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Timing of onset affects arthritis presentation pattern in antisyntethase syndrome
- Source :
- Scopus-Elsevier, Università degli Studi di Padova-IRIS, CIÊNCIAVITAE, Publons, CARLOMAURIZIO MONTECUCCO
- Publication Year :
- 2018
-
Abstract
- Objective To evaluate if the timing of appearance with respect to disease onset may influence the arthritis presentation pattern in antisynthetase syndrome (ASSD). Methods The patients were selected from a retrospective large international cohort of ASSD patients regularly followed-up in centres referring to AENEAS collaborative group. Patients were eligible if they had an antisynthetase antibody testing positive in at least two determinations along with arthritis occurring either at ASSD onset (Group 1) or during the course of the disease (Group 2). Results 445 (70%; 334 females, 110 males, 1 transsexual) out of the 636 ASSD we collected had arthritis, in the majority of cases (367, 83%) from disease onset (Group 1). Patients belonging to Group 1 with respect to Group 2 had an arthritis more commonly polyarticular and symmetrical (p=0.015), IgM-Rheumatoid factor positive (p=0.035), erosions at hands and feet plain x-rays (p=0.036) and more commonly satisfying the 1987 revised classification criteria for rheumatoid arthritis (RA) (p=0.004). Features such as Raynaud's phenomenon, mechanic's hands and fever (e.g. accompanying findings) were more frequently reported in Group 2 (p=0.005). Conclusion In ASSD, the timing of appearance with respect to disease onset influences arthritis characteristics. In particular, RA features are more common when arthritis occurs from ASSD onset, suggesting an overlap between RA and ASSD in these patients. When arthritis appears during the follow-up, it is very close to a connective tissue disease-related arthritis. Also, the different prevalence of accompanying features between these two groups is in line with this possibility
- Subjects :
- Adult
Male
Time Factors
phenotype
autoantibodies
prevalence
Medizin
Antisynthetase syndrome
Arthritis pattern
Timing of onset
Arthritis
Autoantibodies
Biomarkers
Europe
Female
Humans
Mexico
Middle Aged
Myositis
Phenotype
Prevalence
Prognosis
Retrospective Studies
Risk Factors
NO
antisynthetase syndrome
arthritis
pulmonary disease
male
middle aged
risk factors
humans
adult
biomarkers
timefFactors
arthriti
retrospective studies
female
arthritis, antisyntethase syndrome
prognosis
myositis
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Scopus-Elsevier, Università degli Studi di Padova-IRIS, CIÊNCIAVITAE, Publons, CARLOMAURIZIO MONTECUCCO
- Accession number :
- edsair.pmid.dedup....71521a5df0c0a96250f128cc3a3ff517