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1. HIV infection increases the risk of acquiring Plasmodium vivax malaria: a 4-year cohort study in the Brazilian Amazon HIV and risk of vivax malaria

Author

Guerra, Cecilia Victoria Caraballo, da Silva, Bernardo Maia, Müller, Pia, Baia-da-Silva, Djane Clarys, Moura, Marco Antônio Saboia, Araújo, José Deney Alves, Silva, Juan Carlo Santos e, Silva-Neto, Alexandre Vilhena, da Silva Balieiro, Antonio Alcirley, da Costa-Martins, André Guilherme, Melo, Gisely Cardoso, Val, Fernando, Bassat, Quique, Nakaya, Helder I., Martinez-Espinosa, Flor Ernestina, Lacerda, Marcus, Sampaio, Vanderson Souza, and Monteiro, Wuelton

Published
2022
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2. Prevalence of glucose 6-phosphate dehydrogenase deficiency in highly malaria-endemic municipalities in the Brazilian Amazon: A region-wide screening study

Author

Nascimento, Joabi Rocha, Brito-Sousa, Jose Diego, Almeida, Anne Cristine Gomes, Melo, Marly M, Costa, Monica Regina Farias, Barbosa, Laila Rowena Albuquerque, Ramos, Reinaldo Nery, Silva-Neto, Alexandre Vilhena, Balieiro, Patricia Carvalho da Silva, Figueiredo, Erick Frota Gomes, Silva, Emanuelle Lira, Baia-da-Silva, Djane Clarys, Bassat, Quique, Romero, Gustavo, Melo, Gisely Cardoso, Sampaio, Vanderson Souza, Lacerda, Marcus, and Monteiro, Wuelton

Published
2022
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3. Does the Presence or a High Titer of Yellow Fever Virus Antibodies Interfere with Pregnancy Outcomes in Women with Zika Virus Infection?

Author

Piauilino, Isa Cristina Ribeiro, primary, Souza, Raillon Keven dos Santos, additional, Lima, Maurício Teixeira, additional, Rodrigues, Yanka Karolinna Batista, additional, da Silva, Luís Felipe Alho, additional, Gouveia, Ayrton Sena, additional, Neto, Alexandre Vilhena da Silva, additional, Chaves, Bárbara Aparecida, additional, Alecrim, Maria das Graças Costa, additional, de Menezes, Camila Helena Aguiar Bôtto, additional, Castilho, Márcia da Costa, additional, Baia-da-Silva, Djane Clarys, additional, and Espinosa, Flor Ernestina Martinez, additional

Published
2023
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4. Should we care about Plasmodium vivax and HIV co-infection? A systematic review and a cases series from the Brazilian Amazon

Author

Del-Tejo, Paola López, Cubas-Vega, Nadia, Caraballo-Guerra, Cecilia, da Silva, Bernardo Maia, da Silva Valente, Jefferson, Sampaio, Vanderson Souza, Baia-da-Silva, Djane Clarys, Castro, Daniel Barros, Martinez-Espinosa, Flor Ernestina, Siqueira, André Machado, Lacerda, Marcus Vinícius Guimarães, Monteiro, Wuelton Marcelo, and Val, Fernando

Published
2021
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5. Clinical and Acoustic Alterations of Swallowing in Children Exposed to Zika Virus during Pregnancy in a Cohort in Amazonas, Brazil: A Case Series Study.

Author

Rodrigues, Cristina de Souza, Souza, Raillon Keven Santos, Rocha Neto, Cosmo Vieira, Otani, Rodrigo Haruo, Batista, Daniel de Medeiros, Maia, Ana Karla Nelson de Oliveira, Filho, Kleber Pinheiro de Oliveira, Andrade, Thais Dourado de, Andrade Almeida, Emmilyn de, Maciel, Luiz Henrique Gonçalves, Castro, Lucíola de Fátima Albuquerque Almeida Peixoto, Abtibol-Bernardino, Marília Rosa, Baia-da-Silva, Djane Clarys, Benzecry, Silvana Gomes, Castilho, Marcia da Costa, Martínez-Espinosa, Flor Ernestina, Alecrim, Maria das Graças Costa, Santos, Rosane Sampaio, and Botto-Menezes, Camila

