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2. Asymmetric synthesis of alpha,alpha-difluoro-beta-amino acid derivatives from enantiomerically pure N-tert-butylsulfinimines

Author

Staas, Donnette D., Savage, Kelly L., Homnick, Carl F., Tsou, Nancy N., and Ball, Richard G.

Subjects
Chemistry, Organic -- Research, Amino acids -- Composition, Fluorine compounds, Chemical tests and reagents, Biological sciences, Chemistry
Abstract

Research has been conducted on the fluorinated beta-amino acids. Results indicate that the addition of Reformatsky reagent to alkyl- and aryl-substituted N-tert-butylsulfinimines furnishes beta-tert-butylsulfinamyl-beta-substituted alpha,alpha-difluoroproponiates.

Published
2002

3. Efficient synthesis of the optically active dihydropyrimidinone of a potent [[alpha].sub.1A]-selective adrenoceptor antagonist

Author

Sidler, Daniel R., Barta, Nancy, Li, Wenjie, Hu, Essa, Matty, Louis, Ikemoto, Nori, Campbell, Jeffrey S., Chartrain, Michel, Gbewonyo, Kozo, Boyd, Russell, Corley, Edward G., Ball, Richard G., Larsen, Robert D., and Reider, Paul J.

Subjects
Epinephrine -- Receptors, Organic compounds -- Synthesis, Chemical reactions -- Analysis, Palladium catalysts -- Usage
Abstract

The convergent synthesis of a potent [[alpha].sub.1A]-selective adrenoceptor antagonist is described. Salient features of the synthesis include the enzymatic resolution of a racemic dibydropyrimidinone and the use of a palladium coupling reaction in the synthesis of 2,4'-dipyridyl. Key words: dihydropyrimidinone, enzymatic resolution, palladium coupling.

Published
2002

4. An efficient preparation of vinamidinium hexafluorophosphate salts

Author

Davies, Ian W., Wu, Jimmy, Robbins, Michael A., Ball, Richard G., Larsen, Robert D, Dormer, Peter, Marcoux, Jean-Francois, Reider, Paul J., Tsou, Nancy, Palucki, Michael, and Corley, Edward G.

Subjects
Phosphorus compounds -- Research, Phosphorus compounds -- Chemical properties, Acetic acid -- Research, Acetic acid -- Chemical properties, Biological sciences, Chemistry
Abstract

A method is described where substituted acetic acids or acetyl chlorides are made to react with phosphorus oxychloride in DMF to yield the vinamidinium salts in moderate to excellent crystallized yields. The hexafluorophosphates may provide a general substitution to the more commonly used perchlorate and chloride salts of organic cations.

Published
2000

5. Synthesis of the tetracyclic carbon core of menogaril utilizing the benzannulation reaction of a Fischer carbene complex and an alkyne

Author

Su, Jing, Wulff, William D., and Ball, Richard G.

Subjects
Ring formation (Chemistry) -- Research, Cyclic compounds -- Research, Organic compounds -- Synthesis, Biological sciences, Chemistry
Abstract

A benzannulation reaction of a Fischer carbene complex and an alkyne was utilized in the synthesis of the 2-bromoanthracyclinone derivative that contains the tetracyclic core of menogaril. The parent compound is a 2,5-dimethoxyphenyl carbene complex with an additional functional substituent at the 4 position that corresponds to the nascent substituent at the bromine at position 2 of the final product. A Friedel-Crafts reaction is used to close the last ring in the product.

Published
1998

6. Fusidienol A: a novel Ras farnesyl-protein transferase inhibitor from Phoma sp

Author

Singh, Sheo B., Ball, Richard G., Zink, Deborah L., Monaghan, Richard L., Polishook, Jon D., Sanchez, Manuel, Pelaez, Fernando, Silverman, Keith C., and Lingham, Russell B.

Subjects
Proteins -- Structure, Protein research -- Analysis, Transferases -- Research, Enzyme inhibitors -- Research, Heterocyclic compounds -- Research, Biological sciences, Chemistry
Abstract

Research was conducted to study the isolation, mass spectral fragmentation and biological activity of fusidienol A, the second member of the fusidienol family of inhibitors that possess a tricyclic oxygen-containing heterocycle with a 7/6/6 ring system. Stock cultures of MF 6118 were maintained as mixtures of spores and hyphae in sterile soil. Nuclear magnetic resonance methods were utilized to determine the structure of fusidienol A. A xanthone derivative was identified to be a possible precursor of fusidienol A biogenesis.

