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3. Predictors, Risk Factors, and Incidence Rates of Psoriatic Arthritis Development in Psoriasis Patients: A Systematic Literature Review and Meta-Analysis

Author

Zabotti, Alen, De Lucia, Orazio, Sakellariou, Garifallia, Batticciotto, Alberto, Cincinelli, Gilberto, Giovannini, Ivan, Idolazzi, Luca, Maioli, Gabriella, Tinazzi, Ilaria, Aletaha, Daniel, De Vita, Salvatore, Marchesoni, Antonio, Smolen, Josef, Iagnocco, Annamaria, McGonagle, Dennis, and Caporali, Roberto

Published
2021
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8. Fibromyalgia: one year in review 2023

Author

Giorgi, Valeria, primary, Bazzichi, Laura, additional, Batticciotto, Alberto, additional, Pellegrino, Greta, additional, Di Franco, Manuela, additional, Sirotti, Silvia, additional, Atzeni, Fabiola, additional, Alciati, Alessandra, additional, Salaffi, Fausto, additional, and Sarzi Puttini, Piercarlo, additional

Published
2023
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10. Venous and arterial thromboembolic risk of Janus kinase inhibitors: a systematic review with meta-analysis.

Author

Campanaro, Francesco, Zaffaroni, Andrea, Cacioppo, Elettra, Cappelli, Antonella, Bertù, Lorenza, Donadini, Marco Paolo, Squizzato, Alessandro, and Batticciotto, Alberto

Subjects
THROMBOEMBOLISM risk factors, VEINS, META-analysis, MEDICAL information storage & retrieval systems, CONFIDENCE intervals, INFLAMMATION, SYSTEMATIC reviews, RISK assessment, JANUS kinases, DESCRIPTIVE statistics, NEUROTRANSMITTER uptake inhibitors, IMMUNOLOGIC diseases, DRUG side effects, MEDLINE, ODDS ratio
Abstract

Objective Preliminary data led licencing authorities to alert clinicians of an increased venous thrombotic risk associated to the use of Janus kinase (JAK) inhibitors (JAKi). We performed a systematic review to estimate the risk of venous and arterial thrombosis associated to JAKi for the treatment of immune-mediated inflammatory diseases (IMIDs). Methods Randomized controlled trials (RCTs) on JAKi in patients with IMIDs were identified by the MEDLINE and EMBASE databases until October 2021. Risk of bias was assessed according to Cochrane criteria. The beta-binomial model was applied to calculate pooled odds ratio (OR) and corresponding 95% CI. The PROSPERO registration number is CRD42022324143. Results We have included one phase I, 21 phase II, three phase II–III and 36 phase III RCTs for a total of 19 443 patients in the JAKi group and 6354 in the control group. Thirty-one (unweighted rate 0.16%; 95% CI: 0.10, 0.21) events were reported in the JAKi group and 20 (unweighted rate 0.22%; 95% CI: 0.12, 0.32) in the control group in a mean follow-up of 16.8 weeks. IMID patients treated with JAKi did not have an increased thromboembolic risk compared with those treated with placebo (OR 0.82; 95% CI: 0.43, 1.56). No statistically different results were seen in subanalyses for each investigated IMID, drug and dosage. Conclusion JAKi do not increase thromboembolic risk compared with placebo in IMID patients enrolled in selected RCTs. [ABSTRACT FROM AUTHOR]

Published
2023
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15. Prevalence of hepatitis B virus infection and risk of reactivation in rheumatic population undergoing biological therapy

Author

Ditto, Maria Chiara, Parisi, Simone, Varisco, Valentina, Talotta, Rossella, Batticciotto, Alberto, Antivalle, Marco, Gerardi, Maria Chiara, Agosti, Michele, Borrelli, Richard, Fusaro, Enrico, and Sarzi-Puttini, Piercarlo

Subjects
Hepatitis B virus, Hepatitis B Surface Antigens, Immunology, Hepatitis B, Antiviral Agents, Arthritis, Rheumatoid, Biological Therapy, Rheumatology, Prevalence, Humans, Immunology and Allergy, Tumor Necrosis Factor Inhibitors, Virus Activation, Hepatitis B Antibodies
Abstract

Hepatitis B (HBV) is a common comorbidity among rheumatic patients. The prevalence of HBV infection and the rate of reactivation remain unclear. The literature data suggested a higher risk in chronic than in past infection. Currently, the literature data are mostly focused on anti-TNF and rituximab. This retrospective observational study aimed to analyse the prevalence of HBV infection and the risk of viral reactivation in a population of rheumatic patients undergoing anti-TNF and non-anti-TNF agents.We analysed 1216 rheumatic patients, treated with both csDMARDs and bDMARDs between 2006 and 2017. Serologic markers for HBV (HBsAg, anti-HBs, anti-HBc) were performed prior and during biologic treatment. Patients with chronic or resolved infection were monitored every 3 months.The prevalence of HBV in our cohort was 15.7% (chronic infection: 0.4%, resolved infection: 12.6%, anti-HBc positivity alone: 2.6%). 12 (6.2%) out of 191 HBV infected patients experienced a reactivation. All of them showed markers of past infection. One patient experienced HBV reactivation despite lamivudine. Only one patient experienced acute hepatitis, probably due to the interruption of immunosuppressors in anticipation of surgery, not preceded by any HBV prophylactic treatment.HBV reactivation is a rare event in patients treated with a bDMARD and it can also occur while taking lamivudine, not only in chronic carriers (as per the literature data) but also in inactive ones. Regular screening followed by prompt treatment can prevent symptoms or complications. Due to the risk of hepatitis following the immune reconstitution, an antiviral therapy should be considered in the case of sudden discontinuation of csDMARDs or bDMARD.

Published
2021
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16. Fibromyalgia severity according to age categories: results of a cross-sectional study from a large national database

Author

Di Carlo, Marco, Farah, Sonia, Bazzichi, Laura, Atzeni, Fabiola, Govoni, Marcello, Biasi, Giovanni, Di Franco, Manuela, Mozzani, Flavio, Gremese, Elisa, Dagna, Lorenzo, Batticciotto, Alberto, Fischetti, Fabio, Giacomelli, Roberto, Guiducci, Serena, Guggino, Giuliana, Bentivegna, Mario, Gerli, Roberto, Salvarani, Carlo, Bajocchi, Gianluigi, Ghini, Marco, Iannone, Florenzo, Giorgi, Valeria, Cirillo, Mariateresa, Bonazza, Sara, Barbagli, Stefano, Gioia, Chiara, Marino, Noemi Giuliana, Capacci, Annunziata, Cavalli, Giulio, Cappelli, Antonella, Carubbi, Francesco, Nacci, Francesca, Riccucci, Ilenia, Cutolo, Maurizio, Sinigaglia, Luigi, Sarzi-Puttini, Piercarlo, Salaffi, Fausto, Gremese, Elisa (ORCID:0000-0002-2248-1058), Di Carlo, Marco, Farah, Sonia, Bazzichi, Laura, Atzeni, Fabiola, Govoni, Marcello, Biasi, Giovanni, Di Franco, Manuela, Mozzani, Flavio, Gremese, Elisa, Dagna, Lorenzo, Batticciotto, Alberto, Fischetti, Fabio, Giacomelli, Roberto, Guiducci, Serena, Guggino, Giuliana, Bentivegna, Mario, Gerli, Roberto, Salvarani, Carlo, Bajocchi, Gianluigi, Ghini, Marco, Iannone, Florenzo, Giorgi, Valeria, Cirillo, Mariateresa, Bonazza, Sara, Barbagli, Stefano, Gioia, Chiara, Marino, Noemi Giuliana, Capacci, Annunziata, Cavalli, Giulio, Cappelli, Antonella, Carubbi, Francesco, Nacci, Francesca, Riccucci, Ilenia, Cutolo, Maurizio, Sinigaglia, Luigi, Sarzi-Puttini, Piercarlo, Salaffi, Fausto, and Gremese, Elisa (ORCID:0000-0002-2248-1058)

