675 results on '"Ballmer-Weber Barbara"'
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2. Cross-reactivity of pollen and food allergens: soybean Gly m 4 is a member of the Bet v 1 superfamily and closely resembles yellow lupine proteins
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Rösch Paul, Berkner Hanna, Neudecker Philipp, Mittag Diana, Ballmer-Weber Barbara, Lehn Peter, Schweimer Kristian, and Vieths Stefan
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Immunologic diseases. Allergy ,RC581-607 - Published
- 2011
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3. Threshold studies in food allergy
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Ballmer-Weber Barbara
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Immunologic diseases. Allergy ,RC581-607 - Published
- 2011
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4. Managing food allergy: GA2LEN guideline 2022
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Bansal, Priya, Berni–Canani, Roberto, Blumchen, Katharina, Bonertz, Andreas, Bourgoin-Heck, Melisande, Ceylon, Ozlem, Divaret-Chauveau, Amandine, Fleischer, David, Gomez, Maximiliano, Groetch, Marion, Hernandez, Domingo Barber, Hjorth, Betina, Hussey, Lydia Collins, Knulst, André C., Leung, Agnes, Mack, Douglas, Mahler, Vera, Mori, Francesca, Namazova-Baranova, Leyla, Palosuo, Kati, Parisi, Claudio Alberto Salvador, Pastorino, Antonio Carlos, Rudzeviciene, Odilija, Said, Maria, Sawiec, Piotr, Sicherer, Scott, Sato, Sakura, Zubchenko, Svitlana, Muraro, Antonella, de Silva, Debra, Halken, Susanne, Worm, Margitta, Khaleva, Ekaterina, Arasi, Stefania, Dunn-Galvin, Audrey, Nwaru, Bright I., De Jong, Nicolette W., Rodríguez Del Río, Pablo, Turner, Paul J., Smith, Pete, Begin, Philippe, Angier, Elizabeth, Arshad, Hasan, Ballmer-Weber, Barbara, Beyer, Kirsten, Bindslev-Jensen, Carsten, Cianferoni, Antonella, Demoulin, Céline, Deschildre, Antoine, Ebisawa, Motohiro, Fernandez-Rivas, Maria Montserrat, Fiocchi, Alessandro, Flokstra-de Blok, Bertine, Gerdts, Jennifer, Gradman, Josefine, Grimshaw, Kate, Jones, Carla, Lau, Susanne, Loh, Richard, Alvaro Lozano, Montserrat, Makela, Mika, Marchisotto, Mary Jane, Meyer, Rosan, Mills, Clare, Nilsson, Caroline, Nowak-Wegrzyn, Anna, Nurmatov, Ulugbek, Pajno, Giovanni, Podestà, Marcia, Poulsen, Lars K., Sampson, Hugh A., Sanchez, Angel, Schnadt, Sabine, Szajewska, Hania, Van Ree, Ronald, Venter, Carina, Vlieg-Boerstra, Berber, Warner, Amena, Wong, Gary, Wood, Robert, Zuberbier, Torsten, and Roberts, Graham
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- 2022
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5. Peanut Can Be Used as a Reference Allergen for Hazard Characterization in Food Allergen Risk Management: A Rapid Evidence Assessment and Meta-Analysis
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Turner, Paul J., Patel, Nandinee, Ballmer-Weber, Barbara K., Baumert, Joe L., Blom, W. Marty, Brooke-Taylor, Simon, Brough, Helen, Campbell, Dianne E., Chen, Hongbing, Chinthrajah, R. Sharon, Crevel, René W.R., Dubois, Anthony E.J., Ebisawa, Motohiro, Elizur, Arnon, Gerdts, Jennifer D., Gowland, M. Hazel, Houben, Geert F., Hourihane, Jonathan O.B., Knulst, André C., La Vieille, Sébastien, López, María Cristina, Mills, E.N. Clare, Polenta, Gustavo A., Purington, Natasha, Said, Maria, Sampson, Hugh A., Schnadt, Sabine, Södergren, Eva, Taylor, Stephen L., and Remington, Benjamin C.
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- 2022
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6. MY006: allergen-targeted antibodies for the treatment of peanut allergy
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Arena, Chiara, primary, Bieli, Dimitri, additional, Gasser, Pascal, additional, Götschi, Sandra, additional, Scheibling, Rahel, additional, Ilca, Tudor, additional, Paolucci, Marta, additional, Homère, Valentine, additional, Bouis, Delphine, additional, Martin-Rodriguez, Omayra, additional, Johansen, Pål, additional, Wang Yin, Kiave Ho, additional, Ballmer-Weber, Barbara, additional, Köhli, Alice, additional, Sonati, Tiziana, additional, Barberis, Alcide, additional, Pengo, Niccolo, additional, and Wuillemin, Natascha, additional
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- 2024
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7. Walnut Allergy Across Europe: Distribution of Allergen Sensitization Patterns and Prediction of Severity
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Lyons, Sarah A., Datema, Mareen R., Le, Thuy-My, Asero, Riccardo, Barreales, Laura, Belohlavkova, Simona, de Blay, Frédéric, Clausen, Michael, Dubakiene, Ruta, Fernández-Perez, Cristina, Fritsche, Philipp, Gislason, David, Hoffmann-Sommergruber, Karin, Jedrzejczak-Czechowicz, Monika, Jongejan, Laurian, Kowalski, Marek L., Kralimarkova, Tanya Z., Lidholm, Jonas, Papadopoulos, Nikolaos G., Pontoppidan, Bo, Popov, Todor A., Prado, Nayade del, Purohit, Ashok, Reig, Isabel, Seneviratne, Suranjith L., Sinaniotis, Athanasios, Vassilopoulou, Emilia, Versteeg, Serge A., Vieths, Stefan, Zwinderman, Aeilko H., Welsing, Paco M.J., Mills, E.N. Clare, Ballmer-Weber, Barbara K., Knulst, André C., Fernández-Rivas, Montserrat, and Van Ree, Ronald
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- 2021
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8. Predictors of Food Sensitization in Children and Adults Across Europe
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Lyons, Sarah A., Knulst, André C., Burney, Peter G.J., Fernández-Rivas, Montserrat, Ballmer-Weber, Barbara K., Barreales, Laura, Bieli, Christian, Clausen, Michael, Dubakiene, Ruta, Fernández-Perez, Cristina, Jedrzejczak-Czechowicz, Monika, Kowalski, Marek L., Kummeling, Ischa, Mustakov, Tihomir B., van Os-Medendorp, Harmieke, Papadopoulos, Nikolaos G., Popov, Todor A., Potts, James, Xepapadaki, Paraskevi, Welsing, Paco M.J., Mills, E. N. Clare, van Ree, Ronald, and Le, Thuy-My
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- 2020
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9. Prevalence of Food Sensitization and Food Allergy in Children Across Europe
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Lyons, Sarah A., Clausen, Michael, Knulst, André C., Ballmer-Weber, Barbara K., Fernandez-Rivas, Montserrat, Barreales, Laura, Bieli, Christian, Dubakiene, Ruta, Fernandez-Perez, Cristina, Jedrzejczak-Czechowicz, Monika, Kowalski, Marek L., Kralimarkova, Tanya, Kummeling, Ischa, Mustakov, Tihomir B., Papadopoulos, Nikolaos G., Popov, Todor A., Xepapadaki, Paraskevi, Welsing, Paco M.J., Potts, James, Mills, E.N. Clare, van Ree, Ronald, Burney, Peter G.J., and Le, Thuy-My
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- 2020
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10. Healthcare provision for insect venom allergy patients during the COVID-19 pandemic
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Worm, Margitta, Ballmer-Weber, Barbara, Brehler, Randolf, Cuevas, Mandy, Gschwend, Anna, Hartmann, Karin, Hawranek, Thomas, Hötzenecker, Wolfram, Homey, Bernhard, Jakob, Thilo, Novak, Natalija, Pickert, Julia, Saloga, Joachim, Schäkel, Knut, Trautmann, Axel, Treudler, Regina, Wedi, Bettina, Sturm, Gunter, and Rueff, Franziska
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- 2020
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11. Deriving individual threshold doses from clinical food challenge data for population risk assessment of food allergens
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Westerhout, Joost, Baumert, Joseph L., Blom, W. Marty, Allen, Katrina J., Ballmer-Weber, Barbara, Crevel, René W.R., Dubois, Anthony E.J., Fernández-Rivas, Montserrat, Greenhawt, Matthew J., Hourihane, Jonathan O'B., Koplin, Jennifer J., Kruizinga, Astrid G., Le, Thuy-My, Sampson, Hugh A., Shreffler, Wayne G., Turner, Paul J., Taylor, Steve L., Houben, Geert F., and Remington, Benjamin C.
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- 2019
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12. Is the concept of “peanut-free schools” useful in the routine management of peanut-allergic children at risk of anaphylaxis?: Position paper of the Food Allergy Working Group of the German Society for Allergology and Clinical Immunology (Deutsche Gesellschaft für Allergologie und klinische Immunologie, DGAKI)
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Reese, Imke, Ahrens, Birgit, Ballmer-Weber, Barbara, Beyer, Kirsten, Blümchen, Katharina, Doelle-Birke, Sabine, Heratizadeh, Annice, Kleine-Tebbe, Jörg, Lange, Lars, Lau, Susanne, Lepp, Ute, Mahler, Vera, Schäfer, Christiane, Schnadt, Sabine, Szepfalusi, Zsolt, Wassmann-Otto, Anja, Werfel, Thomas, and Worm, Margitta
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- 2020
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13. Dietary implications in acetylsalicylic acid intolerance: Statement by the Food Allergy Working Group of the German Society for Allergology and Clinical Immunology (DGAKI)
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Dölle-Bierke, Sabine, Plank-Habibi, Sibylle, Schäfer, Christiane, Ahrens, Birgit, Ballmer-Weber, Barbara, Beyer, Kirsten, Blümchen, Katharina, Huttegger, Isidor, Jappe, Uta, Kleine-Tebbe, Jörg, Lange, Lars, Lau, Susanne, Lepp, Ute, Mahler, Vera, Müller, Sabine, Saloga, Joachim, Schnadt, Sabine, Szepfalusi, Zsolt, Treudler, Regina, Wassmann-Otto, Anja, Werfel, Thomas, Zuberbier, Torsten, Reese, Imke, and Worm, Margitta
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- 2020
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14. Food Allergy in Adults: Substantial Variation in Prevalence and Causative Foods Across Europe
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Lyons, Sarah A., Burney, Peter G.J., Ballmer-Weber, Barbara K., Fernandez-Rivas, Montserrat, Barreales, Laura, Clausen, Michael, Dubakiene, Ruta, Fernandez-Perez, Cristina, Fritsche, Philipp, Jedrzejczak-Czechowicz, Monika, Kowalski, Marek L., Kralimarkova, Tanya, Kummeling, Ischa, Mustakov, Tihomir B., Lebens, Ans F.M., van Os-Medendorp, Harmieke, Papadopoulos, Nikolaos G., Popov, Todor A., Sakellariou, Alexandros, Welsing, Paco M.J., Potts, James, Mills, E.N. Clare, van Ree, Ronald, Knulst, André C., and Le, Thuy-My
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- 2019
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15. Allergen Recognition Patterns in Walnut Allergy Are Age Dependent and Correlate with the Severity of Allergic Reactions
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Ballmer-Weber, Barbara K., Lidholm, Jonas, Lange, Lars, Pascal, Mariona, Lang, Claudia, Gernert, Sunhild, Lozano-Blasco, Jaime, Gräni, Nora, Guillod, Caroline, Wangorsch, Andrea, Hanschmann, Kay-Martin, Pontoppidan, Bo, Tjäder, Linda, Bartra, Joan, and Vieths, Stefan
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- 2019
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16. Międzynarodowe wytyczne EAACI/GA2LEN/EuroGuiDerm/ APAAACI dotyczące definicji, klasyfikacji, diagnostyki i leczenia pokrzywki.