Subjects
DEGLUTITION, ZIKA virus infections, ZIKA virus, SOFT palate, HARD palate, BOLUS (Digestion), BREAST milk
Abstract

Oropharyngeal dysphagia (OD) is a swallowing disorder that involves difficulty in safely passing the food bolus from the oral cavity to the stomach. OD is a common problem in children with congenital Zika virus syndrome (CZS). In this case series, we describe the clinical and acoustic alterations of swallowing in children exposed to the Zika virus during pregnancy in a cohort from Amazonas, Brazil. From July 2019 to January 2020, 22 children were evaluated, 6 with microcephaly and 16 without microcephaly. The mean age among the participants was 35 months (±4.6 months). All children with microcephaly had alterations in oral motricity, mainly in the lips and cheeks. Other alterations were in vocal quality, hard palate, and soft palate. Half of the children with microcephaly showed changes in cervical auscultation during breast milk swallowing. In children without microcephaly, the most frequently observed alteration was in lip motricity, but alterations in auscultation during the swallowing of breast milk were not observed. Regarding swallowing food of a liquid and pasty consistency, the most frequent alterations were incomplete verbal closure, increased oral transit time, inadequacy in capturing the spoon, anterior labial leakage, and increased oral transit time. Although these events are more frequent in microcephalic children, they can also be seen in non-microcephalic children, which points to the need for an indistinct evaluation of children exposed in utero to ZIKV. [ABSTRACT FROM AUTHOR]

Published
2023
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7. Sequelae and mortality in patients with HIV/AIDS and Progressive Multifocal Leukoencephalopathy: Systematic review and case series in the Brazilian Amazon

Author

Valente, Jefferson, primary, Del-Tejo, Paola López, additional, Cubas-Vega, Nadia Carolina, additional, Rodrigues, Maria Gabriela de Almeida, additional, de Barros, Francisco Railson Bispo, additional, Alexandre, Márcia Araújo, additional, Arêas, Guilherme Peixoto Tinoco, additional, Bastos, Michele, additional, Pinto, Sérgio Damasceno, additional, Barros, Camila Miriam S. S., additional, Marinho, Eveny Perlize, additional, Mello, Sabrina, additional, Ferreira, Ewerton, additional, Aprigio, Valderjane, additional, Monte, Rossiclea Lins, additional, Sampaio, Vanderson, additional, Lacerda, Marcus, additional, Baia-da-Silva, Djane Clarys, additional, and Val, Fernando, additional

Published
2023
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8. Rosette formation by Plasmodium vivax gametocytes favors the infection in Anopheles aquasalis

Author

Salazar Alvarez, Luis Carlos, primary, Carneiro Barbosa, Vanessa, additional, Vera Lizcano, Omaira, additional, Baia da Silva, Djane Clarys, additional, Gonçalves Santana, Rosa Amélia, additional, Fabbri, Camila, additional, Paoluci Pimenta, Paulo Filemon, additional, Monteiro, Wuelton Marcelo, additional, Albrecht, Letusa, additional, Guimarães de Lacerda, Marcus Vinicius, additional, Trindade Maranhão Costa, Fabio, additional, and Costa Pinto Lopes, Stefanie, additional

Published
2023
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9. Detection of HPV DNA in vaginal samples self-collected by women living with HIV treated through the Brazilian public health system: Prevalence and analysis of risk factors

Author

Silveira, Mariângela Freitas da, primary, Buffarini, Romina, additional, Gaspar, Pâmela Cristina, additional, Machado, Hanalydia de Melo, additional, Bazzo, Maria Luiza, additional, Scherer, Aline, additional, Colusso, Álvaro Luis, additional, Travassos, Ana Gabriela Álvares, additional, Arakaki-Sanchez, Denise, additional, Baia-da-Silva, Djane Clarys, additional, Oliveira, Eduardo Campos de, additional, Zago, Isabella Ribeiro, additional, Moura, Marcos de Assis, additional, Lacerda, Marcus Vinicius Guimarães de, additional, Martins, Simone Murta, additional, Reuter, Tânia, additional, Pinto, Valdir Monteiro, additional, Perini, Waltesia, additional, Pereira, Gerson Fernando Mendes, additional, and Miranda, Angélica Espinosa, additional