Abstract

Objectives: The role of age in influencing the severity of fibromyalgia (FM) is still controversial. The aim of this study is to define the contribution of age in the severity of FM from data from a large national database. Methods: This cross-sectional study included adult patients with FM diagnosed according to the 2010/2011 American College of Rheumatology criteria. Disease severity was assessed with the revised Fibromyalgia Impact Questionnaire (FIQR) and the modified Fibromyalgia Assessment Status (FAS 2019mod). Patients were grouped into five age categories (between 18-40 years, between 41-50 years, between 51-60 years, between 61-70 years, and ≥71 years). Differences in disease severity between groups were assessed by one-way analysis of variance (ANOVA). Results: The study included 2889 patients (199 males and 2690 females), mean age of 52.58 (±11.82) years, with a mean FIQR score of 59.22 (±22.98) and a mean FAS 2019mod of 25.50 (±8.66). Comparing the mean values of the various indices between age categories, there were no statistically significant differences between the groups for FIQR total score and FAS 2019mod. However, the 60-70 years category showed the lowest scores for both scales. The main difference emerged for the FIQR physical function subscale, where the ≥71 years category showed significantly higher scores (p<0.05) compared the 18-40 years category. Conclusions: The severity of FM has a significant level of stationarity according to age categories. Patients between 60-70 years have a lower disease burden. Physical function is the health domain with the most significant difference between the groups.

Published
2022

18. Sociodemographic factors in fibromyalgia: results from the Italian Fibromyalgia Registry

Author

Atzeni, Fabiola, primary, Alciati, Alessandra, additional, Bazzichi, Laura, additional, Govoni, Marcello, additional, Biasi, Giovanni, additional, Di Franco, Manuela, additional, Mozzani, Flavio, additional, Gremese, Elisa, additional, Dagna, Lorenzo, additional, Batticciotto, Alberto, additional, Fischetti, Fabio, additional, Giacomelli, Roberto, additional, Guiducci, Serena, additional, Guggino, Giuliana, additional, Bentivegna, Mario, additional, Gerli, Roberto, additional, Salvarani, Carlo, additional, Bajocchi, Gianluigi, additional, Ghini, Marco, additional, Iannone, Florenzo, additional, Giorgi, Valeria, additional, Di Carlo, Marco, additional, Farah, Sonia, additional, Bonazza, Sara, additional, Barbagli, Stefano, additional, Gioia, Chiara, additional, Marino, Noemi Giuliana, additional, Capacci, Annunziata, additional, Cavalli, Giulio, additional, Carubbi, Francesco, additional, Nacci, Francesca, additional, Riccucci, Ilenia, additional, Cutolo, Maurizio, additional, Sinigaglia, Luigi, additional, Sarzi-Puttini, Piercarlo, additional, and Salaffi, Fausto, additional

Published
2022
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21. Contributors

Author

Abdurakhmanov, Alexander, primary, Abu-Shakra, Mahmoud, additional, Afanasyeva, Marina, additional, Agmon-Levin, Nancy, additional, Albert, Paul J., additional, Almeida, Isabel, additional, Alves, Rute, additional, Amital, Howard, additional, Andrade, Paulo, additional, Antonelli, Alessandro, additional, Puccetti, Antonio, additional, Arango, María-Teresa, additional, Atzeni, Fabiola, additional, Baird, Alison E., additional, Balbir-Gurman, Alexandra, additional, Bashi, Tomer, additional, Batticciotto, Alberto, additional, Benucci, Maurizio, additional, Blank, Miri, additional, Bogdanos, Dimitrios P., additional, Bombardieri, S., additional, Borella, E., additional, Bosis, Samantha, additional, Bournia, Vasiliki Kalliopi, additional, Brandão, Mariana, additional, Braun-Moscovici, Yolanda, additional, Brender-Gotlieb, Neta, additional, Cainelli, Francesca, additional, Caldas, Cezar Augusto Muniz, additional, Campar, A., additional, Carvalheiras, Graziela, additional, Cervera, R., additional, Chapman, Joab, additional, Chastain, Emily M.L., additional, Claudio, Lunardi, additional, Cohen, Eytan, additional, Conti, Fabrizio, additional, Correia, J., additional, Carvalho, Jozélio Freire de, additional, Rossa, A. Della, additional, Detrick, Barbara, additional, Deutsch, Melanie, additional, Di Domenicantonio, Andrea, additional, Domeneghetti, M., additional, Domingues, Vital, additional, Doria, A., additional, Dow, Coad Thomas, additional, Dreyfus, David H., additional, Drouin, Elise E., additional, Dubaniewicz, Anna, additional, Durai, Malarvizhi, additional, Ebringer, Alan, additional, Ehrenfeld, Michael, additional, Elisa, Tinazzi, additional, Esposito, Susanna, additional, Fallahi, Poupak, additional, Faria, Raquel, additional, Farinha, Fátima, additional, Ferrannini, Ele, additional, Ferrari, Silvia Martina, additional, Ferreira, Alvaro, additional, Ferrão, C., additional, Garg, Ravindra Kumar, additional, Gatto, M., additional, Ghirardello, A., additional, Giovanna, Zanoni, additional, Giuseppe, Patuzzo, additional, Givaty, Gili, additional, Guilherme, Luiza, additional, Hammerstad, Sara Salehi, additional, Hodak, Emillia, additional, Hooks, John J., additional, Iaccarino, L., additional, Invernizzi, Pietro, additional, Israeli, Eitan, additional, Jamin, Christophe, additional, Janket, Sok-Ja, additional, Jarčuška, Peter, additional, Jones, Rodney P., additional, Kalil, Jorge, additional, Kanasi, Eleni, additional, Kivity, Shaye, additional, Konikoff, Tom, additional, Kozáková, D., additional, Krause, Ilan, additional, Lerner, Aaron, additional, Lidar, Merav, additional, Ling, Eduard, additional, Mahajna, Hussein, additional, Mahroum, Naim, additional, Maoz-Segal, Ramit, additional, Marinho, António, additional, Marshall, Trevor G., additional, Martinelli, Maria, additional, Marzia, Dolcino, additional, Mavragani, Clio P., additional, Mendonça, Teresa, additional, Miller, Stephen D., additional, Mimouni, Daniel, additional, Monteiro, Marta, additional, Moudgil, Kamal D., additional, Moulton, Vaishali R., additional, Moutsopoulos, Haralampos M., additional, Nagpal, Kamalpreet, additional, Neves, Esmeralda, additional, Nussenblatt, Robert, additional, Ollech, Ayelet, additional, Palma, L., additional, Pasoto, Sandra Gofinet, additional, Pella, Daniel, additional, Pereira, Cláudia, additional, Perricone, Carlo, additional, Petríková, Jana, additional, Proal, Amy D., additional, Rashid, Taha, additional, Reif, Shimon, additional, Renaudineau, Yves, additional, Ribeiro, Francinne Machado, additional, Rigante, Donato, additional, Rigopoulou, Eirini I., additional, Rose, Noel R., additional, Rosário, Cristina, additional, Rovenský, J., additional, Sakkas, Lazaros I., additional, Sarzi-Puttini, Piercarlo, additional, Seguro, Luciana Parente Costa, additional, Semino, Margherita, additional, Shoenfeld, Yehuda, additional, Silva, S., additional, Simonin, Laurent, additional, Smyk, Daniel S., additional, Sousa, Rita Catarina Medeiros, additional, Stagnaro, C., additional, Steere, Allen C., additional, Strle, Klemen, additional, Tektonidou, Maria G., additional, Tishler, Moshe, additional, Tomer, Yaron, additional, Toubi, Elias, additional, Tsokos, George C., additional, Vadasz, Zahava, additional, Valesini, Guido, additional, Vasconcelos, Carlos, additional, Vasconcelos, Júlia, additional, Vassilopoulos, Dimitrios, additional, Venkatesha, Shivaprasad H., additional, Vento, Sandro, additional, Viale, Christophe, additional, Villanueva, Ronald, additional, Vita, Pedro, additional, Wilson, Clyde, additional, Youinou, Pierre, additional, Záňová, E., additional, Zandman-Goddard, Gisele, additional, and Zen, M., additional