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Zuberbier, Torsten, Latiff, Amir Hamzah Abdul, Abuzakouk, Mohamed, Aquilina, Susan, Asero, Riccardo, Baker, Diane R., Ballmer-Weber, Barbara, Bangert, Christine, Ben-Shoshan, Moshe, Bernstein, Jonathan A., Bindslev-Jensen, Carsten, Brockow, Knut, Brzoza, Zenon, Neto, Herberto Jose Chong, Church, Martin K., Criado, Paulo R., Danilycheva, Inna V., Dressler, Corinna, Ensina, Luis Felipe, and Fonacier, Luz
- Abstract
Copyright of Polish Journal of Allergology / Alergologia Polska is the property of Termedia Publishing House and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2024
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17. EAACI guidelines on the diagnosis of IgE‐mediated food allergy
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Santos, Alexandra F., primary, Riggioni, Carmen, additional, Agache, Ioana, additional, Akdis, Cezmi A., additional, Akdis, Mubeccel, additional, Alvarez‐Perea, Alberto, additional, Alvaro‐Lozano, Montserrat, additional, Ballmer‐Weber, Barbara, additional, Barni, Simona, additional, Beyer, Kirsten, additional, Bindslev‐Jensen, Carsten, additional, Brough, Helen A., additional, Buyuktiryaki, Betul, additional, Chu, Derek, additional, Del Giacco, Stefano, additional, Dunn‐Galvin, Audrey, additional, Eberlein, Bernadette, additional, Ebisawa, Motohiro, additional, Eigenmann, Philippe, additional, Eiwegger, Thomas, additional, Feeney, Mary, additional, Fernandez‐Rivas, Montserrat, additional, Fisher, Helen R., additional, Fleischer, David M., additional, Giovannini, Mattia, additional, Gray, Claudia, additional, Hoffmann‐Sommergruber, Karin, additional, Halken, Susanne, additional, Hourihane, Jonathan O’B., additional, Jones, Christina J., additional, Jutel, Marek, additional, Knol, Edward, additional, Konstantinou, George N., additional, Lack, Gideon, additional, Lau, Susanne, additional, Marques Mejias, Andreina, additional, Marchisotto, Mary Jane, additional, Meyer, Rosan, additional, Mortz, Charlotte G., additional, Moya, Beatriz, additional, Muraro, Antonella, additional, Nilsson, Caroline, additional, Lopes de Oliveira, Lucila Camargo, additional, O’Mahony, Liam, additional, Papadopoulos, Nikolaos G., additional, Perrett, Kirsten, additional, Peters, Rachel L., additional, Podesta, Marcia, additional, Poulsen, Lars K., additional, Roberts, Graham, additional, Sampson, Hugh A., additional, Schwarze, Jürgen, additional, Smith, Peter, additional, Tham, Elizabeth Huiwen, additional, Untersmayr, Eva, additional, Van Ree, Ronald, additional, Venter, Carina, additional, Vickery, Brian P., additional, Vlieg‐Boerstra, Berber, additional, Werfel, Thomas, additional, Worm, Margitta, additional, Du Toit, George, additional, and Skypala, Isabel, additional
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- 2023
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18. Combining 2-DE immunoblots and mass spectrometry to identify putative soybean (Glycine max) allergens
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Lu, Mei, Jin, Yuan, Cerny, Ron, Ballmer-Weber, Barbara, and Goodman, Richard E.
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- 2018
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19. A comparative study of human IgE binding to proteins of a genetically modified (GM) soybean and six non-GM soybeans grown in multiple locations
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Lu, Mei, Jin, Yuan, Ballmer-Weber, Barbara, and Goodman, Richard E.
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- 2018
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20. Molekulare Diagnostik der Gemüse- und Fruchtallergie
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Ballmer-Weber, Barbara, Hoffmann-Sommergruber, Karin, Kleine-Tebbe, Jörg, editor, and Jakob, Thilo, editor
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- 2015
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21. Bet v 1 und Homologe: Verursacher der Baumpollenallergie und Birkenpollen-assoziierter Kreuzreaktionen
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Kleine-Tebbe, Jörg, Ballmer-Weber, Barbara, Breiteneder, Heimo, Vieths, Stefan, Kleine-Tebbe, Jörg, editor, and Jakob, Thilo, editor
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- 2015
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22. EAACI Molecular Allergology User's Guide 2.0
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Dramburg, Stephanie, primary, Hilger, Christiane, additional, Santos, Alexandra F., additional, de las Vecillas, Leticia, additional, Aalberse, Rob C., additional, Acevedo, Nathalie, additional, Aglas, Lorenz, additional, Altmann, Friedrich, additional, Arruda, Karla L., additional, Asero, Riccardo, additional, Ballmer‐Weber, Barbara, additional, Barber, Domingo, additional, Beyer, Kirsten, additional, Biedermann, Tilo, additional, Bilo, Maria Beatrice, additional, Blank, Simon, additional, Bosshard, Philipp P., additional, Breiteneder, Heimo, additional, Brough, Helen A., additional, Bublin, Merima, additional, Campbell, Dianne, additional, Caraballo, Luis, additional, Caubet, Jean Christoph, additional, Celi, Giorgio, additional, Chapman, Martin D., additional, Chruszcz, Maksymilian, additional, Custovic, Adnan, additional, Czolk, Rebecca, additional, Davies, Janet, additional, Douladiris, Nikolaos, additional, Eberlein, Bernadette, additional, Ebisawa, Motohiro, additional, Ehlers, Anna, additional, Eigenmann, Philippe, additional, Gadermaier, Gabriele, additional, Giovannini, Mattia, additional, Gomez, Francisca, additional, Grohman, Rebecca, additional, Guillet, Carole, additional, Hafner, Christine, additional, Hamilton, Robert G., additional, Hauser, Michael, additional, Hawranek, Thomas, additional, Hoffmann, Hans Jürgen, additional, Holzhauser, Thomas, additional, Iizuka, Tomona, additional, Jacquet, Alain, additional, Jakob, Thilo, additional, Janssen‐Weets, Bente, additional, Jappe, Uta, additional, Jutel, Marek, additional, Kalic, Tanja, additional, Kamath, Sandip, additional, Kespohl, Sabine, additional, Kleine‐Tebbe, Jörg, additional, Knol, Edward, additional, Knulst, André, additional, Konradsen, Jon R., additional, Korošec, Peter, additional, Kuehn, Annette, additional, Lack, Gideon, additional, Le, Thuy‐My, additional, Lopata, Andreas, additional, Luengo, Olga, additional, Mäkelä, Mika, additional, Marra, Alessandro Maria, additional, Mills, Clare, additional, Morisset, Martine, additional, Muraro, Antonella, additional, Nowak‐Wegrzyn, Anna, additional, Nugraha, Roni, additional, Ollert, Markus, additional, Palosuo, Kati, additional, Pastorello, Elide Anna, additional, Patil, Sarita Ulhas, additional, Platts‐Mills, Thomas, additional, Pomés, Anna, additional, Poncet, Pascal, additional, Potapova, Ekaterina, additional, Poulsen, Lars K., additional, Radauer, Christian, additional, Radulovic, Suzana, additional, Raulf, Monika, additional, Rougé, Pierre, additional, Sastre, Joaquin, additional, Sato, Sakura, additional, Scala, Enrico, additional, Schmid, Johannes M., additional, Schmid‐Grendelmeier, Peter, additional, Schrama, Denise, additional, Sénéchal, Hélène, additional, Traidl‐Hoffmann, Claudia, additional, Valverde‐Monge, Marcela, additional, van Hage, Marianne, additional, van Ree, Ronald, additional, Verhoeckx, Kitty, additional, Vieths, Stefan, additional, Wickman, Magnus, additional, Zakzuk, Josefina, additional, Matricardi, Paolo M., additional, and Hoffmann‐Sommergruber, Karin, additional
- Published
- 2023
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23. Targeting Ara h 2 with human‐derived monoclonal antibodies prevents peanut‐induced anaphylaxis in mice
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Paolucci, Marta, primary, Wuillemin, Natascha, additional, Homère, Valentine, additional, Bieli, Dimitri, additional, Köhli, Alice, additional, Ballmer‐Weber, Barbara, additional, Waeckerle‐Men, Ying, additional, Pengo, Niccolò, additional, Kündig, Thomas M., additional, Sonati, Tiziana, additional, and Johansen, Pål, additional
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- 2023
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24. EAACI Molecular Allergology User's Guide 2.0
