchio, G, Paoletti, R, Peruzzo, L, Rosso, F, Sacco, R, Saggion, A, Sartori, G, Sbarra, C, Scribano, A, Smith, D, Stamerra, A, Turini, N, and Zetti, F.

Subjects
Physics, Nuclear and High Energy Physics, ATMOSPHERIC CHERENKOV TELESCOPE, Meteorology, Astrophysics::High Energy Astrophysical Phenomena, Detector, Astrophysics::Instrumentation and Methods for Astrophysics, Astronomy, HEGRA, Astrophysics::Cosmology and Extragalactic Astrophysics, IMAGING CHERENKOV DETECTOR, cosmic rays, VHE Gamma ray, Astrophysics::Earth and Planetary Astrophysics, Instrumentation, Astrophysics::Galaxy Astrophysics, Cosmic rays
Abstract

The CLUE experiment has started operation with four of the nine telescopes that are foreseen for its beginning. These telescopes are at present at Rogue de Los Muchachos in the Canary Islands, in the same site as the HEGRA experiment. In winter 1997 we started taking data with the telescopes pointing directly at the moon. A description of the telescopes and the performance of the detector are given. (C) 1998 Elsevier Science B.V. All rights reserved.

Published
1998

19. Cohort Profile Update: The Swiss Eosinophilic Esophagitis Cohort Study (SEECS).

Author

El-Khoury JW, Safroneeva E, Saner C, Rossel JB, Trelle S, Zwahlen M, Biedermann L, Kreienbuehl A, Greuter T, Schreiner P, Netzer P, Franke A, Brand S, Hasler C, Aepli P, Burri E, Weber A, Sempoux C, Biral R, Jochum W, Diebold J, Willi N, Straumann A, and Schoepfer AM