Published
2015
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22. Cannabis and Autoimmunity: Possible Mechanisms of Action

Author

Giorgi,Valeria, Marotto,Daniela, Batticciotto,Alberto, Atzeni,Fabiola, Bongiovanni,Sara, and Sarzi-Puttini,Piercarlo

Subjects
ImmunoTargets and Therapy
Abstract

Valeria Giorgi1 1, Daniela Marotto2 2, Alberto Batticciotto3 3, Fabiola Atzeni4 4, Sara Bongiovanni1 1, Piercarlo Sarzi-Puttini1 1 1Rheumatology Unit, Internal Medicine Department, ASST Fatebenefratelli-Sacco, Milan University School of Medicine, Milan, Italy; 2Rheumatology Unit, ATS Sardegna, P. Dettori Hospital, Tempio Pausania, Italy; 3Rheumatology Unit, Internal Medicine Department, ASST Settelaghi, Ospedale Di Circolo - Fondazione Macchi, Varese, Italy; 4Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Messina, Messina, ItalyCorrespondence: Valeria Giorgi Email vale.gio@fastwebnet.itAbstract: Medical cannabis (MC) describes the usually inhaled or ingested use of a cannabis plant or cannabis extract for medicinal purposes. The action of whole cannabis plants is extremely complex because their large number of active compounds not only bind to a plethora of different receptors but also interact with each other both synergistically and otherwise. Renewed interest in the medicinal properties of cannabis has led to increasing research into the practical uses of cannabis derivatives, and it has been found that the endocannabinoid system (particularly CB2 receptor activation) is a possible target for the treatment of inflammatory and the autoimmune diseases related to immune cell activation. However, in vivo findings still lack, creating difficulties in applying translational cannabinoid research to human immune functions. In this review, we summarized the main mechanisms of action of medical cannabis plant especially regarding the immune system and the endocannabinoid system, looking at preliminary clinical data in three most important autoimmune diseases of three different specialities: rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease.Keywords: cannabis, cannabis derivatives, cannabidiol, tetrahydrocannabinol, terpenes, autoimmunity, auto-antibodies

Published
2021

26. Fibromyalgia position paper

Author

Sarzi-Puttini, Piercarlo, primary, Giorgi, Valeria, additional, Atzeni, Fabiola, additional, Gorla, Roberto, additional, Kosek, Eva, additional, Choy, Ernest H., additional, Bazzichi, Laura, additional, Häuser, Winfred, additional, Ablin, Jacob N., additional, Aloush, Valerie, additional, Buskila, Dan, additional, Amital, Howard, additional, Da Silva, Jose A.P., additional, Perrot, Serge, additional, Morlion, Bart, additional, Polati, Enrico, additional, Schweiger, Vittorio, additional, Coaccioli, Stefano, additional, Varrassi, Giustino, additional, Di Franco, Manuela, additional, Torta, Riccardo, additional, Øien Forseth, Karin Maria, additional, Mannerkorpi, Kaisa, additional, Salaffi, Fausto, additional, Di Carlo, Marco, additional, Cassisi, Gianniantonio, additional, and Batticciotto, Alberto, additional

Published
2021
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27. Diagnostic and therapeutic care pathway for fibromyalgia

Author

Sarzi-Puttini, Piercarlo, primary, Giorgi, Valeria, additional, Atzeni, Fabiola, additional, Gorla, Roberto, additional, Kosek, Eva, additional, Choy, Ernest H., additional, Bazzichi, Laura, additional, Häuser, Winfred, additional, Ablin, Jacob N., additional, Aloush, Valerie, additional, Buskila, Dan, additional, Amital, Howard, additional, Da Silva, Jose A.P., additional, Perrot, Serge, additional, Morlion, Bart, additional, Polati, Enrico, additional, Schweiger, Vittorio, additional, Coaccioli, Stefano, additional, Varrassi, Giustino, additional, Di Franco, Manuela, additional, Torta, Riccardo, additional, Øien Forseth, Karin Maria, additional, Mannerkorpi, Kaisa, additional, Salaffi, Fausto, additional, Di Carlo, Marco, additional, Cassisi, Gianniantonio, additional, and Batticciotto, Alberto, additional

Published
2021
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28. The effect of novel coronavirus disease-2019 (COVID-19) on fibromyalgia syndrome

Author

Salaffi, Fausto, primary, Giorgi, Valeria, additional, Sirotti, Silvia, additional, Bongiovanni, Sara, additional, Farah, Sonia, additional, Bazzichi, Laura, additional, Marotto, Daniela, additional, Atzeni, Fabiola, additional, Rizzi, Maurizio, additional, Batticciotto, Alberto, additional, Lombardi, Giovanni, additional, Galli, Massimo, additional, and Sarzi-Puttini, Piercarlo, additional

Published
2021
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29. Fibromyalgia severity according to age categories: results of a cross-sectional study from a large national database

Author

Di Carlo, Marco, primary, Farah, Sonia, additional, Bazzichi, Laura, additional, Atzeni, Fabiola, additional, Govoni, Marcello, additional, Biasi, Giovanni, additional, Di Franco, Manuela, additional, Mozzani, Flavio, additional, Gremese, Elisa, additional, Dagna, Lorenzo, additional, Batticciotto, Alberto, additional, Fischetti, Fabio, additional, Giacomelli, Roberto, additional, Guiducci, Serena, additional, Guggino, Giuliana, additional, Bentivegna, Mario, additional, Gerli, Roberto, additional, Salvarani, Carlo, additional, Bajocchi, Gianluigi, additional, Ghini, Marco, additional, Iannone, Florenzo, additional, Giorgi, Valeria, additional, Cirillo, Mariateresa, additional, Bonazza, Sara, additional, Barbagli, Stefano, additional, Gioia, Chiara, additional, Marino, Noemi Giuliana, additional, Capacci, Annunziata, additional, Cavalli, Giulio, additional, Cappelli, Antonella, additional, Carubbi, Francesco, additional, Nacci, Francesca, additional, Riccucci, Ilenia, additional, Cutolo, Maurizio, additional, Sinigaglia, Luigi, additional, Sarzi-Puttini, Piercarlo, additional, and Salaffi, Fausto, additional

Published
2021
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30. The role of IL-6 and IL-6 blockade in COVID-19

Author

Potere, Nicola, primary, Batticciotto, Alberto, additional, Vecchié, Alessandra, additional, Porreca, Ettore, additional, Cappelli, Antonella, additional, Abbate, Antonio, additional, Dentali, Francesco, additional, and Bonaventura, Aldo, additional

Published
2021
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31. Use of rituximab in a multicentre cohort of patients with rheumatic diseases during the outbreak of novel SARS-COV-2 infection

