11 results on '"Bharambe V"'
Search Results
2. Microglial profile in human Alzheimerʼs disease following active Aβ42 immunization: O24
- Author
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Zotova, E., Bharambe, V., Holmes, C., Neal, J. W., Love, S., Nicoll, J. A.R., and Boche, D.
- Published
- 2012
3. Epidemiological and cohort study finds no association between COVID-19 and Guillain-Barré syndrome
- Author
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Keddie, S, primary, Pakpoor, J, additional, Mousele, C, additional, Pipis, M, additional, Machado, PM, additional, Foster, M, additional, Record, CJ, additional, Keh, YS, additional, Fehmi, J, additional, Paterson, RW, additional, Bharambe, V, additional, Clayton, LM, additional, Allen, C, additional, Price, O, additional, Wall, J, additional, Kiss-Csenki, A, additional, Rathnasabapathi, DP, additional, Geraldes, R, additional, Yermakova, T, additional, King-Robson, J, additional, Zosmer, M, additional, Rajakulendran, S, additional, Nortley, R, additional, Marshall, CR, additional, Newman, E, additional, Nirmalananthan, N, additional, Kumar, G, additional, Pinto, AA, additional, Holt, J, additional, Lavin, TM, additional, Brennan, K, additional, Zandi, M, additional, Jayaseelan, DL, additional, Pritchard, J, additional, Hadden, RDM, additional, Manji, H, additional, Willison, HJ, additional, Rinaldi, S, additional, Carr, AS, additional, and Lunn, MP, additional
- Published
- 2020
- Full Text
- View/download PDF
4. Clinical perspectives into the use of thalidomide for central nervous system tuberculosis
- Author
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Keddie, S., primary, Bharambe, V., additional, Jayakumar, A., additional, Shah, A., additional, Sanchez, V., additional, Adams, A., additional, and Gnanapavan, S., additional
- Published
- 2018
- Full Text
- View/download PDF
5. Study of annular pancreas – A rare finding
- Author
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Kanasker, Neelesh, primary and Bharambe, V., additional
- Published
- 2016
- Full Text
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6. The global brain health clinical exchange platform: Translating concepts to collaborations.
- Author
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Wood GK, Thakur KT, Bharambe V, Chomba M, García-Azorín D, Prasad K, Souza MNP, Chou SH, Giraldo JDR, Fink E, Hoo FK, Siddiqi OK, Solomon T, Winkler AS, and Michael BD
- Subjects
- Humans, International Cooperation, Brain diagnostic imaging, Global Health, Neurology
- Published
- 2022
- Full Text
- View/download PDF
7. Epidemiological and cohort study finds no association between COVID-19 and Guillain-Barré syndrome.
- Author
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Keddie S, Pakpoor J, Mousele C, Pipis M, Machado PM, Foster M, Record CJ, Keh RYS, Fehmi J, Paterson RW, Bharambe V, Clayton LM, Allen C, Price O, Wall J, Kiss-Csenki A, Rathnasabapathi DP, Geraldes R, Yermakova T, King-Robson J, Zosmer M, Rajakulendran S, Sumaria S, Farmer SF, Nortley R, Marshall CR, Newman EJ, Nirmalananthan N, Kumar G, Pinto AA, Holt J, Lavin TM, Brennan KM, Zandi MS, Jayaseelan DL, Pritchard J, Hadden RDM, Manji H, Willison HJ, Rinaldi S, Carr AS, and Lunn MP
- Subjects
- Adult, Aged, Aged, 80 and over, Cohort Studies, Female, Humans, Male, Middle Aged, Prospective Studies, Retrospective Studies, SARS-CoV-2, United Kingdom epidemiology, Young Adult, COVID-19 epidemiology, Guillain-Barre Syndrome epidemiology
- Abstract
Reports of Guillain-Barré syndrome (GBS) have emerged during the Coronavirus disease 2019 (COVID-19) pandemic. This epidemiological and cohort study sought to investigate any causative association between COVID-19 infection and GBS. The epidemiology of GBS cases reported to the UK National Immunoglobulin Database was studied from 2016 to 2019 and compared to cases reported during the COVID-19 pandemic. Data were stratified by hospital trust and region, with numbers of reported cases per month. UK population data for COVID-19 infection were collated from UK public health bodies. In parallel, but separately, members of the British Peripheral Nerve Society prospectively reported incident cases of GBS during the pandemic at their hospitals to a central register. The clinical features, investigation findings and outcomes of COVID-19 (definite or probable) and non-COVID-19 associated GBS cases in this cohort were compared. The incidence of GBS treated in UK hospitals from 2016 to 2019 was 1.65-1.88 per 100 000 individuals per year. GBS incidence fell between March and May 2020 compared to the same months of 2016-19. GBS and COVID-19 incidences during the pandemic also varied between regions and did not correlate with one another (r = 0.06, 95% confidence interval: -0.56 to 0.63, P = 0.86). In the independent cohort study, 47 GBS cases were reported (COVID-19 status: 13 definite, 12 probable, 22 non-COVID-19). There were no significant differences in the pattern of weakness, time to nadir, neurophysiology, CSF findings or outcome between these groups. Intubation was more frequent in the COVID-19 affected cohort (7/13, 54% versus 5/22, 23% in COVID-19-negative) attributed to COVID-19 pulmonary involvement. Although it is not possible to entirely rule out the possibility of a link, this study finds no epidemiological or phenotypic clues of SARS-CoV-2 being causative of GBS. GBS incidence has fallen during the pandemic, which may be the influence of lockdown measures reducing transmission of GBS inducing pathogens such as Campylobacter jejuni and respiratory viruses., (© Crown copyright 2020.)
