18,587 results on '"Badawi, A."'
Search Results
2. Monitoring fairness in machine learning models that predict patient mortality in the ICU
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van Schaik, Tempest A., Liu, Xinggang, Atallah, Louis, and Badawi, Omar
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence - Abstract
This work proposes a fairness monitoring approach for machine learning models that predict patient mortality in the ICU. We investigate how well models perform for patient groups with different race, sex and medical diagnoses. We investigate Documentation bias in clinical measurement, showing how fairness analysis provides a more detailed and insightful comparison of model performance than traditional accuracy metrics alone., Comment: 8 pages
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- 2024
3. Investigating Privacy Attacks in the Gray-Box Setting to Enhance Collaborative Learning Schemes
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Mazzone, Federico, Badawi, Ahmad Al, Polyakov, Yuriy, Everts, Maarten, Hahn, Florian, and Peter, Andreas
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Computer Science - Cryptography and Security - Abstract
The notion that collaborative machine learning can ensure privacy by just withholding the raw data is widely acknowledged to be flawed. Over the past seven years, the literature has revealed several privacy attacks that enable adversaries to extract information about a model's training dataset by exploiting access to model parameters during or after training. In this work, we study privacy attacks in the gray-box setting, where the attacker has only limited access - in terms of view and actions - to the model. The findings of our investigation provide new insights for the development of privacy-preserving collaborative learning solutions. We deploy SmartCryptNN, a framework that tailors homomorphic encryption to protect the portions of the model posing higher privacy risks. Our solution offers a trade-off between privacy and efficiency, which varies based on the extent and selection of the model components we choose to protect. We explore it on dense neural networks, where through extensive evaluation of diverse datasets and architectures, we uncover instances where a favorable sweet spot in the trade-off can be achieved by safeguarding only a single layer of the network. In one of such instances, our approach trains ~4 times faster compared to fully encrypted solutions, while reducing membership leakage by 17.8 times compared to plaintext solutions., Comment: 19 pages, 7 figures, in submission
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- 2024
4. Geodesics structure and deflection angle of electrically charged black holes in gravity with a background Kalb-Ramond field
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al-Badawi, Ahmad, Shaymatov, Sanjar, and Sakallı, Izzet
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General Relativity and Quantum Cosmology - Abstract
This article investigates the geodesic structure and deflection angle of charged black holes in the presence of a nonzero vacuum expectation value background of the Kalb-Ramond field. Topics explored include null and timelike geodesics, energy extraction by collisions, and the motion of charged particles. The photon sphere radius is calculated and plotted to examine the effects of both the black hole charge ($Q$) and the Lorentz-violating parameter ($b$) on null geodesics. The effective potential for timelike geodesics is analyzed, and second-order analytical orbits are derived. We further show that the combined effects of Lorentz-violating parameter and electric charge can mimic a Kerr black hole spin parameter up to its maximum values, i.e., $a/M \sim 1$ thus suggesting that the current precision of measurements of highly spinning black hole candidates may not rule out the effect of Lorentz-violating parameter. The center of mass energy of colliding particles is also considered, demonstrating a decrease with increasing Lorentz-violating parameter. Circular orbiting particles of charged particles are discovered, with the minimum radius for a stable circular orbit decreasing as both $b$ and $Q$ increase. Results show that this circular orbit is particularly sensitive to changes in the Lorentz-violating parameter. Additionally, a timelike particle trajectory is demonstrated as a consequence of the combined effects of parameters $b$ and $Q$. Finally, the light deflection angle is analyzed using the weak field limit approach to determine the Lorentz-breaking effect, employing the Gauss-Bonnet theorem for computation. Findings are visualized with appropriate plots and thoroughly discussed.
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- 2024
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5. Neural Operator-Based Proxy for Reservoir Simulations Considering Varying Well Settings, Locations, and Permeability Fields
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Badawi, Daniel and Gildin, Eduardo
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Physics - Fluid Dynamics ,Computer Science - Machine Learning ,Physics - Geophysics - Abstract
Simulating Darcy flows in porous media is fundamental to understand the future flow behavior of fluids in hydrocarbon and carbon storage reservoirs. Geological models of reservoirs are often associated with high uncertainly leading to many numerical simulations for history matching and production optimization. Machine learning models trained with simulation data can provide a faster alternative to traditional simulators. In this paper we present a single Fourier Neural Operator (FNO) surrogate that outperforms traditional reservoir simulators by the ability to predict pressures and saturations on varying permeability fields, well locations, well controls, and number of wells. The maximum-mean relative error of 95\% of pressure and saturation predictions is less than 5\%. This is achieved by employing a simple yet very effective data augmentation technique that reduces the dataset size by 75\% and reduces overfitting. Also, constructing the input tensor in a binary fashion enables predictions on unseen well locations, well controls, and number of wells. Such model can accelerate history matching and reservoir characterization procedures by several orders of magnitude. The ability to predict on new well locations, well controls, and number of wells enables highly efficient reservoir management and optimization.
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- 2024
6. Topological AdS black holes surrounded by Chaplygin dark fluid: from stability to geometrothermodynamic analysis
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Sekhmani, Y., Luciano, G. G., Rayimbaev, J., Jasim, M. K., Al-Badawi, A., and Maurya, S. K.
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General Relativity and Quantum Cosmology ,High Energy Physics - Theory - Abstract
Implementing the concept of Dark Fluid with a Chaplygin-like equation of state within General Relativity, we construct a new higher-dimensional, static, and spherically symmetric anti-de Sitter (AdS) black hole solution. Energy conditions are explored alongside curvature singularity tools. The inspection at the level of the phase structure and $P-v$ critical behavior is carried out in the context of the extended phase space, where the cosmological constant appears as pressure. Our findings disclose non-trivial similarities between the small/large phase transition of AdS black holes surrounded by Chaplygin dark fluid and van der Waals systems' liquid/gas phase transition. This analysis offers insights into the physical interpretation of the $P-v$ diagram and identifies critical exponents that reveal the scaling behavior of thermodynamic quantities close to criticality in a universal manner. We finally deepen our understanding of the thermodynamic properties and microstructure of AdS black holes by leveraging the geometrothermodynamic formalism. Specifically, we employ tools, including Weinhold, Ruppeiner, Hendi-Panahiyan-Eslam-Momennia (HPEM) and Quevedo classes I and II. We show that each class of metrics predicts either the physical limitation point and/or the phase-transition critical points, with HPEM and Quevedo formulations providing richer information about the phase transitions. Altogether, this study contributes to advancing our knowledge of the role of Chaplygin gas in General Relativity and thoroughly examining the thermodynamic phase structure of high-dimensional AdS black holes under extreme conditions., Comment: 26 pages, 11 labeled figure, accepted for publication in Phys. Dark. Univ
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- 2024
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7. GUP corrected black holes with cloud of string
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Al-Badawi, Ahmad, Shaymatov, Sanjar, Jha, Sohan Kumar, and Rahaman, Anisur
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General Relativity and Quantum Cosmology - Abstract