Published
2023
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10. Acceptability of short message service (SMS) as a tool for malaria treatment adherence in the Brazilian Amazon: a qualitative study

Author

Rodovalho, Sheila, primary, Dias, Ádila Liliane Barros, additional, Ade, Maria Paz, additional, Saint-Gerons, Diego Macias, additional, Castro, Jose Luis, additional, Beratarrechea, Andrea, additional, Murta, Felipe Leão Gomes, additional, Santos, Alicia Cacau Patrine dos, additional, Marques, Leonardo Lincoln Gomes, additional, Sampaio, Vanderson Souza, additional, Baia-da-Silva, Djane Clarys, additional, and Monteiro, Wuelton Marcelo, additional

Published
2023
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11. Pregnancy outcomes after snakebite envenomations: A retrospective cohort in the Brazilian Amazonia

Author

Nascimento, Thaís P., primary, Vilhena Silva-Neto, Alexandre, additional, Baia-da-Silva, Djane Clarys, additional, da Silva Balieiro, Patrícia Carvalho, additional, Baleiro, Antônio Alcirley da Silva, additional, Sachett, Jacqueline, additional, Brasileiro, Lisele, additional, Sartim, Marco A., additional, Martinez-Espinosa, Flor Ernestina, additional, Wen, Fan Hui, additional, Pucca, Manuela B., additional, Gerardo, Charles J., additional, Sampaio, Vanderson S., additional, Ferreira de Aquino, Priscila, additional, and Monteiro, Wuelton M., additional

Published
2022
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12. Detection of Zika Virus in Aedes aegypti and Aedes albopictus Mosquitoes Collected in Urban Forest Fragments in the Brazilian Amazon.

Author

Gomes, Erika Oliveira, Sacchetto, Lívia, Teixeira, Maurício, Chaves, Bárbara Aparecida, Hendy, Adam, Mendonça, Claudia, Guimarães, Izabele, Linhares, Ramon, Brito, Daniela, Valério, Danielle, Cordeiro, Jady Shayenne Mota, Neto, Alexandre Vilhena Silva, Sampaio, Vanderson Souza, Scarpassa, Vera Margarete, Buenemann, Michaela, Vasilakis, Nikos, Baia-da-Silva, Djane Clarys, Nogueira, Maurício Lacerda, Mourão, Maria Paula Gomes, and Lacerda, Marcus Vinícius Guimarães

Subjects
AEDES aegypti, ZIKA virus, AEDES albopictus, MOSQUITOES, ZIKA virus infections, AEDES, CELL culture
Abstract

Zika virus (ZIKV) is an RNA flavivirus (Flaviviridae family) endemic in tropical and subtropical regions that is transmitted to humans by Aedes (Stegomyia) species mosquitoes. The two main urban vectors of ZIKV are Aedes aegypti and Aedes albopictus, which can be found throughout Brazil. This study investigated ZIKV infection in mosquito species sampled from urban forest fragments in Manaus (Brazilian Amazon). A total of 905 non-engorged female Ae. aegypti (22 specimens) and Ae. albopictus (883 specimens) were collected using BG-Sentinel traps, entomological hand nets, and Prokopack aspirators during the rainy and dry seasons between 2018 and 2021. All pools were macerated and used to inoculate C6/36 culture cells. Overall, 3/20 (15%) Ae. aegypti and 5/241 (2%) Ae. albopictus pools screened using RT-qPCR were positive for ZIKV. No supernatants from Ae. aegypti were positive for ZIKV (0%), and 15 out of 241 (6.2%) Ae. albopictus pools were positive. In this study, we provide the first-ever evidence of Ae. albopictus naturally infected with ZIKV in the Amazon region. [ABSTRACT FROM AUTHOR]

Published
2023
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13. The activity of methylene blue against asexual and sexual stages of Plasmodium vivax.