Author

Batticciotto, Alberto, primary, Marotto, Daniela, additional, Giorgi, Valeria, additional, Balzarini, Patrizia, additional, Favalli, Ennio Giulio, additional, Balduzzi, Silvia, additional, Fredi, Micaela, additional, Bazzani, Chiara, additional, Sartorelli, Silvia, additional, Ravagnani, Viviana, additional, Tamanini, Silvia, additional, Castelnovo, Laura, additional, Lurati, Alfredo Maria, additional, Farah, Sonia, additional, Bongiovanni, Sara, additional, Caporali, Roberto, additional, Dagna, Lorenzo, additional, Faggioli, Paola, additional, Franceschini, Franco, additional, Montecucco, Carlo Maurizio, additional, Salaffi, Fausto, additional, Galli, Massimo, additional, Cappelli, Antonella, additional, and Sarzi-Puttini, Piercarlo, additional

Published
2021
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32. Dynamic Contrast-Enhanced MRI Confirms Rapid And Sustained Improvement Of Rheumatoid Arthritis Induced By Tocilizumab Treatment: An Italian Multicentre Study

Author

Cimmino,Marco A, Parodi,Massimiliano, Barbieri,Francesca, Bombardieri,Stefano, Zampogna,Giuseppe, Iagnocco,Annamaria, Batticciotto,Alberto, Sconfienza,Luca M, Sinigaglia,Luigi, De Benedetti,Fabrizio, Atzeni,Fabiola, Sarzi-Puttini,Piercarlo, Cimmino,Marco A, Parodi,Massimiliano, Barbieri,Francesca, Bombardieri,Stefano, Zampogna,Giuseppe, Iagnocco,Annamaria, Batticciotto,Alberto, Sconfienza,Luca M, Sinigaglia,Luigi, De Benedetti,Fabrizio, Atzeni,Fabiola, and Sarzi-Puttini,Piercarlo

Abstract

Marco A Cimmino,1 Massimiliano Parodi,1 Francesca Barbieri,1 Stefano Bombardieri,2 Giuseppe Zampogna,1 Annamaria Iagnocco,3 Alberto Batticciotto,4 Luca Maria Sconfienza,5,6 Luigi Sinigaglia,7 Fabrizio De Benedetti,8 Fabiola Atzeni,9 Piercarlo Sarzi-Puttini10 1Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, Genoa, Italy; 2Rheumatology Unit, Santa Chiara Hospital, University of Pisa, Pisa, Italy; 3Academic Rheumatology Centre, Università degli Studi di Torino, Turin, Italy; 4Rheumatology Unit ASST-Settelaghi, Ospedale di Circolo – Fondazione Macchi, Varese, Varese, Italy; 5IRCCS Istituto Ortopedico Galeazzi, Milan, Italy; 6Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Milan, Italy; 7Rheumatology Unit, G. Pini Hospital, Milan, Italy; 8Division of Rheumatology, IRCCS, Bambin Gesù Paediatric Hospital, Rome, Italy; 9Rheumatology Unit, University of Messina, Messina, Italy; 10Rheumatology Unit, L. Sacco University Hospital, Milan, ItalyCorrespondence: Piercarlo Sarzi-PuttiniReumatology Department, L. Sacco University Hospital, ASST Fatebenefratelli – Sacco, Via G.B. Grassi, 74, Milan 20157, ItalyTel +39 02 39042208Email piercarlo.sarziputtini@gmail.comObjective: This open-label study evaluated the effects of combined tocilizumab (TCZ) and disease-modifying antirheumatic drugs (DMARDs) on magnetic resonance imaging (MRI) changes in synovial membrane enhancement, bone marrow edema (BME), and erosions in the wrist and hand joints of rheumatoid arthritis (RA) patients inadequately responding to DMARDs alone.Methods: The efficacy of intravenous TCZ 8 mg/kg administered every four weeks for 48 weeks was evaluated on six occasions. The primary endpoints were the changes in the extent and degree of wrist synovitis as measured using the RA MRI Score (RAMRIS) and dynamic, gadolinium-enhanced 0.2T MRI (DCE-MRI). A number

Published
2020

33. Diffuse idiopathic skeletal hyperostosis: a review

Author

Mader, Reuven, primary, Marotto, Daniela, additional, Batticciotto, Alberto, additional, Filippou, Georgios, additional, Bieber, Amir, additional, Novofastovski, Irina, additional, Giorgi, Valeria, additional, Carotti, Marina, additional, Salaffi, Fausto, additional, and Sarzi Puttini, Piercarlo, additional

Published
2021
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34. Prevalence of COVID infections in a population of rheumatic patients from Lombardy and Marche treated with biological drugs or small molecules: A multicentre retrospective study

Author

Sarzi-Puttini, Piercarlo, primary, Marotto, Daniela, additional, Caporali, Roberto, additional, Montecucco, Carlo Maurizio, additional, Favalli, Ennio Giulio, additional, Franceschini, Franco, additional, Fredi, Michela, additional, Balduzzi, Silvia, additional, Bazzani, Chiara, additional, Bongiovanni, Sara, additional, Giorgi, Valeria, additional, Batticciotto, Alberto, additional, Cappelli, Antonella, additional, Balzarini, Patrizia, additional, Dagna, Lorenzo, additional, Sartorelli, Silvia, additional, Ravagnani, Viviana, additional, Tamanini, Silvia, additional, Farah, Sonia, additional, Faggioli, Paola, additional, Castelnovo, Laura, additional, Lurati, Alfredo Maria, additional, Galli, Massimo, additional, and Salaffi, Fausto, additional

Published
2021
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35. The association between body mass index and fibromyalgia severity: data from a cross-sectional survey of 2339 patients

Author

Atzeni, Fabiola, primary, Alciati, Alessandra, additional, Salaffi, Fausto, additional, Di Carlo, Marco, additional, Bazzichi, Laura, additional, Govoni, Marcello, additional, Biasi, Giovanni, additional, Di Franco, Manuela, additional, Mozzani, Flavio, additional, Gremese, Elisa, additional, Dagna, Lorenzo, additional, Batticciotto, Alberto, additional, Fischetti, Fabio, additional, Giacomelli, Roberto, additional, Guiducci, Serena, additional, Guggino, Giuliana, additional, Bentivegna, Mario, additional, Gerli, Roberto, additional, Salvarani, Carlo, additional, Bajocchi, Gianluigi, additional, Ghini, Marco, additional, Iannone, Florenzo, additional, Giorgi, Valeria, additional, Farah, Sonia, additional, Bonazza, Sara, additional, Barbagli, Stefano, additional, Gioia, Chiara, additional, Marino, Noemi Giuliana, additional, Capacci, Annunziata, additional, Cavalli, Giulio, additional, Cappelli, Antonella, additional, Carubbi, Francesco, additional, Nacci, Francesca, additional, Riccucci, Ilenia, additional, Cutolo, Maurizio, additional, Sinigaglia, Luigi, additional, and Sarzi-Puttini, Piercarlo, additional

Published
2021
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36. Sensitivity to change and clinical correlations of the novel DACtylitis glObal Sonographic (DACTOS) score in psoriatic arthritis

Author

Girolimetto, Nicolò, primary, Zabotti, Alen, additional, Tinazzi, Ilaria, additional, Possemato, Niccolò, additional, Costa, Luisa, additional, Batticciotto, Alberto, additional, Canzoni, Marco, additional, Citriniti, Giorgia, additional, Lucia, Orazio De, additional, Figus, Fabiana, additional, Idolazzi, Luca, additional, McConnel, Rebecca, additional, Peluso, Rosario, additional, Sakellariou, Garifallia, additional, Tullio, Annarita, additional, Salvarani, Carlo, additional, Scarpa, Raffaele, additional, Iagnocco, Annamaria, additional, Caso, Francesco, additional, and Macchioni, Pierluigi, additional