We investigate shadows, deflection angle, quasinormal modes (QNMs), and sparsity of Hawking radiation of the Schwarzschild string cloud black hole's solution after applying quantum corrections required by the Generalised Uncertainty Principle (GUP). First, we explore the shadow's behaviour in the presence of a string cloud using three alternative GUP frameworks: linear quadratic GUP (LQGUP), quadratic GUP (QGUP), and linear GUP. We then used the weak field limit approach to determine the effect of the string cloud and GUP parameters on the light deflection angle, with computation based on the Gauss-Bonnet theorem. Next, to compute the quasinormal modes of Schwarzschild string clouds incorporating quantum correction with GUP, we determine the effective potentials generated by perturbing scalar, electromagnetic and fermionic fields, using the sixth-order WKB approach in conjunction with the appropriate numerical analysis. Our investigation indicates that string and linear GUP parameters have distinct and different effects on QNMs. We find that the greybody factor increases due to the presence of string cloud while the linear GUP parameter shows the opposite. We then examine the radiation spectrum and sparsity in the GUP corrected black hole with the cloud of string framework, which provides additional information about the thermal radiation released by black holes. Finally, our inquiries reveal that the influence of the string parameter and the quadratic GUP parameter on various astrophysical observables is comparable, however the impact of the linear GUP parameter is opposite., Comment: 32 pages, 7 tables, 14 captioned figures. Accepted for publication in Eur. Phys. J. C
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- 2024
8. Review of Zero-Shot and Few-Shot AI Algorithms in The Medical Domain
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Badawi, Maged, Abushanab, Mohammedyahia, Bhat, Sheethal, and Maier, Andreas
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Computer Science - Computer Vision and Pattern Recognition - Abstract
In this paper, different techniques of few-shot, zero-shot, and regular object detection have been investigated. The need for few-shot learning and zero-shot learning techniques is crucial and arises from the limitations and challenges in traditional machine learning, deep learning, and computer vision methods where they require large amounts of data, plus the poor generalization of those traditional methods. Those techniques can give us prominent results by using only a few training sets reducing the required amounts of data and improving the generalization. This survey will highlight the recent papers of the last three years that introduce the usage of few-shot learning and zero-shot learning techniques in addressing the challenges mentioned earlier. In this paper we reviewed the Zero-shot, few-shot and regular object detection methods and categorized them in an understandable manner. Based on the comparison made within each category. It been found that the approaches are quite impressive. This integrated review of diverse papers on few-shot, zero-shot, and regular object detection reveals a shared focus on advancing the field through novel frameworks and techniques. A noteworthy observation is the scarcity of detailed discussions regarding the difficulties encountered during the development phase. Contributions include the introduction of innovative models, such as ZSD-YOLO and GTNet, often showcasing improvements with various metrics such as mean average precision (mAP),Recall@100 (RE@100), the area under the receiver operating characteristic curve (AUROC) and precision. These findings underscore a collective move towards leveraging vision-language models for versatile applications, with potential areas for future research including a more thorough exploration of limitations and domain-specific adaptations.
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- 2024
9. Massless Dirac Perturbations of black holes in f(Q) gravity: quasinormal modes and weak deflection angle
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Al-Badawi, Ahmad and Jha, Sohan Kumar
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General Relativity and Quantum Cosmology - Abstract
This article considers a static and spherical black hole (BH) in f(Q) gravity. f(Q) gravity is the extension of symmetric teleparallel general relativity, where both curvature and torsion are vanishing, and gravity is described by nonmetricity. In this study, we investigate the possible implications of quasinormal modes (QNM) modified Hawking spectra, and deflection angles generated by the model. The WKB method is used to solve the equations of motion for massless Dirac perturbation fields and explore the impact of the nonmetricity parameter ($Q_{0}$). Based on the QNMs computation, we can ensure that the BH is stable against massless Dirac perturbations and as $Q_{0}$ increases the the oscillatory frequency of the mode decrease. We then discuss the weak deflection angle in the weak field limit approximation. We compute the deflection angle up to the fourth order of approximation and show how the nonmetricity parameter affects it. We find that the $Q_{0}$ parameter reduces the deflection angle.
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- 2024
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10. Total-Body Parametric Imaging Using Relative Patlak Plot
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Li, Siqi, Abdelhafez, Yasser G., Nardo, Lorenzo, Cherry, Simon R., Badawi, Ramsey D., and Wang, Guobao
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Physics - Medical Physics - Abstract
Standard Patlak plot is widely used to describe FDG kinetics for dynamic PET imaging. Whole-body Patlak parametric imaging remains constrained due to the need for a full-time input function. Here, we demonstrate the Relative Patlak (RP) plot, which eliminates the need for the early-time input function, for total-body parametric imaging and its application to clinical 20-min scan acquired in list-mode. We demonstrated that the RP intercept b' is equivalent to a ratio of standardized uptake value relative to the blood, while the RP slope Ki' is equal to the standard Patlak Ki multiplied by a global scaling factor for each subject. One challenge in applying RP to a short scan duration (20 min) is the high noise in parametric images. We applied a deep kernel method for noise reduction. Using the standard Patlak plot as the reference, the RP method was evaluated for lesion quantification, lesion-to-background contrast, and myocardial visualization in total-body parametric imaging with uEXPLORER in 22 human subjects who underwent a 1-h dynamic 18F-FDG scan. The RP method was also applied to the dynamic data regenerated from a clinical standard 20-min scan either at 1-h or 2-h post-injection for two cancer patients. We demonstrated that it is feasible to obtain high-quality parametric images from 20-min dynamic scans using the RP plot with a self-supervised deep-kernel noise reduction strategy. The RP Ki' highly correlated with Ki in lesions and major organs, demonstrating its quantitative potential across subjects. Compared to conventional SUVs, the Ki' images significantly improved lesion contrast and enabled visualization of the myocardium for potential cardiac assessment. The application of RP parametric imaging to two clinical scans also showed similar benefits. Total-body PET with the RP plot is feasible to generate parametric images from the dynamic data of a 20-min clinical scan.
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- 2024
11. The role of brown adipose tissue in branched-chain amino acid clearance in people
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Abdelhafez, Yasser G, Wang, Guobao, Li, Siqi, Pellegrinelli, Vanessa, Chaudhari, Abhijit J, Ramirez, Anthony, Sen, Fatma, Vidal-Puig, Antonio, Sidossis, Labros S, Klein, Samuel, Badawi, Ramsey D, and Chondronikola, Maria
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Biomedical and Clinical Sciences ,Clinical Sciences ,Nutrition ,Obesity ,Clinical Research ,Diabetes ,Cancer ,Metabolic and endocrine ,Human genetics ,Human metabolism - Abstract
Brown adipose tissue (BAT) in rodents appears to be an important tissue for the clearance of plasma branched-chain amino acids (BCAAs) contributing to improved metabolic health. However, the role of human BAT in plasma BCAA clearance is poorly understood. Here, we evaluate patients with prostate cancer who underwent positron emission tomography-computed tomography imaging after an injection of 18F-fluciclovine (L-leucine analog). Supraclavicular adipose tissue (AT; primary location of human BAT) has a higher net uptake rate for 18F-fluciclovine compared to subcutaneous abdominal and upper chest AT. Supraclavicular AT 18F-fluciclovine net uptake rate is lower in patients with obesity and type 2 diabetes. Finally, the expression of genes involved in BCAA catabolism is higher in the supraclavicular AT of healthy people with high BAT volume compared to those with low BAT volume. These findings support the notion that BAT can potentially function as a metabolic sink for plasma BCAA clearance in people.
