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1. The Association between Blood Pressure and Clinical Outcomes in Patients Undergoing Transcatheter Aortic Valve Implantation

Author

Idan Goldberg, Uri Landes, Genady Drozdinsky, Pablo Codner, Tamir Bental, Katia Orvin, Nili Schamroth Pravda, Lotem Goldberg, Omri Soudry, Tsahi T. Lerman, Ran Kornowski, Alon Eisen, and Hana Vaknin-Assa

Subjects
transcatheter aortic valve implantation, systolic blood pressure, pulse pressure, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Introduction: Transcatheter aortic valve implantation (TAVI) has emerged as a common and effective treatment for patients with severe aortic stenosis. Changes in systemic blood pressure after TAVI have been described, yet their prognostic value is not established. Thus, we aimed to examine the association of the periprocedural changes in systolic blood pressure (SBP) and in pulse pressure on clinical outcomes after the procedure. Methods: A retrospective study of consecutive patients who underwent TAVI procedure in our medical center. We assessed the effect of the periprocedural changes in blood pressure measurements on mortality, acute myocardial infarction, stroke and hospitalizations at 1 year and on the combined outcome of death, myocardial infarction, and stroke 1 year following the procedure. Results: Our cohort included 455 patients (44% males). Of them, 343 patients (75.4%) had raised SBP immediately after the procedure. Patients with raised SBP had a significantly higher rate of the 1-year composite outcome, compared to patients who did not have a raise in SBP following the procedure (43 [13%] vs. 6 [5.4%], respectively, p = 0.033). After adjustment for age and sex, the postprocedural increase in SBP was significantly associated with the composite outcome, with a hazard ratio of 2.42, 95% CI: 1.03–5.7. Conclusion: An immediate increase in SBP after TAVI is associated with worse 1-year clinical cardiovascular outcomes.

Published
2024
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2. Incidence, prevalence and clinical presentation of inflammatory bowel diseases in Northern France: a 30-year population-based studyResearch in context

Author

Hélène Sarter, Thibaut Crétin, Guillaume Savoye, Mathurin Fumery, Ariane Leroyer, Luc Dauchet, Thierry Paupard, Hugues Coevoet, Pauline Wils, Nicolas Richard, Dominique Turck, Delphine Ley, Corinne Gower-Rousseau, Eric Agoute, Najib Al Ghossaini, Raied Al Hameedi, Myriam Al Khatib, Saria Al Turk, Jean-Marie Andre, Matthieu Antoine, Michel Antonietti, Amar Aouakli, Laura Armengol-Debeir, Ibrahim Aroichane, Fadi Assi, Eric Auxenfants, Alina Avram, Kassem Azzouzi, Damyan Bankovski, Bernard Barbry, Nicolas Bardoux, Philippe Baron, Anne Baudet, Pauline Bayart, Brice Bazin, Arash Bebahani, Jean-Pierre Becqwort, Houssem Ben Ali, Emmanuel Ben Soussan, Coralie Benard, Vincent Benet, Corinne Benguigui, Abdeslam Bental, Sara Bentaleb-Bellati, Isabelle Berkelmans, Jacques Bernet, Karine Bernou, Nathalie Bertiaux-Vandaele, Pauline Bertot, Valérie Bertrand, Emilie Biloud, Nathalie Biron, Benjamin Bismuth, Cyril Blanchard, Maurice Bleuez, Fabienne Blondel, Valérie Blondin, Marius Bobula, Philippe Bohont, Eléonore Boivin, Vanessa Bon Djemah, Eric Boniface, Philippe Bonniere, Pierre Bonvarlet, Arnaud Boruchowicz, Raoul Bostvironnois, Médina Boualit, Ahlem Bouazza, Bruno Bouche, Christian Boudailler, Claude Bourgeaux, Morgane Bourgeois-Fumery, Arnaud Bourguet, Agnès Bourienne, Hamza Boutaleb, Alexis Bouthors, Julien Branche, Franck Brazier, Marie Bridenne, Hélène Brihier, Laura Bril, Philippe Bulois, Pierre Burgiere, Joël Butel, Jean-Yves Canva, Valérie Canva-Delcambre, Florence Cardot, Sandrine Carette, Pierre Carpentier, Michel Cassagnou, Jean-François Cassar, François Castex, Pascale Catala, Stéphane Cattan, Sylviane Catteau, Bernard Caujolle, Gérard Cayron, Catherine Chandelier, Cloé Charpentier, Marthe Chavance-Thelu, Agathe Cheny, Dinu Chirita, Antoine Choteau, Jean-François Claerbout, Pierre-Yves Clergue, Gil Cohen, Marie Colin, Régis Collet, Jean-Frédéric Colombel, Stéphanie Coopman, Lucie Cordiez, Antoine Cortot, Jean Corvisart, Frédéric Couttenier, Jean-François Crinquette, Valérie Crombe, Abdelhakim Daoudi, Vincent Dapvril, Thierry Davion, Sébastien Decoster, Laurent Defontaine, Nicolas Degrave, Aurélien Dejaeger, Richard Delcenserie, Marine Deleplanque, Dorothée Delesalle, Olivier Delette, Thierry Delgrange, Laurence Delhoustal, Jean-Stéphane Delmotte, Sabri Demmane, Guy Deregnaucourt, Constance Deschepper, Jean-Pierre Desechalliers, Patrick Desmet, Pierre Desreumaux, Gérard Desseaux, Philippe Desurmont, Alain Devienne, Eve Devouge, Alex Devroux, Arnaud Dewailly, Sébastien Dharancy, Aude Di Fiore, Emmanuel Diaz, Djamal-Dine Djeddi, Rachid Djedir, Wissam Doleh, Marie-Laure Dreher-Duwat, Richard Dubois, Clothilde Duburque, Frédéric Ducrot, Philippe Ducrotte, André Dufilho, Christian Duhamel, Caroline Dumant-Forest, Jean-Louis Dupas, Frédéric Dupont, Yves Duranton, Arnaud Duriez, Nicolas Duveau, Mohammadi El Farisi, Khalil El Hachkar, Caroline Elie, Marie-Claire Elie-Legrand, Matthieu Eoche, Essmaeel Essmaeel, Dominique Evrard, Jean-Paul Evrard, Armelle Fatome, Karima Fellah-Sekkai, Bernard Filoche, Laurent Finet, Mathilde Flahaut, Camille Flamme, David Foissey, Peggy Fournier, Philippe Foutrein, Marie-Christine Foutrein-Comes, Thierry Frere, Julie Galand, Philippe Gallais, Claudine Gamblin, Serge Ganga, Romain Gerard, Guillaume Geslin, Yves Gheyssens, Salah Ghrib, Thierry Gilbert, Bénédicte Gillet, Denis Godart, Jean-Michel Godchaux, Guetty Goeguebeur, Odile Goria, Frédéric Gottrand, Philippe Gower, Lucien Grados, Brigitte Grandmaison, Marion Groux, Claire Guedon, Loïc Guerbeau, Mathilde Gueroult-Dero, Jean-François Guillard, Laurence Guillem, François Guillemot, Dominique Guimber, Baya Haddouche, Vincent Hautefeuille, Philippe Hecketsweiller, Geneviève Hecquet, Jean-Pierre Hedde, Hassina Hellal, Pierre-Emmanuel Henneresse, Michel Heraud, Sophie Herve, Bruno Heyman, Patrick Hochain, Philippe Houcke, Lucie Houssin-Baillly, Bruno Huguenin, Silviu Iobagiu, Shata Istanboli, Alexsandar Ivanovic, Isabelle Iwanicki-Caron, Eric Janicki, Marine Jarry, Charlotte Jean Bart, Claude Jonas, Julia Jougon, Anne Jouvenet, Naeim Kassar, Fadi Katherin, Alfred Kerleveo, Ali Khachfe, Alfred Kiriakos, Jean Kiriakos, Olivier Klein, Matthieu Kohut, Richard Kornhauser, Demetrios Koutsomanis, Jean-Eric Laberenne, Eric Lacotte, Guy Laffineur, Marine Lagarde, Anouck Lahaye, Arnaud Lalanne, Ambroise Lalieu, Pierre Lannoy, José Lapchin, Michel Laprand, Denis Laude, Christian Le Couteulx, Charles Le Goffic, Alain Le Grix, Jean-Philippe Le Mouel, Pauline Le Roy, Rachida Leblanc, Paul Lecieux, Stéphane Lecleire, Nathalie Leclerc, Jean Ledent, Jean Lefebvre, Pascale Lefilliatre, Céline Legrand, Patrick Lelong, Bernard Leluyer, Caroline Lemaitre, Lucie Lepileur, Antoine Leplat, Elodie Lepoutre-Dujardin, Gabriel Leppeut, Henri Leroi, Maryvonne Leroy, Benoît Lesage, Jocelyn Lesage, Xavier Lesage, Isabelle Lescanne-Darchis, Dominique Lescut, Bruno Leurent, Michel Lhermie, Louise Libier, Bernard Lisambert, Isabelle Loge, Julien Loreau, Alexandre Louvet, Joséphine Lozinguez, Henri Lubrez, Damien Lucidarme, Jean-Jacques Lugand, Olivier Macaigne, Denis Maetz, Dominique Maillard, Hubert Mancheron, Olivia Manolache, Anne-Bérengère Marks-Brunel, Charline Marre, Raymond Marti, Eric Marzloff, Philippe Mathurin, Jacques Mauillon, Vincent Maunoury, Jean-Luc Maupas, Michèle-Ange Medam Djomo, Chloé Melchior, Ziad Melki, B. Mesnard, Patrice Metayer, Lofti Methari, Franck Meurisse, Laurent Michaud, Patricia Modaine, Angélique Monthe, Loïk Morel, Mathilde Morin, Pierre-Eugène Mortier, Perrine Mortreux, Olivier Mouterde, Nicolas Mozziconaci, Jean Mudry, Maria Nachuri, Minh Dung Ngo, Eric N'guyen Khac, Bertrand Notteghem, Vincent Ollevier, Atika Ouraghi, Barriza Oussadou, Dominique Ouvry, Bernard Paillot, Claire Painchart, Nicole Panien-Claudot, Christian Paoletti, Arsène Papazian, Bruno Parent, Jean-Claude Paris, Philippe Patrier, Bernard Pauwels, Mathieu Pauwels, Richard Petit, Muriel Piat, Sandrine Piotte, Christophe Plane, Bernard Plouvier, Eric Pollet, Pierre Pommelet, Daniela Pop, Charlotte Pordes, Gérard Pouchain, Philippe Prades, Jean-Christophe Prevost, Manon Pruit, Gilles Quartier, Anne-Marie Queuniet, Jean-François Quinton, Alain Rabache, Gilles Raclot, Sébastien Ratajczyk, Nicole Reix, Thibaud Renaut-Vantroys, Marine Revillion, Ghassan Riachi, Clémentine Riault, Cécile Richez, Benoît Rimbert, Philippe Robinson, Juan Daniel Rodriguez, Jean Roger, Jean-Marc Roux, Alain Rudelli, Clémence Saingier, Patrick Schlossberg, David Sefrioui, Michel Segrestin, David Seguy, Célik Seminur, François Sevenet, Jean Silvie, Claire Spyckerelle, Nathalie Talbodec, Noémie Tavernier, Henriette Tchandeu, Aurore Techy, Jean-Luc Thelu, Henri Thiebault, Jean-Marie Thorel, Christophe Thuillier, Guillaume Tielman, Manuella Tode, Jean Tonnel, Jean-Yves Touchais, Audrey Toulemonde-Huguet, Pierre Toumelin, Yvan Touze, Léa Tran, Jean-Luc Tranvouez, Nadia Triki, Justine Turpin, Eric Vaillant, Claude Valmage, Dominique Vanco, Nathalie Vandaele-Bertiaux, Hélène Vandamme, Elise Vander Eeken, Etienne Vanderbercq, Philippe Vandermollen, Philippe Vandevenne, Lionel Vandeville, Alain Vandewalle, Jean-Pierre Vanhoove, Audrey Vanrenterghem, Charlotte Vanveuren, Iona Vasies, Guy Verbiese, Juliette Verlynde, Philippe Vermelle, Christine Verne, Gwenola Vernier-Massouille, Perrine Vezelier-Cocq, Juliette Viart, Benoît Vigneron, Marc Vincendet, Jacques Viot, Y.M. Voiment, Jean-Yves Wallez, Michel Wantier, Faustine Wartel, Jean-Christian Weber, Jean-Louis Willocquet, Nathalie Wizla, Eric Wolschies, Tajiogue Yimfor, Oana Zahara, Alberto Zalar, Sonia Zaoui, and Anne Zellweger

