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AIM: To assess the gap between the peak of the base curve to the surface of the cornea, as well as examines the correlation between the thickness of the tear film and the fitting of the orthokeratology lens through optical coherence tomography(OCT), providing an intuitive and quantitative clinical evaluation method for the fitting of the orthokeratology lens.METHODS: Myopia patients who fitted orthokeratology at our hospital from January to December 2023 were included. Examinations, including naked vision, slit lamp, non-contact intraocular pressure, ocular fundus, eye position, corneal diameter, corneal topography, tear film rupture time, optometry, etc., were performed on all patients before fitting. The trial lens parameter was selected according to the examination results, and fluorescein staining was performed to evaluate lens fitting state after patients adapted to wearing glasses. According to the performance of fluorescein staining, the inspected eyes are divided into three groups: lens loose group, lens fitting group, and lens tight group. In addition, the tear film thickness of three groups of subjects was measured by OCT, and the differences between the three groups of data were evaluated.RESULTS: A total of 49 myopic patients(77 eyes)were included. The average sphere degree was -3.10±1.25 D, the average cylinder degree was -0.43(-0.75, 0)D, the average horizontal keratometry(HK)was 42.48±0.81 D, and vertical keratometry(VK)was 42.98(42.25, 43.50)D. There were 21 cases(34 eyes)in the lens fitting group, with 13 cases of bilateral eyes, 8 cases of one eye, 14 cases(22 eyes)in the lens loose group, with 8 cases of bilateral eyes, 6 cases of one eye, and 14 cases(21 eyes)in the lens tight group, with 7 cases of bilateral eyes, 7 cases of one eye. There was no statistical difference in the main basic data of the subjects in the three groups(all P>0.05). OCT showed that the tear film thickness of the lens fitting group, the lens loose group, and the lens tight group was 231.18(219.0, 243.0), 220.41(214.0, 224.3), and 249.00(241.5, 258.0)μm, respectively, and there was statistical significance in the thickness among the three groups(P

To investigate the renal function and fibrosis indexes of conventional western medicine with Chinese medicine for dredging collaterals in the treatment of renal fibrosis (RF). We searched articles from databases (PubMed, Embase, The Cochrane Library, CNKI, and Wanfang data) and references of included studies. The quality of literature was evaluated and data were extracted in regard to the inclusion and exclusion criteria. RevMan5.3 software was applied for all statistical analyses. Eleven eligible RCTs with a total of 898 patients were included in this meta-analysis. Compared with conventional western medicine alone, conventional western medicine with Chinese medicine for dredging collaterals in the treatment of RF has lower BUN levels and SCr levels (P < 0.05). As for fibrosis indexes, conventional western medicine with Chinese medicine for dredging collaterals has lower HA, laminin (LN), IV-Col, and PC-III levels (P < 0.05). Conventional western medicine with Chinese medicine for dredging collaterals with lower BUN, Scr, HA, LN, PC-III, and IV-Col levels, has an advantage in the treatment of RF. These lower serum levels may not be associated with the presence of RF. Ideally, kidney biopsies should be performed to confirm that these markers reduce RF. This is a major limitation of this study.

C16H14Cl2O5, orthorhombic, P212121 (no. 19), a = 8.6429 (4) Å, b = 11.3361 (6) Å, c = 33.9029 (11) Å, V = 3321.7 (3) Å3, Z = 8, R gt(F) = 0.0635, wR ref(F 2) = 0.1630, T = 293(2) K.

Renal fibrosis (RF) is an important pathogenesis for renal function deterioration in chronic kidney disease. Secreted frizzled-related protein 5 (SFRP5) is an anti-fibrotic adipokine but its direct role on RF remains unknown. It was aimed to study the protective effect of SFRP5 against RF and interference with Wnt/β‐catenin signaling pathway for the first time. First, the therapeutic efficacy of SFRP5 was evaluated by adenovirus overexpression in rats with unilateral ureteral obstruction (UUO) in vivo. Thirty-six rats were randomly divided into the sham, UUO, and SFRP5 (UUO + Ad-SFRP5) groups. Half rats in each group were selected at random for euthanasia at 7 days and the others until 14 days. Then, the transforming growth factor (TGF)-β1-induced epithelial–mesenchymal transition (EMT) was established in HK-2 cells in vitro. The cells were divided into four groups: the control group, the TGF-β1 group, the TGF-β1 + SFRP5 group, and the TGF-β1 + SFRP5 + anti-SFRP5 group. The makers of EMT and Wnt/β‐catenin pathway proteins were investigated. In the UUO model, expression of SFRP5 showed compensatory upregulation, and adenoviral-mediated SFRP5 over-expression remarkably attenuated RF, as demonstrated by maintenance of E-cadherin and suppression of α-smooth muscle actin (SMA). In vitro, SFRP5 was shown to inhibit TGF-β1-mediated positive regulation of α-SMA, fibronectin, collagen I but negative regulation of E-cadherin. Furthermore, SFRP5 abrogated activation of Wnt/β-catenin, which was the essential pathway in EMT and RF pathogenesis. The changes after a neutralizing antibody to SFRP5 confirmed the specificity of SFRP5 for inhibition. These findings suggest that SFRP5 can directly ameliorate EMT and protect against RF by inhibiting Wnt/β-catenin pathway.

