Isolation and structure elucidation of parnafungins, antifungal natural products that inhibit mRNA polyadenylation

Authors :: Parish, Craig A.
Smith, Scott K.
Calati, Kathleen
Zink, Deborah
Wilson, Kenneth
Roemer, Terry
Bo Jiang
Deming Xu
Bills, Gerald
Platas, Gonzalo
Pelaez, Fernando
Diez, Maria Teresa
Tsou, Nancy
McKeown, Arlene E.
Ball, Richard G.
Powles, Mary Ann
Lai Yeung
Liberator, Paul
Harris, Guy
Source :: Journal of the American Chemical Society. June 4, 2008, Vol. 130 Issue 22, 7060-7066
Publication Year :: 2008
Abstract: The article explains the structure and the isolation of parnafungins, the antifungal natural products that inhibit mRNA polyadenylation. The fungal polyadenosine polymerase is shown to act as the biochemical target of these natural products.

Subjects :: Adenosine -- Chemical properties
Antifungal agents -- Chemical properties
Antifungal agents -- Structure
Messenger RNA -- Chemical properties
Chemistry

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