Subjects
Inflammatory bowel disease, Incidence, Prevalence, Population-based registry, Crohn’s disease, Ulcerative colitis, Public aspects of medicine, RA1-1270
Abstract

Summary: Background: In industrialized countries, the incidence of inflammatory bowel disease (IBD) appears stabilized. This study examined the incidence and phenotype of IBD in Northern France over a 30-year period. Methods: Including all IBD patients recorded in the EPIMAD population-based registry from 1988 to 2017 in Northern France, we described the incidence and clinical presentation of IBD according to age, sex and time. Findings: A total of 22,879 incident IBD cases were documented (59% (n = 13,445) of Crohn’s disease (CD), 38% (n = 8803) of ulcerative colitis (UC), 3% (n = 631) of IBD unclassified (IBDU)). Over the study period, incidence of IBD, CD and UC was 12.7, 7.2 and 5.1 per 105 person-years, respectively. The incidence of CD increased from 5.1/105 in 1988–1990 to 7.9/105 in 2015–2017 (annual percent change (APC): +1.9%, p

Published
2024
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4. Listeria monocytogenes-associated spontaneous bacterial peritonitis in France: a nationwide observational study of 208 cases

Author

Abdou, Mohamed, Abdulhai, Ayman, Abdulhal, Ayman, Abel, Samy, Abergel, Armand, Aberrane, Saïd, Abraham, Bruno, Adler, Maxime, Agard, Christian, Agha-Mir, Ilhem, Aguilar, Claire, Agulles, Baptiste, Aldallal, Hamza, Alric, Laurent, Amiot, Xavier, Andrau, Pierre, Andrieux, Vladimir, Ansart, Séverine, Anty, Rodolphe, Archambeaud, Isabelle, Arem, Samir, Armand, Laurence, Aubailly, Lucie, Audibert, Juliette, Auguereau, Olivier, Auvray, Christelle, Aziz, Karime, Bachelier, Marie-Nadège, Bacquaert-Dufour, Karine, Badet, Françoise, Bahallah, Mohamed-Larbi, Balanant, Hélène, Baraduc, Régine, Bardis, Alexandre, Barraud, Olivier, Barrier, Jocelyn, Baudet, Antoine, Baumert, Thomas, Beaugerie, Laurent, Bébéar, Cécile, Becheur, Hakim, Bemer, Pascale, Benard, Caroline, Benezet, Marie-Pierre, Benmahammed, Mohammed, Bennouna, Jaafar, Benseddik, Zehaira, Bensimon, Pierre-Yves, Bental, Abdeslam, Berete, Aliou, Bergier, Jean-Michel, Berkani, Wacila, Bernardi, Franck, Bert, Frederic, Bertrou, Anne, Beuret, Pascal, Beurton-Chataigner, Isabelle, Beuscart, Claude, Beusnel, Christine, Bevilacqua, Sibylle, Beze, François, Bideau, Karine, Bidegain, Frédéric, Billon, Laura, Blaison, Gilles, Blanc, Michèle, Blanc, Pierre, Blanchi, Sophie, Blancho, Gilles, Bland, Stephane, Blondeau, Vincent, Boldron, Amale, Bon, Djemah, Bonacorsi, Stéphane, Bonzon, Lucas, Borderon, Anaïs, Botelho-Nevers, Elisabeth, Bottlaender, Jacques, Bouc-Boucher, Mathilde, Bouchaud, Olivier, Bougon, David, Boukelikha, Khaled, Bourlet, Thomas, Boussoukaya, Samy, Boutaleb, Hamza, Bouziges, Nicole, Bray, Philippe, Bréchet, Caroline, Bret, Laurent, Brieu, Nathalie, Briffaut, David, Brochet, Christine, Brulez-Des-Varannes, Stanislas, Brunel, Valéry, Brung-Lefebvre, Maud, Bureau, Christophe, Burucoa, Christophe, Buscail, Louis, Buzele, Rodolphe, Cadot, Catherine, Cadranel, Jean-Francois, Cady, Anne, Caillon, Jocelyne, Camiade, Sabine, Campillo, Bernard, Carbonnel, Franck, Carbonnelle, Etienne, Cardot-Martin, Émilie, Cariou, Marie-Estelle, Carles, Michel, Caron, Francois, Carrara-Delarue, Lucrecia, Carrier, Paul, Castang, Céline, Castellano, Inès, Cattoir, Vincent, Caubet, Olivier, Causse, Xavier, Chabrol, Amélie, Chanard, Emmanuel, Chatagnon, Thomas, Chazouilleres, Olivier, Chedanni, Halima, Chevrel, Pauline, Chirol, Catherine, Chirouze, Catherine, Chouquer, Renaud, Clavière, Christophe, Codreuil, Sylvain, Colardelle, Philippe, Combarnous, François, Commeau, Grégory, Cornillet, Anne, Corvec, Stephane, Costa, Yannick, Couderc, Philippe, Couffon, Caroline, Courivaud, Cécile, Courtade, Henri, Cruchant, Etienne, Cuen, David, Culard, Jean-François, Cung, Hong Ahn, Dahyot, Sandrine, D'Altéroche, Louis, Dao, Manh Thông, Darfeuil, Fabien, Darnaud, Céline, Daure, Sophie, De Grossouvre-Taillefer, Ludivine, Debriel, Dominique, Debrueres, Jacques, Decaens, Thomas, Decambron, Audrey, Decre-Grapinet, Dominique, Degand, Nicolas, Dehaye, Bruno, Delacour, Thierry, Delarbe, Jean-Marie, Delobel, Pierre, Delpierre, Éric, Delrez, René, Delvert, Didier, Demartino, Sylvie, Deniel, Marie-Clémence, Denis, Bernard, Derumeaux, Guy, Desroches, Marine, Dessein, Rodrigue, Devillez, Simon, Deweerdt, Didier, Diamantis, Sylvain, Diaz, Emmanuel, Didier, Raffenot, Dimartino, Vincent, Dion, Ludivine, Djemai, Mohand, Doche, Christophe, Donascimento, Maud, Dorval, Ian, Douala, Carol, Doucet-Populaire, Florence, Drouillat, Valérie, Dubée, Vincent, Dudermel, Anne-France, Dumont, Betty, Dupin, Clarisse, Dupont, Mathieu, Dupont, Philippe, Dupuy, Marion, Dupuychaffray, Jean-Pierre, Durand, Francois, Dusser, Pascale, Duval, Valérie, Duveau, Nicolas, El-Azouzi, Abdelghani, El-Gharras, Hynd, Elsendoorn, Antoine, Emile, Loïc, Epaulard, Olivier, Etchepare, Nicolas, Etienne, Jean-Pierre, Eveillard, Mathieu, Evers, Annie, Fach, Joelle, Faizoun, Claudia, Fangous, Marie-Sarah, Farmachidi, Jean Pierre, Fatome, Armelle, Faulques, Bernard, Faure, Karine, Felix, Charlotte, Ferec, Marc, Ferey, Janine, Ferracci, Serge, Feryn, Jean-Marc, Fesler, Pierre, Fiette, Hélène, Flevin, Emilie, Floch, Pauline, Fort, Eric, Fortineau, Nicolas, Fourcade, Jacques, Fraissinet, François, Franck, Patricia, Françoise, Thiebaut, Fratte, Serge, Galempoix, Jean-Marc, Garcera, Yves, Garcia, Anne, Garcon, Pierre, Garret, Charlotte, Gayet, Clement, Gazeau, Pierre, Gerber, Florence, Gilles, Raclot, Gillot, Jean-Michel, Goarant, Eric, Godreuil, Sylvain, Goret, Julien, Gorret, Julie, Goujard, Cecile, Goulenok, Thiphaine, Gournay, Jérôme, Gousseff, Marie, Goux, Alain, Graf, Emmanuelle, Grange, Jean-Didier, Gravet, Alain, Greder-Belan, Alix, Gronier, Olivier, Grosset, Marine, Guellouz, Sabra, Guenenna, Dalida, Guerbaa, Mohammed, Guerin, Meggie, Guerrot, Dominique, Guery, Benoit, Gugenheim, Jean, Guidet, Bertrand, Guiheneuf, Raphael, Guillet-Caruba, Christelle, Guimard, Yves, Guinard, Jérome, Guindre, Laure, Hagege, Albert, Hagege, Hervé, Haineaux, Paul-Arthur, Hamon, Rémy, Hassan, Firas, Hassine, Mélanie, Helie, Ludovic, Herber-Mayne, Anne, Hervio, Pascale, Héry-Arnaud, Geneviève, Hitoto, Hikombo, Hubsch, Théophile, Hunaut, Nicolas, Hurtova, Monika, Husson-Wetzel, Stéphanie, Hutin, Pascal, Izopet, Théo, Jacob, Jean-Louis, Jacomet, Christine, Jaffar-Bandjee, Marie-Christine, Janvier, Fréderic, Jaulhac, Benoît, Jaureguiberry, Stephane, Javaud, Nicolas, Jeannot, Katty, Joundy, Noureddine, Kacem, Moez, Karama, Rouis, Karsenti, David, Kempf, Marie, Khatibi, Sarah, Kikolski, Florence, Kittirath, Christine, Koch, Stephane, Kouatchet-Achille, Tchamba, Krummel, Yves, La Combe, Karine, Labarriere, Damien, Laberenne, Jean-Eric, Lacroix, Hervé, Ladrat, Laure, Lagarde, Stéphanie, Lagasse, Jean-Paul, Laggoune, Ahmed-Saïd, Lambare, Benedicte, Landgraf, Nathalie, Landraud, Luce, Laude, Jean-Francois, Laurent, François, Lavigne, Jean-Philippe, Lavoue, Vincent, Le Berre, Rozenn, Le Goff, Vallérie, Lebars, Hervé, Lebrun, Armandine, Lecapitaine, Anne-Lise, Lechat, Sylvie, Lecoustumier, Alain, Ledreau, Gérard, Lefevre, Benjamin, Leflon, Véronique, Lefort, Agnès, Legall, Florence, Legoff, Isabelle, Legrand, Eric, Lehello, Simon, Le-Henaff-Bourhis, Catherine, Leleu, Olivier, Lelievre, Lucie, Lemaignen, Adrien, Lemaire, Xavier, Le-Maout, Charles, Lemblé, Chantal, Lemeille, Yolande, Lemenand, Olivier, Lemeunier, Violaine, Lemeur, Yannick, Lemierre, Sylvia, Leotard, Sophie, Lepileur, Lucie, Letellier-Demonchy, Claire, Levecq, Hervé, Levy, Marc, Limal, Nicolas, Locher, Christophe, Lopez, Benjamin, Loron, Marie-Charlotte, Loulergue, Joelle, Loury-Larivière, Isabelle, Loustaud-Ratti, Véronique, Macchi, Valèrie, Machado, Moise, Madaule, Serge, Mainardi, Jean-Luc, Males, Silvija, Malherbe, Philippe, Maneglier, Benjamin, Marceau, Maryline, Marcel, Kévin, Marmonier, Alain, Martha, Benoît, Martin, Xavier, Martin-Blondel, Guillaume, Martinez, Camille, Marty, Fabrice, Marty, Patrick, Matray, Olivier, Maurin, Arnaud, Mazerand, Sandie, Mazouz, Nadia, Medevielle, Muriel, Mercat, Alain, Méreghetti, Laurent, Merzoug, Noureddine, Meziane, Ilham, Michaud, Anthony, Michel, Marc, Michel, Pierre, Mignard, Sophie, Milesi-Lecat, Anne-Marie, Mion, Mathieu, Mnasri, Nabil, Mohareb, Abdo, Mohib, Samir, Moindrot, Henri, Monlun, Eric, Montewis, Audrey, Morin, Thierry, Moussata, Driffa, Muller, Sandrine, Muzellec, Valérie, Nancey, Stéphane, Nassereddine, Ahmad, Naude, Sebastien, Neau, Didier, Ovidiu, Negru Calin, Ngo, Thuy, Ngwhotue, Marthe-Andree, Nivet, Patrick, Nordmann, Patrice, Nousbaum, Jean-Baptiste, Nouvel, Bernadette, Obled, Stephane, Oswald, Eric, Otto, Marie-Pierre, Pageaux, Georges-Philippe, Papin, Gregory, Parant, Fabrice, Patenotte, Arnaud, Paupard, Thierry, Pauwels, Arnaud, Pawlotsky, Jean Michel, Pelloux, Hervé, Perlemuter, Gabriel, Peron, Jean-Marie, Pestel-Caron, Martine, Peter, Natasha, Petillon, Sophie, Petit, Richard, Petitprez, Helene, Pettinelli, Francois, Phelip, Jean Marc, Philit, Jean-Baptiste, Phoutthasang, Valérie, Pialoux, Gilles, Piau-Couapel, Caroline, Pichard, Benoit, Pichon, Maxime, Picon-Coste, Magali, Picque, Marie, Pierson, Henri, Piques, Jean Francois, Piton, Béatrice, Planade, Orianne, Plassart, Claire, Plésiat, Patrick, Ploy, Marie-Cécile, Poubeau, Patrice, Pouderoux, Philippe, Pouedras, Pascal, Pourbaix, Annabelle, Poynard, Thierry, Preau, Florence, Pricope, Dumitrita, Queffelec, Gwenaëlle, Queneherve, Lucille, Quentin, Thomas, Raffenot, Didier, Rakotoniaina, Daniella, Ramanantsoa, Celine, Ramarijaona, Solofoniaina, Rami-Arab, Lila, Raulin, Olivia, Rebibou, Jean Michel, Renault, David, Rey, Philippe, Riche, Agnès, Rigaud, Jean Philippe, Rivière, Antoine, Rivière, Brigitte, Robert, Jérôme, Roblot, Pascal, Roger, Helene, Rolland, Christophe, Rondinaud, Emilie, Rosa-Hezode, Isabelle, Roubille, Martine, Rouquette, Olivier, Roux, Juliette, Ruimy, Raymond, Sachot-Ollivier, Sonia, Sailler, Laurent, Salamant, Sarah, Sarbu-Pop, Silvia, Sartre, Jacques, Schmitt, François, Scribe-Outtas, Myriam, Sefrioui, David, Sehouane, Rachid, Sekhri, Hacène, Serfaty, Lawrence, Sevin, Odile, Shawali, Cédric, Siladi, Souad, Silvain, Christine, Simon, Mireille, Simonet, Batiste, Sinayoko, Leila, Sirach, Estelle, Smati, Mustafa, Smets, Aurélie, Soltani, Dhaoui, Sommabere, André, Soulier-Guerin, Karine, Soulillou, Jean Paul, Soupison, Alain, Souply, Laurent, Soussy, Claude-James, Stampfli, Claire, Strullu, Bernard, Suatean, Diana, Tadjerouni, Nacer, Talarmin, Jean-Philippe, Tankovic, Jacques, Tarroun, Abdullah, Tchuenbou, Juliette, Teboul, Jean-Louis, Tedlaouti, Husni, Tellini, Charlotte, Thabut, Dominique, Thannberger, Philippe, Thiebault, Henri, Thiebaut, Françoise, Thomazeau, Joséphine, Tielman, Guillaume, Timsit, Jean-Francois, Tognon, Patrick, Tougeron, David, Toure, Fatouma, Tran, Albert, Tranvouez, Jean-Luc, Trésallet, Christophe, Trubert, Lise, Tsakiris, Laurent, Twizeyimana, Eterne, Vachee, Anne, Valade, Hélène, Valat, Isabelle, Vandendriessche, Anne, Vandermee, Nathalie, Vanheste, Marc, Varon, Emmanuelle, Vasse, Marc, Vasseur, Philippe, Vaucel, Elisabeth, Vauthier, Anne, Verdavaine-Loidreau, Delphine, Verdet, Charlotte, Verdon, Renaud, Vergnaud, Michel, Véziris, Nicolas, Vignaud, Guillaume, Viguier, Jérôme, Villemain, Marc, Villeneuve, Laurent, Vimont-Vicary, Alexandre, Vincent, Thomas, Vuillemenot, Jean-Baptiste, Walewski, Violaine, Warmoes, Elodie, Watry, Hélène, Weber, Jean-Christophe, Witz, Marie Thérèse, Woerther, Paul-Louis, Yazdanpanah, Yazdan, Zamfir, Oana, Zarka, Jonathan, Zavadil, Patrick, Zeboudj, Nabil, Zerbib, Franck, Blanchard, Florian, Henry, Benoît, Vijayaratnam, Sofieya, Canouï, Etienne, Moura, Alexandra, Thouvenot, Pierre, Bracq-Dieye, Hélène, Tessaud-Rita, Nathalie, Valès, Guillaume, Diakité, Andrée, Leclercq, Alexandre, Lecuit, Marc, and Charlier, Caroline

