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Your search keyword '"Bao, Zhihong"' showing total 30 results
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30 results on '"Bao, Zhihong"'

13. Electrochemical evaluation of antioxidant capacity in pharmaceutical antioxidant excipient of drugs on guanine-based modified electrode

Author

Yuan Yue, LI San-ming, Bao Zhihong, and Zhao Kun

Subjects
Antioxidant, Guanine, General Chemical Engineering, medicine.medical_treatment, 010401 analytical chemistry, Inorganic chemistry, technology, industry, and agriculture, Nanoparticle, Excipient, 02 engineering and technology, Sodium metabisulfite, 021001 nanoscience & nanotechnology, Electrochemistry, 01 natural sciences, 0104 chemical sciences, Analytical Chemistry, chemistry.chemical_compound, chemistry, Electrode, medicine, 0210 nano-technology, Biosensor, Nuclear chemistry, medicine.drug
Abstract

The aim of this study is to propose a new electrochemical method for the evaluation of the antioxidant capacity of the pharmaceutical antioxidant excipient in drugs. The evaluation was conducted by integrity testing of DNA bases, which were modified on an electrode. Guanine was selected as the electrochemical probe. Based on the changes of the oxidation current of guanine on a modified glassy carbon electrode (GCE), the protective capacity of the antioxidant for guanine was determined. TiO 2 nanoparticles (TiO 2 NPs) adhering to maltiwalled carbon nanotubes (MWCNTs) were used for guanine oxidation via photo generating hydroxyl radicals. The MWCNTs were used, because of their unique ability to accelerate the electron transfer rate. Using a simple evaporation and drying process, the TiO 2 NPs/MWCNTs, modified material was added to the GCE. In this report, sodium metabisulfite was selected as the object antioxidant for antioxidant capability determination. The detection results in real samples showed that the guanine/TiO 2 NPs/MWCNTs/GCE biosensor is appropriate for evaluating the antioxidant capacity of antioxidants in drugs.

Published
2016

14. Platinum nanoparticle-doped multiwalled carbon-nanotube-modified glassy carbon electrode as a sensor for simultaneous determination of atenolol and propranolol in neutral solution

Author

Bao Zhihong, Chen Hongtao, Yuan Yue, Zhao Kun, LI San-ming, and Lu Fangzheng

Subjects
Horizontal scan rate, Nanotube, Materials science, General Chemical Engineering, General Engineering, General Physics and Astronomy, chemistry.chemical_element, Electrochemistry, Platinum nanoparticles, chemistry, Organic chemistry, General Materials Science, Differential pulse voltammetry, Cyclic voltammetry, Platinum, Chemically modified electrode, Nuclear chemistry
Abstract

In this paper, the simultaneous determination of β-blockers (atenolol (ATN) and propranolol (PRO)) was investigated using cyclic voltammetry (CV) and differential pulse voltammetry (DPV) at platinum nanoparticle-doped multiwalled carbon-nanotube-modified glassy carbon electrode (PtNPs/MWCNTs/GCE) in 0.1 M PBS (pH 7.4) solution. The modifier, PtNP-doped MWCNTs (PtNPs/MWCNTs), was characterized by transmission electron microscopy (TEM) and electrochemical method which showed an excellent character for electrocatalytic oxidization of ATN and PRO. In addition, the experimental parameters such as pH values, the concentration of PtNPs/MWCNTs, and the scan rate were optimized. CV and DPV results show that the β-blockers can be detected selectively and sensitively at modified GCE. Under the optimized condition, the detection limits of ATN and PRO are 1.17 and 0.15 μM (S/N = 3) with the linear ranges of 5.8–116 and 0.2–50 μM, respectively.

Published
2014

30. Plasmonic gold-superparamagnetic hematite heterostructures.

Author

Bao Z, Sun Z, Li Z, Tian L, Ngai T, and Wang J

Subjects
Nanoparticles, Porosity, Solutions, Ferric Compounds chemistry, Gold, Magnetics, Metal Nanoparticles chemistry
Abstract

Bifunctional heterostructures composed of gold nanorods and hematite nanoparticle aggregates are prepared facilely through the hydrothermal decomposition of ferric acetylacetonate on the surface of the nanorods. The gold nanorod in the heterostructure is partially coated with the hematite nanoparticle aggregates. The hematite coating is porous. These heterostructures exhibit both plasmonic and superparamagnetic properties. They are well-dispersed in aqueous solutions. Such heterostructures will be potentially useful for many biotechnological applications., (© 2011 American Chemical Society)

Published
2011
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