Author

Fabbri, Camila, Quaresma Ramos, Glenda, Baia-da-Silva, Djane Clarys, Oliveira Trindade, Alexandre, Salazar-Alvarez, Luis Carlos, Ferreira Neves, Juliana Costa, dos Santos Bastos, Ivanildes, Guimarães Costa, Allyson, Guimarães Lacerda, Marcus Vinicius, Marcelo Monteiro, Wuelton, Maranhão Costa, Fabio Trindade, and Costa Pinto Lopes, Stefanie

Subjects
PLASMODIUM vivax, MONONUCLEAR leukocytes, PLASMODIUM, METHYLENE blue
Abstract

Methylene blue (MB) is an alternative for combating drug-resistant malaria parasites. Its transmission-blocking potential has been demonstrated in vivo in murine models, in vitro, and in clinical trials. MB shows high efficacy against Plasmodium vivax asexual stages; however, its efficacy in sexual stages is unknown. In this study, we evaluated the potential of MB against asexual and sexual forms of P. vivax isolated from the blood of patients residing in the Brazilian Amazon. An ex vivo schizont maturation assay, zygote to ookinete transformation assay, direct membrane feed assay (DMFA), and standard membrane feed assay (SMFA) using P. vivax gametocytes with MB exposure were performed. A cytotoxicity assay was also performed on freshly collected peripheral blood mononuclear cells (PBMCs) and the hepatocyte carcinoma cell line HepG2. MB inhibited the P. vivax schizont maturation and demonstrated an IC50 lower than that of chloroquine (control drug). In the sexual forms, the MB demonstrated a high level of inhibition in the transformation of the zygotes into ookinetes. In the DMFA, MB did not considerably affect the infection rate and showed low inhibition, but it demonstrated a slight decrease in the infection intensity in all tested concentrations. In contrast, in the SMFA, MB was able to completely block the transmission at the highest concentration (20 μM). MB demonstrated low cytotoxicity to fresh PBMCs but demonstrated higher cytotoxicity to the hepatocyte carcinoma cell line HepG2. These results show that MB may be a potential drug for vivax malaria treatment. [ABSTRACT FROM AUTHOR]

Published
2023
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14. Case Report: Late-Onset Pneumonitis after Apoica pallida (Insecta: Hymenoptera) Sting with Anaphylactic Reaction in the Brazilian Amazon

Author

Pivoto João, Guilherme Augusto, primary, Bonates, Paula, additional, de Araújo, Thelma Silva, additional, Alencar, Aline, additional, da Silva Carvalho, Érica, additional, Baia-da-Silva, Djane Clarys, additional, de Almeida Gonçalves Sachett, Jacqueline, additional, and Monteiro, Wuelton Marcelo, additional

Published
2022
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15. Acceptability of the short message service (SMS) as a tool for malaria treatment adherence in the Brazilian Amazon: a qualitative study

Author

Rodovalho, Sheila Rodrigues, primary, Dias, Ádila Liliane Barros, additional, Ade, Maria Paz, additional, Saint-Gerons, Diego Macias, additional, Castro, Jose Luis, additional, Beratarrechea, Andrea, additional, Murta, Felipe Leão Gomes, additional, Santos, Alicia Patrine Cacau dos, additional, Marques, Leonardo Lincoln Gomes, additional, Sampaio, Vanderson Souza, additional, Baia-da-Silva, Djane Clarys, additional, and Monteiro, Wuelton Marcelo, additional

Published
2022
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16. The role of the peritrophic matrix and red blood cell concentration in Plasmodium vivax infection of Anopheles aquasalis

Author

Baia-da-Silva, Djane Clarys, Alvarez, Luis Carlos Salazar, Lizcano, Omaira Vera, Costa, Fabio Trindade Maranhão, Lopes, Stefanie Costa Pinto, Orfanó, Alessandra Silva, Pascoal, Denner Oliveira, Nacif-Pimenta, Rafael, Rodriguez, Iria Cabral, Guerra, Maria das Graças Vale Barbosa, Lacerda, Marcus Vinicius Guimarães, Secundino, Nagila Francinete Costa, Monteiro, Wuelton Marcelo, and Pimenta, Paulo Filemon Paolucci