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Dramburg, Stephanie, Hilger, Christiane, Santos, Alexandra F., de las Vecillas, Leticia, Aalberse, Rob C., Acevedo, Nathalie, Aglas, Lorenz, Altmann, Friedrich, Arruda, Karla L., Asero, Riccardo, Ballmer-Weber, Barbara, Barber, Domingo, Beyer, Kirsten, Biedermann, Tilo, Bilo, Maria Beatrice, Blank, Simon, Bosshard, Philipp P, Breiteneder, Heimo, Brough, Helen A., Bublin, Merima, Campbell, Dianne, Caraballo, Luis, Caubet, Jean Christoph, Celi, Giorgio, Chapman, Martin D., Chruszcz, Maksymilian, Custovic, Adnan, Czolk, Rebecca, Davies, Janet, Douladiris, Nikolaos, Eberlein, Bernadette, Ebisawa, Motohiro, Ehlers, Anna, Eigenmann, Philippe, Gadermaier, Gabriele, Giovannini, Mattia, Gomez, Francisca, Grohman, Rebecca, Guillet, Carole, Hafner, Christine, Hamilton, Robert G, Hauser, Michael, Hawranek, Thomas, Hoffmann, Hans Jürgen, Holzhauser, Thomas, Iizuka, Tomona, Jacquet, Alain, Jakob, Thilo, Janssen-Weets, Bente, Jappe, Uta, Jutel, Marek, Kalic, Tanja, Kamath, Sandip, Kespohl, Sabine, Kleine-Tebbe, Jörg, Knol, Edward, Knulst, André, Konradsen, Jon R., Korošec, Peter, Kuehn, Annette, Lack, Gideon, Le, Thuy My, Lopata, Andreas, Luengo, Olga, Mäkelä, Mika, Marra, Alessandro Maria, Mills, Clare, Morisset, Martine, Muraro, Antonella, Nowak-Wegrzyn, Anna, Nugraha, Roni, Ollert, Markus, Palosuo, Kati, Pastorello, Elide Anna, Patil, Sarita Ulhas, Platts-Mills, Thomas, Pomés, Anna, Poncet, Pascal, Potapova, Ekaterina, Poulsen, Lars K., Radauer, Christian, Radulovic, Suzana, Raulf, Monika, Rougé, Pierre, Sastre, Joaquin, Sato, Sakura, Scala, Enrico, Schmid, Johannes M., Schmid-Grendelmeier, Peter, Schrama, Denise, Sénéchal, Hélène, Traidl-Hoffmann, Claudia, Valverde-Monge, Marcela, van Hage, Marianne, van Ree, Ronald, Verhoeckx, Kitty, Vieths, Stefan, Wickman, Magnus, Zakzuk, Josefina, Matricardi, Paolo M, Hoffmann-Sommergruber, Karin, Dramburg, Stephanie, Hilger, Christiane, Santos, Alexandra F., de las Vecillas, Leticia, Aalberse, Rob C., Acevedo, Nathalie, Aglas, Lorenz, Altmann, Friedrich, Arruda, Karla L., Asero, Riccardo, Ballmer-Weber, Barbara, Barber, Domingo, Beyer, Kirsten, Biedermann, Tilo, Bilo, Maria Beatrice, Blank, Simon, Bosshard, Philipp P, Breiteneder, Heimo, Brough, Helen A., Bublin, Merima, Campbell, Dianne, Caraballo, Luis, Caubet, Jean Christoph, Celi, Giorgio, Chapman, Martin D., Chruszcz, Maksymilian, Custovic, Adnan, Czolk, Rebecca, Davies, Janet, Douladiris, Nikolaos, Eberlein, Bernadette, Ebisawa, Motohiro, Ehlers, Anna, Eigenmann, Philippe, Gadermaier, Gabriele, Giovannini, Mattia, Gomez, Francisca, Grohman, Rebecca, Guillet, Carole, Hafner, Christine, Hamilton, Robert G, Hauser, Michael, Hawranek, Thomas, Hoffmann, Hans Jürgen, Holzhauser, Thomas, Iizuka, Tomona, Jacquet, Alain, Jakob, Thilo, Janssen-Weets, Bente, Jappe, Uta, Jutel, Marek, Kalic, Tanja, Kamath, Sandip, Kespohl, Sabine, Kleine-Tebbe, Jörg, Knol, Edward, Knulst, André, Konradsen, Jon R., Korošec, Peter, Kuehn, Annette, Lack, Gideon, Le, Thuy My, Lopata, Andreas, Luengo, Olga, Mäkelä, Mika, Marra, Alessandro Maria, Mills, Clare, Morisset, Martine, Muraro, Antonella, Nowak-Wegrzyn, Anna, Nugraha, Roni, Ollert, Markus, Palosuo, Kati, Pastorello, Elide Anna, Patil, Sarita Ulhas, Platts-Mills, Thomas, Pomés, Anna, Poncet, Pascal, Potapova, Ekaterina, Poulsen, Lars K., Radauer, Christian, Radulovic, Suzana, Raulf, Monika, Rougé, Pierre, Sastre, Joaquin, Sato, Sakura, Scala, Enrico, Schmid, Johannes M., Schmid-Grendelmeier, Peter, Schrama, Denise, Sénéchal, Hélène, Traidl-Hoffmann, Claudia, Valverde-Monge, Marcela, van Hage, Marianne, van Ree, Ronald, Verhoeckx, Kitty, Vieths, Stefan, Wickman, Magnus, Zakzuk, Josefina, Matricardi, Paolo M, and Hoffmann-Sommergruber, Karin
- Abstract
Since the discovery of immunoglobulin E (IgE) as a mediator of allergic diseases in 1967, our knowledge about the immunological mechanisms of IgE-mediated allergies has remarkably increased. In addition to understanding the immune response and clinical symptoms, allergy diagnosis and management depend strongly on the precise identification of the elicitors of the IgE-mediated allergic reaction. In the past four decades, innovations in bioscience and technology have facilitated the identification and production of well-defined, highly pure molecules for component-resolved diagnosis (CRD), allowing a personalized diagnosis and management of the allergic disease for individual patients. The first edition of the “EAACI Molecular Allergology User's Guide” (MAUG) in 2016 rapidly became a key reference for clinicians, scientists, and interested readers with a background in allergology, immunology, biology, and medicine. Nevertheless, the field of molecular allergology is moving fast, and after 6 years, a new EAACI Taskforce was established to provide an updated document. The Molecular Allergology User's Guide 2.0 summarizes state-of-the-art information on allergen molecules, their clinical relevance, and their application in diagnostic algorithms for clinical practice. It is designed for both, clinicians and scientists, guiding health care professionals through the overwhelming list of different allergen molecules available for testing. Further, it provides diagnostic algorithms on the clinical relevance of allergenic molecules and gives an overview of their biology, the basic mechanisms of test formats, and the application of tests to measure allergen exposure.
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- 2023
25. EAACI guidelines on the diagnosis of IgE-mediated food allergy
- Author
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CTI Research, MS Dermatologie/Allergologie, Infection & Immunity, Santos, Alexandra F, Riggioni, Carmen, Agache, Ioana, Akdis, Cezmi A, Akdis, Mubeccel, Alvarez-Perea, Alberto, Alvaro-Lozano, Montserrat, Ballmer-Weber, Barbara, Barni, Simona, Beyer, Kirsten, Bindslev-Jensen, Carsten, Brough, Helen A, Buyuktiryaki, Betul, Chu, Derek, Del Giacco, Stefano, Dunn-Galvin, Audrey, Eberlein, Bernadette, Ebisawa, Motohiro, Eigenmann, Philippe, Eiwegger, Thomas, Feeney, Mary, Fernandez-Rivas, Montserrat, Fisher, Helen R, Fleischer, David M, Giovannini, Mattia, Gray, Claudia, Hoffmann-Sommergruber, Karin, Halken, Susanne, Hourihane, Jonathan O'B, Jones, Christina J, Jutel, Marek, Knol, Edward, Konstantinou, George N, Lack, Gideon, Lau, Susanne, Marques Mejias, Andreina, Marchisotto, Mary Jane, Meyer, Rosan, Mortz, Charlotte G, Moya, Beatriz, Muraro, Antonella, Nilsson, Caroline, Lopes de Oliveira, Lucila Camargo, O'Mahony, Liam, Papadopoulos, Nikolaos G, Perrett, Kirsten, Peters, Rachel L, Podesta, Marcia, Poulsen, Lars K, Roberts, Graham, Sampson, Hugh A, Schwarze, Jürgen, Smith, Peter, Tham, Elizabeth Huiwen, Untersmayr, Eva, Van Ree, Ronald, Venter, Carina, Vickery, Brian P, Vlieg-Boerstra, Berber, Werfel, Thomas, Worm, Margitta, Du Toit, George, Skypala, Isabel, CTI Research, MS Dermatologie/Allergologie, Infection & Immunity, Santos, Alexandra F, Riggioni, Carmen, Agache, Ioana, Akdis, Cezmi A, Akdis, Mubeccel, Alvarez-Perea, Alberto, Alvaro-Lozano, Montserrat, Ballmer-Weber, Barbara, Barni, Simona, Beyer, Kirsten, Bindslev-Jensen, Carsten, Brough, Helen A, Buyuktiryaki, Betul, Chu, Derek, Del Giacco, Stefano, Dunn-Galvin, Audrey, Eberlein, Bernadette, Ebisawa, Motohiro, Eigenmann, Philippe, Eiwegger, Thomas, Feeney, Mary, Fernandez-Rivas, Montserrat, Fisher, Helen R, Fleischer, David M, Giovannini, Mattia, Gray, Claudia, Hoffmann-Sommergruber, Karin, Halken, Susanne, Hourihane, Jonathan O'B, Jones, Christina J, Jutel, Marek, Knol, Edward, Konstantinou, George N, Lack, Gideon, Lau, Susanne, Marques Mejias, Andreina, Marchisotto, Mary Jane, Meyer, Rosan, Mortz, Charlotte G, Moya, Beatriz, Muraro, Antonella, Nilsson, Caroline, Lopes de Oliveira, Lucila Camargo, O'Mahony, Liam, Papadopoulos, Nikolaos G, Perrett, Kirsten, Peters, Rachel L, Podesta, Marcia, Poulsen, Lars K, Roberts, Graham, Sampson, Hugh A, Schwarze, Jürgen, Smith, Peter, Tham, Elizabeth Huiwen, Untersmayr, Eva, Van Ree, Ronald, Venter, Carina, Vickery, Brian P, Vlieg-Boerstra, Berber, Werfel, Thomas, Worm, Margitta, Du Toit, George, and Skypala, Isabel
- Published
- 2023
26. EAACI Molecular Allergology User's Guide 2.0
- Author