- Published
- 2021
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- View/download PDF
8. Herpes simplex virus encephalitis in a patient receiving ustekinumab associated with extensive cerebral oedema and brainshift successfully treated by immunosuppression with dexamethasone.
- Author
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Van Den Tooren HK, Bharambe V, Silver N, and Michael BD
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- Acyclovir administration & dosage, Acyclovir therapeutic use, Adult, Anti-Inflammatory Agents administration & dosage, Antiviral Agents administration & dosage, Antiviral Agents therapeutic use, Brain Edema chemically induced, Brain Edema diagnostic imaging, Brain Edema drug therapy, Dexamethasone administration & dosage, Dexamethasone therapeutic use, Diagnosis, Differential, Encephalitis, Herpes Simplex cerebrospinal fluid, Encephalitis, Herpes Simplex chemically induced, Encephalitis, Herpes Simplex drug therapy, Humans, Male, Psoriasis drug therapy, Anti-Inflammatory Agents therapeutic use, Brain Edema diagnosis, Dermatologic Agents adverse effects, Encephalitis, Herpes Simplex diagnosis, Immunocompromised Host, Ustekinumab adverse effects
- Abstract
Herpes simplex virus (HSV) encephalitis affects 2-4 people per million/year. Immunocompomised patients can have atypical presentations of HSV encephalitis, including a lack of cerebrospinal fluid (CSF) pleocytosis. We present the case of a patient who was receiving ustekinumab therapy for psoriasis which inhibits interleukin (IL)-12 and IL-23 signalling pathways. The initial presentation was suggestive of encephalitis, but he was discharged prior to the reporting of HSV positivity due to the lack of CSF pleocytosis. On representation, he had worsening symptoms and imaging showed midline shift, indicating cerebral oedema despite the immunosupressant effects of ustekinumab. He required intensive care unit support and treatment with high dose aciclovir and dexamethasone; after a month of treatment he made a good recovery. This case is the first to report a link between ustekinumab and HSV encephalitis, and also emphasises that imunocompromised patients can lack CSF pleocytosis and develop significant cerebral oedema which responds to immune suppression., Competing Interests: Competing interests: BDM reports grants from National Institute of Heath Research, grants from Welcome Trust, grants from Academy of Medical Sciences, grants from British Medical Association, grants from British Infection Association, outside the submitted work. NS reports personal fees from Novatis, personal fees from Eli Lilly, personal fees from Teva, personal fees from Allergan, personal fees from Electrocore, outside the submitted work., (© BMJ Publishing Group Limited 2019. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2019
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9. Functional cognitive disorders: demographic and clinical features contribute to a positive diagnosis.
- Author
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Bharambe V and Larner AJ
- Subjects
- Adult, Age Factors, Aged, Aged, 80 and over, Cognition Disorders physiopathology, Cohort Studies, Cross-Sectional Studies, Dementia diagnosis, Dementia epidemiology, Dementia physiopathology, Female, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Young Adult, Cognition Disorders diagnosis, Cognition Disorders epidemiology
- Abstract
Aim: To examine features associated with functional cognitive disorders (FCDs) compared with neurological cognitive disorders (dementia, mild cognitive impairment, transient amnesias) in consecutive patients referred to a secondary care cognitive disorders clinic., Methods: Patients diagnosed with either neurological cognitive disorder or FCD were compared by demographic (age, gender, handedness, referral source) and clinical features (family history of dementia, clinical signs, Likert screening measure of subjective memory complaint, mini-Addenbrooke's Cognitive Examination)., Results: Patients diagnosed with FCD were younger than those with neurological cognitive disorders, and more likely to attend alone, have a family history of dementia and be categorized as positive for subjective memory complaint., Conclusion: These data suggest features which may be helpful in making a positive diagnosis of FCD and differentiating from neurological cognitive disorders.