Improving the reproducibility of biomedical research results is a major challenge. Transparent and accurate reporting of the research process enables readers to evaluate the reliability of the research results and further explore the experiment by repeating it or building upon its findings. The ARRIVE 2.0 guidelines, released in 2019 by the UK National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs), provide a checklist that is applicable to any in vivo animal research report. These guidelines aim to improve the standardization of experimental design, implementation, and reporting, as well as enhance the reliability, repeatability, and clinical translation of animal experimental results. The use of the ARRIVE 2.0 guidelines not only enriches the details of animal experimental research reports, ensuring that information on animal experimental results is fully evaluated and utilized, but also enables readers to understand the content expressed by the author accurately and clearly, promoting the transparency and completeness of the fundamental research review process. At present, the ARRIVE 2.0 guidelines have been widely adopted by international biomedical journals. This article is based on the best practices following the ARRIVE 2.0 guidelines in international journals, and it interprets, explains, and elaborates in Chinese the fifth part of the comprehensive version of the ARRIVE 2.0 guidelines published in PLoS Biology in 2020 (the original text can be found at https://arriveguidelines.org). This section includes the items 6-11 of Recommended 11 section, covering "Animal Care and Monitoring", "Interpretation/Scientific Implications", "Generalisability/Translation", "Protocol Registration", "Data Access" and "Declaration of Interests". Its aim is to promote a comprehensive understanding and use of the ARRIVE 2.0 guidelines among domestic researchers, to enhance the standardization of experimental animal research and reporting, and to promote high-quality development of experimental animal sciences and comparative medicine research in China.

Annotation: The red line represents inhibition; Blue represents improvement

Improving the reproducibility of biomedical research results is a major challenge.Transparent and accurate reporting of the research process enables readers to evaluate the reliability of the research results and further explore the experiment by repeating it or building upon its findings. The ARRIVE 2.0 guidelines, released in 2019 by the UK National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs), provide a checklist applicable to any in vivo animal research report. These guidelines aim to improve the standardization of experimental design, implementation, and reporting, as well as the reliability, repeatability, and clinical translatability of animal experimental results. The use of ARRIVE 2.0 guidelines not only enriches the details of animal experimental research reports, ensuring that information on animal experimental results is fully evaluated and utilized, but also enables readers to understand the content expressed by the author accurately and clearly, promoting the transparency and integrity of the fundamental research review process. At present, the ARRIVE 2.0 guidelines have been widely adopted by international biomedical journals. This article is a Chinese translation based on the best practices of international journals following the ARRIVE 2.0 guidelines in international journals, specifically for the complete interpretation of the ARRIVE 2.0 guidelines published in the PLoS Biology journal in 2020 (original text can be found at https://arriveguidelines.org). The fourth part of the article includes the items 1-5 of ARRIVE 2.0 Recommended 11 section, which covers "Abstract" "Background" "Objectives" "Ethical statement" and "Housing and husbandry". Its aim is to promote the full understanding and use of the ARRIVE 2.0 guidelines by domestic researchers, enhance the standardization of experimental animal research and reporting, and promote the high-quality development of experimental animal technology and comparative medicine research in China.

Objective: To improve the storage safety of Xinjiang fresh walnut. Methods: Xinjiang "Xin 2" thin-skinned walnut was used as material, sterile water was inoculated as a control group, and Aspergillus flavus was inoculated as an experimental group. The Aspergillus flavus isolated and purified from naturally moldy walnut was artificially inoculated into Xinjiang thin-skinned fresh walnut with different water content （10%, 15%, 20%, 25%, 30%） to investigate the growth and toxicity of Aspergillus flavus. Results: The water content of walnut which was suitable for the growth of Aspergillus flavus and the secretion of Aflatoxin M1 was 15%. With the increase of walnut water content, the growth of Aspergillus flavus increased first and then decreased, but the growth of each water content was different, and the growth of Aspergillus flavus was proportional to the content of Aflatoxin M1. Conclusion: The water content of raw materials is closely related to the growth of Aspergillus flavus and the content of Aflatoxin M1 produced.

To review the clinical data of a patient with myelodysplastic syndrome and summarize the experience of treatment and nursing under the integrated mode of medical care. In the integrated medical and nursing ward rounds, doctors carried out symptomatic diagnosis and treatment, and used bedside physical examination combined with Traditional Chinese medicine. Nurses gave care based on syndrome differentiation, intradermal acupuncture treatment and moxibustion treatment intervention, and improved psychological evaluation and health education. In addition, patients were encouraged to actively cooperate with treatment and care. The implementation of integrated ward rounds can effectively improve the adverse reactions of chemotherapy in patients with myelodysplastic syndrome, improve treatment compliance, promote rehabilitation, and enhance the quality of nursing services. The integrated medical and nursing ward rounds is beneficial for the enhancement of medical care cooperation, sense of participation among nursing workers, and is conducive to the improvement of nursing quality. (本文回顾1例骨髓增生异常综合征患者的临床资料, 总结医护一体化模式下的治疗和护理经验。医护一体化模式下, 医生开展对症诊疗, 采用床旁查体联合中药方剂治疗; 护士实施辨证施护, 给予皮内针治疗及艾条灸治疗干预, 并完善心理评估和健康教育。此外, 鼓励患者积极配合治疗和护理。实施医护一体化查房, 能有效缓解骨髓增生异常综合征患者化疗的不良反应, 提高治疗依从性, 促进康复, 提升护理服务质量。医护一体化查房加强了医护合作, 可提升护理工作者的参与感, 进而有利于护理质量的提升。)