Published
2018
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17. Prevalence and force of Plasmodium vivax blood-stage infection and associated clinical malaria burden in the Brazilian Amazon

Author

Monteiro, Wuelton, primary, Karl, Stephan, additional, Kuehn, Andrea, additional, Almeida, Anne, additional, White, Michael, additional, Vitor-Silva, Sheila, additional, Melo, Gisely, additional, Brito-Sousa, Jose Diego, additional, Baia-da-Silva, Djane Clarys, additional, Silva-Neto, Alexandre Vilhena, additional, Sampaio, Vanderson, additional, Bassat, Quique, additional, Felger, Ingrid, additional, Mueller, Ivo, additional, and Lacerda, Marcus, additional

Published
2022
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18. Descriptive study of intestinal parasites in a municipality of the western Brazilian Amazon

Author

Maciel, Marcel Gonçalves, primary, Lima, Walter dos Santos, additional, Baia da Silva, Djane Clarys, additional, Cezar, Rodolfo Silva Moreira, additional, Oliveira, Josue Costa, additional, Medeiros, Gessica Cristian Raposo, additional, Maciel, Marciane Gonçalves, additional, Guerra, Jorge Augusto de Oliveira, additional, and Guerra, Maria das Graças Vale Barbosa, additional

Published
2021
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19. Plasmodium vivax Gametocytes Adherence to Bone Marrow Endothelial Cells

Author

Salazar Alvarez, Luis Carlos, primary, Vera Lizcano, Omaira, additional, da Silva Barros, Dayanne Kamylla Alves, additional, Baia-da-Silva, Djane Clarys, additional, Monteiro, Wuelton Marcelo, additional, Pimenta, Paulo Filemon Paolluci, additional, de Lacerda, Marcus Vinicius Guimarães, additional, Costa, Fabio Trindade Maranhão, additional, and Lopes, Stefanie Costa Pinto, additional

Published
2021
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21. Prevalence of Glucose 6-Phosphate Dehydrogenase Deficiency in Highly Malaria-Endemic Municipalities in the Brazilian Amazon: A Regionwide Screening Study

Author

Nascimento, Joabi Rocha, primary, Brito-Sousa, Jose Diego, additional, Almeida, Anne Cristine Gomes, additional, de Melo, Marly Marques, additional, Costa, Monica Regina Farias, additional, Barbosa, Laila Rowena Albuquerque, additional, Ramos, Reinaldo Nery, additional, Silva-Neto, Alexandre Vilhena, additional, Balieiro, Patricia Carvalho da Silva, additional, Figueiredo, Erick Frota Gomes, additional, Silva, Emanuelle Lira, additional, Baia-da-Silva, Djane Clarys, additional, Bassat, Quique, additional, Sierra Romero, Gustavo Adolfo, additional, Melo, Gisely Cardoso, additional, Sampaio, Vanderson Souza, additional, Lacerda, Marcus, additional, and Monteiro, Wuelton, additional

Published
2021
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22. Correction for Ferreira et al., “Computational Chemogenomics Drug Repositioning Strategy Enables the Discovery of Epirubicin as a New Repurposed Hit for Plasmodium falciparum and P. vivax”

Author

Ferreira, Letícia Tiburcio, primary, Rodrigues, Juliana, additional, Cassiano, Gustavo Capatti, additional, Tavella, Tatyana Almeida, additional, Tomaz, Kaira Cristina Peralis, additional, Baia-da-Silva, Djane Clarys, additional, Souza, Macejane Ferreira, additional, Lima, Marilia Nunes do Nascimento, additional, Mottin, Melina, additional, Almeida, Ludimila Dias, additional, Calit, Juliana, additional, Puça, Maria Carolina Silva de Barros, additional, Melo, Gisely Cardoso, additional, Bargieri, Daniel Youssef, additional, Lopes, Stefanie Costa Pinto, additional, Lacerda, Marcus Vinicius Guimarães, additional, Bilsland, Elizabeth, additional, Sunnerhagen, Per, additional, Neves, Bruno Junior, additional, Andrade, Carolina Horta, additional, Cravo, Pedro Vitor Lemos, additional, and Costa, Fabio Trindade Maranhão, additional