Abstract

Introduction: The Swiss Eosinophilic Esophagitis Cohort Study (SEECS) is a national cohort that was established in 2015 with the aim of improving quality of care of affected adults with eosinophilic esophagitis (EoE). Between 2020 and 2022, paper questionnaires were gradually replaced by fully electronic data capture using Research Electronic Data Capture (REDCap ® ) software. We aim to provide an update of the SEECS 8 years after its launch., Methods: The SEECS prospectively includes adults (≥18 years of age) with EoE as well as patients with gastroesophageal reflux disease (GERD) and healthy control subjects (HC). Upon inclusion and follow-up (typically once every 12-18 months), patients and physicians complete REDCap ® questionnaires, which are available in German, French, and English. Patient-reported outcomes (PROs) and biologic findings are assessed on the same day using validated instruments (EEsAI PRO for symptoms; EoE-QoL-A for QoL; EREFS for endoscopic activity; modified EoE-HSS for histologic activity). The SEECS biobank includes biosamples from patients with EoE, GERD, and HC., Results: As of July 2023, the SEECS included 778 patients (716 [92%] with EoE, 29 [3.8%] with GERD, and 33 [4.2%] HC; 559/778 [71.9%] were male). Mean age ± SD (years) at enrollment according to diagnosis was as follows: EoE 41.9 ± 12.9, GERD 53.6 ± 16.4, HC 51.7 ± 17.2. Concomitant GERD was found in 200 patients (27.9%) of the EoE cohort. Concomitant allergic disorders (asthma, rhinoconjunctivitis, eczema) were present in 500 EoE patients (74.4%). At inclusion, 686 (95.8%) of EoE patients were on ongoing treatment (orodispersible budesonide tablet [Jorveza ® ] in 281 patients [41%]; budesonide or fluticasone syrup or swallowed powder in 290 patients [42.3%]; proton-pump inhibitors in 162 patients [23.6%]; elimination diets in 103 patients [15%]; and esophageal dilation at last visit in 166 patients [24.2%]). A total of 8,698 biosamples were collected, of which 1,395 (16%) were used in the framework of translational research projects., Conclusion: SEECS continuously grows and is operational using fully electronic data capture. SEECS offers up-to-date epidemiologic and real-world clinical efficacy data on EoE and promotes clinical and translational research., Competing Interests: Jeanine Wakim has no relevant financial, professional, or personal relationships to disclose. Ekaterina Safroneeva reports (i) consulting fees from Avir Pharma, Inc., Aptalis Pharma, Inc., Celgene Corp., Novartis, AG, and Regeneron Pharmaceuticals Inc.; (ii) being an employee of Tillotts Pharma AG. Catherine Saner has no relevant financial, professional, or personal relationships to disclose. Jean-Benoit Rossel has no relevant financial, professional, or personal relationships to disclose. Sven Trelle has no relevant financial, professional, or personal relationships to disclose. Marcel Zwahlen has no relevant financial, professional, or personal relationships to disclose. Luc Biedermann received consulting fees and/or speaker fees and/or research grants from Adare/Ellodi Pharmaceuticals, Inc., AstraZeneca, AG, Switzerland, Receptos-Celgene-BMS, Dr. Falk Pharma, GmbH, Germany, Glaxo Smith Kline, AG, Nestlé S. A., Switzerland, Novartis, AG, Switzerland, and Regeneron-Sanofi Pharmaceuticals. Andrea Kreienbuehl has no relevant financial, professional, or personal relationships to disclose. Thomas Greuter received consulting fees and/or speaker fees and/or research grants from Adare/Ellodi Pharmaceuticals, Inc., AstraZeneca, AG, Switzerland, Receptos-Celgene-BMS, Dr. Falk Pharma, GmbH, Germany, Glaxo Smith Kline, AG, Nestlé S. A., Switzerland, Novartis, AG, Switzerland, and Regeneron-Sanofi Pharmaceuticals. Philipp Schreiner received consulting fees and/or speaker fees from Dr. Falk Pharma, GmbH, Takeda, Regerenon-Sanofi Pharmaceuticals, AbbVie, Janssen-Cilag, Receptos-Celgene-BMS. Peter Netzer has no relevant financial, professional, or personal relationships to disclose. Annett Franke has no relevant financial, professional, or personal relationships to disclose. Stephan Brand has no relevant financial, professional, or personal relationships to disclose. Chantal Hasler has no relevant financial, professional, or personal relationships to disclose. Patrick Aepli has no relevant financial, professional, or personal relationships to disclose. Emanuel Burri has no relevant financial, professional, or personal relationships to disclose. Achim Weber has no relevant financial, professional, or personal relationships to disclose. Christine Sempoux has no relevant financial, professional, or personal relationships to disclose. Ruggero Biral has no relevant financial, professional, or personal relationships to disclose. Wolfram Jochum has no relevant financial, professional, or personal relationships to disclose. Joachim Diebold has no relevant financial, professional, or personal relationships to disclose. Niels Willi has no relevant financial, professional, or personal relationships to disclose. Alex Straumann received consulting fees and/or speaker fees and/or research grants from Adare/Ellodi Pharmaceuticals, Inc., AstraZeneca, AG, Switzerland, Receptos-Celgene-BMS, Dr. Falk Pharma, GmbH, Germany, Glaxo Smith Kline, AG, Nestlé S. A., Switzerland, Novartis, AG, Switzerland, and Regeneron-Sanofi Pharmaceuticals. Alain Schoepfer received consulting fees and/or speaker fees and/or research grants from Adare/Ellodi Pharmaceuticals, Inc., AstraZeneca, AG, Switzerland, Receptos-Celgene-BMS, Dr. Falk Pharma, GmbH, Germany, Glaxo Smith Kline, AG, Nestlé S. A., Switzerland, Novartis, AG, Switzerland, and Regeneron-Sanofi Pharmaceuticals., (© 2024 The Author(s). Published by S. Karger AG, Basel.)

Published
2024
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20. Pathologist Computer-Aided Diagnostic Scoring of Tumor Cell Fraction: A Swiss National Study.

Author

Frei AL, Oberson R, Baumann E, Perren A, Grobholz R, Lugli A, Dawson H, Abbet C, Lertxundi I, Reinhard S, Mookhoek A, Feichtinger J, Sarro R, Gadient G, Dommann-Scherrer C, Barizzi J, Berezowska S, Glatz K, Dertinger S, Banz Y, Schoenegg R, Rubbia-Brandt L, Fleischmann A, Saile G, Mainil-Varlet P, Biral R, Giudici L, Soltermann A, Chaubert AB, Stadlmann S, Diebold J, Egervari K, Bénière C, Saro F, Janowczyk A, and Zlobec I

