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1. Seliciclib (R-roscovitine) induces apoptosis in undifferentiated nasopharyngeal cancer (NPC) in vivo and in vitro

Author

Manuel Salto-Tellez, Y.-F. Lai, Simon Green, T. Loh, Ross A. Soo, Wen Son Hsieh, B.-K. Peh, C.-Y. Cui, Boon Cher Goh, and B. Mow

Subjects
Cancer Research, Cell cycle checkpoint, Biology, In vitro, law.invention, chemistry.chemical_compound, Oncology, chemistry, Apoptosis, law, Cyclin-dependent kinase, In vivo, Cancer research, biology.protein, Suppressor, Seliciclib, Nasopharyngeal cancer
Abstract

3145 Cyclin dependent kinase (CDK) inhibition mimics tumor suppressor protein function and induces cell cycle arrest and apoptosis in cancer cell lines. Seliciclib, an orally administered inhibitor...

Published
2005

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