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21 results on '"Baranger, David A.A."'

7. Alcohol milestones and internalizing, externalizing, and executive function: longitudinal and polygenic score associations

Author

Paul, Sarah E., primary, Baranger, David A.A., additional, Johnson, Emma C., additional, Jackson, Joshua J., additional, Gorelik, Aaron J., additional, Miller, Alex P., additional, Hatoum, Alexander S., additional, Thompson, Wesley K., additional, Strube, Michael, additional, Dick, Danielle M., additional, Kamarajan, Chella, additional, Kramer, John R., additional, Plawecki, Martin H., additional, Chan, Grace, additional, Anokhin, Andrey P., additional, Chorlian, David B., additional, Kinreich, Sivan, additional, Meyers, Jacquelyn L., additional, Porjesz, Bernice, additional, Edenberg, Howard J., additional, Agrawal, Arpana, additional, Bucholz, Kathleen K., additional, and Bogdan, Ryan, additional

Published
2024
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10. Associations Between Polygenic Scores for Cognitive and Non-cognitive Factors of Educational Attainment and Measures of Behavior, Psychopathology, and Neuroimaging in the Adolescent Brain Cognitive Development Study

Author

Gorelik, Aaron J., primary, Paul, Sarah E., additional, Miller, Alex P., additional, Baranger, David A.A., additional, Lin, Shuyu, additional, Zhang, Wei, additional, Elsayed, Nourhan M., additional, Modi, Hailey, additional, Addala, Pooja, additional, Bijsterbosch, Janine, additional, Barch, Deanna M., additional, Karcher, Nicole R., additional, Hatoum, Alexander S., additional, Agrawal, Arpana, additional, Bogdan, Ryan, additional, and Johnson, Emma C., additional

Published
2023
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12. Phenome-wide Investigation of Behavioral, Environmental, and Neural Associations with Cross-Disorder Genetic Liability in Youth of European Ancestry

Author

Paul, Sarah E., primary, Colbert, Sarah M.C., additional, Gorelik, Aaron J., additional, Hansen, Isabella S., additional, Nagella, I., additional, Blaydon, L., additional, Hornstein, A., additional, Johnson, Emma C., additional, Hatoum, Alexander S., additional, Baranger, David A.A., additional, Elsayed, Nourhan M., additional, Barch, Deanna M., additional, Bogdan, Ryan, additional, and Karcher, Nicole R., additional

Published
2023
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15. DISC1 and SLC12A2 interaction affects human hippocampal function and connectivity

Author

Callicott, Joseph H., Feighery, Emer L., Mattay, Venkata S., White, Michael G., Chen, Qiang, Baranger, David A.A., Berman, Karen F., Lu, Bai, Song, Hongjun, Ming, Guo-li, and Weinberger, Daniel R.

Subjects
Physiological aspects, Genetic aspects, Research, GABA -- Physiological aspects, Developmental neurophysiology -- Research, Parahippocampal region -- Physiological aspects -- Genetic aspects, Neurochemistry -- Research, Schizophrenia -- Genetic aspects
Abstract

Hippocampal development is coordinated by both extracellular factors like GABA neurotransmission and intracellular components like DISC1. We previously reported that SLC12A2-dependent GABA depolarization and DISC1 coregulate hippocampal neuronal development, and [...]

Published
2013
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18. A large-scale genome-wide association study meta-analysis of cannabis use disorder