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- 2024
12. Performance Characteristics of the NeuroEXPLORER, a Next-Generation Human Brain PET/CT Imager.
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Li, Hongdi, Badawi, Ramsey, Cherry, Simon, Fontaine, Kathryn, He, Liuchun, Henry, Shannan, Hillmer, Ansel, Hu, Lingzhi, Khattar, Nikkita, Leung, Edwin, Li, Tiantian, Li, Yusheng, Liu, Chi, Liu, Peng, Lu, Zhenrui, Majewski, Stanislaw, Matuskey, David, Morris, Evan, Mulnix, Tim, Omidvari, Negar, Samanta, Suranjana, Selfridge, Aaron, Sun, Xishan, Toyonaga, Takuya, Volpi, Tommaso, Zeng, Tianyi, Jones, Terry, Qi, Jinyi, and Carson, Richard
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DOI ,NEMA ,NeuroEXPLORER ,brain PET ,high resolution - Abstract
The collaboration of Yale, the University of California, Davis, and United Imaging Healthcare has successfully developed the NeuroEXPLORER, a dedicated human brain PET imager with high spatial resolution, high sensitivity, and a built-in 3-dimensional camera for markerless continuous motion tracking. It has high depth-of-interaction and time-of-flight resolutions, along with a 52.4-cm transverse field of view (FOV) and an extended axial FOV (49.5 cm) to enhance sensitivity. Here, we present the physical characterization, performance evaluation, and first human images of the NeuroEXPLORER. Methods: Measurements of spatial resolution, sensitivity, count rate performance, energy and timing resolution, and image quality were performed adhering to the National Electrical Manufacturers Association (NEMA) NU 2-2018 standard. The systems performance was demonstrated through imaging studies of the Hoffman 3-dimensional brain phantom and the mini-Derenzo phantom. Initial 18F-FDG images from a healthy volunteer are presented. Results: With filtered backprojection reconstruction, the radial and tangential spatial resolutions (full width at half maximum) averaged 1.64, 2.06, and 2.51 mm, with axial resolutions of 2.73, 2.89, and 2.93 mm for radial offsets of 1, 10, and 20 cm, respectively. The average time-of-flight resolution was 236 ps, and the energy resolution was 10.5%. NEMA sensitivities were 46.0 and 47.6 kcps/MBq at the center and 10-cm offset, respectively. A sensitivity of 11.8% was achieved at the FOV center. The peak noise-equivalent count rate was 1.31 Mcps at 58.0 kBq/mL, and the scatter fraction at 5.3 kBq/mL was 36.5%. The maximum count rate error at the peak noise-equivalent count rate was less than 5%. At 3 iterations, the NEMA image-quality contrast recovery coefficients varied from 74.5% (10-mm sphere) to 92.6% (37-mm sphere), and background variability ranged from 3.1% to 1.4% at a contrast of 4.0:1. An example human brain 18F-FDG image exhibited very high resolution, capturing intricate details in the cortex and subcortical structures. Conclusion: The NeuroEXPLORER offers high sensitivity and high spatial resolution. With its long axial length, it also enables high-quality spinal cord imaging and image-derived input functions from the carotid arteries. These performance enhancements will substantially broaden the range of human brain PET paradigms, protocols, and thereby clinical research applications.
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- 2024
13. Optimization-derived blood input function using a kernel method and its evaluation with total-body PET for brain parametric imaging
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Zhu, Yansong, Tran, Quyen, Wang, Yiran, Badawi, Ramsey D, Cherry, Simon R, Qi, Jinyi, Abbaszadeh, Shiva, and Wang, Guobao
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Biomedical and Clinical Sciences ,Health Sciences ,Clinical Research ,Biomedical Imaging ,Brain Disorders ,Bioengineering ,Humans ,Positron-Emission Tomography ,Brain ,Whole Body Imaging ,Image Processing ,Computer-Assisted ,Algorithms ,Tracer kinetic modeling ,Input function estimation ,Kernel method ,Total-body PET ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Neurology & Neurosurgery ,Biomedical and clinical sciences ,Health sciences - Abstract
Dynamic PET allows quantification of physiological parameters through tracer kinetic modeling. For dynamic imaging of brain or head and neck cancer on conventional PET scanners with a short axial field of view, the image-derived input function (ID-IF) from intracranial blood vessels such as the carotid artery (CA) suffers from severe partial volume effects. Alternatively, optimization-derived input function (OD-IF) by the simultaneous estimation (SIME) method does not rely on an ID-IF but derives the input function directly from the data. However, the optimization problem is often highly ill-posed. We proposed a new method that combines the ideas of OD-IF and ID-IF together through a kernel framework. While evaluation of such a method is challenging in human subjects, we used the uEXPLORER total-body PET system that covers major blood pools to provide a reference for validation.MethodsThe conventional SIME approach estimates an input function using a joint estimation together with kinetic parameters by fitting time activity curves from multiple regions of interests (ROIs). The input function is commonly parameterized with a highly nonlinear model which is difficult to estimate. The proposed kernel SIME method exploits the CA ID-IF as a priori information via a kernel representation to stabilize the SIME approach. The unknown parameters are linear and thus easier to estimate. The proposed method was evaluated using 18F-fluorodeoxyglucose studies with both computer simulations and 20 human-subject scans acquired on the uEXPLORER scanner. The effect of the number of ROIs on kernel SIME was also explored.ResultsThe estimated OD-IF by kernel SIME showed a good match with the reference input function and provided more accurate estimation of kinetic parameters for both simulation and human-subject data. The kernel SIME led to the highest correlation coefficient (R = 0.97) and the lowest mean absolute error (MAE = 10.5 %) compared to using the CA ID-IF (R = 0.86, MAE = 108.2 %) and conventional SIME (R = 0.57, MAE = 78.7 %) in the human-subject evaluation. Adding more ROIs improved the overall performance of the kernel SIME method.ConclusionThe proposed kernel SIME method shows promise to provide an accurate estimation of the blood input function and kinetic parameters for brain PET parametric imaging.
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- 2024
14. Quazinormal modes and greybody factor of black hole surrounded by a quintessence in the S-V-T modified gravity as well as shadow
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Al-Badawi, Ahmad
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General Relativity and Quantum Cosmology - Abstract
The purpose of this study is to investigate the quasinormal modes (QNMs), greybody factors (GFs) and shadows in a plasma of a black hole (BH) surrounded by an exotic fluid of quintessence type in a scalar-vector-tensor modified gravity. The effects of a quintessence scalar field and the modified gravity (MOG) field on the QNM, GF, and shadow are examined. Using the sixth-order WKB approach, we investigate the QNMs of massless scalar and electromagnetic perturbations. Our findings show that as the quintessence and the MOG parameter ($\epsilon$ and $\alpha$) increase, the oscillation frequencies decrease significantly. Gravitational wave damping, on the other hand, decreases with increasing $\epsilon$ and $\alpha$. In addition, we obtain an analytical solution for the transmission coefficients (GF) and demonstrate that more thermal radiation reaches the observer at spatial infinity as both the $\epsilon$ and $\alpha$ parameters increase. We also investigate the effect of the plasma background on the BH shadow and show that as the plasma background parameter increases, the shadow radius slightly shrinks. Nevertheless, the shadow radius increases as $\alpha$ and $\epsilon$ increase. Particularly intriguing is the fact that increasing $\epsilon$ has a greater impact on the shadow radius than increasing $\alpha$, indicating that the quintessence parameter has a greater impact than the MOG parameter.