Published
2020
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37. Definition of fibromyalgia severity: findings from a cross-sectional survey of 2339 Italian patients

Author

Salaffi, Fausto, primary, Di Carlo, Marco, additional, Bazzichi, Laura, additional, Atzeni, Fabiola, additional, Govoni, Marcello, additional, Biasi, Giovanni, additional, Di Franco, Manuela, additional, Mozzani, Flavio, additional, Gremese, Elisa, additional, Dagna, Lorenzo, additional, Batticciotto, Alberto, additional, Fischetti, Fabio, additional, Giacomelli, Roberto, additional, Guiducci, Serena, additional, Guggino, Giuliana, additional, Bentivegna, Mario, additional, Gerli, Roberto, additional, Salvarani, Carlo, additional, Bajocchi, Gianluigi, additional, Ghini, Marco, additional, Iannone, Florenzo, additional, Giorgi, Valeria, additional, Farah, Sonia, additional, Cirillo, Mariateresa, additional, Bonazza, Sara, additional, Barbagli, Stefano, additional, Gioia, Chiara, additional, Santilli, Daniele, additional, Capacci, Annunziata, additional, Cavalli, Giulio, additional, Carubbi, Francesco, additional, Nacci, Francesca, additional, Riccucci, Ilenia, additional, Sinigaglia, Luigi, additional, Masullo, Maurizio, additional, Polizzi, Bianca Maria, additional, Cutolo, Maurizio, additional, and Sarzi-Puttini, Piercarlo, additional

Published
2020
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38. Novel and reliable DACTylitis glObal Sonographic (DACTOS) score in psoriatic arthritis

Author

Zabotti, Alen, primary, Sakellariou, Garifallia, additional, Tinazzi, Ilaria, additional, Idolazzi, Luca, additional, Batticciotto, Alberto, additional, Canzoni, Marco, additional, Carrara, Greta, additional, De Lucia, Orazio, additional, Figus, Fabiana, additional, Girolimetto, Nicolò, additional, Macchioni, Pierluigi, additional, McConnell, Rebecca, additional, Possemato, Niccolò, additional, and Iagnocco, Annamaria, additional

Published
2020
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39. Differential Diagnosis of Inflammatory Arthropathies by Musculoskeletal Ultrasonography: A Systematic Literature Review

Author

Sakellariou, Garifallia, primary, Scirè, Carlo Alberto, additional, Adinolfi, Antonella, additional, Batticciotto, Alberto, additional, Bortoluzzi, Alessandra, additional, Delle Sedie, Andrea, additional, De Lucia, Orazio, additional, Dejaco, Christian, additional, Epis, Oscar Massimiliano, additional, Filippucci, Emilio, additional, Idolazzi, Luca, additional, Picchianti Diamanti, Andrea, additional, Zabotti, Alen, additional, Iagnocco, Annamaria, additional, and Filippou, Georgios, additional

Published
2020
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40. Dynamic Contrast-Enhanced MRI Confirms Rapid And Sustained Improvement Of Rheumatoid Arthritis Induced By Tocilizumab Treatment: An Italian Multicentre Study

Author

Cimmino, Marco A, primary, Parodi, Massimiliano, additional, Barbieri, Francesca, additional, Bombardieri, Stefano, additional, Zampogna, Giuseppe, additional, Iagnocco, Annamaria, additional, Batticciotto, Alberto, additional, Sconfienza, Luca M, additional, Sinigaglia, Luigi, additional, De Benedetti, Fabrizio, additional, Atzeni, Fabiola, additional, and Sarzi-Puttini, Piercarlo, additional

Published
2020
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41. Timing of onset affects arthritis presentation pattern in antisyntethase syndrome

Author

González Gay, Miguel A., Montecucco, Carlomaurizio, Selva O Callaghan, Albert, Trallero Araguas, Ernesto, Molberg, Ovynd, Andersson, Helena, Rojas Serrano, Jorge, Perez Roman, Diana Isabel, Bauhammer, Jutta, Fiehn, Christoph, Neri, Rossella, Barsotti, Simone, Lorenz, Hannes M., Andrea Doria, anna ghirardello, Iannone, Florenzo, Giannini, Margherita, Franceschini, Franco, Cavazzana, Ilaria, Triantafyllias, Konstantinos, Benucci, Maurizio, Infantino, Maria, Manfredi, Mariangela, Conti, Fabrizio, Schwarting, Andreas, Sebastiani, Giandomenico, Iuliano, Annamaria, Emmi, Giacomo, Silvestri, Elena, Govoni, Marcello, Scirè, Carlo Alberto, Furini, Federica, Lopez Longo, Francisco Javier, Martínez Barrio, Julia, Sebastiani, Marco, Manfredi, Andreina, Bachiller Corral, Javier, Sifuentes Giraldo, Walter Alberto, Cimmino, Marco A., Cosso, Claudio, Belotti Masserini, Alessandro, Cagnotto, Giovanni, Codullo, Veronica, Romano, Mariaeva, Paolazzi, Giuseppe, Pellerito, Raffaele, Saketkoo, Lesley Ann, Ortego Centeno, Norberto, Quartuccio, Luca, Batticciotto, Alberto, Bartoloni Bocci, Elena, Gerli, Roberto, Specker, Christof, Bravi, Elena, Selmi, Carlo, Parisi, Simone, Salaffi, Fausto, Meloni, Federica, Marchioni, Enrico, Pesci, Alberto, Dei, Giulia, Confalonieri, Marco, Tomietto, Paola, Nuno, Laura, Bonella, Francesco, Pipitone, Nicolò, Mera Valera, Antonio, Perez Gomez, Nair, Gerzeli, Simone, Lopez Mejias, Raquel, Matos Costa, Carlo Jorge, Pereira Da Silva, Jose Antonio, Cifrian, José, Alpini, Claudia, Olivieri, Ignazio, Blázquez Cañamero, María Ángeles, Rodriguez Cambrón, Ana Belén, Castañeda, Santos, Cavagna, Lorenzo, González-Gay, M, Montecucco, C, Selva-O'Callaghan, A, Trallero-Araguas, E, Molberg, O, Andersson, H, Rojas-Serrano, J, Perez-Roman, D, Bauhammer, J, Fiehn, C, Neri, R, Barsotti, S, Lorenz, H, Doria, A, Ghirardello, A, Iannone, F, Giannini, M, Franceschini, F, Cavazzana, I, Triantafyllias, K, Benucci, M, Infantino, M, Manfredi, M, Conti, F, Schwarting, A, Sebastiani, G, Iuliano, A, Emmi, G, Silvestri, E, Govoni, M, Scirè, C, Furini, F, Lopez-Longo, F, Martínez-Barrio, J, Sebastiani, M, Manfredi, A, Bachiller-Corral, J, Sifuentes Giraldo, W, Cimmino, M, Cosso, C, Belotti Masserini, A, Cagnotto, G, Codullo, V, Romano, M, Paolazzi, G, Pellerito, R, Saketkoo, L, Ortego-Centeno, N, Quartuccio, L, Batticciotto, A, Bartoloni Bocci, E, Gerli, R, Specker, C, Bravi, E, Selmi, C, Parisi, S, Salaffi, F, Meloni, F, Marchioni, E, Pesci, A, Dei, G, Confalonieri, M, Tomietto, P, Nuno, L, Bonella, F, Pipitone, N, Mera-Valera, A, Perez-Gomez, N, Gerzeli, S, Lopez-Mejias, R, Matos-Costa, C, Pereira da Silva, J, Cifrian, J, Alpini, C, Olivieri, I, Blázquez Cañamero, M, Rodriguez Cambrón, A, Castañeda, S, Cavagna, L, González-Gay, Miguel A, Montecucco, Carlomaurizio, Selva-O'Callaghan, Albert, Trallero-Araguas, Ernesto, Molberg, Ovynd, Andersson, Helena, Rojas-Serrano, Jorge, Perez-Roman, Diana Isabel, Bauhammer, Jutta, Fiehn, Christoph, Neri, Rossella, Barsotti, Simone, Lorenz, Hannes M, Doria, Andrea, Ghirardello, Anna, Iannone, Florenzo, Giannini, Margherita, Franceschini, Franco, Cavazzana, Ilaria, Triantafyllias, Konstantino, Benucci, Maurizio, Infantino, Maria, Manfredi, Mariangela, Conti, Fabrizio, Schwarting, Andrea, Sebastiani, Giandomenico, Iuliano, Annamaria, Emmi, Giacomo, Silvestri, Elena, Govoni, Marcello, Scirè, Carlo Alberto, Furini, Federica, Lopez-Longo, Francisco Javier, Martínez-Barrio, Julia, Sebastiani, Marco, Manfredi, Andreina, Bachiller-Corral, Javier, Sifuentes Giraldo, Walter Alberto, Cimmino, Marco A, Cosso, Claudio, Belotti Masserini, Alessandro, Cagnotto, Giovanni, Codullo, Veronica, Romano, Mariaeva, Paolazzi, Giuseppe, Pellerito, Raffaele, Saketkoo, Lesley Ann, Ortego-Centeno, Norberto, Quartuccio, Luca, Batticciotto, Alberto, Bartoloni Bocci, Elena, Gerli, Roberto, Specker, Christof, Bravi, Elena, Selmi, Carlo, Parisi, Simone, Salaffi, Fausto, Meloni, Federica, Marchioni, Enrico, Pesci, Alberto, Dei, Giulia, Confalonieri, Marco, Tomietto, Paola, Nuno, Laura, Bonella, Francesco, Pipitone, Nicolò, Mera-Valera, Antonio, Perez-Gomez, Nair, Gerzeli, Simone, Lopez-Mejias, Raquel, Matos-Costa, Carlo Jorge, Pereira da Silva, Jose Antonio, Cifrian, José, Alpini, Claudia, Olivieri, Ignazio, Blázquez Cañamero, María Ángele, Rodriguez Cambrón, Ana Belén, Castañeda, Santo, and Cavagna, Lorenzo