Subjects
Humans, Switzerland, Pathologists, Computers
Abstract

Tumor cell fraction (TCF) estimation is a common clinical task with well-established large interobserver variability. It thus provides an ideal test bed to evaluate potential impacts of employing a tumor cell fraction computer-aided diagnostic (TCFCAD) tool to support pathologists' evaluation. During a National Slide Seminar event, pathologists (n = 69) were asked to visually estimate TCF in 10 regions of interest (ROIs) from hematoxylin and eosin colorectal cancer images intentionally curated for diverse tissue compositions, cellularity, and stain intensities. Next, they re-evaluated the same ROIs while being provided a TCFCAD-created overlay highlighting predicted tumor vs nontumor cells, together with the corresponding TCF percentage. Participants also reported confidence levels in their assessments using a 5-tier scale, indicating no confidence to high confidence, respectively. The TCF ground truth (GT) was defined by manual cell-counting by experts. When assisted, interobserver variability significantly decreased, showing estimates converging to the GT. This improvement remained even when TCFCAD predictions deviated slightly from the GT. The standard deviation (SD) of the estimated TCF to the GT across ROIs was 9.9% vs 5.8% with TCFCAD (P < .0001). The intraclass correlation coefficient increased from 0.8 to 0.93 (95% CI, 0.65-0.93 vs 0.86-0.98), and pathologists stated feeling more confident when aided (3.67 ± 0.81 vs 4.17 ± 0.82 with the computer-aided diagnostic [CAD] tool). TCFCAD estimation support demonstrated improved scoring accuracy, interpathologist agreement, and scoring confidence. Interestingly, pathologists also expressed more willingness to use such a CAD tool at the end of the survey, highlighting the importance of training/education to increase adoption of CAD systems., (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.)

Published
2023
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21. Vertebral alveolar echinococcosis-a case report, systematic analysis, and review of the literature.

Author

Meinel TR, Gottstein B, Geib V, Keel MJ, Biral R, Mohaupt M, and Brügger J

Subjects
Aged, Albendazole therapeutic use, Animals, Anthelmintics therapeutic use, Echinococcosis parasitology, Female, Humans, Radiography, Abdominal, Echinococcosis complications, Echinococcosis pathology, Echinococcus multilocularis, Spine parasitology, Spine pathology
Abstract

Alveolar echinococcosis caused by Echinococcus multilocularis is an infrequent zoonosis with a high degree of disability, morbidity, and mortality, especially in disease clusters of the northern hemisphere. The diagnosis is complicated by extended incubation time, diverse clinical manifestations, and mimicking of differential diagnoses. The primary organ affected is the liver, but extrahepatic disease is possible, with vertebral involvement in only a few dozen cases described worldwide. Although vertebral alveolar echinococcosis seems to be rare, it might be under diagnosed, and it might be seen more often as the number of people with immunocompromised conditions increases. Recognition of this syndrome is crucial, because advances in medical and surgical management strategies since the introduction of benzimidazole in 1976 have controlled and relieved symptoms in most cases. In this Grand Round, we present the case of a 75-year-old woman who was referred for biopsy of a lumbar lesion 3 months after she was diagnosed with chronic myeloid leukaemia. The diagnosis of hepatic alveolar echinococcosis with metastasis to the lumbar spine and paravertebral region as well as the brain was confirmed by biopsy, PCR, and serology. The patient was given albendazole and referred for palliative surgery with the aim of pain control. Clinical features of the case are presented and discussed in the context of the literature. This case and review illustrate the complexity of extrahepatic alveolar echinococcosis manifestations and the necessity of an interdisciplinary approach., (Copyright © 2018 Elsevier Ltd. All rights reserved.)

Published
2018
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22. Severe recurrent hypoglycemia after gastric bypass surgery.