Published
2020
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23. Computational Chemogenomics Drug Repositioning Strategy Enables the Discovery of Epirubicin as a New Repurposed Hit for Plasmodium falciparum and P. vivax

Author

Ferreira, Letícia Tiburcio, primary, Rodrigues, Juliana, additional, Cassiano, Gustavo Capatti, additional, Tavella, Tatyana Almeida, additional, Tomaz, Kaira Cristina Peralis, additional, Baia-da-Silva, Djane Clarys, additional, Souza, Macejane Ferreira, additional, Lima, Marilia Nunes do Nascimento, additional, Mottin, Melina, additional, Almeida, Ludimila Dias, additional, Calit, Juliana, additional, Puça, Maria Carolina Silva de Barros, additional, Melo, Gisely Cardoso, additional, Bargieri, Daniel Youssef, additional, Lopes, Stefanie Costa Pinto, additional, Lacerda, Marcus Vinicius Guimarães, additional, Bilsland, Elizabeth, additional, Sunnerhagen, Per, additional, Neves, Bruno Junior, additional, Andrade, Carolina Horta, additional, Cravo, Pedro Vitor Lemos, additional, and Costa, Fabio Trindade Maranhão, additional

Published
2020
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26. Löeffler’s syndrome

Author

Spener, Renata, primary, Safe, Izabella, additional, Baia-da-Silva, Djane Clarys, additional, de Lacerda, Marcus Vinicius Guimarães, additional, and Cordeiro-Santos, Marcelo, additional

Published
2019
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27. Clinical relevance of gallbladder wall thickening for dengue severity: A cross-sectional study

Author

Tavares, Michel de Araújo, primary, João, Guilherme Augusto Pivoto, additional, Bastos, Michele Souza, additional, Gimaque, João Bosco Lima, additional, Almeida, Anne Cristina Gomes, additional, Ngo, Thanh Thu, additional, Bahamon, Cecilia, additional, Baia-da-Silva, Djane Clarys, additional, Monteiro, Wuelton Marcelo, additional, Mourão, Maria Paula Gomes, additional, and Lacerda, Marcus Vinícius Guimarães, additional

Published
2019
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29. A simple, ex vivo phagocytosis assay of Plasmodium vivax merozoites by flow cytometry

Author

Farias, Elizangela, primary, Bezerra, Fhabiane, additional, Baia-da-Silva, Djane Clarys, additional, Chaves, Yury Oliveira, additional, Cardoza, Tatiana Bacry, additional, de Almeida, Maria Edilene Martins, additional, Oliveira, Lucas Barbosa, additional, Lalwani, Pritesh, additional, Orlandi, Patrícia Puccinelli, additional, Lacerda, Marcus Vinicius Guimaraes, additional, Lopes, Stefanie Costa Pinto, additional, and Nogueira, Paulo Afonso, additional

Published
2019
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30. Current vector control challenges in the fight against malaria in Brazil

Author

Baia-da-Silva, Djane Clarys, primary, Brito-Sousa, José Diego, additional, Rodovalho, Sheila Rodrigues, additional, Peterka, Cassio, additional, Moresco, Gilberto, additional, Lapouble, Oscar Martín Mesones, additional, Melo, Gisely Cardoso de, additional, Sampaio, Vanderson de Souza, additional, Alecrim, Maria das Graças Costa, additional, Pimenta, Paulo, additional, Lima, José Bento Pereira, additional, Lacerda, Marcus Vinícius Guimarães de, additional, and Monteiro, Wuelton Marcelo, additional

Published
2019
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31. Pharmacogenomics of thiopurines: distribution of TPMTand NUDT15polymorphisms in the Brazilian Amazon