Subjects
Adult, Male, Time Factors, phenotype, autoantibodies, prevalence, Medizin, Antisynthetase syndrome, Arthritis pattern, Timing of onset, Arthritis, Autoantibodies, Biomarkers, Europe, Female, Humans, Mexico, Middle Aged, Myositis, Phenotype, Prevalence, Prognosis, Retrospective Studies, Risk Factors, NO, antisynthetase syndrome, arthritis, pulmonary disease, male, middle aged, risk factors, humans, adult, biomarkers, timefFactors, arthriti, retrospective studies, female, arthritis, antisyntethase syndrome, prognosis, myositis
Abstract

Objective To evaluate if the timing of appearance with respect to disease onset may influence the arthritis presentation pattern in antisynthetase syndrome (ASSD). Methods The patients were selected from a retrospective large international cohort of ASSD patients regularly followed-up in centres referring to AENEAS collaborative group. Patients were eligible if they had an antisynthetase antibody testing positive in at least two determinations along with arthritis occurring either at ASSD onset (Group 1) or during the course of the disease (Group 2). Results 445 (70%; 334 females, 110 males, 1 transsexual) out of the 636 ASSD we collected had arthritis, in the majority of cases (367, 83%) from disease onset (Group 1). Patients belonging to Group 1 with respect to Group 2 had an arthritis more commonly polyarticular and symmetrical (p=0.015), IgM-Rheumatoid factor positive (p=0.035), erosions at hands and feet plain x-rays (p=0.036) and more commonly satisfying the 1987 revised classification criteria for rheumatoid arthritis (RA) (p=0.004). Features such as Raynaud's phenomenon, mechanic's hands and fever (e.g. accompanying findings) were more frequently reported in Group 2 (p=0.005). Conclusion In ASSD, the timing of appearance with respect to disease onset influences arthritis characteristics. In particular, RA features are more common when arthritis occurs from ASSD onset, suggesting an overlap between RA and ASSD in these patients. When arthritis appears during the follow-up, it is very close to a connective tissue disease-related arthritis. Also, the different prevalence of accompanying features between these two groups is in line with this possibility

Published
2018

42. Sensitivity to change and clinical correlations of the novel DACtylitis glObal Sonographic (DACTOS) score in psoriatic arthritis.

Author

Girolimetto, Nicolò, Zabotti, Alen, Tinazzi, Ilaria, Possemato, Niccolò, Costa, Luisa, Batticciotto, Alberto, Canzoni, Marco, Citriniti, Giorgia, Lucia, Orazio De, Figus, Fabiana, Idolazzi, Luca, McConnel, Rebecca, Peluso, Rosario, Sakellariou, Garifallia, Tullio, Annarita, Salvarani, Carlo, Scarpa, Raffaele, Iagnocco, Annamaria, Caso, Francesco, and Macchioni, Pierluigi

Subjects
PSORIATIC arthritis, RESEARCH, FINGERS, SCIENTIFIC observation, CONFIDENCE intervals, RESEARCH methodology evaluation, MEDICAL cooperation, DESCRIPTIVE statistics, LONGITUDINAL method
Abstract

Objective The aim of the study is to assess the performance of the DACTOS (DACtylitis glObal Sonographic) score in a PsA dactylitis clinical setting. In particular, we evaluated the ability of DACTOS to identify the affected fingers, its sensitivity to change after treatment, the correlations between DACTOS and clinical parameters, and the capacity of the score to identify the treatment responders. Methods Forty-six consecutive patients with symptomatic PsA hand dactylitis were enrolled. A total of seventy-three dactylitic digits were evaluated clinically and sonographically before and after treatment in this observational and prospective study. Clinical assessment included the Leeds Dactylitis Index-basic (LDI-b) score and visual analogue scales for pain (VAS-p) and functional impairment (VAS - FI). Sonographic lesions were investigated using high-frequency ultrasound with grey scale and power Doppler features according to the DACTOS score. Correlations between the DACTOS score and the clinical parameters were assessed at baseline, 1 month (T1) and 3 months (T3). Results We observed significant improvements in all of the assessed clinical parameters and the DACTOS scores after dactylitis treatment. There was a statistically significant correlation between the variation of all clinical parameters (VAS-p, VAS-FI and LDI-b) and the DACTOS score at T1 and T3 evaluations. We found statistically significant differences in the DACTOS score between clinical responder and non-responder groups (P  < 0.001) and between clinical remission and non-remission groups (P  < 0.001). Conclusion The DACTOS score performs well in real-life clinical settings in terms of sensitivity to change and correlations with clinical features in PsA dactylitis. [ABSTRACT FROM AUTHOR]

Published
2021
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43. Hyperbaric oxygen treatment of fibromyalgia: a prospective observational clinical study

Author

Atzeni, Fabiola, Casale, Roberto, Alciati, Alessandra, Masala, Ignazio Francesco, Batticciotto, Alberto, Talotta, Rossella, Gerardi, Maria Chiara, Salaffi, Fausto, and Sarzi-Puttini, Piercarlo

Subjects
Oxygen, Hyperbaric Oxygenation, Fibromyalgia, Treatment Outcome, Humans, Prospective Studies, Quality of Life
Abstract

