Platinum nanoparticle-doped multiwalled carbon-nanotube-modified glassy carbon electrode as a sensor for simultaneous determination of atenolol and propranolol in neutral solution

In this paper, the simultaneous determination of β-blockers (atenolol (ATN) and propranolol (PRO)) was investigated using cyclic voltammetry (CV) and differential pulse voltammetry (DPV) at platinum nanoparticle-doped multiwalled carbon-nanotube-modified glassy carbon electrode (PtNPs/MWCNTs/GCE) in 0.1 M PBS (pH 7.4) solution. The modifier, PtNP-doped MWCNTs (PtNPs/MWCNTs), was characterized by transmission electron microscopy (TEM) and electrochemical method which showed an excellent character for electrocatalytic oxidization of ATN and PRO. In addition, the experimental parameters such as pH values, the concentration of PtNPs/MWCNTs, and the scan rate were optimized. CV and DPV results show that the β-blockers can be detected selectively and sensitively at modified GCE. Under the optimized condition, the detection limits of ATN and PRO are 1.17 and 0.15 μM (S/N = 3) with the linear ranges of 5.8–116 and 0.2–50 μM, respectively.