Published
2024
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11. Preoperative evaluation of pulmonary hypertension in lung transplant candidates: echocardiography versus right heart catheterization

Author

Tal Abu, Amos Levi, David Hasdai, Mordechai R. Kramer, Tamir Bental, Tali Bdolah-Abram, Arthur Shyovich, Abed Samara, Hana Vaknin-Assa, Leor Perl, Dror Rosengarten, Yaron Shapira, Ran Kornowski, and Keren Skalsky

Subjects
Lung transplant, Right heart catheterization, Pulmonary hypertension, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Background Right heart catheterization (RHC) and echocardiography are both routinely used for pulmonary artery systolic pressure (PASP) assessment in lung transplantation (LT) candidates, although this is not mandated by current guidelines. We aimed to explore the performance of echocardiographic PASP as an indicator of pulmonary hypertension in LT candidates, in order to assess the necessity of RHC. Methods From a retrospective registry of 393 LT candidates undergoing RHC and echocardiography during 2015–2019, patients were assessed for the presence of pulmonary hypertension (PH), defined as mean pulmonary artery pressure (mPAP) above 20 mmHg, according to two methods—echocardiography and RHC. The primary outcome was the correlation between the PASP estimated by echocardiography to that measured by RHC. Secondary outcomes were the prediction value of the echocardiographic evaluation and its accuracy. Results The mean value of PASP estimated by echocardiography was 49.5 ± 20.0 mmHg, compared to 42.5 ± 18.0 mmHg measured by RHC. The correlation between the two measurements was moderate (Pearson’s correlation: r = 0.609, p

Published
2022
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12. Listeria monocytogenes-associated spontaneous bacterial peritonitis in France: a nationwide observational study of 208 cases