Recent studies revealed that endoplasmic reticulum (ER) stress played an emerging role of in valve calcification. Tanshinone IIA (TanIIA) has been a research hotspot in cardiovascular diseases. Previously we found that sodium TanIIA dampened the pathological phenotype transition of valvular interstitial cells (VICs) by affecting ER stress published in Chinese Journal. Here, we test the hypothesis that TanIIA attenuates the pro-osteogenic effects of oxidized low-density lipoprotein (oxLDL) in VICs by reducing induction of ER stress. Patients’ aortic valve (AV) was collected, and porcine VICs were cultured for in vitro model. ER stress markers were tested in human leaflets by immunostaining. Immunoblotting were used to test the osteoblastic factors such as Runx2, osteocalcin, and ER stress markers GRP78, CHOP, XBP1, etc. Alkakine phosphate (ALP) activity assay were used to test the activity of ALP kinase. Pro-inflammatory gene expression was detected by polymerase chain reaction. As a result, ER stress markers were elevated in patients’ calcified AVs. OxLDL induced osteogenesis and inflammation via promoting ER stress. TanIIA attenuated oxLDL induced ER stress. TanIIA also inhibited theosteoblastic factors and inflammatory cytokine expressions in VICs. In conclusion, our data provide evidence that TanIIA exerts anti-inflammation and anti-osteogenic effects in VICs by attenuating ER stress, and ER stress acts as an important regulator in oxLDL induced VICs’ phenotype transition.

Improving the reproducibility of biomedical research results is a major challenge.Researchers reporting their research process transparently and accurately can help readers evaluate the reliability of the research results and further explore the experiment by repeating it or building upon its findings. The ARRIVE 2.0 guidelines, released in 2019 by the UK National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs), provide a checklist applicable to any in vivo animal research report. These guidelines aim to improve the standardization of experimental design, implementation, and reporting, as well as the reliability, repeatability, and clinical translatability of animal experimental results. The use of ARRIVE 2.0 guidelines not only enriches the details of animal experimental research reports, ensuring that information on animal experimental results is fully evaluated and utilized, but also enables readers to understand the content expressed by the author accurately and clearly, promoting the transparency and integrity of the fundamental research review process. At present, the ARRIVE 2.0 guidelines have been widely adopted by international biomedical journals. This article is a Chinese translation based on the best practices of international journals following the ARRIVE 2.0 guidelines in international journals, specifically for the complete interpretation of the ARRIVE 2.0 guidelines published in the PLoS Biology journal in 2020 (original text can be found at https://arriveguidelines.org). The third part of the article includes the items 8-10 of ARRIVE 2.0 Essential 10, which covers "experimental animals" "experimental procedures" and "results". Its aim is to promote the full understanding and use of the ARRIVE 2.0 guidelines by domestic researchers, enhance the standardization of experimental animal research and reporting, and promote the high-quality development of experimental animal technology and comparative medicine research in China.

To explore the role of NAC transcription factors in mung bean (Vigna ratiata), we here comprehensively analyzed VrNAC13 structure and expression patterns in the mung bean cultivar “Yulin No.1”. The nucleotide sequence of VrNAC13 (GenBank accession number xp014518431.1) was determined by cloning and sequencing the gene. A predicted transcriptional activation domain in VrNAC13 was validated with a yeast one-hybrid assay. The composition and functional characteristics of VrNAC13 were analyzed using basic bioinformatics techniques, and the expression characteristics of VrNAC13 were analyzed via quantitative reverse transcription-PCR. The results showed that VrNAC13 was 1,068 bp in length and encoded a product of 355 amino acids. VrNAC13 was predicted to contain a NAM domain and to belong to the NAC transcription factor family. The protein was hydrophilic and contained several threonine phosphorylation sites. Phylogenetic analysis showed that VrNAC13 was highly similar in sequence to two Arabidopsis thaliana NAC proteins; we hypothesize that VrNAC13 may perform functions in mung bean similar to those of the two closely related proteins in Arabidopsis. Promoter analysis of VrNAC13 revealed cis-acting elements predicted to respond to abscisic acid (ABA), gibberellin, auxin, light, drought, low temperature, and other stressors. VrNAC13 was most highly expressed in the leaves and expressed at very low levels in the stem and root. It was experimentally determined to be induced by drought and ABA. Based on these results, VrNAC13 appears to regulate stress resistance in mung bean.

Improving the reproducibility of biomedical research results remains a major challenge. Transparent and accurate reporting of progress can help readers evaluate the reliability of research results and further explore an experiment by repeating or building upon its findings. The ARRIVE 2.0 guidelines, released in 2019 by the UK National Centre for the Replacement, Refinement, and Reduction of Animals in Research (NC3Rs), provide a checklist applicable to any in vivo animal research report. These guidelines aim to improve the standardization of experimental design, implementation, and reporting, as well as the reliability, repeatability, and clinical translatability of animal experimental results. The use of the ARRIVE 2.0 guidelines not only enriches the details of animal experimental research reports, ensuring that information on animal experimental results is fully evaluated and utilized, but also enables readers to understand the content expressed by the author accurately and clearly, promoting the transparency and integrity of the fundamental research review process. At present, the ARRIVE 2.0 guidelines have been widely adopted by international biomedical journals. This article is the second part of the Chinese translation of the complete interpretation of the ARRIVE 2.0 guidelines published in PLoS Biology in 2020 (original text can be found at https://arriveguidelines.org) and based on the best practices for following the ARRIVE 2.0 guidelines in international journals. This part includes Items 4-7 of "ARRIVE Essential 10" in the ARRIVE 2.0 guidelines: "Randomization", "Blinding", "Outcome Measurement", and "Statistical Methods". Our Chinese translated version aims to promote the full understanding and use of the ARRIVE 2.0 guidelines by domestic researchers, enhancing the standardization of experimental animal research and reporting, and promoting the high-quality development of experimental animal technology and comparative medicine research in China.