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CTI Research, MS Dermatologie/Allergologie, Infection & Immunity, Dramburg, Stephanie, Hilger, Christiane, Santos, Alexandra F, de Las Vecillas, Leticia, Aalberse, Rob C, Acevedo, Nathalie, Aglas, Lorenz, Altmann, Friedrich, Arruda, Karla L, Asero, Riccardo, Ballmer-Weber, Barbara, Barber, Domingo, Beyer, Kirsten, Biedermann, Tilo, Bilo, Maria Beatrice, Blank, Simon, Bosshard, Philipp P, Breiteneder, Heimo, Brough, Helen A, Bublin, Merima, Campbell, Dianne, Caraballo, Luis, Caubet, Jean Christoph, Celi, Giorgio, Chapman, Martin D, Chruszcz, Maksymilian, Custovic, Adnan, Czolk, Rebecca, Davies, Janet, Douladiris, Nikolaos, Eberlein, Bernadette, Ebisawa, Motohiro, Ehlers, Anna, Eigenmann, Philippe, Gadermaier, Gabriele, Giovannini, Mattia, Gomez, Francisca, Grohman, Rebecca, Guillet, Carole, Hafner, Christine, Hamilton, Robert G, Hauser, Michael, Hawranek, Thomas, Hoffmann, Hans Jürgen, Holzhauser, Thomas, Iizuka, Tomona, Jacquet, Alain, Jakob, Thilo, Janssen-Weets, Bente, Jappe, Uta, Jutel, Marek, Kalic, Tanja, Kamath, Sandip, Kespohl, Sabine, Kleine-Tebbe, Jörg, Knol, Edward, Knulst, André, Konradsen, Jon R, Korošec, Peter, Kuehn, Annette, Lack, Gideon, Le, Thuy-My, Lopata, Andreas, Luengo, Olga, Mäkelä, Mika, Marra, Alessandro Maria, Mills, Clare, Morisset, Martine, Muraro, Antonella, Nowak-Wegrzyn, Anna, Nugraha, Roni, Ollert, Markus, Palosuo, Kati, Pastorello, Elide Anna, Patil, Sarita Ulhas, Platts-Mills, Thomas, Pomés, Anna, Poncet, Pascal, Potapova, Ekaterina, Poulsen, Lars K, Radauer, Christian, Radulovic, Suzana, Raulf, Monika, Rougé, Pierre, Sastre, Joaquin, Sato, Sakura, Scala, Enrico, Schmid, Johannes M, Schmid-Grendelmeier, Peter, Schrama, Denise, Sénéchal, Hélène, Traidl-Hoffmann, Claudia, Valverde-Monge, Marcela, van Hage, Marianne, van Ree, Ronald, Verhoeckx, Kitty, Vieths, Stefan, Wickman, Magnus, Zakzuk, Josefina, Matricardi, Paolo M, Hoffmann-Sommergruber, Karin, CTI Research, MS Dermatologie/Allergologie, Infection & Immunity, Dramburg, Stephanie, Hilger, Christiane, Santos, Alexandra F, de Las Vecillas, Leticia, Aalberse, Rob C, Acevedo, Nathalie, Aglas, Lorenz, Altmann, Friedrich, Arruda, Karla L, Asero, Riccardo, Ballmer-Weber, Barbara, Barber, Domingo, Beyer, Kirsten, Biedermann, Tilo, Bilo, Maria Beatrice, Blank, Simon, Bosshard, Philipp P, Breiteneder, Heimo, Brough, Helen A, Bublin, Merima, Campbell, Dianne, Caraballo, Luis, Caubet, Jean Christoph, Celi, Giorgio, Chapman, Martin D, Chruszcz, Maksymilian, Custovic, Adnan, Czolk, Rebecca, Davies, Janet, Douladiris, Nikolaos, Eberlein, Bernadette, Ebisawa, Motohiro, Ehlers, Anna, Eigenmann, Philippe, Gadermaier, Gabriele, Giovannini, Mattia, Gomez, Francisca, Grohman, Rebecca, Guillet, Carole, Hafner, Christine, Hamilton, Robert G, Hauser, Michael, Hawranek, Thomas, Hoffmann, Hans Jürgen, Holzhauser, Thomas, Iizuka, Tomona, Jacquet, Alain, Jakob, Thilo, Janssen-Weets, Bente, Jappe, Uta, Jutel, Marek, Kalic, Tanja, Kamath, Sandip, Kespohl, Sabine, Kleine-Tebbe, Jörg, Knol, Edward, Knulst, André, Konradsen, Jon R, Korošec, Peter, Kuehn, Annette, Lack, Gideon, Le, Thuy-My, Lopata, Andreas, Luengo, Olga, Mäkelä, Mika, Marra, Alessandro Maria, Mills, Clare, Morisset, Martine, Muraro, Antonella, Nowak-Wegrzyn, Anna, Nugraha, Roni, Ollert, Markus, Palosuo, Kati, Pastorello, Elide Anna, Patil, Sarita Ulhas, Platts-Mills, Thomas, Pomés, Anna, Poncet, Pascal, Potapova, Ekaterina, Poulsen, Lars K, Radauer, Christian, Radulovic, Suzana, Raulf, Monika, Rougé, Pierre, Sastre, Joaquin, Sato, Sakura, Scala, Enrico, Schmid, Johannes M, Schmid-Grendelmeier, Peter, Schrama, Denise, Sénéchal, Hélène, Traidl-Hoffmann, Claudia, Valverde-Monge, Marcela, van Hage, Marianne, van Ree, Ronald, Verhoeckx, Kitty, Vieths, Stefan, Wickman, Magnus, Zakzuk, Josefina, Matricardi, Paolo M, and Hoffmann-Sommergruber, Karin
- Published
- 2023
27. EAACI guidelines on the diagnosis of IgE‐mediated food allergy
- Author
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Santos, Alexandra F; https://orcid.org/0000-0002-7805-1436, Riggioni, Carmen; https://orcid.org/0000-0002-8745-0228, Agache, Ioana; https://orcid.org/0000-0001-7994-364X, Akdis, Cezmi A; https://orcid.org/0000-0001-8020-019X, Akdis, Mubeccel; https://orcid.org/0000-0003-0554-9943, Alvarez‐Perea, Alberto; https://orcid.org/0000-0001-7417-7309, Alvaro‐Lozano, Montserrat; https://orcid.org/0000-0002-5528-8043, Ballmer‐Weber, Barbara; https://orcid.org/0000-0002-4136-5036, Barni, Simona, Beyer, Kirsten, Bindslev‐Jensen, Carsten; https://orcid.org/0000-0002-8940-038X, Brough, Helen A; https://orcid.org/0000-0001-7203-0813, Buyuktiryaki, Betul, Chu, Derek, Del Giacco, Stefano; https://orcid.org/0000-0002-4517-1749, Dunn‐Galvin, Audrey; https://orcid.org/0000-0002-1540-3959, Eberlein, Bernadette; https://orcid.org/0000-0003-4509-6491, Ebisawa, Motohiro; https://orcid.org/0000-0003-4117-558X, Eigenmann, Philippe, Eiwegger, Thomas; https://orcid.org/0000-0002-2914-7829, Feeney, Mary; https://orcid.org/0000-0003-0594-7052, Fernandez‐Rivas, Montserrat; https://orcid.org/0000-0003-1748-2328, Fisher, Helen R; https://orcid.org/0000-0002-5958-4587, Fleischer, David M, Giovannini, Mattia; https://orcid.org/0000-0001-9568-6882, Gray, Claudia, Hoffmann‐Sommergruber, Karin; https://orcid.org/0000-0002-8830-058X, Halken, Susanne; https://orcid.org/0000-0003-0161-8278, Hourihane, Jonathan O’B, Jones, Christina J; https://orcid.org/0000-0003-3672-6631, et al, Santos, Alexandra F; https://orcid.org/0000-0002-7805-1436, Riggioni, Carmen; https://orcid.org/0000-0002-8745-0228, Agache, Ioana; https://orcid.org/0000-0001-7994-364X, Akdis, Cezmi A; https://orcid.org/0000-0001-8020-019X, Akdis, Mubeccel; https://orcid.org/0000-0003-0554-9943, Alvarez‐Perea, Alberto; https://orcid.org/0000-0001-7417-7309, Alvaro‐Lozano, Montserrat; https://orcid.org/0000-0002-5528-8043, Ballmer‐Weber, Barbara; https://orcid.org/0000-0002-4136-5036, Barni, Simona, Beyer, Kirsten, Bindslev‐Jensen, Carsten; https://orcid.org/0000-0002-8940-038X, Brough, Helen A; https://orcid.org/0000-0001-7203-0813, Buyuktiryaki, Betul, Chu, Derek, Del Giacco, Stefano; https://orcid.org/0000-0002-4517-1749, Dunn‐Galvin, Audrey; https://orcid.org/0000-0002-1540-3959, Eberlein, Bernadette; https://orcid.org/0000-0003-4509-6491, Ebisawa, Motohiro; https://orcid.org/0000-0003-4117-558X, Eigenmann, Philippe, Eiwegger, Thomas; https://orcid.org/0000-0002-2914-7829, Feeney, Mary; https://orcid.org/0000-0003-0594-7052, Fernandez‐Rivas, Montserrat; https://orcid.org/0000-0003-1748-2328, Fisher, Helen R; https://orcid.org/0000-0002-5958-4587, Fleischer, David M, Giovannini, Mattia; https://orcid.org/0000-0001-9568-6882, Gray, Claudia, Hoffmann‐Sommergruber, Karin; https://orcid.org/0000-0002-8830-058X, Halken, Susanne; https://orcid.org/0000-0003-0161-8278, Hourihane, Jonathan O’B, Jones, Christina J; https://orcid.org/0000-0003-3672-6631, and et al
- Abstract
This European Academy of Allergy and Clinical Immunology guideline provides recommendations for diagnosing IgE‐mediated food allergy and was developed using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach. Food allergy diagnosis starts with an allergy‐focused clinical history followed by tests to determine IgE sensitization, such as serum allergen‐specific IgE (sIgE) and skin prick test (SPT), and the basophil activation test (BAT), if available. Evidence for IgE sensitization should be sought for any suspected foods. The diagnosis of allergy to some foods, such as peanut and cashew nut, is well supported by SPT and serum sIgE, whereas there are less data and the performance of these tests is poorer for other foods, such as wheat and soya. The measurement of sIgE to allergen components such as Ara h 2 from peanut, Cor a 14 from hazelnut and Ana o 3 from cashew can be useful to further support the diagnosis, especially in pollen‐sensitized individuals. BAT to peanut and sesame can be used additionally. The reference standard for food allergy diagnosis is the oral food challenge (OFC). OFC should be performed in equivocal cases. For practical reasons, open challenges are suitable in most cases. Reassessment of food allergic children with allergy tests and/or OFCs periodically over time will enable reintroduction of food into the diet in the case of spontaneous acquisition of oral tolerance.