- Published
- 2018
- Full Text
- View/download PDF
10. Mechanochromic Stretchable Electronics.
- Author
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Barbee MH, Mondal K, Deng JZ, Bharambe V, Neumann TV, Adams JJ, Boechler N, Dickey MD, and Craig SL
- Abstract
Soft and stretchable electronics are promising for a variety of applications such as wearable electronics, human-machine interfaces, and soft robotics. These devices, which are often encased in elastomeric materials, maintain or adjust their functionality during deformation, but can fail catastrophically if extended too far. Here, we report new functional composites in which stretchable electronic properties are coupled to molecular mechanochromic function, enabling at-a-glance visual cues that inform user control. These properties are realized by covalently incorporating a spiropyran mechanophore within poly(dimethylsiloxane) to indicate with a visible color change that a strain threshold has been reached. The resulting colorimetric elastomers can be molded and patterned so that, for example, the word "STOP" appears when a critical strain is reached, indicating to the user that further strain risks device failure. We also show that the strain at color onset can be controlled by layering silicones with different moduli into a composite. As a demonstration, we show how color onset can be tailored to indicate a when a specified frequency of a stretchable liquid metal antenna has been reached. The multiscale combination of mechanochromism and soft electronics offers a new avenue to empower user control of strain-dependent properties for future stretchable devices.
- Published
- 2018
- Full Text
- View/download PDF
11. Inflammatory components in human Alzheimer's disease and after active amyloid-β42 immunization.
- Author
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Zotova E, Bharambe V, Cheaveau M, Morgan W, Holmes C, Harris S, Neal JW, Love S, Nicoll JA, and Boche D
- Subjects
- Aged, Aged, 80 and over, Alzheimer Disease metabolism, Antigens, CD metabolism, Calcium-Binding Proteins, Complement C1q metabolism, DNA-Binding Proteins metabolism, Female, Follow-Up Studies, Humans, Immunoglobulin G metabolism, Male, Microfilament Proteins, Middle Aged, Receptors, Scavenger metabolism, Statistics, Nonparametric, tau Proteins metabolism, Alzheimer Disease immunology, Alzheimer Disease therapy, Amyloid beta-Peptides immunology, Peptide Fragments immunology, Vaccination methods
- Abstract
Inflammatory processes are important in the pathogenesis of Alzheimer's disease and in response to amyloid-β immunotherapy. We investigated the expression of multiple inflammatory markers in the brains of 28 non-immunized patients with Alzheimer's disease and 11 patients with Alzheimer's disease immunized against amyloid-β42 (AN1792): microglial ionized calcium-binding adaptor Iba-1, lysosome marker CD68, macrophage scavenger receptor A, Fcγ receptors I (CD64) and II (CD32); and also immunoglobulin IgG, complement C1q and the T lymphocyte marker CD3 using immunohistochemistry. The data were analysed with regard to amyloid-β and phospho-tau pathology, severity of cerebral amyloid angiopathy and cortical microhaemorrhages. In non-immunized Alzheimer's disease cases, amyloid-β42 correlated inversely with CD32 and Iba-1, whereas phospho-tau correlated directly with all microglial markers, IgG, C1q and the number of T cells. In immunized Alzheimer's disease cases, amyloid-β42 load correlated directly with macrophage scavenger receptor A-positive clusters and inversely with C1q. The severity of cerebral amyloid angiopathy and microhaemorrhages did not relate to any of the analysed markers. Overall, the levels of CD68, macrophage scavenger receptor A, CD64, CD32 and the number of macrophage scavenger receptor A-positive plaque-related clusters were significantly lower in immunized than non-immunized cases, although there was no significant difference in Iba-1 load, number of Iba-1-positive cells, IgG load, C1q load or number of T cells. Our findings indicate that different microglial populations co-exist in the Alzheimer's disease brain, and that the local inflammatory status within the grey matter is importantly linked with tau pathology. After amyloid-β immunization, the microglial functional state is altered in association with reduced amyloid-β and tau pathology. The results suggest that, in the long term, amyloid-β immunotherapy results in downregulation of microglial activation and potentially reduces the inflammation-mediated component of the neurodegeneration of Alzheimer's disease.
- Published
- 2013
- Full Text
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