Author

Blanchard, Florian, primary, Henry, Benoît, additional, Vijayaratnam, Sofieya, additional, Canouï, Etienne, additional, Moura, Alexandra, additional, Thouvenot, Pierre, additional, Bracq-Dieye, Hélène, additional, Tessaud-Rita, Nathalie, additional, Valès, Guillaume, additional, Diakité, Andrée, additional, Leclercq, Alexandre, additional, Lecuit, Marc, additional, Charlier, Caroline, additional, Abdou, Mohamed, additional, Abdulhai, Ayman, additional, Abdulhal, Ayman, additional, Abel, Samy, additional, Abergel, Armand, additional, Aberrane, Saïd, additional, Abraham, Bruno, additional, Adler, Maxime, additional, Agard, Christian, additional, Agha-Mir, Ilhem, additional, Aguilar, Claire, additional, Agulles, Baptiste, additional, Aldallal, Hamza, additional, Alric, Laurent, additional, Amiot, Xavier, additional, Andrau, Pierre, additional, Andrieux, Vladimir, additional, Ansart, Séverine, additional, Anty, Rodolphe, additional, Archambeaud, Isabelle, additional, Arem, Samir, additional, Armand, Laurence, additional, Aubailly, Lucie, additional, Audibert, Juliette, additional, Auguereau, Olivier, additional, Auvray, Christelle, additional, Aziz, Karime, additional, Bachelier, Marie-Nadège, additional, Bacquaert-Dufour, Karine, additional, Badet, Françoise, additional, Bahallah, Mohamed-Larbi, additional, Balanant, Hélène, additional, Baraduc, Régine, additional, Bardis, Alexandre, additional, Barraud, Olivier, additional, Barrier, Jocelyn, additional, Baudet, Antoine, additional, Baumert, Thomas, additional, Beaugerie, Laurent, additional, Bébéar, Cécile, additional, Becheur, Hakim, additional, Bemer, Pascale, additional, Benard, Caroline, additional, Benezet, Marie-Pierre, additional, Benmahammed, Mohammed, additional, Bennouna, Jaafar, additional, Benseddik, Zehaira, additional, Bensimon, Pierre-Yves, additional, Bental, Abdeslam, additional, Berete, Aliou, additional, Bergier, Jean-Michel, additional, Berkani, Wacila, additional, Bernardi, Franck, additional, Bert, Frederic, additional, Bertrou, Anne, additional, Beuret, Pascal, additional, Beurton-Chataigner, Isabelle, additional, Beuscart, Claude, additional, Beusnel, Christine, additional, Bevilacqua, Sibylle, additional, Beze, François, additional, Bideau, Karine, additional, Bidegain, Frédéric, additional, Billon, Laura, additional, Blaison, Gilles, additional, Blanc, Michèle, additional, Blanc, Pierre, additional, Blanchi, Sophie, additional, Blancho, Gilles, additional, Bland, Stephane, additional, Blondeau, Vincent, additional, Boldron, Amale, additional, Bon, Djemah, additional, Bonacorsi, Stéphane, additional, Bonzon, Lucas, additional, Borderon, Anaïs, additional, Botelho-Nevers, Elisabeth, additional, Bottlaender, Jacques, additional, Bouc-Boucher, Mathilde, additional, Bouchaud, Olivier, additional, Bougon, David, additional, Boukelikha, Khaled, additional, Bourlet, Thomas, additional, Boussoukaya, Samy, additional, Boutaleb, Hamza, additional, Bouziges, Nicole, additional, Bray, Philippe, additional, Bréchet, Caroline, additional, Bret, Laurent, additional, Brieu, Nathalie, additional, Briffaut, David, additional, Brochet, Christine, additional, Brulez-Des-Varannes, Stanislas, additional, Brunel, Valéry, additional, Brung-Lefebvre, Maud, additional, Bureau, Christophe, additional, Burucoa, Christophe, additional, Buscail, Louis, additional, Buzele, Rodolphe, additional, Cadot, Catherine, additional, Cadranel, Jean-Francois, additional, Cady, Anne, additional, Caillon, Jocelyne, additional, Camiade, Sabine, additional, Campillo, Bernard, additional, Carbonnel, Franck, additional, Carbonnelle, Etienne, additional, Cardot-Martin, Émilie, additional, Cariou, Marie-Estelle, additional, Carles, Michel, additional, Caron, Francois, additional, Carrara-Delarue, Lucrecia, additional, Carrier, Paul, additional, Castang, Céline, additional, Castellano, Inès, additional, Cattoir, Vincent, additional, Caubet, Olivier, additional, Causse, Xavier, additional, Chabrol, Amélie, additional, Chanard, Emmanuel, additional, Chatagnon, Thomas, additional, Chazouilleres, Olivier, additional, Chedanni, Halima, additional, Chevrel, Pauline, additional, Chirol, Catherine, additional, Chirouze, Catherine, additional, Chouquer, Renaud, additional, Clavière, Christophe, additional, Codreuil, Sylvain, additional, Colardelle, Philippe, additional, Combarnous, François, additional, Commeau, Grégory, additional, Cornillet, Anne, additional, Corvec, Stephane, additional, Costa, Yannick, additional, Couderc, Philippe, additional, Couffon, Caroline, additional, Courivaud, Cécile, additional, Courtade, Henri, additional, Cruchant, Etienne, additional, Cuen, David, additional, Culard, Jean-François, additional, Cung, Hong Ahn, additional, Dahyot, Sandrine, additional, D'Altéroche, Louis, additional, Dao, Manh Thông, additional, Darfeuil, Fabien, additional, Darnaud, Céline, additional, Daure, Sophie, additional, De Grossouvre-Taillefer, Ludivine, additional, Debriel, Dominique, additional, Debrueres, Jacques, additional, Decaens, Thomas, additional, Decambron, Audrey, additional, Decre-Grapinet, Dominique, additional, Degand, Nicolas, additional, Dehaye, Bruno, additional, Delacour, Thierry, additional, Delarbe, Jean-Marie, additional, Delobel, Pierre, additional, Delpierre, Éric, additional, Delrez, René, additional, Delvert, Didier, additional, Demartino, Sylvie, additional, Deniel, Marie-Clémence, additional, Denis, Bernard, additional, Derumeaux, Guy, additional, Desroches, Marine, additional, Dessein, Rodrigue, additional, Devillez, Simon, additional, Deweerdt, Didier, additional, Diamantis, Sylvain, additional, Diaz, Emmanuel, additional, Didier, Raffenot, additional, Dimartino, Vincent, additional, Dion, Ludivine, additional, Djemai, Mohand, additional, Doche, Christophe, additional, Donascimento, Maud, additional, Dorval, Ian, additional, Douala, Carol, additional, Doucet-Populaire, Florence, additional, Drouillat, Valérie, additional, Dubée, Vincent, additional, Dudermel, Anne-France, additional, Dumont, Betty, additional, Dupin, Clarisse, additional, Dupont, Mathieu, additional, Dupont, Philippe, additional, Dupuy, Marion, additional, Dupuychaffray, Jean-Pierre, additional, Durand, Francois, additional, Dusser, Pascale, additional, Duval, Valérie, additional, Duveau, Nicolas, additional, El-Azouzi, Abdelghani, additional, El-Gharras, Hynd, additional, Elsendoorn, Antoine, additional, Emile, Loïc, additional, Epaulard, Olivier, additional, Etchepare, Nicolas, additional, Etienne, Jean-Pierre, additional, Eveillard, Mathieu, additional, Evers, Annie, additional, Fach, Joelle, additional, Faizoun, Claudia, additional, Fangous, Marie-Sarah, additional, Farmachidi, Jean Pierre, additional, Fatome, Armelle, additional, Faulques, Bernard, additional, Faure, Karine, additional, Felix, Charlotte, additional, Ferec, Marc, additional, Ferey, Janine, additional, Ferracci, Serge, additional, Feryn, Jean-Marc, additional, Fesler, Pierre, additional, Fiette, Hélène, additional, Flevin, Emilie, additional, Floch, Pauline, additional, Fort, Eric, additional, Fortineau, Nicolas, additional, Fourcade, Jacques, additional, Fraissinet, François, additional, Franck, Patricia, additional, Françoise, Thiebaut, additional, Fratte, Serge, additional, Galempoix, Jean-Marc, additional, Garcera, Yves, additional, Garcia, Anne, additional, Garcon, Pierre, additional, Garret, Charlotte, additional, Gayet, Clement, additional, Gazeau, Pierre, additional, Gerber, Florence, additional, Gilles, Raclot, additional, Gillot, Jean-Michel, additional, Goarant, Eric, additional, Godreuil, Sylvain, additional, Goret, Julien, additional, Gorret, Julie, additional, Goujard, Cecile, additional, Goulenok, Thiphaine, additional, Gournay, Jérôme, additional, Gousseff, Marie, additional, Goux, Alain, additional, Graf, Emmanuelle, additional, Grange, Jean-Didier, additional, Gravet, Alain, additional, Greder-Belan, Alix, additional, Gronier, Olivier, additional, Grosset, Marine, additional, Guellouz, Sabra, additional, Guenenna, Dalida, additional, Guerbaa, Mohammed, additional, Guerin, Meggie, additional, Guerrot, Dominique, additional, Guery, Benoit, additional, Gugenheim, Jean, additional, Guidet, Bertrand, additional, Guiheneuf, Raphael, additional, Guillet-Caruba, Christelle, additional, Guimard, Yves, additional, Guinard, Jérome, additional, Guindre, Laure, additional, Hagege, Albert, additional, Hagege, Hervé, additional, Haineaux, Paul-Arthur, additional, Hamon, Rémy, additional, Hassan, Firas, additional, Hassine, Mélanie, additional, Helie, Ludovic, additional, Herber-Mayne, Anne, additional, Hervio, Pascale, additional, Héry-Arnaud, Geneviève, additional, Hitoto, Hikombo, additional, Hubsch, Théophile, additional, Hunaut, Nicolas, additional, Hurtova, Monika, additional, Husson-Wetzel, Stéphanie, additional, Hutin, Pascal, additional, Izopet, Théo, additional, Jacob, Jean-Louis, additional, Jacomet, Christine, additional, Jaffar-Bandjee, Marie-Christine, additional, Janvier, Fréderic, additional, Jaulhac, Benoît, additional, Jaureguiberry, Stephane, additional, Javaud, Nicolas, additional, Jeannot, Katty, additional, Joundy, Noureddine, additional, Kacem, Moez, additional, Karama, Rouis, additional, Karsenti, David, additional, Kempf, Marie, additional, Khatibi, Sarah, additional, Kikolski, Florence, additional, Kittirath, Christine, additional, Koch, Stephane, additional, Kouatchet-Achille, Tchamba, additional, Krummel, Yves, additional, La