1. Multimodal Imaging Approach in a Patient with Vogt-Koyanagi-Harada-like Syndrome Due to Dabrafenib and Trametinib Use for Cutaneous Melanoma.
- Author
-
Bellanca RF, Pinna A, Catania G, Belcastro E, Angi M, and D'Amico Ricci G
- Subjects
- Female, Humans, Middle Aged, Inflammation complications, Multimodal Imaging, Melanoma, Cutaneous Malignant, Melanoma diagnosis, Melanoma drug therapy, Melanoma complications, Skin Neoplasms diagnosis, Skin Neoplasms drug therapy, Skin Neoplasms complications, Uveomeningoencephalitic Syndrome chemically induced, Uveomeningoencephalitic Syndrome diagnosis, Uveomeningoencephalitic Syndrome drug therapy, Uveitis complications, Iridocyclitis complications
- Abstract
Purpose: To describe a case of ocular inflammation associated with dabrafenib and trametinib chemotherapy for cutaneous melanoma by using a multimodal image approach., Materials and Methods: We report on a 51-year-old woman with Vogt-Koyanagi-Harada-like syndrome, which occurred while she was undergoing treatment with dabrafenib and trametinib for cutaneous melanoma. The patient complained of sudden, bilateral vision loss of 2 days' duration. Anatomical and functional improvement was observed after administration of systemic steroids and cessation of chemotherapy. Later on, 6 weeks after restarting dabrafenib, she had an episode of granulomatous anterior uveitis, which was successfully managed with topical mydriatics and steroids. Strict follow-up with multimodal imaging was performed until recovery., Conclusions: This report emphasizes the importance of strict ophthalmological follow-up with multimodal imaging in patients receiving dabrafenib and trametinib, and the need for a multidisciplinary approach in the management of ocular inflammation during chemotherapy.
- Published
- 2023
- Full Text
- View/download PDF