Author

Johnson, Emma C., Demontis, Ditte, Thorgeirsson, Thorgeir E., Walters, Raymond K., Polimanti, Renato, Hatoum, Alexander S., Sanchez-Roige, Sandra, Paul, Sarah E., Wendt, Frank R., Clarke, Toni Kim, Lai, Dongbing, Reginsson, Gunnar W., Zhou, Hang, He, June, Baranger, David A.A., Gudbjartsson, Daniel F., Wedow, Robbee, Adkins, Daniel E., Adkins, Amy E., Alexander, Jeffry, Bacanu, Silviu Alin, Bigdeli, Tim B., Boden, Joseph, Brown, Sandra A., Bucholz, Kathleen K., Bybjerg-Grauholm, Jonas, Corley, Robin P., Degenhardt, Louisa, Dick, Danielle M., Domingue, Benjamin W., Fox, Louis, Goate, Alison M., Gordon, Scott D., Hack, Laura M., Hancock, Dana B., Hartz, Sarah M., Hickie, Ian B., Hougaard, David M., Krauter, Kenneth, Lind, Penelope A., McClintick, Jeanette N., McQueen, Matthew B., Meyers, Jacquelyn L., Montgomery, Grant W., Mors, Ole, Mortensen, Preben B., Nordentoft, Merete, Pearson, John F., Peterson, Roseann E., Werge, Thomas, Johnson, Emma C., Demontis, Ditte, Thorgeirsson, Thorgeir E., Walters, Raymond K., Polimanti, Renato, Hatoum, Alexander S., Sanchez-Roige, Sandra, Paul, Sarah E., Wendt, Frank R., Clarke, Toni Kim, Lai, Dongbing, Reginsson, Gunnar W., Zhou, Hang, He, June, Baranger, David A.A., Gudbjartsson, Daniel F., Wedow, Robbee, Adkins, Daniel E., Adkins, Amy E., Alexander, Jeffry, Bacanu, Silviu Alin, Bigdeli, Tim B., Boden, Joseph, Brown, Sandra A., Bucholz, Kathleen K., Bybjerg-Grauholm, Jonas, Corley, Robin P., Degenhardt, Louisa, Dick, Danielle M., Domingue, Benjamin W., Fox, Louis, Goate, Alison M., Gordon, Scott D., Hack, Laura M., Hancock, Dana B., Hartz, Sarah M., Hickie, Ian B., Hougaard, David M., Krauter, Kenneth, Lind, Penelope A., McClintick, Jeanette N., McQueen, Matthew B., Meyers, Jacquelyn L., Montgomery, Grant W., Mors, Ole, Mortensen, Preben B., Nordentoft, Merete, Pearson, John F., Peterson, Roseann E., and Werge, Thomas

Abstract

Background: Variation in liability to cannabis use disorder has a strong genetic component (estimated twin and family heritability about 50–70%) and is associated with negative outcomes, including increased risk of psychopathology. The aim of the study was to conduct a large genome-wide association study (GWAS) to identify novel genetic variants associated with cannabis use disorder. Methods: To conduct this GWAS meta-analysis of cannabis use disorder and identify associations with genetic loci, we used samples from the Psychiatric Genomics Consortium Substance Use Disorders working group, iPSYCH, and deCODE (20 916 case samples, 363 116 control samples in total), contrasting cannabis use disorder cases with controls. To examine the genetic overlap between cannabis use disorder and 22 traits of interest (chosen because of previously published phenotypic correlations [eg, psychiatric disorders] or hypothesised associations [eg, chronotype] with cannabis use disorder), we used linkage disequilibrium score regression to calculate genetic correlations. Findings: We identified two genome-wide significant loci: a novel chromosome 7 locus (FOXP2, lead single-nucleotide polymorphism [SNP] rs7783012; odds ratio [OR] 1·11, 95% CI 1·07–1·15, p=1·84 × 10−9) and the previously identified chromosome 8 locus (near CHRNA2 and EPHX2, lead SNP rs4732724; OR 0·89, 95% CI 0·86–0·93, p=6·46 × 10−9). Cannabis use disorder and cannabis use were genetically correlated (rg 0·50, p=1·50 × 10−21), but they showed significantly different genetic correlations with 12 of the 22 traits we tested, suggesting at least partially different genetic underpinnings of cannabis use and cannabis use disorder. Cannabis use disorder was positively genetically correlated with other psychopathology, including ADHD, major depression, and schizophrenia. Interpretation: These findings support the theory that cannabis use disorder has shared genetic liability with oth

Published
2020

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