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Purpose: Nowadays, regenerative endodontics treatment is recommended in the case of loss of vitality of the dental pulp and the presence of a suitable dental structure. One of the primary reasons for failure after regenerative endodontics treatments is the remaining of bacteria in the root canal. Thus, to improve the prognosis of root canal treatment, it is recommended to use different intracanal medicaments including antibiotics and calcium hydroxide as complementary agents. This study aimed to review common intracanal medicaments in the treatment of endodontic regeneration. Materials and Methods: In this review study, the keywords of regenerative endodontics, pulp revascularization, paste antibiotic, intracanal medicament, and calcium hydroxide were searched in the Google, Google Scholar, PubMed, SID, ISI Web of Science, and IranMedex databases from 2018 to 2023. Articles that met the inclusion criteria were included in this study. Results: 39 studies were included in this study. Common intracanal medicaments (triple, double antibiotic pastes, calcium hydroxide, etc.) that are commonly used in regenerative endodontic treatment were used. Both the concentration and duration of exposure to the medicaments affect the viability of stem cells. TAP (Triple Antibiotic Paste) has the highest antibacterial effect against E. faecalis and the highest rate of discoloration. Calcium hydroxide as a medicament will probably have a positive impact on the release of growth factors. Conclusion: It is better to use antibiotic medicaments with a lower concentration at times between 24 hours and 48 hours for dental root canal disinfection so it does not interfere with the viability of stem cells. [ABSTRACT FROM AUTHOR]

Statement of the Problem: The most common cause of endodontic treatment failures is improper coronal sealing. Therefore, besides to proper root sealing, coronal sealing which is supported by a proper restoration has a major role in endodontic treatment success, and coronal microleakage should be considered as an etiologic factor in endodontic treatment failure. Glass-ionomer (GI) has been proposed as a coronal barrier for microleakage after endodontic treatment. Purpose: This study aimed to evaluate the coronal microleakage in GI-obturated root canals in endodontically treated teeth using different thicknesses of GI. Materials and Method: In this in vitro study, forty-five single-rooted extracted human teeth with single canals were collected and disinfected with 0.5% chloramine solution. After endodontic treatment, teeth were divided into 3 groups. In the group 1 to 3, 1 to 3mm of gutta-percha was removed and GI was replaced at 1-, 2- and 3-mm thicknesses respectively. Then subgroups were placed in methylene blue dye and the microleakage was assessed using dye penetration. Results: The mean dye penetration in groups 1, 2 and 3 were 5.1, 3.7 and 2.9, respectively, with statistically significant differences. Group 1 exhibited the highest amount of dye penetration while group 3 showed the least one. Moreover, a significant difference between groups 1 and 2 (p= 0.002) and a non-significant difference between groups 2 and 3 (p= 0.098) was detected in mean dye penetration. Conclusion: Thicker layers of GI might decrease the coronal microleakage. GI at 3- mm thickness resulted in the best protective effect on coronal microleakage in endodontically treated teeth, though further studies are needed to confirm these results. [ABSTRACT FROM AUTHOR]