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- 2024
15. Dose-aware Diffusion Model for 3D Low-dose PET: Multi-institutional Validation with Reader Study and Real Low-dose Data
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Xie, Huidong, Gan, Weijie, Zhou, Bo, Chen, Ming-Kai, Kulon, Michal, Boustani, Annemarie, Spencer, Benjamin A., Bayerlein, Reimund, Ji, Wei, Chen, Xiongchao, Liu, Qiong, Guo, Xueqi, Xia, Menghua, Zhou, Yinchi, Liu, Hui, Guo, Liang, An, Hongyu, Kamilov, Ulugbek S., Wang, Hanzhong, Li, Biao, Rominger, Axel, Shi, Kuangyu, Wang, Ge, Badawi, Ramsey D., and Liu, Chi
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Electrical Engineering and Systems Science - Image and Video Processing - Abstract
Reducing scan times, radiation dose, and enhancing image quality, especially for lower-performance scanners, are critical in low-count/low-dose PET imaging. Deep learning (DL) techniques have been investigated for PET image denoising. However, existing models have often resulted in compromised image quality when achieving low-dose PET and have limited generalizability to different image noise-levels, acquisition protocols, and patient populations. Recently, diffusion models have emerged as the new state-of-the-art generative model to generate high-quality samples and have demonstrated strong potential for medical imaging tasks. However, for low-dose PET imaging, existing diffusion models failed to generate consistent 3D reconstructions, unable to generalize across varying noise-levels, often produced visually-appealing but distorted image details, and produced images with biased tracer uptake. Here, we develop DDPET-3D, a dose-aware diffusion model for 3D low-dose PET imaging to address these challenges. Collected from 4 medical centers globally with different scanners and clinical protocols, we extensively evaluated the proposed model using a total of 9,783 18F-FDG studies (1,596 patients) with low-dose/low-count levels ranging from 1% to 50%. With a cross-center, cross-scanner validation, the proposed DDPET-3D demonstrated its potential to generalize to different low-dose levels, different scanners, and different clinical protocols. As confirmed with reader studies performed by nuclear medicine physicians, experienced readers judged the images to be similar to or superior to the full-dose images and previous DL baselines based on qualitative visual impression. The presented results show the potential of achieving low-dose PET while maintaining image quality. Lastly, a group of real low-dose scans was also included for evaluation to demonstrate the clinical potential of DDPET-3D., Comment: 15 Pages, 15 Figures, 5 Tables. Paper under review. First-place Freek J. Beekman Young Investigator Award at SNMMI 2024. arXiv admin note: substantial text overlap with arXiv:2311.04248
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- 2024
16. Exposure-response relationships of venetoclax in combination with carfilzomib and dexamethasone in relapsed/refractory t(11;14) multiple myeloma patients
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Badawi, Mohamed Ali, Engelhardt, Benjamin, Dobkowska, Edyta, Deng, Rong, Kaufman, Jonathan L., Menon, Rajeev, and Salem, Ahmed Hamed
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- 2024
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17. Mathematical modeling of an isothermal tubular bioreactor coupled with batch culture for ethanol production: a one-dimensional approach
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Al Arni, Saleh, Converti, Attilio, Elwaheidi, Mahmoud, Elmadssia, Sami, and Badawi, Sufian A.
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- 2024
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18. The Impact of PhD Degrees in Academic Plastic Surgery: An In-depth Analysis of Faculty and Residents
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Elmorsi, Rami, Asaad, Malke, Vyas, Krishna, Badawi, Omar, Clemen, Mark W., Chu, Carrie K., and Selber, Jesse
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- 2024
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19. Optimizing the coagulation/flocculation process for the treatment of slaughterhouse and meat processing wastewater: experimental studies and pilot-scale proposal
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Badawi, A. K., Hassan, R., Farouk, M., Bakhoum, E. S., and Salama, R. S.
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- 2024
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20. HAEPF: hybrid approach for estimating pitch frequency in the presence of reverberation
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Hassan, Emad S., Neyazi, Badawi, Seddeq, H. S., Mahmoud, Adel Zaghloul, Oshaba, Ahmed S., El-Emary, Atef, and Abd El‑Samie, Fathi E.
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- 2024
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21. An innovative biosensor harnessing the potential of photonic crystal technology to identify a multitude of cancer cells, distinguished by heightened quality factor and sensitivity
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Badawi, Kareem A., Hamed, Mahmoud M., and Mohammed, Nazmi A.
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- 2024
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22. The First Reported Foodborne Botulism Outbreak in Riyadh, Saudi Arabia: Lessons Learned
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Gul Dar, Nadeem, Alfaraj, Sarah H., Alboqmy, Khulood Naser, Khanum, Nazia, Alshakrah, Faleh, Abdallah, Hassan, Badawi, Mohammad Hosni, Alharbi, Ohoud Mohammed, Alshiekh, Khadijh Ahmed, Alsallum, Abdullah M, Shrahili, Ahmed Hassan, Zeidan, Zeidan A, Abdallah, Zaki, Majrashi, Ahmed Ali, and Memish, Ziad A.
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- 2024
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23. Square-difference factor absorbing ideals of a commutative ring
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Anderson, David F., Badawi, Ayman, and Coykendall, Jim
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Mathematics - Commutative Algebra ,13A15, 13F05, 13G05 - Abstract
Let $R$ be a commutative ring with $1 \neq 0$. A proper ideal $I$ of $R$ is a {\it square-difference factor absorbing ideal} (sdf-absorbing ideal) of $R$ if whenever $a^2 - b^2 \in I$ for $0 \neq a, b \in R$, then $a + b \in I$ or $a - b \in I$. In this paper, we introduce and investigate sdf-absorbing ideals., Comment: 18 pages
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- 2024
24. Hairy black hole, Fermionic greybody factors, Quasinormal modes, Hawking radiation, Power spectrum and sparsity
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Al-Badawi, Ahmad, Jha, Sohan Kumar, and Rahaman, Anisur
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General Relativity and Quantum Cosmology - Abstract
A hairy black hole (HBH) emerges due to matter surrounding the Schwarzschild metric when using the Extended Gravitational Decoupling (GD) approach. The fermionic greybody factors (GFs) and quasinormal modes (QNMs) as well as Hawking spectra and sparsity of HBH solutions are investigated. We consider massive and massless spin- 1/2 fermions, along with massless spin- 3/2 fermions. The equations of the effective potential for fermions with different spins are derived in HBH spacetime. Then, the rigorous bound method is used to calculate the fermionic spin- 1/2 and spin- 3/2 GFs. With the time domain integration method at our disposal, we illustrate the impact of additional parameters on the ringdown waveform of the massless fermionic spin -1/2 and spin -3/2 fields and, in turn, on their quasinormal modes. We then delve into investigating the Hawking spectra and sparsity of the radiation emitted by an HBH. Hairy parameters significantly affect the sparsity of Hawking radiation as well. We observe that the total power emitted by the BH increases both with $\alpha$ and $Q$ but decreases with $l_{0}$. Our study conclusively shows the significant impact of the additional parameters on important astrophysical phenomena such as quasinormal modes, Hawking spectra, and sparsity.
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- 2024
25. Feasibility of PET-enabled dual-energy CT imaging: First physical phantom and patient results
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Zhu, Yansong, Li, Siqi, Xie, Zhaoheng, Leung, Edwin K., Bayerlein, Reimund, Omidvari, Negar, Cherry, Simon R., Qi, Jinyi, Badawi, Ramsey D., Spencer, Benjamin A., and Wang, Guobao
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Physics - Medical Physics - Abstract
X-ray computed tomography (CT) in PET/CT is commonly operated with a single energy, resulting in a limitation of lacking tissue composition information. Dual-energy (DE) spectral CT enables material decomposition by using two different x-ray energies and may be combined with PET for improved multimodality imaging, but would either require hardware upgrade or increase radiation dose due to the added second x-ray CT scan. Recently proposed PET-enabled DECT method allows dual-energy spectral imaging using a conventional PET/CT scanner without the need for a second x-ray CT scan. A gamma-ray CT (gCT) image at 511 keV can be generated from the existing time-of-flight PET data with the maximum-likelihood attenuation and activity (MLAA) approach and is then combined with the low-energy x-ray CT image to form dual-energy spectral imaging. To improve the image quality of gCT, a kernel MLAA method was further proposed by incorporating x-ray CT as a priori information. The concept of this PET-enabled DECT has been validated using simulation studies, but not yet with 3D real data. In this work, we developed a general open-source implementation for gCT reconstruction from PET data and use this implementation for the first real data validation with both a physical phantom study and a human subject study on a uEXPLORER total-body PET/CT system. These results have demonstrated the feasibility of this method for spectral imaging and material decomposition., Comment: 8 pages, 11 figures
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- 2024
26. Particle dynamics and shadow of a regular non-minimal magnetic black hole
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Al-Badawi, Ahmad and Owaidat, M. Q.