Published
1997

7. Nodulisporic acid A, a novel and potent insecticide from a nodulisporium Sp. isolation, structure determination, and chemical transformations

Author

Ondeyka, John G., Helms, Gregory L., Hensens, Otto D., Goetz, Michael L., Zink, Deborah L., Tsipouras, Athanasios, Shoop, Wesley L., Slayton, Lyndia, Dombrowski, Anne W., Polishook, Jon D., Ostlind, Dan A., Tsou, Nancy N., Ball, Richard G., and Singh, Sheo B.

Subjects
Cyclic compounds -- Research, Mycotoxins -- Research, Terpenes -- Research, Insecticides -- Research, Chemistry
Abstract

The structure determination and chemical transformation of nodulisporic acid A was studied to describe its isolation, relative and absolute stereochemistry, biological activity and solution conformation. Spectroscopic evidence and a computerized 2D INADEQUATE analysis were used to examine the structure. Relative stereochemistry were determined through ROESY, NOESY, NOEDS and Jvic evidences. Results show that absolute stereochemistry can be established by applying the Mosher method. The presence of isoprenylated indole moiety was also observed.

Published
1997

8. Dipolar cycloaddition route to diverse analogues of cocaine: the 6- and 7-substituted 3-phenyltropanes

Author

Kozikowski, Alan P., Araldi, Gian Luca, and Ball, Richard G.

Subjects
Cocaine -- Analysis, Organic compounds -- Synthesis, Ring formation (Chemistry) -- Analysis, Biological sciences, Chemistry
Abstract

A novel synthetic route was developed for the synthesis of type I 6- and 7-substituted 3-phenyltropane compounds via pyridinium betaine-based dipolar cycloaddition. The dipolar cycloaddition strategy can be utilized to generate a stereo-defined library of Win-type tropane structures requiring oxidopyridinium betaine. The sequence of reactions will also provide ready access to a new series of tropane derivatives exhibiting substitutions at the 6- or 7-positions and an alpha-stereochemistry.

Published
1997

9. Chemistry and biology of cylindrols: novel inhibitors of ras farnesyl-protein transferase from Cylindrocarpon lucidum

Author

Singh, Sheo B., Ball, Richard G., Bills, Gerald F., Cascales, Carmen, Gibbs, Jackson B., Goetz, Michael A., Hoogsteen, Karst, Jenkins, Rosalind G., Liesch, Jerrold M., Lingham, Russell B., Silverman, Keith C., and Zink, Deborah L.

Subjects
Enzyme inhibitors -- Research, Transferases -- Research, Cyclic compounds -- Research, Biological sciences, Chemistry
Abstract

Bicyclic resocinaldehyde cyclohexanone derivatives were isolated as part of an effort to develop farnesyl-protein transferase inhibitors for the farnesylation of Ras protein. Specifically, cylindrols belonging to the ascochlorin family were isolated from Cylindrocarpon lucidum and characterized with respect to structure-activity relationship. The results demonstrate the dependence of their biological activity on its bicycle, aldehyde and ketone units.

Published
1996

10. Preussomerins and deoxypreussomerins: novel inhibitors of Ras farnesyl-protein transferase

Author

Singh, Sheo B., Zink, Deborah L., Liesch, Jerrold M., Ball, Richard G., Goetz, Michael A., Bolessa, Evon A., Giacobbe, Robert A., Silverman, Keith C., Bills, Gerald F., Pelaez, Fernando, Cascales, Carmen, Gibbs, Jackson B., and Lingham, Russell B.

Subjects
Transferases -- Research, Enzyme inhibitors -- Research, Structure-activity relationship (Pharmacology) -- Research, Biological sciences, Chemistry
Abstract

Extraction with methyl ethyl ketone and chromatographic techniques help isolate various preussomerins and deoxypreussomerins, inhibitors of farnesyl-protein transferase (FPTase), from the fermentation broth of a dung-inhibiting coelomycetous fungus from Chaco Province, Argentina. Electron impact mass-spectral analysis helps determine the molecular weights and molecular formulae of these compounds and NMR experiments help analyze the structures. Preussomerin undergoes hydrogenation and exhibits Michael reactions. Examination of the structure-activity relationship reveals that 1, 2-dioxygen unit of preussomerin is essential for the inhibition of FPTase activity.

