A review of common intracanal medicaments in endodontic regeneration treatments.

Purpose: Nowadays, regenerative endodontics treatment is recommended in the case of loss of vitality of the dental pulp and the presence of a suitable dental structure. One of the primary reasons for failure after regenerative endodontics treatments is the remaining of bacteria in the root canal. Thus, to improve the prognosis of root canal treatment, it is recommended to use different intracanal medicaments including antibiotics and calcium hydroxide as complementary agents. This study aimed to review common intracanal medicaments in the treatment of endodontic regeneration. Materials and Methods: In this review study, the keywords of regenerative endodontics, pulp revascularization, paste antibiotic, intracanal medicament, and calcium hydroxide were searched in the Google, Google Scholar, PubMed, SID, ISI Web of Science, and IranMedex databases from 2018 to 2023. Articles that met the inclusion criteria were included in this study. Results: 39 studies were included in this study. Common intracanal medicaments (triple, double antibiotic pastes, calcium hydroxide, etc.) that are commonly used in regenerative endodontic treatment were used. Both the concentration and duration of exposure to the medicaments affect the viability of stem cells. TAP (Triple Antibiotic Paste) has the highest antibacterial effect against E. faecalis and the highest rate of discoloration. Calcium hydroxide as a medicament will probably have a positive impact on the release of growth factors. Conclusion: It is better to use antibiotic medicaments with a lower concentration at times between 24 hours and 48 hours for dental root canal disinfection so it does not interfere with the viability of stem cells. [ABSTRACT FROM AUTHOR]