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General Relativity and Quantum Cosmology - Abstract
In this paper, we study the dynamics of a test particle around a regular black hole (BH) in a non-minimal Einstein Yang Mills (EYM) theory and examine the BH shadow. The EYM theory is a non-minimally coupled theory in which curvature couples to non-Abelian gauge fields. We investigate particle motion with parameters in EYM BH for massless and massive particles. This work provides the horizon structure, photon radius and inner stable circular orbit (ISCO) of a mass particle with EYM BH parameters. An analysis is provided of the effective potential as well as the possible orbits for test particles under various EYM BH parameters values. In timelike radial geodesics, we find that for smaller values of magnetic charge, particles following a timelike radial geodesic are hastier in EYM BH, and hence arrive at the center faster than those traveling a Schwarzschild BH geodesic. However, at larger values of the magnetic charge, the inverse effect is observed. The effect of model parameters is investigated in order to study the ISCO, photon radius, orbit stability (Lyapunov exponent), and effective force on particles for the BH in the EYM theory. Finally, we investigate the BH shadow. We find that higher magnetic charge values and non-minimal coupling parameters result in smaller shadow radius values.
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- 2024
27. Accretion, greybody factor, quasinormal modes, power spectrum, sparsity of Hawking radiation, and weak gravitational lensing of a minimum measurable length inspired Schwarzchild black hole
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Barman, Himangshu, Al-Badawi, Ahmad, Jha, Sohan Kumar, and Rahaman, Anisur
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General Relativity and Quantum Cosmology - Abstract
In this manuscript, we delve into an analytic and numerical probe of shadow with different accretion models, quasinormal modes, Hawking radiation, and gravitational lensing to study observational impacts of quantum effect introduced throughh linear-quadratic GUP(LQG). Our investigation reveals that the shadows of LQG modified black holes are smaller and brighter than Schwarzschild black holes. To examine the impact of the quantum correction on the quasinormal mode, linear-quadratic GUP modified black holes are explored under scalar and electromagnetic field perturbation. Here, linear-quadratic GUP is used to capture quantum corrections. It is observed that the incorporation of quantum correction by linear-quadratic GUP alters the singularity structure of the black hole. To compute the quasinormal modes of this linear-quadratic GUP-inspired quantum-corrected black holes, we compute the effective potential generated under the perturbation of scalar and electromagnetic field, and then we use the sixth-order WKB approach in conjunction with the appropriate numerical analysis. We find that the greybody factor decreases with the GUP parameter $\alpha$ implying that the probability of transmission decreases with the GUP parameter. The total power emitted by LQG modified black hole is found to be greater than that emitted by Schwarzschild black hole. Finally, we study weak gravitational lensing and make a comparison with quadratic GUP and linear GUP modified black holes.
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- 2024
28. A regular MOG black hole's impact on shadows and gravitational weak lensing in the presence of quintessence field
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Al-Badawi, Ahmad, Shaymatov, Sanjar, Alloqulov, Mirzabek, and Wang, Anzhong
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General Relativity and Quantum Cosmology - Abstract
We investigate the impact of the modified gravity (MOG) field and the quintessence scalar field on horizon evolution, black hole (BH) shadow and the weak gravitational lensing around a static spherically symmetric BH. We first begin to write the BH metric associated with the MOG parameter and quintessence scalar field. We then determine the BH shadow and obtain numerical solutions for the photon sphere and shadow radius. We show that the MOG ($\alpha$) and the quintessence ($c$) parameters have a significant impact on BH shadow and photon sphere. Based on the analysis, we further show that the combined effects of the MOG parameter and quintessential field can increase the values of BH shadow and photon sphere radii. We also obtain constraints on the BH parameters by applying the observational data of Sgr A$^{\star}$ and M87$^{\star}$. Finally, we consider the weak deflection angle of BH within the context of the Gauss-Bonnet theorem (GBT) and show that the combined effects of the MOG and quintessence parameters do make the value of the deflection angle grow, referring to remarkable property being in well agreement with the physical meaning of both parameters that can maintain the strong gravitational field in the surrounding environment of BH., Comment: 14 pages, 2 tables, 9 captioned figures
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- 2024
29. Shadows and weak gravitational lensing by the black hole in Einstein-Maxwell-scalar theory
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Al-Badawi, Ahmad, Alloqulov, Mirzabek, Shaymatov, Sanjar, and Ahmedov, Bobomurat
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General Relativity and Quantum Cosmology - Abstract
In this paper, we investigate the optical properties of a charged black hole in Einstein-Maxwell-scalar (EMS) theory. We evaluate the shadow cast by the black hole and obtain analytical solutions for both the radius of the photon sphere and the shadow radius. We observe that the black hole parameters $\gamma$ and $\beta$ both influence the shadow of black hole. It is shown that the photon sphere and the shadow radius increase as a consequence of the presence of parameter $\gamma$. Interestingly, we show that shadow radius decreases first and then remains unchanged due to the impact of parameter $\beta$. Finally, we consider the weak gravitational lensing and the total magnification of lensed images around black hole. We find that the black hole charge and parameter $\beta$ both give rise to a significant effect, reducing the deflection angle. Similarly, the same behavior for the total magnification is observed due to the effect of black hole charge and parameter $\beta$., Comment: 9 pages, one table, 9 captioned figures, Accepted for publication in Chinese Physics C
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- 2024
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30. High-Temporal-Resolution Kinetic Modeling of Lung Tumors with Dual-Blood Input Function Using Total-Body Dynamic PET.