Fibromyalgia (FM) is a syndrome of unknown aetiology that is characterised by widespread musculoskeletal pain, fatigue and disordered sleep, and often associated with neuropsychiatric and cognitive symptoms. Current treatment options are only partially effective, but hyperbaric oxygen therapy (HBOT) seems to be capable of relieving some of the symptoms. The aim of this study was to evaluate the efficacy and safety of HBOT after fewer sessions than generally used, chosen on the basis of pre-clinical and clinical data showing its rapid and sustained antinociceptive effect.Patients with FM underwent HBOT (100% oxygen at 2.5 ata with air breaks) administered on three days per week for a total of twenty 90-minute sessions. Pain, fatigue, the quality of sleep, symptoms of anxiety and depression, and the patients' health-related quality of life were prospectively assessed before and after ten and twenty sessions.Twenty-eight of the 32 study patients completed the 20 HBOT sessions. Pain scores and the symptoms of anxiety (but not those of depression) significantly improved after both 10 and 20 sessions, whereas fatigue and FM symptom severity scores significantly improved only after 20 sessions. There was no significant change in the quality of sleep. The adverse effects were limited.These findings support the view that HBOT is an effective, rapid and safe means of treating various symptoms of FM.

Published
2018

44. Medical cannabis and cannabinoids in rheumatology: where are we now?

Author

Sarzi-Puttini, Piercarlo, primary, Batticciotto, Alberto, additional, Atzeni, Fabiola, additional, Bazzichi, Laura, additional, Di Franco, Manuela, additional, Salaffi, Fausto, additional, Marotto, Daniela, additional, Ceribelli, Angela, additional, Ablin, Jacob N, additional, and Hauser, Winfred, additional

Published
2019
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45. Transition phase towards psoriatic arthritis: clinical and ultrasonographic characterisation of psoriatic arthralgia

Author

Zabotti, Alen, primary, McGonagle, Dennis G, additional, Giovannini, Ivan, additional, Errichetti, Enzo, additional, Zuliani, Francesca, additional, Zanetti, Anna, additional, Tinazzi, Ilaria, additional, De Lucia, Orazio, additional, Batticciotto, Alberto, additional, Idolazzi, Luca, additional, Sakellariou, Garifallia, additional, Zandonella Callegher, Sara, additional, Sacco, Stefania, additional, Quartuccio, Luca, additional, Iagnocco, Annamaria, additional, and De Vita, Salvatore, additional

Published
2019
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47. SAT0656 DAPSA OR MDA/VLDA CRITERIA FOR DEFINING THE TREATMENT TARGET IN PSORIATIC ARTHRITIS? CROSS-SECTIONAL ANALYSIS FROM A MULTICENTER ITALIAN COHORT

Author

Favalli, Ennio Giulio, primary, Idolazzi, Luca, additional, Bugatti, Serena, additional, Batticciotto, Alberto, additional, Quartuccio, Luca, additional, Filippini, Matteo, additional, Parisi, Simone, additional, Biggioggero, Martina, additional, Fassio, Angelo, additional, Zanframundo, G, additional, Guggino, Giuliana, additional, Giovannini, I, additional, Ditto, Maria Chiara, additional, and Ciccia, Francesco, additional

Published
2019
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49. Timing of onset affects arthritis presentation pattern in antisyntethase syndrome

Author

González-Gay, M, Montecucco, C, Selva-O'Callaghan, A, Trallero-Araguas, E, Molberg, O, Andersson, H, Rojas-Serrano, J, Perez-Roman, D, Bauhammer, J, Fiehn, C, Neri, R, Barsotti, S, Lorenz, H, Doria, A, Ghirardello, A, Iannone, F, Giannini, M, Franceschini, F, Cavazzana, I, Triantafyllias, K, Benucci, M, Infantino, M, Manfredi, M, Conti, F, Schwarting, A, Sebastiani, G, Iuliano, A, Emmi, G, Silvestri, E, Govoni, M, Scirè, C, Furini, F, Lopez-Longo, F, Martínez-Barrio, J, Sebastiani, M, Manfredi, A, Bachiller-Corral, J, Sifuentes Giraldo, W, Cimmino, M, Cosso, C, Belotti Masserini, A, Cagnotto, G, Codullo, V, Romano, M, Paolazzi, G, Pellerito, R, Saketkoo, L, Ortego-Centeno, N, Quartuccio, L, Batticciotto, A, Bartoloni Bocci, E, Gerli, R, Specker, C, Bravi, E, Selmi, C, Parisi, S, Salaffi, F, Meloni, F, Marchioni, E, Pesci, A, Dei, G, Confalonieri, M, Tomietto, P, Nuno, L, Bonella, F, Pipitone, N, Mera-Valera, A, Perez-Gomez, N, Gerzeli, S, Lopez-Mejias, R, Matos-Costa, C, Pereira da Silva, J, Cifrian, J, Alpini, C, Olivieri, I, Blázquez Cañamero, M, Rodriguez Cambrón, A, Castañeda, S, Cavagna, L, González-Gay, Miguel A, Montecucco, Carlomaurizio, Selva-O'Callaghan, Albert, Trallero-Araguas, Ernesto, Molberg, Ovynd, Andersson, Helena, Rojas-Serrano, Jorge, Perez-Roman, Diana Isabel, Bauhammer, Jutta, Fiehn, Christoph, Neri, Rossella, Barsotti, Simone, Lorenz, Hannes M, Doria, Andrea, Ghirardello, Anna, Iannone, Florenzo, Giannini, Margherita, Franceschini, Franco, Cavazzana, Ilaria, Triantafyllias, Konstantinos, Benucci, Maurizio, Infantino, Maria, Manfredi, Mariangela, Conti, Fabrizio, Schwarting, Andreas, Sebastiani, Giandomenico, Iuliano, Annamaria, Emmi, Giacomo, Silvestri, Elena, Govoni, Marcello, Scirè, Carlo Alberto, Furini, Federica, Lopez-Longo, Francisco Javier, Martínez-Barrio, Julia, Sebastiani, Marco, Manfredi, Andreina, Bachiller-Corral, Javier, Sifuentes Giraldo, Walter Alberto, Cimmino, Marco A, Cosso, Claudio, Belotti Masserini, Alessandro, Cagnotto, Giovanni, Codullo, Veronica, Romano, Mariaeva, Paolazzi, Giuseppe, Pellerito, Raffaele, Saketkoo, Lesley Ann, Ortego-Centeno, Norberto, Quartuccio, Luca, Batticciotto, Alberto, Bartoloni Bocci, Elena, Gerli, Roberto, Specker, Christof, Bravi, Elena, Selmi, Carlo, Parisi, Simone, Salaffi, Fausto, Meloni, Federica, Marchioni, Enrico, Pesci, Alberto, Dei, Giulia, Confalonieri, Marco, Tomietto, Paola, Nuno, Laura, Bonella, Francesco, Pipitone, Nicolò, Mera-Valera, Antonio, Perez-Gomez, Nair, Gerzeli, Simone, Lopez-Mejias, Raquel, Matos-Costa, Carlo Jorge, Pereira da Silva, Jose Antonio, Cifrian, José, Alpini, Claudia, Olivieri, Ignazio, Blázquez Cañamero, María Ángeles, Rodriguez Cambrón, Ana Belén, Castañeda, Santos, Cavagna, Lorenzo, González-Gay, M, Montecucco, C, Selva-O'Callaghan, A, Trallero-Araguas, E, Molberg, O, Andersson, H, Rojas-Serrano, J, Perez-Roman, D, Bauhammer, J, Fiehn, C, Neri, R, Barsotti, S, Lorenz, H, Doria, A, Ghirardello, A, Iannone, F, Giannini, M, Franceschini, F, Cavazzana, I, Triantafyllias, K, Benucci, M, Infantino, M, Manfredi, M, Conti, F, Schwarting, A, Sebastiani, G, Iuliano, A, Emmi, G, Silvestri, E, Govoni, M, Scirè, C, Furini, F, Lopez-Longo, F, Martínez-Barrio, J, Sebastiani, M, Manfredi, A, Bachiller-Corral, J, Sifuentes Giraldo, W, Cimmino, M, Cosso, C, Belotti Masserini, A, Cagnotto, G, Codullo, V, Romano, M, Paolazzi, G, Pellerito, R, Saketkoo, L, Ortego-Centeno, N, Quartuccio, L, Batticciotto, A, Bartoloni Bocci, E, Gerli, R, Specker, C, Bravi, E, Selmi, C, Parisi, S, Salaffi, F, Meloni, F, Marchioni, E, Pesci, A, Dei, G, Confalonieri, M, Tomietto, P, Nuno, L, Bonella, F, Pipitone, N, Mera-Valera, A, Perez-Gomez, N, Gerzeli, S, Lopez-Mejias, R, Matos-Costa, C, Pereira da Silva, J, Cifrian, J, Alpini, C, Olivieri, I, Blázquez Cañamero, M, Rodriguez Cambrón, A, Castañeda, S, Cavagna, L, González-Gay, Miguel A, Montecucco, Carlomaurizio, Selva-O'Callaghan, Albert, Trallero-Araguas, Ernesto, Molberg, Ovynd, Andersson, Helena, Rojas-Serrano, Jorge, Perez-Roman, Diana Isabel, Bauhammer, Jutta, Fiehn, Christoph, Neri, Rossella, Barsotti, Simone, Lorenz, Hannes M, Doria, Andrea, Ghirardello, Anna, Iannone, Florenzo, Giannini, Margherita, Franceschini, Franco, Cavazzana, Ilaria, Triantafyllias, Konstantinos, Benucci, Maurizio, Infantino, Maria, Manfredi, Mariangela, Conti, Fabrizio, Schwarting, Andreas, Sebastiani, Giandomenico, Iuliano, Annamaria, Emmi, Giacomo, Silvestri, Elena, Govoni, Marcello, Scirè, Carlo Alberto, Furini, Federica, Lopez-Longo, Francisco Javier, Martínez-Barrio, Julia, Sebastiani, Marco, Manfredi, Andreina, Bachiller-Corral, Javier, Sifuentes Giraldo, Walter Alberto, Cimmino, Marco A, Cosso, Claudio, Belotti Masserini, Alessandro, Cagnotto, Giovanni, Codullo, Veronica, Romano, Mariaeva, Paolazzi, Giuseppe, Pellerito, Raffaele, Saketkoo, Lesley Ann, Ortego-Centeno, Norberto, Quartuccio, Luca, Batticciotto, Alberto, Bartoloni Bocci, Elena, Gerli, Roberto, Specker, Christof, Bravi, Elena, Selmi, Carlo, Parisi, Simone, Salaffi, Fausto, Meloni, Federica, Marchioni, Enrico, Pesci, Alberto, Dei, Giulia, Confalonieri, Marco, Tomietto, Paola, Nuno, Laura, Bonella, Francesco, Pipitone, Nicolò, Mera-Valera, Antonio, Perez-Gomez, Nair, Gerzeli, Simone, Lopez-Mejias, Raquel, Matos-Costa, Carlo Jorge, Pereira da Silva, Jose Antonio, Cifrian, José, Alpini, Claudia, Olivieri, Ignazio, Blázquez Cañamero, María Ángeles, Rodriguez Cambrón, Ana Belén, Castañeda, Santos, and Cavagna, Lorenzo