Combe, Karine, additional, Labarriere, Damien, additional, Laberenne, Jean-Eric, additional, Lacroix, Hervé, additional, Ladrat, Laure, additional, Lagarde, Stéphanie, additional, Lagasse, Jean-Paul, additional, Laggoune, Ahmed-Saïd, additional, Lambare, Benedicte, additional, Landgraf, Nathalie, additional, Landraud, Luce, additional, Laude, Jean-Francois, additional, Laurent, François, additional, Lavigne, Jean-Philippe, additional, Lavoue, Vincent, additional, Le Berre, Rozenn, additional, Le Goff, Vallérie, additional, Lebars, Hervé, additional, Lebrun, Armandine, additional, Lecapitaine, Anne-Lise, additional, Lechat, Sylvie, additional, Lecoustumier, Alain, additional, Ledreau, Gérard, additional, Lefevre, Benjamin, additional, Leflon, Véronique, additional, Lefort, Agnès, additional, Legall, Florence, additional, Legoff, Isabelle, additional, Legrand, Eric, additional, Lehello, Simon, additional, Le-Henaff-Bourhis, Catherine, additional, Leleu, Olivier, additional, Lelievre, Lucie, additional, Lemaignen, Adrien, additional, Lemaire, Xavier, additional, Le-Maout, Charles, additional, Lemblé, Chantal, additional, Lemeille, Yolande, additional, Lemenand, Olivier, additional, Lemeunier, Violaine, additional, Lemeur, Yannick, additional, Lemierre, Sylvia, additional, Leotard, Sophie, additional, Lepileur, Lucie, additional, Letellier-Demonchy, Claire, additional, Levecq, Hervé, additional, Levy, Marc, additional, Limal, Nicolas, additional, Locher, Christophe, additional, Lopez, Benjamin, additional, Loron, Marie-Charlotte, additional, Loulergue, Joelle, additional, Loury-Larivière, Isabelle, additional, Loustaud-Ratti, Véronique, additional, Macchi, Valèrie, additional, Machado, Moise, additional, Madaule, Serge, additional, Mainardi, Jean-Luc, additional, Males, Silvija, additional, Malherbe, Philippe, additional, Maneglier, Benjamin, additional, Marceau, Maryline, additional, Marcel, Kévin, additional, Marmonier, Alain, additional, Martha, Benoît, additional, Martin, Xavier, additional, Martin-Blondel, Guillaume, additional, Martinez, Camille, additional, Marty, Fabrice, additional, Marty, Patrick, additional, Matray, Olivier, additional, Maurin, Arnaud, additional, Mazerand, Sandie, additional, Mazouz, Nadia, additional, Medevielle, Muriel, additional, Mercat, Alain, additional, Méreghetti, Laurent, additional, Merzoug, Noureddine, additional, Meziane, Ilham, additional, Michaud, Anthony, additional, Michel, Marc, additional, Michel, Pierre, additional, Mignard, Sophie, additional, Milesi-Lecat, Anne-Marie, additional, Mion, Mathieu, additional, Mnasri, Nabil, additional, Mohareb, Abdo, additional, Mohib, Samir, additional, Moindrot, Henri, additional, Monlun, Eric, additional, Montewis, Audrey, additional, Morin, Thierry, additional, Moussata, Driffa, additional, Muller, Sandrine, additional, Muzellec, Valérie, additional, Nancey, Stéphane, additional, Nassereddine, Ahmad, additional, Naude, Sebastien, additional, Neau, Didier, additional, Ovidiu, Negru Calin, additional, Ngo, Thuy, additional, Ngwhotue, Marthe-Andree, additional, Nivet, Patrick, additional, Nordmann, Patrice, additional, Nousbaum, Jean-Baptiste, additional, Nouvel, Bernadette, additional, Obled, Stephane, additional, Oswald, Eric, additional, Otto, Marie-Pierre, additional, Pageaux, Georges-Philippe, additional, Papin, Gregory, additional, Parant, Fabrice, additional, Patenotte, Arnaud, additional, Paupard, Thierry, additional, Pauwels, Arnaud, additional, Pawlotsky, Jean Michel, additional, Pelloux, Hervé, additional, Perlemuter, Gabriel, additional, Peron, Jean-Marie, additional, Pestel-Caron, Martine, additional, Peter, Natasha, additional, Petillon, Sophie, additional, Petit, Richard, additional, Petitprez, Helene, additional, Pettinelli, Francois, additional, Phelip, Jean Marc, additional, Philit, Jean-Baptiste, additional, Phoutthasang, Valérie, additional, Pialoux, Gilles, additional, Piau-Couapel, Caroline, additional, Pichard, Benoit, additional, Pichon, Maxime, additional, Picon-Coste, Magali, additional, Picque, Marie, additional, Pierson, Henri, additional, Piques, Jean Francois, additional, Piton, Béatrice, additional, Planade, Orianne, additional, Plassart, Claire, additional, Plésiat, Patrick, additional, Ploy, Marie-Cécile, additional, Poubeau, Patrice, additional, Pouderoux, Philippe, additional, Pouedras, Pascal, additional, Pourbaix, Annabelle, additional, Poynard, Thierry, additional, Preau, Florence, additional, Pricope, Dumitrita, additional, Queffelec, Gwenaëlle, additional, Queneherve, Lucille, additional, Quentin, Thomas, additional, Raffenot, Didier, additional, Rakotoniaina, Daniella, additional, Ramanantsoa, Celine, additional, Ramarijaona, Solofoniaina, additional, Rami-Arab, Lila, additional, Raulin, Olivia, additional, Rebibou, Jean Michel, additional, Renault, David, additional, Rey, Philippe, additional, Riche, Agnès, additional, Rigaud, Jean Philippe, additional, Rivière, Antoine, additional, Rivière, Brigitte, additional, Robert, Jérôme, additional, Roblot, Pascal, additional, Roger, Helene, additional, Rolland, Christophe, additional, Rondinaud, Emilie, additional, Rosa-Hezode, Isabelle, additional, Roubille, Martine, additional, Rouquette, Olivier, additional, Roux, Juliette, additional, Ruimy, Raymond, additional, Sachot-Ollivier, Sonia, additional, Sailler, Laurent, additional, Salamant, Sarah, additional, Sarbu-Pop, Silvia, additional, Sartre, Jacques, additional, Schmitt, François, additional, Scribe-Outtas, Myriam, additional, Sefrioui, David, additional, Sehouane, Rachid, additional, Sekhri, Hacène, additional, Serfaty, Lawrence, additional, Sevin, Odile, additional, Shawali, Cédric, additional, Siladi, Souad, additional, Silvain, Christine, additional, Simon, Mireille, additional, Simonet, Batiste, additional, Sinayoko, Leila, additional, Sirach, Estelle, additional, Smati, Mustafa, additional, Smets, Aurélie, additional, Soltani, Dhaoui, additional, Sommabere, André, additional, Soulier-Guerin, Karine, additional, Soulillou, Jean Paul, additional, Soupison, Alain, additional, Souply, Laurent, additional, Soussy, Claude-James, additional, Stampfli, Claire, additional, Strullu, Bernard, additional, Suatean, Diana, additional, Tadjerouni, Nacer, additional, Talarmin, Jean-Philippe, additional, Tankovic, Jacques, additional, Tarroun, Abdullah, additional, Tchuenbou, Juliette, additional, Teboul, Jean-Louis, additional, Tedlaouti, Husni, additional, Tellini, Charlotte, additional, Thabut, Dominique, additional, Thannberger, Philippe, additional, Thiebault, Henri, additional, Thiebaut, Françoise, additional, Thomazeau, Joséphine, additional, Tielman, Guillaume, additional, Timsit, Jean-Francois, additional, Tognon, Patrick, additional, Tougeron, David, additional, Toure, Fatouma, additional, Tran, Albert, additional, Tranvouez, Jean-Luc, additional, Trésallet, Christophe, additional, Trubert, Lise, additional, Tsakiris, Laurent, additional, Twizeyimana, Eterne, additional, Vachee, Anne, additional, Valade, Hélène, additional, Valat, Isabelle, additional, Vandendriessche, Anne, additional, Vandermee, Nathalie, additional, Vanheste, Marc, additional, Varon, Emmanuelle, additional, Vasse, Marc, additional, Vasseur, Philippe, additional, Vaucel, Elisabeth, additional, Vauthier, Anne, additional, Verdavaine-Loidreau, Delphine, additional, Verdet, Charlotte, additional, Verdon, Renaud, additional, Vergnaud, Michel, additional, Véziris, Nicolas, additional, Vignaud, Guillaume, additional, Viguier, Jérôme, additional, Villemain, Marc, additional, Villeneuve, Laurent, additional, Vimont-Vicary, Alexandre, additional, Vincent, Thomas, additional, Vuillemenot, Jean-Baptiste, additional, Walewski, Violaine, additional, Warmoes, Elodie, additional, Watry, Hélène, additional, Weber, Jean-Christophe, additional, Witz, Marie Thérèse, additional, Woerther, Paul-Louis, additional, Yazdanpanah, Yazdan, additional, Zamfir, Oana, additional, Zarka, Jonathan, additional, Zavadil, Patrick, additional, Zeboudj, Nabil, additional, and Zerbib, Franck, additional