Published
1994

11. Three-component intramolecular two-alkyne annulations of Fischer carbene complexes: new strategies for steroid synthesis

Author

Bao, Jianming, Wulff, William D., Dragisich, Vera, Wenglowsky, Steve, and Ball, Richard G.

Subjects
Phenols -- Research, Heterocyclic compounds -- Analysis, Diels-Alder reaction -- Analysis, Chemistry
Abstract

Three-component intramolecular two-alkyne annulations of chromium and tungsten carbene complexes help prepare tricyclic phenols. The nature of metal, solvent and ring size influence tricyclic phenol formation. Tandem coupling of three-component two-alkyne annulation and Diels Alder reaction of carbene complexes yields a tetracyclic ring system of steroids. Use of this method enables one-pot preparation of all four rings of a steroid ring system and also produce nonaromatic steroidal ring systems.

Published
1994

12. Metal-catalyzed cyclopropene rearrangements for benzannulation: evaluation of an anthraquinone synthesis pathway and reevaluation of the parallel approach via carbene-chromium complexes

Author

Semmelhack, M.F., Ho, Suzzy, Cohen, D., Steigerwald, M., Lee, M.C., Lee, G., Gilbert, Adam M., Wulff, William D., and Ball, Richard G.

Subjects
Cyclic compounds -- Analysis, Rearrangements (Chemistry) -- Analysis, Anthraquinones -- Analysis, Chemistry
Abstract

Metal-catalyzed ring opening of 3-arylcyclopropenes with Cr(CO)6 and Mo(CO)6 produces naphthols via a reaction pathway involving a metal-complexed vinyl carbene intermediate similar to the benzannulation reaction between arylcarbenes and alkynes. Substitution at C-3 influences reaction feasibility. As steric size increases, reactivity decreases. Rearrangement of 3-(1, 4-dimethoxy-2-naphthyl)cyclopropane produces a phenanthrene, indicating the error associated with anthraquinone synthesis through a naphthylcarbene-chromium/alkyne reaction.

Published
1994

13. Absolute stereochemistry of the squalene synthase inhibitor zaragozic acid C

Author

Santini, Conrad, Ball, Richard G., and Berger, Gregory D.

Subjects
Acids -- Analysis, X-ray crystallography -- Analysis, Biological sciences, Chemistry
Abstract

Crystallographic analysis of zaragozic acid C revealed the stereochemical similarity of its C1 chain to that of zaragozic acid A. Zaragozic acid C differs from zaragozic A and B in its lipophilic side chains and requires a selective removal method to remove C5 ester. Deacylation of the acid residue is possible by using olefinc bond.

Published
1994

14. Total synthesis and determination of the absolute configuration of epibatidine

Author

Fletcher, Stephen R., Baker, Raymond, Chambers, Mark S., Herbert, Richard H., Hobbs, Sarah C., Thomas, Steven R., Verrier, Hugh M., Watt, Alan P., and Ball, Richard G.

Subjects
Alkaloids -- Research, Chemical structure -- Analysis, Biological sciences, Chemistry
Abstract

A novel synthetic process involving the reaction of 5-lithio-2-chloropyridine and (+)- and (-)-N-BOC-7-azabicyclo(2.2.1)heptan-2-one leads to the formation of epibatidine. X-ray crystal structure study reveals the configuration to be 1R, 2R,4S. The pyridyl group at C-2 is present in the C-2 exo-orientation configuration.

Published
1994

16. Synthesis, molecular modeling, 2-D NMR, and biological evaluation of ILV mimics as potential modulators of protein kinase C

Author

Kozikowski, Alan P., Ma, Dawei, Pang, Yuan-Ping, Shum, Patrick, Likic, Vladimir, Mishra, Prasanna K., Macura, Slobodan, Basu, Alakananda, Lazo, John S., and Ball, Richard G.

Subjects
Protein kinases -- Research, Chemistry
Abstract

A study was done on ILV mimics as potential modulators of protein kinase C (PKC). Results show that analogues of ILV are unable to modulate PKC activity which excludes the possibility that a benzene ring can serve as a surrogate of the indole ring of ILV. These findings suggest that the nine-membered lactam ring moiety of ILV in an (ILV) sofa conformation does not adequately determine PKC activation.