Improving the reproducibility of biomedical research results is a major challenge. Researchers reporting their research process transparently and accurately can help readers evaluate the reliability of the research results and further explore the experiment by repeating it or building upon its findings. The ARRIVE 2.0 guidelines, released in 2019 by the UK National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs), provide a checklist applicable to any in vivo animal research report. These guidelines aim to improve the standardization of experimental design, implementation, and reporting, as well as the reliability, repeatability, and clinical translatability of animal experimental results. The use of ARRIVE 2.0 guidelines not only enriches the details of animal experimental research reports, ensuring that information on animal experimental results is fully evaluated and utilized, but also enables readers to understand the content expressed by the author accurately and clearly, promoting the transparency and integrity of the fundamental research review process. At present, the ARRIVE 2.0 guidelines have been widely adopted by international biomedical journals. this article is a Chinese translation based on the best practices of international journals following the ARRIVE 2.0 guidelines in international journals, specifically for the complete interpretation of the ARRIVE 2.0 guidelines published in the PLoS Biology journal in 2020 (original text can be found at https://arriveguidelines.org). The first part of the article includes the preface and the "Key 10" section, which covers "study design" "sample size" and "inclusion and exclusion criteria". Its aim is to promote the full understanding and use of the ARRIVE 2.0 guidelines by domestic researchers, enhance the standardization of experimental animal research and reporting, and promote the high-quality development of experimental animal technology and comparative medicine research in China.

As rubber is a hyperelastic material, its nonlinear deformation behavior during aging is significantly influenced by various factors, including the material characteristics, demonstrating a significant uncertainty. Most of the existing uncertain prediction methods of rubber nonlinear property degradation are based on the probability density function, which requires a large number of samples to obtain the probability distribution and requires a lot of work. Therefore, the interval model is used in this study to characterize the uncertainty. However, the traditional interval constitutive models ignore the correlation between interval variables, and the prediction results have large errors. In order to minimize prediction errors and improve prediction accuracy, an interval Mooney–Rivlin (M–R) correlation model that considers the correlation between parameters was established. To address the influence of uncertainties, an interval Arrhenius model was constructed. The M–R model requires multiple fittings of stress–strain curves to obtain the model parameters, and the prediction process is relatively complex. Therefore, combing the two proposed models, the relationship equations of rubber tensile stress with aging temperature and aging time were first established by interval Arrhenius, and then the interval M–R model was used to obtain the variation ranges of parameters C10{C}_{10} and C01{C}_{01}. By contrasting this with the measured rubber aging information, the effectiveness of the proposed model was confirmed. Compared with the prediction model based on the average value, the maximum error of prediction of this model is reduced by about 60%. Compared with the traditional interval model, the prediction region is significantly reduced, which further improves the prediction accuracy. The above results indicate that this interval aging lifetime prediction model is suitable for characterizing the nonlinear stress–strain behavior of rubber-like elastomers.

Environmental pollution is one of the most significant public concerns in modern society, which is harmful to ecology and human health directly or indirectly. Among different types of environmental pollutants, environmental endocrine disruptors, drugs and personal care products are more serious in water and soil. In order to deal with the residues of environmental pollutants and avoid their long-term potential harm to human health, there is an urgent need to develop a rapid and accurate method for analyzing and monitoring environmental pollutants. As one of ambient ionization mass spectrometry, direct analysis in real time mass spectrometry (DART-MS) has the advantage of ease of use, rapid analysis and minimum sample preparation. It can realize fast sampling under ambient conditions and serve a promising technique for environmental pollutant screening. In this review, the principle of DART-MS and its characteristics were introduced firstly, and then the application of DART-MS in the detection of pesticide residues, veterinary drugs and abused drugs, and environmental pollutants were briefly summarized. Finally, methodology and application of DART-MS in the screening of environmental pollutants were prospected.

The two-dimensional finite element microscopic model of NiCoCrAlY/YSZ gradient thermal barrier coating was established by using the representative volume element method to calculate the thermophysical properties of the gradient layer under different composition ratios. The parameter results were extended to the three-dimensional multi-layer solid model to study the thermodynamic properties of the double-layer coating and gradient structured coating under thermal cycling condition. The results show that the elastic modulus, Poisson's ratio, coefficient of thermal expansion and thermal conductivity of the gradient layer are approximately linear with the component proportion of each phase, and the thermal conductivity is also affected by the distribution pattern of each phase. The thermal conductivity is low and the highest value is 2.91 W·m−1·K−1 when the proportion of NiCoCrAlY phase in the gradient layer is below 0.7 at room temperature. Compared with the double-layer coating, the proportion of YSZ in gradient coatings is reduced by 20%, the insulation temperature is reduced by 14%, the radial tensile stress, axial tensile stress, and shear stress of the ceramic surface layer at high temperature are reduced respectively by 47%, 32% and 37%, and the residual stress after cooling is reduced by 50%. The results are attributed that the gradient of the coating structure can effectively reduce the thermal mismatch stress caused by the difference in the thermal expansion coefficient between coating and substrate. According to the results of coating stress distribution, the coating is inclined to form vertical cracks in the centre region and horizontal cracks near the outer edge of the TC/BC interface.

Aiming at the low accuracy and efficiency of stochastic model updating, a stochastic finite element model updating method based on the Kriging model and wavelet packet energy spectrum was proposed. Firstly, assume that the parameters and response characteristics of the model to be updated obey normal distributions, the uncertainty model updating was transformed into the updating of mean and standard deviation. Secondly, the parameters to be updated were taken as inputs of Kriging model, the node energies extracted by the acceleration frequency response function after wavelet packet decomposition were taken as the outputs, the political optimizer algorithm was introduced to optimize the correlation coefficient to construct Kriging model. Then, minimize the absolute value of the difference between the test response and the predicted response as the objective function for updating mean, and minimize the cross entropy as the objective function for updating standard deviation, and updated the parameters mean and standard deviation through the political optimizer algorithm. Finally, taking a space truss structure as the example, the elastic modulus and density were selected as the parameters to be updated to verify the feasibility of the proposed method. The results show that the proposed method can effectively update the mean and standard deviation of structural parameters, and errors of the updated mean and standard deviation are less than 0.1% and 3.5%, respectively.

