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Multimodal Imaging Approach in a Patient with Vogt-Koyanagi-Harada-like Syndrome Due to Dabrafenib and Trametinib Use for Cutaneous Melanoma.
- Source :
-
Ocular immunology and inflammation [Ocul Immunol Inflamm] 2023 Feb; Vol. 31 (2), pp. 402-406. Date of Electronic Publication: 2022 Feb 03. - Publication Year :
- 2023
-
Abstract
- Purpose: To describe a case of ocular inflammation associated with dabrafenib and trametinib chemotherapy for cutaneous melanoma by using a multimodal image approach.<br />Materials and Methods: We report on a 51-year-old woman with Vogt-Koyanagi-Harada-like syndrome, which occurred while she was undergoing treatment with dabrafenib and trametinib for cutaneous melanoma. The patient complained of sudden, bilateral vision loss of 2 days' duration. Anatomical and functional improvement was observed after administration of systemic steroids and cessation of chemotherapy. Later on, 6 weeks after restarting dabrafenib, she had an episode of granulomatous anterior uveitis, which was successfully managed with topical mydriatics and steroids. Strict follow-up with multimodal imaging was performed until recovery.<br />Conclusions: This report emphasizes the importance of strict ophthalmological follow-up with multimodal imaging in patients receiving dabrafenib and trametinib, and the need for a multidisciplinary approach in the management of ocular inflammation during chemotherapy.
- Subjects :
- Female
Humans
Middle Aged
Inflammation complications
Multimodal Imaging
Melanoma, Cutaneous Malignant
Melanoma diagnosis
Melanoma drug therapy
Melanoma complications
Skin Neoplasms diagnosis
Skin Neoplasms drug therapy
Skin Neoplasms complications
Uveomeningoencephalitic Syndrome chemically induced
Uveomeningoencephalitic Syndrome diagnosis
Uveomeningoencephalitic Syndrome drug therapy
Uveitis complications
Iridocyclitis complications
Subjects
Details
- Language :
- English
- ISSN :
- 1744-5078
- Volume :
- 31
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Ocular immunology and inflammation
- Publication Type :
- Academic Journal
- Accession number :
- 35113757
- Full Text :
- https://doi.org/10.1080/09273948.2021.2025250