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Wang, Yiran, Abdelhafez, Yasser, Spencer, Benjamin, Verma, Rashmi, Parikh, Mamta, Stollenwerk, Nicholas, Nardo, Lorenzo, Jones, Terry, Badawi, Ramsey, Cherry, Simon, and Wang, Guobao
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dual-blood input function ,high temporal resolution ,kinetic modeling ,lung cancer ,total-body dynamic PET ,Humans ,Lung Neoplasms ,Male ,Female ,Middle Aged ,Kinetics ,Positron-Emission Tomography ,Models ,Biological ,Adult ,Fluorodeoxyglucose F18 ,Aged ,Whole Body Imaging ,Positron Emission Tomography Computed Tomography ,Image Processing ,Computer-Assisted ,Time Factors ,Radiopharmaceuticals - Abstract
The lungs are supplied by both the pulmonary arteries carrying deoxygenated blood originating from the right ventricle and the bronchial arteries carrying oxygenated blood downstream from the left ventricle. However, this effect of dual blood supply has never been investigated using PET, partially because the temporal resolution of conventional dynamic PET scans is limited. The advent of PET scanners with a long axial field of view, such as the uEXPLORER total-body PET/CT system, permits dynamic imaging with high temporal resolution (HTR). In this work, we modeled the dual-blood input function (DBIF) and studied its impact on the kinetic quantification of normal lung tissue and lung tumors using HTR dynamic PET imaging. Methods: Thirteen healthy subjects and 6 cancer subjects with lung tumors underwent a dynamic 18F-FDG scan with the uEXPLORER for 1 h. Data were reconstructed into dynamic frames of 1 s in the early phase. Regional time-activity curves of lung tissue and tumors were analyzed using a 2-tissue compartmental model with 3 different input functions: the right ventricle input function, left ventricle input function, and proposed DBIF, all with time delay and dispersion corrections. These models were compared for time-activity curve fitting quality using the corrected Akaike information criterion and for differentiating lung tumors from lung tissue using the Mann-Whitney U test. Voxelwise multiparametric images by the DBIF model were further generated to verify the regional kinetic analysis. Results: The effect of dual blood supply was pronounced in the high-temporal-resolution time-activity curves of lung tumors. The DBIF model achieved better time-activity curve fitting than the other 2 single-input models according to the corrected Akaike information criterion. The estimated fraction of left ventricle input was low in normal lung tissue of healthy subjects but much higher in lung tumors (∼0.04 vs. ∼0.3, P < 0.0003). The DBIF model also showed better robustness in the difference in 18F-FDG net influx rate [Formula: see text] and delivery rate [Formula: see text] between lung tumors and normal lung tissue. Multiparametric imaging with the DBIF model further confirmed the differences in tracer kinetics between normal lung tissue and lung tumors. Conclusion: The effect of dual blood supply in the lungs was demonstrated using HTR dynamic imaging and compartmental modeling with the proposed DBIF model. The effect was small in lung tissue but nonnegligible in lung tumors. HTR dynamic imaging with total-body PET can offer a sensitive tool for investigating lung diseases.
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- 2024
31. Supplemental Transmission Aided Attenuation Correction for Quantitative Cardiac PET.
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Park, Mi-Ae, Zaha, Vlad, Bowen, Spencer, and Badawi, Ramsey
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Humans ,Positron Emission Tomography Computed Tomography ,Multimodal Imaging ,Magnetic Resonance Imaging ,Positron-Emission Tomography ,Algorithms ,Image Processing ,Computer-Assisted - Abstract
Quantitative PET attenuation correction (AC) for cardiac PET/CT and PET/MR is a challenging problem. We propose and evaluate an AC approach that uses coincidences from a relatively weak and physically fixed sparse external source, in combination with that from the patient, to reconstruct μ -maps based on physics principles alone. The low 30 cm3 volume of the source makes it easy to fill and place, and the method does not use prior image data or attenuation map assumptions. Our supplemental transmission aided maximum likelihood reconstruction of attenuation and activity (sTX-MLAA) algorithm contains an attenuation map update that maximizes the likelihood of terms representing coincidences originating from tracer in the patient and a weighted expression of counts segmented from the external source alone. Both external source and patient scatter and randoms are fully corrected. We evaluated performance of sTX-MLAA compared to reference standard CT-based AC with FDG PET/CT phantom studies; including modeling a patient with myocardial inflammation. Through an ROI analysis we measured ≤ 5 % bias in activity concentrations for PET images generated with sTX-MLAA and a TX source strength ≥ 12.7 MBq, relative to CT-AC. PET background variability (from noise and sparse sampling) was substantially reduced with sTX-MLAA compared to using counts segmented from the transmission source alone for AC. Results suggest that sTX-MLAA will enable quantitative PET during cardiac PET/CT and PET/MR of human patients.
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- 2024
32. Advancing ZMF-spinel ferrites with Gd3+ doping: structural, magneto-optical enhancements, and superior gamma-ray shielding for high-tech applications
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Khalil, Huda F., Issa, Shams A. M., Elsharkawy, Sherif G., Boudaghi Malidarreh, Roya, Gad, Sara, Badawi, Ali, Fakhry, Fatma, and Zakaly, Hesham M. H.
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- 2024
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33. Digital Transformation of Human Resources: Implications, Practices, and Challenges
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Alshaibani, Mariam Khalid, Badawi, Sherien Sherif, Aoun, Malak, Kacprzyk, Janusz, Series Editor, and Hamdan, Allam, editor
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- 2025
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34. Digitalization in Human Resource Management in Bahrain: Employee Perspectives
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Alshaibani, Mariam Khalid, Badawi, Sherien Sherif, Aoun, Malak, Kacprzyk, Janusz, Series Editor, and Hamdan, Allam, editor
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- 2025
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35. Turkiye-Alliance of Sahel States Relations: A Preliminary Appraisal
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Mustapha, Ahmed Badawi
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Political science ,Economic Community of West African States - Abstract
This article documents a preliminary appraisal of Turkiye's relations with the newly formed Alliance of the Sahel States (AES), within the confines of security engagements, economic entanglements, and humanitarian/cultural interactions. To achieve this, the study investigates how the Heartland Theory and the smart power paradigm could assist in exploring Turkiye's relations with the Alliance. Analyzing official documents and secondary data, the paper takes the view that defense and security engagements have taken center stage of the relations, relegating economic and humanitarian issues to the periphery. This shift positions Turkiye to play a very influential role in Sahelian affairs, particularly in their defense and security. Considering the stiff competition from key non-Western countries with vested interest in the region, especially China and Russia, Turkiye must carefully navigate its relations with regional bodies like the Economic Community of West African States (ECOWAS) and these other external actors to promote regional stability and cooperation. Amidst the growing discontent expressed by the Alliance towards the Western countries, Ankara is compelled to exert its influential role in a manner different from its predecessors. Keywords: Turkiye, Alliance of Sahel States, Economy, Humanitarian Engagement, Security, West Africa, Introduction The Alliance of Sahel States (AES), comprising Mali, Burkina Faso, and Niger, is a coalition of neighboring Sahelian nations that have recently experienced coup d'etats and have decided to [...]
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- 2024
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36. Integration of Blended Learning and Project-Based Learning (BPjBL) on Achievement of Students' Learning Goals: A Meta-Analysis Study
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Badawi, Sumarno, Julham Hukom, Agung Prihatmojo, Abdul Manaf, Indah Suciati, and Asria Ratau
- Abstract
Many studies have identified differences in the effectiveness of the integration of blended learning and project-based learning (BPjBL) models on student achievement. However, the results of previous studies showed different results. Therefore, this study aims to determine the differences in the effectiveness of the integration of blended learning and project-based learning (BPjBL) models on student achievement, compared to traditional learning. The design used in this study was a contrast group meta-analysis. The studies analyzed to calculate the effect size were 11 primary studies that met the established inclusion criteria. To be more accurate, data analysis was performed with the help of JASP software version 0.16.3. The results of the analysis using the random effects approach obtained an overall effect size (d = 1.28; p <0.05). This effect size is included in the large effect category. It can be concluded that the use of the BPjBL model has a major effect on student achievement when compared to traditional learning. The meta-analysis in this study has no problem with publication bias, so this meta-analytic research is objective and scientifically justifiable. The results of this meta-analysis research show more accurate information, which can be used as a basis for policymaking, so as to improve the quality of learning.
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- 2023
37. Exploring the potential of metal-catalysis with N, N-type ligands in [3+2] cycloaddition reactions of azides and alkynes using theoretical tools
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Khairbek, Ali A., Al-Zaben, Maha I., Abbas, Faheem, Badawi, Mohammad Abd Al-Hakim, and Thomas, Renjith
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- 2024
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38. Risk Factors for Cerebral Vasospasm After Subarachnoid Hemorrhage: A Systematic Review of Observational Studies
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Tawakul, Abdullah, Alluqmani, Majed Mohammedali, Badawi, Ahmad Salim, Alawfi, Abdulaziz Khalid, Alharbi, Eyad Khalil, Aljohani, Sultan Abdulaziz, Mogharbel, Ghazi Haitham, Alahmadi, Hussam Abduljabbar, and Khawaji, Zakaria Yahya
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- 2024
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39. A Comprehensive Study of the Linear/Nonlinear Optical and Electrical Features of rGO/Co: TiO2 Nanostructures Incorporated PVP/PVA Blend
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Badawi, Ali and Alharthi, Sami S.