This paper summarizes the Traditional Chinese Medicine (TCM) ointment treatment and nursing management of a patient with bone pain induced by multiple myeloma. Nurses had evaluated the degree of bone pain and negative emotion of the patient before taking interventions. Based on the TCM basic theory, the TCM ointment treatment and emotional care were carried to relieve the pain, anxiety and depression, and improve the treatment compliance. (本文总结1例多发性骨髓瘤导致骨痛患者采用中药膏摩治疗的护理体会。护理人员评估患者疼痛负性情绪严重程度, 基于中医基础理论, 开展中药膏摩和情志干预, 有效减轻患者疼痛程度, 缓解焦虑、抑郁情绪, 提高了治疗依从性。)

C16H14Cl2O5, orthorhombic, P212121 (no. 19), a = 23.2297(5) Å, b = 16.3509(3) Å, c = 8.7300(2) Å, V = 3315.89(12) Å3, Z = 8, Rgt(F) = 0.0472, wRref(F2) = 0.1268, T = 293 K.

With the development of information and control technology, fully automatic operation system (FAO) has been widely adopted in the construction of new subway lines. Since the main line operating vehicles under FAO mode do not have driver posts, the dispatchers at the control center need to monitor the running status of all trains on the line in real time to ensure the correct operation of the trains. According to the characteristics of FAO mode , this paper designs a train dispatching system based on big data architecture. The system collects status data of train subsystems and processes and analyzes them based on big data framework,which realizes real-time status monitoring of vehicles on the whole line; and provides human-computer interaction interface for remote control, which meets the requirements of metro operation dispatcher for vehicle running status monitoring. The system has been verified by the third party security assessment, and its stability and availability meet the FAO line operation requirements.

On-chip optical communications are in increasingly demand for low-loss, small-footprint and power-efficient waveguiding solutions in the telecom band. However, most integrated optical circuits suffer from high propagation loss and low integration degree. Through manipulating the valley-dependent topological phase of light, we have experimentally demonstrated both robust optical transport and electrical modulation of lightwaves at telecom wavelengths in the valley photonic crystals. With the adoption of valley kink states, the 25 Gbit/s optical signal at 1550 nm is successfully transmitted through a highly twisted interface. Furthermore, an extreme high data rate of 100 Gbit/s is demonstrated with such topological waveguide by wavelength division multiplexing. The electrical tunability of the topological modulators based on thermo-optic effect is also verified, opening a novel route towards active valley kink photonic devices. Our study shows a great possibility of making use of the topological protection in building up high-speed datalinks on a chip.

Objective: Using Xinjiang melon as raw material, explore melon slices in weak microwave-assisted hot air drying in the process of drying characteristics. Methods: Using R2, χ2 and RMSE as evaluation indexes, compare melon slices of wet basis moisture content under different conditions, the drying rate, moisture content than the distinction, and melon dry dynamics model was set up, and the drying characteristic curve of melon slices was gotten at different slice thickness, the cycle time of microwave, the hot air cycle time. Results: The thinner the slice, the longer the circulation drying time of microwave and dry hot air, the faster the moisture content of the dry base decreased. The faster the drying rate, and the more the moisture ratio changes. The drying process of melon slice can be divided into two stages, accelerated drying and reduced drying, and accelerated drying was the main drying stage. Different slice thickness, microwave circulation time and dry-hot air circulation time, the Thompson equation can better reflect the drying characteristics and laws of melon slices. The R2 ranged from 0.992 9~0.999 9, χ2 ranged from 9.55×10-6~1.51×10-3, RMSE ranged from 0.002 68~0.027 47. The predicted values of Thompson equation were similar to the true ones, R2 was 0.995 0, χ2 was 3.93×10-4, and RMSE was 0.016 58. Conclusion: The model can be used to predict the moisture variation during the dry-hot air drying of melon slices.

China National Accreditation Service for Conformity Assessment (CNAS) laboratory animal institutions accreditation is an important system for the management of laboratory animals in China. It is a third-party evaluation on Chinese characteristics dedicated to ensuring the quality and welfare of laboratory animals in China. The American Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC) certification provides global services about animal welfare evaluation and ethical certification, which are important for management and use of laboratory animals. This study compared and analyzed the nature of CNAS and AAALAC, the nature of CNAS accreditation and AAALAC certification, the evaluation principles, required documents, the evaluation process, the management of reviewers, and the acceptance of results, and discussed the differences and characteristics of the two evaluation systems for laboratory animal institutions.

Objective To investigate the effects of lncRNA FENDRR on the proliferation, migration, invasion and apoptosis of LUSC H226 cells and its molecular mechanism. Methods The expression levels of FENDRR in normal lung epithelial cells BEAS, lung adenocarcinoma A549 and H1299 cells and LUSC H226 cells were detected by qRT-PCR. H226 cells were transfected with FENDRR-siRNA as the experimental group, or with FENDRR-siNC as a negative control group. Cell proliferation was detected by CCK-8 assay. Cell migration and invasion were detected by Transwell assay. Cell apoptosis was detected by flow cytometry. The protein expression levels of MEK, p-MEK, ERK and p-ERK were determined by Western blot. Results FENDRR levels in H226 cells were significantly lower than those in normal lung epithelial cells. Compared with the negative control group, the knockdown of FENDRR could significantly promote the proliferation, migration and invasion of H226 cells, inhibit the cell apoptosis, and increase the protein levels of p-MEK and p-ERK. The addition of ERK inhibitor U0126 rescued the effect of FENDRR knockdown on H226 cells. Conclusions The knockdown of lncRNA FENDRR can promote the proliferation, migration and inhibit the apoptosis of H226 cells through ERK/MAPK pathway.