- Published
- 2023
28. EAACI Molecular Allergology User's Guide 2.0
- Author
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Dramburg, Stephanie; https://orcid.org/0000-0002-9303-3260, Hilger, Christiane; https://orcid.org/0000-0001-9455-5442, Santos, Alexandra F; https://orcid.org/0000-0002-7805-1436, de las Vecillas, Leticia; https://orcid.org/0000-0003-4969-5678, Aalberse, Rob C; https://orcid.org/0000-0002-3902-6596, Acevedo, Nathalie; https://orcid.org/0000-0002-5154-2964, Aglas, Lorenz; https://orcid.org/0000-0002-1236-5934, Altmann, Friedrich; https://orcid.org/0000-0002-0112-7877, Arruda, Karla L; https://orcid.org/0000-0002-7505-210X, Asero, Riccardo; https://orcid.org/0000-0002-8277-1700, Ballmer‐Weber, Barbara; https://orcid.org/0000-0002-4136-5036, Barber, Domingo; https://orcid.org/0000-0002-5488-5700, Beyer, Kirsten; https://orcid.org/0000-0003-1859-0419, Biedermann, Tilo; https://orcid.org/0000-0002-5352-5105, Bilo, Maria Beatrice; https://orcid.org/0000-0002-9324-6039, Blank, Simon; https://orcid.org/0000-0002-5649-1078, Bosshard, Philipp P; https://orcid.org/0000-0002-1154-2281, Breiteneder, Heimo; https://orcid.org/0000-0003-2022-8689, Brough, Helen A; https://orcid.org/0000-0001-7203-0813, Bublin, Merima; https://orcid.org/0000-0002-7191-9431, Campbell, Dianne; https://orcid.org/0000-0002-0907-6963, Caraballo, Luis; https://orcid.org/0000-0002-5204-1109, Caubet, Jean Christoph; https://orcid.org/0000-0001-5006-5724, Celi, Giorgio, Chapman, Martin D; https://orcid.org/0000-0002-0845-3632, Chruszcz, Maksymilian; https://orcid.org/0000-0001-7521-5485, Custovic, Adnan; https://orcid.org/0000-0001-5218-7071, Czolk, Rebecca; https://orcid.org/0000-0003-4296-3051, Davies, Janet; https://orcid.org/0000-0002-6378-4119, Douladiris, Nikolaos; https://orcid.org/0000-0003-4037-4421, et al, Dramburg, Stephanie; https://orcid.org/0000-0002-9303-3260, Hilger, Christiane; https://orcid.org/0000-0001-9455-5442, Santos, Alexandra F; https://orcid.org/0000-0002-7805-1436, de las Vecillas, Leticia; https://orcid.org/0000-0003-4969-5678, Aalberse, Rob C; https://orcid.org/0000-0002-3902-6596, Acevedo, Nathalie; https://orcid.org/0000-0002-5154-2964, Aglas, Lorenz; https://orcid.org/0000-0002-1236-5934, Altmann, Friedrich; https://orcid.org/0000-0002-0112-7877, Arruda, Karla L; https://orcid.org/0000-0002-7505-210X, Asero, Riccardo; https://orcid.org/0000-0002-8277-1700, Ballmer‐Weber, Barbara; https://orcid.org/0000-0002-4136-5036, Barber, Domingo; https://orcid.org/0000-0002-5488-5700, Beyer, Kirsten; https://orcid.org/0000-0003-1859-0419, Biedermann, Tilo; https://orcid.org/0000-0002-5352-5105, Bilo, Maria Beatrice; https://orcid.org/0000-0002-9324-6039, Blank, Simon; https://orcid.org/0000-0002-5649-1078, Bosshard, Philipp P; https://orcid.org/0000-0002-1154-2281, Breiteneder, Heimo; https://orcid.org/0000-0003-2022-8689, Brough, Helen A; https://orcid.org/0000-0001-7203-0813, Bublin, Merima; https://orcid.org/0000-0002-7191-9431, Campbell, Dianne; https://orcid.org/0000-0002-0907-6963, Caraballo, Luis; https://orcid.org/0000-0002-5204-1109, Caubet, Jean Christoph; https://orcid.org/0000-0001-5006-5724, Celi, Giorgio, Chapman, Martin D; https://orcid.org/0000-0002-0845-3632, Chruszcz, Maksymilian; https://orcid.org/0000-0001-7521-5485, Custovic, Adnan; https://orcid.org/0000-0001-5218-7071, Czolk, Rebecca; https://orcid.org/0000-0003-4296-3051, Davies, Janet; https://orcid.org/0000-0002-6378-4119, Douladiris, Nikolaos; https://orcid.org/0000-0003-4037-4421, and et al
- Abstract
Since the discovery of immunoglobulin E (IgE) as a mediator of allergic diseases in 1967, our knowledge about the immunological mechanisms of IgE‐mediated allergies has remarkably increased. In addition to understanding the immune response and clinical symptoms, allergy diagnosis and management depend strongly on the precise identification of the elicitors of the IgE‐mediated allergic reaction. In the past four decades, innovations in bioscience and technology have facilitated the identification and production of well‐defined, highly pure molecules for component‐resolved diagnosis (CRD), allowing a personalized diagnosis and management of the allergic disease for individual patients. The first edition of the “EAACI Molecular Allergology User's Guide” (MAUG) in 2016 rapidly became a key reference for clinicians, scientists, and interested readers with a background in allergology, immunology, biology, and medicine. Nevertheless, the field of molecular allergology is moving fast, and after 6 years, a new EAACI Taskforce was established to provide an updated document. The Molecular Allergology User's Guide 2.0 summarizes state‐of‐the‐art information on allergen molecules, their clinical relevance, and their application in diagnostic algorithms for clinical practice. It is designed for both, clinicians and scientists, guiding health care professionals through the overwhelming list of different allergen molecules available for testing. Further, it provides diagnostic algorithms on the clinical relevance of allergenic molecules and gives an overview of their biology, the basic mechanisms of test formats, and the application of tests to measure allergen exposure.
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- 2023
29. EAACI guidelines on the diagnosis of IgE-mediated food allergy
- Author
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Santos, Alexandra F, Riggioni, Carmen, Agache, Ioana, Akdis, Cezmi A, Akdis, Mubeccel, Alvarez-Perea, Alberto, Alvaro-Lozano, Montserrat, Ballmer-Weber, Barbara, Barni, Simona, Beyer, Kirsten, Bindslev-Jensen, Carsten, Brough, Helen A, Buyuktiryaki, Betul, Chu, Derek, Del Giacco, Stefano, Dunn-Galvin, Audrey, Eberlein, Bernadette, Ebisawa, Motohiro, Eigenmann, Philippe, Eiwegger, Thomas, Feeney, Mary, Fernandez-Rivas, Montserrat, Fisher, Helen R, Fleischer, David M, Giovannini, Mattia, Gray, Claudia, Hoffmann-Sommergruber, Karin, Halken, Susanne, Hourihane, Jonathan O'B, Jones, Christina J, Jutel, Marek, Knol, Edward, Konstantinou, George N, Lack, Gideon, Lau, Susanne, Marques Mejias, Andreina, Marchisotto, Mary Jane, Meyer, Rosan, Mortz, Charlotte G, Moya, Beatriz, Muraro, Antonella, Nilsson, Caroline, Lopes de Oliveira, Lucila Camargo, O'Mahony, Liam, Papadopoulos, Nikolaos G, Perrett, Kirsten, Peters, Rachel L, Podesta, Marcia, Poulsen, Lars K, Roberts, Graham, Sampson, Hugh A, Schwarze, Jürgen, Smith, Peter, Tham, Elizabeth Huiwen, Untersmayr, Eva, Van Ree, Ronald, Venter, Carina, Vickery, Brian P, Vlieg-Boerstra, Berber, Werfel, Thomas, Worm, Margitta, Du Toit, George, Skypala, Isabel, Santos, Alexandra F, Riggioni, Carmen, Agache, Ioana, Akdis, Cezmi A, Akdis, Mubeccel, Alvarez-Perea, Alberto, Alvaro-Lozano, Montserrat, Ballmer-Weber, Barbara, Barni, Simona, Beyer, Kirsten, Bindslev-Jensen, Carsten, Brough, Helen A, Buyuktiryaki, Betul, Chu, Derek, Del Giacco, Stefano, Dunn-Galvin, Audrey, Eberlein, Bernadette, Ebisawa, Motohiro, Eigenmann, Philippe, Eiwegger, Thomas, Feeney, Mary, Fernandez-Rivas, Montserrat, Fisher, Helen R, Fleischer, David M, Giovannini, Mattia, Gray, Claudia, Hoffmann-Sommergruber, Karin, Halken, Susanne, Hourihane, Jonathan O'B, Jones, Christina J, Jutel, Marek, Knol, Edward, Konstantinou, George N, Lack, Gideon, Lau, Susanne, Marques Mejias, Andreina, Marchisotto, Mary Jane, Meyer, Rosan, Mortz, Charlotte G, Moya, Beatriz, Muraro, Antonella, Nilsson, Caroline, Lopes de Oliveira, Lucila Camargo, O'Mahony, Liam, Papadopoulos, Nikolaos G, Perrett, Kirsten, Peters, Rachel L, Podesta, Marcia, Poulsen, Lars K, Roberts, Graham, Sampson, Hugh A, Schwarze, Jürgen, Smith, Peter, Tham, Elizabeth Huiwen, Untersmayr, Eva, Van Ree, Ronald, Venter, Carina, Vickery, Brian P, Vlieg-Boerstra, Berber, Werfel, Thomas, Worm, Margitta, Du Toit, George, and Skypala, Isabel
- Abstract
This European Academy of Allergy and Clinical Immunology guideline provides recommendations for diagnosing IgE-mediated food allergy and was developed using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach. Food allergy diagnosis starts with an allergy-focused clinical history followed by tests to determine IgE sensitization, such as serum allergen-specific IgE (sIgE) and skin prick test (SPT), and the basophil activation test (BAT), if available. Evidence for IgE sensitization should be sought for any suspected foods. The diagnosis of allergy to some foods, such as peanut and cashew nut, is well supported by SPT and serum sIgE, whereas there are less data and the performance of these tests is poorer for other foods, such as wheat and soya. The measurement of sIgE to allergen components such as Ara h 2 from peanut, Cor a 14 from hazelnut and Ana o 3 from cashew can be useful to further support the diagnosis, especially in pollen-sensitized individuals. BAT to peanut and sesame can be used additionally. The reference standard for food allergy diagnosis is the oral food challenge (OFC). OFC should be performed in equivocal cases. For practical reasons, open challenges are suitable in most cases. Reassessment of food allergic children with allergy tests and/or OFCs periodically over time will enable reintroduction of food into the diet in the case of spontaneous acquisition of oral tolerance.
