DISC1 and SLC12A2 interaction affects human hippocampal function and connectivity

Authors :: Callicott, Joseph H.
Feighery, Emer L.
Mattay, Venkata S.
White, Michael G.
Chen, Qiang
Baranger, David A.A.
Berman, Karen F.
Lu, Bai
Song, Hongjun
Ming, Guo-li
Weinberger, Daniel R.
Source :: Journal of Clinical Investigation. July 2013, Vol. 123 Issue 7, p2961, 4 p.
Publication Year :: 2013
Abstract: Hippocampal development is coordinated by both extracellular factors like GABA neurotransmission and intracellular components like DISC1. We previously reported that SLC12A2-dependent GABA depolarization and DISC1 coregulate hippocampal neuronal development, and [...]

Subjects :: Physiological aspects
Genetic aspects
Research
GABA -- Physiological aspects
Developmental neurophysiology -- Research
Parahippocampal region -- Physiological aspects -- Genetic aspects
Neurochemistry -- Research
Schizophrenia -- Genetic aspects

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