Published
1993

17. Zaragozic acid A, a potent inhibitor of squalene synthase: initial chemistry and absolute stereochemistry

Author

Wilson, Kenneth E., Burk, Robert M., Biftu, Tesfaye, Ball, Richard G., and Hoogsteen, Karst

Subjects
Enzyme inhibitors -- Research, Biological sciences, Chemistry
Abstract

The stereochemistry of zaragozic acid A, a squalene synthase inhibitor, was investigated in an effort to fully understand its structure as an initial step in the search for a synthetic pathway for the inhibitor. Selective scission of either an acetyl or a 4,6-dimethyl-2-octenoyl residue was undertaken to study the core of the molecule. Further, it was shown that the individual carboxyl groups can be manipulated selectively.

Published
1992

18. Reactions of perfluoromethyl-substituted cyclopolyphosphines with zerovalent group 10 metal complexes: crystal and molecular structure of a complex with a coordinated diphosphene, (Pd(eta2-CF3P double bonds PCF3)(PPh3)2)

Author

Phillips, Ian G., Ball, Richard G., and Cavell, Ronald G.

Subjects
Coordination compounds -- Analysis, Phosphorus compounds -- Analysis, Chemical structure -- Analysis, Chemistry
Abstract

(Pd(eta squared-CF3P double bond PCF3)(PPh3)2) is a palladium diphosphene complex, formed by the reaction between a trifluoromethyl-substituted cyclophosphine ((CF3P)4,5) and a zerovalent tertiary phosphene supported palladium. Diphosphene complexes are formed whenever solutions of (CF3P)4,5 with toluene or MLn (M = platinum, n=3) are refluxed for about three hours. NMR spectroscopy shows the coordinated and ring-opened intermediates formed initially by 1,3 coordination of diphosphenes.

Published
1992

20. Mitsunobu-like processes with a novel triphenylphosphine-cyclic sulfamide betaine

Author

Castro, Jose L., Matassa, Victor G., and Ball, Richard G.

Subjects
Organophosphorus compounds -- Research, Biological sciences, Chemistry
Abstract

The reaction between triphenylphosphine and 3, 3-dimethyl-1,2,5-thiadiazolidine 1,1-dioxide produces an adduct that is a stable source of the (Ph3P)(super plus) species. This adduct increases the coupling between alcohols and carboxylic or nitrogen acids. This reaction yields information about the Mitsunobu reaction mechanism.

Published
1994

21. Stereoselection in the chromium-mediated intramolecular (2 + 2) cycloadditions of vinyl ketenes and alkenes

Author

Kim, Oak K., Wulff, William D., Weiqin Jiang, and Ball, Richard G.

Subjects
Ring formation (Chemistry) -- Analysis, Vinyl polymers -- Analysis, Olefins -- Analysis, Chromium -- Research, Biological sciences, Chemistry
Abstract

Cyclopropanes and cyclobutanes of various kinds are formed when chiral enynes interact with Fischer carbene complexes. A carbene ligand in shifted intramolecularly to an alkene to form various cyclopropane derivations. A vinyl ketene complex is produced when a CO2 is added in a migratory manner for an alternative product. A form of cyclobutane is also formed with the introduction of the ketene and the alkene. The prominence of cyclobutanes as cultured intermediates reveals the association between this interaction and the introduction of the metal free ketene in an intramolecular cyclic manner.

Published
1993

22. A spectroscopic and crystallographic investigation of the structure and hydrogen bonding properties of the chiral leukotriene antagonist MK-679 as compared to its racemate MK-571

Author

Ball, Richard G. and Baum, Mary W.

Subjects
Leukotrienes -- Analysis, Chemical inhibitors -- Analysis, Hydrogen bonding -- Research, Biological sciences, Chemistry
Abstract

The crystal structure of the chiral leukotriene antagonist MK-679 has been determined. With an empirical formula of C26H27ClN2O3S2, its molecularweight comes to 515.10. The chains along the b axis are linked by hydrogen bonds while the extended pi-systems interact through pi-to-pi stacking. The spectra of MK-679 are compared with those of its racemate MK-571 and their spectra correlated with their crystal structure. The differences in their spectra are large enough to distinguish each of the crystalline forms.