- Published
- 2023
30. European Surveillance System on Contact Allergies (ESSCA)
- Author
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Loman, Laura, Uter, Wolfgang, Armario-Hita, José C., Ayala, Fabio, Balato, Anna, Ballmer-Weber, Barbara K., Bauer, Andrea, Bircher, Andreas J., Buhl, Timo, Czarnecka-Operacz, Magdalena, Dickel, Heinrich, Fuchs, Thomas, Giménez Arnau, Ana, John, Swen M., Kränke, Birger, Kręcisz, Beata, Mahler, Vera, Rustemeyer, Thomas, Sadowska-Przytocka, Anna, Sánchez-Pérez, Javier, Scherer Hofmeier, Kathrin, Schliemann, Sibylle, Simon, Dagmar, Spiewak, Radoslaw, Spring, Philip, Valiukevičienė, Skaidra, Wagner, Nicola, Weisshaar, Elke, Pesonen, Maria, Schuttelaar, Marie L. A., Aberer, Werner, Beiteke, Ulrike, Frosch, Peter, Werfel, Thomas, Elsner, Peter, Becker, Detlef, Sliuziaviciene, Gondinga, Kiec-Swierczynska, Marta, Silvestre, Juan F., Ruiz, Inmaculada, Mercader, Pedro, Fernández-Redondo, Virginia, García-Gavín, Juan, Grabbe, J. rgen, Navarini, Alexander, Loman, Laura, Uter, Wolfgang, Armario-Hita, José C, Ayala, Fabio, Balato, Anna, Ballmer-Weber, Barbara K, Bauer, Andrea, Bircher, Andreas J, Buhl, Timo, Czarnecka-Operacz, Magdalena, Dickel, Heinrich, Fuchs, Thoma, Giménez Arnau, Ana, John, Swen M, Kränke, Birger, Kręcisz, Beata, Mahler, Vera, Rustemeyer, Thoma, Sadowska-Przytocka, Anna, Sánchez-Pérez, Javier, Scherer Hofmeier, Kathrin, Schliemann, Sibylle, Simon, Dagmar, Spiewak, Radoslaw, Spring, Philip, Valiukevičienė, Skaidra, Wagner, Nicola, Weisshaar, Elke, Pesonen, Maria, Schuttelaar, Marie L A, Medicina, Dermatology, and Public Health Research (PHR)
- Subjects
medicine.medical_specialty ,Allergy ,IMPACT ,Population ,610 Medicine & health ,Dermatology ,Disease ,occupational contact dermatiti ,sensitization ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,irritant contact dermatitis ,Epidemiology ,medicine ,Immunology and Allergy ,ATOPIC-DERMATITIS ,Clinical significance ,030212 general & internal medicine ,NETWORK ,education ,RRID ,Allergic contact dermatitis ,patch testing ,education.field_of_study ,patch test ,Kontaktallergie ,allergic contact dermatitis ,body site ,contact allergy ,business.industry ,SCR_001905 [RRID] ,BASE-LINE SERIES ,Original Articles ,medicine.disease ,RRID:SCR_001905 ,3. Good health ,occupational contact dermatitis ,irritant contact dermatiti ,DISEASES ,Irritant contact dermatitis ,Original Article ,epidemiology ,eczema ,SCR_001905 ,business ,Contact dermatitis ,SKIN - Abstract
Background Irritant contact dermatitis (ICD) is caused by the acute locally toxic effect of a strong irritant, or the cumulative exposure to various weaker physical and/or chemical irritants. Objectives To describe characteristics of patients with ICD in the population patch tested in the European Surveillance System on Contact Allergies (ESSCA; www.essca-dc.org) database. Methods Data collected by the ESSCA in consecutively patch tested patients from January 2009 to December 2018 were analyzed. Results Of the 68 072 patients, 8702 patients were diagnosed with ICD (without concomitant allergic contact dermatitis [ACD]). Hand and face were the most reported anatomical sites, and 45.7% of the ICD was occupational ICD (OICD). The highest proportions of OICD were found in metal turners, bakers, pastry-cooks and confectionery makers. Among patients diagnosed with ICD, 45% were found sensitized with no relevance for the current disease. Conclusions The hands were mainly involved in OICD also in the subgroup of contact dermatitis patients, in whom relevant contact sensitization had been ruled out, emphasizing the need for limiting irritant exposures. However, in difficult to treat contact dermatitis, unrecognized contact allergy, or unrecognized clinical relevance of identified allergies owing to incomplete or wrong product ingredient information must always be considered. This article is protected by copyright. All rights reserved.
- Published
- 2021
31. Risk and safety requirements for diagnostic and therapeutic procedures in allergology: World Allergy Organization Statement
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Kowalski, Marek L., Ansotegui, Ignacio, Aberer, Werner, Al-Ahmad, Mona, Akdis, Mubeccel, Ballmer-Weber, Barbara K., Beyer, Kirsten, Blanca, Miguel, Brown, Simon, Bunnag, Chaweewan, Hulett, Arnaldo Capriles, Castells, Mariana, Chng, Hiok Hee, De Blay, Frederic, Ebisawa, Motohiro, Fineman, Stanley, Golden, David B.K., Haahtela, Tari, Kaliner, Michael, Katelaris, Connie, Lee, Bee Wah, Makowska, Joanna, Muller, Ulrich, Mullol, Joaquim, Oppenheimer, John, Park, Hae-Sim, Parkerson, James, Passalacqua, Giovanni, Pawankar, Ruby, Renz, Harald, Rueff, Franziska, Sanchez-Borges, Mario, Sastre, Joaquin, Scadding, Glenis, Sicherer, Scott, Tantilipikorn, Pongsakorn, Tracy, James, van Kempen, Vera, Bohle, Barbara, Canonica, G Walter, Caraballo, Luis, Gomez, Maximiliano, Ito, Komei, Jensen-Jarolim, Erika, Larche, Mark, Melioli, Giovanni, Poulsen, Lars K., Valenta, Rudolf, and Zuberbier, Torsten
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- 2016
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32. Multivariate allergen-specific analysis and profiling of serum antibodies from patients with peanut allergy
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Paolucci, Marta, Wuillemin, Natascha, Köhli, Alice, Ballmer-Weber, Barbara, Severin, Yannik, Waeckerle‐Men, Ying, Arena, Chiara, Homère, Valentine, Bieli, Dimitri, Kündig, Thomas M, Sonati, Tiziana, Johansen, Pål, University of Zurich, and Johansen, Pål
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2403 Immunology ,Immunology ,2723 Immunology and Allergy ,10177 Dermatology Clinic ,Immunology and Allergy ,610 Medicine & health - Published
- 2023
33. Vegan diets from an allergy point of view – Position paper of the DGAKI working group on food allergy
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Reese, Imke, primary, Schäfer, Christiane, additional, Ballmer-Weber, Barbara, additional, Beyer, Kirsten, additional, Dölle-Bierke, Sabine, additional, Dullemen, Suzanne van, additional, Jappe, Uta, additional, Müller, Sabine, additional, Schnadt, Sabine, additional, Treudler, Regina, additional, and Worm, Margitta, additional
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- 2023
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34. Hazelnut allergy across Europe dissected molecularly: A EuroPrevall outpatient clinic survey
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Datema, Mareen R., Zuidmeer-Jongejan, Laurian, Asero, Riccardo, Barreales, Laura, Belohlavkova, Simona, de Blay, Frédéric, Bures, Peter, Clausen, Michael, Dubakiene, Ruta, Gislason, David, Jedrzejczak-Czechowicz, Monika, Kowalski, Marek L., Knulst, André C., Kralimarkova, Tanya, Le, Thuy-My, Lovegrove, Alison, Marsh, Justin, Papadopoulos, Nikolaos G., Popov, Todor, del Prado, Náyade, Purohit, Ashok, Reese, Gerald, Reig, Isabel, Seneviratne, Suranjith L., Sinaniotis, Athanasios, Versteeg, Serge A., Vieths, Stefan, Zwinderman, Aeilko H., Mills, Clare, Lidholm, Jonas, Hoffmann-Sommergruber, Karin, Fernández-Rivas, Montserrat, Ballmer-Weber, Barbara, and van Ree, Ronald
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- 2015
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35. How much is too much? Threshold dose distributions for 5 food allergens
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Ballmer-Weber, Barbara K., Fernandez-Rivas, Montserrat, Beyer, Kirsten, Defernez, Marianne, Sperrin, Matthew, Mackie, Alan R., Salt, Louise J., Hourihane, Jonathan O'B., Asero, Riccardo, Belohlavkova, Simona, Kowalski, Marek, de Blay, Frédéric, Papadopoulos, Nikolaos G., Clausen, Michael, Knulst, André C., Roberts, Graham, Popov, Ted, Sprikkelman, Aline B., Dubakiene, Ruta, Vieths, Stefan, van Ree, Ronald, Crevel, René, and Mills, E.N. Clare
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- 2015
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36. Multivariate allergen‐specific analysis and profiling of serum antibodies from patients with peanut allergy
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Paolucci, Marta, primary, Wuillemin, Natascha, additional, Köhli, Alice, additional, Ballmer‐Weber, Barbara, additional, Severin, Yannik, additional, Waeckerle‐Men, Ying, additional, Arena, Chiara, additional, Homère, Valentine, additional, Bieli, Dimitri, additional, Kündig, Thomas M., additional, Sonati, Tiziana, additional, and Johansen, Pål, additional
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- 2022
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37. German guideline for the management of adverse reactions to ingested histamine: Guideline of the German Society for Allergology and Clinical Immunology (DGAKI), the German Society for Pediatric Allergology and Environmental Medicine (GPA), the German Association of Allergologists (AeDA), and the Swiss Society for Allergology and Immunology (SGAI)
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Reese, Imke, Ballmer-Weber, Barbara, Beyer, Kirsten, Fuchs, Thomas, Kleine-Tebbe, Jörg, Klimek, Ludger, Lepp, Ute, Niggemann, Bodo, Saloga, Joachim, Schäfer, Christiane, Werfel, Thomas, Zuberbier, Torsten, and Worm, Margitta
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- 2017
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38. Treatment of chronic spontaneous urticaria with an inadequate response to H1-antihistamines: an expert opinion
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Vestergaard, Christian, Toubi, Elias, Maurer, Marcus, Triggiani, Massimo, Ballmer-Weber, Barbara, Marsland, Alexander, Ferrer, Marta, Knulst, André, and Giménez-Arnau, Ana
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- 2017
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39. Multivariate allergen-specific profiling of serum antibodies from patients with peanut allergy
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Paolucci Marta, Wuillemin Natascha, Köhli Alice, Ballmer-Weber Barbara, Severin Yannik, Waeckerle-Men Ying, Arena Chiara, Homère Valentine, Bieli Dimitri, Kündig Thomas M., Sonati Tiziana, and Johansen Pål
- Abstract
Information about the study methods of the research letter submitted to 'Clinical and Experimental Allergy'
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- 2022
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40. Managing food allergy: GA2LEN guideline 2022
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Muraro, Antonella, de Silva, Debra, Halken, Susanne, Worm, Margitta, et al, Ballmer-Weber, Barbara, University of Zurich, and Muraro, Antonella
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Pulmonary and Respiratory Medicine ,2403 Immunology ,2740 Pulmonary and Respiratory Medicine ,Immunology ,2723 Immunology and Allergy ,10177 Dermatology Clinic ,Immunology and Allergy ,610 Medicine & health - Published
- 2022
41. Risk factors for severe reactions in food allergy: Rapid evidence review with meta-analysis
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Turner, Paul J, Arasi, Stefania, Ballmer-Weber, Barbara, Baseggio Conrado, Alessia, Deschildre, Antoine, Gerdts, Jennifer, Halken, Susanne, Muraro, Antonella, Patel, Nandinee, Van Ree, Ronald, de Silva, Debra, Worm, Margitta, Zuberbier, Torsten, and Roberts, Graham
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nervous system ,macromolecular substances - Abstract
This rapid review summarizes the most up to date evidence about the risk factors for severe food-induced allergic reactions. We searched three bibliographic databases for studies published between January 2010 and August 2021. We included 88 studies and synthesized the evidence narratively, undertaking meta-analysis where appropriate. Significant uncertainties remain with respect to the prediction of severe reactions, both anaphylaxis and/or severe anaphylaxis refractory to treatment. Prior anaphylaxis, an asthma diagnosis, IgE sensitization or basophil activation tests are not good predictors. Some molecular allergology markers may be helpful. Hospital presentations for anaphylaxis are highest in young children, yet this age group appears at lower risk of severe outcomes. Risk of severe outcomes is greatest in adolescence and young adulthood, but the contribution of risk taking behaviour in contributing to severe outcomes is unclear. Evidence for an impact of cofactors on severity is lacking, although food-dependent exercise-induced anaphylaxis may be an exception. Some medications such as beta-blockers or ACE inhibitors may increase severity, but appear less important than age as a factor in life-threatening reactions. The relationship between dose of exposure and severity is unclear. Delays in symptom recognition and anaphylaxis treatment have been associated with more severe outcomes. An absence of prior anaphylaxis does not exclude its future risk.