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- 2024
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40. Oxidation–reduction imaging of myoglobin reveals two-phase oxidation in the reperfused myocardium
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Badawi, Sally, Leboullenger, Clémence, Chourrout, Matthieu, Gouriou, Yves, Paccalet, Alexandre, Pillot, Bruno, Augeul, Lionel, Bolbos, Radu, Bongiovani, Antonino, Mewton, Nathan, Bochaton, Thomas, Ovize, Michel, Tardivel, Meryem, Kurdi, Mazen, Canet-Soulas, Emmanuelle, Da Silva, Claire Crola, and Bidaux, Gabriel
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- 2024
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41. Saudi Cerebral Palsy Register (SCPR): Protocol on the Methods and Technical Details
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Mushta, Sami Mukhdari, Alghamdi, Riyad, Almalki, Hani, Waqas, Saadia, Alawwadh, Adel, Barasheed, Osamah, Garnan, Mohammad, McIntyre, Sarah, Rashid, Harunor, Badawi, Nadia, and Khandaker, Gulam
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- 2024
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42. Effectiveness of epigallocatechin gallate nanoparticles on the in-vivo treatment of Alzheimer’s disease in a rat/mouse model: a systematic review
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Khalifa, Maha K. A., Abdel-Sattar, Somaia A., Amin, Omnya M., Kohaf, Neveen A., Zaky, Heba S., Abd El‑Fattah, Marwa A., Mohammed, Kamilia H. A., Badawi, Noha M., Mansoor, Ihab, and Eassa, Heba A.
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- 2024
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43. Physics-Informed Neural Network for the Transient Diffusivity Equation in Reservoir Engineering
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Badawi, Daniel and Gildin, Eduardo
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Physics - Fluid Dynamics - Abstract
Physics-Informed machine learning models have recently emerged with some interesting and unique features that can be applied to reservoir engineering. In particular, a physics-informed neural network (PINN) leverages the fact that neural networks are a type of universal function approximators that can embed the knowledge of any physical laws that govern a given data-set in the learning process, and can be described by partial differential equations. The transient diffusivity equation is a fundamental equation in reservoir engineering and the general solution to this equation forms the basis for Pressure Transient Analysis (PTA). The diffusivity equation is derived by combining three physical principles, the continuity equation, Darcy's equation, and the equation of state for a slightly compressible liquid. Obtaining general solutions to this equation is imperative to understand flow regimes in a porous media. Analytical solutions of the transient diffusivity equation usually are very hard to obtain due to the steep gradients of the pressure near the well. In this work we apply physics-informed neural networks to the one and two dimensional diffusivity equation and demonstrate that decomposing the space domain into very few subdomains can overcome the stiffness problem of the equation. Additionally, we demonstrate that the inverse capabilities of PINNs can estimate missing physics such as permeability and sealing fault similar to buildup tests without shutting in the well., Comment: 19 pages, Paper titled: "Physics-Informed Neural Network for the Transient Diffusivity Equation in Reservoir Engineering"
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- 2023
44. Super-resolution reconstruction of -ray CT images for PET-enabled dual-energy CT imaging
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Zhu, Yansong, Spencer, Benjamin A, Xie, Zhaoheng, Leung, Edwin K, Bayerlein, Reimund, Omidvari, Negar, Cherry, Simon R, Qi, Jinyi, Badawi, Ramsey D, and Wang, Guobao
- Subjects
Medical and Biological Physics ,Physical Sciences ,Biomedical Imaging ,Bioengineering ,4.2 Evaluation of markers and technologies ,Cancer ,PET-enabled dual-energy CT ,kernel MLAA ,patient study ,phantom study ,super-resolution ,Communications engineering ,Electronics ,sensors and digital hardware ,Atomic ,molecular and optical physics - Abstract
Dual-energy computed tomography (DECT) enables material decomposition for tissues and produces additional information for PET/CT imaging to potentially improve the characterization of diseases. PET-enabled DECT (PDECT) allows the generation of PET and DECT images simultaneously with a conventional PET/CT scanner without the need for a second x-ray CT scan. In PDECT, high-energy γ-ray CT (GCT) images at 511 keV are obtained from time-of-flight (TOF) PET data and are combined with the existing x-ray CT images to form DECT imaging. We have developed a kernel-based maximum-likelihood attenuation and activity (MLAA) method that uses x-ray CT images as a priori information for noise suppression. However, our previous studies focused on GCT image reconstruction at the PET image resolution which is coarser than the image resolution of the x-ray CT. In this work, we explored the feasibility of generating super-resolution GCT images at the corresponding CT resolution. The study was conducted using both phantom and patient scans acquired with the uEXPLORER total-body PET/CT system. GCT images at the PET resolution with a pixel size of 4.0 mm × 4.0 mm and at the CT resolution with a pixel size of 1.2 mm × 1.2 mm were reconstructed using both the standard MLAA and kernel MLAA methods. The results indicated that the GCT images at the CT resolution had sharper edges and revealed more structural details compared to the images reconstructed at the PET resolution. Furthermore, images from the kernel MLAA method showed substantially improved image quality compared to those obtained with the standard MLAA method.