Published
1992

23. Isolation and structure elucidation of parnafungins, antifungal natural products that inhibit mRNA polyadenylation

Author

Parish, Craig A., Smith, Scott K., Calati, Kathleen, Zink, Deborah, Wilson, Kenneth, Roemer, Terry, Bo Jiang, Deming Xu, Bills, Gerald, Platas, Gonzalo, Pelaez, Fernando, Diez, Maria Teresa, Tsou, Nancy, McKeown, Arlene E., Ball, Richard G., Powles, Mary Ann, Lai Yeung, Liberator, Paul, and Harris, Guy

Subjects
Adenosine -- Chemical properties, Antifungal agents -- Chemical properties, Antifungal agents -- Structure, Messenger RNA -- Chemical properties, Chemistry
Abstract

The article explains the structure and the isolation of parnafungins, the antifungal natural products that inhibit mRNA polyadenylation. The fungal polyadenosine polymerase is shown to act as the biochemical target of these natural products.

Published
2008

24. Lead optimization of 4,4-biaryl piperidine amides as γ-secretase inhibitors

Author

Close, Joshua, Heidebrecht, Richard, Jr., Hendrix, John, Li, Chaomin, Munoz, Ben, Surdi, Laura, Kattar, Solomon, Tempest, Paul, Moses, Paul, Geng, Xiaoliu, Hughes, Bethany, Smotrov, Nadya, Moxham, Chris, Chapnick, Jennifer, Kariv, Ilona, Nikov, George, Burke, Julie Elizabeth, Deshmukh, Sujal, Jeliazkova-Mecheva, Valentina, Leach, John Kevin, Diaz, Damaris, Xu, Lin, Yang, Ziping, Kwei, Gloria, Moy, Lily, Shah, Sanjiv, Tanga, Flobert, Kenefic, Candia, Savage, Dan, Shearman, Mark, Ball, Richard G., McNevin, Michael J., Markarewicz, Amanda, and Miller, Thomas

Published
2012
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26. Careful Navigation of the Crystallographic Landscape of MK-8970: A Racemic Acetal Carbonate Prodrug of Raltegravir

Author

Tsou, Nancy, primary, Shultz, C. Scott, additional, Andreani, Teresa, additional, Ball, Richard G., additional, Brunskill, Andrew, additional, Balsells, Jaume, additional, Cohen, Ryan D., additional, DaSilva, Jimmy, additional, Li, Jing, additional, Reamer, Robert A., additional, de Lera Ruiz, Manuel, additional, Variankaval, Narayan, additional, Varsolona, Richard J., additional, Yasuda, Nobuyoshi, additional, and York, Gregory, additional

Published
2015
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27. Design of a novel pyrrolidine scaffold utilized in the discovery of potent and selective human β 3 adrenergic receptor agonists

Author

Morriello, Gregori J., Wendt, Harvey R., Bansal, Alka, Salvo, Jerry Di, Feighner, Scott, He, Jiafang, Hurley, Amanda L., Hreniuk, Donna L., Salituro, Gino M., Reddy, Marat Vijay, Galloway, Sheila M., McGettigan, Katherine K., Laws, George, McKnight, Crystal, Doss, George A., Tsou, Nancy N., Black, Regina M., Morris, Judy, Ball, Richard G., Sanfiz, Anthony T., Streckfuss, Eric, Struthers, Mary, and Edmondson, Scott D.

Published
2011
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28. Discovery of potent, selective, and orally bioavailable 3 H-spiro[isobenzofuran-1,4′-piperidine] based melanocortin subtype-4 receptor agonists

Author

Guo, Liangqin, Ye, Zhixiong, Liu, Jian, He, Shuwen, Bakshi, Raman K., Sebhat, Iyassu K., Dobbelaar, Peter H., Hong, Qingmei, Jian, Tianying, Dellureficio, James P., Tsou, Nancy N., Ball, Richard G., Weinberg, David H., MacNeil, Tanya, Tang, Rui, Tamvakopoulos, Constantin, Peng, Qianping, Chen, Howard Y., Chen, Airu S., Martin, William J., MacIntyre, D. Euan, Strack, Alison M., Fong, Tung M., Wyvratt, Matthew J., and Nargund, Ravi P.