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- 2022
42. INFOGEST Digestion Assay of Raw and Roasted Hazelnuts and Its Impact on Allergens and Their IgE Binding Activity
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Prodić, Ivana, primary, Smiljanić, Katarina, additional, Nagl, Christoph, additional, Ballmer-Weber, Barbara, additional, Hoffmann-Sommergruber, Karin, additional, and Veličković, Tanja Ćirković, additional
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- 2022
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43. Managing food allergy: GA2LEN guideline 2022
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Muraro, Antonella, primary, de Silva, Debra, additional, Halken, Susanne, additional, Worm, Margitta, additional, Khaleva, Ekaterina, additional, Arasi, Stefania, additional, Dunn-Galvin, Audrey, additional, Nwaru, Bright I., additional, De Jong, Nicolette W., additional, Rodríguez Del Río, Pablo, additional, Turner, Paul J., additional, Smith, Pete, additional, Begin, Philippe, additional, Angier, Elizabeth, additional, Arshad, Hasan, additional, Ballmer-Weber, Barbara, additional, Beyer, Kirsten, additional, Bindslev-Jensen, Carsten, additional, Cianferoni, Antonella, additional, Demoulin, Céline, additional, Deschildre, Antoine, additional, Ebisawa, Motohiro, additional, Fernandez-Rivas, Maria Montserrat, additional, Fiocchi, Alessandro, additional, Flokstra-de Blok, Bertine, additional, Gerdts, Jennifer, additional, Gradman, Josefine, additional, Grimshaw, Kate, additional, Jones, Carla, additional, Lau, Susanne, additional, Loh, Richard, additional, Alvaro Lozano, Montserrat, additional, Makela, Mika, additional, Marchisotto, Mary Jane, additional, Meyer, Rosan, additional, Mills, Clare, additional, Nilsson, Caroline, additional, Nowak-Wegrzyn, Anna, additional, Nurmatov, Ulugbek, additional, Pajno, Giovanni, additional, Podestà, Marcia, additional, Poulsen, Lars K., additional, Sampson, Hugh A., additional, Sanchez, Angel, additional, Schnadt, Sabine, additional, Szajewska, Hania, additional, Van Ree, Ronald, additional, Venter, Carina, additional, Vlieg-Boerstra, Berber, additional, Warner, Amena, additional, Wong, Gary, additional, Wood, Robert, additional, Zuberbier, Torsten, additional, Roberts, Graham, additional, Bansal, Priya, additional, Berni–Canani, Roberto, additional, Blumchen, Katharina, additional, Bonertz, Andreas, additional, Bourgoin-Heck, Melisande, additional, Ceylon, Ozlem, additional, Divaret-Chauveau, Amandine, additional, Fleischer, David, additional, Gomez, Maximiliano, additional, Groetch, Marion, additional, Hernandez, Domingo Barber, additional, Hjorth, Betina, additional, Hussey, Lydia Collins, additional, Knulst, André C., additional, Leung, Agnes, additional, Mack, Douglas, additional, Mahler, Vera, additional, Mori, Francesca, additional, Namazova-Baranova, Leyla, additional, Palosuo, Kati, additional, Parisi, Claudio Alberto Salvador, additional, Pastorino, Antonio Carlos, additional, Rudzeviciene, Odilija, additional, Said, Maria, additional, Sawiec, Piotr, additional, Sicherer, Scott, additional, Sato, Sakura, additional, and Zubchenko, Svitlana, additional
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- 2022
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44. Food challenges
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Ballmer-Weber, Barbara K. and Beyer, Kirsten
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- 2018
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45. Is benzyl alcohol a significant contact sensitizer?
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Geier, Johannes, Ballmer-Weber, Barbara, Buhl, Timo, Rieker-Schwienbacher, J, Mahler, Vera, Dickel, Heinrich, Schubert, Steffen, University of Zurich, and Geier, Johannes
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2708 Dermatology ,Kontaktallergie ,Infectious Diseases ,10177 Dermatology Clinic ,610 Medicine & health ,2725 Infectious Diseases ,Dermatology - Abstract
BACKGROUND: Benzyl alcohol is a widely used preservative, solvent and fragrance material. According to published data, it is a rare sensitizer in humans. OBJECTIVES: To identify characteristics and sensitization patterns of patients with positive patch test reactions to benzyl alcohol and to check the reliability of the patch test preparation benzyl alcohol 1% pet. PATIENTS AND METHODS: Retrospective analysis of data from the Information Network of Departments of Dermatology (IVDK), 2010–2019. RESULTS: Of 70 867 patients patch tested with benzyl alcohol 1% pet., 146 (0.21%) showed a positive reaction, most of them (89%) only weakly positive. The number of doubtful and irritant reactions significantly exceeded the number of positive reactions. Reproducibility of positive test reactions was low. Among benzyl alcohol-positive patients, compared to benzyl alcohol-negative patients, there were significantly more patients with leg dermatitis (17.8% vs. 8.6%), more patients aged 40 years or more (81.5% vs. 70.5%) and more patients who were tested because of a suspected intolerance reaction to topical medications (34.9% vs. 16.6%). Concomitant positive reactions were mainly seen to fragrances, preservatives and ointment bases. CONCLUSIONS: Sensitization to benzyl alcohol occurs very rarely, mainly in patients with stasis dermatitis. In view of our results, benzyl alcohol cannot be regarded as a significant contact allergen, and therefore marking it as skin sensitizer 1B and labelling it with H 317 is not helpful.
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- 2022
46. Development and validation of the Food Allergy Severity Score
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Fernández‐Rivas, Montserrat, Gómez García, Ismael, Gonzalo‐Fernández, Alejandro, Fuentes Ferrer, Manuel, Dölle‐Bierke, Sabine, Marco‐Martín, Guadalupe, Ballmer-Weber, Barbara K, et al, University of Zurich, and Fernández‐Rivas, Montserrat
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2403 Immunology ,Immunology ,2723 Immunology and Allergy ,10177 Dermatology Clinic ,Immunology and Allergy ,610 Medicine & health - Published
- 2022
47. Guidelines on the management of IgE-mediated food allergies: S2k-Guidelines of the German Society for Allergology and Clinical Immunology (DGAKI) in collaboration with the German Medical Association of Allergologists (AeDA), the German Professional Association of Pediatricians (BVKJ), the German Allergy and Asthma Association (DAAB), German Dermatological Society (DDG), the German Society for Nutrition (DGE), the German Society for Gastroenterology, Digestive and Metabolic Diseases (DGVS), the German Society for Oto-Rhino-Laryngology, Head and Neck Surgery, the German Society for Pediatric and Adolescent Medicine (DGKJ), the German Society for Pediatric Allergology and Environmental Medicine (GPA), the German Society for Pneumology (DGP), the German Society for Pediatric Gastroenterology and Nutrition (GPGE), German Contact Allergy Group (DKG), the Austrian Society for Allergology and Immunology (Æ-GAI), German Professional Association of Nutritional Sciences (VDOE) and the Association of the Scientific Medical Societies Germany (AWMF)
- Author
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Worm, Margitta, Reese, Imke, Ballmer-Weber, Barbara, Beyer, Kirsten, Bischoff, Stephan C., Classen, Martin, Fischer, Peter J., Fuchs, Thomas, Huttegger, Isidor, Jappe, Uta, Klimek, Ludger, Koletzko, Berthold, Lange, Lars, Lepp, Ute, Mahler, Vera, Niggemann, Bodo, Rabe, Ute, Raithel, Martin, Saloga, Joachim, Schäfer, Christiane, Schnadt, Sabine, Schreiber, Jens, Szépfalusi, Zsolt, Treudler, Regina, Wagenmann, Martin, Watzl, Bernhard, Werfel, Thomas, Zuberbier, Torsten, and Kleine-Tebbe, Jörg
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- 2015
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48. Proposal of 0.5 mg of protein/100 g of processed food as threshold for voluntary declaration of food allergen traces in processed food-A first step in an initiative to better inform patients and avoid fatal allergic reactions : A GA(2)LEN position paper
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Zuberbier, Torsten, Doerr, Tamara, Aberer, Werner, Alvaro, Montserrat, Angier, Elizabeth, Arasi, Stefania, Arshad, Hasan, Ballmer-Weber, Barbara, Bartra, Joan, Beck, Lisa, Begin, Philippe, Bindslev-Jensen, Carsten, Bislimovska, Jovanka, Bousquet, Jean, Brockow, Knut, Bush, Andrew, Cianferoni, Antonella, Cork, Michael J., Custovic, Adnan, Darsow, Ulf, Jong, Nicolette, Deleanu, Diana, Del Giacco, Stefano, Deschildre, Antoine, Galvin, Audrey Dunn, Ebisawa, Motohiro, Fernandez-Rivas, Montserrat, Ferrer, Marta, Fiocchi, Alessandro, van Wijk, Roy Gerth, Gotua, Maia, Grimshaw, Kate, Gruenhagen, Josefine, Heffler, Enrico, Hide, Michihiro, Hoffmann-Sommergruber, Karin, Incorvaia, Cristoforo, Janson, Christer, John, Swen Malte, Jones, Carla, Jutel, Marek, Katoh, Norito, Kendziora, Benjamin, Kinaciyan, Tamar, Knol, Edward, Kurbacheva, Oksana, Lau, Susanne, Loh, Richard, Lombardi, Carlo, Makela, Mika, Marchisotto, Mary Jane, Makris, Michael, Maurer, Marcus, Meyer, Rosan, Mijakoski, Dragan, Minov, Jordan, Mullol, Joaquim, Nilsson, Caroline, Nowak-Wegrzyn, Anna, Nwaru, Bright, I, Odemyr, Mikela, Pajno, Giovanni Battista, Paudel, Sushil, Papadopoulos, Nikolaos G., Renz, Harald, Ricci, Giampaolo, Ring, Johannes, Rogala, Barbara, Sampson, Hugh, Senna, Gianenrico, Sitkauskiene, Brigita, Smith, Peter Kenneth, Stevanovic, Katarina, Stoleski, Sasho, Szajewska, Hania, Tanaka, Akio, Todo-Bom, Ana, Topal, Fatih Alexander, Valovirta, Erkka, Van Ree, Ronald, Venter, Carina, Woehrl, Stefan, Wong, Gary