Published
2024
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13. Increased risk of non-hematological cancer in young patients with aortic stenosis: a retrospective cohort study

Author

Walid Saliba, Tamir Bental, Yaron Shapira, Shmuel Schwartzenberg, Alex Sagie, Moti Vaturi, Salim Adawi, Alexander Fuks, Ami Aronheim, and Avinoam Shiran

Subjects
Aortic stenosis, Cancer, Age, Risk, Diseases of the circulatory (Cardiovascular) system, RC666-701, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background We have previously reported an increased risk for non-hematological malignancies in young patients with moderate or severe aortic stenosis (AS). These findings were the result of a post-hoc analysis from a large echocardiography database and needed verification. Our aim was to determine, using a different study population, whether young patients with AS are at increased risk for cancer. Methods A large echocardiographic database was used to identify patients (age ≥ 20 years) with moderate or severe AS (study group) and patients without aortic stenosis (comparative group). The new occurrence of non-hematological malignancies was determined after the index date (first echo with moderate or severe AS or first recorded echo in the control group). Results The final study group included 7013 patients with AS and 98,884 without AS. During a median follow-up of 6.9 years (3.0–11.1) there were 10,705 new cases of non-hematological cancer. The crude incidence rate of cancer was higher in AS compared to non-AS patients (22.3 vs. 13.7 per 1000 patient-year, crude HR 1.58 (95%CI 1.46–1.71). After adjustment for relevant covariates, there was no difference between groups (HR 0.93, 95% CI 0.86–1.01). Only patients in the lowest age quartile (20–49.7 years), had an increased adjusted risk of cancer (HR 1.91, 95%CI 1.08–3.39). The HR for the risk of cancer associated with AS was inversely proportional to age (P

Published
2021
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14. Increased Rate of New-onset Left Bundle Branch Block in Patients With Bicuspid Aortic Stenosis Undergoing Transcatheter Aortic Valve Implantation (From a National Registry)

Author

Shiyovich, Arthur, Kornowski, Ran, Plakht, Ygal, Aviv, Yaron, Assa, Hana Vaknin, Assali, Abid, Bental, Tamir, Lessick, Jonathan, Kerner, Arthur, Segev, Amit, Barabash, Israel M., Goitein, Orly, Brodov, Yafim, Massalha, Eias, Finkelstein, Ariel, Perlman, Gidon Y., and Hamdan, Ashraf

Published
2021
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17. Hypothyroidism predicts worsened prognosis in patients undergoing percutaneous coronary intervention

Author

Ben Cohen, Tamir Bental, Liat Perl, Hana Vaknin Assa, Pablo Codner, Katia Orvin, Yeela Talmor Barkan, Amos Levi, Ran Kornowski, and Leor Perl

Subjects
hypothyroid, percutaneous coronary intervention (PCI), major cardiovascular adverse event, outcomes, ischemic heart disease, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

BackgroundThe link between thyroid dysfunction and cardiovascular disease is well established. Hypothyroidism has been significantly associated with increased risk of dyslipidemia, atherosclerosis and heart failure. However, little is known regarding its effect on patients undergoing percutaneous coronary intervention (PCI).AimThe aim of study was to examine the impact of concomitant hypothyroidism on mortality and major adverse cardiac event (MACE) in patients undergoing PCI.MethodsThe Rabin Medical Center PCI registry includes all consecutive patients who have undergone PCI between 2004 and 2020. We identified patients with prior diagnosis of hypothyroidism, and compared rates of mortality and MACE (comprising death, myocardial infarction, target vessel revascularization and/or coronary bypass surgery).ResultsAmong 28,274 patients, 1,922 (6.8%) were found to have hypothryoidism. These patients were older (70.3 ± 10.4 vs. 66.0 ± 11.8 y.o, P < 0.001) and more likely to be women (34.2% vs. 26.1%, P < 0.001). They had a higher prevalence of atrial fibrillation (10.8% vs. 7.7%, P < 0.001), chronic renal dysfunction (25.1% vs. 18.7%, P = 0.04) and dementia (2.9% vs. 1.8%, P = 0.004). PCI was performed on ACS setting in 52–54% of patients in both groups (p = 0.569). Unadjusted 5-year rates of all-cause mortality (26.9% vs. 20.3%, P < 0.001) and MACE (40.3% vs. 29.4%, P < 0.001) were higher for hypothyroid patients. A propensity match score was able to form 672 matched pairs of HT and control patients, showing similar results. Moreover, following multivariate analysis, TSH as a continuous parameter was associated with a higher risk of mortality and MACE (HR, 1.06 per additional 1 mIU/L; CI, 1.02–1.11; P < 0.001 and HR, 1.07; CI, 1.02–1.12; P < 0.001, respectively) at 5-year follow up.ConclusionIn our study, hypothyroidism confers worse outcomes in patients undergoing PCI. Further research is needed to establish effective ways to mitigate this augmented risk.