Published
2010
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29. Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist

Author

He, Shuwen, Ye, Zhixiong, Dobbelaar, Peter H., Sebhat, Iyassu K., Guo, Liangqin, Liu, Jian, Jian, Tianying, Lai, Yingjie, Franklin, Christopher L., Bakshi, Raman K., Dellureficio, James P., Hong, Qingmei, Tsou, Nancy N., Ball, Richard G., Cashen, Doreen E., Martin, William J., Weinberg, David H., MacNeil, Tanya, Tang, Rui, Tamvakopoulos, Constantin, Peng, Qianping, Miller, Randy R., Stearns, Ralph A., Chen, Howard Y., Chen, Airu S., Strack, Alison M., Fong, Tung M., MacIntyre, D. Euan, Wyvratt, Matthew J., Jr., and Nargund, Ravi P.

Published
2010
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31. Diamine Derivatives as Novel Small-Molecule, Potent, and Subtype-Selective Somatostatin SST3 Receptor Agonists

Author

Li, Derun, primary, Wu, Zhicai, additional, Yu, Yang, additional, Ball, Richard G., additional, Guo, Liangqin, additional, Sherer, Edward, additional, He, Shuwen, additional, Hong, Qingmei, additional, Lai, Zhong, additional, Qi, Hongbo, additional, Truong, Quang, additional, Yang, David X., additional, Chicchi, Gary G., additional, Tsao, Kwei-Lan, additional, Trusca, Dorina, additional, Trujillo, Maria, additional, Pachanski, Michele, additional, Eiermann, George J., additional, Howard, Andrew D., additional, Zhou, Yun-Ping, additional, Zhang, Bei B., additional, Nargund, Ravi P., additional, and Hagmann, William K., additional

Published
2014
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33. 2-[(3aR,4R,5S,7aS)-5-{(1S)-1-[3,5-Bis(trifluoromethyl)phenyl]-2-hydroxyethoxy}-4-(2-methylphenyl)octahydro-2H-isoindol-2-yl]-1,3-oxazol-4(5H)-one: A Potent Human NK1 Receptor Antagonist with Multiple Clearance Pathways

Author

Kassick, Andrew J., primary, Jiang, Jinlong, additional, Bunda, Jaime, additional, Wilson, David, additional, Bao, Jianming, additional, Lu, Huagang, additional, Lin, Peter, additional, Ball, Richard G., additional, Doss, George A., additional, Tong, Xinchun, additional, Tsao, Kwei-Lan C., additional, Wang, Hong, additional, Chicchi, Gary, additional, Karanam, Bindhu, additional, Tschirret-Guth, Richard, additional, Samuel, Koppara, additional, Hora, Donald F., additional, Kumar, Sanjeev, additional, Madeira, Maria, additional, Eng, Waisi, additional, Hargreaves, Richard, additional, Purcell, Mona, additional, Gantert, Liza, additional, Cook, Jacquelyn, additional, DeVita, Robert J., additional, and Mills, Sander G., additional

Published
2013
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37. Asymmetric Synthesis of a Glucagon Receptor Antagonist via Friedel–Crafts Alkylation of Indole with Chiral α-Phenyl Benzyl Cation

Author

Chung, John Y. L., primary, Steinhuebel, Dietrich, additional, Krska, Shane W., additional, Hartner, Fred W., additional, Cai, Chaoxian, additional, Rosen, Jonathan, additional, Mancheno, Danny E., additional, Pei, Tao, additional, DiMichele, Lisa, additional, Ball, Richard G., additional, Chen, Cheng-yi, additional, Tan, Lushi, additional, Alorati, Antony D., additional, Brewer, Sarah E., additional, and Scott, Jeremy P., additional

Published
2012
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38. The Discovery of MK-4256, a Potent SSTR3 Antagonist as a Potential Treatment of Type 2 Diabetes