With the continuous development of information technology, people's lifestyle and the quality of life have further improved, people's demand for medical and health is also increasing, "smart healthcare" happens to meet people's growing demand of medical and health services. This article briefly overviews of the development of smart healthcare, surrounded by the definition of smart healthcare, the development of smart healthcare, the role of smart healthcare, the safety of smart healthcare, and the prospect of smart healthcare.

Traditional methods for the optimization design of the air spring are based on the deterministic assumption that the parameters are fixed. However, uncertainties widely exist during the manufacturing stage of the air spring. To model the uncertainties in air springs, evidence theory is introduced. For the response analysis of the air spring system under evidence theory, an evidence theory-based polynomial chaos method, called the sparse grid quadrature-based arbitrary orthogonal polynomial (SGQ-AOP) method, is proposed. In the SGQ-AOP method, the response of the air spring is approximated by AOP expansion, and the sparse grid quadrature is introduced to calculate the expansion coefficient. For optimization of the air spring, a reliability-based optimization model is established under evidence theory. To improve the efficiency of optimization, the SGQ-AOP method is used to establish the surrogate model for the response of the air spring. The proposed response analysis and the optimization method were employed to optimize an air spring with epistemic uncertainties, and its effectiveness has been demonstrated by comparing it with the traditional evidence theory-based AOP method.

In order to increase the utilization value of Lavandula angustifolia (LA) residue and provide a theoretical basis for the development and utilization of LA waste, the extraction process of total triterpenoids from LA was optimized and its antioxidant activity was determined in vitro. Taking the yield of total triterpenes in LA as the evaluation index, the single factor experiments and the response surface methodology were used to optimize the extraction process of ultrasonic-assisted extraction of total triterpenes from LA. The results showed that the optimum extraction conditions were ethanol concentration 89%, ratio of material to liquid 1:33 (g/mL), extraction time 60 min, and ultrasonic power 70% (445 W). The theoretical extraction volume was 39.64 mg/g, and the actual one was (39.95±0.32) mg/g under this optimum condition, which was close to the predicted value. Afterwards, using VC as a control, DPPH free radical, OH free radical, and O2− free radical scavenging experiments were subjected to measure the anti-oxidant activity of total triterpenes, and their scavenging rates were 86.83%, 42.06% and 47.93%, respectively. After the optimization of the ultrasonic-assisted extraction process conditions, the total triterpenes extracted from LA is significantly increased, and the extract has strong antioxidant activity, which provides a theoretical basis for the reuse of LA waste to further tap the potential value.

Abstract Background The pathological diagnosis of bladder cancer workup relies on cystoscopy, however, due to sampling restriction, the depth of local invasion is often understaged. Methods A total of 386 patients with bladder urothelial carcinoma underwent follow-up. The data collected included age, sex, tumor size, surgical options, histologic grade, invasive depth, lymph node metastasis, and oncological outcomes, and the patients were divided into coral-like and crumb-like groups. These data were analyzed with the chi-square test, binary logistic regression, Kaplan–Meier analysis, univariable and multivariable logistic regression and Spearman correlation test. Results Bladder tumor morphology was moderately correlated with invasion depth (ρ = 0.492, p

In order to solve the problem of limited bandwidth and large overall size of leaky-wave antenna, a new wide-band leaky-wave antenna is proposed in this paper. The antenna is composed of surface plasmon polaritons transmission lines and asymmetric circular patches. It works at 7~15 GHz (relative bandwidth of 72.73%), enabling continuous beam scanning from backward to forward with a beam scanning angle of 69°and a stable high radiation gain. The maximum gain of the antenna in simulation reaches 13.1 dBi and the measured gain variation is only 1.64 dB. The test results are good agree with the simulation results. The proposed leaky-wave antenna has the advantages of simple structure, stable performance and easy fabrication. Furthermore, the overall size of the antenna is comparatively small, which makes it conducive to the conformable integration in wireless communication systems.

Abstract The nanofluids owing to their alluring attributes like enhanced thermal conductivity and better heat transfer characteristics have a vast variety of applications ranging from space technology to nuclear reactors etc. The present study highlights the Ostwald-de-Waele nanofluid flow past a rotating disk of variable thickness in a porous medium with a melting heat transfer phenomenon. The surface catalyzed reaction is added to the homogeneous-heterogeneous reaction that triggers the rate of the chemical reaction. The added feature of the variable thermal conductivity and the viscosity instead of their constant values also boosts the novelty of the undertaken problem. The modeled problem is erected in the form of a system of partial differential equations. Engaging similarity transformation, the set of ordinary differential equations are obtained. The coupled equations are numerically solved by using the bvp4c built-in MATLAB function. The drag coefficient and Nusselt number are plotted for arising parameters. The results revealed that increasing surface catalyzed parameter causes a decline in thermal profile more efficiently. Further, the power-law index is more influential than the variable thickness disk index. The numerical results show that variations in dimensionless thickness coefficient do not make any effect. However, increasing power-law index causing an upsurge in radial, axial, tangential, velocities, and thermal profile.