Published
2022
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19. Temporal Trends in Complex Percutaneous Coronary Interventions

Author

Mark Kheifets, Shelly Abigail Vons, Tamir Bental, Hana Vaknin-Assa, Gabriel Greenberg, Abed Samara, Pablo Codner, Guy Wittberg, Yeela Talmor Barkan, Leor Perl, Ran Kornowski, and Amos Levi

Subjects
trends, complexity, PCI—percutaneous coronary intervention, bifurcation, CTO (chronic total occlusion), left main, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

BackgroundAccumulated experience combined with technological advancements in percutaneous coronary interventions (PCI) over the past four decades, has led to a gradual increase in PCI utilization and complexity. We aimed to investigate the temporal trends in PCI complexity and the outcomes of complex PCI (C-PCI) in our institution.MethodsWe analyzed 20,301 consecutive PCI procedures performed over a 12-year period. C-PCI was defined as a procedure involving at least one of the following: Chronic total occlusion (CTO), left main (LM), bifurcation or saphenous vein graft (SVG) PCI. Four periods of 3-year time intervals were defined (2008–10, 2011–2013, 2014–2016, 2017–2019), and temporal trends in the rate and outcomes of C-PCI within these intervals were studied. Endpoints included mortality and major adverse cardiac events [MACE: death, acute myocardial infarction (MI), and target vessel revascularization (TVR)] at 1 year.ResultsA total of 5,647 (27.8%) C-PCI procedures were performed. The rate of C-PCI has risen significantly since 2,017 (31.2%, p < 0.01), driven mainly by bifurcation and LM interventions (p < 0.01). At 1-year, rates of death, acute MI, TVR and MACE, were all significantly higher in the C-PCI group (8.8 vs. 5.1%, 5.6 vs. 4.5%, 5.5 vs. 4.0%, 17.2 vs. 12.2%, p < 0.001 for all, respectively), as compared to the non-complex group. C-PCI preformed in the latter half of the study period (2014–2019) were associated with improved 1-year TVR (4.4% and 4.8% vs. 6.7% and 7.1%, p = 0.01, respectively) and MACE (13.8% and 13.5% vs. 17.3% and 18.2%, p = 0.001, respectively) rates compared to the earlier period (2007–2013). Death rate had not significantly declined with time.ConclusionIn the current cohort, we have detected a temporal increase in PCI complexity coupled with improved 1-year clinical outcomes in C-PCI.

Published
2022
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23. Trends in Ischemic Mitral Regurgitation Following ST-Elevation Myocardial Infarction Over a 20-Year Period

Author

Leor Perl, Tamir Bental, Katia Orvin, Hana Vaknin-Assa, Gabriel Greenberg, Pablo Codner, Yaron Shapira, Mordehay Vaturi, Alexander Sagie, and Ran Kornowski

Subjects
ischemic mitral regurgitation, myocardial infarction, primary percutaneous coronary, remodeling, ST-segment elevation myocardial infarction, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background: Ischemic mitral regurgitation (IMR) is a common complication of acute ST-elevation myocardial infarction (STEMI). Little is known regarding the impact of IMR over a long period of follow up.Methods: Of 3,208 consecutive STEMI patients from a prospective registry, full echocardiographic information was available for 2,985 patients between the years 2000 and 2020. We compared the two decades- 2001 to 2010 and 2011 to 2020, and assessed for the presence of IMR at baseline, 3 (range 2–6) months and 12 (range 10–14) months after the index event.Results: One thousand six hundred and sixty six patients were included in the first decade, 1,319 in the second. Mean patient age was 61.3 ± 12.3 years, 21.1% female patients in the first decade vs. 60.9 ± 12.0 years and 22.2% female in the second (p = 0.40 and p = 0.212, respectively). Rates of moderate IMR or above during the index admission were 17.2% in the first period and 9.3% in the second one (p < 0.001). After 3 months, the rate of IMR was 48.5% for those who suffered from IMR at baseline, vs. 9.5% for those without IMR at baseline (HR- 4.2, p < 0.001). Death rates for those with moderate IMR or above were 14.7% and 17.8% after 1 and 2 years, respectively, vs. 7.3 and 9.6% for those without (p < 0.001 for both). IMR was associated with 1 year mortality in multivariate analysis (HR-1.37; 1.09–2.20, p = 0.009), as well as in propensity score matched analysis (HR 1.29; CI: 1.07–1.91; p < 0.001).Conclusions: IMR is a common complication following acute STEMI, impacting prognosis. Rates of IMR have declined significantly over the years.

Published
2022
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32. Report from a large and comprehensive single-center Women’s Health Cardiology Clinic

Author

Shlomit Schuchalter Ludmir, Tamir Bental, Osnat Itzhaki Ben Zadok, Alon Eisen, Tzippy Shochat, Irit Heruti, Ran Kornowski, and Avital Porter

Subjects
Medicine
Abstract

Objective: This article describes the women population and work at a unique Women’s Health Cardiology Clinic in order to raise cardiovascular disease awareness with an emphasis on women-specific risk factors, and thus to improve women’s clinical outcomes. This expectantly will aid in opening similar centers allowing more women to get superior care. Methods: Electronic medical records of women referred to the Women’s Health Cardiology Clinic were analyzed. The statistical analysis is descriptive in nature. Women’s Health Cardiology Clinic personnel work as a multidisciplinary team, and patients receive specialized diagnostic tests and treatments. Referrals are by physicians according to traditional and women’s specific risk factors for cardiovascular disease. Results: 985 women visited the Women’s Health Cardiology Clinic, accumulating 2062 visits. Median age was 57.5 years. The majority of the women were menopausal (575 women, 58%), 62 pregnant with complications and 25 oncology patients. At least, 30% of women had diabetes/hypertension/or dyslipidemia. 72 women had a history of either cerebrovascular event or acute coronary syndrome, and 139 women had evidence of atherosclerosis. Overall, 388 women underwent endothelial function test, 40% of these women had a score indicating endothelial dysfunction. 277 women underwent a psychological intervention. Conclusion: Described here are the experiences from a multidisciplinary Women’s Health Cardiology Clinic using a gender-specific cardiovascular care approach for women geared toward improved health and wellbeing. It is of utmost importance that this report will raise women-specific cardiovascular disease risk factors awareness in order to promote women’s cardiovascular and overall health.

Published
2021
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35. Independent Impact of Peripheral Artery Disease on Percutaneous Coronary Intervention

Author

Leor Perl, Tamir Bental, Hana Vaknin‐Assa, Abid Assali, Pablo Codner, Yeela Talmor‐Barkan, Gabriel Greenberg, Abed Samara, Guy Witberg, Katia Orvin, and Ran Kornowski

Subjects
patient outcomes, percutaneous coronary intervention, peripheral artery disease, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background Peripheral artery disease (PAD) is a known risk factor for adverse outcomes in patients undergoing percutaneous coronary intervention. However, in some studies PAD is not an independent risk factor. We sought to examine the independent impact of PAD on a large prospective percutaneous coronary intervention registry. Methods and Results From our single‐center prospective percutaneous coronary intervention registry, we have retrospectively analyzed 25 690 patients (years 2004–2018). We examined the influence of PAD on short‐ and long‐term outcomes using both regression and propensity‐matched analyses. Patients with documented PAD (n=1610, 6.3% of total) were older (66.7±10.8 versus 65.4±12.1, P

Published
2020
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44. A Novel 8-Predictors Signature to Predict Complicated Disease Course in Pediatric-onset Crohn’s Disease: A Population-based Study