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- 2024
45. Nanocomposites of spinel materials: synthesis, structural, optical and photoluminescent characteristics
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Heiba, Zein K., Farag, Noura M., Abozied, Asmaa M., Ali, Essam E., Badawi, Ali, and Mohamed, Mohamed Bakr
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- 2024
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46. Comparative study of neutralizing antibodies titers in response to different types of COVID-19 vaccines among a group of egyptian healthcare workers
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Sara Maher, Nihal M. El Assaly, Doaa Mamdouh Aly, Shimaa Atta, Asmaa Mohamed Fteah, Hala Badawi, Manal Youssef Zahran, and Manal Kamel
- Subjects
COVID-19 ,Neutralizing antibodies ,BNT162b2 ,Sinovac ,ChAdOx1 ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background Defining the protective thresholds against the severe-acute-respiratory-syndrome-related corona virus-2 pandemic is a crucial challenge. To reduce the risks of severe disease, hospitalization, and death, various COVID-19 vaccines have been rapidly developed. Aim of the work This study aimed to assess the impact of three common COVID-19 vaccine types; two mRNA COVID-19 vaccines: (Pfizer/BioNTech’s BNT162b2 and Moderna’s mRNA-1273), one adenoviral vector vaccine: Oxford/AstraZeneca’s ChAdOx1, and one inactivated vaccine (Sinovac Biotech/China’s Sinovac) on the level of neutralizing antibodies, considering factors such as vaccine type, demographic characteristics, and hybrid immunity. We conducted a direct comparative analysis involving 300 healthcare workers, both with and without prior SARS-CoV-2 infection (B.1, C.36.3, and AY.32 (Delta) variants). Neutralizing antibodies levels were measured at baseline (before vaccination), before the second dose, and six months after the second dose. Results The results showed a significant increase in neutralizing antibodies levels after complete vaccination with all vaccine types. Among healthcare workers, those vaccinated with mRNA vaccines (Moderna or Pfizer) exhibited the highest neutralizing antibodies titers, followed by AstraZeneca, and finally Sinovac with the lowest titer. On studying the effect of previous COVID-19 infection after vaccination, no significant difference in neutralizing antibodies levels was observed between healthcare workers vaccinated with mRNA or AstraZeneca vaccines, both with prior COVID-19 infection, following the first and six months after the second dose. Conclusion These findings suggest that individuals with prior COVID-19 may only require a single dose of mRNA or AstraZeneca vaccines to achieve a similar level of immunization as those without prior COVID-19 who completed the vaccination program. Highlights There is a significant increase in neutralizing antibodies levels after complete vaccination against COVID-19 Vaccination with mRNA vaccines exhibits the highest neutralizing antibodies titers. Vaccination with Sinovac exhibits the lowest neutralizing antibodies titers. Graphical abstract
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- 2024
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47. Diagnostic utility of testosterone priming prior to dynamic tests to differentiate constitutional delay in puberty from isolated hypogonadotropic hypogonadism in boys
- Author
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Shimaa Medhat Abdellatif Ahmed, Nora ElSaid Badawi, Mohamed Ahmed AbdElSalam, Lubna Fawaz, AbdelKarim Kamel, and Mona Mamdouh Hassan
- Subjects
Delayed puberty ,CDP ,IHH ,Testosterone priming ,Stimulation test ,Inhibin B ,Pediatrics ,RJ1-570 - Abstract
Abstract Background Differentiation between isolated hypogonadotropic hypogonadism (IHH) and constitutional delay in puberty (CDP) throughout adolescence can be challenging for doctors. This study examines the withdrawal effects of short-term, low-dose testosterone treatment (testosterone priming) on the ability of dynamic testing to distinguish between CDP and IHH based on activation of the hypothalamo-pituitary–testicular axis. Methods A case–control study included 20 boys with delayed puberty (group A) and 20 patients with IHH (group B). Both groups underwent Triptorelin and human chorionic gonadotropin (hCG) stimulation tests before and 2 months after testosterone injections (100 mg) intramuscularly every 4 weekly for 3 months. Results The triptorelin-stimulated 4-h LH with a cutoff of 2.4 IU/L and the hCG-stimulated testosterone with a cutoff of 1.160 ng/mL had sensitivities of 65% each, and specificities of 90% and 95%, respectively, to diagnose CDP. After testosterone withdrawal, the cut-off values for 4-h LH were 8.850 IU/L and 3.190 ng/mL for hCG-stimulated testosterone. Basal inhibin B > 88.25 pg/ml was found to be a differentiating factor in diagnosing CDP after testosterone withdrawal. Conclusions following the withdrawal of testosterone therapy, Inhibin B levels or 4-h stimulated LH are the most effective discriminant assays to distinguish CDP from IHH.
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- 2024
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48. Community-Acquired Pneumonia with Acute Kidney Injury Complicated by Rhabdomyolysis- A Challenging Case Report in Resource Limit Setting
- Author
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Mohamed IA, Omar AA, Hassan MA, and Badawi OH
- Subjects
community-acquired pneumonia ,acute kidney injury ,rhabdomyolysis ,resource limit setting. ,Medicine (General) ,R5-920 - Abstract
Ibrahim Abdullahi Mohamed,1 Abdullahi Abdirahman Omar,1 Mohamed Abdulahi Hassan,1 Omar Hassan Badawi2 1Department of Internal Medicine and Intensive Care Unit, Dr. Sumait Hospitals, Faculty Medicine and Health Sciences, SIMAD University, Mogadishu, Somalia; 2Department of Radiology, Dr. Sumait Hospital, Faculty Medicine and Health Sciences, SIMAD University, Mogadishu, SomaliaCorrespondence: Ibrahim Abdullahi Mohamed, Email dr.ibrahim@simad.edu.soBackground: Community-acquired pneumonia (CAP) is a common infectious disease that can lead to complications such as rhabdomyolysis (RM), a rare but potentially life-threatening condition involving muscle breakdown. RM can further complicate the clinical course by causing acute kidney injury (AKI). We present a case of Community-acquired pneumonia with AKI complicated by rhabdomyolysis in a resource-limited setting.Case Presentation: A 67-year-old male presented with high fever, cough, and shortness of breath. He had no significant medical history. On examination, he was febrile, tachypneic, and tachycardic, with right-sided lung crackles. Lab tests showed elevated inflammatory markers and impaired kidney function. Chest radiography revealed right upper lobe consolidation, confirming pneumonia and AKI. He was treated with fluids, antibiotics, and supportive care, but his condition worsened, requiring intensive care unit (ICU). In the ICU, dark urine and elevated creatine kinase confirmed rhabdomyolysis. After aggressive fluid therapy and antibiotics the patient improved over six days and was transferred to the ward. By day 10, he fully recovered and was discharged with follow-up.Conclusion: This case underscores the importance of early recognition and prompt management of CAP complicated by AKI and rhabdomyolysis, even in resource-limited settings. Timely intervention can lead to favorable outcomes despite challenges.Keywords: community-acquired pneumonia, acute kidney injury, rhabdomyolysis, resource limit setting
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- 2024
49. Tubulocystic renal cell carcinoma: A case report of rare tumor
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Abdullah M. Al-Jubouri, Ibrahim A. Khalil, Abdelkareem Alhyari, Majd Alkabbani, Alaeddin Badawi, Rajen Goyal, and Khalid Al Jalham
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Tubulocystic ,Renal cell carcinoma ,Nephrectomy ,Robotic ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Tubulocystic renal cell carcinoma (RCC) is a rare renal cancer first recognized by the WHO in 2016 as independent disease category, characterized by its typically indolent features and low rates of metastasis. We present a 35-year-old male with tubulocystic RCC diagnosed incidentally on evaluation of flank pain. Magnetic resonance imaging showed Bosniak class 4 renal cyst, although initial computed topography showed a hypodense nonenhancing lesion classified as Bosniak 1 cyst. Patient underwent robotic assisted partial nephrectomy, histopathology confirmed as tubulocystic RCC. This case highlights the importance of considering tubulocystic RCC in the differential diagnoses of renal cysts and other solid renal masses to ensure timely and effective treatment plan.
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- 2024
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50. Antiparasitic and apoptotic modulatory activities of curcumin and extracts of Nigella sativa L, Zingiber officinale Rosc., and Punica granatum L. in combination with spiramycin against chronic cerebral toxoplasmosis in immunocompromised mice
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Mennat-Elrahman A. Fahmy, Amany A. Abdel-Aal, Soad I. Hassan, Maisa A. Shalaby, Manal Badawi, and Marwa Esmat
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Medicinal plants ,Toxoplasma gondii ,ME-49 ,Punica granatum L ,Cerebral caspase-3 ,Miscellaneous systems and treatments ,RZ409.7-999 - Abstract
Objective: To examine the effect of coadministration of different medicinal plant extracts (curcumin and extracts of Nigella sativa L. [N. sativa, Jia Hei Zhong Cao], Zingiber officinale Rosc. [Z. officinale, Sheng Jiang], and Punica granatum L. [P. granatum, Shi Liu]) with spiramycin (SP) against the cystogenic ME-49 Toxoplasma gondii (T. gondii) strain in immunocompromised mice. Methods: We utilized 68 mice categorized into 8 groups: 2 non-infected controls (immunocompetent and immunocompromised), 1 infected control, and 5 infected and treated groups. Following the experiment, the cerebral tissues of each mouse underwent parasitological, histopathological, and immunohistochemical evaluations. Results: Compared with the infected non-treated group, all infected treated groups showed significant reductions in brain cyst numbers (all P
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- 2024
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