Author

Z'graggen K, Guweidhi A, Steffen R, Potoczna N, Biral R, Walther F, Komminoth P, and Horber F

Subjects
Adult, Dumping Syndrome diagnosis, Dumping Syndrome etiology, Dumping Syndrome surgery, Female, Follow-Up Studies, Humans, Hypoglycemia pathology, Hypoglycemia prevention & control, Laparoscopy, Male, Middle Aged, Pancreatectomy, Recurrence, Severity of Illness Index, Gastric Bypass adverse effects, Hypoglycemia etiology, Obesity, Morbid surgery
Abstract

Background: Bariatric surgery is, at present, the most effective method to achieve major, long-term weight loss in severely obese patients. Recently, severe recurrent symptomatic hyperinsulinemic hypoglycemia was described as a consequence of gastric bypass surgery (GBS) in a small series of patients with severe obesity. Pancreatic nesidioblastosis, a hyperplasia of islet cells, was postulated to be the cause, and subtotal or total pancreatectomy was the suggested treatment., Methods: We observed that severe, disabling hypoglycemia after GBS occurred only in patients with loss of restriction. Whether restoration of gastric restriction might treat severe, recurrent hypoglycemia after GBS is unknown., Results: Therefore, gastric restriction was restored by surgical placement of a silastic ring (n = 8, first two patients with additional distal pancreatectomy) or an adjustable gastric band (n = 4) around the pouch in 12 consecutive patients presenting with severe hypoglycemia (blood glucose below 2.2 mM). At follow-up after restoration of gastric restriction (median follow-up 7 months, range 5 to 19 months), 11 patients demonstrated no hypoglycemic episodes, while one had recurrence of hypoglycemia and underwent distal pancreatectomy. Procedural mortality was 0% and morbidity 8.3%., Conclusion: Patients suffering from severe recurrent hypoglycemia after GBS can be treated, in most cases, just by restoration of gastric restriction. Distal pancreatectomy should be considered a second-line treatment.

Published
2008
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23. [Microbial dispersion during high speed instrumentation].

Author

Neder AC, Biral RR, Sahade W, Vaz de Arruda J, Ranali J, and de Matos Filho TR

Subjects
Air Pollutants, Occupational, Dental Cavity Preparation instrumentation, Humans, Air Microbiology, Dental High-Speed Equipment adverse effects
Published
1980

28. [Efficacy of antisepsis in intraoral anesthesia].

Author

Biral RR, Ranali J, Sahade W, Vaz de Arruda J, and Neder AC

Subjects
Humans, Anesthesia, Local, Anti-Infective Agents, Local pharmacology, Antisepsis methods, Asepsis methods, Mouth Mucosa microbiology
Published
1979

29. Antimicrobial effects of endodontic filling cements on microorganisms from root canal.

Author

Pupo J, Biral RR, Benatti O, Abe A, and Valdrighi L

Subjects
Anti-Infective Agents, Local, Anti-Inflammatory Agents pharmacology, Balsams pharmacology, Barium Sulfate pharmacology, Bismuth pharmacology, Borates pharmacology, Condiments, Dexamethasone pharmacology, Drug Combinations pharmacology, Eugenol pharmacology, Formaldehyde pharmacology, Methenamine pharmacology, Polyvinyls pharmacology, Resins, Plant pharmacology, Resins, Synthetic pharmacology, Silver pharmacology, Thymol analogs & derivatives, Thymol pharmacology, Time Factors, Titanium pharmacology, Zinc Oxide pharmacology, Administration, Topical, Bacteria drug effects, Dental Pulp Cavity microbiology, Epoxy Resins, Hydrocortisone, Root Canal Filling Materials pharmacology
Published
1983
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30. [Evaluation of a new dental antiseptic].

Author

Neder AC, Ranali J, de Arruda JV, Biral RR, and de Mattos Filho TR

Subjects
Gingivitis prevention & control, Humans, Chlorhexidine pharmacology, Dental Plaque prevention & control
Published
1977

32. A histological study of the effect of diameter enlargement of the apical portion of the root canal.

Author

Benatti O, Valdrighi L, Biral RR, and Pupo J

Subjects
Animals, Connective Tissue anatomy & histology, Connective Tissue physiology, Dogs, Periapical Tissue anatomy & histology, Periapical Tissue physiology, Periodontal Ligament anatomy & histology, Wound Healing, Dental Pulp Cavity anatomy & histology, Periodontal Ligament physiology, Root Canal Therapy, Tooth Root anatomy & histology
Published
1985
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33. [The acidity of silicate cements].

Author

Stolf WL, Consani S, Biral RR, and Ruhnke LA

Subjects
Dental Cements, Hydrogen-Ion Concentration, In Vitro Techniques, Silicate Cement
Published
1975

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