Author

He, Shuwen, primary, Ye, Zhixiong, additional, Truong, Quang, additional, Shah, Shrenik, additional, Du, Wu, additional, Guo, Liangqin, additional, Dobbelaar, Peter H., additional, Lai, Zhong, additional, Liu, Jian, additional, Jian, Tianying, additional, Qi, Hongbo, additional, Bakshi, Raman K., additional, Hong, Qingmei, additional, Dellureficio, James, additional, Pasternak, Alexander, additional, Feng, Zhe, additional, deJesus, Reynalda, additional, Yang, Lihu, additional, Reibarkh, Mikhail, additional, Bradley, Scott A., additional, Holmes, Mark A., additional, Ball, Richard G., additional, Ruck, Rebecca T., additional, Huffman, Mark A., additional, Wong, Frederick, additional, Samuel, Koppara, additional, Reddy, Vijay B., additional, Mitelman, Stan, additional, Tong, Sharon X., additional, Chicchi, Gary G., additional, Tsao, Kwei-Lan, additional, Trusca, Dorina, additional, Wu, Margaret, additional, Shao, Qing, additional, Trujillo, Maria E., additional, Eiermann, George J., additional, Li, Cai, additional, Zhang, Bei B., additional, Howard, Andrew D., additional, Zhou, Yun-Ping, additional, Nargund, Ravi P., additional, and Hagmann, William K., additional

Published
2012
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39. Synthesis of Antifungal Glucan Synthase Inhibitors from Enfumafungin

Author

Zhong, Yong-Li, primary, Gauthier, Donald R., additional, Shi, Yao-Jun, additional, McLaughlin, Mark, additional, Chung, John Y. L., additional, Dagneau, Philippe, additional, Marcune, Benjamin, additional, Krska, Shane W., additional, Ball, Richard G., additional, Reamer, Robert A., additional, and Yasuda, Nobuyoshi, additional

Published
2012
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40. Cover Picture: Discovery of [(2R,5R)-5-{[(5-Fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): A Dual Orexin Receptor Antagonist with Potent Sleep-Promoting Properties (ChemMedChem 3/2012)

Author

Coleman, Paul J., primary, Schreier, John D., additional, Cox, Christopher D., additional, Breslin, Michael J., additional, Whitman, David B., additional, Bogusky, Michael J., additional, McGaughey, Georgia B., additional, Bednar, Rodney A., additional, Lemaire, Wei, additional, Doran, Scott M., additional, Fox, Steven V., additional, Garson, Susan L., additional, Gotter, Anthony L., additional, Harrell, C. Meacham, additional, Reiss, Duane R., additional, Cabalu, Tamara D., additional, Cui, Donghui, additional, Prueksaritanont, Thomayant, additional, Stevens, Joanne, additional, Tannenbaum, Pamela L., additional, Ball, Richard G., additional, Stellabott, Joyce, additional, Young, Steven D., additional, Hartman, George D., additional, Winrow, Christopher J., additional, and Renger, John J., additional

Published
2012
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42. Discovery of [(2R,5R)-5-{[(5-Fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): A Dual Orexin Receptor Antagonist with Potent Sleep-Promoting Properties

Author

Coleman, Paul J., primary, Schreier, John D., additional, Cox, Christopher D., additional, Breslin, Michael J., additional, Whitman, David B., additional, Bogusky, Michael J., additional, McGaughey, Georgia B., additional, Bednar, Rodney A., additional, Lemaire, Wei, additional, Doran, Scott M., additional, Fox, Steven V., additional, Garson, Susan L., additional, Gotter, Anthony L., additional, Harrell, C. Meacham, additional, Reiss, Duane R., additional, Cabalu, Tamara D., additional, Cui, Donghui, additional, Prueksaritanont, Thomayant, additional, Stevens, Joanne, additional, Tannenbaum, Pamela L., additional, Ball, Richard G., additional, Stellabott, Joyce, additional, Young, Steven D., additional, Hartman, George D., additional, Winrow, Christopher J., additional, and Renger, John J., additional

Published
2012
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43. Discovery of Benzodiazepine Sulfonamide-Based Bombesin Receptor Subtype 3 Agonists and Their Unusual Chirality

Author

Liu, Ping, primary, Lanza, Thomas J., additional, Chioda, Marc, additional, Jones, Carrie, additional, Chobanian, Harry R., additional, Guo, Yan, additional, Chang, Linda, additional, Kelly, Theresa M., additional, Kan, Yanqing, additional, Palyha, Oksana, additional, Guan, Xiao-Ming, additional, Marsh, Donald J., additional, Metzger, Joseph M., additional, Ramsay, Katie, additional, Wang, Sheng-Ping, additional, Strack, Alison M., additional, Miller, Randy, additional, Pang, Jianmei, additional, Lyons, Kathy, additional, Dragovic, Jasminka, additional, Ning, Jian G., additional, Schafer, Wes A., additional, Welch, Christopher J., additional, Gong, Xiaoyi, additional, Gao, Ying-Duo, additional, Hornak, Viktor, additional, Ball, Richard G., additional, Tsou, Nancy, additional, Reitman, Marc L., additional, Wyvratt, Matthew J., additional, Nargund, Ravi P., additional, and Lin, Linus S., additional