Author

Sarter, Hélène, Savoye, Guillaume, Marot, Guillemette, Ley, Delphine, Turck, Dominique, Hugot, Jean-Pierre, Vasseur, Francis, Duhamel, Alain, Wils, Pauline, Princen, Fred, Colombel, Jean-Frédéric, Gower-Rousseau, Corinne, Fumery, Mathurin, Al Hameedi, R, Al Khatib, M, Al Turk, S, Agoute, E, Andre, J, Antonietti, M, Aouakli, A, Armand, A, Armengol-Debeir, L, Aroichane, I, Assi, F, Aubet, J, Auxenfants, E, Avram, A, Ayafi-Ramelot, F, Azzouzi, K, Bankovski, D, Barbry, B, Bardoux, N, Baron, P, Baudet, A, Bayart, P, Bazin, B, Bebahani, A, Becqwort, J, Bellati, S, Benet, V, Benali, H, Benard, C, Benguigui, C, Ben Soussan, E, Bental, A, Berkelmans, I, Bernet, J, Bernou, K, Bernou-Dron, C, Bertot, P, Bertiaux-Vandaële, N, Bertrand, V, Billoud, E, Biron, N, Bismuth, B, Bleuet, M, Blondel, F, Blondin, V, Bobula, M, Bohon, P, Bondjemah, V, Boniface, E, Bonkovski, D, Bonnière, P, Bonvarlet, E, Bonvarlet, P, Boruchowicz, A, Bostvironnois, R, Boualit, M, Bouazza, A, Bouche, B, Boudaillez, C, Bourgeaux, C, Bourgeois, M, Bourguet, A, Bourienne, A, Boutaleb, H, Bouthors, A, Branche, J, Bray, G, Brazier, F, Breban, P, Bridenne, M, Brihier, H, Bril, L, Brung-Lefebvre, V, Bulois, P, Burgiere, P, Butel, J, Canva, J, Canva-Delcambre, V, Capron, J, Cardot, F, Carette, S, Carpentier, P, Cartier, E, Cassar, J, Cassagnou, M, Castex, J, Catala, P, Cattan, S, Catteau, S, Caujolle, B, Cayron, G, Chandelier, C, Chantre, M, Charles, J, Charneau, T, Chavance-Thelu, M, Cheny, A, Chirita, D, Choteau, A, Claerbout, J, Clergue, P, Coevoet, H, Cohen, G, Collet, R, Colin, M, Colombel, J, Coopman, S, Cordiez, L, Corvisart, J, Cortot, A, Couttenier, F, Crinquette, J, Crombe, V, Dadamessi, I, Daoudi, H, Dapvril, V, Davion, T, Dautreme, S, Debas, J, Decoster, S, Degrave, N, Dehont, F, Delatre, C, Delcenserie, R, Delesalle, D, Delette, O, Delgrange, T, Delhoustal, L, Delmotte, J, Demmane, S, Deregnaucourt, G, Descombes, P, Desechalliers, J, Desmet, P, Desreumaux, P, Desseaux, G, Desurmont, P, Devienne, A, Devouge, E, Devred, M, Devroux, A, Dewailly, A, Dharancy, S, Di Fiore, A, Djedir, D, Djedir, R, Doleh, W, Dreher-Duwat, M, Dubois, R, Duburque, C, Ducatillon, P, Duclay, J, Ducrocq, B, Ducrot, F, Ducrotte, P, Dufilho, A, Duhamel, C, Dujardin, D, Dumant-Forest, C, Dupas, J, Dupont, F, Duranton, Y, Duriez, A, Duveau, N, El Achkar, K, El Farisi, M, Elie, C, Elie-Legrand, M, Elkhaki, A, Eoche, M, Essmaeel, E, Evrard, D, Evrard, J, Fatome, A, Filoche, B, Finet, L, Flahaut, M, Flamme, C, Foissey, D, Fournier, P, Foutrein-Comes, M, Foutrein, P, Fremond, D, Frere, T, Gallais, P, Gamblin, C, Ganga, S, Gerard, R, Geslin, G, Gheyssens, Y, Ghossini, N, Ghrib, S, Gilbert, T, Gillet, B, Godart, D, Godard, P, Godchaux, J, Godchaux, R, Goegebeur, G, Goria, O, Gottrand, F, Gower, P, Grandmaison, B, Groux, M, Guedon, C, Guerbeau, L, Gueroult-Dero, M, Guillard, J, Guillem, L, Guillemot, F, Guimberd, D, Haddouche, B, Hakim, S, Hanon, D, Hautefeuille, V, Heckestweiller, P, Hecquet, G, Hedde, J, Hellal, H, Henneresse, P, Heyman, B, Heraud, M, Herve, S, Hochain, P, Houssin-Bailly, L, Houcke, P, Huguenin, B, Iobagiu, S, Istanboli, S, Ivanovic, A, Iwanicki-Caron, I, Janicki, E, Jarry, M, Jeu, J, Joly, J, Jonas, C, Jouvenet, A, Katherin, F, Kerleveo, A, Khachfe, A, Kiriakos, A, Kiriakos, J, Klein, O, Kohut, M, Kornhauser, R, Koutsomanis, D, Laberenne, J, Lacotte, E, Laffineur, G, Lagarde, M, Lalanne, A, Lalieu, A, Lannoy, P, Lapchin, J, Laprand, M, Laude, D, Leblanc, R, Lecieux, P, Lecleire, S, Leclerc, N, Le Couteulx, C, Ledent, J, Lefebvre, J, Lefiliatre, P, Le Goffic, C, Legrand, C, Le Grix, A, Lelong, P, Leluyer, B, Lemaitre, C, Lenaerts, C, Lepeut, G, Lepileur, L, Leplat, A, Lepoutre-Dujardin, E, Leroi, H, Leroy, M, Le Roy, P, Lesage, B, Lesage, J, Lesage, X, Lescanne-Darchis, I, Lescut, J, Lescut, D, Leurent, B, Levy, P, Lhermie, M, Libier, L, Lion, A, Lisambert, B, Loge, I, Loire, F, Loreau, J, Louf, S, Louvet, A, Lubret, L, Luciani, M, Lucidarme, D, Lugand, J, Macaigne, O, Maetz, D, Maillard, D, Mancheron, H, Manolache, O, Marks-Brunel, A, Marre, C, Marti, R, Martin, F, Martin, G, Marzloff, E, Mathurin, P, Mauillon, J, Maunoury, V, Maupas, J, Medam Djomo, M, Mechior, C, Melki, Z, Mesnard, B, Metayer, P, Methari, L, Meurisse, B, Meurisse, F, Michaud, L, Mirmaran, X, Modaine, P, Monthe, A, Morel, L, Mortier, P, Moulin, E, Mouterde, O, Mozziconaci, N, Mudry, J, Nachury, M, Ngo, M, N’guyen Khac, Eric, Notteghem, B, Ollevier, V, Ostyn, A, Ouraghi, A, Oussadou, B, Ouvry, D, Paillot, B, Painchart, C, Panien-Claudot, N, Paoletti, C, Papazian, A, Parent, B, Pariente, B, Paris, J, Patrier, P, Paupard, T, Pauwels, B, Pauwels, M, Penninck, E, Petit, R, Piat, M, Piotte, S, Plane, C, Plouvier, B, Pollet, E, Pommelet, P, Pop, D, Pordes, C, Pouchain, G, Prades, P, Prevost, A, Prevost, J, Quartier, G, Quesnel, B, Queuniet, A, Quinton, J, Rabache, A, Rabelle, P, Raclot, G, Ratajczyk, S, Rault, D, Razemon, V, Reix, N, Renaut-Vantroys, T, Revillion, M, Riachi, G, Richez, C, Robinson, P, Rodriguez, J, Roger, J, Roux, J, Rudelli, A, Saber, A, Savoye, G, Schlossberg, P, Sefrioui, D, Segrestin, M, Seguy, D, Seminur, C, Serin, M, Seryer, A, Sevenet, F, Shekh, N, Silvie, J, Simon, V, Spyckerelle, C, Talbodec, N, Tavernier, N, Tchandeu, H, Techy, A, Thelu, J, Thevenin, A, Thiebault, H, Thomas, J, Thorel, J, Thuillier, C, Tielman, G, Tode, M, Toisin, J, Tonnel, J, Touchais, J, Toumelin, P, Touze, Y, Tranvouez, J, Triplet, C, Triki, N, Turck, D, Uhlen, S, Vaillant, E, Valmage, C, Vanco, D, Vandaele-Bertiaux, N, Vandamme, H, Vanderbecq, E, Vander Eecken, E, Vandermolen, P, Vandevenne, P, Vandeville, L, Vandewalle, A, Vandewalle, C, Vaneslander, P, Vanhoove, J, Vanrenterghem, A, Vanveuren, C, Varlet, P, Vasies, I, Verbiese, G, Verlynde, J, Vernier-Massouille, G, Vermelle, P, Verne, C, Vezilier-Cocq, P, Vigneron, B, Vincendet, M, Viot, J, Voiment, Y, Wacrenier, A, Waeghemaecker, L, Wallez, J, Wantiez, M, Wartel, F, Weber, J, Willocquet, J, Wizla, N, Wolschies, E, Zaharia, O, Zaoui, S, Zalar, A, Zaouri, B, Zellweger, A, Ziade, C, Beaugerie, L, Allez, M, Ruemmele, F, Lamer, A, Roy, M, CHU Lille, Institute for Translational Research in Inflammation - U 1286 (INFINITE (Ex-Liric)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Nutrition, Inflammation et axe Microbiote-Intestin-Cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Normandie Université (NU), Service d'Hépato-Gastroentérologie [CHU Rouen], Hôpital Charles Nicolle [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service des Maladies de l'Appareil Digestif et de la Nutrition [CHRU Lille], Hôpital Claude Huriez [Lille], CHU Lille-CHU Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre Hospitalier Universitaire de Reims (CHU Reims), Périnatalité et Risques Toxiques - UMR INERIS_I 1 (PERITOX), Institut National de l'Environnement Industriel et des Risques (INERIS)-Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, CHU Amiens-Picardie, Registre EPIMAD, Normandie Université (NU)-Normandie Université (NU)-CHU Amiens-Picardie-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Department of Colloid Chemistry [Potsdam], Max Planck Institute of Colloids and Interfaces, Max-Planck-Gesellschaft-Max-Planck-Gesellschaft, Groupe de Recherche sur l'alcool et les pharmacodépendances - UMR INSERM_S 1247 (GRAP), and Université de Picardie Jules Verne (UPJV)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Crohn’s disease, inflammatory bowel disease, complication, genetics, prediction, prognosis, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; Background The identification of patients at high risk of a disabling disease course would be invaluable in guiding initial therapy in Crohn’s disease (CD). Our objective was to evaluate a combination of clinical, serological, and genetic factors to predict complicated disease course in pediatric-onset CD. Methods Data for pediatric-onset CD patients, diagnosed before 17 years of age between 1988 and 2004 and followed more than 5 years, were extracted from the population-based EPIMAD registry. The main outcome was defined by the occurrence of complicated behavior (stricturing or penetrating) and/or intestinal resection within the 5 years following diagnosis. Lasso logistic regression models were used to build a predictive model based on clinical data at diagnosis, serological data (ASCA, pANCA, anti-OmpC, anti-Cbir1, anti-Fla2, anti-Flax), and 369 candidate single nucleotide polymorphisms. Results In total, 156 children with an inflammatory (B1) disease at diagnosis were included. Among them, 35% (n = 54) progressed to a complicated behavior or an intestinal resection within the 5 years following diagnosis. The best predictive model (PREDICT-EPIMAD) included the location at diagnosis, pANCA, and 6 single nucleotide polymorphisms. This model showed good discrimination and good calibration, with an area under the curve of 0.80 after correction for optimism bias (sensitivity, 79%, specificity, 74%, positive predictive value, 61%, negative predictive value, 87%). Decision curve analysis confirmed the clinical utility of the model. Conclusions A combination of clinical, serotypic, and genotypic variables can predict disease progression in this population-based pediatric-onset CD cohort. Independent validation is needed before it can be used in clinical practice.

Published
2023

48. Implantable Cardioverter Defibrillator for the Primary Prevention of Sudden Cardiac Death among Patients With Cancer

Author

Itzhaki Ben Zadok, Osnat, primary, Nardi Agmon, Inbar, additional, Neiman, Victoria, additional, Eisen, Alon, additional, Golovchiner, Gregory, additional, Bental, Tamir, additional, Schamroth-Pravda, Nili, additional, Kadmon, Ehud, additional, Goldenberg, Gustavo Ruben, additional, Erez, Aharon, additional, Kornowski, Ran, additional, and Barsheshet, Alon, additional

Published
2023
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