Author

Ferreira, Guilherme Motta Antunes, Ribeiro Elias, Anna Beatriz, Nascimento, Joabi, Monteiro, Wuelton Marcelo, Melo, Gisely Cardoso, Baia-da-Silva, Djane Clarys, Lacerda, Marcus Vinícius Guimarães, and Suarez-Kurtz, Guilherme

Abstract

Supplemental Digital Content is available in the text.Reduced function alleles in the TPMTand NUDT15genes are risk factors for thiopurine toxicity. This study evaluated the influence of Native ancestry on the distribution of TPMT(rs1142345, rs1800460 and rs1800462) and NUDT15(rs116855232) polymorphisms and compound metabolic phenotypes in 128 healthy males from the Brazilian Amazon. The average proportion of Native and European ancestry differed greatly and significantly between self-declared Amerindians and non-Amerindians, although extensive admixture in both groups was evident. Native ancestry was not significantly associated with the frequency distribution of the TPMTor NUDT15polymorphisms investigated. The apparent discrepancy with our previous results for NUDT15rs116855232 in the Ad Mixed American superpopulation of the 1000 Genomes Project is ascribed to the diversity of the Native populations of the Americas. Based on the inferred TPMT/NUDT15 compound metabolic phenotypes, the Clinical Pharmacogenetics Implementation Consortium recommendations for starting thiopurine therapy with reduced doses or to consider dose reduction applied respectively to 3–5% and to 12–20% of the study cohorts.

Published
2020
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32. Correction for Ferreira et al., “Computational Chemogenomics Drug Repositioning Strategy Enables the Discovery of Epirubicin as a New Repurposed Hit for Plasmodium falciparumand P. vivax”

Author

Ferreira, Letícia Tiburcio, Rodrigues, Juliana, Cassiano, Gustavo Capatti, Tavella, Tatyana Almeida, Tomaz, Kaira Cristina Peralis, Baia-da-Silva, Djane Clarys, Souza, Macejane Ferreira, Lima, Marilia Nunes do Nascimento, Mottin, Melina, Almeida, Ludimila Dias, Calit, Juliana, Puça, Maria Carolina Silva de Barros, Melo, Gisely Cardoso, Bargieri, Daniel Youssef, Lopes, Stefanie Costa Pinto, Lacerda, Marcus Vinicius Guimarães, Bilsland, Elizabeth, Sunnerhagen, Per, Neves, Bruno Junior, Andrade, Carolina Horta, Cravo, Pedro Vitor Lemos, and Costa, Fabio Trindade Maranhão

Published
2020
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33. Computational Chemogenomics Drug Repositioning Strategy Enables the Discovery of Epirubicin as a New Repurposed Hit for Plasmodium falciparumand P. vivax

Author

Ferreira, Letícia Tiburcio, Rodrigues, Juliana, Cassiano, Gustavo Capatti, Tavella, Tatyana Almeida, Tomaz, Kaira Cristina Peralis, Baia-da-Silva, Djane Clarys, Souza, Macejane Ferreira, Lima, Marilia Nunes do Nascimento, Mottin, Melina, Almeida, Ludimila Dias, Calit, Juliana, Puça, Maria Carolina Silva de Barros, Melo, Gisely Cardoso, Bargieri, Daniel Youssef, Lopes, Stefanie Costa Pinto, Lacerda, Marcus Vinicius Guimarães, Bilsland, Elizabeth, Sunnerhagen, Per, Neves, Bruno Junior, Andrade, Carolina Horta, Cravo, Pedro Vitor Lemos, and Costa, Fabio Trindade Maranhão

Abstract

Widespread resistance against antimalarial drugs thwarts current efforts for controlling the disease and urges the discovery of new effective treatments. Drug repositioning is increasingly becoming an attractive strategy since it can reduce costs, risks, and time-to-market. Herein, we have used this strategy to identify novel antimalarial hits. We used a comparative in silicochemogenomics approach to select Plasmodium falciparumand Plasmodium vivaxproteins as potential drug targets and analyzed them using a computer-assisted drug repositioning pipeline to identify approved drugs with potential antimalarial activity.

Published
2020
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34. The role of the peritrophic matrix and red blood cell concentration in <italic>Plasmodium vivax</italic> infection of <italic>Anopheles aquasalis</italic>.