Published
2011
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44. Design of a novel pyrrolidine scaffold utilized in the discovery of potent and selective human β3 adrenergic receptor agonists

Author

Morriello, Gregori J., primary, Wendt, Harvey R., additional, Bansal, Alka, additional, Salvo, Jerry Di, additional, Feighner, Scott, additional, He, Jiafang, additional, Hurley, Amanda L., additional, Hreniuk, Donna L., additional, Salituro, Gino M., additional, Reddy, Marat Vijay, additional, Galloway, Sheila M., additional, McGettigan, Katherine K., additional, Laws, George, additional, McKnight, Crystal, additional, Doss, George A., additional, Tsou, Nancy N., additional, Black, Regina M., additional, Morris, Judy, additional, Ball, Richard G., additional, Sanfiz, Anthony T., additional, Streckfuss, Eric, additional, Struthers, Mary, additional, and Edmondson, Scott D., additional

Published
2011
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45. Discovery of potent, selective, and orally bioavailable 3H-spiro[isobenzofuran-1,4′-piperidine] based melanocortin subtype-4 receptor agonists

Author

Guo, Liangqin, primary, Ye, Zhixiong, additional, Liu, Jian, additional, He, Shuwen, additional, Bakshi, Raman K., additional, Sebhat, Iyassu K., additional, Dobbelaar, Peter H., additional, Hong, Qingmei, additional, Jian, Tianying, additional, Dellureficio, James P., additional, Tsou, Nancy N., additional, Ball, Richard G., additional, Weinberg, David H., additional, MacNeil, Tanya, additional, Tang, Rui, additional, Tamvakopoulos, Constantin, additional, Peng, Qianping, additional, Chen, Howard Y., additional, Chen, Airu S., additional, Martin, William J., additional, MacIntyre, D. Euan, additional, Strack, Alison M., additional, Fong, Tung M., additional, Wyvratt, Matthew J., additional, and Nargund, Ravi P., additional

Published
2010
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47. Discovery ofN-[(4R)-6-(4-Chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-carboxamide (MK-5596) as a Novel Cannabinoid-1 Receptor (CB1R) Inverse Agonist for the Treatment of Obesity

Author

Yan, Lin, primary, Huo, Pei, additional, Debenham, John S., additional, Madsen-Duggan, Christina B., additional, Lao, Julie, additional, Chen, Richard Z., additional, Xiao, Jing Chen, additional, Shen, Chun-Pyn, additional, Stribling, D. Sloan, additional, Shearman, Lauren P., additional, Strack, Alison M., additional, Tsou, Nancy, additional, Ball, Richard G., additional, Wang, Junying, additional, Tong, Xinchun, additional, Bateman, Thomas J., additional, Reddy, Vijay B. G., additional, Fong, Tung M., additional, and Hale, Jeffrey J., additional

Published
2010
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50. 1-Sulfonyl-4-acylpiperazines as Selective Cannabinoid-1 Receptor (CB1R) Inverse Agonists for the Treatment of Obesity

Author

Vachal, Petr, primary, Fletcher, Joan M., additional, Fong, Tung M., additional, Huang, Cathy C. R.-R., additional, Lao, Julie, additional, Xiao, Jing C., additional, Shen, Chun-Pyn, additional, Strack, Alison M., additional, Shearman, Lauren, additional, Stribling, Sloan, additional, Chen, Richard Z., additional, Frassetto, Andrea, additional, Tong, Xinchun, additional, Wang, Junying, additional, Ball, Richard G., additional, Tsou, Nancy N., additional, Hickey, Gerard J., additional, Thompson, Donald F., additional, Faidley, Terry D., additional, Nicolich, Susan, additional, Achanfuo-Yeboah, Joana, additional, Hora, Donald F., additional, Hale, Jeffrey J., additional, and Hagmann, William K., additional

Published
2009
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