The peripherally inserted central catheter (PICC) is commonly used in the clinical setting, and PICC-related phlebitis is of great concern among doctors and nurses. This paper summarized the effect observation of 2% chlorhexidine gluconate solution wet compress in the treatment of PICC-related phlebitis and related nursing measures. The 2% chlorhexidine gluconate solution with characteristics of good antibacterial effect and less skin irritation is effective to relieve the syndrome of PICC-related phlebitis. (经外周静脉置入中心静脉导管(PICC)在临床应用广泛, PICC相关性静脉炎的防治是医护人员关注的重点问题。本文总结1例2%葡萄糖酸氯己定醇湿敷治疗PICC所致静脉炎的护理经验, 2%葡萄糖酸氯己定醇抗菌效果好、对皮肤刺激小等优点, 能有效改善静脉炎症状。)

Objective To summarize the clinical features and outcomes of patients with rhinocerebral mucormycosis involving cranial nerve. Methods and Results Eight pathologic confirmed cases of rhinocerebral mucormycosis with cranial nerves involvement since February 2012 to January 2020 were collected and evaluated. All patients were diagnosed at Beijing Tongren Hospital, Capital Medical University. The main clinical manifestations were headache, eye and face swelling. In addition to the paranasal sinuses, the ocular motor nerve, extraocular muscle, meninges, brain parenchyma, optic nerve, cerebrovascular and vestibulocochlear nerve were also involved. There were 5 patients with the primary disease of type 2 diabetes mellitus, one patient with acute leukemia receiving chemotherapy, one patient with severe aplastic anemia receiving immunosuppressive therapy, and one patient with craniocerebral trauma. Six patients were confirmed by pathological biopsy of paranasal sinus mucosa, the other 2 patients underwent brain parenchymal biopsy and temporal muscle biopsy respectively. In addition to one patient with meningeal involvement who gave up treatment and finally died, the other 7 patients received amphotericin B (one case was combined with posaconazole) or amphotericin B liposome antifungal therapy. Among them 4 patients underwent simultaneous transnasal endoscopic radical lesion removal treatment and 3 patients with brain parenchymal involvement died despite of active treatment. Conclusions The mortality of rhinocerebral mucormycosis with brain parenchyma involvement is extremely high. For patients with sinusitis with immunocompromised state, if there is acute progression of cranial nerve involvement, swelling around the eyes and headache, attention should be paid to the identification of the disease, and antifungal drugs and combined surgery treatment should be given early. Pathological biopsy of the affected mucosal tissue is the first choice for quick diagnosis.

This paper summarized the nursing experience of one case of insomnia treated by intradermal needle therapy. Based on the acupoint selection by syndrome differentiation, the intradermal needle therapy combined with auricular acupuncture was carried out to relief patient’s anxiety states and improve sleep quality. (本文总结 1 例皮内针改善失眠患者睡眠质量的护理经验, 包括中医辨证、皮内针操作方法以及注意事项等。通过采用皮内针体针与耳针相结合辨证取穴的方法治疗失眠, 能有有效缓解患者焦虑情绪, 改善睡眠质量。)

Considering the influence of structural parameter uncertainty on response and the problem of large calculation of stochastic model updating, a stochastic finite element model updating method based on polynomial chaotic expansion and KL divergence is proposed. Firstly, Kriging model is constructed instead of finite element model analysis, then polynomial chaotic expansion model is constructed based on probabilistic collocation method and regression analysis, and the functional relationship between uncertain structural parameters and response is established to quickly estimate the mean value and standard deviation of response. Finally, the mean value and standard deviation of structural parameters are modified to minimize KL divergence. Taking three-dimensional truss as an example, the mean value and standard deviation of elastic modulus and density are modified to verify the feasibility of the proposed method. The results show that the proposed method has high updating accuracy and efficiency.

This paper summarized the application experience of projective infrared angiography in venipuncture for a patients with myelodysplastic syndrome(MDS). Venipuncture guided by projective infrared angiography can not only improve the success rate of venipuncture, reduce the time of venous catheterization, but also improve the satisfaction of patients. (本文总结1例骨髓增生异常综合征患者静脉穿刺中运用投影式红外血管成像仪辅助穿刺的经验。投影式红外血管成像仪引导下进行静脉穿刺, 能够提高静脉穿刺成功率, 缩短静脉置管时间, 提高患者满意度。)

Active flow control for drag reduction in turbulent boundary layer is a hot research field nowadays. In order to explore the effect of the synthetic jet through a spanwise slot on the friction drag reduction of the turbulent boundary layer of a flat plate, the streamwise velocity are measured by a constant temperature hot-wire anemometer with and without synthetic jet. According to the measured experiment data, the mean velocity profiles, fluctuating velocity profiles, skewness and flatness are obtained respectively. Typical combinations of different frequencies and intensities of synthetic jet are selected to study the variation of the forcing effect in the streamwise direction. The experimental results show that the skin friction drag reduction in the turbulent boundary layer is related to the characteristics of the imposed synthetic jet and the distance between the local station and the slot. The synthetic jet leads to an increase of the skin friction drag in the station close to the slot, and as the flow moved downstream away from the slot, a reduction in the skin friction occurred with the tendency of firstly increasing and then decreasing. The reduction of skin friction caused by the synthetic jet of a higher frequency is more than that of a lower frequency. The power spectral density and autocorrelation of the fluctuating velocities indicate that the effect of the synthetic jet on the turbulent boundary layer decays in the streamwise direction.