Author

Baia-da-Silva, Djane Clarys, Alvarez, Luis Carlos Salazar, Lizcano, Omaira Vera, Costa, Fabio Trindade Maranhão, Lopes, Stefanie Costa Pinto, Orfanó, Alessandra Silva, Pascoal, Denner Oliveira, Nacif-Pimenta, Rafael, Rodriguez, Iria Cabral, Guerra, Maria das Graças Vale Barbosa, Lacerda, Marcus Vinicius Guimarães, Secundino, Nagila Francinete Costa, Monteiro, Wuelton Marcelo, and Pimenta, Paulo Filemon Paolucci

Subjects
PERITROPHIC membranes, PLASMODIUM vivax, ERYTHROCYTES, ANOPHELES, PARASITIC diseases
Abstract

Background: Plasmodium vivax is predominant in the Amazon region, and enhanced knowledge of its development inside a natural vector, Anopheles aquasalis, is critical for future strategies aimed at blocking parasite development. The peritrophic matrix (PM), a chitinous layer produced by the mosquito midgut in response to blood ingestion, is a protective barrier against pathogens. Plasmodium can only complete its life-cycle, and consequently be transmitted to a new host, after successfully passing this barrier. Interestingly, fully engorged mosquitoes that had a complete blood meal form a thicker, well-developed PM than ones that feed in small amounts. The amount of red blood cells (RBC) in the blood meal directly influences the production of digestive enzymes and can protect parasites from being killed during the meal digestion. A specific study interrupting the development of the PM associated with the proteolytic activity inhibition, and distinct RBC concentrations, during the P. vivax infection of the New World malaria vector An. aquasalis is expected to clarify whether these factors affect the parasite development. Results: Absence of PM in the vector caused a significant reduction in P. vivax infection. However, the association of chitinase with trypsin inhibitor restored infection rates to those of mosquitoes with a structured PM. Also, only the ingestion of trypsin inhibitor by non-chitinase treated mosquitoes increased the infection intensity. Moreover, the RBC concentration in the infected P. vivax blood meal directly influenced the infection rate and its intensity. A straight correlation was observed between RBC concentrations and infection intensity. Conclusions: This study established that there is a balance between the PM role, RBC concentration and digestive enzyme activity influencing the establishment and development of P. vivax infection inside An. aquasalis. Our results indicate that the absence of PM in the midgut facilitates digestive enzyme dispersion throughout the blood meal, causing direct damage to P. vivax. On the other hand, high RBC concentrations support a better and thick, well-developed PM and protect P. vivax from being killed. Further studies of this complex system may provide insights into other details of the malaria vector response to P. vivax infection. [ABSTRACT FROM AUTHOR]

Published
2018
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35. COVID-19 in Brazil: advantages of a socialized unified health system and preparation to contain cases.

Author

Croda J, Oliveira WK, Frutuoso RL, Mandetta LH, Baia-da-Silva DC, Brito-Sousa JD, Monteiro WM, and Lacerda MVG

Subjects
Brazil epidemiology, COVID-19, Epidemiological Monitoring, Humans, Risk Assessment, SARS-CoV-2, Betacoronavirus, Coronavirus Infections epidemiology, Coronavirus Infections prevention & control, National Health Programs trends, Pandemics prevention & control, Pneumonia, Viral epidemiology, Pneumonia, Viral prevention & control, State Medicine trends
Abstract

The outbreak of new coronavirus disease 2019 (COVID-19) reported for the first time in Wuhan, China in late December 2019 have rapidly spread to other countries and it was declared on January 30, 2020 as a public health emergency of international concern (PHEIC) by the World Health Organization. Before the first COVID-19 cases were reported in Brazil, several measures have been implemented including the adjustment of legal framework to carry out isolation and quarantine. As the cases increased significantly, new measures, mainly to reduce mortality and severe cases, have also been implemented. Rapid and robust preparedness actions have been undertaken in Brazil while first cases have not yet been identified in Latin-American. The outcome of this early preparation should be analyzed in future studies.

Published
2020
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