Abstract

Objective To evaluate if the timing of appearance with respect to disease onset may influence the arthritis presentation pattern in antisynthetase syndrome (ASSD). Methods The patients were selected from a retrospective large international cohort of ASSD patients regularly followed-up in centres referring to AENEAS collaborative group. Patients were eligible if they had an antisynthetase antibody testing positive in at least two determinations along with arthritis occurring either at ASSD onset (Group 1) or during the course of the disease (Group 2). Results 445 (70%; 334 females, 110 males, 1 transsexual) out of the 636 ASSD we collected had arthritis, in the majority of cases (367, 83%) from disease onset (Group 1). Patients belonging to Group 1 with respect to Group 2 had an arthritis more commonly polyarticular and symmetrical (p=0.015), IgM-Rheumatoid factor positive (p=0.035), erosions at hands and feet plain x-rays (p=0.036) and more commonly satisfying the 1987 revised classification criteria for rheumatoid arthritis (RA) (p=0.004). Features such as Raynaud's phenomenon, mechanic's hands and fever (e.g. accompanying findings) were more frequently reported in Group 2 (p=0.005). Conclusion In ASSD, the timing of appearance with respect to disease onset influences arthritis characteristics. In particular, RA features are more common when arthritis occurs from ASSD onset, suggesting an overlap between RA and ASSD in these patients. When arthritis appears during the follow-up, it is very close to a connective tissue disease-related arthritis. Also, the different prevalence of accompanying features between these two groups is in line with this possibility

Published
2018

50. Definition of fibromyalgia severity: findings from a cross-sectional survey of 2339 Italian patients.

Author

Salaffi, Fausto, Carlo, Marco Di, Bazzichi, Laura, Atzeni, Fabiola, Govoni, Marcello, Biasi, Giovanni, Franco, Manuela Di, Mozzani, Flavio, Gremese, Elisa, Dagna, Lorenzo, Batticciotto, Alberto, Fischetti, Fabio, Giacomelli, Roberto, Guiducci, Serena, Guggino, Giuliana, Bentivegna, Mario, Gerli, Roberto, Salvarani, Carlo, Bajocchi, Gianluigi, and Ghini, Marco

Subjects
FIBROMYALGIA, QUESTIONNAIRES, REFERENCE values, CROSS-sectional method, SEVERITY of illness index, DESCRIPTIVE statistics
Abstract

Objective To establish optimal cut-off values for the scores of the revised Fibromyalgia Impact Questionnaire (FIQR), the modified Fibromialgia Assessment Scale (FAS 2019mod), and the Polysymptomatic Distress Scale (PDS) in order to distinguish five levels of FM disease severity. Methods Consecutive FM patients were evaluated with the three clinimetric indices, and each patient was required to answer the anchor question: 'In general, would you say your health is 1 = very good, 2 = good, 3 = fair, 4 = poor, or 5 = very poor?'—which represented the external criterion. Cut-off points were established through the interquartile reconciliation approach. Results The study sample consisted of 2181 women (93.2%) and 158 men (6.8%), with a mean age of 51.9 (11.5) years, and mean disease duration was 7.3 (6.9) years. The overall median FIQR, FAS 2019 mod and PDS scores (25th–75th percentiles) were respectively 61.16 (41.16–77.00), 27.00 (19.00–32.00) and 19.0 (13.00–24.00). Reconciliation of the mean 75th and 25th percentiles of adjacent categories defined the severity states for FIQR: 0–23 for remission, 24–40 for mild disease, 41–63 for moderate disease, 64–82 for severe disease and >83 for very severe disease; FAS 2019 mod: 0–12 for remission, 13–20 for mild disease, 21–28 for moderate disease, 29–33 for severe disease and >33 for very severe disease; PDS: 0–5 for remission, 6–15 for mild disease, 16–20 for moderate disease, 21–25 for severe disease and >25 for very severe disease. Conclusions Disease severity cut-offs can represent an important improvement in interpreting FM. [ABSTRACT FROM AUTHOR]

Published
2021
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