Titanium/steel laminated composite plates were prepared by cold rolling method. The effects of rolling reduction, rolling speed, surface roughness, state of raw material and rolling pass on the interfacial bonding strength of titanium/steel laminated composite plates were studied. The results show that the interfacial action force and action time of rolling force on the interface are the main parameters affecting the interfacial bonding strength of titanium/steel laminated composite plates. The rolling reduction, surface roughness and state of raw material affect the interfacial bonding strength of titanium/steel laminated composite plate through affecting the interfacial action force. The rolling speed affects the interfacial bonding strength of titanium/steel laminated composite plate through affecting the action time of rolling force on the interface. Whether the titanium/steel laminated composite plate can be cold roll bonded or not has nothing to do with the number of rolling passes, only when the rolling reduction of single pass exceeds the critical rolling reduction can the cold roll bonded be realized.

It is very important to apply an effective method to predict the crystallization degree of laser 3D printed bulk metallic glasses (BMGs) for selecting and optimizing the processing parameters of laser 3D printing. In the present study, beginning with the kinetics of crystallization of amorphous alloys, the crystallization activation energy and Arrhenius factor were obtained by testing the characteristics of the temperature of the amorphous alloy under different heating rates, then a novel method of predicting the volume fraction of crystallization for the metallic glass produced by laser 3D printing was proposed combined with the finite element simulation technology. The validity of the method was verified by using Zr50Ti5Cu27Ni10Al8(Zr50) amorphous alloy as the model system. The result shows that the volume fraction of the crystalline phase of the single-track Zr50 BMG obtained by this method is 1.23%, which is very close to the experimentally obtained crystallization phase volume fraction of 1.65%. This strongly proves the effectiveness of the theoretical prediction method for the crystallization volume fraction of laser 3D printing BMGs.

Rural planning is to make the countryside neat and tidy through planning, including farmland planning and sewage discharge planning. All individual buildings shall not be built outside the planned area or the construction land at will, and shall not be built in the demolition area with incomplete infrastructure. The planning and construction of pits and ponds shall be implemented to control agricultural pollution. The overall deployment of long-term social, economic, scientific and technological development is the basic basis for guiding rural development and construction.

The mechanism of coating interface bulge on the TGO growth behavior was studied by analyzing the rule of TGO growth and the interface stress at the top coat/bond coat interface. The results show that the growth rate of TGO in the convex region of the top coat/bond coat interface is higher than that in the other regions. According to the stress analysis of ANSYS, the interface stress increases (from 185 MPa to 406 MPa) with the increase of roughness (from 10 μm to 20 μm). Additionally, the interfacial stress also increases (from 142 MPa to 574 MPa) with the thickness of TGO layer increasing (from 1.6 μm to 9.3 μm). What’s more, during high temperature oxidation, the convex region of the top coat/bond coat interface is mainly characterized by tensile stress and the depressed region is compressive stress.The tensile stress can promote the rapid growth of TGO layer, while the compressive stress exhibits the inhibition on the growth rate of TGO. In summary, reducing the roughness of bond coat can reduce the interface stress and slow the growth rate of TGO, which ensures the effective bonding strength of the coating. Thus, the stability of the TBCs at high temperature can be improved.

Ni-graphite abradable seal coatings were deposited by conventional atmospheric plasma spraying system (APS) and high efficiency supersonic atmospheric plasma spraying system (SAPS) respectively. The influence of the size of lubrication phase on mechanical properties, corrosion resistance and erosion resistance of the Ni-graphite coatings was investigated. The results indicate that the graphite phase in the SAPS coating has a smaller size than the APS coating. The bonding strength (21.0 ± 1.4) MPa and surface hardness (92 ± 1) HR15Y of SAPS coating are 29.6 % and 23.5 % higher than those of APS coating respectively. The relative erosion rates of APS coating at 30° and 90° angle of attack are 7 % and 13% higher than those of SAPS coating respectively, indicating that SAPS coating has a better erosion resistance than APS coating. Both APS coating and SAPS coating exhibit an obvious electrochemical corrosion in acetic acid environment at 250 ℃．However, the corrosion resistance of SAPS coating is better than that of APS coating.

Conventional calibration methods used in hydrological modelling are based on runoff observations at the basin outlet. However, calibration with only runoff often produces reasonable runoff but poor results for other hydrological variables. Multi-variable calibration with both runoff and remote sensing-based evapotranspiration (ET) is developed naturally, due to the importance of ET and its data availability. This study compares two main calibration schemes: (1) calibration with only runoff (Scheme I) and (2) multi-variable calibration with both runoff and remote sensing-based ET (Scheme II). ET data are obtained from three remote sensing-based ET datasets, namely Penman–Monteith–Leuning (PML), FLUXCOM, and the Global Land Evaporation Amsterdam Model (GLEAM). The aforementioned calibration schemes are applied to calibrate the parameters of the Distributed Hydrology Soil Vegetation Model (DHSVM) through ε-dominance non-dominated sorted genetic algorithm II (ε-NSGAII). The results show that all three ET datasets have good performance for areal ET in the study area. The DHSVM model calibrated based on Scheme I produces acceptable performance in runoff simulation (Kling–Gupta Efficiency, KGE = 0.87), but not for ET simulation (KGE < 0.7). However, reasonable simulations can be achieved for both variables based on Scheme II. The KGE value of runoff simulation can reach 0.87(0.91), 0.72(0.85), and 0.75(0.86) in the calibration (validation) period based on Scheme II (PML), Scheme II (FLUXCOM), and Scheme II (GLEAM), respectively. Simultaneously, ET simulations are greatly improved both in the calibration and validation periods. Furthermore, incorporating ET data into all three Scheme II variants is able to improve the performance of extreme flow simulations (including extreme low flow and high flow). Based on the improvement of the three datasets in extreme flow simulations, PML can be utilized for multi-variable calibration in drought forecasting, and FLUXCOM and GLEAM are good choices for flood forecasting.