W. K., Zhao, Zuotao, Worm, Margitta, Zuberbier, Torsten, Doerr, Tamara, Aberer, Werner, Alvaro, Montserrat, Angier, Elizabeth, Arasi, Stefania, Arshad, Hasan, Ballmer-Weber, Barbara, Bartra, Joan, Beck, Lisa, Begin, Philippe, Bindslev-Jensen, Carsten, Bislimovska, Jovanka, Bousquet, Jean, Brockow, Knut, Bush, Andrew, Cianferoni, Antonella, Cork, Michael J., Custovic, Adnan, Darsow, Ulf, Jong, Nicolette, Deleanu, Diana, Del Giacco, Stefano, Deschildre, Antoine, Galvin, Audrey Dunn, Ebisawa, Motohiro, Fernandez-Rivas, Montserrat, Ferrer, Marta, Fiocchi, Alessandro, van Wijk, Roy Gerth, Gotua, Maia, Grimshaw, Kate, Gruenhagen, Josefine, Heffler, Enrico, Hide, Michihiro, Hoffmann-Sommergruber, Karin, Incorvaia, Cristoforo, Janson, Christer, John, Swen Malte, Jones, Carla, Jutel, Marek, Katoh, Norito, Kendziora, Benjamin, Kinaciyan, Tamar, Knol, Edward, Kurbacheva, Oksana, Lau, Susanne, Loh, Richard, Lombardi, Carlo, Makela, Mika, Marchisotto, Mary Jane, Makris, Michael, Maurer, Marcus, Meyer, Rosan, Mijakoski, Dragan, Minov, Jordan, Mullol, Joaquim, Nilsson, Caroline, Nowak-Wegrzyn, Anna, Nwaru, Bright, I, Odemyr, Mikela, Pajno, Giovanni Battista, Paudel, Sushil, Papadopoulos, Nikolaos G., Renz, Harald, Ricci, Giampaolo, Ring, Johannes, Rogala, Barbara, Sampson, Hugh, Senna, Gianenrico, Sitkauskiene, Brigita, Smith, Peter Kenneth, Stevanovic, Katarina, Stoleski, Sasho, Szajewska, Hania, Tanaka, Akio, Todo-Bom, Ana, Topal, Fatih Alexander, Valovirta, Erkka, Van Ree, Ronald, Venter, Carina, Woehrl, Stefan, Wong, Gary W. K., Zhao, Zuotao, and Worm, Margitta
- Abstract
Background Food anaphylaxis is commonly elicited by unintentional ingestion of foods containing the allergen above the tolerance threshold level of the individual. While labeling the 14 main allergens used as ingredients in food products is mandatory in the EU, there is no legal definition of declaring potential contaminants. Precautionary allergen labeling such as "may contain traces of" is often used. However, this is unsatisfactory for consumers as they get no information if the contamination is below their personal threshold. In discussions with the food industry and technologists, it was suggested to use a voluntary declaration indicating that all declared contaminants are below a threshold of 0.5 mg protein per 100 g of food. This concentration is known to be below the threshold of most patients, and it can be technically guaranteed in most food production. However, it was also important to assess that in case of accidental ingestion of contaminants below this threshold by highly allergic patients, no fatal anaphylactic reaction could occur. Therefore, we performed a systematic review to assess whether a fatal reaction to 5mg of protein or less has been reported, assuming that a maximum portion size of 1kg of a processed food exceeds any meal and thus gives a sufficient safety margin. Methods MEDLINE and EMBASE were searched until 24 January 2021 for provocation studies and case reports in which one of the 14 major food allergens was reported to elicit fatal or life-threatening anaphylactic reactions and assessed if these occurred below the ingestion of 5mg of protein. A Delphi process was performed to obtain an expert consensus on the results. Results In the 210 studies included, in our search, no reports of fatal anaphylactic reactions reported below 5 mg protein ingested were identified. However, in provocation studies and case reports, severe reactions below 5 mg were reported for the following allergens: eggs, fish, lupin, milk, nuts, peanuts, soy, and se
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- 2022
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49. Supplementary material for:Prodić, I., Smiljanić, K., Nagl, C., Ballmer-Weber, B., Hoffmann-Sommergruber, K.,& Ćirković-Veličković, T.. (2022). INFOGEST Digestion Assay of Raw and Roasted Hazelnuts and Its Impact on Allergens and Their IgE Binding Activity. in Foods MDPI., 11, 2914. https://doi.org/10.3390/foods11182914
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Prodić, Ivana, Smiljanić, Katarina, Nagl, Christoph, Ballmer-Weber, Barbara, Hoffmann-Sommergruber, Karin, Ćirković-Veličković, Tanja, Prodić, Ivana, Smiljanić, Katarina, Nagl, Christoph, Ballmer-Weber, Barbara, Hoffmann-Sommergruber, Karin, and Ćirković-Veličković, Tanja
- Abstract
Most of the food allergens sensitized via the gastrointestinal tract resist thermal treatments and digestion, particularly digestion by pepsin. Roasted hazelnuts are more commonly consumed than raw ones. Since no studies have characterized gastric digestion protein fragments of raw and roasted hazelnuts nor their IgE binding properties, we compared these aspects of raw and roasted hazelnuts’ gastric digesta obtained by INFOGEST protocol. Their electrophoretically resolved profiles were probed with hazelnut allergic patients’ sera in 1D and 2D immunoblots. Electrophoretic profiles demonstrated pepsin digestion of all hazelnut allergens to varying extents. While 2D immunoblots indicated that roasting slightly reduced allergenicity, IgE ELISA with the pool of sera showed a slight significant (10%) increase in IgE binding in both gastric digesta. Cor a 9 isolated from the raw and roasted hazelnuts, characterized by far and near CD, remained stable after roasting, with preserved IgE reactivity. Its immunoreactivity contribution by inhibitory ELISA was noticeable in raw and roasted hazelnut digesta; its activity was slightly stronger in the roasted preparations. Roasting has a visible impact on proteins; however, it did not affect overall IgE reactivity. Gastric digestion slightly increases the overall IgE reactivity in raw and roasted hazelnuts, and may therefore impact the profiles of allergens and their fragments available to interact with the immune system in the small intestine. © 2022 by the authors.
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- 2022
50. Protocol for a systematic review of the diagnostic test accuracy of tests for IgE-mediated food allergy
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Genuneit, Jon, Jayasinghe, Sashini, Riggioni, Carmen, Peters, Rachel Louise, Chu, Derek K., Munblit, Daniel, Boyle, Robert J., Du Toit, George, Skypala, Isabel, Santos, Alexandra F., Akdis, Cezmi A., Alvarez-Perea, Alberto, Lozano, Montserrat Alvaro, Asero, Riccardo, Ballmer-Weber, Barbara, Barber, Domingo, Barni, Simona, Pajno, Giovanni Battista, Beyer, Kirsten, Bindslev-Jensen, Carsten, Brough, Helen, Buyuktiryaki, Betul, de Oliveira, Lucila Camargo Lopes, Cianferoni, Antonella, Chinthrajah, R. Sharon, Parker, Sean N., Giacco, Stefano Del, DunnGalvin, Audrey, Eberlein, Bernadette, Ebisawa, Motohiro, Eigenmann, Philippe, Eiwegger, Thomas, Faber, Margaretha, Fernandez-Rivas, Montserrat, Feeney, Mary, Fisher, Helen, Giovannini, Mattia, Halken, Susanne, Hoffmann-Sommergruber, Karin, Jaumdally, Hannah, Jones, Christina J., Knibb, Rebecca, Knol, Edward, Konstantinou, George N., Krawiec, Marta, Lau, Susanne, Mayorga, Lina, Marques-Mejias, M. Andreina, Meyer, Rosan, Moya, Beatriz, the EAACI Food Allergy Guidelines Expert Group, the EAACI Resear, Genuneit, Jon, Jayasinghe, Sashini, Riggioni, Carmen, Peters, Rachel Louise, Chu, Derek K., Munblit, Daniel, Boyle, Robert J., Du Toit, George, Skypala, Isabel, Santos, Alexandra F., Akdis, Cezmi A., Alvarez-Perea, Alberto, Lozano, Montserrat Alvaro, Asero, Riccardo, Ballmer-Weber, Barbara, Barber, Domingo, Barni, Simona, Pajno, Giovanni Battista, Beyer, Kirsten, Bindslev-Jensen, Carsten, Brough, Helen, Buyuktiryaki, Betul, de Oliveira, Lucila Camargo Lopes, Cianferoni, Antonella, Chinthrajah, R. Sharon, Parker, Sean N., Giacco, Stefano Del, DunnGalvin, Audrey, Eberlein, Bernadette, Ebisawa, Motohiro, Eigenmann, Philippe, Eiwegger, Thomas, Faber, Margaretha, Fernandez-Rivas, Montserrat, Feeney, Mary, Fisher, Helen, Giovannini, Mattia, Halken, Susanne, Hoffmann-Sommergruber, Karin, Jaumdally, Hannah, Jones, Christina J., Knibb, Rebecca, Knol, Edward, Konstantinou, George N., Krawiec, Marta, Lau, Susanne, Mayorga, Lina, Marques-Mejias, M. Andreina, Meyer, Rosan, Moya, Beatriz, and the EAACI Food Allergy Guidelines Expert Group, the EAACI Resear
- Abstract
Background: The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of updating the guidelines on the diagnosis and management of food allergy. The existing guidelines are based on a systematic review of the literature until 30 September 2012. Therefore, a new systematic review must be undertaken to inform the new guidelines. This systematic review aims to assess the accuracy of index tests to support the diagnosis of IgE-mediated food allergy. Methods: The databases Cochrane CENTRAL (Trials), MEDLINE (OVID) and Embase (OVID) will be searched for diagnostic test accuracy studies from 1 October 2012 to 30 June 2021. Inclusion and exclusion criteria will be used to select appropriate studies. Data from these studies will be extracted and tabulated, and then reviewed for risk of bias and applicability using the QUADAS-2 tool. All evaluations will be done in duplicate. Studies with a high risk of bias and low applicability will be excluded. Meta-analysis will be performed if there are three or more studies of the same index test and food. Results: A protocol for the systematic review and meta-analyses is presented and was registered using Prospero prior to commencing the literature search. Discussion: Oral food challenges are the reference standard for diagnosis but involve considerable risks and resources. This protocol for systematic review aims to assess the accuracy of various tests to diagnose food allergy, which can be useful in both clinical and research settings.
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- 2022
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