1. Exploring the use of fatty acid ethyl esters as a potential natural solution for the treatment of fish parasitic diseases.
- Author
-
Jawaji A, Goldberg IK, and Zilberg D
- Subjects
- Parasitic Diseases drug therapy, Microalgae, Poecilia parasitology, Bass parasitology, Aquaculture methods, Toxicity Tests, Fatty Acids pharmacology, Fatty Acids therapeutic use, Fish Diseases drug therapy, Fish Diseases parasitology, Antiparasitic Agents pharmacology, Antiparasitic Agents therapeutic use
- Abstract
Alternatives to conventional chemical treatments for parasitic diseases in fish are needed. Microalgal-sourced fatty acid ethyl esters (FAEEs) have shown an antiparasitic effect against Gyrodactylus turnbulli infection in guppies. Here, we tested a range of commercial FAEEs of various carbon chain lengths and unsaturation levels against two fish parasites. Guppies and barramundi infected with G. turnbulli and Trichodina sp., respectively, were used. The most effective FAEE, after excluding those toxic to fish, was ethyl laurate (12:0). For both parasites, the LD50 was 18.75 μM within 250 min of incubation. Ethyl eicosapentaenoate (20:5n3) was the next most effective FAEE against G. turnbulli, and dihomo-γ-linolenic acid ethyl ester (20:3n6) and ethyl α-linolenate (18:3n3) were the next most effective against Trichodina sp. In addition, FAEEs prepared from the microalga Phaeodactylum tricornutum residue, after fucoxanthin extraction, were examined against Trichodina sp. infection in barramundi for the first time. LD85 and LD100 was achieved at 2.5 and 5 μL mL
-1 of the FAEE preparation, respectively. In vivo, immersion of infected barramundi in 1.25 μL mL-1 of this preparation for 24 h reduced infection prevalence from 100% to 53% and was non-toxic to fish., (© 2024 The Author(s). Journal of Fish Diseases published by John Wiley & Sons Ltd.)- Published
- 2024
- Full Text
- View/download PDF