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Herpes simplex virus encephalitis in a patient receiving ustekinumab associated with extensive cerebral oedema and brainshift successfully treated by immunosuppression with dexamethasone.
- Source :
-
BMJ case reports [BMJ Case Rep] 2019 Aug 13; Vol. 12 (8). Date of Electronic Publication: 2019 Aug 13. - Publication Year :
- 2019
-
Abstract
- Herpes simplex virus (HSV) encephalitis affects 2-4 people per million/year. Immunocompomised patients can have atypical presentations of HSV encephalitis, including a lack of cerebrospinal fluid (CSF) pleocytosis. We present the case of a patient who was receiving ustekinumab therapy for psoriasis which inhibits interleukin (IL)-12 and IL-23 signalling pathways. The initial presentation was suggestive of encephalitis, but he was discharged prior to the reporting of HSV positivity due to the lack of CSF pleocytosis. On representation, he had worsening symptoms and imaging showed midline shift, indicating cerebral oedema despite the immunosupressant effects of ustekinumab. He required intensive care unit support and treatment with high dose aciclovir and dexamethasone; after a month of treatment he made a good recovery. This case is the first to report a link between ustekinumab and HSV encephalitis, and also emphasises that imunocompromised patients can lack CSF pleocytosis and develop significant cerebral oedema which responds to immune suppression.<br />Competing Interests: Competing interests: BDM reports grants from National Institute of Heath Research, grants from Welcome Trust, grants from Academy of Medical Sciences, grants from British Medical Association, grants from British Infection Association, outside the submitted work. NS reports personal fees from Novatis, personal fees from Eli Lilly, personal fees from Teva, personal fees from Allergan, personal fees from Electrocore, outside the submitted work.<br /> (© BMJ Publishing Group Limited 2019. No commercial re-use. See rights and permissions. Published by BMJ.)
- Subjects :
- Acyclovir administration & dosage
Acyclovir therapeutic use
Adult
Anti-Inflammatory Agents administration & dosage
Antiviral Agents administration & dosage
Antiviral Agents therapeutic use
Brain Edema chemically induced
Brain Edema diagnostic imaging
Brain Edema drug therapy
Dexamethasone administration & dosage
Dexamethasone therapeutic use
Diagnosis, Differential
Encephalitis, Herpes Simplex cerebrospinal fluid
Encephalitis, Herpes Simplex chemically induced
Encephalitis, Herpes Simplex drug therapy
Humans
Male
Psoriasis drug therapy
Anti-Inflammatory Agents therapeutic use
Brain Edema diagnosis
Dermatologic Agents adverse effects
Encephalitis, Herpes Simplex diagnosis
Immunocompromised Host
Ustekinumab adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1757-790X
- Volume :
- 12
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- BMJ case reports
- Publication Type :
- Academic Journal
- Accession number :
- 31413050
- Full Text :
- https://doi.org/10.1136/bcr-2019-229468